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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDE4D-PLK2 (FusionGDB2 ID:63754)

Fusion Gene Summary for PDE4D-PLK2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4D-PLK2
Fusion gene ID: 63754
HgeneTgene
Gene symbol

PDE4D

PLK2

Gene ID

5144

10769

Gene namephosphodiesterase 4Dpolo like kinase 2
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1SNK|hPlk2|hSNK
Cytomap

5q11.2-q12.1

5q11.2

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136serine/threonine-protein kinase PLK2PLK-2serine/threonine-protein kinase SNKserum-inducible kinase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000340635, ENST00000358923, 
ENST00000360047, ENST00000405755, 
ENST00000502484, ENST00000503258, 
ENST00000507116, ENST00000546160, 
ENST00000317118, ENST00000502575, 
ENST00000503947, 		ENST00000502671, 
ENST00000274289, 
Fusion gene scores* DoF score40 X 32 X 12=153603 X 3 X 2=18
# samples 563
** MAII scorelog2(56/15360*10)=-4.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDE4D [Title/Abstract] AND PLK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDE4D(58334686)-PLK2(57754919), # samples:1
Anticipated loss of major functional domain due to fusion event.PDE4D-PLK2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLK2

GO:0006468

protein phosphorylation

20352051

TgenePLK2

GO:0007052

mitotic spindle organization

19001868

TgenePLK2

GO:0010508

positive regulation of autophagy

23983262

TgenePLK2

GO:0018105

peptidyl-serine phosphorylation

23983262

TgenePLK2

GO:0045732

positive regulation of protein catabolic process

23983262

TgenePLK2

GO:0046599

regulation of centriole replication

19001868|20352051|20531387


check buttonFusion gene breakpoints across PDE4D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-TS-A7OY-01APDE4Dchr5

58334686

-PLK2chr5

57754919

-


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Fusion Gene ORF analysis for PDE4D-PLK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340635ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
5CDS-intronENST00000358923ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
5CDS-intronENST00000360047ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
5CDS-intronENST00000405755ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
5CDS-intronENST00000502484ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
5CDS-intronENST00000503258ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
5CDS-intronENST00000507116ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
5CDS-intronENST00000546160ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
Frame-shiftENST00000358923ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
Frame-shiftENST00000502484ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
In-frameENST00000340635ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
In-frameENST00000360047ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
In-frameENST00000405755ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
In-frameENST00000503258ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
In-frameENST00000507116ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
In-frameENST00000546160ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
intron-3CDSENST00000317118ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
intron-3CDSENST00000502575ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
intron-3CDSENST00000503947ENST00000274289PDE4Dchr5

58334686

-PLK2chr5

57754919

-
intron-intronENST00000317118ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
intron-intronENST00000502575ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-
intron-intronENST00000503947ENST00000502671PDE4Dchr5

58334686

-PLK2chr5

57754919

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340635PDE4Dchr558334686-ENST00000274289PLK2chr557754919-348610971762884902
ENST00000360047PDE4Dchr558334686-ENST00000274289PLK2chr557754919-3026637312424797
ENST00000507116PDE4Dchr558334686-ENST00000274289PLK2chr557754919-325486572652881
ENST00000546160PDE4Dchr558334686-ENST00000274289PLK2chr557754919-312773802525841
ENST00000503258PDE4Dchr558334686-ENST00000274289PLK2chr557754919-363712487173035772
ENST00000405755PDE4Dchr558334686-ENST00000274289PLK2chr557754919-30736841022471789

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340635ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0045289540.9954711
ENST00000360047ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0011429680.998857
ENST00000507116ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0027431050.99725693
ENST00000546160ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0012699010.9987301
ENST00000503258ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0017381160.99826187
ENST00000405755ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0009600760.99903995

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Fusion Genomic Features for PDE4D-PLK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDE4D-PLK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:58334686/chr5:57754919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:58334686chr5:57754919ENST00000340635-61542_88307810.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000360047-61542_88171674.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000405755-61542_88185688.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502484-81742_88246749.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000503258-61542_88177680.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000507116-61542_88243746.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000546160-71642_88246749.0Compositional biasNote=Pro-rich
TgenePLK2chr5:58334686chr5:57754919ENST00000274289014510_57390686.0DomainPOLO box 1
TgenePLK2chr5:58334686chr5:57754919ENST00000274289014606_67790686.0DomainPOLO box 2
TgenePLK2chr5:58334686chr5:57754919ENST0000027428901488_9690686.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:58334686chr5:57754919ENST00000317118-11042_880519.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000358923-21142_885508.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502575-1642_880220.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000317118-110386_7150519.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000340635-615386_715307810.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000358923-211386_7155508.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000360047-615386_715171674.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000405755-615386_715185688.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502484-817386_715246749.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502575-16386_7150220.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000503258-615386_715177680.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000507116-615386_715243746.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000546160-716386_715246749.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000317118-110462_4660519.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000340635-615462_466307810.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000358923-211462_4665508.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000360047-615462_466171674.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000405755-615462_466185688.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502484-817462_466246749.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502575-16462_4660220.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000503258-615462_466177680.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000507116-615462_466243746.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000546160-716462_466246749.0Nucleotide bindingcAMP
TgenePLK2chr5:58334686chr5:57754919ENST0000027428901457_6490686.0Compositional biasNote=Poly-His
TgenePLK2chr5:58334686chr5:57754919ENST0000027428901482_33490686.0DomainProtein kinase


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Fusion Gene Sequence for PDE4D-PLK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63754_63754_1_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000340635_PLK2_chr5_57754919_ENST00000274289_length(transcript)=3486nt_BP=1097nt
GGGCCCCCTCTCGGTAGCCCTGAGGCTCTGGCGCCTTCAAGTGAGAAGCTAAGCACCAGCCTCTGCTGGGCTGCAGAAGCGGCGGCGGCG
GCAGCAGCAGCAGCAGCATCAGGAAGGCGCTCGGGCCAGCGCGGTGAACCCGGGCTGGGCAGCAGGTCGCGGAGCCGCGAGCCAGGATGG
AGGCAGAGGGCAGCAGCGCGCCGGCCCGGGCGGGCAGCGGAGAGGGCAGCGACAGCGCCGGCGGGGCCACGCTCAAAGCCCCCAAGCATC
TCTGGAGGCACGAGCAGCACCACCAGTACCCGCTCCGGCAGCCCCAGTTCCGCCTCCTGCATCCCCATCACCACCTGCCCCCGCCGCCGC
CACCCTCGCCCCAGCCCCAGCCCCAGTGTCCGCTACAGCCGCCGCCGCCGCCCCCCCTGCCGCCGCCCCCGCCGCCGCCCGGGGCTGCCC
GCGGCCGCTACGCCTCGAGCGGGGCCACCGGCCGCGTCCGGCATCGCGGCTACTCGGACACCGAGCGCTACCTGTACTGTCGCGCCATGG
ACCGCACCTCCTACGCGGTGGAGACCGGCCACCGGCCCGGCCTGAAGAAATCCAGGATGTCCTGGCCCTCCTCGTTCCAGGGACTCAGGC
GTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATT
TTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCA
TTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTG
CATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGG
CCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTG
AGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTC
ACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGT
TTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAA
AGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAG
ATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAAC
ACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGG
CCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAG
CAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTT
TGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCC
ACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACAC
ATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACA
GGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTA
TTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAG
TGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCA
CCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACA
TGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAAT
TTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATA
TTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATT
TCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTT
TCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGTA
ACTGAAAGACTTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAGATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTT
GAAGAAGATGGACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGGACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCT
TGACTTTGGACAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACCTGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGT
GCATTGATTCTTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTGGAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGG
AGGAAGCTCCCATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCGTAACTGTGAACTATGGCCATATATAATTTTTTTTCATT
AATTTTTGAAGATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTTTTTATTTATTACAGCCCAAAGAGCAGTATTTATTATCA

>63754_63754_1_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000340635_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=902AA_BP=0
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGA
ARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE
EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVV
QFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPL
EHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRP
SLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSK
HRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQW
VTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVT
DIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQR

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>63754_63754_2_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000360047_PLK2_chr5_57754919_ENST00000274289_length(transcript)=3026nt_BP=637nt
CAATACTTGTTGCAATAATTGCCCACGATAGCTGCTCAAACAAGAGAGTTGGAATTCATCTGTAAAAATCACTACATGTAACGTAGGAGA
CAAGAAAAATATTAATGACAGAAGATCTGCGAACATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGT
GGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAG
TCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGA
TATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAA
TTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAA
ACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTC
CAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGT
AGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTA
CTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGAC
AGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACT
AGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAG
AACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTG
TGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATAC
AATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACAT
CATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAG
CCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGT
GTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGA
GGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGAT
AGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGT
TCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGT
TGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCT
TCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCA
AGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACC
TCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGA
TCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGAC
AACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAACTGAAAGAC
TTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAGATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTTGAAGAAGATG
GACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGGACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCTTGACTTTGGA
CAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACCTGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGTGCATTGATTC
TTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTGGAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGGAGGAAGCTCC
CATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCGTAACTGTGAACTATGGCCATATATAATTTTTTTTCATTAATTTTTGAA
GATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTTTTTATTTATTACAGCCCAAAGAGCAGTATTTATTATCAAAATGTCTTT

