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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDGFB-DGCR2 (FusionGDB2 ID:63834)

Fusion Gene Summary for PDGFB-DGCR2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDGFB-DGCR2
Fusion gene ID: 63834
HgeneTgene
Gene symbol

PDGFB

DGCR2

Gene ID

5155

9993

Gene nameplatelet derived growth factor subunit BDiGeorge syndrome critical region gene 2
SynonymsIBGC5|PDGF-2|PDGF2|SIS|SSV|c-sisDGS-C|IDD|LAN|SEZ-12
Cytomap

22q13.1

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionplatelet-derived growth factor subunit BPDGF subunit BPDGF, B chainbecaplerminepididymis secretory sperm binding proteinplatelet-derived growth factor 2platelet-derived growth factor B chainplatelet-derived growth factor beta polypeptide (simian saintegral membrane protein DGCR2/IDDDiGeorge syndrome critical region protein 2integral membrane protein deleted in DiGeorge syndrome
Modification date2020031320200313
UniProtAcc.

P98153

Ensembl transtripts involved in fusion geneENST00000331163, ENST00000381551, 
ENST00000263196, ENST00000473832, 
ENST00000537045, ENST00000545799, 
Fusion gene scores* DoF score4 X 5 X 3=6010 X 10 X 5=500
# samples 511
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/500*10)=-2.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDGFB [Title/Abstract] AND DGCR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDGFB(39626089)-DGCR2(19077003), # samples:3
Anticipated loss of major functional domain due to fusion event.PDGFB-DGCR2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PDGFB-DGCR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDGFB

GO:0001938

positive regulation of endothelial cell proliferation

9685360

HgenePDGFB

GO:0002548

monocyte chemotaxis

17991872

HgenePDGFB

GO:0006468

protein phosphorylation

17942966

HgenePDGFB

GO:0008284

positive regulation of cell proliferation

2439522|2836953|7073684

HgenePDGFB

GO:0009611

response to wounding

2538439

HgenePDGFB

GO:0010512

negative regulation of phosphatidylinositol biosynthetic process

2538439

HgenePDGFB

GO:0010544

negative regulation of platelet activation

2538439

HgenePDGFB

GO:0010628

positive regulation of gene expression

23554459|24008408

HgenePDGFB

GO:0010629

negative regulation of gene expression

23554459|25089138

HgenePDGFB

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

10734101|11788434|17942966

HgenePDGFB

GO:0014911

positive regulation of smooth muscle cell migration

9409235

HgenePDGFB

GO:0018105

peptidyl-serine phosphorylation

16530387

HgenePDGFB

GO:0018108

peptidyl-tyrosine phosphorylation

10734101|16530387

HgenePDGFB

GO:0030335

positive regulation of cell migration

11788434|21245381

HgenePDGFB

GO:0031954

positive regulation of protein autophosphorylation

12070119|16530387

HgenePDGFB

GO:0032091

negative regulation of protein binding

22619279

HgenePDGFB

GO:0032147

activation of protein kinase activity

16530387

HgenePDGFB

GO:0032148

activation of protein kinase B activity

16530387

HgenePDGFB

GO:0035655

interleukin-18-mediated signaling pathway

21321938

HgenePDGFB

GO:0035793

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

19019919

HgenePDGFB

GO:0043406

positive regulation of MAP kinase activity

9685360|11788434|16530387|17942966

HgenePDGFB

GO:0043536

positive regulation of blood vessel endothelial cell migration

9685360

HgenePDGFB

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

16530387

HgenePDGFB

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

16530387

HgenePDGFB

GO:0045840

positive regulation of mitotic nuclear division

10644978|10734101|17942966

HgenePDGFB

GO:0045892

negative regulation of transcription, DNA-templated

16530387|25089138

HgenePDGFB

GO:0045893

positive regulation of transcription, DNA-templated

16530387|17324121

HgenePDGFB

GO:0048008

platelet-derived growth factor receptor signaling pathway

2439522|2536956|2836953|19088079|21245381|23554459

HgenePDGFB

GO:0048146

positive regulation of fibroblast proliferation

2439522|10644978|17324121

HgenePDGFB

GO:0048661

positive regulation of smooth muscle cell proliferation

21321938

HgenePDGFB

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

21245381

HgenePDGFB

GO:0050921

positive regulation of chemotaxis

9409235|19019919

HgenePDGFB

GO:0060326

cell chemotaxis

16014047|17991872|21245381

HgenePDGFB

GO:0061098

positive regulation of protein tyrosine kinase activity

16530387

HgenePDGFB

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11788434|16530387|17942966

HgenePDGFB

GO:0071363

cellular response to growth factor stimulus

21245381

HgenePDGFB

GO:0072126

positive regulation of glomerular mesangial cell proliferation

11788434|16014047

HgenePDGFB

GO:0090280

positive regulation of calcium ion import

19019919

HgenePDGFB

GO:1900127

positive regulation of hyaluronan biosynthetic process

17324121

HgenePDGFB

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

26493107

HgenePDGFB

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

19088079

HgenePDGFB

GO:1904707

positive regulation of vascular smooth muscle cell proliferation

12070119|19088079|23554459

HgenePDGFB

GO:1904754

positive regulation of vascular associated smooth muscle cell migration

12070119|19088079|23554459

HgenePDGFB

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

19088079

HgenePDGFB

GO:1905176

positive regulation of vascular smooth muscle cell dedifferentiation

19088079

HgenePDGFB

GO:2000379

positive regulation of reactive oxygen species metabolic process

19019919

HgenePDGFB

GO:2000573

positive regulation of DNA biosynthetic process

10644978|10734101|11788434|12070119|16530387|17942966|19019919

HgenePDGFB

GO:2000591

positive regulation of metanephric mesenchymal cell migration

10734101


check buttonFusion gene breakpoints across PDGFB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DGCR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A84J-01APDGFBchr22

39626088

-DGCR2chr22

19055737

-
ChimerDB4LGGTCGA-TM-A84J-01APDGFBchr22

39626088

-DGCR2chr22

19077002

-
ChimerDB4LGGTCGA-TM-A84J-01APDGFBchr22

39626089

-DGCR2chr22

19077003

-
ChimerDB4LGGTCGA-TM-A84JPDGFBchr22

39626088

-DGCR2chr22

19055738

-
ChimerDB4LGGTCGA-TM-A84JPDGFBchr22

39626088

-DGCR2chr22

19077003

-
ChimerDB4LGGTCGA-TM-A84JPDGFBchr22

39626089

-DGCR2chr22

19077003

-


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Fusion Gene ORF analysis for PDGFB-DGCR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000331163ENST00000263196PDGFBchr22

39626088

-DGCR2chr22

19077002

-
5CDS-intronENST00000331163ENST00000263196PDGFBchr22

39626089

-DGCR2chr22

19077003

-
5CDS-intronENST00000331163ENST00000263196PDGFBchr22

39626088

-DGCR2chr22

19077003

-
5CDS-intronENST00000331163ENST00000473832PDGFBchr22

39626088

-DGCR2chr22

19055737

-
5CDS-intronENST00000331163ENST00000473832PDGFBchr22

39626088

-DGCR2chr22

19077002

-
5CDS-intronENST00000331163ENST00000473832PDGFBchr22

39626089

-DGCR2chr22

19077003

-
5CDS-intronENST00000331163ENST00000473832PDGFBchr22

39626088

-DGCR2chr22

19055738

-
5CDS-intronENST00000331163ENST00000473832PDGFBchr22

39626088

-DGCR2chr22

19077003

-
5CDS-intronENST00000331163ENST00000537045PDGFBchr22

39626088

-DGCR2chr22

19077002

-
5CDS-intronENST00000331163ENST00000537045PDGFBchr22

39626089

-DGCR2chr22

19077003

-
5CDS-intronENST00000331163ENST00000537045PDGFBchr22

39626088

-DGCR2chr22

19077003

-
5CDS-intronENST00000331163ENST00000545799PDGFBchr22

39626088

-DGCR2chr22

19077002

-
5CDS-intronENST00000331163ENST00000545799PDGFBchr22

39626089

-DGCR2chr22

19077003

-
5CDS-intronENST00000331163ENST00000545799PDGFBchr22

39626088

-DGCR2chr22

19077003

-
5CDS-intronENST00000381551ENST00000263196PDGFBchr22

39626088

-DGCR2chr22

19077002

-
5CDS-intronENST00000381551ENST00000263196PDGFBchr22

39626089

-DGCR2chr22

19077003

-
5CDS-intronENST00000381551ENST00000263196PDGFBchr22

39626088

-DGCR2chr22

19077003

-
5CDS-intronENST00000381551ENST00000473832PDGFBchr22

39626088

-DGCR2chr22

19055737

-
5CDS-intronENST00000381551ENST00000473832PDGFBchr22

39626088

-DGCR2chr22

19077002

-
5CDS-intronENST00000381551ENST00000473832PDGFBchr22

39626089

-DGCR2chr22

19077003

-
5CDS-intronENST00000381551ENST00000473832PDGFBchr22

39626088

-DGCR2chr22

19055738

-
5CDS-intronENST00000381551ENST00000473832PDGFBchr22

39626088

-DGCR2chr22

19077003

-
5CDS-intronENST00000381551ENST00000537045PDGFBchr22

39626088

-DGCR2chr22

19077002

-
5CDS-intronENST00000381551ENST00000537045PDGFBchr22

39626089

-DGCR2chr22

19077003

-
5CDS-intronENST00000381551ENST00000537045PDGFBchr22

39626088

-DGCR2chr22

19077003

-
5CDS-intronENST00000381551ENST00000545799PDGFBchr22

39626088

-DGCR2chr22

19077002

-
5CDS-intronENST00000381551ENST00000545799PDGFBchr22

39626089

-DGCR2chr22

19077003

-
5CDS-intronENST00000381551ENST00000545799PDGFBchr22

39626088

-DGCR2chr22

19077003

-
Frame-shiftENST00000331163ENST00000263196PDGFBchr22

39626088

-DGCR2chr22

19055737

-
Frame-shiftENST00000331163ENST00000263196PDGFBchr22

39626088

-DGCR2chr22

19055738

-
Frame-shiftENST00000331163ENST00000537045PDGFBchr22

39626088

-DGCR2chr22

19055737

-
Frame-shiftENST00000331163ENST00000537045PDGFBchr22

39626088

-DGCR2chr22

19055738

-
Frame-shiftENST00000381551ENST00000263196PDGFBchr22

39626088

-DGCR2chr22

19055737

-
Frame-shiftENST00000381551ENST00000263196PDGFBchr22

39626088

-DGCR2chr22

19055738

-
Frame-shiftENST00000381551ENST00000537045PDGFBchr22

39626088

-DGCR2chr22

19055737

-
Frame-shiftENST00000381551ENST00000537045PDGFBchr22

39626088

-DGCR2chr22

19055738

-
In-frameENST00000331163ENST00000545799PDGFBchr22

39626088

-DGCR2chr22

19055737

-
In-frameENST00000331163ENST00000545799PDGFBchr22

39626088

-DGCR2chr22

19055738

-
In-frameENST00000381551ENST00000545799PDGFBchr22

39626088

-DGCR2chr22

19055737

-
In-frameENST00000381551ENST00000545799PDGFBchr22

39626088

-DGCR2chr22

19055738

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000331163PDGFBchr2239626088-ENST00000545799DGCR2chr2219055738-579813891831473452
ENST00000381551PDGFBchr2239626088-ENST00000545799DGCR2chr2219055738-5002593191200393
ENST00000331163PDGFBchr2239626088-ENST00000545799DGCR2chr2219055737-579813891831473452
ENST00000381551PDGFBchr2239626088-ENST00000545799DGCR2chr2219055737-5002593191200393

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000331163ENST00000545799PDGFBchr2239626088-DGCR2chr2219055738-0.143095760.8569042
ENST00000381551ENST00000545799PDGFBchr2239626088-DGCR2chr2219055738-0.149719630.8502804
ENST00000331163ENST00000545799PDGFBchr2239626088-DGCR2chr2219055737-0.143095760.8569042
ENST00000381551ENST00000545799PDGFBchr2239626088-DGCR2chr2219055737-0.149719630.8502804

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Fusion Genomic Features for PDGFB-DGCR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDGFB-DGCR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:39626089/chr22:19077003)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DGCR2

P98153

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDGCR2chr22:39626088chr22:19055737ENST00000263196110115_24167551.0DomainC-type lectin
TgeneDGCR2chr22:39626088chr22:19055737ENST00000263196110270_33367551.0DomainNote=VWFC
TgeneDGCR2chr22:39626088chr22:19055737ENST0000053704509115_24126510.0DomainC-type lectin
TgeneDGCR2chr22:39626088chr22:19055737ENST0000053704509270_33326510.0DomainNote=VWFC
TgeneDGCR2chr22:39626088chr22:19055737ENST000005370450928_6826510.0DomainLDL-receptor class A
TgeneDGCR2chr22:39626088chr22:19055738ENST00000263196110115_24167551.0DomainC-type lectin
TgeneDGCR2chr22:39626088chr22:19055738ENST00000263196110270_33367551.0DomainNote=VWFC
TgeneDGCR2chr22:39626088chr22:19055738ENST0000053704509115_24126510.0DomainC-type lectin
TgeneDGCR2chr22:39626088chr22:19055738ENST0000053704509270_33326510.0DomainNote=VWFC
TgeneDGCR2chr22:39626088chr22:19055738ENST000005370450928_6826510.0DomainLDL-receptor class A
TgeneDGCR2chr22:39626088chr22:19055737ENST00000263196110369_55067551.0Topological domainCytoplasmic
TgeneDGCR2chr22:39626088chr22:19055737ENST0000053704509369_55026510.0Topological domainCytoplasmic
TgeneDGCR2chr22:39626088chr22:19055738ENST00000263196110369_55067551.0Topological domainCytoplasmic
TgeneDGCR2chr22:39626088chr22:19055738ENST0000053704509369_55026510.0Topological domainCytoplasmic
TgeneDGCR2chr22:39626088chr22:19055737ENST00000263196110350_36867551.0TransmembraneHelical
TgeneDGCR2chr22:39626088chr22:19055737ENST0000053704509350_36826510.0TransmembraneHelical
TgeneDGCR2chr22:39626088chr22:19055738ENST00000263196110350_36867551.0TransmembraneHelical
TgeneDGCR2chr22:39626088chr22:19055738ENST0000053704509350_36826510.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDGCR2chr22:39626088chr22:19055737ENST0000026319611028_6867551.0DomainLDL-receptor class A
TgeneDGCR2chr22:39626088chr22:19055738ENST0000026319611028_6867551.0DomainLDL-receptor class A
TgeneDGCR2chr22:39626088chr22:19055737ENST0000026319611021_34967551.0Topological domainExtracellular
TgeneDGCR2chr22:39626088chr22:19055737ENST000005370450921_34926510.0Topological domainExtracellular
TgeneDGCR2chr22:39626088chr22:19055738ENST0000026319611021_34967551.0Topological domainExtracellular
TgeneDGCR2chr22:39626088chr22:19055738ENST000005370450921_34926510.0Topological domainExtracellular


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Fusion Gene Sequence for PDGFB-DGCR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63834_63834_1_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000331163_DGCR2_chr22_19055737_ENST00000545799_length(transcript)=5798nt_BP=1389nt
GCAGCTCGCAGCTCGCAGCCCGCAGCCCGCAGAGGACGCCCAGAGCGGCGAGCGGGCGGGCAGACGGACCGACGGACTCGCGCCGCGTCC
ACCTGTCGGCCGGGCCCAGCCGAGCGCGCAGCGGGCACGCCGCGCGCGCGGAGCAGCCGTGCCCGCCGCCCGGGCCCCGCGCCAGGGCGC
ACACGCTCCCGCCCCCCTACCCGGCCCGGGCGGGAGTTTGCACCTCTCCCTGCCCGGGTGCTCGAGCTGCCGTTGCAAAGCCAACTTTGG
AAAAAGTTTTTTGGGGGAGACTTGGGCCTTGAGGTGCCCAGCTCCGCGCTTTCCGATTTTGGGGGCCTTTCCAGAAAATGTTGCAAAAAA
GCTAAGCCGGCGGGCAGAGGAAAACGCCTGTAGCCGGCGAGTGAAGACGAACCATCGACTGCCGTGTTCCTTTTCCTCTTGGAGGTTGGA
GTCCCCTGGGCGCCCCCACACGGCTAGACGCCTCGGCTGGTTCGCGACGCAGCCCCCCGGCCGTGGATGCTCACTCGGGCTCGGGATCCG
CCCAGGTAGCGGCCTCGGACCCAGGTCCTGCGCCCAGGTCCTCCCCTGCCCCCCAGCGACGGAGCCGGGGCCGGGGGCGGCGGCGCCCGG
GGGCCATGCGGGTGAGCCGCGGCTGCAGAGGCCTGAGCGCCTGATCGCCGCGGACCCGAGCCGAGCCCACCCCCCTCCCCAGCCCCCCAC
CCTGGCCGCGGGGGCGGCGCGCTCGATCTACGCGTCCGGGGCCCCGCGGGGCCGGGCCCGGAGTCGGCATGAATCGCTGCTGGGCGCTCT
TCCTGTCTCTCTGCTGCTACCTGCGTCTGGTCAGCGCCGAGGGGGACCCCATTCCCGAGGAGCTTTATGAGATGCTGAGTGACCACTCGA
TCCGCTCCTTTGATGATCTCCAACGCCTGCTGCACGGAGACCCCGGAGAGGAAGATGGGGCCGAGTTGGACCTGAACATGACCCGCTCCC
ACTCTGGAGGCGAGCTGGAGAGCTTGGCTCGTGGAAGAAGGAGCCTGGGTTCCCTGACCATTGCTGAGCCGGCCATGATCGCCGAGTGCA
AGACGCGCACCGAGGTGTTCGAGATCTCCCGGCGCCTCATAGACCGCACCAACGCCAACTTCCTGGTGTGGCCGCCCTGTGTGGAGGTGC
AGCGCTGCTCCGGCTGCTGCAACAACCGCAACGTGCAGTGCCGCCCCACCCAGGTGCAGCTGCGACCTGTCCAGGTGAGAAAGATCGAGA
TTGTGCGGAAGAAGCCAATCTTTAAGAAGGCCACGGTGACGCTGGAAGACCACCTGGCATGCAAGTGTGAGACAGTGGCAGCTGCACGGC
CTGTGACCCGAAGCCCGGGGGGTTCCCAGGAGCAGCGAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGATCCGC
GGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGGAAGTGCCCGACAG
GGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAGCGCC
TGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTTGGTT
GGAAGGACCAGCGCAAGTTGTGGGTTGGCTATCAGTATGTTATCACTGGCCGGAACCGCTCCTTGGAAGGTCGCTGGGAGGTGGCATTCA
AAGATTGGGGTGTGAGTGATACCATGGTACATAGACGCTTACTATGCCCATGTGTCGGTACCCTGCACACACATTTGAAGTTGGGAGCTC
GTTTCCGCAGGGTTCCTGTGCGCCTTGGTGGAGCGCTCTCCAGGCGCTCCCCCAGGCCCACACCAGCCTGTGAGCCCCGCCTGGGGGCCA
AGACCCTGCAGGTTTGACAGCACCAGGTCATGATGTGCCCTGGAGACAGAACTGCCGCTGCTGCTGCCAGAAGACATGAGGCCAGGATTT
CTGTAACATTTGTGCAGAAAGGTTGAAAAAGTACAGATCCTTGTGTAGGGAGAATCATCCACACCGCCCCACGTGCTGCTCCCAGGGCCT
TCCCGTCAGCACCAGCAGTGTAGCTTCTGTCTGGCTCTTCAGAGGTGTTCCTGCCCCCAGACCCCATCTTTGCCTCGGCCATGTCTGAGA
ACGACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACGACCTCCACAGCTGGCACGCCGAGAGCTGCT
ACGAGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACGTGGTGGATGAAGGGTTCTACTTCACCCCTA
AGGGGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGGCTGCTCTCTGTGAGAGGCCCCAGGGCTGCC
AACAGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCAACAGTCTGTTTGACTCCATGGCCAGCGGGA
TGCGCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGGTCCACCGGCTGCGCCAGCGGCGCCGGGAGC
GCATCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTGGCTTTGATTACGGCCCAGACGGGTTTGGCA
CGGGCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACGACCCTCCACCTCCCTACACGGCATACAAGT
ACCCGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGGACAGTGTGTTCTATGACCCTGCAGACGATG
ATGCTTTTGAGCCTGTGGAGGTCAGCCTGCCAGCCCCTGGGGATGGTGGGAGTGAAGGTGCATTACTCCGGCGCCTGGAGCAGCCTCTGC
CCACTGCGGGGGCCTCTCTGGCAGACCTGGAAGACTCTGCCGACAGCAGCAGCGCCCTGCTCGTGCCCCCTGACCCTGCCCAGAGCGGGA
GCACCCCAGCTGCAGAGGCACTGCCAGGGGGTGGCCGCCACAGCCGCAGCTCCCTCAATACTGTGGTGTAGACGGCCTGGCCTGTACCCC
AACGGTCTGGGAGCACCTGTCTGTTGTAGAAAACACCGGTCCCTGGGGAGACTTGAAAGGCCCCTGTCCCAGCCTGGACGCCACGCACTG
CCGCACGTCACTGGCGGGCTCGCGTGTGTACATAGAGACCACAGCCCGCCTTCTGCCAAAAGAAGTGATGGCCTGCACCGAGCTTCCTTG
AGGGCTTCAGAAACATGCATAGCTTTGGATCACTGTCTTCTCCTTTATAAATGGCAGAAGAGTGACAAAATTCATTCAGACCGCACATGT
TAGAGGCAGGGAATGAAGAAGGTACTGTGGGCCATGGCCACACCTGATGCGTTTTTGGTGGGCTTACTTGGTGCAGTGTGCTGTCCAGAG
AGACCTGCTGACCCAGTCTGGGACAGGCACAGTGGGAGCTGCCACAGTGCCCCTTGCTGGCCGCCCTCAGGAGGGGGCCTCTGGACCGTC
AGTGTGGCGTAGGCAGTGGGTCTGCTTCAGGGAGGCAGCCTCTTGACTTTGTCACAACGGTTGCACTGAAGATGGCCCCCACAAGCCCAG
TTGTGAATATCAAGGTGACCCTGCCCCTGGCTGGGAGCTCCCCTGGGGCTCTGGAACCTGAAGCCCTGAGAAGGAGAGCTTGGAAGGAGG
TTGAGCTCTTCACTGTGTCTTTCCATCTGGGCTCTGCAGCCCAGCTCTGTGGCAGGAGGCCTGACCCCACCCCATCAGTCCCTCTCCCAG
CATTGCTGTGCATGGCTCCCTCAGGAAGAAGCTCTGGAGTGGGGCCGAGGCCCCAGATGCTCTGCTGGGGTCTGGGGACTGAGCTGCCTC
CTGTCTCTCCACTCTGGAGCCCTGGGCTCTTGCCTCCTGTTGAATTGCCCCTGGGCCTGCCCCCGGCCCCATTTGTGCCATAAAGGGTTG
CTTCATTGCAGGAGGGGTGGCTGAAACCACCATCCTGGGCTGCATCTATCTCCTTAAAGTCCACTCCTTACATCACCGCCACTACTGCAG
CTCAGTGCCCAGCGGCCGCATGCACACCTCCCGGCCCCTCCTCAGCAGCGCAGGGGCTGGGGGCCCTTCCTGGCACCCTTTTGCCTGACG
GACCCTGTTGCCTGCTCCTGGGCAGTGGTTTTGTTGCCTGACACAGGGCCTTTAACATTTCTGAGGTTTGGAGATTAAGCGGGTTCTGTG
CGATTTTTAGCACATCCATATCTTTTCTACGTTGAATGTCTGGATCTTTCCTTTGTATGTTTGTGTCTCTGTGTGTGTATGTGGCCAAGC
GTCTGCAGGTGAGGGTGGCACATGGAACTTCACGGGTCACTGGGGGCCCACTCTTCCAGGGTCATCGATGCATCCTGGGCTGTGCTGAGG
CAGTGCTGTCTCGCTCAGTCTTTCCAGACCAGCGGGGCAGCACCTGGGAGGCCTGTCTGAAGCATGCAGTTCTGTGGTGCTGCTCGGGGA
TGGACTCCATGCACAGTCCACTTCTTGACACATTCTCACACTGTGGCTGGAGACCCATTTTTTCCATCCCATGTGGAATGAGAATCTTGA
GTTGCCCACAGACAGACTTGACCTTTGTGCCAGAACTGTCCAGAGCTGTGAGTTTTGTTACTGAATTGCCTGTCCCTGAGCTTGGCCTGC
TGGAGCATGATGCTGGAGGCTGTGTGCGGGCAGGCTTGTGCTCCCCTTGGAGAAGGGCTGCTACTTAACAAGGAAGTCCTGGCCACAGGA
GTCCCCTACTGGCTGCAGAGGACGAAGCAGGAAGCATGCCGTGGATCCCACATGCACTGGGGCAGGGCAGCCAGGTTCCAGAGCAGCAGG
CATGTGCATTATGGGTGCCAGGTGGCCAGTGAGGGCCCGAGGACCACGCAGCAGAGTCCCCCACGGGCCTGAGCCTGAGAGCTCAGAGGA
TTCCTGCCAGGCCTCAGAACTGTGTGTGCGGGACAGGGTGGCTGGCACGAGATGTGTGGGACTGGGACGCTTCCTTTGGGGACCAGAGGA
ACATTAGGGGCCGGTCAGACACGTAGGGGGCAGTGAGGAAACGGGGTAAAGTGGACCATGCAGGCTGCAGAGGGTGGGCCTTGGGCTGGC
CGGGGTTGCTGGGTGGCCCCTTCCCCATGGGCCTCCACAAGCACTCAGGCCACTGGCACGTTGGGCCAGGCAGAAGGTCCACATGGCAGG
GCTGCCTGGAACACCGCTGCCACTGTGGCTCCAGGAGGCCCTTGGGAGCATGAGGAGAGCTGGACTCGCTCATCTGTTCTTGCACCACCA
TCCAGAATGCCCCCTTTGCAAGGCCTGCTGCAGTCCCCAGTCTGACCAGCAAGTCCCGGGGTCACCCTTGCTGAACCTTGTGCTCCAGGG
GTCCTCCTCCTCTAGGACCAGCTTGCCACGGTTTCTCAGAGCCCAGGTGCCCTCTGACCTGCCATGCGGAGGTGGGATTTGATACTGTAC
ATTGTCTTGATGCCTGTTTTTTTATGTTTTCATTAAGGGTTTTTAGTTTTTGGTTGGGTTGACACTAACTTTTCTTAAGATGCTGTGAGA

>63834_63834_1_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000331163_DGCR2_chr22_19055737_ENST00000545799_length(amino acids)=452AA_BP=0
MYHGITHTPIFECHLPATFQGAVPASDNILIANPQLALVLPTKAPLGLVPFLGQDKAQLLVSGEGGERAIQALAGLRGIPVVLPAQVDPV
AAGRAFVVVPPCRALPAEANGLRHVHRVEVRRVASSGPPLPRIHSLLPMMRTHLPGHFSLLLGTPRASGHRPCSCHCLTLACQVVFQRHR
GLLKDWLLPHNLDLSHLDRSQLHLGGAALHVAVVAAAGAALHLHTGRPHQEVGVGAVYEAPGDLEHLGARLALGDHGRLSNGQGTQAPSS
TSQALQLASRVGAGHVQVQLGPIFLSGVSVQQALEIIKGADRVVTQHLIKLLGNGVPLGADQTQVAAERQEERPAAIHADSGPGPAGPRT
RRSSAPPPRPGWGAGEGGGLGSGPRRSGAQASAAAAHPHGPRAPPPPAPAPSLGGRGGPGRRTWVRGRYLGGSRARVSIHGRGAASRTSR

--------------------------------------------------------------
>63834_63834_2_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000331163_DGCR2_chr22_19055738_ENST00000545799_length(transcript)=5798nt_BP=1389nt
GCAGCTCGCAGCTCGCAGCCCGCAGCCCGCAGAGGACGCCCAGAGCGGCGAGCGGGCGGGCAGACGGACCGACGGACTCGCGCCGCGTCC
ACCTGTCGGCCGGGCCCAGCCGAGCGCGCAGCGGGCACGCCGCGCGCGCGGAGCAGCCGTGCCCGCCGCCCGGGCCCCGCGCCAGGGCGC
ACACGCTCCCGCCCCCCTACCCGGCCCGGGCGGGAGTTTGCACCTCTCCCTGCCCGGGTGCTCGAGCTGCCGTTGCAAAGCCAACTTTGG
AAAAAGTTTTTTGGGGGAGACTTGGGCCTTGAGGTGCCCAGCTCCGCGCTTTCCGATTTTGGGGGCCTTTCCAGAAAATGTTGCAAAAAA
GCTAAGCCGGCGGGCAGAGGAAAACGCCTGTAGCCGGCGAGTGAAGACGAACCATCGACTGCCGTGTTCCTTTTCCTCTTGGAGGTTGGA
GTCCCCTGGGCGCCCCCACACGGCTAGACGCCTCGGCTGGTTCGCGACGCAGCCCCCCGGCCGTGGATGCTCACTCGGGCTCGGGATCCG
CCCAGGTAGCGGCCTCGGACCCAGGTCCTGCGCCCAGGTCCTCCCCTGCCCCCCAGCGACGGAGCCGGGGCCGGGGGCGGCGGCGCCCGG
GGGCCATGCGGGTGAGCCGCGGCTGCAGAGGCCTGAGCGCCTGATCGCCGCGGACCCGAGCCGAGCCCACCCCCCTCCCCAGCCCCCCAC
CCTGGCCGCGGGGGCGGCGCGCTCGATCTACGCGTCCGGGGCCCCGCGGGGCCGGGCCCGGAGTCGGCATGAATCGCTGCTGGGCGCTCT
TCCTGTCTCTCTGCTGCTACCTGCGTCTGGTCAGCGCCGAGGGGGACCCCATTCCCGAGGAGCTTTATGAGATGCTGAGTGACCACTCGA
TCCGCTCCTTTGATGATCTCCAACGCCTGCTGCACGGAGACCCCGGAGAGGAAGATGGGGCCGAGTTGGACCTGAACATGACCCGCTCCC
ACTCTGGAGGCGAGCTGGAGAGCTTGGCTCGTGGAAGAAGGAGCCTGGGTTCCCTGACCATTGCTGAGCCGGCCATGATCGCCGAGTGCA
AGACGCGCACCGAGGTGTTCGAGATCTCCCGGCGCCTCATAGACCGCACCAACGCCAACTTCCTGGTGTGGCCGCCCTGTGTGGAGGTGC
AGCGCTGCTCCGGCTGCTGCAACAACCGCAACGTGCAGTGCCGCCCCACCCAGGTGCAGCTGCGACCTGTCCAGGTGAGAAAGATCGAGA
TTGTGCGGAAGAAGCCAATCTTTAAGAAGGCCACGGTGACGCTGGAAGACCACCTGGCATGCAAGTGTGAGACAGTGGCAGCTGCACGGC
CTGTGACCCGAAGCCCGGGGGGTTCCCAGGAGCAGCGAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGATCCGC
GGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGGAAGTGCCCGACAG
GGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAGCGCC
TGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTTGGTT
GGAAGGACCAGCGCAAGTTGTGGGTTGGCTATCAGTATGTTATCACTGGCCGGAACCGCTCCTTGGAAGGTCGCTGGGAGGTGGCATTCA
AAGATTGGGGTGTGAGTGATACCATGGTACATAGACGCTTACTATGCCCATGTGTCGGTACCCTGCACACACATTTGAAGTTGGGAGCTC
GTTTCCGCAGGGTTCCTGTGCGCCTTGGTGGAGCGCTCTCCAGGCGCTCCCCCAGGCCCACACCAGCCTGTGAGCCCCGCCTGGGGGCCA
AGACCCTGCAGGTTTGACAGCACCAGGTCATGATGTGCCCTGGAGACAGAACTGCCGCTGCTGCTGCCAGAAGACATGAGGCCAGGATTT
CTGTAACATTTGTGCAGAAAGGTTGAAAAAGTACAGATCCTTGTGTAGGGAGAATCATCCACACCGCCCCACGTGCTGCTCCCAGGGCCT
TCCCGTCAGCACCAGCAGTGTAGCTTCTGTCTGGCTCTTCAGAGGTGTTCCTGCCCCCAGACCCCATCTTTGCCTCGGCCATGTCTGAGA
ACGACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACGACCTCCACAGCTGGCACGCCGAGAGCTGCT
ACGAGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACGTGGTGGATGAAGGGTTCTACTTCACCCCTA
AGGGGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGGCTGCTCTCTGTGAGAGGCCCCAGGGCTGCC
AACAGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCAACAGTCTGTTTGACTCCATGGCCAGCGGGA
TGCGCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGGTCCACCGGCTGCGCCAGCGGCGCCGGGAGC
GCATCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTGGCTTTGATTACGGCCCAGACGGGTTTGGCA
CGGGCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACGACCCTCCACCTCCCTACACGGCATACAAGT
ACCCGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGGACAGTGTGTTCTATGACCCTGCAGACGATG
ATGCTTTTGAGCCTGTGGAGGTCAGCCTGCCAGCCCCTGGGGATGGTGGGAGTGAAGGTGCATTACTCCGGCGCCTGGAGCAGCCTCTGC
CCACTGCGGGGGCCTCTCTGGCAGACCTGGAAGACTCTGCCGACAGCAGCAGCGCCCTGCTCGTGCCCCCTGACCCTGCCCAGAGCGGGA
GCACCCCAGCTGCAGAGGCACTGCCAGGGGGTGGCCGCCACAGCCGCAGCTCCCTCAATACTGTGGTGTAGACGGCCTGGCCTGTACCCC
AACGGTCTGGGAGCACCTGTCTGTTGTAGAAAACACCGGTCCCTGGGGAGACTTGAAAGGCCCCTGTCCCAGCCTGGACGCCACGCACTG
CCGCACGTCACTGGCGGGCTCGCGTGTGTACATAGAGACCACAGCCCGCCTTCTGCCAAAAGAAGTGATGGCCTGCACCGAGCTTCCTTG
AGGGCTTCAGAAACATGCATAGCTTTGGATCACTGTCTTCTCCTTTATAAATGGCAGAAGAGTGACAAAATTCATTCAGACCGCACATGT
TAGAGGCAGGGAATGAAGAAGGTACTGTGGGCCATGGCCACACCTGATGCGTTTTTGGTGGGCTTACTTGGTGCAGTGTGCTGTCCAGAG
AGACCTGCTGACCCAGTCTGGGACAGGCACAGTGGGAGCTGCCACAGTGCCCCTTGCTGGCCGCCCTCAGGAGGGGGCCTCTGGACCGTC
AGTGTGGCGTAGGCAGTGGGTCTGCTTCAGGGAGGCAGCCTCTTGACTTTGTCACAACGGTTGCACTGAAGATGGCCCCCACAAGCCCAG
TTGTGAATATCAAGGTGACCCTGCCCCTGGCTGGGAGCTCCCCTGGGGCTCTGGAACCTGAAGCCCTGAGAAGGAGAGCTTGGAAGGAGG
TTGAGCTCTTCACTGTGTCTTTCCATCTGGGCTCTGCAGCCCAGCTCTGTGGCAGGAGGCCTGACCCCACCCCATCAGTCCCTCTCCCAG
CATTGCTGTGCATGGCTCCCTCAGGAAGAAGCTCTGGAGTGGGGCCGAGGCCCCAGATGCTCTGCTGGGGTCTGGGGACTGAGCTGCCTC
CTGTCTCTCCACTCTGGAGCCCTGGGCTCTTGCCTCCTGTTGAATTGCCCCTGGGCCTGCCCCCGGCCCCATTTGTGCCATAAAGGGTTG
CTTCATTGCAGGAGGGGTGGCTGAAACCACCATCCTGGGCTGCATCTATCTCCTTAAAGTCCACTCCTTACATCACCGCCACTACTGCAG
CTCAGTGCCCAGCGGCCGCATGCACACCTCCCGGCCCCTCCTCAGCAGCGCAGGGGCTGGGGGCCCTTCCTGGCACCCTTTTGCCTGACG
GACCCTGTTGCCTGCTCCTGGGCAGTGGTTTTGTTGCCTGACACAGGGCCTTTAACATTTCTGAGGTTTGGAGATTAAGCGGGTTCTGTG
CGATTTTTAGCACATCCATATCTTTTCTACGTTGAATGTCTGGATCTTTCCTTTGTATGTTTGTGTCTCTGTGTGTGTATGTGGCCAAGC
GTCTGCAGGTGAGGGTGGCACATGGAACTTCACGGGTCACTGGGGGCCCACTCTTCCAGGGTCATCGATGCATCCTGGGCTGTGCTGAGG
CAGTGCTGTCTCGCTCAGTCTTTCCAGACCAGCGGGGCAGCACCTGGGAGGCCTGTCTGAAGCATGCAGTTCTGTGGTGCTGCTCGGGGA
TGGACTCCATGCACAGTCCACTTCTTGACACATTCTCACACTGTGGCTGGAGACCCATTTTTTCCATCCCATGTGGAATGAGAATCTTGA
GTTGCCCACAGACAGACTTGACCTTTGTGCCAGAACTGTCCAGAGCTGTGAGTTTTGTTACTGAATTGCCTGTCCCTGAGCTTGGCCTGC
TGGAGCATGATGCTGGAGGCTGTGTGCGGGCAGGCTTGTGCTCCCCTTGGAGAAGGGCTGCTACTTAACAAGGAAGTCCTGGCCACAGGA
GTCCCCTACTGGCTGCAGAGGACGAAGCAGGAAGCATGCCGTGGATCCCACATGCACTGGGGCAGGGCAGCCAGGTTCCAGAGCAGCAGG
CATGTGCATTATGGGTGCCAGGTGGCCAGTGAGGGCCCGAGGACCACGCAGCAGAGTCCCCCACGGGCCTGAGCCTGAGAGCTCAGAGGA
TTCCTGCCAGGCCTCAGAACTGTGTGTGCGGGACAGGGTGGCTGGCACGAGATGTGTGGGACTGGGACGCTTCCTTTGGGGACCAGAGGA
ACATTAGGGGCCGGTCAGACACGTAGGGGGCAGTGAGGAAACGGGGTAAAGTGGACCATGCAGGCTGCAGAGGGTGGGCCTTGGGCTGGC
CGGGGTTGCTGGGTGGCCCCTTCCCCATGGGCCTCCACAAGCACTCAGGCCACTGGCACGTTGGGCCAGGCAGAAGGTCCACATGGCAGG
GCTGCCTGGAACACCGCTGCCACTGTGGCTCCAGGAGGCCCTTGGGAGCATGAGGAGAGCTGGACTCGCTCATCTGTTCTTGCACCACCA
TCCAGAATGCCCCCTTTGCAAGGCCTGCTGCAGTCCCCAGTCTGACCAGCAAGTCCCGGGGTCACCCTTGCTGAACCTTGTGCTCCAGGG
GTCCTCCTCCTCTAGGACCAGCTTGCCACGGTTTCTCAGAGCCCAGGTGCCCTCTGACCTGCCATGCGGAGGTGGGATTTGATACTGTAC
ATTGTCTTGATGCCTGTTTTTTTATGTTTTCATTAAGGGTTTTTAGTTTTTGGTTGGGTTGACACTAACTTTTCTTAAGATGCTGTGAGA

>63834_63834_2_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000331163_DGCR2_chr22_19055738_ENST00000545799_length(amino acids)=452AA_BP=0
MYHGITHTPIFECHLPATFQGAVPASDNILIANPQLALVLPTKAPLGLVPFLGQDKAQLLVSGEGGERAIQALAGLRGIPVVLPAQVDPV
AAGRAFVVVPPCRALPAEANGLRHVHRVEVRRVASSGPPLPRIHSLLPMMRTHLPGHFSLLLGTPRASGHRPCSCHCLTLACQVVFQRHR
GLLKDWLLPHNLDLSHLDRSQLHLGGAALHVAVVAAAGAALHLHTGRPHQEVGVGAVYEAPGDLEHLGARLALGDHGRLSNGQGTQAPSS
TSQALQLASRVGAGHVQVQLGPIFLSGVSVQQALEIIKGADRVVTQHLIKLLGNGVPLGADQTQVAAERQEERPAAIHADSGPGPAGPRT
RRSSAPPPRPGWGAGEGGGLGSGPRRSGAQASAAAAHPHGPRAPPPPAPAPSLGGRGGPGRRTWVRGRYLGGSRARVSIHGRGAASRTSR

--------------------------------------------------------------
>63834_63834_3_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000381551_DGCR2_chr22_19055737_ENST00000545799_length(transcript)=5002nt_BP=593nt
AGAGAGAGAGAGAGACTGACTGAGCAGGAATGGTGAGATGTTTATCATGGGCCTCGGGGACCCCATTCCCGAGGAGCTTTATGAGATGCT
GAGTGACCACTCGATCCGCTCCTTTGATGATCTCCAACGCCTGCTGCACGGAGACCCCGGAGAGGAAGATGGGGCCGAGTTGGACCTGAA
CATGACCCGCTCCCACTCTGGAGGCGAGCTGGAGAGCTTGGCTCGTGGAAGAAGGAGCCTGGGTTCCCTGACCATTGCTGAGCCGGCCAT
GATCGCCGAGTGCAAGACGCGCACCGAGGTGTTCGAGATCTCCCGGCGCCTCATAGACCGCACCAACGCCAACTTCCTGGTGTGGCCGCC
CTGTGTGGAGGTGCAGCGCTGCTCCGGCTGCTGCAACAACCGCAACGTGCAGTGCCGCCCCACCCAGGTGCAGCTGCGACCTGTCCAGGT
GAGAAAGATCGAGATTGTGCGGAAGAAGCCAATCTTTAAGAAGGCCACGGTGACGCTGGAAGACCACCTGGCATGCAAGTGTGAGACAGT
GGCAGCTGCACGGCCTGTGACCCGAAGCCCGGGGGGTTCCCAGGAGCAGCGAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGA
GGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAG
GAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCA
GACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGA
GCGGAGCTTTGGTTGGAAGGACCAGCGCAAGTTGTGGGTTGGCTATCAGTATGTTATCACTGGCCGGAACCGCTCCTTGGAAGGTCGCTG
GGAGGTGGCATTCAAAGATTGGGGTGTGAGTGATACCATGGTACATAGACGCTTACTATGCCCATGTGTCGGTACCCTGCACACACATTT
GAAGTTGGGAGCTCGTTTCCGCAGGGTTCCTGTGCGCCTTGGTGGAGCGCTCTCCAGGCGCTCCCCCAGGCCCACACCAGCCTGTGAGCC
CCGCCTGGGGGCCAAGACCCTGCAGGTTTGACAGCACCAGGTCATGATGTGCCCTGGAGACAGAACTGCCGCTGCTGCTGCCAGAAGACA
TGAGGCCAGGATTTCTGTAACATTTGTGCAGAAAGGTTGAAAAAGTACAGATCCTTGTGTAGGGAGAATCATCCACACCGCCCCACGTGC
TGCTCCCAGGGCCTTCCCGTCAGCACCAGCAGTGTAGCTTCTGTCTGGCTCTTCAGAGGTGTTCCTGCCCCCAGACCCCATCTTTGCCTC
GGCCATGTCTGAGAACGACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACGACCTCCACAGCTGGCA
CGCCGAGAGCTGCTACGAGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACGTGGTGGATGAAGGGTT
CTACTTCACCCCTAAGGGGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGGCTGCTCTCTGTGAGAG
GCCCCAGGGCTGCCAACAGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCAACAGTCTGTTTGACTC
CATGGCCAGCGGGATGCGCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGGTCCACCGGCTGCGCCA
GCGGCGCCGGGAGCGCATCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTGGCTTTGATTACGGCCC
AGACGGGTTTGGCACGGGCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACGACCCTCCACCTCCCTA
CACGGCATACAAGTACCCGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGGACAGTGTGTTCTATGA
CCCTGCAGACGATGATGCTTTTGAGCCTGTGGAGGTCAGCCTGCCAGCCCCTGGGGATGGTGGGAGTGAAGGTGCATTACTCCGGCGCCT
GGAGCAGCCTCTGCCCACTGCGGGGGCCTCTCTGGCAGACCTGGAAGACTCTGCCGACAGCAGCAGCGCCCTGCTCGTGCCCCCTGACCC
TGCCCAGAGCGGGAGCACCCCAGCTGCAGAGGCACTGCCAGGGGGTGGCCGCCACAGCCGCAGCTCCCTCAATACTGTGGTGTAGACGGC
CTGGCCTGTACCCCAACGGTCTGGGAGCACCTGTCTGTTGTAGAAAACACCGGTCCCTGGGGAGACTTGAAAGGCCCCTGTCCCAGCCTG
GACGCCACGCACTGCCGCACGTCACTGGCGGGCTCGCGTGTGTACATAGAGACCACAGCCCGCCTTCTGCCAAAAGAAGTGATGGCCTGC
ACCGAGCTTCCTTGAGGGCTTCAGAAACATGCATAGCTTTGGATCACTGTCTTCTCCTTTATAAATGGCAGAAGAGTGACAAAATTCATT
CAGACCGCACATGTTAGAGGCAGGGAATGAAGAAGGTACTGTGGGCCATGGCCACACCTGATGCGTTTTTGGTGGGCTTACTTGGTGCAG
TGTGCTGTCCAGAGAGACCTGCTGACCCAGTCTGGGACAGGCACAGTGGGAGCTGCCACAGTGCCCCTTGCTGGCCGCCCTCAGGAGGGG
GCCTCTGGACCGTCAGTGTGGCGTAGGCAGTGGGTCTGCTTCAGGGAGGCAGCCTCTTGACTTTGTCACAACGGTTGCACTGAAGATGGC
CCCCACAAGCCCAGTTGTGAATATCAAGGTGACCCTGCCCCTGGCTGGGAGCTCCCCTGGGGCTCTGGAACCTGAAGCCCTGAGAAGGAG
AGCTTGGAAGGAGGTTGAGCTCTTCACTGTGTCTTTCCATCTGGGCTCTGCAGCCCAGCTCTGTGGCAGGAGGCCTGACCCCACCCCATC
AGTCCCTCTCCCAGCATTGCTGTGCATGGCTCCCTCAGGAAGAAGCTCTGGAGTGGGGCCGAGGCCCCAGATGCTCTGCTGGGGTCTGGG
GACTGAGCTGCCTCCTGTCTCTCCACTCTGGAGCCCTGGGCTCTTGCCTCCTGTTGAATTGCCCCTGGGCCTGCCCCCGGCCCCATTTGT
GCCATAAAGGGTTGCTTCATTGCAGGAGGGGTGGCTGAAACCACCATCCTGGGCTGCATCTATCTCCTTAAAGTCCACTCCTTACATCAC
CGCCACTACTGCAGCTCAGTGCCCAGCGGCCGCATGCACACCTCCCGGCCCCTCCTCAGCAGCGCAGGGGCTGGGGGCCCTTCCTGGCAC
CCTTTTGCCTGACGGACCCTGTTGCCTGCTCCTGGGCAGTGGTTTTGTTGCCTGACACAGGGCCTTTAACATTTCTGAGGTTTGGAGATT
AAGCGGGTTCTGTGCGATTTTTAGCACATCCATATCTTTTCTACGTTGAATGTCTGGATCTTTCCTTTGTATGTTTGTGTCTCTGTGTGT
GTATGTGGCCAAGCGTCTGCAGGTGAGGGTGGCACATGGAACTTCACGGGTCACTGGGGGCCCACTCTTCCAGGGTCATCGATGCATCCT
GGGCTGTGCTGAGGCAGTGCTGTCTCGCTCAGTCTTTCCAGACCAGCGGGGCAGCACCTGGGAGGCCTGTCTGAAGCATGCAGTTCTGTG
GTGCTGCTCGGGGATGGACTCCATGCACAGTCCACTTCTTGACACATTCTCACACTGTGGCTGGAGACCCATTTTTTCCATCCCATGTGG
AATGAGAATCTTGAGTTGCCCACAGACAGACTTGACCTTTGTGCCAGAACTGTCCAGAGCTGTGAGTTTTGTTACTGAATTGCCTGTCCC
TGAGCTTGGCCTGCTGGAGCATGATGCTGGAGGCTGTGTGCGGGCAGGCTTGTGCTCCCCTTGGAGAAGGGCTGCTACTTAACAAGGAAG
TCCTGGCCACAGGAGTCCCCTACTGGCTGCAGAGGACGAAGCAGGAAGCATGCCGTGGATCCCACATGCACTGGGGCAGGGCAGCCAGGT
TCCAGAGCAGCAGGCATGTGCATTATGGGTGCCAGGTGGCCAGTGAGGGCCCGAGGACCACGCAGCAGAGTCCCCCACGGGCCTGAGCCT
GAGAGCTCAGAGGATTCCTGCCAGGCCTCAGAACTGTGTGTGCGGGACAGGGTGGCTGGCACGAGATGTGTGGGACTGGGACGCTTCCTT
TGGGGACCAGAGGAACATTAGGGGCCGGTCAGACACGTAGGGGGCAGTGAGGAAACGGGGTAAAGTGGACCATGCAGGCTGCAGAGGGTG
GGCCTTGGGCTGGCCGGGGTTGCTGGGTGGCCCCTTCCCCATGGGCCTCCACAAGCACTCAGGCCACTGGCACGTTGGGCCAGGCAGAAG
GTCCACATGGCAGGGCTGCCTGGAACACCGCTGCCACTGTGGCTCCAGGAGGCCCTTGGGAGCATGAGGAGAGCTGGACTCGCTCATCTG
TTCTTGCACCACCATCCAGAATGCCCCCTTTGCAAGGCCTGCTGCAGTCCCCAGTCTGACCAGCAAGTCCCGGGGTCACCCTTGCTGAAC
CTTGTGCTCCAGGGGTCCTCCTCCTCTAGGACCAGCTTGCCACGGTTTCTCAGAGCCCAGGTGCCCTCTGACCTGCCATGCGGAGGTGGG
ATTTGATACTGTACATTGTCTTGATGCCTGTTTTTTTATGTTTTCATTAAGGGTTTTTAGTTTTTGGTTGGGTTGACACTAACTTTTCTT

>63834_63834_3_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000381551_DGCR2_chr22_19055737_ENST00000545799_length(amino acids)=393AA_BP=191
MSRNGEMFIMGLGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKT
RTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPV
TRSPGGSQEQREVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSRKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLN
GSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAFKDWGVSDTMVHRRLLCPCVGTLHTHLKLGARF

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>63834_63834_4_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000381551_DGCR2_chr22_19055738_ENST00000545799_length(transcript)=5002nt_BP=593nt
AGAGAGAGAGAGAGACTGACTGAGCAGGAATGGTGAGATGTTTATCATGGGCCTCGGGGACCCCATTCCCGAGGAGCTTTATGAGATGCT
GAGTGACCACTCGATCCGCTCCTTTGATGATCTCCAACGCCTGCTGCACGGAGACCCCGGAGAGGAAGATGGGGCCGAGTTGGACCTGAA
CATGACCCGCTCCCACTCTGGAGGCGAGCTGGAGAGCTTGGCTCGTGGAAGAAGGAGCCTGGGTTCCCTGACCATTGCTGAGCCGGCCAT
GATCGCCGAGTGCAAGACGCGCACCGAGGTGTTCGAGATCTCCCGGCGCCTCATAGACCGCACCAACGCCAACTTCCTGGTGTGGCCGCC
CTGTGTGGAGGTGCAGCGCTGCTCCGGCTGCTGCAACAACCGCAACGTGCAGTGCCGCCCCACCCAGGTGCAGCTGCGACCTGTCCAGGT
GAGAAAGATCGAGATTGTGCGGAAGAAGCCAATCTTTAAGAAGGCCACGGTGACGCTGGAAGACCACCTGGCATGCAAGTGTGAGACAGT
GGCAGCTGCACGGCCTGTGACCCGAAGCCCGGGGGGTTCCCAGGAGCAGCGAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGA
GGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAG
GAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCA
GACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGA
GCGGAGCTTTGGTTGGAAGGACCAGCGCAAGTTGTGGGTTGGCTATCAGTATGTTATCACTGGCCGGAACCGCTCCTTGGAAGGTCGCTG
GGAGGTGGCATTCAAAGATTGGGGTGTGAGTGATACCATGGTACATAGACGCTTACTATGCCCATGTGTCGGTACCCTGCACACACATTT
GAAGTTGGGAGCTCGTTTCCGCAGGGTTCCTGTGCGCCTTGGTGGAGCGCTCTCCAGGCGCTCCCCCAGGCCCACACCAGCCTGTGAGCC
CCGCCTGGGGGCCAAGACCCTGCAGGTTTGACAGCACCAGGTCATGATGTGCCCTGGAGACAGAACTGCCGCTGCTGCTGCCAGAAGACA
TGAGGCCAGGATTTCTGTAACATTTGTGCAGAAAGGTTGAAAAAGTACAGATCCTTGTGTAGGGAGAATCATCCACACCGCCCCACGTGC
TGCTCCCAGGGCCTTCCCGTCAGCACCAGCAGTGTAGCTTCTGTCTGGCTCTTCAGAGGTGTTCCTGCCCCCAGACCCCATCTTTGCCTC
GGCCATGTCTGAGAACGACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACGACCTCCACAGCTGGCA
CGCCGAGAGCTGCTACGAGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACGTGGTGGATGAAGGGTT
CTACTTCACCCCTAAGGGGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGGCTGCTCTCTGTGAGAG
GCCCCAGGGCTGCCAACAGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCAACAGTCTGTTTGACTC
CATGGCCAGCGGGATGCGCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGGTCCACCGGCTGCGCCA
GCGGCGCCGGGAGCGCATCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTGGCTTTGATTACGGCCC
AGACGGGTTTGGCACGGGCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACGACCCTCCACCTCCCTA
CACGGCATACAAGTACCCGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGGACAGTGTGTTCTATGA
CCCTGCAGACGATGATGCTTTTGAGCCTGTGGAGGTCAGCCTGCCAGCCCCTGGGGATGGTGGGAGTGAAGGTGCATTACTCCGGCGCCT
GGAGCAGCCTCTGCCCACTGCGGGGGCCTCTCTGGCAGACCTGGAAGACTCTGCCGACAGCAGCAGCGCCCTGCTCGTGCCCCCTGACCC
TGCCCAGAGCGGGAGCACCCCAGCTGCAGAGGCACTGCCAGGGGGTGGCCGCCACAGCCGCAGCTCCCTCAATACTGTGGTGTAGACGGC
CTGGCCTGTACCCCAACGGTCTGGGAGCACCTGTCTGTTGTAGAAAACACCGGTCCCTGGGGAGACTTGAAAGGCCCCTGTCCCAGCCTG
GACGCCACGCACTGCCGCACGTCACTGGCGGGCTCGCGTGTGTACATAGAGACCACAGCCCGCCTTCTGCCAAAAGAAGTGATGGCCTGC
ACCGAGCTTCCTTGAGGGCTTCAGAAACATGCATAGCTTTGGATCACTGTCTTCTCCTTTATAAATGGCAGAAGAGTGACAAAATTCATT
CAGACCGCACATGTTAGAGGCAGGGAATGAAGAAGGTACTGTGGGCCATGGCCACACCTGATGCGTTTTTGGTGGGCTTACTTGGTGCAG
TGTGCTGTCCAGAGAGACCTGCTGACCCAGTCTGGGACAGGCACAGTGGGAGCTGCCACAGTGCCCCTTGCTGGCCGCCCTCAGGAGGGG
GCCTCTGGACCGTCAGTGTGGCGTAGGCAGTGGGTCTGCTTCAGGGAGGCAGCCTCTTGACTTTGTCACAACGGTTGCACTGAAGATGGC
CCCCACAAGCCCAGTTGTGAATATCAAGGTGACCCTGCCCCTGGCTGGGAGCTCCCCTGGGGCTCTGGAACCTGAAGCCCTGAGAAGGAG
AGCTTGGAAGGAGGTTGAGCTCTTCACTGTGTCTTTCCATCTGGGCTCTGCAGCCCAGCTCTGTGGCAGGAGGCCTGACCCCACCCCATC
AGTCCCTCTCCCAGCATTGCTGTGCATGGCTCCCTCAGGAAGAAGCTCTGGAGTGGGGCCGAGGCCCCAGATGCTCTGCTGGGGTCTGGG
GACTGAGCTGCCTCCTGTCTCTCCACTCTGGAGCCCTGGGCTCTTGCCTCCTGTTGAATTGCCCCTGGGCCTGCCCCCGGCCCCATTTGT
GCCATAAAGGGTTGCTTCATTGCAGGAGGGGTGGCTGAAACCACCATCCTGGGCTGCATCTATCTCCTTAAAGTCCACTCCTTACATCAC
CGCCACTACTGCAGCTCAGTGCCCAGCGGCCGCATGCACACCTCCCGGCCCCTCCTCAGCAGCGCAGGGGCTGGGGGCCCTTCCTGGCAC
CCTTTTGCCTGACGGACCCTGTTGCCTGCTCCTGGGCAGTGGTTTTGTTGCCTGACACAGGGCCTTTAACATTTCTGAGGTTTGGAGATT
AAGCGGGTTCTGTGCGATTTTTAGCACATCCATATCTTTTCTACGTTGAATGTCTGGATCTTTCCTTTGTATGTTTGTGTCTCTGTGTGT
GTATGTGGCCAAGCGTCTGCAGGTGAGGGTGGCACATGGAACTTCACGGGTCACTGGGGGCCCACTCTTCCAGGGTCATCGATGCATCCT
GGGCTGTGCTGAGGCAGTGCTGTCTCGCTCAGTCTTTCCAGACCAGCGGGGCAGCACCTGGGAGGCCTGTCTGAAGCATGCAGTTCTGTG
GTGCTGCTCGGGGATGGACTCCATGCACAGTCCACTTCTTGACACATTCTCACACTGTGGCTGGAGACCCATTTTTTCCATCCCATGTGG
AATGAGAATCTTGAGTTGCCCACAGACAGACTTGACCTTTGTGCCAGAACTGTCCAGAGCTGTGAGTTTTGTTACTGAATTGCCTGTCCC
TGAGCTTGGCCTGCTGGAGCATGATGCTGGAGGCTGTGTGCGGGCAGGCTTGTGCTCCCCTTGGAGAAGGGCTGCTACTTAACAAGGAAG
TCCTGGCCACAGGAGTCCCCTACTGGCTGCAGAGGACGAAGCAGGAAGCATGCCGTGGATCCCACATGCACTGGGGCAGGGCAGCCAGGT
TCCAGAGCAGCAGGCATGTGCATTATGGGTGCCAGGTGGCCAGTGAGGGCCCGAGGACCACGCAGCAGAGTCCCCCACGGGCCTGAGCCT
GAGAGCTCAGAGGATTCCTGCCAGGCCTCAGAACTGTGTGTGCGGGACAGGGTGGCTGGCACGAGATGTGTGGGACTGGGACGCTTCCTT
TGGGGACCAGAGGAACATTAGGGGCCGGTCAGACACGTAGGGGGCAGTGAGGAAACGGGGTAAAGTGGACCATGCAGGCTGCAGAGGGTG
GGCCTTGGGCTGGCCGGGGTTGCTGGGTGGCCCCTTCCCCATGGGCCTCCACAAGCACTCAGGCCACTGGCACGTTGGGCCAGGCAGAAG
GTCCACATGGCAGGGCTGCCTGGAACACCGCTGCCACTGTGGCTCCAGGAGGCCCTTGGGAGCATGAGGAGAGCTGGACTCGCTCATCTG
TTCTTGCACCACCATCCAGAATGCCCCCTTTGCAAGGCCTGCTGCAGTCCCCAGTCTGACCAGCAAGTCCCGGGGTCACCCTTGCTGAAC
CTTGTGCTCCAGGGGTCCTCCTCCTCTAGGACCAGCTTGCCACGGTTTCTCAGAGCCCAGGTGCCCTCTGACCTGCCATGCGGAGGTGGG
ATTTGATACTGTACATTGTCTTGATGCCTGTTTTTTTATGTTTTCATTAAGGGTTTTTAGTTTTTGGTTGGGTTGACACTAACTTTTCTT

>63834_63834_4_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000381551_DGCR2_chr22_19055738_ENST00000545799_length(amino acids)=393AA_BP=191
MSRNGEMFIMGLGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKT
RTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPV
TRSPGGSQEQREVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSRKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLN
GSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAFKDWGVSDTMVHRRLLCPCVGTLHTHLKLGARF

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Fusion Gene PPI Analysis for PDGFB-DGCR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDGFB-DGCR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDGFB-DGCR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource