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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PDGFRL-VPS37A (FusionGDB2 ID:63864)

Fusion Gene Summary for PDGFRL-VPS37A

Fusion gene summary

Fusion gene information	Fusion gene name: PDGFRL-VPS37A
	Fusion gene ID: 63864
		Hgene	Tgene
	Gene symbol	PDGFRL	VPS37A
	Gene ID	5157	137492
	Gene name	platelet derived growth factor receptor like	VPS37A subunit of ESCRT-I
	Synonyms	PDGRL\|PRLTS	HCRP1\|PQBP2\|SPG53
	Cytomap	8p22	8p22
	Type of gene	protein-coding	protein-coding
	Description	platelet-derived growth factor receptor-like proteinPDGF receptor beta-like tumor suppressorPDGFR-like proteinplatelet-derived growth factor-beta-like tumor suppressor	vacuolar protein sorting-associated protein 37AESCRT-I complex subunit VPS37AVPS37A, ESCRT-I subunithepatocellular carcinoma-related protein 1polyglutamine binding protein 2vacuolar protein sorting 37 homolog A
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000251630, ENST00000398074, ENST00000541323, ENST00000523248,	ENST00000324815, ENST00000521005, ENST00000521162, ENST00000521829, ENST00000324849,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 6 X 4=120
	# samples	2	6
	** MAII score	log2(2/8*10)=1.32192809488736	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PDGFRL [Title/Abstract] AND VPS37A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PDGFRL(17447274)-VPS37A(17132242), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PDGFRL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VPS37A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-91-A4BC-01A	PDGFRL	chr8	17447274	-	VPS37A	chr8	17132242	+
ChimerDB4	LUAD	TCGA-91-A4BC-01A	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+

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Fusion Gene ORF analysis for PDGFRL-VPS37A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000251630	ENST00000324815	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000251630	ENST00000521005	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000251630	ENST00000521162	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000251630	ENST00000521829	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000398074	ENST00000324815	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000398074	ENST00000521005	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000398074	ENST00000521162	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000398074	ENST00000521829	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000541323	ENST00000324815	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000541323	ENST00000521005	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000541323	ENST00000521162	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
5CDS-intron	ENST00000541323	ENST00000521829	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
In-frame	ENST00000251630	ENST00000324849	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
In-frame	ENST00000398074	ENST00000324849	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
In-frame	ENST00000541323	ENST00000324849	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
intron-3CDS	ENST00000523248	ENST00000324849	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
intron-intron	ENST00000523248	ENST00000324815	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
intron-intron	ENST00000523248	ENST00000521005	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
intron-intron	ENST00000523248	ENST00000521162	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+
intron-intron	ENST00000523248	ENST00000521829	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000541323

PDGFRL

chr8

17447274

ENST00000324849

VPS37A

chr8

17132242

4614

798

385

1575

396

ENST00000251630

PDGFRL

chr8

17447274

ENST00000324849

VPS37A

chr8

17132242

4610

794

1571

502

ENST00000398074

PDGFRL

chr8

17447274

ENST00000324849

VPS37A

chr8

17132242

4230

414

1191

396

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000541323	ENST00000324849	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+	9.26E-05	0.9999074
ENST00000251630	ENST00000324849	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+	0.000472604	0.99952745
ENST00000398074	ENST00000324849	PDGFRL	chr8	17447274	+	VPS37A	chr8	17132242	+	8.63E-05	0.9999137

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Fusion Genomic Features for PDGFRL-VPS37A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PDGFRL	chr8	17447274	+	VPS37A	chr8	17132241	+	0.00020212	0.9997979
PDGFRL	chr8	17447274	+	VPS37A	chr8	17132241	+	0.00020212	0.9997979

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDGFRL-VPS37A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:17447274/chr8:17132242)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

VPS37A

chr8:17447274

chr8:17132242

ENST00000324815

308_397

186.0

Domain

VPS37 C-terminal

Tgene

VPS37A

chr8:17447274

chr8:17132242

ENST00000324849

308_397

138

1144.3333333333333

Domain

VPS37 C-terminal

Tgene

VPS37A

chr8:17447274

chr8:17132242

ENST00000521829

308_397

113

312.6666666666667

Domain

VPS37 C-terminal

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDGFRL

chr8:17447274

chr8:17132242

ENST00000251630

272_375

117

376.0

Domain

Note=Ig-like C2-type 2

Hgene

PDGFRL

chr8:17447274

chr8:17132242

ENST00000251630

62_159

117

376.0

Domain

Note=Ig-like C2-type 1

Hgene

PDGFRL

chr8:17447274

chr8:17132242

ENST00000398074

272_375

117

376.0

Domain

Note=Ig-like C2-type 2

Hgene

PDGFRL

chr8:17447274

chr8:17132242

ENST00000398074

62_159

117

376.0

Domain

Note=Ig-like C2-type 1

Hgene

PDGFRL

chr8:17447274

chr8:17132242

ENST00000541323

272_375

117

376.0

Domain

Note=Ig-like C2-type 2

Hgene

PDGFRL

chr8:17447274

chr8:17132242

ENST00000541323

62_159

117

376.0

Domain

Note=Ig-like C2-type 1

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Fusion Gene Sequence for PDGFRL-VPS37A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>63864_63864_1_PDGFRL-VPS37A_PDGFRL_chr8_17447274_ENST00000251630_VPS37A_chr8_17132242_ENST00000324849_length(transcript)=4610nt_BP=794nt
ACTTCTGCCTTGTTATCAGAGGAGCGAGGATGTGGCCTGTGTGCCGCCTAATCATGCCTAGAACTGTCTGCACCTGCTGATCTTTTGCTT
CTGCGAACTGGCTGCACCTGCTGTTCTCCTGCTCATACCCTAGCCCGTGCTTACCCTAATTCCCTGTTCTCCTGCCTCACCACCAGAGGC
CCGGGTTGTCTGCACAGTCTCATTTTCCACGTTATTCCTGTAATGAACCCGTCCTCCCACCCCCACCAGCAGTTACAGGGCTGGGTGCGG
AGACCAACTCTGGCCAGACACAGAGGAGCAGCAAGAACCCGGGGCAACGGTCCTAAACCGAATCCTCCCGCTTCGGCGTCCCAGGAGCCC
GCCCCTCGCCCGCCGCCTCCCCTGCGTCCCCGCCCCGCGCAGCCGCCGCGCTCCTGCGCTCCGAGGTCCGAGGTTCCCGAGATGAAGGTC
TGGCTGCTGCTTGGTCTTCTGCTGGTGCACGAAGCGCTGGAGGATGTTACTGGCCAACACCTTCCCAAGAACAAGCGTCCAAAAGAACCA
GGAGAGAATAGAATCAAACCTACCAACAAGAAGGTGAAGCCCAAAATTCCTAAAATGAAGGACAGGGACTCAGCCAATTCAGCACCAAAG
ACGCAGTCTATCATGATGCAAGTGCTGGATAAAGGTCGCTTCCAGAAACCCGCCGCTACCCTGAGTCTGCTGGCGGGGCAAACTGTAGAG
CTTCGATGTAAAGGGAGTAGAATTGGGTGGAGCTACCCTGCGTATCTGGACACCTTTAAGGATTCTCGCCTCAGTCTATACAGTAACCCA
AGTGGGATGTCTCCTTATGCTTCTCAGGGTTTTCCATTTCTTCCTCCATATCCTCCACAAGAAGCAAACAGGAGTATCACTTCTTTATCT
GTTGCTGACACTGTTTCTTCTTCAACAACAAGTCATACCACAGCCAAGCCTGCCGCTCCTTCATTTGGTGTCCTTTCAAATCTGCCATTA
CCCATTCCCACAGTGGATGCTTCAATACCGACAAGCCAAAATGGTTTTGGGTACAAGATGCCAGATGTCCCTGATGCATTTCCAGAACTC
TCAGAACTAAGTGTGTCACAACTCACAGATATGAATGAACAAGAGGAGGTATTACTAGAACAGTTTCTGACTTTGCCTCAACTAAAACAA
ATTATTACCGACAAAGATGACTTAGTAAAAAGTATTGAGGAACTAGCAAGAAAAAATCTCCTTTTGGAGCCCAGCTTGGAAGCCAAAAGA
CAAACTGTTTTAGATAAGTATGAATTACTTACACAGATGAAGTCCACTTTCGAAAAGAAGATGCAAAGGCAGCATGAACTTAGTGAGAGC
TGTAGTGCAAGTGCCCTTCAGGCAAGATTGAAAGTAGCTGCACATGAAGCTGAGGAAGAATCTGATAATATTGCAGAAGACTTCTTGGAG
GGAAAGATGGAAATAGATGATTTTCTCAGTAGCTTCATGGAAAAGAGAACAATTTGCCACTGTAGAAGAGCCAAGGAAGAGAAACTTCAG
CAGGCGATAGCAATGCACAGCCAATTTCATGCTCCACTATAGATTTTCCTGGAAACATGAACTGCCAAGAGAGGAATGGGACACAAAACC