>63754_63754_2_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000360047_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=797AA_BP=1
MLKQESWNSSVKITTCNVGDKKNINDRRSANMMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRS
DSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELD
WCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYIL
LEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLS
PEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGF
TPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVA
RSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGY
QLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKS

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>63754_63754_3_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000405755_PLK2_chr5_57754919_ENST00000274289_length(transcript)=3073nt_BP=684nt
ACTGCACAAAGGAAATGCCCTCACTCAGCTACAAGTGCCTCCTGCTCCGTGCGGGGCCTCAGGGCCCCAGAGCCCCGCACCAGCTCTGAC
TTCTCGTGGTTCCTGGGGATCTTGGCATCGTCCTTAAAAATGGCTTTTGTTTGGGATCCTCTGGGAGCCACGGTGCCAGGACCATCTACA
AGAGCCAAATCAAGATTGCGTTTCTCAAAGTCCTACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATG
ACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTAT
GACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTC
TTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAAC
CAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGAC
CAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTG
ACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAG
CTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGC
AGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGA
CTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGG
GACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTC
AACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACT
ACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCT
AGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGA
CTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTT
GGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTG
AAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACA
CCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGC
CTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATT
CCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGAC
CACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAA
TGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAAC
CTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTA
ATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTT
CTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGA
ATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAACTGAAAGACTTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAGA
TCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTTGAAGAAGATGGACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGGA
CTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCTTGACTTTGGACAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACCT
GTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGTGCATTGATTCTTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTGG
AACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGGAGGAAGCTCCCATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCGT
AACTGTGAACTATGGCCATATATAATTTTTTTTCATTAATTTTTGAAGATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTTT
TTATTTATTACAGCCCAAAGAGCAGTATTTATTATCAAAATGTCTTTTTTTTTATGTTGACCATTTTAAACCGTTGGCAATAAAGAGTAT

>63754_63754_3_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000405755_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=789AA_BP=1
MGILASSLKMAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSP
KSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLET
LQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRS
MAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQG
HGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSS
CCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVE
NKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVG
VLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLF

--------------------------------------------------------------
>63754_63754_4_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000503258_PLK2_chr5_57754919_ENST00000274289_length(transcript)=3637nt_BP=1248nt
TTCTCACTGCCCTGCGGTGTTTTGAACTGCCTTCTTACAGACGTCATACAGCCCTTGAGGAATAGTTTCTGCCTGGTGAGATTGAATGAT
AGTTCTCATTCACAAAACCCTGGATTCTAAGCAGGGACACACAGAAATTACTTTCGCAGGTAAATCAGCCCACCCAGCCAAAGTGTGGAG
AGATTTGTTCCTTGGCTGACTTCTTTGCTCCACGGAGAGGAGTGTTTTCCTGTGCTTGCCCTGAAATGGAACTTCCTTGACAGCTCTCCC
GTGTTACAGTACCTCCCGGTCATTTTCTTTTTCTCTCTCTCTACCTGCGCTCTTCGAGTGTCAGAAACCTTTAAAGCTGTTACTATGGAA
TTGCAAAAAAGAGATCAAGTGACTCTTTCACTATGCTGGTTTCCCTTGTGACCCAGATGAAGAATCAATTCAGAATTCAGTTCCTCCCTT
GGCATTGCAAGACACAGAAGAAACTGTCACTTCCTAACAGCCTAGTACTGGAGTAAATTCAGTATGAAGGAAGAAAGCGCTCCTGCGTGT
TAGAACCTTGCCCATGAGCTGGACCGAGGACAGGAGATGGACTCCAGGAAAATTGGATTTCTTCAAGCAGCCTCCCTTGGAAATGGAATA
TCTTTAAAATCTTCTTTGCAGAAAGACAGTTAGAATGTATTAATCAGAATAGTTGAAGACTTATTTTCCTTTTTATTTTTTTTCAAAATG
AGCATTATTATGAAGCCAAGATCCCGATCTACAAGTTCCCTAAGGACTGCAGAGGCAGTTTGTTTTGATGTGGACAATGGCACATCTGCG
GGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTC
CTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTG
ATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCT
AGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTG
GAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGGGTGGCTTTGCA
AAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGTAGCTAAACCTCATCAAAGG
GAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTACTTCGAGGACAAAGAAAAC
ATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGACAGAGCCAGAAGTTCGATAC
TACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACTAGGGAACTTTTTTATTAAT
GAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAGAACGATATGTGGTACCCCA
AATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTGTGTAATGTATACAATGTTA
CTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATACAATGCCGTCCTCATTGCTG
GCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACATCATTCGACATGACTTTTTT
TTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAGCCCAGCTAAGAATTTCTTT
AAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGTGTCTAAAGAAGATGAAGAC
ATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGAGGAGCTCCAGCCACCTACC
ACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGATAGTCAGAGGGACTCTTGGC
AGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGTTCTTCGGGGATGTCTGGAA
AACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGTTGATTACTCTAACAAATAT
GGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCTTCCAGACAAAAAAACAGTT
CACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCAAGTGACGGTGCTGAAATAC
TTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACCTCGGCTCTACCTCCTTCAG
TGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGATCATACAAAAATCATCATC
TGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGACAACTCTGCTGATGTCTGGC
TGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAACTGAAAGACTTTTCGAATGGACCCTATG
GGACTCCTCTTTTCCACTGTGAGATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTTGAAGAAGATGGACATGTGGTGGTACGAAA
ACAATTCCCCTGTGGCCTGCTGGACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCTTGACTTTGGACAATCCAAGAGTGAACCAG
AATGCAGTTTTCCTTGAGATACCTGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGTGCATTGATTCTTAAATTCTCTCTGTTGAG
AGCATTTCAGCCAGAGGACTTTGGAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGGAGGAAGCTCCCATGTTGTTTAAAGGCTGT
AATTGGAGCAGCTTTTGGCTGCGTAACTGTGAACTATGGCCATATATAATTTTTTTTCATTAATTTTTGAAGATACTTGTGGCTGGAAAA
GTGCATTCCTTGTTAATAAACTTTTTATTTATTACAGCCCAAAGAGCAGTATTTATTATCAAAATGTCTTTTTTTTTATGTTGACCATTT

>63754_63754_4_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000503258_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=772AA_BP=0
MSIIMKPRSRSTSSLRTAEAVCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDD
LIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGF
AKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVR
YYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTM
LLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNF
FKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTL
GSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKT
VHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKII

--------------------------------------------------------------
>63754_63754_5_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000507116_PLK2_chr5_57754919_ENST00000274289_length(transcript)=3254nt_BP=865nt
AGAGAGACTGAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAAC
CACGTTGCCCTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGT
GGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGAC
AGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAA
CATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCAT
GACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTA
TGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGT
CTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAA
CCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGA
CCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTT
GACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGA
GCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTG
CAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGG
ACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGG
GGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCT
CAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAAC
TACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGC
TAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAG
ACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTT
TGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTT
GAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAAC
ACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATG
CCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCAT
TCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGA
CCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCA
ATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAA
CCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCT
AATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCT
TCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCG
AATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAACTGAAAGACTTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAG
ATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTTGAAGAAGATGGACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGG
ACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCTTGACTTTGGACAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACC
TGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGTGCATTGATTCTTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTG
GAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGGAGGAAGCTCCCATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCG
TAACTGTGAACTATGGCCATATATAATTTTTTTTCATTAATTTTTGAAGATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTT
TTTATTTATTACAGCCCAAAGAGCAGTATTTATTATCAAAATGTCTTTTTTTTTATGTTGACCATTTTAAACCGTTGGCAATAAAGAGTA

>63754_63754_5_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000507116_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=881AA_BP=1
MRQATECTNSSRLRPASLDISGTVSEGTTLPWILASCTKLTRKMAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTAR
KSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDL
SPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQL
ETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSR
RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK
QGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLS
SSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPA
VENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHT
VGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMM

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>63754_63754_6_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000546160_PLK2_chr5_57754919_ENST00000274289_length(transcript)=3127nt_BP=738nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCTCTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTC
CGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATATTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGAC
TTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCCTGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGT
GGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAAT
TTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCC
ATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCT
GCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAG
GCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGT
GAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCT
CACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAG
TTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGA
AAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGA
GATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAA
CACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGG
GCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAA
GCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGT
TTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTC
CACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACA
CATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACAC
AGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCT
ATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACA
GTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTC
ACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCAC
ATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAA
TTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGAT
ATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAAT
TTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACT
TTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGT
AACTGAAAGACTTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAGATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGT
TGAAGAAGATGGACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGGACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTC
TTGACTTTGGACAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACCTGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGG
TGCATTGATTCTTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTGGAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGG
GAGGAAGCTCCCATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCGTAACTGTGAACTATGGCCATATATAATTTTTTTTCAT
TAATTTTTGAAGATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTTTTTATTTATTACAGCCCAAAGAGCAGTATTTATTATC

>63754_63754_6_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000546160_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=841AA_BP=0
MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS
GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA
ALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIP
HSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR
DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIRE
ARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDT
HNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADT
VARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQ
FISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTT

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Fusion Gene PPI Analysis for PDE4D-PLK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDE4D-PLK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDE4D-PLK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource