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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDE4D-RFWD2 (FusionGDB2 ID:63759)

Fusion Gene Summary for PDE4D-RFWD2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4D-RFWD2
Fusion gene ID: 63759
HgeneTgene
Gene symbol

PDE4D

RFWD2

Gene ID

5144

64326

Gene namephosphodiesterase 4DCOP1 E3 ubiquitin ligase
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1CFAP78|FAP78|RFWD2|RNF200
Cytomap

5q11.2-q12.1

1q25.1-q25.2

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136E3 ubiquitin-protein ligase COP1E3 ubiquitin-protein ligase RFWD2RING finger protein 200RING-type E3 ubiquitin transferase RFWD2constitutive photomorphogenesis protein 1 homologconstitutive photomorphogenic protein 1putative ubiquitin ligase COP1ri
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000502575, ENST00000507116, 
ENST00000317118, ENST00000340635, 
ENST00000358923, ENST00000360047, 
ENST00000405755, ENST00000502484, 
ENST00000503258, ENST00000503947, 
ENST00000546160, 		ENST00000308769, 
ENST00000367669, 
Fusion gene scores* DoF score40 X 32 X 12=1536028 X 17 X 12=5712
# samples 5627
** MAII scorelog2(56/15360*10)=-4.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/5712*10)=-4.40296466697827
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE4D [Title/Abstract] AND RFWD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDE4D(59064073)-RFWD2(175916375), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRFWD2

GO:0010212

response to ionizing radiation

19805145


check buttonFusion gene breakpoints across PDE4D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RFWD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-L9-A5IP-01APDE4Dchr5

59064073

-RFWD2chr1

175916375

-
ChimerDB4LUADTCGA-L9-A5IPPDE4Dchr5

59064073

-RFWD2chr1

175916375

-


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Fusion Gene ORF analysis for PDE4D-RFWD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000502575ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
In-frameENST00000502575ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
In-frameENST00000507116ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
In-frameENST00000507116ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000317118ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000317118ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000340635ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000340635ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000358923ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000358923ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000360047ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000360047ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000405755ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000405755ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000502484ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000502484ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000503258ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000503258ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000503947ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000503947ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000546160ENST00000308769PDE4Dchr5

59064073

-RFWD2chr1

175916375

-
intron-3CDSENST00000546160ENST00000367669PDE4Dchr5

59064073

-RFWD2chr1

175916375

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000507116PDE4Dchr559064073-ENST00000367669RFWD2chr1175916375-7843997414135
ENST00000507116PDE4Dchr559064073-ENST00000308769RFWD2chr1175916375-4623997414135
ENST00000502575PDE4Dchr559064073-ENST00000367669RFWD2chr1175916375-77539049405118
ENST00000502575PDE4Dchr559064073-ENST00000308769RFWD2chr1175916375-45339049405118

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000507116ENST00000367669PDE4Dchr559064073-RFWD2chr1175916375-0.53164690.46835303
ENST00000507116ENST00000308769PDE4Dchr559064073-RFWD2chr1175916375-0.20380130.7961987
ENST00000502575ENST00000367669PDE4Dchr559064073-RFWD2chr1175916375-0.511569140.48843086
ENST00000502575ENST00000308769PDE4Dchr559064073-RFWD2chr1175916375-0.180883690.81911635

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Fusion Genomic Features for PDE4D-RFWD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDE4D-RFWD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:59064073/chr1:175916375)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:59064073chr1:175916375ENST00000502575-1642_8887220.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000507116-11542_8887746.0Compositional biasNote=Pro-rich
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619691_729687708.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:59064073chr1:175916375ENST00000317118-11042_880519.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000340635-11542_880810.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000358923-11142_880508.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000360047-11542_880674.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000405755-11542_880688.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000502484-11742_880749.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000503258-11542_880680.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000546160-11642_880749.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59064073chr1:175916375ENST00000317118-110386_7150519.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000340635-115386_7150810.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000358923-111386_7150508.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000360047-115386_7150674.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000405755-115386_7150688.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000502484-117386_7150749.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000502575-16386_71587220.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000503258-115386_7150680.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000507116-115386_71587746.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000546160-116386_7150749.0DomainPDEase
HgenePDE4Dchr5:59064073chr1:175916375ENST00000317118-110462_4660519.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000340635-115462_4660810.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000358923-111462_4660508.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000360047-115462_4660674.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000405755-115462_4660688.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000502484-117462_4660749.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000502575-16462_46687220.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000503258-115462_4660680.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000507116-115462_46687746.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59064073chr1:175916375ENST00000546160-116462_4660749.0Nucleotide bindingcAMP
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619233_301687708.0Coiled coilOntology_term=ECO:0000255
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720233_301711732.0Coiled coilOntology_term=ECO:0000255
TgeneRFWD2chr5:59064073chr1:175916375ENST0000030876916192_110687708.0Compositional biasNote=Ser-rich
TgeneRFWD2chr5:59064073chr1:175916375ENST0000036766917202_110711732.0Compositional biasNote=Ser-rich
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619109_113687708.0MotifNote=Nuclear localization signal 1
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619195_206687708.0MotifNote=Nuclear localization signal 2
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619235_245687708.0MotifNuclear export signal
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720109_113711732.0MotifNote=Nuclear localization signal 1
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720195_206711732.0MotifNote=Nuclear localization signal 2
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720235_245711732.0MotifNuclear export signal
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619419_458687708.0RepeatNote=WD 1
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619468_508687708.0RepeatNote=WD 2
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619511_551687708.0RepeatNote=WD 3
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619553_593687708.0RepeatNote=WD 4
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619597_635687708.0RepeatNote=WD 5
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619638_677687708.0RepeatNote=WD 6
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720419_458711732.0RepeatNote=WD 1
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720468_508711732.0RepeatNote=WD 2
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720511_551711732.0RepeatNote=WD 3
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720553_593711732.0RepeatNote=WD 4
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720597_635711732.0RepeatNote=WD 5
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720638_677711732.0RepeatNote=WD 6
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720691_729711732.0RepeatNote=WD 7
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619136_174687708.0Zinc fingerRING-type
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720136_174711732.0Zinc fingerRING-type


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Fusion Gene Sequence for PDE4D-RFWD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63759_63759_1_PDE4D-RFWD2_PDE4D_chr5_59064073_ENST00000502575_RFWD2_chr1_175916375_ENST00000308769_length(transcript)=453nt_BP=390nt
GAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAACCACGTTGCC
CTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGTGGATAATCC
GCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGACAGCGAGGAA
ATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAACATCCCCAA
ACAGCGGCGTTTCACGGTGGCACATACATGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGGTACAATTAAGGTGCTAGAATTGGTA

>63759_63759_1_PDE4D-RFWD2_PDE4D_chr5_59064073_ENST00000502575_RFWD2_chr1_175916375_ENST00000308769_length(amino acids)=118AA_BP=
MDISGTVSEGTTLPWILASCTKLTRKMAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSP

--------------------------------------------------------------
>63759_63759_2_PDE4D-RFWD2_PDE4D_chr5_59064073_ENST00000502575_RFWD2_chr1_175916375_ENST00000367669_length(transcript)=775nt_BP=390nt
GAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAACCACGTTGCC
CTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGTGGATAATCC
GCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGACAGCGAGGAA
ATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAACATCCCCAA
ACAGCGGCGTTTCACGGTGGCACATACATGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGGTACAATTAAGGTGCTAGAATTGGTA
TGAAGGGTTAACTCAAGTCAAATTGTACTTGATCCTGCTGAAATACATCTGCAGCTGACAATGAGAGAAGAAACAGAAAATGTCATGTGA
TGTCTCTCCCCAAAGTCATCATGGGTTTTGGATTTGTTTTGAATATTTTTTTCTTTTTTTCTTTTCCCTCCTTTATGACCTTTGGGACAT
TGGGAATACCCAGCCAACTCTCCACCATCAATGTAACTCCATGGACATTGCTGCTCTTGGTGGTGTTATCTAATTTTTGTGATAGGGAAA

>63759_63759_2_PDE4D-RFWD2_PDE4D_chr5_59064073_ENST00000502575_RFWD2_chr1_175916375_ENST00000367669_length(amino acids)=118AA_BP=
MDISGTVSEGTTLPWILASCTKLTRKMAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSP

--------------------------------------------------------------
>63759_63759_3_PDE4D-RFWD2_PDE4D_chr5_59064073_ENST00000507116_RFWD2_chr1_175916375_ENST00000308769_length(transcript)=462nt_BP=399nt
AGAGAGACTGAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAAC
CACGTTGCCCTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGT
GGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGAC
AGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAA
CATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGGTACAATTAAGGTGCTA

>63759_63759_3_PDE4D-RFWD2_PDE4D_chr5_59064073_ENST00000507116_RFWD2_chr1_175916375_ENST00000308769_length(amino acids)=135AA_BP=
MRQATECTNSSRLRPASLDISGTVSEGTTLPWILASCTKLTRKMAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTAR

--------------------------------------------------------------
>63759_63759_4_PDE4D-RFWD2_PDE4D_chr5_59064073_ENST00000507116_RFWD2_chr1_175916375_ENST00000367669_length(transcript)=784nt_BP=399nt
AGAGAGACTGAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAAC
CACGTTGCCCTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGT
GGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGAC
AGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAA
CATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGGTACAATTAAGGTGCTA
GAATTGGTATGAAGGGTTAACTCAAGTCAAATTGTACTTGATCCTGCTGAAATACATCTGCAGCTGACAATGAGAGAAGAAACAGAAAAT
GTCATGTGATGTCTCTCCCCAAAGTCATCATGGGTTTTGGATTTGTTTTGAATATTTTTTTCTTTTTTTCTTTTCCCTCCTTTATGACCT
TTGGGACATTGGGAATACCCAGCCAACTCTCCACCATCAATGTAACTCCATGGACATTGCTGCTCTTGGTGGTGTTATCTAATTTTTGTG

>63759_63759_4_PDE4D-RFWD2_PDE4D_chr5_59064073_ENST00000507116_RFWD2_chr1_175916375_ENST00000367669_length(amino acids)=135AA_BP=
MRQATECTNSSRLRPASLDISGTVSEGTTLPWILASCTKLTRKMAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTAR

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Fusion Gene PPI Analysis for PDE4D-RFWD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRFWD2chr5:59064073chr1:175916375ENST000003087691619643_645687.0708.0TRIB1
TgeneRFWD2chr5:59064073chr1:175916375ENST000003676691720643_645711.0732.0TRIB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDE4D-RFWD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDE4D-RFWD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource