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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDE8A-CIB1 (FusionGDB2 ID:63802)

Fusion Gene Summary for PDE8A-CIB1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE8A-CIB1
Fusion gene ID: 63802
HgeneTgene
Gene symbol

PDE8A

CIB1

Gene ID

5151

10519

Gene namephosphodiesterase 8Acalcium and integrin binding 1
SynonymsHsT19550CIB|CIBP|KIP1|PRKDCIP|SIP2-28
Cytomap

15q25.3

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionhigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AcAMP-specific cyclic nucleotide phosphodiesterase 8Acalcium and integrin-binding protein 1DNA-PK interaction proteinDNA-PKcs-interacting proteinDNA-dependent protein kinase interacting proteinSNK-interacting protein 2-28calcium and integrin binding 1 (calmyrin)testicular secretory protein Li 9
Modification date2020031320200313
UniProtAcc.

Q99828

Ensembl transtripts involved in fusion geneENST00000310298, ENST00000339708, 
ENST00000394553, ENST00000557819, 
ENST00000557957, 		ENST00000328649, 
Fusion gene scores* DoF score11 X 11 X 6=7264 X 5 X 2=40
# samples 146
** MAII scorelog2(14/726*10)=-2.37454272105078
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDE8A [Title/Abstract] AND CIB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDE8A(85525579)-CIB1(90776935), # samples:3
Anticipated loss of major functional domain due to fusion event.PDE8A-CIB1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PDE8A-CIB1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCIB1

GO:0006974

cellular response to DNA damage stimulus

12011095

TgeneCIB1

GO:0007026

negative regulation of microtubule depolymerization

21215777

TgeneCIB1

GO:0007113

endomitotic cell cycle

21264284

TgeneCIB1

GO:0010977

negative regulation of neuron projection development

21215777

TgeneCIB1

GO:0033630

positive regulation of cell adhesion mediated by integrin

11756406

TgeneCIB1

GO:0070886

positive regulation of calcineurin-NFAT signaling cascade

20639889

TgeneCIB1

GO:1900026

positive regulation of substrate adhesion-dependent cell spreading

11756406

TgeneCIB1

GO:1990090

cellular response to nerve growth factor stimulus

21215777


check buttonFusion gene breakpoints across PDE8A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CIB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0IO-01APDE8Achr15

85525579

+CIB1chr15

90774445

-
ChimerDB4BRCATCGA-B6-A0IO-01APDE8Achr15

85525579

+CIB1chr15

90774739

-
ChimerDB4BRCATCGA-B6-A0IO-01APDE8Achr15

85525579

+CIB1chr15

90776935

-
ChimerDB4BRCATCGA-B6-A0IOPDE8Achr15

85525579

+CIB1chr15

90774739

-
ChimerDB4BRCATCGA-B6-A0IOPDE8Achr15

85525579

+CIB1chr15

90776935

-


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Fusion Gene ORF analysis for PDE8A-CIB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000310298ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774445

-
Frame-shiftENST00000339708ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774445

-
Frame-shiftENST00000394553ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774445

-
In-frameENST00000310298ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90776935

-
In-frameENST00000310298ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774739

-
In-frameENST00000339708ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90776935

-
In-frameENST00000339708ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774739

-
In-frameENST00000394553ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90776935

-
In-frameENST00000394553ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774739

-
intron-3CDSENST00000557819ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774445

-
intron-3CDSENST00000557819ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90776935

-
intron-3CDSENST00000557819ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774739

-
intron-3CDSENST00000557957ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774445

-
intron-3CDSENST00000557957ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90776935

-
intron-3CDSENST00000557957ENST00000328649PDE8Achr15

85525579

+CIB1chr15

90774739

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310298PDE8Achr1585525579+ENST00000328649CIB1chr1590776935-1472438252962236
ENST00000394553PDE8Achr1585525579+ENST00000328649CIB1chr1590776935-1409375189899236
ENST00000339708PDE8Achr1585525579+ENST00000328649CIB1chr1590776935-1402368182892236
ENST00000310298PDE8Achr1585525579+ENST00000328649CIB1chr1590774739-1328438252818188
ENST00000394553PDE8Achr1585525579+ENST00000328649CIB1chr1590774739-1265375189755188
ENST00000339708PDE8Achr1585525579+ENST00000328649CIB1chr1590774739-1258368182748188

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310298ENST00000328649PDE8Achr1585525579+CIB1chr1590776935-0.0051713810.99482864
ENST00000394553ENST00000328649PDE8Achr1585525579+CIB1chr1590776935-0.0054598340.99454015
ENST00000339708ENST00000328649PDE8Achr1585525579+CIB1chr1590776935-0.005841780.99415827
ENST00000310298ENST00000328649PDE8Achr1585525579+CIB1chr1590774739-0.0035104320.9964896
ENST00000394553ENST00000328649PDE8Achr1585525579+CIB1chr1590774739-0.0033887140.9966113
ENST00000339708ENST00000328649PDE8Achr1585525579+CIB1chr1590774739-0.0036330080.996367

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Fusion Genomic Features for PDE8A-CIB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDE8A-CIB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:85525579/chr15:90776935)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CIB1

Q99828

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.; FUNCTION: [Isoform 2]: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion. {ECO:0000269|PubMed:23503467}.; FUNCTION: (Microbial infection) Involved in keratinocyte-intrinsic immunity to human beta-papillomaviruses (HPVs). {ECO:0000269|PubMed:30068544}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCIB1chr15:85525579chr15:90774739ENST0000032864927116_12765192.0Calcium bindingNote=1
TgeneCIB1chr15:85525579chr15:90774739ENST0000032864927161_17265192.0Calcium bindingNote=2
TgeneCIB1chr15:85525579chr15:90776935ENST0000032864907116_12717192.0Calcium bindingNote=1
TgeneCIB1chr15:85525579chr15:90776935ENST0000032864907161_17217192.0Calcium bindingNote=2
TgeneCIB1chr15:85525579chr15:90774739ENST0000032864927103_13865192.0DomainEF-hand 1
TgeneCIB1chr15:85525579chr15:90774739ENST0000032864927148_18365192.0DomainEF-hand 2
TgeneCIB1chr15:85525579chr15:90776935ENST0000032864907103_13817192.0DomainEF-hand 1
TgeneCIB1chr15:85525579chr15:90776935ENST0000032864907148_18317192.0DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE8Achr15:85525579chr15:90774739ENST00000310298+223213_28362830.0DomainPAS
HgenePDE8Achr15:85525579chr15:90774739ENST00000310298+223287_32962830.0DomainNote=PAC
HgenePDE8Achr15:85525579chr15:90774739ENST00000310298+223480_82062830.0DomainPDEase
HgenePDE8Achr15:85525579chr15:90774739ENST00000339708+121213_28362784.0DomainPAS
HgenePDE8Achr15:85525579chr15:90774739ENST00000339708+121287_32962784.0DomainNote=PAC
HgenePDE8Achr15:85525579chr15:90774739ENST00000339708+121480_82062784.0DomainPDEase
HgenePDE8Achr15:85525579chr15:90774739ENST00000394553+122213_28362830.0DomainPAS
HgenePDE8Achr15:85525579chr15:90774739ENST00000394553+122287_32962830.0DomainNote=PAC
HgenePDE8Achr15:85525579chr15:90774739ENST00000394553+122480_82062830.0DomainPDEase
HgenePDE8Achr15:85525579chr15:90774739ENST00000557957+122213_2830758.0DomainPAS
HgenePDE8Achr15:85525579chr15:90774739ENST00000557957+122287_3290758.0DomainNote=PAC
HgenePDE8Achr15:85525579chr15:90774739ENST00000557957+122480_8200758.0DomainPDEase
HgenePDE8Achr15:85525579chr15:90776935ENST00000310298+223213_28362830.0DomainPAS
HgenePDE8Achr15:85525579chr15:90776935ENST00000310298+223287_32962830.0DomainNote=PAC
HgenePDE8Achr15:85525579chr15:90776935ENST00000310298+223480_82062830.0DomainPDEase
HgenePDE8Achr15:85525579chr15:90776935ENST00000339708+121213_28362784.0DomainPAS
HgenePDE8Achr15:85525579chr15:90776935ENST00000339708+121287_32962784.0DomainNote=PAC
HgenePDE8Achr15:85525579chr15:90776935ENST00000339708+121480_82062784.0DomainPDEase
HgenePDE8Achr15:85525579chr15:90776935ENST00000394553+122213_28362830.0DomainPAS
HgenePDE8Achr15:85525579chr15:90776935ENST00000394553+122287_32962830.0DomainNote=PAC
HgenePDE8Achr15:85525579chr15:90776935ENST00000394553+122480_82062830.0DomainPDEase
HgenePDE8Achr15:85525579chr15:90776935ENST00000557957+122213_2830758.0DomainPAS
HgenePDE8Achr15:85525579chr15:90776935ENST00000557957+122287_3290758.0DomainNote=PAC
HgenePDE8Achr15:85525579chr15:90776935ENST00000557957+122480_8200758.0DomainPDEase
HgenePDE8Achr15:85525579chr15:90774739ENST00000310298+223454_46162830.0RegionInvolved in RAF1-binding
HgenePDE8Achr15:85525579chr15:90774739ENST00000339708+121454_46162784.0RegionInvolved in RAF1-binding
HgenePDE8Achr15:85525579chr15:90774739ENST00000394553+122454_46162830.0RegionInvolved in RAF1-binding
HgenePDE8Achr15:85525579chr15:90774739ENST00000557957+122454_4610758.0RegionInvolved in RAF1-binding
HgenePDE8Achr15:85525579chr15:90776935ENST00000310298+223454_46162830.0RegionInvolved in RAF1-binding
HgenePDE8Achr15:85525579chr15:90776935ENST00000339708+121454_46162784.0RegionInvolved in RAF1-binding
HgenePDE8Achr15:85525579chr15:90776935ENST00000394553+122454_46162830.0RegionInvolved in RAF1-binding
HgenePDE8Achr15:85525579chr15:90776935ENST00000557957+122454_4610758.0RegionInvolved in RAF1-binding


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Fusion Gene Sequence for PDE8A-CIB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63802_63802_1_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000310298_CIB1_chr15_90774739_ENST00000328649_length(transcript)=1328nt_BP=438nt
AGTAGCCGGGCCAAGGCGGGAGCGGCTGCCTCTCAGGGTCGCTCCAGGGCCGCGCTAGGAAAGCCGCCGCCGCCGCAGCGCCCGCACCGC
GATAAAAGGGGCGGCCGCGTTTCCTGACGCGAGATCCGCGCTCGCCGCCGCCCGCCCAGGCGGCGATGACACGGCGCCCGCGGCGGCCCG
GAGGCGCCGGGTGGGCCGTTTGCTGACCGGATCGCGGCTACCCGCCAGCGTGTCCGCGGCGCCGCCGCCAGCATGGGCTGTGCCCCGAGC
ATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGCCCCGCGGCACCGCCGCTGTCGTCCGGCGGGCCGCGCCTCCCGCAGGGC
CAGAAGACGGCCGCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGACGGCAGCGGCAAGAAGGCCAACCCCTTC
AAGGAGCGAATCTGCAGGGTCTTCTCCACATCCCCAGCCAAAGACAGCCTTAGCTTTGAGGACTTCCTGGATCTCCTCAGTGTGTTCAGT
GACACAGCCACGCCAGACATCAAGTCCCATTATGCCTTCCGCATCTTTGACTTTGATGATGACGGAACCTTGAACAGAGAAGACCTGAGC
CGGCTGGTGAACTGCCTCACGGGAGAGGGCGAGGACACACGGCTTAGTGCGTCTGAGATGAAGCAGCTCATCGACAACATCCTGGAGGAG
TCTGACATTGACAGGGATGGAACCATCAACCTCTCTGAGTTCCAGCACGTCATCTCCCGTTCTCCAGACTTTGCCAGCTCCTTTAAGATT
GTCCTGTGACAGCAGCCCCAGCGTGTGTCCTGGCACCCTGTCCAAGAACCTTTCTACTGCTGAGCTGTGGCCAAGGTCAAGCCTGTGTTG
CCAGTGCGGGCCAAGCTGGCCCAGCCTGGAGCTGGCGCTGTGCAGCCTCACCCCGGGCAGGGGCGGCCCTCGTTGTCAGGGCCTCTCCTC
ACTGCTGTTGTCATTGCTCCGTTTGTGTTTGTACTAATCAGTAATAAAGGTTTAGAAGTTTGACCCTATGTGTGACATGAGATACACTGG
TATGAGGAAGGACTGGACTTCTCTTCTAAGAGCCTTCAATCATCCTAGGAATAAGCAGCATATCGAGCAGAGGCCAGCGGGAAGTCAAGC
CGCACCCACGCTGGCTGTCCCCGTGGGAGGGTGTGAGGATGAAGGGGCAGCAGGAGGTGTGGGACTCGCCTGTATCCTGATTGGGGTGGT

>63802_63802_1_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000310298_CIB1_chr15_90774739_ENST00000328649_length(amino acids)=188AA_BP=62
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKANPFKERICRVFSTSPAKDSLSFEDFLD
LLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDF

--------------------------------------------------------------
>63802_63802_2_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000310298_CIB1_chr15_90776935_ENST00000328649_length(transcript)=1472nt_BP=438nt
AGTAGCCGGGCCAAGGCGGGAGCGGCTGCCTCTCAGGGTCGCTCCAGGGCCGCGCTAGGAAAGCCGCCGCCGCCGCAGCGCCCGCACCGC
GATAAAAGGGGCGGCCGCGTTTCCTGACGCGAGATCCGCGCTCGCCGCCGCCCGCCCAGGCGGCGATGACACGGCGCCCGCGGCGGCCCG
GAGGCGCCGGGTGGGCCGTTTGCTGACCGGATCGCGGCTACCCGCCAGCGTGTCCGCGGCGCCGCCGCCAGCATGGGCTGTGCCCCGAGC
ATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGCCCCGCGGCACCGCCGCTGTCGTCCGGCGGGCCGCGCCTCCCGCAGGGC
CAGAAGACGGCCGCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGACGGCAGCGGCAAGAAGGACTTGACGTTC
CTGACGAAGCAGGAGATCCTCCTAGCCCACAGGCGGTTTTGTGAGCTGCTTCCCCAGGAGCAGCGGAGCGTGGAGTCGTCACTTCGGGCA
CAAGTGCCCTTCGAGCAGATTCTCAGCCTTCCAGAGCTCAAGGCCAACCCCTTCAAGGAGCGAATCTGCAGGGTCTTCTCCACATCCCCA
GCCAAAGACAGCCTTAGCTTTGAGGACTTCCTGGATCTCCTCAGTGTGTTCAGTGACACAGCCACGCCAGACATCAAGTCCCATTATGCC
TTCCGCATCTTTGACTTTGATGATGACGGAACCTTGAACAGAGAAGACCTGAGCCGGCTGGTGAACTGCCTCACGGGAGAGGGCGAGGAC
ACACGGCTTAGTGCGTCTGAGATGAAGCAGCTCATCGACAACATCCTGGAGGAGTCTGACATTGACAGGGATGGAACCATCAACCTCTCT
GAGTTCCAGCACGTCATCTCCCGTTCTCCAGACTTTGCCAGCTCCTTTAAGATTGTCCTGTGACAGCAGCCCCAGCGTGTGTCCTGGCAC
CCTGTCCAAGAACCTTTCTACTGCTGAGCTGTGGCCAAGGTCAAGCCTGTGTTGCCAGTGCGGGCCAAGCTGGCCCAGCCTGGAGCTGGC
GCTGTGCAGCCTCACCCCGGGCAGGGGCGGCCCTCGTTGTCAGGGCCTCTCCTCACTGCTGTTGTCATTGCTCCGTTTGTGTTTGTACTA
ATCAGTAATAAAGGTTTAGAAGTTTGACCCTATGTGTGACATGAGATACACTGGTATGAGGAAGGACTGGACTTCTCTTCTAAGAGCCTT
CAATCATCCTAGGAATAAGCAGCATATCGAGCAGAGGCCAGCGGGAAGTCAAGCCGCACCCACGCTGGCTGTCCCCGTGGGAGGGTGTGA
GGATGAAGGGGCAGCAGGAGGTGTGGGACTCGCCTGTATCCTGATTGGGGTGGTGGTTAGATGAGTCTCTGCATGCATCAAAATGTAAAG

>63802_63802_2_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000310298_CIB1_chr15_90776935_ENST00000328649_length(amino acids)=236AA_BP=62
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKDLTFLTKQEILLAHRRFCELLPQEQRSV
ESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCL

--------------------------------------------------------------
>63802_63802_3_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000339708_CIB1_chr15_90774739_ENST00000328649_length(transcript)=1258nt_BP=368nt
CGCCGCAGCGCCCGCACCGCGATAAAAGGGGCGGCCGCGTTTCCTGACGCGAGATCCGCGCTCGCCGCCGCCCGCCCAGGCGGCGATGAC
ACGGCGCCCGCGGCGGCCCGGAGGCGCCGGGTGGGCCGTTTGCTGACCGGATCGCGGCTACCCGCCAGCGTGTCCGCGGCGCCGCCGCCA
GCATGGGCTGTGCCCCGAGCATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGCCCCGCGGCACCGCCGCTGTCGTCCGGCG
GGCCGCGCCTCCCGCAGGGCCAGAAGACGGCCGCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGACGGCAGCG
GCAAGAAGGCCAACCCCTTCAAGGAGCGAATCTGCAGGGTCTTCTCCACATCCCCAGCCAAAGACAGCCTTAGCTTTGAGGACTTCCTGG
ATCTCCTCAGTGTGTTCAGTGACACAGCCACGCCAGACATCAAGTCCCATTATGCCTTCCGCATCTTTGACTTTGATGATGACGGAACCT
TGAACAGAGAAGACCTGAGCCGGCTGGTGAACTGCCTCACGGGAGAGGGCGAGGACACACGGCTTAGTGCGTCTGAGATGAAGCAGCTCA
TCGACAACATCCTGGAGGAGTCTGACATTGACAGGGATGGAACCATCAACCTCTCTGAGTTCCAGCACGTCATCTCCCGTTCTCCAGACT
TTGCCAGCTCCTTTAAGATTGTCCTGTGACAGCAGCCCCAGCGTGTGTCCTGGCACCCTGTCCAAGAACCTTTCTACTGCTGAGCTGTGG
CCAAGGTCAAGCCTGTGTTGCCAGTGCGGGCCAAGCTGGCCCAGCCTGGAGCTGGCGCTGTGCAGCCTCACCCCGGGCAGGGGCGGCCCT
CGTTGTCAGGGCCTCTCCTCACTGCTGTTGTCATTGCTCCGTTTGTGTTTGTACTAATCAGTAATAAAGGTTTAGAAGTTTGACCCTATG
TGTGACATGAGATACACTGGTATGAGGAAGGACTGGACTTCTCTTCTAAGAGCCTTCAATCATCCTAGGAATAAGCAGCATATCGAGCAG
AGGCCAGCGGGAAGTCAAGCCGCACCCACGCTGGCTGTCCCCGTGGGAGGGTGTGAGGATGAAGGGGCAGCAGGAGGTGTGGGACTCGCC

>63802_63802_3_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000339708_CIB1_chr15_90774739_ENST00000328649_length(amino acids)=188AA_BP=62
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKANPFKERICRVFSTSPAKDSLSFEDFLD
LLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDF

--------------------------------------------------------------
>63802_63802_4_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000339708_CIB1_chr15_90776935_ENST00000328649_length(transcript)=1402nt_BP=368nt
CGCCGCAGCGCCCGCACCGCGATAAAAGGGGCGGCCGCGTTTCCTGACGCGAGATCCGCGCTCGCCGCCGCCCGCCCAGGCGGCGATGAC
ACGGCGCCCGCGGCGGCCCGGAGGCGCCGGGTGGGCCGTTTGCTGACCGGATCGCGGCTACCCGCCAGCGTGTCCGCGGCGCCGCCGCCA
GCATGGGCTGTGCCCCGAGCATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGCCCCGCGGCACCGCCGCTGTCGTCCGGCG
GGCCGCGCCTCCCGCAGGGCCAGAAGACGGCCGCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGACGGCAGCG
GCAAGAAGGACTTGACGTTCCTGACGAAGCAGGAGATCCTCCTAGCCCACAGGCGGTTTTGTGAGCTGCTTCCCCAGGAGCAGCGGAGCG
TGGAGTCGTCACTTCGGGCACAAGTGCCCTTCGAGCAGATTCTCAGCCTTCCAGAGCTCAAGGCCAACCCCTTCAAGGAGCGAATCTGCA
GGGTCTTCTCCACATCCCCAGCCAAAGACAGCCTTAGCTTTGAGGACTTCCTGGATCTCCTCAGTGTGTTCAGTGACACAGCCACGCCAG
ACATCAAGTCCCATTATGCCTTCCGCATCTTTGACTTTGATGATGACGGAACCTTGAACAGAGAAGACCTGAGCCGGCTGGTGAACTGCC
TCACGGGAGAGGGCGAGGACACACGGCTTAGTGCGTCTGAGATGAAGCAGCTCATCGACAACATCCTGGAGGAGTCTGACATTGACAGGG
ATGGAACCATCAACCTCTCTGAGTTCCAGCACGTCATCTCCCGTTCTCCAGACTTTGCCAGCTCCTTTAAGATTGTCCTGTGACAGCAGC
CCCAGCGTGTGTCCTGGCACCCTGTCCAAGAACCTTTCTACTGCTGAGCTGTGGCCAAGGTCAAGCCTGTGTTGCCAGTGCGGGCCAAGC
TGGCCCAGCCTGGAGCTGGCGCTGTGCAGCCTCACCCCGGGCAGGGGCGGCCCTCGTTGTCAGGGCCTCTCCTCACTGCTGTTGTCATTG
CTCCGTTTGTGTTTGTACTAATCAGTAATAAAGGTTTAGAAGTTTGACCCTATGTGTGACATGAGATACACTGGTATGAGGAAGGACTGG
ACTTCTCTTCTAAGAGCCTTCAATCATCCTAGGAATAAGCAGCATATCGAGCAGAGGCCAGCGGGAAGTCAAGCCGCACCCACGCTGGCT
GTCCCCGTGGGAGGGTGTGAGGATGAAGGGGCAGCAGGAGGTGTGGGACTCGCCTGTATCCTGATTGGGGTGGTGGTTAGATGAGTCTCT

>63802_63802_4_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000339708_CIB1_chr15_90776935_ENST00000328649_length(amino acids)=236AA_BP=62
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKDLTFLTKQEILLAHRRFCELLPQEQRSV
ESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCL

--------------------------------------------------------------
>63802_63802_5_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000394553_CIB1_chr15_90774739_ENST00000328649_length(transcript)=1265nt_BP=375nt
CCGCCGCCGCCGCAGCGCCCGCACCGCGATAAAAGGGGCGGCCGCGTTTCCTGACGCGAGATCCGCGCTCGCCGCCGCCCGCCCAGGCGG
CGATGACACGGCGCCCGCGGCGGCCCGGAGGCGCCGGGTGGGCCGTTTGCTGACCGGATCGCGGCTACCCGCCAGCGTGTCCGCGGCGCC
GCCGCCAGCATGGGCTGTGCCCCGAGCATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGCCCCGCGGCACCGCCGCTGTCG
TCCGGCGGGCCGCGCCTCCCGCAGGGCCAGAAGACGGCCGCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGAC
GGCAGCGGCAAGAAGGCCAACCCCTTCAAGGAGCGAATCTGCAGGGTCTTCTCCACATCCCCAGCCAAAGACAGCCTTAGCTTTGAGGAC
TTCCTGGATCTCCTCAGTGTGTTCAGTGACACAGCCACGCCAGACATCAAGTCCCATTATGCCTTCCGCATCTTTGACTTTGATGATGAC
GGAACCTTGAACAGAGAAGACCTGAGCCGGCTGGTGAACTGCCTCACGGGAGAGGGCGAGGACACACGGCTTAGTGCGTCTGAGATGAAG
CAGCTCATCGACAACATCCTGGAGGAGTCTGACATTGACAGGGATGGAACCATCAACCTCTCTGAGTTCCAGCACGTCATCTCCCGTTCT
CCAGACTTTGCCAGCTCCTTTAAGATTGTCCTGTGACAGCAGCCCCAGCGTGTGTCCTGGCACCCTGTCCAAGAACCTTTCTACTGCTGA
GCTGTGGCCAAGGTCAAGCCTGTGTTGCCAGTGCGGGCCAAGCTGGCCCAGCCTGGAGCTGGCGCTGTGCAGCCTCACCCCGGGCAGGGG
CGGCCCTCGTTGTCAGGGCCTCTCCTCACTGCTGTTGTCATTGCTCCGTTTGTGTTTGTACTAATCAGTAATAAAGGTTTAGAAGTTTGA
CCCTATGTGTGACATGAGATACACTGGTATGAGGAAGGACTGGACTTCTCTTCTAAGAGCCTTCAATCATCCTAGGAATAAGCAGCATAT
CGAGCAGAGGCCAGCGGGAAGTCAAGCCGCACCCACGCTGGCTGTCCCCGTGGGAGGGTGTGAGGATGAAGGGGCAGCAGGAGGTGTGGG
ACTCGCCTGTATCCTGATTGGGGTGGTGGTTAGATGAGTCTCTGCATGCATCAAAATGTAAAGAACCGTACATCAGTAAAGTCTATTTTA

>63802_63802_5_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000394553_CIB1_chr15_90774739_ENST00000328649_length(amino acids)=188AA_BP=62
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKANPFKERICRVFSTSPAKDSLSFEDFLD
LLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDF

--------------------------------------------------------------
>63802_63802_6_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000394553_CIB1_chr15_90776935_ENST00000328649_length(transcript)=1409nt_BP=375nt
CCGCCGCCGCCGCAGCGCCCGCACCGCGATAAAAGGGGCGGCCGCGTTTCCTGACGCGAGATCCGCGCTCGCCGCCGCCCGCCCAGGCGG
CGATGACACGGCGCCCGCGGCGGCCCGGAGGCGCCGGGTGGGCCGTTTGCTGACCGGATCGCGGCTACCCGCCAGCGTGTCCGCGGCGCC
GCCGCCAGCATGGGCTGTGCCCCGAGCATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGCCCCGCGGCACCGCCGCTGTCG
TCCGGCGGGCCGCGCCTCCCGCAGGGCCAGAAGACGGCCGCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGAC
GGCAGCGGCAAGAAGGACTTGACGTTCCTGACGAAGCAGGAGATCCTCCTAGCCCACAGGCGGTTTTGTGAGCTGCTTCCCCAGGAGCAG
CGGAGCGTGGAGTCGTCACTTCGGGCACAAGTGCCCTTCGAGCAGATTCTCAGCCTTCCAGAGCTCAAGGCCAACCCCTTCAAGGAGCGA
ATCTGCAGGGTCTTCTCCACATCCCCAGCCAAAGACAGCCTTAGCTTTGAGGACTTCCTGGATCTCCTCAGTGTGTTCAGTGACACAGCC
ACGCCAGACATCAAGTCCCATTATGCCTTCCGCATCTTTGACTTTGATGATGACGGAACCTTGAACAGAGAAGACCTGAGCCGGCTGGTG
AACTGCCTCACGGGAGAGGGCGAGGACACACGGCTTAGTGCGTCTGAGATGAAGCAGCTCATCGACAACATCCTGGAGGAGTCTGACATT
GACAGGGATGGAACCATCAACCTCTCTGAGTTCCAGCACGTCATCTCCCGTTCTCCAGACTTTGCCAGCTCCTTTAAGATTGTCCTGTGA
CAGCAGCCCCAGCGTGTGTCCTGGCACCCTGTCCAAGAACCTTTCTACTGCTGAGCTGTGGCCAAGGTCAAGCCTGTGTTGCCAGTGCGG
GCCAAGCTGGCCCAGCCTGGAGCTGGCGCTGTGCAGCCTCACCCCGGGCAGGGGCGGCCCTCGTTGTCAGGGCCTCTCCTCACTGCTGTT
GTCATTGCTCCGTTTGTGTTTGTACTAATCAGTAATAAAGGTTTAGAAGTTTGACCCTATGTGTGACATGAGATACACTGGTATGAGGAA
GGACTGGACTTCTCTTCTAAGAGCCTTCAATCATCCTAGGAATAAGCAGCATATCGAGCAGAGGCCAGCGGGAAGTCAAGCCGCACCCAC
GCTGGCTGTCCCCGTGGGAGGGTGTGAGGATGAAGGGGCAGCAGGAGGTGTGGGACTCGCCTGTATCCTGATTGGGGTGGTGGTTAGATG

>63802_63802_6_PDE8A-CIB1_PDE8A_chr15_85525579_ENST00000394553_CIB1_chr15_90776935_ENST00000328649_length(amino acids)=236AA_BP=62
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKDLTFLTKQEILLAHRRFCELLPQEQRSV
ESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDE8A-CIB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDE8A-CIB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDE8A-CIB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource