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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PDIA3-SF3B1 (FusionGDB2 ID:63894)

Fusion Gene Summary for PDIA3-SF3B1

Fusion gene summary

Fusion gene information	Fusion gene name: PDIA3-SF3B1
	Fusion gene ID: 63894
		Hgene	Tgene
	Gene symbol	PDIA3	SF3B1
	Gene ID	2923	23451
	Gene name	protein disulfide isomerase family A member 3	splicing factor 3b subunit 1
	Synonyms	ER60\|ERp57\|ERp60\|ERp61\|GRP57\|GRP58\|HEL-S-269\|HEL-S-93n\|HsT17083\|P58\|PI-PLC	Hsh155\|MDS\|PRP10\|PRPF10\|SAP155\|SF3b155
	Cytomap	15q15.3	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	protein disulfide-isomerase A358 kDa glucose-regulated protein58 kDa microsomal proteinER protein 57ER protein 60disulfide isomerase ER-60endoplasmic reticulum P58endoplasmic reticulum resident protein 57endoplasmic reticulum resident protein 60e	splicing factor 3B subunit 1pre-mRNA processing 10pre-mRNA splicing factor SF3b, 155 kDa subunitspliceosome-associated protein 155splicing factor 3b, subunit 1, 155kDa
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000300289, ENST00000538521, ENST00000469684,	ENST00000409915, ENST00000414963, ENST00000462613, ENST00000487698, ENST00000335508,
Fusion gene scores	* DoF score	13 X 14 X 5=910	6 X 8 X 4=192
	# samples	16	9
	** MAII score	log2(16/910*10)=-2.5077946401987 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PDIA3 [Title/Abstract] AND SF3B1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PDIA3(44059108)-SF3B1(198257912), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SF3B1	GO:0000398	mRNA splicing, via spliceosome	11252167\|28781166\|29360106

Fusion gene breakpoints across PDIA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SF3B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A49W	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-

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Fusion Gene ORF analysis for PDIA3-SF3B1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000300289	ENST00000409915	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
5CDS-intron	ENST00000300289	ENST00000414963	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
5CDS-intron	ENST00000300289	ENST00000462613	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
5CDS-intron	ENST00000300289	ENST00000487698	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
5CDS-intron	ENST00000538521	ENST00000409915	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
5CDS-intron	ENST00000538521	ENST00000414963	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
5CDS-intron	ENST00000538521	ENST00000462613	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
5CDS-intron	ENST00000538521	ENST00000487698	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
In-frame	ENST00000300289	ENST00000335508	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
In-frame	ENST00000538521	ENST00000335508	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
intron-3CDS	ENST00000469684	ENST00000335508	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
intron-intron	ENST00000469684	ENST00000409915	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
intron-intron	ENST00000469684	ENST00000414963	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
intron-intron	ENST00000469684	ENST00000462613	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-
intron-intron	ENST00000469684	ENST00000487698	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000300289

PDIA3

chr15

44059108

ENST00000335508

SF3B1

chr2

198257912

4071

1176

1551

514

ENST00000538521

PDIA3

chr15

44059108

ENST00000335508

SF3B1

chr2

198257912

4185

1290

217

1665

482

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000300289	ENST00000335508	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-	0.000129753	0.9998702
ENST00000538521	ENST00000335508	PDIA3	chr15	44059108	+	SF3B1	chr2	198257912	-	0.000383986	0.999616

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Fusion Genomic Features for PDIA3-SF3B1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDIA3-SF3B1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:44059108/chr2:198257912)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDIA3

chr15:44059108

chr2:198257912

ENST00000300289

25_133

342

506.0

Domain

Thioredoxin 1

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

1010_1048

88.0

Repeat

Note=HEAT 8

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

1052_1090

88.0

Repeat

Note=HEAT 9

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

1122_1160

88.0

Repeat

Note=HEAT 10

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

1163_1201

88.0

Repeat

Note=HEAT 11

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

569_603

88.0

Repeat

Note=HEAT 2

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

604_641

88.0

Repeat

Note=HEAT 3

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

643_677

88.0

Repeat

Note=HEAT 4

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

680_718

88.0

Repeat

Note=HEAT 5

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

763_801

88.0

Repeat

Note=HEAT 6

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000409915

843_881

88.0

Repeat

Note=HEAT 7

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

1010_1048

145.0

Repeat

Note=HEAT 8

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

1052_1090

145.0

Repeat

Note=HEAT 9

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

1122_1160

145.0

Repeat

Note=HEAT 10

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

1163_1201

145.0

Repeat

Note=HEAT 11

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

569_603

145.0

Repeat

Note=HEAT 2

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

604_641

145.0

Repeat

Note=HEAT 3

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

643_677

145.0

Repeat

Note=HEAT 4

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

680_718

145.0

Repeat

Note=HEAT 5

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

763_801

145.0

Repeat

Note=HEAT 6

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000414963

843_881

145.0

Repeat

Note=HEAT 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDIA3

chr15:44059108

chr2:198257912

ENST00000300289

343_485

342

506.0

Domain

Thioredoxin 2

Hgene

PDIA3

chr15:44059108

chr2:198257912

ENST00000300289

502_505

342

506.0

Motif

Prevents secretion from ER

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

1010_1048

1179

1305.0

Repeat

Note=HEAT 8

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

1052_1090

1179

1305.0

Repeat

Note=HEAT 9

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

1122_1160

1179

1305.0

Repeat

Note=HEAT 10

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

1163_1201

1179

1305.0

Repeat

Note=HEAT 11

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

569_603

1179

1305.0

Repeat

Note=HEAT 2

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

604_641

1179

1305.0

Repeat

Note=HEAT 3

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

643_677

1179

1305.0

Repeat

Note=HEAT 4

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

680_718

1179

1305.0

Repeat

Note=HEAT 5

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

763_801

1179

1305.0

Repeat

Note=HEAT 6

Tgene

SF3B1

chr15:44059108

chr2:198257912

ENST00000335508

843_881

1179

1305.0

Repeat

Note=HEAT 7

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Fusion Gene Sequence for PDIA3-SF3B1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>63894_63894_1_PDIA3-SF3B1_PDIA3_chr15_44059108_ENST00000300289_SF3B1_chr2_198257912_ENST00000335508_length(transcript)=4071nt_BP=1176nt
GCCGGGTTTGGGGGTTGGGACCTCCGGCTGCAGGTCCGCCTGGGCCAGACGCGCGAGCGCAAGCAGCGGGTTAGTGGTCGCGCGCCCGAC
CTCCGCAGTCCCAGCCGAGCCGCGACCCTTCCGGCCGTCCCCACCCCACCTCGCCGCCATGCGCCTCCGCCGCCTAGCGCTGTTCCCGGG
TGTGGCGCTGCTTCTTGCCGCGGCCCGCCTCGCCGCTGCCTCCGACGTGCTAGAACTCACGGACGACAACTTCGAGAGTCGCATCTCCGA
CACGGGCTCTGCGGGCCTCATGCTCGTCGAGTTCTTCGCCCCCTGGTGTGGACACTGCAAGAGACTTGCACCTGAGTATGAAGCTGCAGC
TACCAGATTAAAAGGAATAGTCCCATTAGCAAAGGTTGATTGCACTGCCAACACTAACACCTGTAATAAATATGGAGTCAGTGGATATCC
AACCCTGAAGATATTTAGAGATGGTGAAGAAGCAGGTGCTTATGATGGACCTAGGACTGCTGATGGAATTGTCAGCCACTTGAAGAAGCA
GGCAGGACCAGCTTCAGTGCCTCTCAGGACTGAGGAAGAATTTAAGAAATTCATTAGTGATAAAGATGCCTCTATAGTAGGTTTTTTCGA
TGATTCATTCAGTGAGGCTCACTCCGAGTTCCTAAAAGCAGCCAGCAACTTGAGGGATAACTACCGATTTGCACATACGAATGTTGAGTC
TCTGGTGAACGAGTATGATGATAATGGAGAGGGTATCATCTTATTTCGTCCTTCACATCTCACTAACAAGTTTGAGGACAAGACTGTGGC
ATATACAGAGCAAAAAATGACCAGTGGCAAAATTAAAAAGTTTATCCAGGAAAACATTTTTGGTATCTGCCCTCACATGACAGAAGACAA
TAAAGATTTGATACAGGGCAAGGACTTACTTATTGCTTACTATGATGTGGACTATGAAAAGAACGCTAAAGGTTCCAACTACTGGAGAAA
CAGGGTAATGATGGTGGCAAAGAAATTCCTGGATGCTGGGCACAAACTCAACTTTGCTGTAGCTAGCCGCAAAACCTTTAGCCATGAACT
TTCTGATTTTGGCTTGGAGAGCACTGCTGGAGAGATTCCTGTTGTTGCTATCAGAACTGCTAAAGGAGAGAAGTTTGTCATGCAGGAGGA
GTTCTCAGACCTTGTACACAGACAGACGGCTAGTGCAGTGGTACAGCACATGTCACTTGGGGTTTATGGATTTGGTTGTGAAGATTCGCT
GAATCACTTGTTGAACTATGTATGGCCCAATGTATTTGAGACATCTCCTCATGTAATTCAGGCAGTTATGGGAGCCCTAGAGGGCCTGAG
AGTTGCTATTGGACCATGTAGAATGTTGCAATATTGTTTACAGGGTCTGTTTCACCCAGCCCGGAAAGTCAGAGATGTATATTGGAAAAT
TTACAACTCCATCTACATTGGTTCCCAGGACGCTCTCATAGCACATTACCCAAGAATCTACAACGATGATAAGAACACCTATATTCGTTA
TGAACTTGACTATATCTTATAATTTTATTGTTTATTTTGTGTTTAATGCACAGCTACTTCACACCTTAAACTTGCTTTGATTTGGTGATG
TAAACTTTTAAACATTGCAGATCAGTGTAGAACTGGTCATAGAGGAAGAGCTAGAAATCCAGTAGCATGATTTTTAAATAACCTGTCTTT
GTTTTTGATGTTAAACAGTAAATGCCAGTAGTGACCAAGAACACAGTGATTATATACACTATACTGGAGGGATTTCATTTTTAATTCATC
TTTATGAAGATTTAGAACTCATTCCTTGTGTTTAAAGGGAATGTTTAATTGAGAAATAAACATTTGTGTACAAAATGCTAATTTGTGTGT
GTTTTTTGAACATGACTTGTAAAATGCGGAACTTTGATAAAGTATTGGTTTATGTGGAATAAGTGGCTTAATTTCATTTTCTGTCACATG
GTTTATAGAAAGTAGTTAGCTGAATAAAAACTATATAAAGTGATGGCATCTTTGTCAAAATTCCATTGTTGTGTTAATAATGACAGCAAG
AAGAGTAGCCTCAGGGGATGTTCCCCTCAAACTAGCACAACCATTCCATCATCGTAGAAAAGTAGCACTTTTGCTAAACTGTCTTGAATA
TTTTGTACTTACATAGCGCCTTTCATCTCTTGATTTCTCAAAATGCTTTATGAACACATTTAAAGAAAGTGGTTTAAGTCTTGTCCAACA
CTTGACAGGTCTGCTGTGTTTAGCAAGTGAGGAATTTAACTTTACTTCAAAACTGCTTTCTGCCTATTAGGAGTGAGGATACCTAAGTAA
TGCTGATAGAACAGGACAATGTTGGGCTTTTCTCCATGTTATAAGCCACTACTCAGCAATGCATCAGTAAATACCTATTCACCCACTGTA
TGCCAGCCACTGTGCTTATATGCAGGGGATGCAAAGGTGCATGAGACCTGCCCTCTACCTTTAAGAACAGTATAATGGAGAAGGGGAGAC
AAACCTTGTGACAGATTCCTTATGTACTGTGATAATACACAGTGGCAGCAGCTAAAATGTCTAGGTTTGCTTAGCTTTGTATTCAGTAAT
AATAAGTTGATCTAAGAGTTCAGCATAAACTGAATGAAATGCCATTTAATGGTAGAGGAACCAAGCATTAAGGCAGTACTACACTTAATT
TTTTAAGCAAATATGTAAAGTATATTTTCAAACTTTTCTAATGTTATGGCCCCAAATTTCTTAGTTTTGGCCTTTTTACTACCTATACTA
TTTTTACTGTTTTGTTTTGTCTCCATGTGGTAGTACTTCTGTGAACTCTAAAGGGAAAAAAAATTCTGCAAGCAGCATTAGTATATAACT
ACTACTGTAAGTAAAACTGCCTATTGACACTTTAGGAGTTCCTGCTTCAGAAGCTTAGTTAAGAAACAGCTTGTGGCCGGGTGTGGTGGC
TCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACGCGGTGAAGT
CCCGTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATGGCT
TGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATAGCGCTGCTACACTCCAGCCTGGGCGACAGAGACTCCGTCTCAAAAAAAAAAAA
AAAATTGACTTTCAACAAATTGATAGTGAGCATTAAGGGTTTCCAAGTTGGATTTGTAACTCCTCATCATTCCTTGTATGACAACTTTCT
GAATATATGTCACTATGTAGTAAAATTAAACACTCCAAACTCATCTTTCTGTTGTTAGAAGTTTTCAGCGGTACTTCCATGCAACTTTAA
ATCTCACTGCTCTCTATGGTTGATGTCAAATGACCTTCAGTAATGACTGAGAATTGAATACAAATAGATTACAAAGCCAAAATTTGATGT
TAAATGACTCAGGAAATTTTAGTTGTATTTTCAATTCAAGTACTTAGTAGCCTACGTTTGCTTGGCCTCTGGTTCTTTATGGAAAATAGG
CTTTGTAGTGGCATTGTGGAGCAAAGGAGACTGTTACACCTTAATTAACTTTTTTTACTGATGCAAATAATTTGAGGATAGAGAGGAGGG
AAGTAGTGAAAGCTATGACCTAAAACATTGGGACCAAATAGAGGCTCACAGATATTTGGATTATTTTATGTGCTTATTATTAAATAAGGA
AAGCATTTTGTGATATGTGGAAGACGCTATGTGAAGTTTTACCTATCTTCTCAAAGACCTTTTCTTTTGTATTTTCTTTTGGTGTTTCTT
AAAGCCAAACAAAGAAATGTTCTTAAGGAGACAGGGTGGGTTTTTCTGTGGGCCTTTGTTGGTTTTTCTGTGGGCCATCGCCCTCTAATG
GAATTGATCTCTGGCTGTTTGATTTTTTTCATATTGTATTTTTAAAATTTGTTGTACAGTGCCCTGTGAGCACCAAGTACCACTAGATGA

>63894_63894_1_PDIA3-SF3B1_PDIA3_chr15_44059108_ENST00000300289_SF3B1_chr2_198257912_ENST00000335508_length(amino acids)=514AA_BP=390
MGVGTSGCRSAWARRASASSGLVVARPTSAVPAEPRPFRPSPPHLAAMRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTG
SAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAG
PASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYT
EQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSD
FGLESTAGEIPVVAIRTAKGEKFVMQEEFSDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVA

--------------------------------------------------------------
>63894_63894_2_PDIA3-SF3B1_PDIA3_chr15_44059108_ENST00000538521_SF3B1_chr2_198257912_ENST00000335508_length(transcript)=4185nt_BP=1290nt
AGCAGCGGGTTAGTGGTCGCGCGCCCGACCTCCGCAGTCCCAGCCGAGCCGCGACCCTTCCGGCCGTCCCCACCCCACCTCGCCGCCATG
CGCCTCCGCCGCCTAGCGCTGTTCCCGGGTGTGGCGCTGCTTCTTGCCGCGGCCCGCCTCGCCGCTGCCTCCGACGTGCTAGAACTCACG
GACGACAACTTCGAGAGTCGCATCTCCGACACGGGCTCTGCGGGCCTCATGCTCGTCGAGTTCTTCGCCCCCTGTTCCATTCCTGCTGGA
TTTGAAGAGGAGAGTCTCCTCCAGCCTCATTGAAACTCTTTTTGTGGATTTGATGACCTTATGGATATTGCCAAAGTTTAAGGCAGTGGA
TTTTAGTCCCAGCCTTGCAGCTTACACACACACCTGGTTGCTCCCCAGATTTCTGGAGATTCTCATTCAGTGTGGACACTGCAAGAGACT
TGCACCTGAGTATGAAGCTGCAGCTACCAGATTAAAAGGAATAGTCCCATTAGCAAAGGTTGATTGCACTGCCAACACTAACACCTGTAA
TAAATATGGAGTCAGTGGATATCCAACCCTGAAGATATTTAGAGATGGTGAAGAAGCAGGTGCTTATGATGGACCTAGGACTGCTGATGG
AATTGTCAGCCACTTGAAGAAGCAGGCAGGACCAGCTTCAGTGCCTCTCAGGACTGAGGAAGAATTTAAGAAATTCATTAGTGATAAAGA
TGCCTCTATAGTAGGTTTTTTCGATGATTCATTCAGTGAGGCTCACTCCGAGTTCCTAAAAGCAGCCAGCAACTTGAGGGATAACTACCG
ATTTGCACATACGAATGTTGAGTCTCTGGTGAACGAGTATGATGATAATGGAGAGGGTATCATCTTATTTCGTCCTTCACATCTCACTAA
CAAGTTTGAGGACAAGACTGTGGCATATACAGAGCAAAAAATGACCAGTGGCAAAATTAAAAAGTTTATCCAGGAAAACATTTTTGGTAT
CTGCCCTCACATGACAGAAGACAATAAAGATTTGATACAGGGCAAGGACTTACTTATTGCTTACTATGATGTGGACTATGAAAAGAACGC
TAAAGGTTCCAACTACTGGAGAAACAGGGTAATGATGGTGGCAAAGAAATTCCTGGATGCTGGGCACAAACTCAACTTTGCTGTAGCTAG
CCGCAAAACCTTTAGCCATGAACTTTCTGATTTTGGCTTGGAGAGCACTGCTGGAGAGATTCCTGTTGTTGCTATCAGAACTGCTAAAGG
AGAGAAGTTTGTCATGCAGGAGGAGTTCTCAGACCTTGTACACAGACAGACGGCTAGTGCAGTGGTACAGCACATGTCACTTGGGGTTTA
TGGATTTGGTTGTGAAGATTCGCTGAATCACTTGTTGAACTATGTATGGCCCAATGTATTTGAGACATCTCCTCATGTAATTCAGGCAGT
TATGGGAGCCCTAGAGGGCCTGAGAGTTGCTATTGGACCATGTAGAATGTTGCAATATTGTTTACAGGGTCTGTTTCACCCAGCCCGGAA
AGTCAGAGATGTATATTGGAAAATTTACAACTCCATCTACATTGGTTCCCAGGACGCTCTCATAGCACATTACCCAAGAATCTACAACGA
TGATAAGAACACCTATATTCGTTATGAACTTGACTATATCTTATAATTTTATTGTTTATTTTGTGTTTAATGCACAGCTACTTCACACCT
TAAACTTGCTTTGATTTGGTGATGTAAACTTTTAAACATTGCAGATCAGTGTAGAACTGGTCATAGAGGAAGAGCTAGAAATCCAGTAGC
ATGATTTTTAAATAACCTGTCTTTGTTTTTGATGTTAAACAGTAAATGCCAGTAGTGACCAAGAACACAGTGATTATATACACTATACTG
GAGGGATTTCATTTTTAATTCATCTTTATGAAGATTTAGAACTCATTCCTTGTGTTTAAAGGGAATGTTTAATTGAGAAATAAACATTTG
TGTACAAAATGCTAATTTGTGTGTGTTTTTTGAACATGACTTGTAAAATGCGGAACTTTGATAAAGTATTGGTTTATGTGGAATAAGTGG
CTTAATTTCATTTTCTGTCACATGGTTTATAGAAAGTAGTTAGCTGAATAAAAACTATATAAAGTGATGGCATCTTTGTCAAAATTCCAT
TGTTGTGTTAATAATGACAGCAAGAAGAGTAGCCTCAGGGGATGTTCCCCTCAAACTAGCACAACCATTCCATCATCGTAGAAAAGTAGC
ACTTTTGCTAAACTGTCTTGAATATTTTGTACTTACATAGCGCCTTTCATCTCTTGATTTCTCAAAATGCTTTATGAACACATTTAAAGA
AAGTGGTTTAAGTCTTGTCCAACACTTGACAGGTCTGCTGTGTTTAGCAAGTGAGGAATTTAACTTTACTTCAAAACTGCTTTCTGCCTA
TTAGGAGTGAGGATACCTAAGTAATGCTGATAGAACAGGACAATGTTGGGCTTTTCTCCATGTTATAAGCCACTACTCAGCAATGCATCA
GTAAATACCTATTCACCCACTGTATGCCAGCCACTGTGCTTATATGCAGGGGATGCAAAGGTGCATGAGACCTGCCCTCTACCTTTAAGA
ACAGTATAATGGAGAAGGGGAGACAAACCTTGTGACAGATTCCTTATGTACTGTGATAATACACAGTGGCAGCAGCTAAAATGTCTAGGT
TTGCTTAGCTTTGTATTCAGTAATAATAAGTTGATCTAAGAGTTCAGCATAAACTGAATGAAATGCCATTTAATGGTAGAGGAACCAAGC
ATTAAGGCAGTACTACACTTAATTTTTTAAGCAAATATGTAAAGTATATTTTCAAACTTTTCTAATGTTATGGCCCCAAATTTCTTAGTT
TTGGCCTTTTTACTACCTATACTATTTTTACTGTTTTGTTTTGTCTCCATGTGGTAGTACTTCTGTGAACTCTAAAGGGAAAAAAAATTC
TGCAAGCAGCATTAGTATATAACTACTACTGTAAGTAAAACTGCCTATTGACACTTTAGGAGTTCCTGCTTCAGAAGCTTAGTTAAGAAA
CAGCTTGTGGCCGGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGA
CCATCCTGGCTAACGCGGTGAAGTCCCGTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTAG
GGAGGCTGAGGCAGGAGAATGGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATAGCGCTGCTACACTCCAGCCTGGGCGACAG
AGACTCCGTCTCAAAAAAAAAAAAAAAATTGACTTTCAACAAATTGATAGTGAGCATTAAGGGTTTCCAAGTTGGATTTGTAACTCCTCA
TCATTCCTTGTATGACAACTTTCTGAATATATGTCACTATGTAGTAAAATTAAACACTCCAAACTCATCTTTCTGTTGTTAGAAGTTTTC
AGCGGTACTTCCATGCAACTTTAAATCTCACTGCTCTCTATGGTTGATGTCAAATGACCTTCAGTAATGACTGAGAATTGAATACAAATA
GATTACAAAGCCAAAATTTGATGTTAAATGACTCAGGAAATTTTAGTTGTATTTTCAATTCAAGTACTTAGTAGCCTACGTTTGCTTGGC
CTCTGGTTCTTTATGGAAAATAGGCTTTGTAGTGGCATTGTGGAGCAAAGGAGACTGTTACACCTTAATTAACTTTTTTTACTGATGCAA
ATAATTTGAGGATAGAGAGGAGGGAAGTAGTGAAAGCTATGACCTAAAACATTGGGACCAAATAGAGGCTCACAGATATTTGGATTATTT
TATGTGCTTATTATTAAATAAGGAAAGCATTTTGTGATATGTGGAAGACGCTATGTGAAGTTTTACCTATCTTCTCAAAGACCTTTTCTT
TTGTATTTTCTTTTGGTGTTTCTTAAAGCCAAACAAAGAAATGTTCTTAAGGAGACAGGGTGGGTTTTTCTGTGGGCCTTTGTTGGTTTT
TCTGTGGGCCATCGCCCTCTAATGGAATTGATCTCTGGCTGTTTGATTTTTTTCATATTGTATTTTTAAAATTTGTTGTACAGTGCCCTG

>63894_63894_2_PDIA3-SF3B1_PDIA3_chr15_44059108_ENST00000538521_SF3B1_chr2_198257912_ENST00000335508_length(amino acids)=482AA_BP=358
MRASCSSSSSPPVPFLLDLKRRVSSSLIETLFVDLMTLWILPKFKAVDFSPSLAAYTHTWLLPRFLEILIQCGHCKRLAPEYEAAATRLK
GIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFS
EAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLI
QGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSDL
VHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSI

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Fusion Gene PPI Analysis for PDIA3-SF3B1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000409915		0	7	1156_1157	0	88.0	PHF5A
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000409915		0	7	547_550	0	88.0	PHF5A
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000414963		0	5	1156_1157	0	145.0	PHF5A
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000414963		0	5	547_550	0	145.0	PHF5A
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000409915		0	7	223_491	0	88.0	PPP1R8
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000414963		0	5	223_491	0	145.0	PPP1R8
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000409915		0	7	529_568	0	88.0	SF3B14
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000414963		0	5	529_568	0	145.0	SF3B14
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000335508		22	25	1248_1304	1179.6666666666667	1305.0	SF3B3 and SF3B5
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000409915		0	7	1248_1304	0	88.0	SF3B3 and SF3B5
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000414963		0	5	1248_1304	0	145.0	SF3B3 and SF3B5

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000335508		22	25	1156_1157	1179.6666666666667	1305.0	PHF5A
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000335508		22	25	547_550	1179.6666666666667	1305.0	PHF5A
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000335508		22	25	223_491	1179.6666666666667	1305.0	PPP1R8
Tgene	SF3B1	chr15:44059108	chr2:198257912	ENST00000335508		22	25	529_568	1179.6666666666667	1305.0	SF3B14

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PDIA3-SF3B1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PDIA3-SF3B1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source