AAACACTGTTTTATATTTATGGTTTGCAAACTGGCATTTCATCAGTGGCTAAATTCACAGATATCCTATATAGATTGTATACAGAACTGA
GACTGATTTTGTACCGATTAGAATGATTGCTATGATCTTTGAGAAATTTTTCTGCACTATTTGCACTGAAATGTTTATTTATTGTTGATA
AATTGTATCATATTTAAGTTCCACTGCTGTTCCTCTTACCTTGATTAAATGCCTATGCATGTACTTTTAGCTAGTTTTTAATATTTTATA
AAACTTCATTTAAATTTGTATTTTTAACTTGAAGTTCCATTTCTTTATCAAGGATGGTATTTAGATTTTTTTCCTCTTAACCTTTTTTCA
AAAACTATTTTCAACTGTGAGGAAACCCTTATTTTTCTTTCTTTGTGGATAAAACTTTCAAAAGCAATTTAAGATATTCATAGTGTTAGG
AAACACCAAACCTGCCTATGTGCCATCTCACAAAAGAAACTTTTAATACCTACAATAAATCAAAAGAATAAACCAGCTGTTCTTATATAT
TGTTTCATTTTTAAAACTAAAGATGCATTTAAGAAGCAATACAAGTAAATATTTTACCTAATAGGAAAAAAAAAAGTTGCCTTTCATTTA
AACCATTCCAACAGAAATTCTTATGCTAATTTAAAACATATATATATCTGGTAGGTTTGTGGTTGGATAGGTTTTCTAAATTCCTAATGT
TAAAAACAATCTTTATGTTAATATACACTAAATCTATACACAAAAAAAGTCAGTGAACTTTTCTGACCTTTACTGTGAGTTACCTTTTCC
TAAGAGGAAAGCTATAGTAATAAGTAAAATTTAATTTTTAGGCAATCCTGATTTTTAATGAATTTAATTGAGTGTTCTTGTATACTACAT
TGAGCAGTTTGCTTCTATACCGTGTCACAAAATTCATGTATTTCTTGAGAAGCCCTAAAAGCTCATAAAGGAAAATGCCGTGAACTATGT
AGCTCAGGCTTGGTAAGGTGCCATCTAAATTACAAAACAAACTAATGCATAATTTTGCTTAAATTTCATCCCAGTATGATTGTCTTCCCA
ACACCAGCATATAGTATAGATTGTCTGTCTTTTTTATATTTTTTAGTTCTTCCTGTACATGTTTTTGGCAATAAAGTTATAGGAAGAACA
AAATTATTTTGTTAGAATTAAAACATGCTTAATATTTAGTCTGTTTGTGGAGGGCAGGTATTCACGTGGACTGAGATACAATGTTGGATA
CAGAAAATAACTTTCATTGTCTTCCTGACACTGTGCTAAGGACATGCTGTTAAAGCTTCAAAGTGACCAGATGAGGAAGGAATAATTAAT
TATTACTCCTGATTTGTAGATAACTGAGGTAAGAGTGTTTCAAATTTATGATAGTCTTTTGGGTATTCAGAAACCTTTCCTTATACTGCA
CTGGCCACCAGAGCTTAATTTTCCCAGCAGTTACAGCAATGGGAGATAGAACAGTCTCAATCTTTTGCCAACCATCAGGTTCCTAGAAAC
CAGGTAGGTGTATCCCATAACAAGGGAGGAGCATACCACAGCCCCTCATTTGATTAATTCATTTGATCTATCTATGTTATTAAGTACCTA
CTAGGAATAAGGCATTGTGGAAATACTATACAAAGATAAACATTGTTTAGATGCTTATCTACTTTCCTTTTCACCAGAAAAACAGAAAAA
AAAGAAACATTTTCTTACAGAGTAAAAATGTTCTACATAATCACATGAGTAGTTCATCTCAGTGTTTTTTATTCTTTAAAGTTGAACTAT
CCCAGTTTCATTCTATACCATTCATTGGATAACCTTGTTACAACCCAGTCATGAAACAGAGCAGTGTGATCAGTTATCTGCATTTAACAA
ATAGACAAATCAGTTTACATAAAGGTTATGTATGTCACCCACGATGAAAAGAATCTGCATTTGAATATGCCCGTATGAATGTGGGTTCTG
TTTTTGCAACAGAGATTAAGTGACCATTTTTTCTAATTTTATGGCTATATATTTTCTTCATAAAAATTGGTCACATCGGAGAAGCAGTGC
CACAGGAAAAATGAAATGCATGTGAAAGTTTGTATTCTGATTTTACAAGATGAGATAGAAATCAGAATTAAAGAGGAATACTTAGGAGTT
ACTAGGCTAATCAGTGTACGAATTTGTCATAGGTAGAGATTTAAAGGTTAATATCTTAAAATAGAAGAAAATTCTAAATCAATCAATCAG
TGAGATATAAACTAAACAGACCCACTTCAAAGTTGAAAGAAATTTCTAGGCATAAATTGAGACTAGGAAATTTATATCAGAATAGAGGGT
GCTTGACACATATATATGCTTAAATTGAAGGACAGCTCAGATTCATTTTTAGGAGAAGAAAGTAAACTAATGTGCTCTTAAAGAATAAAA
ATTTATTCTATGGTTTCTGTCTCTGATCATCACCTTCCATTCTATAAAAAGCTCAGTTACTGATTTGCTGGGTCATGGTCAAAATTCTTA
CCTATTTATTTCATATCAACTTTAAAAAATAAATTACTTGCATTCTATATATTACTAATTGGGAAGTAATATGCCTCAAATCAGTTTTAT
ACTGGATTATTCCCTATGCTTTAAACCACTGCTCTCAATAAAACACTTCCTGATTAATGTTTGATTATTAGATATTTTAGTCTTGTTGGG
GATATTTTAGTCTTGTTGGGTTAGCCATGCTCTGAAGAATCTGTGAAAGTACAGTAAAGTTTTAATAAGCAATAAATGTAACCTTTTATA
TAAATCTCAGTGCTAGGTTAACTTCTAATAAGCAGACGAACATGTTACATAAATTATAATGTCTGTCTTGTAAAAAAGTTGAGGGGACTA
AAAGTTTATGACTCTGATATGGAAGTTGTCATATTAAAAAACTACATTTTAAAACATCAAATATTTATACTATTTGCTTTTCAAATAAAA

>63864_63864_1_PDGFRL-VPS37A_PDGFRL_chr8_17447274_ENST00000251630_VPS37A_chr8_17132242_ENST00000324849_length(amino acids)=502AA_BP=243
MSAPADLLLLRTGCTCCSPAHTLARAYPNSLFSCLTTRGPGCLHSLIFHVIPVMNPSSHPHQQLQGWVRRPTLARHRGAARTRGNGPKPN
PPASASQEPAPRPPPPLRPRPAQPPRSCAPRSEVPEMKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKD
RDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSLYSNPSGMSPYASQGFPFLPPYPPQE
ANRSITSLSVADTVSSSTTSHTTAKPAAPSFGVLSNLPLPIPTVDASIPTSQNGFGYKMPDVPDAFPELSELSVSQLTDMNEQEEVLLEQ
FLTLPQLKQIITDKDDLVKSIEELARKNLLLEPSLEAKRQTVLDKYELLTQMKSTFEKKMQRQHELSESCSASALQARLKVAAHEAEEES

--------------------------------------------------------------
>63864_63864_2_PDGFRL-VPS37A_PDGFRL_chr8_17447274_ENST00000398074_VPS37A_chr8_17132242_ENST00000324849_length(transcript)=4230nt_BP=414nt
CCTGCGTCCCCGCCCCGCGCAGCCGCCGCGCTCCTGCGCTCCGAGGTCCGAGGTTCCCGAGATGAAGGTCTGGCTGCTGCTTGGTCTTCT
GCTGGTGCACGAAGCGCTGGAGGATGTTACTGGCCAACACCTTCCCAAGAACAAGCGTCCAAAAGAACCAGGAGAGAATAGAATCAAACC
TACCAACAAGAAGGTGAAGCCCAAAATTCCTAAAATGAAGGACAGGGACTCAGCCAATTCAGCACCAAAGACGCAGTCTATCATGATGCA
AGTGCTGGATAAAGGTCGCTTCCAGAAACCCGCCGCTACCCTGAGTCTGCTGGCGGGGCAAACTGTAGAGCTTCGATGTAAAGGGAGTAG
AATTGGGTGGAGCTACCCTGCGTATCTGGACACCTTTAAGGATTCTCGCCTCAGTCTATACAGTAACCCAAGTGGGATGTCTCCTTATGC
TTCTCAGGGTTTTCCATTTCTTCCTCCATATCCTCCACAAGAAGCAAACAGGAGTATCACTTCTTTATCTGTTGCTGACACTGTTTCTTC
TTCAACAACAAGTCATACCACAGCCAAGCCTGCCGCTCCTTCATTTGGTGTCCTTTCAAATCTGCCATTACCCATTCCCACAGTGGATGC
TTCAATACCGACAAGCCAAAATGGTTTTGGGTACAAGATGCCAGATGTCCCTGATGCATTTCCAGAACTCTCAGAACTAAGTGTGTCACA
ACTCACAGATATGAATGAACAAGAGGAGGTATTACTAGAACAGTTTCTGACTTTGCCTCAACTAAAACAAATTATTACCGACAAAGATGA
CTTAGTAAAAAGTATTGAGGAACTAGCAAGAAAAAATCTCCTTTTGGAGCCCAGCTTGGAAGCCAAAAGACAAACTGTTTTAGATAAGTA
TGAATTACTTACACAGATGAAGTCCACTTTCGAAAAGAAGATGCAAAGGCAGCATGAACTTAGTGAGAGCTGTAGTGCAAGTGCCCTTCA
GGCAAGATTGAAAGTAGCTGCACATGAAGCTGAGGAAGAATCTGATAATATTGCAGAAGACTTCTTGGAGGGAAAGATGGAAATAGATGA
TTTTCTCAGTAGCTTCATGGAAAAGAGAACAATTTGCCACTGTAGAAGAGCCAAGGAAGAGAAACTTCAGCAGGCGATAGCAATGCACAG
CCAATTTCATGCTCCACTATAGATTTTCCTGGAAACATGAACTGCCAAGAGAGGAATGGGACACAAAACCAAACACTGTTTTATATTTAT
GGTTTGCAAACTGGCATTTCATCAGTGGCTAAATTCACAGATATCCTATATAGATTGTATACAGAACTGAGACTGATTTTGTACCGATTA
GAATGATTGCTATGATCTTTGAGAAATTTTTCTGCACTATTTGCACTGAAATGTTTATTTATTGTTGATAAATTGTATCATATTTAAGTT
CCACTGCTGTTCCTCTTACCTTGATTAAATGCCTATGCATGTACTTTTAGCTAGTTTTTAATATTTTATAAAACTTCATTTAAATTTGTA
TTTTTAACTTGAAGTTCCATTTCTTTATCAAGGATGGTATTTAGATTTTTTTCCTCTTAACCTTTTTTCAAAAACTATTTTCAACTGTGA
GGAAACCCTTATTTTTCTTTCTTTGTGGATAAAACTTTCAAAAGCAATTTAAGATATTCATAGTGTTAGGAAACACCAAACCTGCCTATG
TGCCATCTCACAAAAGAAACTTTTAATACCTACAATAAATCAAAAGAATAAACCAGCTGTTCTTATATATTGTTTCATTTTTAAAACTAA
AGATGCATTTAAGAAGCAATACAAGTAAATATTTTACCTAATAGGAAAAAAAAAAGTTGCCTTTCATTTAAACCATTCCAACAGAAATTC
TTATGCTAATTTAAAACATATATATATCTGGTAGGTTTGTGGTTGGATAGGTTTTCTAAATTCCTAATGTTAAAAACAATCTTTATGTTA
ATATACACTAAATCTATACACAAAAAAAGTCAGTGAACTTTTCTGACCTTTACTGTGAGTTACCTTTTCCTAAGAGGAAAGCTATAGTAA
TAAGTAAAATTTAATTTTTAGGCAATCCTGATTTTTAATGAATTTAATTGAGTGTTCTTGTATACTACATTGAGCAGTTTGCTTCTATAC
CGTGTCACAAAATTCATGTATTTCTTGAGAAGCCCTAAAAGCTCATAAAGGAAAATGCCGTGAACTATGTAGCTCAGGCTTGGTAAGGTG
CCATCTAAATTACAAAACAAACTAATGCATAATTTTGCTTAAATTTCATCCCAGTATGATTGTCTTCCCAACACCAGCATATAGTATAGA
TTGTCTGTCTTTTTTATATTTTTTAGTTCTTCCTGTACATGTTTTTGGCAATAAAGTTATAGGAAGAACAAAATTATTTTGTTAGAATTA
AAACATGCTTAATATTTAGTCTGTTTGTGGAGGGCAGGTATTCACGTGGACTGAGATACAATGTTGGATACAGAAAATAACTTTCATTGT
CTTCCTGACACTGTGCTAAGGACATGCTGTTAAAGCTTCAAAGTGACCAGATGAGGAAGGAATAATTAATTATTACTCCTGATTTGTAGA
TAACTGAGGTAAGAGTGTTTCAAATTTATGATAGTCTTTTGGGTATTCAGAAACCTTTCCTTATACTGCACTGGCCACCAGAGCTTAATT
TTCCCAGCAGTTACAGCAATGGGAGATAGAACAGTCTCAATCTTTTGCCAACCATCAGGTTCCTAGAAACCAGGTAGGTGTATCCCATAA
CAAGGGAGGAGCATACCACAGCCCCTCATTTGATTAATTCATTTGATCTATCTATGTTATTAAGTACCTACTAGGAATAAGGCATTGTGG
AAATACTATACAAAGATAAACATTGTTTAGATGCTTATCTACTTTCCTTTTCACCAGAAAAACAGAAAAAAAAGAAACATTTTCTTACAG
AGTAAAAATGTTCTACATAATCACATGAGTAGTTCATCTCAGTGTTTTTTATTCTTTAAAGTTGAACTATCCCAGTTTCATTCTATACCA
TTCATTGGATAACCTTGTTACAACCCAGTCATGAAACAGAGCAGTGTGATCAGTTATCTGCATTTAACAAATAGACAAATCAGTTTACAT
AAAGGTTATGTATGTCACCCACGATGAAAAGAATCTGCATTTGAATATGCCCGTATGAATGTGGGTTCTGTTTTTGCAACAGAGATTAAG
TGACCATTTTTTCTAATTTTATGGCTATATATTTTCTTCATAAAAATTGGTCACATCGGAGAAGCAGTGCCACAGGAAAAATGAAATGCA
TGTGAAAGTTTGTATTCTGATTTTACAAGATGAGATAGAAATCAGAATTAAAGAGGAATACTTAGGAGTTACTAGGCTAATCAGTGTACG
AATTTGTCATAGGTAGAGATTTAAAGGTTAATATCTTAAAATAGAAGAAAATTCTAAATCAATCAATCAGTGAGATATAAACTAAACAGA
CCCACTTCAAAGTTGAAAGAAATTTCTAGGCATAAATTGAGACTAGGAAATTTATATCAGAATAGAGGGTGCTTGACACATATATATGCT
TAAATTGAAGGACAGCTCAGATTCATTTTTAGGAGAAGAAAGTAAACTAATGTGCTCTTAAAGAATAAAAATTTATTCTATGGTTTCTGT
CTCTGATCATCACCTTCCATTCTATAAAAAGCTCAGTTACTGATTTGCTGGGTCATGGTCAAAATTCTTACCTATTTATTTCATATCAAC
TTTAAAAAATAAATTACTTGCATTCTATATATTACTAATTGGGAAGTAATATGCCTCAAATCAGTTTTATACTGGATTATTCCCTATGCT
TTAAACCACTGCTCTCAATAAAACACTTCCTGATTAATGTTTGATTATTAGATATTTTAGTCTTGTTGGGGATATTTTAGTCTTGTTGGG
TTAGCCATGCTCTGAAGAATCTGTGAAAGTACAGTAAAGTTTTAATAAGCAATAAATGTAACCTTTTATATAAATCTCAGTGCTAGGTTA
ACTTCTAATAAGCAGACGAACATGTTACATAAATTATAATGTCTGTCTTGTAAAAAAGTTGAGGGGACTAAAAGTTTATGACTCTGATAT
GGAAGTTGTCATATTAAAAAACTACATTTTAAAACATCAAATATTTATACTATTTGCTTTTCAAATAAAAGCATAGTGCTGTTTGGCATA

>63864_63864_2_PDGFRL-VPS37A_PDGFRL_chr8_17447274_ENST00000398074_VPS37A_chr8_17132242_ENST00000324849_length(amino acids)=396AA_BP=137
LRPRPAQPPRSCAPRSEVPEMKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANSAPKTQSIMMQ
VLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSLYSNPSGMSPYASQGFPFLPPYPPQEANRSITSLSVADTVSS
STTSHTTAKPAAPSFGVLSNLPLPIPTVDASIPTSQNGFGYKMPDVPDAFPELSELSVSQLTDMNEQEEVLLEQFLTLPQLKQIITDKDD
LVKSIEELARKNLLLEPSLEAKRQTVLDKYELLTQMKSTFEKKMQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKMEIDD

--------------------------------------------------------------
>63864_63864_3_PDGFRL-VPS37A_PDGFRL_chr8_17447274_ENST00000541323_VPS37A_chr8_17132242_ENST00000324849_length(transcript)=4614nt_BP=798nt
ACTTCTGCCTTGTTATCAGAGGAGCGAGGATGTGGCCTGTGTGCCGCCTAATCATGCCTAGAACTGTCTGCACCTGCTGATCTTTTGCTT
CTGCGAACTGGCTGCACCTGCTGTTCTCCTGCTCATACCCTAGCCCGTGCTTACCCTAATTCCCTGTTCTCCTGCCTCACCACCAGAGGC
CCGGGTTGTCTGCACAGTCTCATTTTCCACGTTATTCCTGTAATGAACCCGTCCTCCCACCCCCACCAGCAGTTACAGGGCTGGGTGCGG
AGACCAACTCTGGCCAGACACAGAGGAGCAGCAAGAACCCGGGGCAACGGTCCTGTGAAAACCGAATCCTCCCGCTTCGGCGTCCCAGGA
GCCCGCCCCTCGCCCGCCGCCTCCCCTGCGTCCCCGCCCCGCGCAGCCGCCGCGCTCCTGCGCTCCGAGGTCCGAGGTTCCCGAGATGAA
GGTCTGGCTGCTGCTTGGTCTTCTGCTGGTGCACGAAGCGCTGGAGGATGTTACTGGCCAACACCTTCCCAAGAACAAGCGTCCAAAAGA
ACCAGGAGAGAATAGAATCAAACCTACCAACAAGAAGGTGAAGCCCAAAATTCCTAAAATGAAGGACAGGGACTCAGCCAATTCAGCACC
AAAGACGCAGTCTATCATGATGCAAGTGCTGGATAAAGGTCGCTTCCAGAAACCCGCCGCTACCCTGAGTCTGCTGGCGGGGCAAACTGT
AGAGCTTCGATGTAAAGGGAGTAGAATTGGGTGGAGCTACCCTGCGTATCTGGACACCTTTAAGGATTCTCGCCTCAGTCTATACAGTAA
CCCAAGTGGGATGTCTCCTTATGCTTCTCAGGGTTTTCCATTTCTTCCTCCATATCCTCCACAAGAAGCAAACAGGAGTATCACTTCTTT
ATCTGTTGCTGACACTGTTTCTTCTTCAACAACAAGTCATACCACAGCCAAGCCTGCCGCTCCTTCATTTGGTGTCCTTTCAAATCTGCC
ATTACCCATTCCCACAGTGGATGCTTCAATACCGACAAGCCAAAATGGTTTTGGGTACAAGATGCCAGATGTCCCTGATGCATTTCCAGA
ACTCTCAGAACTAAGTGTGTCACAACTCACAGATATGAATGAACAAGAGGAGGTATTACTAGAACAGTTTCTGACTTTGCCTCAACTAAA
ACAAATTATTACCGACAAAGATGACTTAGTAAAAAGTATTGAGGAACTAGCAAGAAAAAATCTCCTTTTGGAGCCCAGCTTGGAAGCCAA
AAGACAAACTGTTTTAGATAAGTATGAATTACTTACACAGATGAAGTCCACTTTCGAAAAGAAGATGCAAAGGCAGCATGAACTTAGTGA
GAGCTGTAGTGCAAGTGCCCTTCAGGCAAGATTGAAAGTAGCTGCACATGAAGCTGAGGAAGAATCTGATAATATTGCAGAAGACTTCTT
GGAGGGAAAGATGGAAATAGATGATTTTCTCAGTAGCTTCATGGAAAAGAGAACAATTTGCCACTGTAGAAGAGCCAAGGAAGAGAAACT
TCAGCAGGCGATAGCAATGCACAGCCAATTTCATGCTCCACTATAGATTTTCCTGGAAACATGAACTGCCAAGAGAGGAATGGGACACAA
AACCAAACACTGTTTTATATTTATGGTTTGCAAACTGGCATTTCATCAGTGGCTAAATTCACAGATATCCTATATAGATTGTATACAGAA
CTGAGACTGATTTTGTACCGATTAGAATGATTGCTATGATCTTTGAGAAATTTTTCTGCACTATTTGCACTGAAATGTTTATTTATTGTT
GATAAATTGTATCATATTTAAGTTCCACTGCTGTTCCTCTTACCTTGATTAAATGCCTATGCATGTACTTTTAGCTAGTTTTTAATATTT
TATAAAACTTCATTTAAATTTGTATTTTTAACTTGAAGTTCCATTTCTTTATCAAGGATGGTATTTAGATTTTTTTCCTCTTAACCTTTT
TTCAAAAACTATTTTCAACTGTGAGGAAACCCTTATTTTTCTTTCTTTGTGGATAAAACTTTCAAAAGCAATTTAAGATATTCATAGTGT
TAGGAAACACCAAACCTGCCTATGTGCCATCTCACAAAAGAAACTTTTAATACCTACAATAAATCAAAAGAATAAACCAGCTGTTCTTAT
ATATTGTTTCATTTTTAAAACTAAAGATGCATTTAAGAAGCAATACAAGTAAATATTTTACCTAATAGGAAAAAAAAAAGTTGCCTTTCA
TTTAAACCATTCCAACAGAAATTCTTATGCTAATTTAAAACATATATATATCTGGTAGGTTTGTGGTTGGATAGGTTTTCTAAATTCCTA
ATGTTAAAAACAATCTTTATGTTAATATACACTAAATCTATACACAAAAAAAGTCAGTGAACTTTTCTGACCTTTACTGTGAGTTACCTT
TTCCTAAGAGGAAAGCTATAGTAATAAGTAAAATTTAATTTTTAGGCAATCCTGATTTTTAATGAATTTAATTGAGTGTTCTTGTATACT
ACATTGAGCAGTTTGCTTCTATACCGTGTCACAAAATTCATGTATTTCTTGAGAAGCCCTAAAAGCTCATAAAGGAAAATGCCGTGAACT
ATGTAGCTCAGGCTTGGTAAGGTGCCATCTAAATTACAAAACAAACTAATGCATAATTTTGCTTAAATTTCATCCCAGTATGATTGTCTT
CCCAACACCAGCATATAGTATAGATTGTCTGTCTTTTTTATATTTTTTAGTTCTTCCTGTACATGTTTTTGGCAATAAAGTTATAGGAAG
AACAAAATTATTTTGTTAGAATTAAAACATGCTTAATATTTAGTCTGTTTGTGGAGGGCAGGTATTCACGTGGACTGAGATACAATGTTG
GATACAGAAAATAACTTTCATTGTCTTCCTGACACTGTGCTAAGGACATGCTGTTAAAGCTTCAAAGTGACCAGATGAGGAAGGAATAAT
TAATTATTACTCCTGATTTGTAGATAACTGAGGTAAGAGTGTTTCAAATTTATGATAGTCTTTTGGGTATTCAGAAACCTTTCCTTATAC
TGCACTGGCCACCAGAGCTTAATTTTCCCAGCAGTTACAGCAATGGGAGATAGAACAGTCTCAATCTTTTGCCAACCATCAGGTTCCTAG
AAACCAGGTAGGTGTATCCCATAACAAGGGAGGAGCATACCACAGCCCCTCATTTGATTAATTCATTTGATCTATCTATGTTATTAAGTA
CCTACTAGGAATAAGGCATTGTGGAAATACTATACAAAGATAAACATTGTTTAGATGCTTATCTACTTTCCTTTTCACCAGAAAAACAGA
AAAAAAAGAAACATTTTCTTACAGAGTAAAAATGTTCTACATAATCACATGAGTAGTTCATCTCAGTGTTTTTTATTCTTTAAAGTTGAA
CTATCCCAGTTTCATTCTATACCATTCATTGGATAACCTTGTTACAACCCAGTCATGAAACAGAGCAGTGTGATCAGTTATCTGCATTTA
ACAAATAGACAAATCAGTTTACATAAAGGTTATGTATGTCACCCACGATGAAAAGAATCTGCATTTGAATATGCCCGTATGAATGTGGGT
TCTGTTTTTGCAACAGAGATTAAGTGACCATTTTTTCTAATTTTATGGCTATATATTTTCTTCATAAAAATTGGTCACATCGGAGAAGCA
GTGCCACAGGAAAAATGAAATGCATGTGAAAGTTTGTATTCTGATTTTACAAGATGAGATAGAAATCAGAATTAAAGAGGAATACTTAGG
AGTTACTAGGCTAATCAGTGTACGAATTTGTCATAGGTAGAGATTTAAAGGTTAATATCTTAAAATAGAAGAAAATTCTAAATCAATCAA
TCAGTGAGATATAAACTAAACAGACCCACTTCAAAGTTGAAAGAAATTTCTAGGCATAAATTGAGACTAGGAAATTTATATCAGAATAGA
GGGTGCTTGACACATATATATGCTTAAATTGAAGGACAGCTCAGATTCATTTTTAGGAGAAGAAAGTAAACTAATGTGCTCTTAAAGAAT
AAAAATTTATTCTATGGTTTCTGTCTCTGATCATCACCTTCCATTCTATAAAAAGCTCAGTTACTGATTTGCTGGGTCATGGTCAAAATT
CTTACCTATTTATTTCATATCAACTTTAAAAAATAAATTACTTGCATTCTATATATTACTAATTGGGAAGTAATATGCCTCAAATCAGTT
TTATACTGGATTATTCCCTATGCTTTAAACCACTGCTCTCAATAAAACACTTCCTGATTAATGTTTGATTATTAGATATTTTAGTCTTGT
TGGGGATATTTTAGTCTTGTTGGGTTAGCCATGCTCTGAAGAATCTGTGAAAGTACAGTAAAGTTTTAATAAGCAATAAATGTAACCTTT
TATATAAATCTCAGTGCTAGGTTAACTTCTAATAAGCAGACGAACATGTTACATAAATTATAATGTCTGTCTTGTAAAAAAGTTGAGGGG
ACTAAAAGTTTATGACTCTGATATGGAAGTTGTCATATTAAAAAACTACATTTTAAAACATCAAATATTTATACTATTTGCTTTTCAAAT

>63864_63864_3_PDGFRL-VPS37A_PDGFRL_chr8_17447274_ENST00000541323_VPS37A_chr8_17132242_ENST00000324849_length(amino acids)=396AA_BP=137
MRPRPAQPPRSCAPRSEVPEMKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANSAPKTQSIMMQ
VLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSLYSNPSGMSPYASQGFPFLPPYPPQEANRSITSLSVADTVSS
STTSHTTAKPAAPSFGVLSNLPLPIPTVDASIPTSQNGFGYKMPDVPDAFPELSELSVSQLTDMNEQEEVLLEQFLTLPQLKQIITDKDD
LVKSIEELARKNLLLEPSLEAKRQTVLDKYELLTQMKSTFEKKMQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKMEIDD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PDGFRL-VPS37A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PDGFRL-VPS37A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PDGFRL-VPS37A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source