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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDE4A-CHGA (FusionGDB2 ID:63692)

Fusion Gene Summary for PDE4A-CHGA

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4A-CHGA
Fusion gene ID: 63692
HgeneTgene
Gene symbol

PDE4A

CHGA

Gene ID

5141

1113

Gene namephosphodiesterase 4Achromogranin A
SynonymsDPDE2|PDE4|PDE46CGA
Cytomap

19p13.2

14q32.12

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4Aphosphodiesterase 4A, cAMP-specific (duncephosphodiesterase E2 dunce homolog, Drosophilaphosphodiesterase isozyme 4chromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein I
Modification date2020031320200315
UniProtAcc.

P10645

Ensembl transtripts involved in fusion geneENST00000293683, ENST00000344979, 
ENST00000352831, ENST00000380702, 
ENST00000440014, ENST00000592685, 
ENST00000553866, ENST00000216492, 
ENST00000334654, 
Fusion gene scores* DoF score7 X 6 X 5=21014 X 26 X 3=1092
# samples 819
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1092*10)=-2.5229015325889
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE4A [Title/Abstract] AND CHGA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHGA(93399084)-PDE4A(10577651), # samples:1
PDE4A(10577669)-CHGA(93398897), # samples:1
Anticipated loss of major functional domain due to fusion event.PDE4A-CHGA seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PDE4A-CHGA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PDE4A-CHGA seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CHGA-PDE4A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CHGA-PDE4A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CHGA-PDE4A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHGA

GO:0002551

mast cell chemotaxis

21214543

TgeneCHGA

GO:0032762

mast cell cytokine production

21214543

TgeneCHGA

GO:0033604

negative regulation of catecholamine secretion

15326220

TgeneCHGA

GO:0043303

mast cell degranulation

21214543

TgeneCHGA

GO:0045576

mast cell activation

21214543

TgeneCHGA

GO:0050829

defense response to Gram-negative bacterium

15723172

TgeneCHGA

GO:0050830

defense response to Gram-positive bacterium

15723172


check buttonFusion gene breakpoints across PDE4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHGA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A3J0-01APDE4Achr19

10577669

+CHGAchr14

93398897

+


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Fusion Gene ORF analysis for PDE4A-CHGA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000293683ENST00000553866PDE4Achr19

10577669

+CHGAchr14

93398897

+
5CDS-intronENST00000344979ENST00000553866PDE4Achr19

10577669

+CHGAchr14

93398897

+
5CDS-intronENST00000352831ENST00000553866PDE4Achr19

10577669

+CHGAchr14

93398897

+
5CDS-intronENST00000380702ENST00000553866PDE4Achr19

10577669

+CHGAchr14

93398897

+
5CDS-intronENST00000440014ENST00000553866PDE4Achr19

10577669

+CHGAchr14

93398897

+
5CDS-intronENST00000592685ENST00000553866PDE4Achr19

10577669

+CHGAchr14

93398897

+
Frame-shiftENST00000293683ENST00000216492PDE4Achr19

10577669

+CHGAchr14

93398897

+
Frame-shiftENST00000293683ENST00000334654PDE4Achr19

10577669

+CHGAchr14

93398897

+
Frame-shiftENST00000352831ENST00000216492PDE4Achr19

10577669

+CHGAchr14

93398897

+
Frame-shiftENST00000352831ENST00000334654PDE4Achr19

10577669

+CHGAchr14

93398897

+
Frame-shiftENST00000440014ENST00000216492PDE4Achr19

10577669

+CHGAchr14

93398897

+
Frame-shiftENST00000440014ENST00000334654PDE4Achr19

10577669

+CHGAchr14

93398897

+
In-frameENST00000344979ENST00000216492PDE4Achr19

10577669

+CHGAchr14

93398897

+
In-frameENST00000344979ENST00000334654PDE4Achr19

10577669

+CHGAchr14

93398897

+
In-frameENST00000380702ENST00000216492PDE4Achr19

10577669

+CHGAchr14

93398897

+
In-frameENST00000380702ENST00000334654PDE4Achr19

10577669

+CHGAchr14

93398897

+
In-frameENST00000592685ENST00000216492PDE4Achr19

10577669

+CHGAchr14

93398897

+
In-frameENST00000592685ENST00000334654PDE4Achr19

10577669

+CHGAchr14

93398897

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000592685PDE4Achr1910577669+ENST00000216492CHGAchr1493398897+33922600842024646
ENST00000592685PDE4Achr1910577669+ENST00000334654CHGAchr1493398897+33522600842024646
ENST00000380702PDE4Achr1910577669+ENST00000216492CHGAchr1493398897+5288449601940646
ENST00000380702PDE4Achr1910577669+ENST00000334654CHGAchr1493398897+5248449601940646
ENST00000344979PDE4Achr1910577669+ENST00000216492CHGAchr1493398897+326424723251614429
ENST00000344979PDE4Achr1910577669+ENST00000334654CHGAchr1493398897+322424723251614429

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000592685ENST00000216492PDE4Achr1910577669+CHGAchr1493398897+0.0347542130.9652457
ENST00000592685ENST00000334654PDE4Achr1910577669+CHGAchr1493398897+0.034718310.9652817
ENST00000380702ENST00000216492PDE4Achr1910577669+CHGAchr1493398897+0.0096022570.9903977
ENST00000380702ENST00000334654PDE4Achr1910577669+CHGAchr1493398897+0.0100903190.98990965
ENST00000344979ENST00000216492PDE4Achr1910577669+CHGAchr1493398897+0.0069702150.9930298
ENST00000344979ENST00000334654PDE4Achr1910577669+CHGAchr1493398897+0.0072524640.9927475

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Fusion Genomic Features for PDE4A-CHGA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDE4A-CHGA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:93399084/chr14:10577651)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHGA

P10645

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHGAchr19:10577669chr14:93398897ENST0000021649208181_1910458.0RegionNote=O-glycosylated at one site only in cerebrospinal fluid
TgeneCHGAchr19:10577669chr14:93398897ENST000002164920841_590458.0RegionNote=O-glycosylated at one site only in cerebrospinal fluid

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Achr19:10577669chr14:93398897ENST00000293683+115357_6860861.0DomainPDEase
HgenePDE4Achr19:10577669chr14:93398897ENST00000344979+110357_6860648.0DomainPDEase
HgenePDE4Achr19:10577669chr14:93398897ENST00000352831+115357_6860887.0DomainPDEase
HgenePDE4Achr19:10577669chr14:93398897ENST00000380702+116357_6860865.0DomainPDEase
HgenePDE4Achr19:10577669chr14:93398897ENST00000440014+115357_6860826.0DomainPDEase
HgenePDE4Achr19:10577669chr14:93398897ENST00000592685+117357_6860865.0DomainPDEase
HgenePDE4Achr19:10577669chr14:93398897ENST00000293683+115433_4370861.0Nucleotide bindingcAMP
HgenePDE4Achr19:10577669chr14:93398897ENST00000344979+110433_4370648.0Nucleotide bindingcAMP
HgenePDE4Achr19:10577669chr14:93398897ENST00000352831+115433_4370887.0Nucleotide bindingcAMP
HgenePDE4Achr19:10577669chr14:93398897ENST00000380702+116433_4370865.0Nucleotide bindingcAMP
HgenePDE4Achr19:10577669chr14:93398897ENST00000440014+115433_4370826.0Nucleotide bindingcAMP
HgenePDE4Achr19:10577669chr14:93398897ENST00000592685+117433_4370865.0Nucleotide bindingcAMP


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Fusion Gene Sequence for PDE4A-CHGA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63692_63692_1_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000344979_CHGA_chr14_93398897_ENST00000216492_length(transcript)=3264nt_BP=2472nt
CGGGTGCACACACAGAGCTCCGCAGCCTCCTCCTGGGACCCTTGCCCTGCCCCCCTCCCATGGGCACGGACCCCCCACCGCCTCCACCCA
CTGCCGCGGGGGGGCCCGTTGGGGCCCAGGGCTGGCGGGCCATGTAACCAGGGCTGCTGCTGGGAGCGCGGAGGGGAAGGGAGCCCCCAG
CCCTGCTGGGCCGGCCCAGGCCCCTCCGCGGCTCCCCCTTCCACTACCCACCTGCCCGGCACCCCCTCCCCAGTGGTTGTTAACCCCGGG
ACTCCCCAAGCCCAGCCTCTGTGTGCAGCAGCCCCAGGCGGGCTAAGTCTCCAAGATGCCCTTGGTGGATTTCTTCTGCGAGACCTGCTC
TAAGCCTTGGCTGGTGGGCTGGTGGGACCAGTTCAAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGAAA
CCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAACAGAATGAAGTGGAGATCCCATCACCCACGATGAAGGAACGAGAAAAACA
GCAAGCGCCGCGACCAAGACCCTCCCAGCCGCCCCCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAGTT
GATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGATTTGGGGTGAAGACCGATCAAGAAGAGCTCCTGGCCCAAGAACTGGAGAA
CCTGAACAAGTGGGGCCTGAACATCTTTTGCGTGTCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAGGA
GCGGGACCTGCTGAAGAAATTCCGCATCCCTGTGGACACGATGGTGACATACATGCTGACGCTGGAGGATCACTACCACGCTGACGTGGC
CTACCATAACAGCCTGCACGCAGCTGACGTGCTGCAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGACCT
GGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGATGTGGATCACCCTGGGGTCTCCAACCAGTTCCTCATCAACACCAATTCGGA
GCTGGCGCTCATGTACAACGATGAGTCGGTGCTCGAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGACAT
CTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGCAAGATGGTCATCGACATGGTGCTGGCCACGGACATGTCCAAGCACATGAC
CCTCCTGGCTGACCTGAAGACCATGGTGGAGACCAAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATCCA
GGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAGCTGTACCGCCAGTGGACAGACCGCATCATGGC
CGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAGTC
TCAGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGT
TCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGC
AGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGG
AAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCT
CGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCC
TGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGA
GGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCT
GATCCCCAGACCTCTGTCCCTGTTCCCCTCCACTCCTCCCCTCACTCCCCTGCTCCCCCGACCACCTCCTCCTCTGCCTCAAAGACTCTT
GTCCTCTTGTCCCTCCTGAGAAAAAAGAAAACGAAAAGTGGGGTTTTTTTCTGTTTTCTTTTTTTCCCCTTTCCCCCTGCCCCCACCCAC
GGGGCCTTTTTTTGGAGGTGGGGGCTGGGGAATGAGGGGCTGAGGTCCCGGAAGGGATTTTATTTTTTTGAATTTTAATTGTAACATTTT
TAGAAAAAGAACAAAAAAAGAAAAAAAAAAGAAAGAAACACAGGCTCTCCAAGGAGTGGGAGGACTCCAAACGCTGGAGCAAGATGGACC
AGCTGGCCAAGGAGCTGACGGCTGAGAAGCGGCTGGAGGGGCAGGAGGAGGAGGAGGACAACCGGGACAGTTCCATGAAGCTCTCCTTCC
GGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACGAGGCTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCC
TGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGCAGCGCAAACCGCAGACCAGAGGACCAGGAGCTGGAGAGCC
TGTCGGCCATTGAAGCAGAGCTGGAGAAAGTGGCCCACCAGCTGCAGGCACTACGGCGGGGCTGAGACACCGGCTGGCAGGGCTGGCCCC
AGGGCACCCTGTGGCCCTGGCTCTGCTGTCCCCTTGGCAGGTCCTGGCCAGATGGCCCGGATGCTGCTTCCGGTAGGGAGGCAGCCTCCA
GCCTGCCCAAGCCCAGGCCACCCTATCGCCCCCTACGCGCCTTGTCTCCTACTCCTGACTCCTACCTGCCCTGGAACATCCTTTGCAGGG
CAGCCCCACAACTTTAAACATTGACGATTCCTTCTCTGAACACAGGCAGCTTTCTAGAAGTTTCCCTTCCTCCATCCTATCCACTGGGCA
CAACTGCAATAACTTCTGACCTTTTGGTGAAAGCTGAGAACTCCTGACTGTAACATATTCTGTATGAACTTTATCTAAAGAAAAATAAAT

>63692_63692_1_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000344979_CHGA_chr14_93398897_ENST00000216492_length(amino acids)=429AA_BP=
MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHL
QPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
GFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL

--------------------------------------------------------------
>63692_63692_2_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000344979_CHGA_chr14_93398897_ENST00000334654_length(transcript)=3224nt_BP=2472nt
CGGGTGCACACACAGAGCTCCGCAGCCTCCTCCTGGGACCCTTGCCCTGCCCCCCTCCCATGGGCACGGACCCCCCACCGCCTCCACCCA
CTGCCGCGGGGGGGCCCGTTGGGGCCCAGGGCTGGCGGGCCATGTAACCAGGGCTGCTGCTGGGAGCGCGGAGGGGAAGGGAGCCCCCAG
CCCTGCTGGGCCGGCCCAGGCCCCTCCGCGGCTCCCCCTTCCACTACCCACCTGCCCGGCACCCCCTCCCCAGTGGTTGTTAACCCCGGG
ACTCCCCAAGCCCAGCCTCTGTGTGCAGCAGCCCCAGGCGGGCTAAGTCTCCAAGATGCCCTTGGTGGATTTCTTCTGCGAGACCTGCTC
TAAGCCTTGGCTGGTGGGCTGGTGGGACCAGTTCAAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGAAA
CCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAACAGAATGAAGTGGAGATCCCATCACCCACGATGAAGGAACGAGAAAAACA
GCAAGCGCCGCGACCAAGACCCTCCCAGCCGCCCCCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAGTT
GATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGATTTGGGGTGAAGACCGATCAAGAAGAGCTCCTGGCCCAAGAACTGGAGAA
CCTGAACAAGTGGGGCCTGAACATCTTTTGCGTGTCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAGGA
GCGGGACCTGCTGAAGAAATTCCGCATCCCTGTGGACACGATGGTGACATACATGCTGACGCTGGAGGATCACTACCACGCTGACGTGGC
CTACCATAACAGCCTGCACGCAGCTGACGTGCTGCAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGACCT
GGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGATGTGGATCACCCTGGGGTCTCCAACCAGTTCCTCATCAACACCAATTCGGA
GCTGGCGCTCATGTACAACGATGAGTCGGTGCTCGAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGACAT
CTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGCAAGATGGTCATCGACATGGTGCTGGCCACGGACATGTCCAAGCACATGAC
CCTCCTGGCTGACCTGAAGACCATGGTGGAGACCAAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATCCA
GGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAGCTGTACCGCCAGTGGACAGACCGCATCATGGC
CGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAGTC
TCAGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGT
TCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGC
AGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGG
AAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCT
CGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCC
TGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGA
GGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCT
GATCCCCAGACCTCTGTCCCTGTTCCCCTCCACTCCTCCCCTCACTCCCCTGCTCCCCCGACCACCTCCTCCTCTGCCTCAAAGACTCTT
GTCCTCTTGTCCCTCCTGAGAAAAAAGAAAACGAAAAGTGGGGTTTTTTTCTGTTTTCTTTTTTTCCCCTTTCCCCCTGCCCCCACCCAC
GGGGCCTTTTTTTGGAGGTGGGGGCTGGGGAATGAGGGGCTGAGGTCCCGGAAGGGATTTTATTTTTTTGAATTTTAATTGTAACATTTT
TAGAAAAAGAACAAAAAAAGAAAAAAAAAAGAAAGAAACACAGGCTCTCCAAGGAGTGGGAGGACTCCAAACGCTGGAGCAAGATGGACC
AGCTGGCCAAGGAGCTGACGGCTGAGAAGCGGCTGGAGGGGCAGGAGGAGGAGGAGGACAACCGGGACAGTTCCATGAAGCTCTCCTTCC
GGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACGAGGCTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCC
TGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGCAGCGCAAACCGCAGACCAGAGGACCAGGAGCTGGAGAGCC
TGTCGGCCATTGAAGCAGAGCTGGAGAAAGTGGCCCACCAGCTGCAGGCACTACGGCGGGGCTGAGACACCGGCTGGCAGGGCTGGCCCC
AGGGCACCCTGTGGCCCTGGCTCTGCTGTCCCCTTGGCAGGTCCTGGCCAGATGGCCCGGATGCTGCTTCCGGTAGGGAGGCAGCCTCCA
GCCTGCCCAAGCCCAGGCCACCCTATCGCCCCCTACGCGCCTTGTCTCCTACTCCTGACTCCTACCTGCCCTGGAACATCCTTTGCAGGG
CAGCCCCACAACTTTAAACATTGACGATTCCTTCTCTGAACACAGGCAGCTTTCTAGAAGTTTCCCTTCCTCCATCCTATCCACTGGGCA

>63692_63692_2_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000344979_CHGA_chr14_93398897_ENST00000334654_length(amino acids)=429AA_BP=
MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHL
QPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
GFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL

--------------------------------------------------------------
>63692_63692_3_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000380702_CHGA_chr14_93398897_ENST00000216492_length(transcript)=5288nt_BP=4496nt
ATGAAGAGGAGTCGCAGTGCCCTGTCCGTGGCAGGGACCGGGGACGAGAGGTCGAGGGAGACCCCCGAATCCGACCGTGCCAACATGCTG
GGGGCCGACCTGCGTCGCCCTCGCCGCCGCCTCTCGTCCGGTCCTGGCCTGGGCTGGGCCCAGCCTGAGCCCTCGGACCCTGGGGTCCCT
CTGCCGCCACGGCCCACCACCCTGCCGCTGCTGATCCCACCGCGGATTTCCATCACCAGGGCCGAGAACGACAGCTTCGAGGCAGAGAAT
GGGCCGACACCATCTCCTGGCCGCAGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGCCAGCGC
CGGGAGTCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACCATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCAC
GCTGAAGACCTCATCGTAACACCATTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAATGTGCCC
GTTCCCAGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCCACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGG
GAGACTCTGGAGGAGCTGGACTGGTGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCACAAGTTC
AAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGAAACCAGGTCTCAGAGTACATTTCCACAACATTCCTG
GACAAACAGAATGAAGTGGAGATCCCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAGCCGCCC
CCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAGTTGATGCATAGTAACAGCCTGAACAACTCTAACATT
CCCCGATTTGGGGTGAAGACCGATCAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTTTGCGTG
TCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAGGAGCGGGACCTGCTGAAGAAATTCCGCATCCCTGTG
GACACGATGGTGACATACATGCTGACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGACGTGCTG
CAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGACCTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATC
CACGATGTGGATCACCCTGGGGTCTCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCGGTGCTC
GAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGACATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGC
CTACGCAAGATGGTCATCGACATGGTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTGGAGACC
AAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATCCAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTC
AGCAACCCCACCAAGCCGCTGGAGCTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAG
CGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTACTACAGCGCCATCCGGCAGAGCCCATC
TCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGA
GGAAGAAATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGC
AACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTA
TTTGACACAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCA
CAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGG
CCTCCCCTCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGA
GGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGATCCCCAGACCTCTGTCCCTGTTCCCCTCCACT
CCTCCCCTCACTCCCCTGCTCCCCCGACCACCTCCTCCTCTGCCTCAAAGACTCTTGTCCTCTTGTCCCTCCTGAGAAAAAAGAAAACGA
AAAGTGGGGTTTTTTTCTGTTTTCTTTTTTTCCCCTTTCCCCCTGCCCCCACCCACGGGGCCTTTTTTTGGAGGTGGGGGCTGGGGAATG
AGGGGCTGAGGTCCCGGAAGGGATTTTATTTTTTTGAATTTTAATTGTAACATTTTTAGAAAAAGAACAAAAAAAGAAAAAAAAAAGAAA
GAAACACAGCAACTGTAGATGCTCCTGTTCCTGGTTCCCGCTTTCCACTTCCAAATCCCTCCCCTCACCTTCCCCCACTGCCCCCCAAGT
TCCAGGCTCAGTCTTCCAGCCGCCTGGGGAGTCTCTACCTGGGCCCAAGCAGGTGTGGGGCCTCCTTCTGGGCTTTTCTTCTGAATTTAG
AGGATTTCTAGAACGTGGTCAGGAATAGCCATTCTAGGCGGGGCTGGGGCCAGGGTGGGGGGCAGTCACTGTGGGAGGTCCCAGCTCCAG
CCCCCCTCTGGTTTGCTGCCTCCTCTCCCCTCTAAAAAAGTCTTCCGCTTGATTTTGCACAATCCCGGCGATACTCCTGGCGATACTGAC
TAGAAAGTCAGGGAGCTGGGGGAGCTGTTCACTTTAGGATACGGGGGTGGTATGGAAGGGAGCGTTCACACCGCCAGCCTCGGGCCTGGG
ATTTGAGGAGGGCCCTAGACCTCCTCCACTCTCCATCCCCTTTCCCTTCCACTTTGGGTTCACTTTGAATTTTCTCCGTTTTTTGGGGCA
GTGGCTCTGATCCACTCACCCCCCCGCCCCCCGCCCCACTTCTAGCTGCTTCTCCTCTTGTTTCTGCCTTAATAATTCCCACGGCCACAG
GCAAGGGGGTTGCAGTGGCCGCCTGCACCTTGGATGAGGCAGGGCCAGGCGCCCAGAACCCCCATCCTGGCCGCACCCCCCTTTCCAGGG
TCCTCCGGACCCCACCTTCCACACTCTGATCACAGCCCCCCTACCTTTTGCCCTAGGAGGAAGCAATAATGGTGTATACCCTCATTCTCA
TTCCTGGGCAGCCCTTCCTTCCACCCTGGCACCAAAATAATTTCTCCTCCATCCGTACCTTGCCTAGCCTCTCCCTCTCCCCCAGCTAGT
CCCTGAGCAATACGGCAGACAGATGCAAGACCATTTTTCTCCAAGCCATGGGGGACTGTTTGGAAGGAAAGCCCCCTCTCTCCCTCCTCC
CCTCGCCCTCGGCCTGGTTCTGCAGCTGGACCGACCTCATTCATCGCCTGCCCCCTACCCAATTCTGAGCACACGGTACTGTAGCCCCCA
GTTCCTCCCTAGCCTTCCATCCCTCTGTCCACCCCAGGGGGAGGTAACCCCGCACTCACACTCCCTTGATGCTGTCTGTACAGGGTTCAT
ATTTTGTAGCGAAAGTCGTTTTTGTCCCAGCCGGCGATCGGAGTGGGCCTTTTCTTTCTTTTTGTTCATTCTTTACCTTTTTTTCTTTTC
TTTCTTTCTTTTTTGTACATACTGTAAGGTTGGTTTGTAAATTATTCTACGGAGGCAAAAAGGGAAAATAAAAACTTGCCCTTCCCTGGC
TGACCCAGTCGGGAAGGTAGGGAAGGAGGTCTCCCGTTGGGAGAGTCTCTGTTCCTGCTGTATTATACAAACTGTACCATAGTCCTGGGA
AAAGGGTGGACTCACCGCTGTTGTTTTATGGGAAGTCGTGTCATCCTAGGGGTTGGGGCTGGGCAGAGCCTGTCCCCTCCCCCCTTCTCC
AGGAGCCAGGGGGTGACTGGAGAGACAGACCCACCCCCAAGCAGGGCTCCTCTCCCCAGGGTGAGCACAGGACCTCTGTAAGCTGCTTGT
GTATTGTCCACTTTGACGATCAGTCATTCGGTCCGTTGATCAATAATCCTTCGATCTTGTCTCCAATTAAACCGAGGCTTTCACCGGGCT
CTCCAAGGAGTGGGAGGACTCCAAACGCTGGAGCAAGATGGACCAGCTGGCCAAGGAGCTGACGGCTGAGAAGCGGCTGGAGGGGCAGGA
GGAGGAGGAGGACAACCGGGACAGTTCCATGAAGCTCTCCTTCCGGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACG
AGGCTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGA
GGGCAGCGCAAACCGCAGACCAGAGGACCAGGAGCTGGAGAGCCTGTCGGCCATTGAAGCAGAGCTGGAGAAAGTGGCCCACCAGCTGCA
GGCACTACGGCGGGGCTGAGACACCGGCTGGCAGGGCTGGCCCCAGGGCACCCTGTGGCCCTGGCTCTGCTGTCCCCTTGGCAGGTCCTG
GCCAGATGGCCCGGATGCTGCTTCCGGTAGGGAGGCAGCCTCCAGCCTGCCCAAGCCCAGGCCACCCTATCGCCCCCTACGCGCCTTGTC
TCCTACTCCTGACTCCTACCTGCCCTGGAACATCCTTTGCAGGGCAGCCCCACAACTTTAAACATTGACGATTCCTTCTCTGAACACAGG
CAGCTTTCTAGAAGTTTCCCTTCCTCCATCCTATCCACTGGGCACAACTGCAATAACTTCTGACCTTTTGGTGAAAGCTGAGAACTCCTG

>63692_63692_3_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000380702_CHGA_chr14_93398897_ENST00000216492_length(amino acids)=646AA_BP=
MKRSRSALSVAGTGDERSRETPESDRANMLGADLRRPRRRLSSGPGLGWAQPEPSDPGVPLPPRPTTLPLLIPPRISITRAENDSFEAEN
GPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP
VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFL
DKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCV
SDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAI
HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVET
KKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVLQRHPAEPI

--------------------------------------------------------------
>63692_63692_4_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000380702_CHGA_chr14_93398897_ENST00000334654_length(transcript)=5248nt_BP=4496nt
ATGAAGAGGAGTCGCAGTGCCCTGTCCGTGGCAGGGACCGGGGACGAGAGGTCGAGGGAGACCCCCGAATCCGACCGTGCCAACATGCTG
GGGGCCGACCTGCGTCGCCCTCGCCGCCGCCTCTCGTCCGGTCCTGGCCTGGGCTGGGCCCAGCCTGAGCCCTCGGACCCTGGGGTCCCT
CTGCCGCCACGGCCCACCACCCTGCCGCTGCTGATCCCACCGCGGATTTCCATCACCAGGGCCGAGAACGACAGCTTCGAGGCAGAGAAT
GGGCCGACACCATCTCCTGGCCGCAGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGCCAGCGC
CGGGAGTCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACCATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCAC
GCTGAAGACCTCATCGTAACACCATTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAATGTGCCC
GTTCCCAGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCCACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGG
GAGACTCTGGAGGAGCTGGACTGGTGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCACAAGTTC
AAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGAAACCAGGTCTCAGAGTACATTTCCACAACATTCCTG
GACAAACAGAATGAAGTGGAGATCCCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAGCCGCCC
CCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAGTTGATGCATAGTAACAGCCTGAACAACTCTAACATT
CCCCGATTTGGGGTGAAGACCGATCAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTTTGCGTG
TCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAGGAGCGGGACCTGCTGAAGAAATTCCGCATCCCTGTG
GACACGATGGTGACATACATGCTGACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGACGTGCTG
CAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGACCTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATC
CACGATGTGGATCACCCTGGGGTCTCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCGGTGCTC
GAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGACATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGC
CTACGCAAGATGGTCATCGACATGGTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTGGAGACC
AAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATCCAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTC
AGCAACCCCACCAAGCCGCTGGAGCTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAG
CGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTACTACAGCGCCATCCGGCAGAGCCCATC
TCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGA
GGAAGAAATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGC
AACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTA
TTTGACACAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCA
CAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGG
CCTCCCCTCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGA
GGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGATCCCCAGACCTCTGTCCCTGTTCCCCTCCACT
CCTCCCCTCACTCCCCTGCTCCCCCGACCACCTCCTCCTCTGCCTCAAAGACTCTTGTCCTCTTGTCCCTCCTGAGAAAAAAGAAAACGA
AAAGTGGGGTTTTTTTCTGTTTTCTTTTTTTCCCCTTTCCCCCTGCCCCCACCCACGGGGCCTTTTTTTGGAGGTGGGGGCTGGGGAATG
AGGGGCTGAGGTCCCGGAAGGGATTTTATTTTTTTGAATTTTAATTGTAACATTTTTAGAAAAAGAACAAAAAAAGAAAAAAAAAAGAAA
GAAACACAGCAACTGTAGATGCTCCTGTTCCTGGTTCCCGCTTTCCACTTCCAAATCCCTCCCCTCACCTTCCCCCACTGCCCCCCAAGT
TCCAGGCTCAGTCTTCCAGCCGCCTGGGGAGTCTCTACCTGGGCCCAAGCAGGTGTGGGGCCTCCTTCTGGGCTTTTCTTCTGAATTTAG
AGGATTTCTAGAACGTGGTCAGGAATAGCCATTCTAGGCGGGGCTGGGGCCAGGGTGGGGGGCAGTCACTGTGGGAGGTCCCAGCTCCAG
CCCCCCTCTGGTTTGCTGCCTCCTCTCCCCTCTAAAAAAGTCTTCCGCTTGATTTTGCACAATCCCGGCGATACTCCTGGCGATACTGAC
TAGAAAGTCAGGGAGCTGGGGGAGCTGTTCACTTTAGGATACGGGGGTGGTATGGAAGGGAGCGTTCACACCGCCAGCCTCGGGCCTGGG
ATTTGAGGAGGGCCCTAGACCTCCTCCACTCTCCATCCCCTTTCCCTTCCACTTTGGGTTCACTTTGAATTTTCTCCGTTTTTTGGGGCA
GTGGCTCTGATCCACTCACCCCCCCGCCCCCCGCCCCACTTCTAGCTGCTTCTCCTCTTGTTTCTGCCTTAATAATTCCCACGGCCACAG
GCAAGGGGGTTGCAGTGGCCGCCTGCACCTTGGATGAGGCAGGGCCAGGCGCCCAGAACCCCCATCCTGGCCGCACCCCCCTTTCCAGGG
TCCTCCGGACCCCACCTTCCACACTCTGATCACAGCCCCCCTACCTTTTGCCCTAGGAGGAAGCAATAATGGTGTATACCCTCATTCTCA
TTCCTGGGCAGCCCTTCCTTCCACCCTGGCACCAAAATAATTTCTCCTCCATCCGTACCTTGCCTAGCCTCTCCCTCTCCCCCAGCTAGT
CCCTGAGCAATACGGCAGACAGATGCAAGACCATTTTTCTCCAAGCCATGGGGGACTGTTTGGAAGGAAAGCCCCCTCTCTCCCTCCTCC
CCTCGCCCTCGGCCTGGTTCTGCAGCTGGACCGACCTCATTCATCGCCTGCCCCCTACCCAATTCTGAGCACACGGTACTGTAGCCCCCA
GTTCCTCCCTAGCCTTCCATCCCTCTGTCCACCCCAGGGGGAGGTAACCCCGCACTCACACTCCCTTGATGCTGTCTGTACAGGGTTCAT
ATTTTGTAGCGAAAGTCGTTTTTGTCCCAGCCGGCGATCGGAGTGGGCCTTTTCTTTCTTTTTGTTCATTCTTTACCTTTTTTTCTTTTC
TTTCTTTCTTTTTTGTACATACTGTAAGGTTGGTTTGTAAATTATTCTACGGAGGCAAAAAGGGAAAATAAAAACTTGCCCTTCCCTGGC
TGACCCAGTCGGGAAGGTAGGGAAGGAGGTCTCCCGTTGGGAGAGTCTCTGTTCCTGCTGTATTATACAAACTGTACCATAGTCCTGGGA
AAAGGGTGGACTCACCGCTGTTGTTTTATGGGAAGTCGTGTCATCCTAGGGGTTGGGGCTGGGCAGAGCCTGTCCCCTCCCCCCTTCTCC
AGGAGCCAGGGGGTGACTGGAGAGACAGACCCACCCCCAAGCAGGGCTCCTCTCCCCAGGGTGAGCACAGGACCTCTGTAAGCTGCTTGT
GTATTGTCCACTTTGACGATCAGTCATTCGGTCCGTTGATCAATAATCCTTCGATCTTGTCTCCAATTAAACCGAGGCTTTCACCGGGCT
CTCCAAGGAGTGGGAGGACTCCAAACGCTGGAGCAAGATGGACCAGCTGGCCAAGGAGCTGACGGCTGAGAAGCGGCTGGAGGGGCAGGA
GGAGGAGGAGGACAACCGGGACAGTTCCATGAAGCTCTCCTTCCGGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACG
AGGCTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGA
GGGCAGCGCAAACCGCAGACCAGAGGACCAGGAGCTGGAGAGCCTGTCGGCCATTGAAGCAGAGCTGGAGAAAGTGGCCCACCAGCTGCA
GGCACTACGGCGGGGCTGAGACACCGGCTGGCAGGGCTGGCCCCAGGGCACCCTGTGGCCCTGGCTCTGCTGTCCCCTTGGCAGGTCCTG
GCCAGATGGCCCGGATGCTGCTTCCGGTAGGGAGGCAGCCTCCAGCCTGCCCAAGCCCAGGCCACCCTATCGCCCCCTACGCGCCTTGTC
TCCTACTCCTGACTCCTACCTGCCCTGGAACATCCTTTGCAGGGCAGCCCCACAACTTTAAACATTGACGATTCCTTCTCTGAACACAGG
CAGCTTTCTAGAAGTTTCCCTTCCTCCATCCTATCCACTGGGCACAACTGCAATAACTTCTGACCTTTTGGTGAAAGCTGAGAACTCCTG

>63692_63692_4_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000380702_CHGA_chr14_93398897_ENST00000334654_length(amino acids)=646AA_BP=
MKRSRSALSVAGTGDERSRETPESDRANMLGADLRRPRRRLSSGPGLGWAQPEPSDPGVPLPPRPTTLPLLIPPRISITRAENDSFEAEN
GPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP
VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFL
DKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCV
SDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAI
HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVET
KKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVLQRHPAEPI

--------------------------------------------------------------
>63692_63692_5_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000592685_CHGA_chr14_93398897_ENST00000216492_length(transcript)=3392nt_BP=2600nt
CGTCACGCCCCAGGAGAGGCAATAGGAGGCCCTGGCCCTGCCGACATGGCCACCGCAGTCCCAACGGCGCGCTAGGTTGGCGAGATGAAG
AGGAGTCGCAGTGCCCTGTCCGTGGCAGGGACCGGGGACGAGAGGTCGAGGGAGACCCCCGAATCCGACCGTGCCAACATGCTGGGGGCC
GACCTGCGTCGCCCTCGCCGCCGCCTCTCGTCCGGTCCTGGCCTGGGCTGGGCCCAGCCTGAGCCCTCGGACCCTGGGGTCCCTCTGCCG
CCACGGCCCACCACCCTGCCGCTGCTGATCCCACCGCGGATTTCCATCACCAGGGCCGAGAACGACAGCTTCGAGGCAGAGAATGGGCCG
ACACCATCTCCTGGCCGCAGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGCCAGCGCCGGGAG
TCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACCATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCACGCTGAA
GACCTCATCGTAACACCATTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAATGTGCCCGTTCCC
AGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCCACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGGGAGACT
CTGGAGGAGCTGGACTGGTGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCACAAGTTCAAAAGG
ATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGAAACCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAA
CAGAATGAAGTGGAGATCCCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAGCCGCCCCCGCCC
CCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAGTTGATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGA
TTTGGGGTGAAGACCGATCAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTTTGCGTGTCGGAT
TACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAGGAGCGGGACCTGCTGAAGAAATTCCGCATCCCTGTGGACACG
ATGGTGACATACATGCTGACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGACGTGCTGCAGTCC
ACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGACCTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGAT
GTGGATCACCCTGGGGTCTCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCGGTGCTCGAGAAT
CACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGACATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGC
AAGATGGTCATCGACATGGTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTGGAGACCAAGAAA
GTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATCCAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAAC
CCCACCAAGCCGCTGGAGCTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGC
ATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCC
ACCCGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGA
AATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCAT
AGCCTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGAC
ACAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAG
CCCCTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCC
CTCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACAC
ATCCGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGATCCCCAGACCTCTGTCCCTGTTCCCCTCGGCTCTCCAA
GGAGTGGGAGGACTCCAAACGCTGGAGCAAGATGGACCAGCTGGCCAAGGAGCTGACGGCTGAGAAGCGGCTGGAGGGGCAGGAGGAGGA
GGAGGACAACCGGGACAGTTCCATGAAGCTCTCCTTCCGGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACGAGGCTG
GAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGCAG
CGCAAACCGCAGACCAGAGGACCAGGAGCTGGAGAGCCTGTCGGCCATTGAAGCAGAGCTGGAGAAAGTGGCCCACCAGCTGCAGGCACT
ACGGCGGGGCTGAGACACCGGCTGGCAGGGCTGGCCCCAGGGCACCCTGTGGCCCTGGCTCTGCTGTCCCCTTGGCAGGTCCTGGCCAGA
TGGCCCGGATGCTGCTTCCGGTAGGGAGGCAGCCTCCAGCCTGCCCAAGCCCAGGCCACCCTATCGCCCCCTACGCGCCTTGTCTCCTAC
TCCTGACTCCTACCTGCCCTGGAACATCCTTTGCAGGGCAGCCCCACAACTTTAAACATTGACGATTCCTTCTCTGAACACAGGCAGCTT
TCTAGAAGTTTCCCTTCCTCCATCCTATCCACTGGGCACAACTGCAATAACTTCTGACCTTTTGGTGAAAGCTGAGAACTCCTGACTGTA

>63692_63692_5_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000592685_CHGA_chr14_93398897_ENST00000216492_length(amino acids)=646AA_BP=
MKRSRSALSVAGTGDERSRETPESDRANMLGADLRRPRRRLSSGPGLGWAQPEPSDPGVPLPPRPTTLPLLIPPRISITRAENDSFEAEN
GPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP
VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFL
DKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCV
SDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAI
HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVET
KKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVLQRHPAEPI

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>63692_63692_6_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000592685_CHGA_chr14_93398897_ENST00000334654_length(transcript)=3352nt_BP=2600nt
CGTCACGCCCCAGGAGAGGCAATAGGAGGCCCTGGCCCTGCCGACATGGCCACCGCAGTCCCAACGGCGCGCTAGGTTGGCGAGATGAAG
AGGAGTCGCAGTGCCCTGTCCGTGGCAGGGACCGGGGACGAGAGGTCGAGGGAGACCCCCGAATCCGACCGTGCCAACATGCTGGGGGCC
GACCTGCGTCGCCCTCGCCGCCGCCTCTCGTCCGGTCCTGGCCTGGGCTGGGCCCAGCCTGAGCCCTCGGACCCTGGGGTCCCTCTGCCG
CCACGGCCCACCACCCTGCCGCTGCTGATCCCACCGCGGATTTCCATCACCAGGGCCGAGAACGACAGCTTCGAGGCAGAGAATGGGCCG
ACACCATCTCCTGGCCGCAGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGCCAGCGCCGGGAG
TCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACCATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCACGCTGAA
GACCTCATCGTAACACCATTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAATGTGCCCGTTCCC
AGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCCACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGGGAGACT
CTGGAGGAGCTGGACTGGTGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCACAAGTTCAAAAGG
ATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGAAACCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAA
CAGAATGAAGTGGAGATCCCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAGCCGCCCCCGCCC
CCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAGTTGATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGA
TTTGGGGTGAAGACCGATCAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTTTGCGTGTCGGAT
TACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAGGAGCGGGACCTGCTGAAGAAATTCCGCATCCCTGTGGACACG
ATGGTGACATACATGCTGACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGACGTGCTGCAGTCC
ACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGACCTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGAT
GTGGATCACCCTGGGGTCTCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCGGTGCTCGAGAAT
CACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGACATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGC
AAGATGGTCATCGACATGGTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTGGAGACCAAGAAA
GTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATCCAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAAC
CCCACCAAGCCGCTGGAGCTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGC
ATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCC
ACCCGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGA
AATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCAT
AGCCTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGAC
ACAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAG
CCCCTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCC
CTCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACAC
ATCCGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGATCCCCAGACCTCTGTCCCTGTTCCCCTCGGCTCTCCAA
GGAGTGGGAGGACTCCAAACGCTGGAGCAAGATGGACCAGCTGGCCAAGGAGCTGACGGCTGAGAAGCGGCTGGAGGGGCAGGAGGAGGA
GGAGGACAACCGGGACAGTTCCATGAAGCTCTCCTTCCGGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACGAGGCTG
GAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGCAG
CGCAAACCGCAGACCAGAGGACCAGGAGCTGGAGAGCCTGTCGGCCATTGAAGCAGAGCTGGAGAAAGTGGCCCACCAGCTGCAGGCACT
ACGGCGGGGCTGAGACACCGGCTGGCAGGGCTGGCCCCAGGGCACCCTGTGGCCCTGGCTCTGCTGTCCCCTTGGCAGGTCCTGGCCAGA
TGGCCCGGATGCTGCTTCCGGTAGGGAGGCAGCCTCCAGCCTGCCCAAGCCCAGGCCACCCTATCGCCCCCTACGCGCCTTGTCTCCTAC
TCCTGACTCCTACCTGCCCTGGAACATCCTTTGCAGGGCAGCCCCACAACTTTAAACATTGACGATTCCTTCTCTGAACACAGGCAGCTT
TCTAGAAGTTTCCCTTCCTCCATCCTATCCACTGGGCACAACTGCAATAACTTCTGACCTTTTGGTGAAAGCTGAGAACTCCTGACTGTA

>63692_63692_6_PDE4A-CHGA_PDE4A_chr19_10577669_ENST00000592685_CHGA_chr14_93398897_ENST00000334654_length(amino acids)=646AA_BP=
MKRSRSALSVAGTGDERSRETPESDRANMLGADLRRPRRRLSSGPGLGWAQPEPSDPGVPLPPRPTTLPLLIPPRISITRAENDSFEAEN
GPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP
VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFL
DKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCV
SDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAI
HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVET
KKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVLQRHPAEPI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDE4A-CHGA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDE4A-CHGA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDE4A-CHGA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource