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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PDZD8-BCAS1 (FusionGDB2 ID:64154)

Fusion Gene Summary for PDZD8-BCAS1

Fusion gene summary

Fusion gene information	Fusion gene name: PDZD8-BCAS1
	Fusion gene ID: 64154
		Hgene	Tgene
	Gene symbol	PDZD8	BCAS1
	Gene ID	118987	8537
	Gene name	PDZ domain containing 8	brain enriched myelin associated protein 1
	Synonyms	PDZK8	AIBC1\|NABC1\|PMES-2
	Cytomap	10q25.3-q26.11	20q13.2
	Type of gene	protein-coding	protein-coding
	Description	PDZ domain-containing protein 8sarcoma antigen NY-SAR-84/NY-SAR-104	breast carcinoma-amplified sequence 1amplified and overexpressed in breast cancerbreast carcinoma amplified sequence 1novel amplified in breast cancer 1protein having mRNA enriched in synaptosomes 2
	Modification date	20200313	20200313
	UniProtAcc	.	O75363
	Ensembl transtripts involved in fusion gene	ENST00000334464, ENST00000482496,	ENST00000411563, ENST00000371435, ENST00000371440, ENST00000395961, ENST00000434986,
Fusion gene scores	* DoF score	13 X 9 X 7=819	18 X 14 X 9=2268
	# samples	14	19
	** MAII score	log2(14/819*10)=-2.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2268*10)=-3.57734931661128 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PDZD8 [Title/Abstract] AND BCAS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PDZD8(119078382)-BCAS1(52602038), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PDZD8	GO:0051560	mitochondrial calcium ion homeostasis	29097544
Hgene	PDZD8	GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering	29097544

Fusion gene breakpoints across PDZD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BCAS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OF	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-

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Fusion Gene ORF analysis for PDZD8-BCAS1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000334464	ENST00000411563	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
In-frame	ENST00000334464	ENST00000371435	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
In-frame	ENST00000334464	ENST00000371440	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
In-frame	ENST00000334464	ENST00000395961	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
In-frame	ENST00000334464	ENST00000434986	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
intron-3CDS	ENST00000482496	ENST00000371435	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
intron-3CDS	ENST00000482496	ENST00000371440	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
intron-3CDS	ENST00000482496	ENST00000395961	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
intron-3CDS	ENST00000482496	ENST00000434986	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-
intron-intron	ENST00000482496	ENST00000411563	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000334464	PDZD8	chr10	119078382	-	ENST00000371440	BCAS1	chr20	52602038	-	2121	1338	240	2120	626
ENST00000334464	PDZD8	chr10	119078382	-	ENST00000371435	BCAS1	chr20	52602038	-	3313	1338	240	1931	563
ENST00000334464	PDZD8	chr10	119078382	-	ENST00000395961	BCAS1	chr20	52602038	-	3547	1338	240	2165	641
ENST00000334464	PDZD8	chr10	119078382	-	ENST00000434986	BCAS1	chr20	52602038	-	2189	1338	240	1889	549

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000334464	ENST00000371440	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-	0.006440958	0.99355906
ENST00000334464	ENST00000371435	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-	0.001441858	0.9985581
ENST00000334464	ENST00000395961	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-	0.001178353	0.9988217
ENST00000334464	ENST00000434986	PDZD8	chr10	119078382	-	BCAS1	chr20	52602038	-	0.006550221	0.99344975

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Fusion Genomic Features for PDZD8-BCAS1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDZD8-BCAS1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:119078382/chr20:52602038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BCAS1 O75363
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Required for myelination. {ECO:0000250\|UniProtKB:Q80YN3}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDZD8

chr10:119078382

chr20:52602038

ENST00000334464

91_294

366

1155.0

Domain

SMP-LTD

Hgene

PDZD8

chr10:119078382

chr20:52602038

ENST00000334464

2_24

366

1155.0

Transmembrane

Helical

Tgene

BCAS1

chr10:119078382

chr20:52602038

ENST00000371440

565_584

354

615.0

Region

Interacts with DYNLL1 AND DYNLL2

Tgene

BCAS1

chr10:119078382

chr20:52602038

ENST00000395961

565_584

309

585.0

Region

Interacts with DYNLL1 AND DYNLL2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDZD8

chr10:119078382

chr20:52602038

ENST00000334464

1028_1063

366

1155.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PDZD8

chr10:119078382

chr20:52602038

ENST00000334464

551_626

366

1155.0

Compositional bias

Note=Pro-rich

Hgene

PDZD8

chr10:119078382

chr20:52602038

ENST00000334464

366_449

366

1155.0

Domain

PDZ

Hgene

PDZD8

chr10:119078382

chr20:52602038

ENST00000334464

840_891

366

1155.0

Zinc finger

Phorbol-ester/DAG-type

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Fusion Gene Sequence for PDZD8-BCAS1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64154_64154_1_PDZD8-BCAS1_PDZD8_chr10_119078382_ENST00000334464_BCAS1_chr20_52602038_ENST00000371435_length(transcript)=3313nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGGGTGCTGAAAAG
TCACCCACCACTTCAGCTGACCTTAAGTCAGACAAAGCCAACTTTACATCCCAGGAGACCCAAGGGGCTGGCAAGAATTCCAAAGGATGC
AACCCATCGGGGCACACACAGTCCGTGACAACCCCTGAACCTGCGAAGGAAGGCACCAAGGAGAAATCAGGACCCACCTCTCTGCCTCTG
GGCAAACTGTTTTGGAAAAAGTCAGTTAAAGAGGACTCAGTCCCCACAGGTGCGGAGGAGAATACATCAGACTCCACAGAAAAGACTATC
ACACCGCCAGAGCCTGAACCAACAGGAGCACCACAGAAGGGTAAAGAGGGCTCCTCGAAGGACAAGAAGTCAGCAGCCGAGATGAACAAG
CAGAAGAGCAACAAGCAGGAAGCCAAAGAACCAGCCCAGTGCACAGAGCAGGCCACGGTGGACACGAACTCACTGCAGAATGGGGACAAG
CTCCAAAAGAGACCTGAGAAGCGGCAGCAGTCCCTTGGGGGCTTCTTTAAAGGCCTGGGACCAAAGCGGATGTTGGATGCTCAAGTGCAA
ACAGACCCAGTATCCATCGGACCAGTTGGCAAATCCAAGTAAACAAATCAGCACGGTTCCCACCAGGTTCTCCTGCCACCAAGATGTGTT
CTCCTTACTCCATCTCCTCCCCAAACACGCTCCATGTATATATTCTTCTGATGGCCAGCAAATGAAATTCTGCCTAGAAATTAAGCCCGA
GCTGTTGTATATTGAGGTGTATTATTTACGTCTCTGGTCCAGTCTTTTCTGGCAAATAACAGTAAAGATGGTTTAGCAGGTCACCTAGTT
GGGTCAGAAGAGTCGATGATCACCAAGCAGGAAAGGGAGGGAATAGAGGAATGTGTTCGGGTTAAGTGATGAAAATGGCAGTGGTGGCCG
GGCGTGGTGGCTCTCGCCTGTAATCTCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGACTAGCCTGGCC
AACATCATGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCACACACCTGTAGTCCCAGCTACTCGGGAGCCCAA
CGCACGAGAACCGCTTGTACCCAGGAGGTGGAGGTTGCAGTGAGCCGAAGTTGCACCATTGCACTCCACCCTGGGCGACAGAGCAAGATT
CTATCAAAAAAAAAAAAAGGCAGTGGCAAGTAAGTTATAGAAGAGAAATGCTGCTAGAAGGAATTAAGCGTTGTAGTAAATGCGTGCTTA
TCCTCTAAGCTTGAAGAAGGGAGACGAAAATCCATTTGTTTAAATTCACATCTCAAGGAGGGAGAACCCGGGCTGTGTTGGGTGGTTGCC
AATTTCCTAGAACGGAATGTGTGGGGTATAGAAAAAGGAATGAATAAGCGTTGTTTTTCAAATAGGGTCCTTGTAAGTTATTGATGAGAG
GGAAAAGATTGACTGGGGAGGGCTTAAAATGATTTGGGAAAACAATTGCTTTTGAGGCTCAGTGACAACGGCAAAGATTACAACTTAAAA
AAAAAAAATAAATAAAAAATAAAGGAAGTTGCACGGTTATTTTGCAACACAAGGGGGCGGCAAGGTCCCCATTTTTATCCTGTAATACTG
TATCCCTAACAAAGATTTGGTCTCTGCTATCTTACATTATTAATGTTTCTCAGATGGCTGAGGGGCTCGCTTCATCTGTTCCGTCTGACA
CTTATCTCAAGTGTGTCTGTCATTCCTAATGTTCTCAGGATGTGCTCTGATAAAACCCTCCCCATAACCTCAGTTAATAAAAATTTACAG
AAGACTTCTCAAATACCTGAGTTGTTTTTAATACCTGTACAAAGGAGTAAATAGGACCCTGAGTCTATTAAAATGTAATTCAAAGTAGCA

>64154_64154_1_PDZD8-BCAS1_PDZD8_chr10_119078382_ENST00000334464_BCAS1_chr20_52602038_ENST00000371435_length(amino acids)=563AA_BP=366
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEE
NTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGFFKGLG

--------------------------------------------------------------
>64154_64154_2_PDZD8-BCAS1_PDZD8_chr10_119078382_ENST00000334464_BCAS1_chr20_52602038_ENST00000371440_length(transcript)=2121nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGGGTGCTGAAAAG
TCACCCACCACTTCAGCTGACCTTAAGTCAGACAAAGCCAACTTTACATCCCAGGAGACCCAAGGGGCTGGCAAGAATTCCAAAGGATGC
AACCCATCGGGGCACACACAGTCCGTGACAACCCCTGAACCTGCGAAGGAAGGCACCAAGGAGAAATCAGGACCCACCTCTCTGCCTCTG
GGCAAACTGTTTTGGAAAAAGGTGGTGTGTGAGTCACCAGTAGAGATTATAAAGTCCAAGGAAGTAGAATCAGCCTTACAAACAGTGGAC
CTCAACGAAGGAGATGCTGCACCTGAACCCACAGAAGCGAAACTCAAAAGAGAAGAAAGCAAACCAAGAACCTCTCTGATGGCGTTTCTC
AGACAAATGACATCAGACTCCACAGAAAAGACTATCACACCGCCAGAGCCTGAACCAACAGGAGCACCACAGAAGGGTAAAGAGGGCTCC
TCGAAGGACAAGAAGTCAGCAGCCGAGATGAACAAGCAGAAGAGCAACAAGCAGGAAGCCAAAGAACCAGCCCAGTGCACAGAGCAGGCC
ACGGTGGACACGAACTCACTGCAGAATGGGGACAAGCTCCAAAAGAGACCTGAGAAGCGGCAGCAGTCCCTTGGGGGCTTCTTTAAAGGC
CTGGGACCAAAGCGGATGTTGGATGCTCAAGTGCAAACAGACCCAGTATCCATCGGACCAGTTGGCAAATCCAAGTACACAGGGAAGTGT

>64154_64154_2_PDZD8-BCAS1_PDZD8_chr10_119078382_ENST00000334464_BCAS1_chr20_52602038_ENST00000371440_length(amino acids)=626AA_BP=366
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKVVCESPVEIIKSK
EVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEA

--------------------------------------------------------------
>64154_64154_3_PDZD8-BCAS1_PDZD8_chr10_119078382_ENST00000334464_BCAS1_chr20_52602038_ENST00000395961_length(transcript)=3547nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGGGTGCTGAAAAG
TCACCCACCACTTCAGCTGACCTTAAGTCAGACAAAGCCAACTTTACATCCCAGGAGACCCAAGGGGCTGGCAAGAATTCCAAAGGATGC
AACCCATCGGGGCACACACAGTCCGTGACAACCCCTGAACCTGCGAAGGAAGGCACCAAGGAGAAATCAGGACCCACCTCTCTGCCTCTG
GGCAAACTGTTTTGGAAAAAGTCAGTTAAAGAGGACTCAGTCCCCACAGGTGCGGAGGAGAATGTGGTGTGTGAGTCACCAGTAGAGATT
ATAAAGTCCAAGGAAGTAGAATCAGCCTTACAAACAGTGGACCTCAACGAAGGAGATGCTGCACCTGAACCCACAGAAGCGAAACTCAAA
AGAGAAGAAAGCAAACCAAGAACCTCTCTGATGGCGTTTCTCAGACAAATGTCAGTGAAAGGGGATGGAGGGATCACCCACTCAGAAGAA
ATAAATGGGAAAGACTCCAGCTGCCAAACATCAGACTCCACAGAAAAGACTATCACACCGCCAGAGCCTGAACCAACAGGAGCACCACAG
AAGGGTAAAGAGGGCTCCTCGAAGGACAAGAAGTCAGCAGCCGAGATGAACAAGCAGAAGAGCAACAAGCAGGAAGCCAAAGAACCAGCC
CAGTGCACAGAGCAGGCCACGGTGGACACGAACTCACTGCAGAATGGGGACAAGCTCCAAAAGAGACCTGAGAAGCGGCAGCAGTCCCTT
GGGGGCTTCTTTAAAGGCCTGGGACCAAAGCGGATGTTGGATGCTCAAGTGCAAACAGACCCAGTATCCATCGGACCAGTTGGCAAATCC
AAGTAAACAAATCAGCACGGTTCCCACCAGGTTCTCCTGCCACCAAGATGTGTTCTCCTTACTCCATCTCCTCCCCAAACACGCTCCATG
TATATATTCTTCTGATGGCCAGCAAATGAAATTCTGCCTAGAAATTAAGCCCGAGCTGTTGTATATTGAGGTGTATTATTTACGTCTCTG
GTCCAGTCTTTTCTGGCAAATAACAGTAAAGATGGTTTAGCAGGTCACCTAGTTGGGTCAGAAGAGTCGATGATCACCAAGCAGGAAAGG
GAGGGAATAGAGGAATGTGTTCGGGTTAAGTGATGAAAATGGCAGTGGTGGCCGGGCGTGGTGGCTCTCGCCTGTAATCTCAGCACTTTG
GGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGACTAGCCTGGCCAACATCATGAAACCCCGTCTCTACTAAAAATACAAA
AATTAGCCAGGCATGGTGGCACACACCTGTAGTCCCAGCTACTCGGGAGCCCAACGCACGAGAACCGCTTGTACCCAGGAGGTGGAGGTT
GCAGTGAGCCGAAGTTGCACCATTGCACTCCACCCTGGGCGACAGAGCAAGATTCTATCAAAAAAAAAAAAAGGCAGTGGCAAGTAAGTT
ATAGAAGAGAAATGCTGCTAGAAGGAATTAAGCGTTGTAGTAAATGCGTGCTTATCCTCTAAGCTTGAAGAAGGGAGACGAAAATCCATT
TGTTTAAATTCACATCTCAAGGAGGGAGAACCCGGGCTGTGTTGGGTGGTTGCCAATTTCCTAGAACGGAATGTGTGGGGTATAGAAAAA
GGAATGAATAAGCGTTGTTTTTCAAATAGGGTCCTTGTAAGTTATTGATGAGAGGGAAAAGATTGACTGGGGAGGGCTTAAAATGATTTG
GGAAAACAATTGCTTTTGAGGCTCAGTGACAACGGCAAAGATTACAACTTAAAAAAAAAAAATAAATAAAAAATAAAGGAAGTTGCACGG
TTATTTTGCAACACAAGGGGGCGGCAAGGTCCCCATTTTTATCCTGTAATACTGTATCCCTAACAAAGATTTGGTCTCTGCTATCTTACA
TTATTAATGTTTCTCAGATGGCTGAGGGGCTCGCTTCATCTGTTCCGTCTGACACTTATCTCAAGTGTGTCTGTCATTCCTAATGTTCTC
AGGATGTGCTCTGATAAAACCCTCCCCATAACCTCAGTTAATAAAAATTTACAGAAGACTTCTCAAATACCTGAGTTGTTTTTAATACCT
GTACAAAGGAGTAAATAGGACCCTGAGTCTATTAAAATGTAATTCAAAGTAGCATATGATTGACTGACAGTCATGTAAACTGTATCTTTC

>64154_64154_3_PDZD8-BCAS1_PDZD8_chr10_119078382_ENST00000334464_BCAS1_chr20_52602038_ENST00000395961_length(amino acids)=641AA_BP=366
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEE
NVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITP
PEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTD

--------------------------------------------------------------
>64154_64154_4_PDZD8-BCAS1_PDZD8_chr10_119078382_ENST00000334464_BCAS1_chr20_52602038_ENST00000434986_length(transcript)=2189nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGGGTGCTGAAAAG
TCACCCACCACTTCAGCTGACCTTAAGTCAGACAAAGCCAACTTTACATCCCAGGAGACCCAAGGGGCTGGCAAGAATTCCAAAGGATGC
AACCCATCGGGGCACACACAGTCCGTGACAACCCCTGAACCTGCGAAGGAAGGCACCAAGGAGAAATCAGGACCCACCTCTCTGCCTCTG
GGCAAACTGTTTTGGAAAAAGACATCAGACTCCACAGAAAAGACTATCACACCGCCAGAGCCTGAACCAACAGGAGCACCACAGAAGGGT
AAAGAGGGCTCCTCGAAGGACAAGAAGTCAGCAGCCGAGATGAACAAGCAGAAGAGCAACAAGCAGGAAGCCAAAGAACCAGCCCAGTGC
ACAGAGCAGGCCACGGTGGACACGAACTCACTGCAGAATGGGGACAAGCTCCAAAAGAGACCTGAGAAGCGGCAGCAGTCCCTTGGGGGC
TTCTTTAAAGGCCTGGGACCAAAGCGGATGTTGGATGCTCAAGTGCAAACAGACCCAGTATCCATCGGACCAGTTGGCAAATCCAAGTAA
ACAAATCAGCACGGTTCCCACCAGGTTCTCCTGCCACCAAGATGTGTTCTCCTTACTCCATCTCCTCCCCAAACACGCTCCATGTATATA
TTCTTCTGATGGCCAGCAAATGAAATTCTGCCTAGAAATTAAGCCCGAGCTGTTGTATATTGAGGTGTATTATTTACGTCTCTGGTCCAG
TCTTTTCTGGCAAATAACAGTAAAGATGGTTTAGCAGGTCACCTAGTTGGGTCAGAAGAGTCGATGATCACCAAGCAGGAAAGGGAGGGA

>64154_64154_4_PDZD8-BCAS1_PDZD8_chr10_119078382_ENST00000334464_BCAS1_chr20_52602038_ENST00000434986_length(amino acids)=549AA_BP=366
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKTSDSTEKTITPPE
PEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PDZD8-BCAS1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PDZD8-BCAS1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PDZD8-BCAS1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source