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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDSS2-DCLK1 (FusionGDB2 ID:64082)

Fusion Gene Summary for PDSS2-DCLK1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDSS2-DCLK1
Fusion gene ID: 64082
HgeneTgene
Gene symbol

PDSS2

DCLK1

Gene ID

57107

9201

Gene namedecaprenyl diphosphate synthase subunit 2doublecortin like kinase 1
SynonymsC6orf210|COQ10D3|COQ1B|DLP1|bA59I9.3|hDLP1CL1|CLICK1|DCAMKL1|DCDC3A|DCLK
Cytomap

6q21

13q13.3

Type of geneprotein-codingprotein-coding
Descriptiondecaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decaprserine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1
Modification date2020031320200320
UniProtAcc.

O15075

Ensembl transtripts involved in fusion geneENST00000369031, ENST00000369037, 
ENST00000453874, 		ENST00000379892, 
ENST00000379893, ENST00000460982, 
ENST00000255448, ENST00000360631, 
Fusion gene scores* DoF score11 X 8 X 6=52810 X 9 X 7=630
# samples 1310
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDSS2 [Title/Abstract] AND DCLK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDSS2(107595233)-DCLK1(36413313), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDSS2

GO:0006744

ubiquinone biosynthetic process

16262699

HgenePDSS2

GO:0008299

isoprenoid biosynthetic process

16262699


check buttonFusion gene breakpoints across PDSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCLK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5415-01APDSS2chr6

107595233

-DCLK1chr13

36413313

-


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Fusion Gene ORF analysis for PDSS2-DCLK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000369031ENST00000379892PDSS2chr6

107595233

-DCLK1chr13

36413313

-
5CDS-intronENST00000369031ENST00000379893PDSS2chr6

107595233

-DCLK1chr13

36413313

-
5CDS-intronENST00000369031ENST00000460982PDSS2chr6

107595233

-DCLK1chr13

36413313

-
5CDS-intronENST00000369037ENST00000379892PDSS2chr6

107595233

-DCLK1chr13

36413313

-
5CDS-intronENST00000369037ENST00000379893PDSS2chr6

107595233

-DCLK1chr13

36413313

-
5CDS-intronENST00000369037ENST00000460982PDSS2chr6

107595233

-DCLK1chr13

36413313

-
5CDS-intronENST00000453874ENST00000379892PDSS2chr6

107595233

-DCLK1chr13

36413313

-
5CDS-intronENST00000453874ENST00000379893PDSS2chr6

107595233

-DCLK1chr13

36413313

-
5CDS-intronENST00000453874ENST00000460982PDSS2chr6

107595233

-DCLK1chr13

36413313

-
In-frameENST00000369031ENST00000255448PDSS2chr6

107595233

-DCLK1chr13

36413313

-
In-frameENST00000369031ENST00000360631PDSS2chr6

107595233

-DCLK1chr13

36413313

-
In-frameENST00000369037ENST00000255448PDSS2chr6

107595233

-DCLK1chr13

36413313

-
In-frameENST00000369037ENST00000360631PDSS2chr6

107595233

-DCLK1chr13

36413313

-
In-frameENST00000453874ENST00000255448PDSS2chr6

107595233

-DCLK1chr13

36413313

-
In-frameENST00000453874ENST00000360631PDSS2chr6

107595233

-DCLK1chr13

36413313

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369037PDSS2chr6107595233-ENST00000360631DCLK1chr1336413313-52909082092095628
ENST00000369037PDSS2chr6107595233-ENST00000255448DCLK1chr1336413313-53649082092062617
ENST00000453874PDSS2chr6107595233-ENST00000360631DCLK1chr1336413313-52839012022088628
ENST00000453874PDSS2chr6107595233-ENST00000255448DCLK1chr1336413313-53579012022055617
ENST00000369031PDSS2chr6107595233-ENST00000360631DCLK1chr1336413313-52919092102096628
ENST00000369031PDSS2chr6107595233-ENST00000255448DCLK1chr1336413313-53659092102063617

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369037ENST00000360631PDSS2chr6107595233-DCLK1chr1336413313-0.0008464520.9991535
ENST00000369037ENST00000255448PDSS2chr6107595233-DCLK1chr1336413313-0.0008402970.9991597
ENST00000453874ENST00000360631PDSS2chr6107595233-DCLK1chr1336413313-0.0008455430.99915445
ENST00000453874ENST00000255448PDSS2chr6107595233-DCLK1chr1336413313-0.0008395820.9991604
ENST00000369031ENST00000360631PDSS2chr6107595233-DCLK1chr1336413313-0.0008526670.9991473
ENST00000369031ENST00000255448PDSS2chr6107595233-DCLK1chr1336413313-0.0008464980.9991535

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Fusion Genomic Features for PDSS2-DCLK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDSS2-DCLK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:107595233/chr13:36413313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DCLK1

O15075

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDCLK1chr6:107595233chr13:36413313ENST00000255448518698_701345730.0Compositional biasNote=Poly-Arg
TgeneDCLK1chr6:107595233chr13:36413313ENST00000360631517698_701345741.0Compositional biasNote=Poly-Arg
TgeneDCLK1chr6:107595233chr13:36413313ENST00000379893113288_34038434.0Compositional biasNote=Pro/Ser-rich
TgeneDCLK1chr6:107595233chr13:36413313ENST00000379893113698_70138434.0Compositional biasNote=Poly-Arg
TgeneDCLK1chr6:107595233chr13:36413313ENST00000255448518390_647345730.0DomainProtein kinase
TgeneDCLK1chr6:107595233chr13:36413313ENST00000360631517390_647345741.0DomainProtein kinase
TgeneDCLK1chr6:107595233chr13:36413313ENST00000379893113186_26938434.0DomainDoublecortin 2
TgeneDCLK1chr6:107595233chr13:36413313ENST00000379893113390_64738434.0DomainProtein kinase
TgeneDCLK1chr6:107595233chr13:36413313ENST0000037989311357_14338434.0DomainDoublecortin 1
TgeneDCLK1chr6:107595233chr13:36413313ENST00000255448518396_404345730.0Nucleotide bindingATP
TgeneDCLK1chr6:107595233chr13:36413313ENST00000360631517396_404345741.0Nucleotide bindingATP
TgeneDCLK1chr6:107595233chr13:36413313ENST00000379893113396_40438434.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDCLK1chr6:107595233chr13:36413313ENST00000255448518288_340345730.0Compositional biasNote=Pro/Ser-rich
TgeneDCLK1chr6:107595233chr13:36413313ENST00000360631517288_340345741.0Compositional biasNote=Pro/Ser-rich
TgeneDCLK1chr6:107595233chr13:36413313ENST00000255448518186_269345730.0DomainDoublecortin 2
TgeneDCLK1chr6:107595233chr13:36413313ENST0000025544851857_143345730.0DomainDoublecortin 1
TgeneDCLK1chr6:107595233chr13:36413313ENST00000360631517186_269345741.0DomainDoublecortin 2
TgeneDCLK1chr6:107595233chr13:36413313ENST0000036063151757_143345741.0DomainDoublecortin 1


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Fusion Gene Sequence for PDSS2-DCLK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64082_64082_1_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000369031_DCLK1_chr13_36413313_ENST00000255448_length(transcript)=5365nt_BP=909nt
ATGCCTCCAATATGGCGTCCTCCACATAGGCAGTGGCTGTGGTTTCTACCCCGGGTGGCCGGGGGCAGTGCTGAGCTGGGACTGTTGTTT
GCCCAGCCTGGGCTGCAGAAAGCAGCAGTTAAAGTTCGTTTCTGGTCACTGCTCCAGGAAGCCACCTTACTCTGAGGGTCAAGAATTGCC
GCTTCCTTTTAGTTACTGTAAGTTCCTCCTCTGCCCCTGGTTTGTTTCCCGCGGCACTTCTGGATACCCCCAGGTCCCAGACCCTTCCAG
ACTCAAACCATGAACTTTCGGCAGCTGCTGTTGCACTTGCCACGTTATCTTGGAGCCTCGGGTTCCCCGCGTCGCCTGTGGTGGTCCCCG
TCCCTCGACACCATCTCCTCGGTGGGCTCTTGGCGTGGTCGGTCCTCCAAGTCCCCGGCCCACTGGAATCAGGTAGTGTCAGAGGCGGAG
AAGATCGTGGGGTACCCCACGTCCTTCATGAGCCTTCGCTGCCTGCTGAGCGACGAGCTCAGCAACATCGCTATGCAGGTGCGGAAGCTG
GTGGGCACTCAGCACCCTCTGCTTACCACAGCCAGGGGGCTTGTACATGACAGCTGGAATAGCCTCCAGTTGAGGGGCTTGGTGGTGCTC
CTTATCTCTAAAGCAGCTGGGCCCAGCAGCGTGAACACTTCATGTCAGAACTATGACATGGTCAGTGGGATCTACTCATGTCAAAGAAGT
TTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCA
CTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAG
AACACCAAGAGCTCTCAGCATGGCGGCTCCTCTACGTCACTTGCGTCCACCAAAGTCTGCAGCTCGATGGATGAGAACGATGGCCCTGGA
GAAGAAGTGTCGGAGGAAGGCTTCCAGATTCCAGCTACAATAACAGAACGATATAAAGTCGGAAGAACAATAGGAGATGGAAATTTTGCT
GTTGTCAAGGAATGTGTAGAAAGATCGACTGCTAGAGAGTATGCTCTGAAAATTATCAAGAAAAGCAAATGTCGAGGCAAAGAGCACATG
ATCCAGAATGAAGTGTCTATTTTAAGAAGAGTGAAGCATCCCAATATCGTTCTTCTGATTGAGGAGATGGATGTGCCAACTGAACTGTAT
CTTGTCATGGAATTAGTAAAGGGGGGAGACCTTTTTGATGCCATTACTTCCACTAACAAATACACCGAGAGAGACGCCAGTGGGATGCTG
TACAACCTAGCCAGCGCCATCAAATACCTGCATAGCCTGAACATCGTCCACCGTGATATCAAGCCAGAGAACCTGCTGGTGTATGAGCAC
CAAGATGGCAGCAAATCACTGAAGCTGGGTGACTTTGGACTGGCCACCATTGTAGACGGCCCCCTGTACACAGTCTGTGGCACCCCAACA
TACGTGGCTCCAGAAATCATTGCAGAGACTGGATACGGCCTCAAGGTGGACATCTGGGCAGCAGGTGTAATCACTTATATCCTGCTGTGT
GGTTTCCCTCCATTCCGTGGAAGTGGTGATGACCAGGAGGTGCTTTTTGATCAGATTTTGATGGGGCAGGTGGACTTTCCTTCTCCATAC
TGGGATAATGTTTCCGATTCTGCAAAGGAGCTCATTACCATGATGCTGTTGGTCGATGTAGATCAGCGATTTTCTGCTGTTCAAGTACTT
GAGCATCCCTGGGTTAATGATGATGGCCTCCCAGAAAATGAACATCAGCTGTCAGTAGCTGGAAAGATAAAGAAGCATTTCAACACAGGC
CCCAAGCCGAATAGCACAGCAGCTGGAGTTTCTGTCATAGCACTGGACCACGGGTTTACCATCAAGAGATCAGGGTCTTTGGACTACTAC
CAGCAACCAGGAATGTATTGGATAAGACCACCGCTCTTGATAAGGAGAGGCAGGTTTTCCGACGAAGACGCAACCAGGATGTGAGGAGCC
GGTACAAGGCGCAGCCAGCTCCTCCCGAACTCAACTCGGAATCGGAAGACTACTCCCCAAGCTCCTCCGAGACTGTTCGCTCCCCTAACT
CGCCCTTTTAATAAGACCCTTTTACTCAAAGTCCTAGCTTAACCCTTTGAGACTCTGAGATTTTTTTCCCCCAAATTTGTGTAAAACAGT
TTCATCTGATCTATCTAGCGCTCAATGCTTGAATGGCAGAACTGAAAGTGTTTTCAGGTATCTTTGTAGCGGTTTCCCTTTACTGAATAA
GATGACACGTGGTGATTGTGAAGATGGTAATTTGCTGCTAATAGAGTCCTCAAAGGGTTAAGGCCAATTTGCAATTTTTTTTTAAACTTA
GAAGCAATGAATGTTTTCATCAGTCAAGCTAGGATCTGCAGTATGTAATATAGCACTTGTTAACCCTCTGAGTGCATAGAATTTTATTGA
GAATTCTTGTTTGGGAATTTTTCAGGCCTTTGGATGTATACACACATGTTTCTTGATTTTACTGCAGATCAAGGGGTGTTGTTAGATGCT
GAAATGTCCAGAAAAGAAGGACATTTAGAATGATATCTTGTTTGTCCTTTTCTGTGGGTTTAGAACGTGGCAGGTTTATAACTTCGACAC
ACGCACGGTTCTTTCTTCTTCACAATCCTATTCAGAAACAGATTTTTTTTTTCATTAGAGATATGACTGTCAGTTGCAGTGAGTTCTGCA
TCCCAAGTGGAGGGAATTGGGTTTGTGGCAAAGAGCTTGACCCAGGAAATAGATGGTGCCCCCCAAATTGTCTCCACATGAAGATGTACT
GATGACGCCCCAGAAATGCTGCTTCCATATCAGCTGCTGCTAGCGCCAGCGCAGACTCTCAGGGAGTCACCACAGCTTGTCTTGTGCTTG
GTGAGTGAGGGTCTCTCTACTCAGTGTCAGACATCTACAGGAAAGAAACAACTGGTGGAAAAGAGCAATAAATTGCCCGGTGCTCTGCAG
GGCTGGAATTTCAAACAGAAAGAGGGAATAAGATCCTGTGATTTTTCTCACCTGCTTTTCCACGCACTGTGGTCATCACTGTGCAATCTA
CATCTAGTATGAAATCCACACATAGGAGAGCTGGGGCACAAGGGGACTGGAGGCAGTTGCTTTGCAAGATGGCTGAGGAGAAAGCACACT
GGGAACACAATCCAGAATGTTCTAACAATAAGTTTTCAGTGAATAAACCACTGGCAAGACAATTCCATGTGCACCTTTAGGTTACCTATA
TAGTCTCCTAGGAAGATCAGGATGAAAGACCTAGATGATACCCCTGAGGATAAAACCTCCATCCCCTAAAATGATTTTTTTTAAATACCA
CTGTCTTTAGCTGTCCAGGAGGTCAGAGTGTTTTTTCTGTCTTTGGGCCAAGTCCTGTCTGAGACCTGTATTTTCACTCTTGTTACCAAA
TCTATCTCCCTAGTGCAGTGTCTCCAGGCCTGAGTTTCTTCTGGAACAGATTCCATTTTAGAATGGGGATTCACAGGTTCTGTGCATCAC
CACAGTGCTCAGAGAGGATTCTCCTGGGGTGTCTTAGAGGCAGGTGCCCAACTCAAATGTATTCCCAAGGTTTGCTGGGCTCTGGGATCC
ACGAGACAACCAGAGAGGGATATCTCATGAAATTTGCATCTGGTGGCTGAACAGTACCTATGTTCTCTGTTTTGAATATACTTTAATACC
TGAGAGTCTTAAAATTTGTGAACAACGTTTCTATAGTCCTTTATTTTCAAATGCACATTGATCTTCACTTGCTGCATTTTTACTCTTCAA
CCCTGAAACTATGGTCTACATTAATATGGATTTTTAAATCACATGTCATTACTTTTGCAACACCATCACCAAAATTTTTTGCTCTTTTAC
ATTTAGGTTCATCTCTGTGGTCTGTGTTGTCCTGACATGTAAAAAGCATATCGTTTATTGAGGTTTTTTTCCCCCCCTTTTAGAGCATCC
GGAAGTGATAACACGCAAAATCACAAAGTAGCATAAATCAGTAAATTAGTTGAGTTGTTTTTGGGGGGGAGGTGGGGGTAGGGGGCACAG
AACACCAGAAAGAGTGTTGGTGTGTAGGTAGATTCCATATTAATGAGGAACACTGAACTAGTTGGAAATTACTGCTTTCTCTAGAAATAT
AAAGCAAAGCACTATTCCAAGGCTATGGAGTAGCTCTACAGCCTGGCCTCAACTCTAAAAGTGTGAAGAATGCAATGGGCAGAGACCTAC
CTGCAGTGGACTGTCATTTTCCTTTCTTTCTCTGAATTACTGCTTTTTCTGTGGGCATTAACTATATTGCTACAGCATCTAGTGTACTGA
GCCTGCGGTGCATGGCTCAGGCCTTTTCCCATCGACGTCTAGGGGGACTCTGGACCGTGTGAAGCTAGGGGGTGTTTCTCAGCACACTGC
AGAAGGGCAGCTCAGAAGAATGCAGGGCCCATTCAGCATGGGGATCCCAGCACATCACTGTAGAATTTGAGTGATCTATGCTGAATAAAC
AGTGGAATGTGACCAGTCAAGTAGAAATCTTGAGTAATCAGATGGAATGCAATCTTTCTAACATTAAGCTACCAAGATCCTGAATGTCAG
AGATGTACTCAGAGGGTTAACAGACAAGCACAAGGCATGCTGACTACATTGGTGTATCCAGATTGCTTTGCTTTTAGCCAGTGCTTTCTA
ATTTTTTTCTCGACATTCTTGGGATAGTTCAAGTTTGAAATAATTAAGTGGTGGTGTTCTTTAAGGAATTTCTATAACCAAATTGATCTT
ATTTTTGATTTCACTTATCATAGAACAAATATGTATCATTATGGCAGTGTATCTATGTAATTATCAATTTAATCATCACCACCGGTGTTT
CCATATTTTTTCCCAAGTATTTAATATAGCTCTCTTATGGTGGTGGCCTGGTGATGGGGACCGTCTTTCTTTTACTGACACATGACCAAT
CATATGGTATTTTCAAGGGAATTTTAAGATTCATCTTTTCAGTTTGATAGTAGACTAGTTAAGGAAGAACTCTTTCATTACTTGCATCGT
GTAAATCATCTCTGTAGACATGTGTTCATATTAATGAACACATTTTTTCTCAACATTGTAGCAGAAATCATTTTATTCGTCATGATCAAT
GAATATGTGATTTGCTCCAGATCGTTAGAAGGAAAAGTAAGATTTCAGTCATCAAAAATGTTTTTACCGTAGCCCTCATCTAACTTACAC

>64082_64082_1_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000369031_DCLK1_chr13_36413313_ENST00000255448_length(amino acids)=617AA_BP=233
MPLVCFPRHFWIPPGPRPFQTQTMNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSKSPAHWNQVVSEAEKIVGYPTSFM
SLRCLLSDELSNIAMQVRKLVGTQHPLLTTARGLVHDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHI
ALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQI
PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGD
LFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAET
GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGL

--------------------------------------------------------------
>64082_64082_2_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000369031_DCLK1_chr13_36413313_ENST00000360631_length(transcript)=5291nt_BP=909nt
ATGCCTCCAATATGGCGTCCTCCACATAGGCAGTGGCTGTGGTTTCTACCCCGGGTGGCCGGGGGCAGTGCTGAGCTGGGACTGTTGTTT
GCCCAGCCTGGGCTGCAGAAAGCAGCAGTTAAAGTTCGTTTCTGGTCACTGCTCCAGGAAGCCACCTTACTCTGAGGGTCAAGAATTGCC
GCTTCCTTTTAGTTACTGTAAGTTCCTCCTCTGCCCCTGGTTTGTTTCCCGCGGCACTTCTGGATACCCCCAGGTCCCAGACCCTTCCAG
ACTCAAACCATGAACTTTCGGCAGCTGCTGTTGCACTTGCCACGTTATCTTGGAGCCTCGGGTTCCCCGCGTCGCCTGTGGTGGTCCCCG
TCCCTCGACACCATCTCCTCGGTGGGCTCTTGGCGTGGTCGGTCCTCCAAGTCCCCGGCCCACTGGAATCAGGTAGTGTCAGAGGCGGAG
AAGATCGTGGGGTACCCCACGTCCTTCATGAGCCTTCGCTGCCTGCTGAGCGACGAGCTCAGCAACATCGCTATGCAGGTGCGGAAGCTG
GTGGGCACTCAGCACCCTCTGCTTACCACAGCCAGGGGGCTTGTACATGACAGCTGGAATAGCCTCCAGTTGAGGGGCTTGGTGGTGCTC
CTTATCTCTAAAGCAGCTGGGCCCAGCAGCGTGAACACTTCATGTCAGAACTATGACATGGTCAGTGGGATCTACTCATGTCAAAGAAGT
TTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCA
CTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAG
AACACCAAGAGCTCTCAGCATGGCGGCTCCTCTACGTCACTTGCGTCCACCAAAGTCTGCAGCTCGATGGATGAGAACGATGGCCCTGGA
GAAGAAGTGTCGGAGGAAGGCTTCCAGATTCCAGCTACAATAACAGAACGATATAAAGTCGGAAGAACAATAGGAGATGGAAATTTTGCT
GTTGTCAAGGAATGTGTAGAAAGATCGACTGCTAGAGAGTATGCTCTGAAAATTATCAAGAAAAGCAAATGTCGAGGCAAAGAGCACATG
ATCCAGAATGAAGTGTCTATTTTAAGAAGAGTGAAGCATCCCAATATCGTTCTTCTGATTGAGGAGATGGATGTGCCAACTGAACTGTAT
CTTGTCATGGAATTAGTAAAGGGGGGAGACCTTTTTGATGCCATTACTTCCACTAACAAATACACCGAGAGAGACGCCAGTGGGATGCTG
TACAACCTAGCCAGCGCCATCAAATACCTGCATAGCCTGAACATCGTCCACCGTGATATCAAGCCAGAGAACCTGCTGGTGTATGAGCAC
CAAGATGGCAGCAAATCACTGAAGCTGGGTGACTTTGGACTGGCCACCATTGTAGACGGCCCCCTGTACACAGTCTGTGGCACCCCAACA
TACGTGGCTCCAGAAATCATTGCAGAGACTGGATACGGCCTCAAGGTGGACATCTGGGCAGCAGGTGTAATCACTTATATCCTGCTGTGT
GGTTTCCCTCCATTCCGTGGAAGTGGTGATGACCAGGAGGTGCTTTTTGATCAGATTTTGATGGGGCAGGTGGACTTTCCTTCTCCATAC
TGGGATAATGTTTCCGATTCTGCAAAGGAGCTCATTACCATGATGCTGTTGGTCGATGTAGATCAGCGATTTTCTGCTGTTCAAGTACTT
GAGCATCCCTGGGTTAATGATGATGGCCTCCCAGAAAATGAACATCAGCTGTCAGTAGCTGGAAAGATAAAGAAGCATTTCAACACAGGC
CCCAAGCCGAATAGCACAGCAGCTGGAGTTTCTGTCATAGCAACCACCGCTCTTGATAAGGAGAGGCAGGTTTTCCGACGAAGACGCAAC
CAGGATGTGAGGAGCCGGTACAAGGCGCAGCCAGCTCCTCCCGAACTCAACTCGGAATCGGAAGACTACTCCCCAAGCTCCTCCGAGACT
GTTCGCTCCCCTAACTCGCCCTTTTAATAAGACCCTTTTACTCAAAGTCCTAGCTTAACCCTTTGAGACTCTGAGATTTTTTTCCCCCAA
ATTTGTGTAAAACAGTTTCATCTGATCTATCTAGCGCTCAATGCTTGAATGGCAGAACTGAAAGTGTTTTCAGGTATCTTTGTAGCGGTT
TCCCTTTACTGAATAAGATGACACGTGGTGATTGTGAAGATGGTAATTTGCTGCTAATAGAGTCCTCAAAGGGTTAAGGCCAATTTGCAA
TTTTTTTTTAAACTTAGAAGCAATGAATGTTTTCATCAGTCAAGCTAGGATCTGCAGTATGTAATATAGCACTTGTTAACCCTCTGAGTG
CATAGAATTTTATTGAGAATTCTTGTTTGGGAATTTTTCAGGCCTTTGGATGTATACACACATGTTTCTTGATTTTACTGCAGATCAAGG
GGTGTTGTTAGATGCTGAAATGTCCAGAAAAGAAGGACATTTAGAATGATATCTTGTTTGTCCTTTTCTGTGGGTTTAGAACGTGGCAGG
TTTATAACTTCGACACACGCACGGTTCTTTCTTCTTCACAATCCTATTCAGAAACAGATTTTTTTTTTCATTAGAGATATGACTGTCAGT
TGCAGTGAGTTCTGCATCCCAAGTGGAGGGAATTGGGTTTGTGGCAAAGAGCTTGACCCAGGAAATAGATGGTGCCCCCCAAATTGTCTC
CACATGAAGATGTACTGATGACGCCCCAGAAATGCTGCTTCCATATCAGCTGCTGCTAGCGCCAGCGCAGACTCTCAGGGAGTCACCACA
GCTTGTCTTGTGCTTGGTGAGTGAGGGTCTCTCTACTCAGTGTCAGACATCTACAGGAAAGAAACAACTGGTGGAAAAGAGCAATAAATT
GCCCGGTGCTCTGCAGGGCTGGAATTTCAAACAGAAAGAGGGAATAAGATCCTGTGATTTTTCTCACCTGCTTTTCCACGCACTGTGGTC
ATCACTGTGCAATCTACATCTAGTATGAAATCCACACATAGGAGAGCTGGGGCACAAGGGGACTGGAGGCAGTTGCTTTGCAAGATGGCT
GAGGAGAAAGCACACTGGGAACACAATCCAGAATGTTCTAACAATAAGTTTTCAGTGAATAAACCACTGGCAAGACAATTCCATGTGCAC
CTTTAGGTTACCTATATAGTCTCCTAGGAAGATCAGGATGAAAGACCTAGATGATACCCCTGAGGATAAAACCTCCATCCCCTAAAATGA
TTTTTTTTAAATACCACTGTCTTTAGCTGTCCAGGAGGTCAGAGTGTTTTTTCTGTCTTTGGGCCAAGTCCTGTCTGAGACCTGTATTTT
CACTCTTGTTACCAAATCTATCTCCCTAGTGCAGTGTCTCCAGGCCTGAGTTTCTTCTGGAACAGATTCCATTTTAGAATGGGGATTCAC
AGGTTCTGTGCATCACCACAGTGCTCAGAGAGGATTCTCCTGGGGTGTCTTAGAGGCAGGTGCCCAACTCAAATGTATTCCCAAGGTTTG
CTGGGCTCTGGGATCCACGAGACAACCAGAGAGGGATATCTCATGAAATTTGCATCTGGTGGCTGAACAGTACCTATGTTCTCTGTTTTG
AATATACTTTAATACCTGAGAGTCTTAAAATTTGTGAACAACGTTTCTATAGTCCTTTATTTTCAAATGCACATTGATCTTCACTTGCTG
CATTTTTACTCTTCAACCCTGAAACTATGGTCTACATTAATATGGATTTTTAAATCACATGTCATTACTTTTGCAACACCATCACCAAAA
TTTTTTGCTCTTTTACATTTAGGTTCATCTCTGTGGTCTGTGTTGTCCTGACATGTAAAAAGCATATCGTTTATTGAGGTTTTTTTCCCC
CCCTTTTAGAGCATCCGGAAGTGATAACACGCAAAATCACAAAGTAGCATAAATCAGTAAATTAGTTGAGTTGTTTTTGGGGGGGAGGTG
GGGGTAGGGGGCACAGAACACCAGAAAGAGTGTTGGTGTGTAGGTAGATTCCATATTAATGAGGAACACTGAACTAGTTGGAAATTACTG
CTTTCTCTAGAAATATAAAGCAAAGCACTATTCCAAGGCTATGGAGTAGCTCTACAGCCTGGCCTCAACTCTAAAAGTGTGAAGAATGCA
ATGGGCAGAGACCTACCTGCAGTGGACTGTCATTTTCCTTTCTTTCTCTGAATTACTGCTTTTTCTGTGGGCATTAACTATATTGCTACA
GCATCTAGTGTACTGAGCCTGCGGTGCATGGCTCAGGCCTTTTCCCATCGACGTCTAGGGGGACTCTGGACCGTGTGAAGCTAGGGGGTG
TTTCTCAGCACACTGCAGAAGGGCAGCTCAGAAGAATGCAGGGCCCATTCAGCATGGGGATCCCAGCACATCACTGTAGAATTTGAGTGA
TCTATGCTGAATAAACAGTGGAATGTGACCAGTCAAGTAGAAATCTTGAGTAATCAGATGGAATGCAATCTTTCTAACATTAAGCTACCA
AGATCCTGAATGTCAGAGATGTACTCAGAGGGTTAACAGACAAGCACAAGGCATGCTGACTACATTGGTGTATCCAGATTGCTTTGCTTT
TAGCCAGTGCTTTCTAATTTTTTTCTCGACATTCTTGGGATAGTTCAAGTTTGAAATAATTAAGTGGTGGTGTTCTTTAAGGAATTTCTA
TAACCAAATTGATCTTATTTTTGATTTCACTTATCATAGAACAAATATGTATCATTATGGCAGTGTATCTATGTAATTATCAATTTAATC
ATCACCACCGGTGTTTCCATATTTTTTCCCAAGTATTTAATATAGCTCTCTTATGGTGGTGGCCTGGTGATGGGGACCGTCTTTCTTTTA
CTGACACATGACCAATCATATGGTATTTTCAAGGGAATTTTAAGATTCATCTTTTCAGTTTGATAGTAGACTAGTTAAGGAAGAACTCTT
TCATTACTTGCATCGTGTAAATCATCTCTGTAGACATGTGTTCATATTAATGAACACATTTTTTCTCAACATTGTAGCAGAAATCATTTT
ATTCGTCATGATCAATGAATATGTGATTTGCTCCAGATCGTTAGAAGGAAAAGTAAGATTTCAGTCATCAAAAATGTTTTTACCGTAGCC

>64082_64082_2_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000369031_DCLK1_chr13_36413313_ENST00000360631_length(amino acids)=628AA_BP=233
MPLVCFPRHFWIPPGPRPFQTQTMNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSKSPAHWNQVVSEAEKIVGYPTSFM
SLRCLLSDELSNIAMQVRKLVGTQHPLLTTARGLVHDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHI
ALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQI
PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGD
LFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAET
GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGL

--------------------------------------------------------------
>64082_64082_3_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000369037_DCLK1_chr13_36413313_ENST00000255448_length(transcript)=5364nt_BP=908nt
TGCCTCCAATATGGCGTCCTCCACATAGGCAGTGGCTGTGGTTTCTACCCCGGGTGGCCGGGGGCAGTGCTGAGCTGGGACTGTTGTTTG
CCCAGCCTGGGCTGCAGAAAGCAGCAGTTAAAGTTCGTTTCTGGTCACTGCTCCAGGAAGCCACCTTACTCTGAGGGTCAAGAATTGCCG
CTTCCTTTTAGTTACTGTAAGTTCCTCCTCTGCCCCTGGTTTGTTTCCCGCGGCACTTCTGGATACCCCCAGGTCCCAGACCCTTCCAGA
CTCAAACCATGAACTTTCGGCAGCTGCTGTTGCACTTGCCACGTTATCTTGGAGCCTCGGGTTCCCCGCGTCGCCTGTGGTGGTCCCCGT
CCCTCGACACCATCTCCTCGGTGGGCTCTTGGCGTGGTCGGTCCTCCAAGTCCCCGGCCCACTGGAATCAGGTAGTGTCAGAGGCGGAGA
AGATCGTGGGGTACCCCACGTCCTTCATGAGCCTTCGCTGCCTGCTGAGCGACGAGCTCAGCAACATCGCTATGCAGGTGCGGAAGCTGG
TGGGCACTCAGCACCCTCTGCTTACCACAGCCAGGGGGCTTGTACATGACAGCTGGAATAGCCTCCAGTTGAGGGGCTTGGTGGTGCTCC
TTATCTCTAAAGCAGCTGGGCCCAGCAGCGTGAACACTTCATGTCAGAACTATGACATGGTCAGTGGGATCTACTCATGTCAAAGAAGTT
TGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCAC
TGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGA
ACACCAAGAGCTCTCAGCATGGCGGCTCCTCTACGTCACTTGCGTCCACCAAAGTCTGCAGCTCGATGGATGAGAACGATGGCCCTGGAG
AAGAAGTGTCGGAGGAAGGCTTCCAGATTCCAGCTACAATAACAGAACGATATAAAGTCGGAAGAACAATAGGAGATGGAAATTTTGCTG
TTGTCAAGGAATGTGTAGAAAGATCGACTGCTAGAGAGTATGCTCTGAAAATTATCAAGAAAAGCAAATGTCGAGGCAAAGAGCACATGA
TCCAGAATGAAGTGTCTATTTTAAGAAGAGTGAAGCATCCCAATATCGTTCTTCTGATTGAGGAGATGGATGTGCCAACTGAACTGTATC
TTGTCATGGAATTAGTAAAGGGGGGAGACCTTTTTGATGCCATTACTTCCACTAACAAATACACCGAGAGAGACGCCAGTGGGATGCTGT
ACAACCTAGCCAGCGCCATCAAATACCTGCATAGCCTGAACATCGTCCACCGTGATATCAAGCCAGAGAACCTGCTGGTGTATGAGCACC
AAGATGGCAGCAAATCACTGAAGCTGGGTGACTTTGGACTGGCCACCATTGTAGACGGCCCCCTGTACACAGTCTGTGGCACCCCAACAT
ACGTGGCTCCAGAAATCATTGCAGAGACTGGATACGGCCTCAAGGTGGACATCTGGGCAGCAGGTGTAATCACTTATATCCTGCTGTGTG
GTTTCCCTCCATTCCGTGGAAGTGGTGATGACCAGGAGGTGCTTTTTGATCAGATTTTGATGGGGCAGGTGGACTTTCCTTCTCCATACT
GGGATAATGTTTCCGATTCTGCAAAGGAGCTCATTACCATGATGCTGTTGGTCGATGTAGATCAGCGATTTTCTGCTGTTCAAGTACTTG
AGCATCCCTGGGTTAATGATGATGGCCTCCCAGAAAATGAACATCAGCTGTCAGTAGCTGGAAAGATAAAGAAGCATTTCAACACAGGCC
CCAAGCCGAATAGCACAGCAGCTGGAGTTTCTGTCATAGCACTGGACCACGGGTTTACCATCAAGAGATCAGGGTCTTTGGACTACTACC
AGCAACCAGGAATGTATTGGATAAGACCACCGCTCTTGATAAGGAGAGGCAGGTTTTCCGACGAAGACGCAACCAGGATGTGAGGAGCCG
GTACAAGGCGCAGCCAGCTCCTCCCGAACTCAACTCGGAATCGGAAGACTACTCCCCAAGCTCCTCCGAGACTGTTCGCTCCCCTAACTC
GCCCTTTTAATAAGACCCTTTTACTCAAAGTCCTAGCTTAACCCTTTGAGACTCTGAGATTTTTTTCCCCCAAATTTGTGTAAAACAGTT
TCATCTGATCTATCTAGCGCTCAATGCTTGAATGGCAGAACTGAAAGTGTTTTCAGGTATCTTTGTAGCGGTTTCCCTTTACTGAATAAG
ATGACACGTGGTGATTGTGAAGATGGTAATTTGCTGCTAATAGAGTCCTCAAAGGGTTAAGGCCAATTTGCAATTTTTTTTTAAACTTAG
AAGCAATGAATGTTTTCATCAGTCAAGCTAGGATCTGCAGTATGTAATATAGCACTTGTTAACCCTCTGAGTGCATAGAATTTTATTGAG
AATTCTTGTTTGGGAATTTTTCAGGCCTTTGGATGTATACACACATGTTTCTTGATTTTACTGCAGATCAAGGGGTGTTGTTAGATGCTG
AAATGTCCAGAAAAGAAGGACATTTAGAATGATATCTTGTTTGTCCTTTTCTGTGGGTTTAGAACGTGGCAGGTTTATAACTTCGACACA
CGCACGGTTCTTTCTTCTTCACAATCCTATTCAGAAACAGATTTTTTTTTTCATTAGAGATATGACTGTCAGTTGCAGTGAGTTCTGCAT
CCCAAGTGGAGGGAATTGGGTTTGTGGCAAAGAGCTTGACCCAGGAAATAGATGGTGCCCCCCAAATTGTCTCCACATGAAGATGTACTG
ATGACGCCCCAGAAATGCTGCTTCCATATCAGCTGCTGCTAGCGCCAGCGCAGACTCTCAGGGAGTCACCACAGCTTGTCTTGTGCTTGG
TGAGTGAGGGTCTCTCTACTCAGTGTCAGACATCTACAGGAAAGAAACAACTGGTGGAAAAGAGCAATAAATTGCCCGGTGCTCTGCAGG
GCTGGAATTTCAAACAGAAAGAGGGAATAAGATCCTGTGATTTTTCTCACCTGCTTTTCCACGCACTGTGGTCATCACTGTGCAATCTAC
ATCTAGTATGAAATCCACACATAGGAGAGCTGGGGCACAAGGGGACTGGAGGCAGTTGCTTTGCAAGATGGCTGAGGAGAAAGCACACTG
GGAACACAATCCAGAATGTTCTAACAATAAGTTTTCAGTGAATAAACCACTGGCAAGACAATTCCATGTGCACCTTTAGGTTACCTATAT
AGTCTCCTAGGAAGATCAGGATGAAAGACCTAGATGATACCCCTGAGGATAAAACCTCCATCCCCTAAAATGATTTTTTTTAAATACCAC
TGTCTTTAGCTGTCCAGGAGGTCAGAGTGTTTTTTCTGTCTTTGGGCCAAGTCCTGTCTGAGACCTGTATTTTCACTCTTGTTACCAAAT
CTATCTCCCTAGTGCAGTGTCTCCAGGCCTGAGTTTCTTCTGGAACAGATTCCATTTTAGAATGGGGATTCACAGGTTCTGTGCATCACC
ACAGTGCTCAGAGAGGATTCTCCTGGGGTGTCTTAGAGGCAGGTGCCCAACTCAAATGTATTCCCAAGGTTTGCTGGGCTCTGGGATCCA
CGAGACAACCAGAGAGGGATATCTCATGAAATTTGCATCTGGTGGCTGAACAGTACCTATGTTCTCTGTTTTGAATATACTTTAATACCT
GAGAGTCTTAAAATTTGTGAACAACGTTTCTATAGTCCTTTATTTTCAAATGCACATTGATCTTCACTTGCTGCATTTTTACTCTTCAAC
CCTGAAACTATGGTCTACATTAATATGGATTTTTAAATCACATGTCATTACTTTTGCAACACCATCACCAAAATTTTTTGCTCTTTTACA
TTTAGGTTCATCTCTGTGGTCTGTGTTGTCCTGACATGTAAAAAGCATATCGTTTATTGAGGTTTTTTTCCCCCCCTTTTAGAGCATCCG
GAAGTGATAACACGCAAAATCACAAAGTAGCATAAATCAGTAAATTAGTTGAGTTGTTTTTGGGGGGGAGGTGGGGGTAGGGGGCACAGA
ACACCAGAAAGAGTGTTGGTGTGTAGGTAGATTCCATATTAATGAGGAACACTGAACTAGTTGGAAATTACTGCTTTCTCTAGAAATATA
AAGCAAAGCACTATTCCAAGGCTATGGAGTAGCTCTACAGCCTGGCCTCAACTCTAAAAGTGTGAAGAATGCAATGGGCAGAGACCTACC
TGCAGTGGACTGTCATTTTCCTTTCTTTCTCTGAATTACTGCTTTTTCTGTGGGCATTAACTATATTGCTACAGCATCTAGTGTACTGAG
CCTGCGGTGCATGGCTCAGGCCTTTTCCCATCGACGTCTAGGGGGACTCTGGACCGTGTGAAGCTAGGGGGTGTTTCTCAGCACACTGCA
GAAGGGCAGCTCAGAAGAATGCAGGGCCCATTCAGCATGGGGATCCCAGCACATCACTGTAGAATTTGAGTGATCTATGCTGAATAAACA
GTGGAATGTGACCAGTCAAGTAGAAATCTTGAGTAATCAGATGGAATGCAATCTTTCTAACATTAAGCTACCAAGATCCTGAATGTCAGA
GATGTACTCAGAGGGTTAACAGACAAGCACAAGGCATGCTGACTACATTGGTGTATCCAGATTGCTTTGCTTTTAGCCAGTGCTTTCTAA
TTTTTTTCTCGACATTCTTGGGATAGTTCAAGTTTGAAATAATTAAGTGGTGGTGTTCTTTAAGGAATTTCTATAACCAAATTGATCTTA
TTTTTGATTTCACTTATCATAGAACAAATATGTATCATTATGGCAGTGTATCTATGTAATTATCAATTTAATCATCACCACCGGTGTTTC
CATATTTTTTCCCAAGTATTTAATATAGCTCTCTTATGGTGGTGGCCTGGTGATGGGGACCGTCTTTCTTTTACTGACACATGACCAATC
ATATGGTATTTTCAAGGGAATTTTAAGATTCATCTTTTCAGTTTGATAGTAGACTAGTTAAGGAAGAACTCTTTCATTACTTGCATCGTG
TAAATCATCTCTGTAGACATGTGTTCATATTAATGAACACATTTTTTCTCAACATTGTAGCAGAAATCATTTTATTCGTCATGATCAATG
AATATGTGATTTGCTCCAGATCGTTAGAAGGAAAAGTAAGATTTCAGTCATCAAAAATGTTTTTACCGTAGCCCTCATCTAACTTACACG

>64082_64082_3_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000369037_DCLK1_chr13_36413313_ENST00000255448_length(amino acids)=617AA_BP=233
MPLVCFPRHFWIPPGPRPFQTQTMNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSKSPAHWNQVVSEAEKIVGYPTSFM
SLRCLLSDELSNIAMQVRKLVGTQHPLLTTARGLVHDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHI
ALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQI
PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGD
LFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAET
GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGL

--------------------------------------------------------------
>64082_64082_4_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000369037_DCLK1_chr13_36413313_ENST00000360631_length(transcript)=5290nt_BP=908nt
TGCCTCCAATATGGCGTCCTCCACATAGGCAGTGGCTGTGGTTTCTACCCCGGGTGGCCGGGGGCAGTGCTGAGCTGGGACTGTTGTTTG
CCCAGCCTGGGCTGCAGAAAGCAGCAGTTAAAGTTCGTTTCTGGTCACTGCTCCAGGAAGCCACCTTACTCTGAGGGTCAAGAATTGCCG
CTTCCTTTTAGTTACTGTAAGTTCCTCCTCTGCCCCTGGTTTGTTTCCCGCGGCACTTCTGGATACCCCCAGGTCCCAGACCCTTCCAGA
CTCAAACCATGAACTTTCGGCAGCTGCTGTTGCACTTGCCACGTTATCTTGGAGCCTCGGGTTCCCCGCGTCGCCTGTGGTGGTCCCCGT
CCCTCGACACCATCTCCTCGGTGGGCTCTTGGCGTGGTCGGTCCTCCAAGTCCCCGGCCCACTGGAATCAGGTAGTGTCAGAGGCGGAGA
AGATCGTGGGGTACCCCACGTCCTTCATGAGCCTTCGCTGCCTGCTGAGCGACGAGCTCAGCAACATCGCTATGCAGGTGCGGAAGCTGG
TGGGCACTCAGCACCCTCTGCTTACCACAGCCAGGGGGCTTGTACATGACAGCTGGAATAGCCTCCAGTTGAGGGGCTTGGTGGTGCTCC
TTATCTCTAAAGCAGCTGGGCCCAGCAGCGTGAACACTTCATGTCAGAACTATGACATGGTCAGTGGGATCTACTCATGTCAAAGAAGTT
TGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCAC
TGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGA
ACACCAAGAGCTCTCAGCATGGCGGCTCCTCTACGTCACTTGCGTCCACCAAAGTCTGCAGCTCGATGGATGAGAACGATGGCCCTGGAG
AAGAAGTGTCGGAGGAAGGCTTCCAGATTCCAGCTACAATAACAGAACGATATAAAGTCGGAAGAACAATAGGAGATGGAAATTTTGCTG
TTGTCAAGGAATGTGTAGAAAGATCGACTGCTAGAGAGTATGCTCTGAAAATTATCAAGAAAAGCAAATGTCGAGGCAAAGAGCACATGA
TCCAGAATGAAGTGTCTATTTTAAGAAGAGTGAAGCATCCCAATATCGTTCTTCTGATTGAGGAGATGGATGTGCCAACTGAACTGTATC
TTGTCATGGAATTAGTAAAGGGGGGAGACCTTTTTGATGCCATTACTTCCACTAACAAATACACCGAGAGAGACGCCAGTGGGATGCTGT
ACAACCTAGCCAGCGCCATCAAATACCTGCATAGCCTGAACATCGTCCACCGTGATATCAAGCCAGAGAACCTGCTGGTGTATGAGCACC
AAGATGGCAGCAAATCACTGAAGCTGGGTGACTTTGGACTGGCCACCATTGTAGACGGCCCCCTGTACACAGTCTGTGGCACCCCAACAT
ACGTGGCTCCAGAAATCATTGCAGAGACTGGATACGGCCTCAAGGTGGACATCTGGGCAGCAGGTGTAATCACTTATATCCTGCTGTGTG
GTTTCCCTCCATTCCGTGGAAGTGGTGATGACCAGGAGGTGCTTTTTGATCAGATTTTGATGGGGCAGGTGGACTTTCCTTCTCCATACT
GGGATAATGTTTCCGATTCTGCAAAGGAGCTCATTACCATGATGCTGTTGGTCGATGTAGATCAGCGATTTTCTGCTGTTCAAGTACTTG
AGCATCCCTGGGTTAATGATGATGGCCTCCCAGAAAATGAACATCAGCTGTCAGTAGCTGGAAAGATAAAGAAGCATTTCAACACAGGCC
CCAAGCCGAATAGCACAGCAGCTGGAGTTTCTGTCATAGCAACCACCGCTCTTGATAAGGAGAGGCAGGTTTTCCGACGAAGACGCAACC
AGGATGTGAGGAGCCGGTACAAGGCGCAGCCAGCTCCTCCCGAACTCAACTCGGAATCGGAAGACTACTCCCCAAGCTCCTCCGAGACTG
TTCGCTCCCCTAACTCGCCCTTTTAATAAGACCCTTTTACTCAAAGTCCTAGCTTAACCCTTTGAGACTCTGAGATTTTTTTCCCCCAAA
TTTGTGTAAAACAGTTTCATCTGATCTATCTAGCGCTCAATGCTTGAATGGCAGAACTGAAAGTGTTTTCAGGTATCTTTGTAGCGGTTT
CCCTTTACTGAATAAGATGACACGTGGTGATTGTGAAGATGGTAATTTGCTGCTAATAGAGTCCTCAAAGGGTTAAGGCCAATTTGCAAT
TTTTTTTTAAACTTAGAAGCAATGAATGTTTTCATCAGTCAAGCTAGGATCTGCAGTATGTAATATAGCACTTGTTAACCCTCTGAGTGC
ATAGAATTTTATTGAGAATTCTTGTTTGGGAATTTTTCAGGCCTTTGGATGTATACACACATGTTTCTTGATTTTACTGCAGATCAAGGG
GTGTTGTTAGATGCTGAAATGTCCAGAAAAGAAGGACATTTAGAATGATATCTTGTTTGTCCTTTTCTGTGGGTTTAGAACGTGGCAGGT
TTATAACTTCGACACACGCACGGTTCTTTCTTCTTCACAATCCTATTCAGAAACAGATTTTTTTTTTCATTAGAGATATGACTGTCAGTT
GCAGTGAGTTCTGCATCCCAAGTGGAGGGAATTGGGTTTGTGGCAAAGAGCTTGACCCAGGAAATAGATGGTGCCCCCCAAATTGTCTCC
ACATGAAGATGTACTGATGACGCCCCAGAAATGCTGCTTCCATATCAGCTGCTGCTAGCGCCAGCGCAGACTCTCAGGGAGTCACCACAG
CTTGTCTTGTGCTTGGTGAGTGAGGGTCTCTCTACTCAGTGTCAGACATCTACAGGAAAGAAACAACTGGTGGAAAAGAGCAATAAATTG
CCCGGTGCTCTGCAGGGCTGGAATTTCAAACAGAAAGAGGGAATAAGATCCTGTGATTTTTCTCACCTGCTTTTCCACGCACTGTGGTCA
TCACTGTGCAATCTACATCTAGTATGAAATCCACACATAGGAGAGCTGGGGCACAAGGGGACTGGAGGCAGTTGCTTTGCAAGATGGCTG
AGGAGAAAGCACACTGGGAACACAATCCAGAATGTTCTAACAATAAGTTTTCAGTGAATAAACCACTGGCAAGACAATTCCATGTGCACC
TTTAGGTTACCTATATAGTCTCCTAGGAAGATCAGGATGAAAGACCTAGATGATACCCCTGAGGATAAAACCTCCATCCCCTAAAATGAT
TTTTTTTAAATACCACTGTCTTTAGCTGTCCAGGAGGTCAGAGTGTTTTTTCTGTCTTTGGGCCAAGTCCTGTCTGAGACCTGTATTTTC
ACTCTTGTTACCAAATCTATCTCCCTAGTGCAGTGTCTCCAGGCCTGAGTTTCTTCTGGAACAGATTCCATTTTAGAATGGGGATTCACA
GGTTCTGTGCATCACCACAGTGCTCAGAGAGGATTCTCCTGGGGTGTCTTAGAGGCAGGTGCCCAACTCAAATGTATTCCCAAGGTTTGC
TGGGCTCTGGGATCCACGAGACAACCAGAGAGGGATATCTCATGAAATTTGCATCTGGTGGCTGAACAGTACCTATGTTCTCTGTTTTGA
ATATACTTTAATACCTGAGAGTCTTAAAATTTGTGAACAACGTTTCTATAGTCCTTTATTTTCAAATGCACATTGATCTTCACTTGCTGC
ATTTTTACTCTTCAACCCTGAAACTATGGTCTACATTAATATGGATTTTTAAATCACATGTCATTACTTTTGCAACACCATCACCAAAAT
TTTTTGCTCTTTTACATTTAGGTTCATCTCTGTGGTCTGTGTTGTCCTGACATGTAAAAAGCATATCGTTTATTGAGGTTTTTTTCCCCC
CCTTTTAGAGCATCCGGAAGTGATAACACGCAAAATCACAAAGTAGCATAAATCAGTAAATTAGTTGAGTTGTTTTTGGGGGGGAGGTGG
GGGTAGGGGGCACAGAACACCAGAAAGAGTGTTGGTGTGTAGGTAGATTCCATATTAATGAGGAACACTGAACTAGTTGGAAATTACTGC
TTTCTCTAGAAATATAAAGCAAAGCACTATTCCAAGGCTATGGAGTAGCTCTACAGCCTGGCCTCAACTCTAAAAGTGTGAAGAATGCAA
TGGGCAGAGACCTACCTGCAGTGGACTGTCATTTTCCTTTCTTTCTCTGAATTACTGCTTTTTCTGTGGGCATTAACTATATTGCTACAG
CATCTAGTGTACTGAGCCTGCGGTGCATGGCTCAGGCCTTTTCCCATCGACGTCTAGGGGGACTCTGGACCGTGTGAAGCTAGGGGGTGT
TTCTCAGCACACTGCAGAAGGGCAGCTCAGAAGAATGCAGGGCCCATTCAGCATGGGGATCCCAGCACATCACTGTAGAATTTGAGTGAT
CTATGCTGAATAAACAGTGGAATGTGACCAGTCAAGTAGAAATCTTGAGTAATCAGATGGAATGCAATCTTTCTAACATTAAGCTACCAA
GATCCTGAATGTCAGAGATGTACTCAGAGGGTTAACAGACAAGCACAAGGCATGCTGACTACATTGGTGTATCCAGATTGCTTTGCTTTT
AGCCAGTGCTTTCTAATTTTTTTCTCGACATTCTTGGGATAGTTCAAGTTTGAAATAATTAAGTGGTGGTGTTCTTTAAGGAATTTCTAT
AACCAAATTGATCTTATTTTTGATTTCACTTATCATAGAACAAATATGTATCATTATGGCAGTGTATCTATGTAATTATCAATTTAATCA
TCACCACCGGTGTTTCCATATTTTTTCCCAAGTATTTAATATAGCTCTCTTATGGTGGTGGCCTGGTGATGGGGACCGTCTTTCTTTTAC
TGACACATGACCAATCATATGGTATTTTCAAGGGAATTTTAAGATTCATCTTTTCAGTTTGATAGTAGACTAGTTAAGGAAGAACTCTTT
CATTACTTGCATCGTGTAAATCATCTCTGTAGACATGTGTTCATATTAATGAACACATTTTTTCTCAACATTGTAGCAGAAATCATTTTA
TTCGTCATGATCAATGAATATGTGATTTGCTCCAGATCGTTAGAAGGAAAAGTAAGATTTCAGTCATCAAAAATGTTTTTACCGTAGCCC

>64082_64082_4_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000369037_DCLK1_chr13_36413313_ENST00000360631_length(amino acids)=628AA_BP=233
MPLVCFPRHFWIPPGPRPFQTQTMNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSKSPAHWNQVVSEAEKIVGYPTSFM
SLRCLLSDELSNIAMQVRKLVGTQHPLLTTARGLVHDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHI
ALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQI
PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGD
LFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAET
GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGL

--------------------------------------------------------------
>64082_64082_5_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000453874_DCLK1_chr13_36413313_ENST00000255448_length(transcript)=5357nt_BP=901nt
AATATGGCGTCCTCCACATAGGCAGTGGCTGTGGTTTCTACCCCGGGTGGCCGGGGGCAGTGCTGAGCTGGGACTGTTGTTTGCCCAGCC
TGGGCTGCAGAAAGCAGCAGTTAAAGTTCGTTTCTGGTCACTGCTCCAGGAAGCCACCTTACTCTGAGGGTCAAGAATTGCCGCTTCCTT
TTAGTTACTGTAAGTTCCTCCTCTGCCCCTGGTTTGTTTCCCGCGGCACTTCTGGATACCCCCAGGTCCCAGACCCTTCCAGACTCAAAC
CATGAACTTTCGGCAGCTGCTGTTGCACTTGCCACGTTATCTTGGAGCCTCGGGTTCCCCGCGTCGCCTGTGGTGGTCCCCGTCCCTCGA
CACCATCTCCTCGGTGGGCTCTTGGCGTGGTCGGTCCTCCAAGTCCCCGGCCCACTGGAATCAGGTAGTGTCAGAGGCGGAGAAGATCGT
GGGGTACCCCACGTCCTTCATGAGCCTTCGCTGCCTGCTGAGCGACGAGCTCAGCAACATCGCTATGCAGGTGCGGAAGCTGGTGGGCAC
TCAGCACCCTCTGCTTACCACAGCCAGGGGGCTTGTACATGACAGCTGGAATAGCCTCCAGTTGAGGGGCTTGGTGGTGCTCCTTATCTC
TAAAGCAGCTGGGCCCAGCAGCGTGAACACTTCATGTCAGAACTATGACATGGTCAGTGGGATCTACTCATGTCAAAGAAGTTTGGCAGA
GATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCACTGAAAGA
CATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGAACACCAA
GAGCTCTCAGCATGGCGGCTCCTCTACGTCACTTGCGTCCACCAAAGTCTGCAGCTCGATGGATGAGAACGATGGCCCTGGAGAAGAAGT
GTCGGAGGAAGGCTTCCAGATTCCAGCTACAATAACAGAACGATATAAAGTCGGAAGAACAATAGGAGATGGAAATTTTGCTGTTGTCAA
GGAATGTGTAGAAAGATCGACTGCTAGAGAGTATGCTCTGAAAATTATCAAGAAAAGCAAATGTCGAGGCAAAGAGCACATGATCCAGAA
TGAAGTGTCTATTTTAAGAAGAGTGAAGCATCCCAATATCGTTCTTCTGATTGAGGAGATGGATGTGCCAACTGAACTGTATCTTGTCAT
GGAATTAGTAAAGGGGGGAGACCTTTTTGATGCCATTACTTCCACTAACAAATACACCGAGAGAGACGCCAGTGGGATGCTGTACAACCT
AGCCAGCGCCATCAAATACCTGCATAGCCTGAACATCGTCCACCGTGATATCAAGCCAGAGAACCTGCTGGTGTATGAGCACCAAGATGG
CAGCAAATCACTGAAGCTGGGTGACTTTGGACTGGCCACCATTGTAGACGGCCCCCTGTACACAGTCTGTGGCACCCCAACATACGTGGC
TCCAGAAATCATTGCAGAGACTGGATACGGCCTCAAGGTGGACATCTGGGCAGCAGGTGTAATCACTTATATCCTGCTGTGTGGTTTCCC
TCCATTCCGTGGAAGTGGTGATGACCAGGAGGTGCTTTTTGATCAGATTTTGATGGGGCAGGTGGACTTTCCTTCTCCATACTGGGATAA
TGTTTCCGATTCTGCAAAGGAGCTCATTACCATGATGCTGTTGGTCGATGTAGATCAGCGATTTTCTGCTGTTCAAGTACTTGAGCATCC
CTGGGTTAATGATGATGGCCTCCCAGAAAATGAACATCAGCTGTCAGTAGCTGGAAAGATAAAGAAGCATTTCAACACAGGCCCCAAGCC
GAATAGCACAGCAGCTGGAGTTTCTGTCATAGCACTGGACCACGGGTTTACCATCAAGAGATCAGGGTCTTTGGACTACTACCAGCAACC
AGGAATGTATTGGATAAGACCACCGCTCTTGATAAGGAGAGGCAGGTTTTCCGACGAAGACGCAACCAGGATGTGAGGAGCCGGTACAAG
GCGCAGCCAGCTCCTCCCGAACTCAACTCGGAATCGGAAGACTACTCCCCAAGCTCCTCCGAGACTGTTCGCTCCCCTAACTCGCCCTTT
TAATAAGACCCTTTTACTCAAAGTCCTAGCTTAACCCTTTGAGACTCTGAGATTTTTTTCCCCCAAATTTGTGTAAAACAGTTTCATCTG
ATCTATCTAGCGCTCAATGCTTGAATGGCAGAACTGAAAGTGTTTTCAGGTATCTTTGTAGCGGTTTCCCTTTACTGAATAAGATGACAC
GTGGTGATTGTGAAGATGGTAATTTGCTGCTAATAGAGTCCTCAAAGGGTTAAGGCCAATTTGCAATTTTTTTTTAAACTTAGAAGCAAT
GAATGTTTTCATCAGTCAAGCTAGGATCTGCAGTATGTAATATAGCACTTGTTAACCCTCTGAGTGCATAGAATTTTATTGAGAATTCTT
GTTTGGGAATTTTTCAGGCCTTTGGATGTATACACACATGTTTCTTGATTTTACTGCAGATCAAGGGGTGTTGTTAGATGCTGAAATGTC
CAGAAAAGAAGGACATTTAGAATGATATCTTGTTTGTCCTTTTCTGTGGGTTTAGAACGTGGCAGGTTTATAACTTCGACACACGCACGG
TTCTTTCTTCTTCACAATCCTATTCAGAAACAGATTTTTTTTTTCATTAGAGATATGACTGTCAGTTGCAGTGAGTTCTGCATCCCAAGT
GGAGGGAATTGGGTTTGTGGCAAAGAGCTTGACCCAGGAAATAGATGGTGCCCCCCAAATTGTCTCCACATGAAGATGTACTGATGACGC
CCCAGAAATGCTGCTTCCATATCAGCTGCTGCTAGCGCCAGCGCAGACTCTCAGGGAGTCACCACAGCTTGTCTTGTGCTTGGTGAGTGA
GGGTCTCTCTACTCAGTGTCAGACATCTACAGGAAAGAAACAACTGGTGGAAAAGAGCAATAAATTGCCCGGTGCTCTGCAGGGCTGGAA
TTTCAAACAGAAAGAGGGAATAAGATCCTGTGATTTTTCTCACCTGCTTTTCCACGCACTGTGGTCATCACTGTGCAATCTACATCTAGT
ATGAAATCCACACATAGGAGAGCTGGGGCACAAGGGGACTGGAGGCAGTTGCTTTGCAAGATGGCTGAGGAGAAAGCACACTGGGAACAC
AATCCAGAATGTTCTAACAATAAGTTTTCAGTGAATAAACCACTGGCAAGACAATTCCATGTGCACCTTTAGGTTACCTATATAGTCTCC
TAGGAAGATCAGGATGAAAGACCTAGATGATACCCCTGAGGATAAAACCTCCATCCCCTAAAATGATTTTTTTTAAATACCACTGTCTTT
AGCTGTCCAGGAGGTCAGAGTGTTTTTTCTGTCTTTGGGCCAAGTCCTGTCTGAGACCTGTATTTTCACTCTTGTTACCAAATCTATCTC
CCTAGTGCAGTGTCTCCAGGCCTGAGTTTCTTCTGGAACAGATTCCATTTTAGAATGGGGATTCACAGGTTCTGTGCATCACCACAGTGC
TCAGAGAGGATTCTCCTGGGGTGTCTTAGAGGCAGGTGCCCAACTCAAATGTATTCCCAAGGTTTGCTGGGCTCTGGGATCCACGAGACA
ACCAGAGAGGGATATCTCATGAAATTTGCATCTGGTGGCTGAACAGTACCTATGTTCTCTGTTTTGAATATACTTTAATACCTGAGAGTC
TTAAAATTTGTGAACAACGTTTCTATAGTCCTTTATTTTCAAATGCACATTGATCTTCACTTGCTGCATTTTTACTCTTCAACCCTGAAA
CTATGGTCTACATTAATATGGATTTTTAAATCACATGTCATTACTTTTGCAACACCATCACCAAAATTTTTTGCTCTTTTACATTTAGGT
TCATCTCTGTGGTCTGTGTTGTCCTGACATGTAAAAAGCATATCGTTTATTGAGGTTTTTTTCCCCCCCTTTTAGAGCATCCGGAAGTGA
TAACACGCAAAATCACAAAGTAGCATAAATCAGTAAATTAGTTGAGTTGTTTTTGGGGGGGAGGTGGGGGTAGGGGGCACAGAACACCAG
AAAGAGTGTTGGTGTGTAGGTAGATTCCATATTAATGAGGAACACTGAACTAGTTGGAAATTACTGCTTTCTCTAGAAATATAAAGCAAA
GCACTATTCCAAGGCTATGGAGTAGCTCTACAGCCTGGCCTCAACTCTAAAAGTGTGAAGAATGCAATGGGCAGAGACCTACCTGCAGTG
GACTGTCATTTTCCTTTCTTTCTCTGAATTACTGCTTTTTCTGTGGGCATTAACTATATTGCTACAGCATCTAGTGTACTGAGCCTGCGG
TGCATGGCTCAGGCCTTTTCCCATCGACGTCTAGGGGGACTCTGGACCGTGTGAAGCTAGGGGGTGTTTCTCAGCACACTGCAGAAGGGC
AGCTCAGAAGAATGCAGGGCCCATTCAGCATGGGGATCCCAGCACATCACTGTAGAATTTGAGTGATCTATGCTGAATAAACAGTGGAAT
GTGACCAGTCAAGTAGAAATCTTGAGTAATCAGATGGAATGCAATCTTTCTAACATTAAGCTACCAAGATCCTGAATGTCAGAGATGTAC
TCAGAGGGTTAACAGACAAGCACAAGGCATGCTGACTACATTGGTGTATCCAGATTGCTTTGCTTTTAGCCAGTGCTTTCTAATTTTTTT
CTCGACATTCTTGGGATAGTTCAAGTTTGAAATAATTAAGTGGTGGTGTTCTTTAAGGAATTTCTATAACCAAATTGATCTTATTTTTGA
TTTCACTTATCATAGAACAAATATGTATCATTATGGCAGTGTATCTATGTAATTATCAATTTAATCATCACCACCGGTGTTTCCATATTT
TTTCCCAAGTATTTAATATAGCTCTCTTATGGTGGTGGCCTGGTGATGGGGACCGTCTTTCTTTTACTGACACATGACCAATCATATGGT
ATTTTCAAGGGAATTTTAAGATTCATCTTTTCAGTTTGATAGTAGACTAGTTAAGGAAGAACTCTTTCATTACTTGCATCGTGTAAATCA
TCTCTGTAGACATGTGTTCATATTAATGAACACATTTTTTCTCAACATTGTAGCAGAAATCATTTTATTCGTCATGATCAATGAATATGT
GATTTGCTCCAGATCGTTAGAAGGAAAAGTAAGATTTCAGTCATCAAAAATGTTTTTACCGTAGCCCTCATCTAACTTACACGTGGTGCA

>64082_64082_5_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000453874_DCLK1_chr13_36413313_ENST00000255448_length(amino acids)=617AA_BP=233
MPLVCFPRHFWIPPGPRPFQTQTMNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSKSPAHWNQVVSEAEKIVGYPTSFM
SLRCLLSDELSNIAMQVRKLVGTQHPLLTTARGLVHDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHI
ALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQI
PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGD
LFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAET
GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGL

--------------------------------------------------------------
>64082_64082_6_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000453874_DCLK1_chr13_36413313_ENST00000360631_length(transcript)=5283nt_BP=901nt
AATATGGCGTCCTCCACATAGGCAGTGGCTGTGGTTTCTACCCCGGGTGGCCGGGGGCAGTGCTGAGCTGGGACTGTTGTTTGCCCAGCC
TGGGCTGCAGAAAGCAGCAGTTAAAGTTCGTTTCTGGTCACTGCTCCAGGAAGCCACCTTACTCTGAGGGTCAAGAATTGCCGCTTCCTT
TTAGTTACTGTAAGTTCCTCCTCTGCCCCTGGTTTGTTTCCCGCGGCACTTCTGGATACCCCCAGGTCCCAGACCCTTCCAGACTCAAAC
CATGAACTTTCGGCAGCTGCTGTTGCACTTGCCACGTTATCTTGGAGCCTCGGGTTCCCCGCGTCGCCTGTGGTGGTCCCCGTCCCTCGA
CACCATCTCCTCGGTGGGCTCTTGGCGTGGTCGGTCCTCCAAGTCCCCGGCCCACTGGAATCAGGTAGTGTCAGAGGCGGAGAAGATCGT
GGGGTACCCCACGTCCTTCATGAGCCTTCGCTGCCTGCTGAGCGACGAGCTCAGCAACATCGCTATGCAGGTGCGGAAGCTGGTGGGCAC
TCAGCACCCTCTGCTTACCACAGCCAGGGGGCTTGTACATGACAGCTGGAATAGCCTCCAGTTGAGGGGCTTGGTGGTGCTCCTTATCTC
TAAAGCAGCTGGGCCCAGCAGCGTGAACACTTCATGTCAGAACTATGACATGGTCAGTGGGATCTACTCATGTCAAAGAAGTTTGGCAGA
GATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCACTGAAAGA
CATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGAACACCAA
GAGCTCTCAGCATGGCGGCTCCTCTACGTCACTTGCGTCCACCAAAGTCTGCAGCTCGATGGATGAGAACGATGGCCCTGGAGAAGAAGT
GTCGGAGGAAGGCTTCCAGATTCCAGCTACAATAACAGAACGATATAAAGTCGGAAGAACAATAGGAGATGGAAATTTTGCTGTTGTCAA
GGAATGTGTAGAAAGATCGACTGCTAGAGAGTATGCTCTGAAAATTATCAAGAAAAGCAAATGTCGAGGCAAAGAGCACATGATCCAGAA
TGAAGTGTCTATTTTAAGAAGAGTGAAGCATCCCAATATCGTTCTTCTGATTGAGGAGATGGATGTGCCAACTGAACTGTATCTTGTCAT
GGAATTAGTAAAGGGGGGAGACCTTTTTGATGCCATTACTTCCACTAACAAATACACCGAGAGAGACGCCAGTGGGATGCTGTACAACCT
AGCCAGCGCCATCAAATACCTGCATAGCCTGAACATCGTCCACCGTGATATCAAGCCAGAGAACCTGCTGGTGTATGAGCACCAAGATGG
CAGCAAATCACTGAAGCTGGGTGACTTTGGACTGGCCACCATTGTAGACGGCCCCCTGTACACAGTCTGTGGCACCCCAACATACGTGGC
TCCAGAAATCATTGCAGAGACTGGATACGGCCTCAAGGTGGACATCTGGGCAGCAGGTGTAATCACTTATATCCTGCTGTGTGGTTTCCC
TCCATTCCGTGGAAGTGGTGATGACCAGGAGGTGCTTTTTGATCAGATTTTGATGGGGCAGGTGGACTTTCCTTCTCCATACTGGGATAA
TGTTTCCGATTCTGCAAAGGAGCTCATTACCATGATGCTGTTGGTCGATGTAGATCAGCGATTTTCTGCTGTTCAAGTACTTGAGCATCC
CTGGGTTAATGATGATGGCCTCCCAGAAAATGAACATCAGCTGTCAGTAGCTGGAAAGATAAAGAAGCATTTCAACACAGGCCCCAAGCC
GAATAGCACAGCAGCTGGAGTTTCTGTCATAGCAACCACCGCTCTTGATAAGGAGAGGCAGGTTTTCCGACGAAGACGCAACCAGGATGT
GAGGAGCCGGTACAAGGCGCAGCCAGCTCCTCCCGAACTCAACTCGGAATCGGAAGACTACTCCCCAAGCTCCTCCGAGACTGTTCGCTC
CCCTAACTCGCCCTTTTAATAAGACCCTTTTACTCAAAGTCCTAGCTTAACCCTTTGAGACTCTGAGATTTTTTTCCCCCAAATTTGTGT
AAAACAGTTTCATCTGATCTATCTAGCGCTCAATGCTTGAATGGCAGAACTGAAAGTGTTTTCAGGTATCTTTGTAGCGGTTTCCCTTTA
CTGAATAAGATGACACGTGGTGATTGTGAAGATGGTAATTTGCTGCTAATAGAGTCCTCAAAGGGTTAAGGCCAATTTGCAATTTTTTTT
TAAACTTAGAAGCAATGAATGTTTTCATCAGTCAAGCTAGGATCTGCAGTATGTAATATAGCACTTGTTAACCCTCTGAGTGCATAGAAT
TTTATTGAGAATTCTTGTTTGGGAATTTTTCAGGCCTTTGGATGTATACACACATGTTTCTTGATTTTACTGCAGATCAAGGGGTGTTGT
TAGATGCTGAAATGTCCAGAAAAGAAGGACATTTAGAATGATATCTTGTTTGTCCTTTTCTGTGGGTTTAGAACGTGGCAGGTTTATAAC
TTCGACACACGCACGGTTCTTTCTTCTTCACAATCCTATTCAGAAACAGATTTTTTTTTTCATTAGAGATATGACTGTCAGTTGCAGTGA
GTTCTGCATCCCAAGTGGAGGGAATTGGGTTTGTGGCAAAGAGCTTGACCCAGGAAATAGATGGTGCCCCCCAAATTGTCTCCACATGAA
GATGTACTGATGACGCCCCAGAAATGCTGCTTCCATATCAGCTGCTGCTAGCGCCAGCGCAGACTCTCAGGGAGTCACCACAGCTTGTCT
TGTGCTTGGTGAGTGAGGGTCTCTCTACTCAGTGTCAGACATCTACAGGAAAGAAACAACTGGTGGAAAAGAGCAATAAATTGCCCGGTG
CTCTGCAGGGCTGGAATTTCAAACAGAAAGAGGGAATAAGATCCTGTGATTTTTCTCACCTGCTTTTCCACGCACTGTGGTCATCACTGT
GCAATCTACATCTAGTATGAAATCCACACATAGGAGAGCTGGGGCACAAGGGGACTGGAGGCAGTTGCTTTGCAAGATGGCTGAGGAGAA
AGCACACTGGGAACACAATCCAGAATGTTCTAACAATAAGTTTTCAGTGAATAAACCACTGGCAAGACAATTCCATGTGCACCTTTAGGT
TACCTATATAGTCTCCTAGGAAGATCAGGATGAAAGACCTAGATGATACCCCTGAGGATAAAACCTCCATCCCCTAAAATGATTTTTTTT
AAATACCACTGTCTTTAGCTGTCCAGGAGGTCAGAGTGTTTTTTCTGTCTTTGGGCCAAGTCCTGTCTGAGACCTGTATTTTCACTCTTG
TTACCAAATCTATCTCCCTAGTGCAGTGTCTCCAGGCCTGAGTTTCTTCTGGAACAGATTCCATTTTAGAATGGGGATTCACAGGTTCTG
TGCATCACCACAGTGCTCAGAGAGGATTCTCCTGGGGTGTCTTAGAGGCAGGTGCCCAACTCAAATGTATTCCCAAGGTTTGCTGGGCTC
TGGGATCCACGAGACAACCAGAGAGGGATATCTCATGAAATTTGCATCTGGTGGCTGAACAGTACCTATGTTCTCTGTTTTGAATATACT
TTAATACCTGAGAGTCTTAAAATTTGTGAACAACGTTTCTATAGTCCTTTATTTTCAAATGCACATTGATCTTCACTTGCTGCATTTTTA
CTCTTCAACCCTGAAACTATGGTCTACATTAATATGGATTTTTAAATCACATGTCATTACTTTTGCAACACCATCACCAAAATTTTTTGC
TCTTTTACATTTAGGTTCATCTCTGTGGTCTGTGTTGTCCTGACATGTAAAAAGCATATCGTTTATTGAGGTTTTTTTCCCCCCCTTTTA
GAGCATCCGGAAGTGATAACACGCAAAATCACAAAGTAGCATAAATCAGTAAATTAGTTGAGTTGTTTTTGGGGGGGAGGTGGGGGTAGG
GGGCACAGAACACCAGAAAGAGTGTTGGTGTGTAGGTAGATTCCATATTAATGAGGAACACTGAACTAGTTGGAAATTACTGCTTTCTCT
AGAAATATAAAGCAAAGCACTATTCCAAGGCTATGGAGTAGCTCTACAGCCTGGCCTCAACTCTAAAAGTGTGAAGAATGCAATGGGCAG
AGACCTACCTGCAGTGGACTGTCATTTTCCTTTCTTTCTCTGAATTACTGCTTTTTCTGTGGGCATTAACTATATTGCTACAGCATCTAG
TGTACTGAGCCTGCGGTGCATGGCTCAGGCCTTTTCCCATCGACGTCTAGGGGGACTCTGGACCGTGTGAAGCTAGGGGGTGTTTCTCAG
CACACTGCAGAAGGGCAGCTCAGAAGAATGCAGGGCCCATTCAGCATGGGGATCCCAGCACATCACTGTAGAATTTGAGTGATCTATGCT
GAATAAACAGTGGAATGTGACCAGTCAAGTAGAAATCTTGAGTAATCAGATGGAATGCAATCTTTCTAACATTAAGCTACCAAGATCCTG
AATGTCAGAGATGTACTCAGAGGGTTAACAGACAAGCACAAGGCATGCTGACTACATTGGTGTATCCAGATTGCTTTGCTTTTAGCCAGT
GCTTTCTAATTTTTTTCTCGACATTCTTGGGATAGTTCAAGTTTGAAATAATTAAGTGGTGGTGTTCTTTAAGGAATTTCTATAACCAAA
TTGATCTTATTTTTGATTTCACTTATCATAGAACAAATATGTATCATTATGGCAGTGTATCTATGTAATTATCAATTTAATCATCACCAC
CGGTGTTTCCATATTTTTTCCCAAGTATTTAATATAGCTCTCTTATGGTGGTGGCCTGGTGATGGGGACCGTCTTTCTTTTACTGACACA
TGACCAATCATATGGTATTTTCAAGGGAATTTTAAGATTCATCTTTTCAGTTTGATAGTAGACTAGTTAAGGAAGAACTCTTTCATTACT
TGCATCGTGTAAATCATCTCTGTAGACATGTGTTCATATTAATGAACACATTTTTTCTCAACATTGTAGCAGAAATCATTTTATTCGTCA
TGATCAATGAATATGTGATTTGCTCCAGATCGTTAGAAGGAAAAGTAAGATTTCAGTCATCAAAAATGTTTTTACCGTAGCCCTCATCTA

>64082_64082_6_PDSS2-DCLK1_PDSS2_chr6_107595233_ENST00000453874_DCLK1_chr13_36413313_ENST00000360631_length(amino acids)=628AA_BP=233
MPLVCFPRHFWIPPGPRPFQTQTMNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSKSPAHWNQVVSEAEKIVGYPTSFM
SLRCLLSDELSNIAMQVRKLVGTQHPLLTTARGLVHDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHI
ALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQI
PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGD
LFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAET
GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDSS2-DCLK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDSS2-DCLK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDSS2-DCLK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource