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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDZD8-ENO4 (FusionGDB2 ID:64158)

Fusion Gene Summary for PDZD8-ENO4

check button Fusion gene summary
Fusion gene informationFusion gene name: PDZD8-ENO4
Fusion gene ID: 64158
HgeneTgene
Gene symbol

PDZD8

ENO4

Gene ID

118987

387712

Gene namePDZ domain containing 8enolase 4
SynonymsPDZK8C10orf134
Cytomap

10q25.3-q26.11

10q25.3

Type of geneprotein-codingprotein-coding
DescriptionPDZ domain-containing protein 8sarcoma antigen NY-SAR-84/NY-SAR-104enolase 42-phospho-D-glycerate hydro-lyaseenolase family member 4enolase-like protein ENO4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334464, ENST00000482496, 
ENST00000369207, ENST00000409522, 
ENST00000341276, 
Fusion gene scores* DoF score13 X 9 X 7=8194 X 6 X 2=48
# samples 144
** MAII scorelog2(14/819*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDZD8 [Title/Abstract] AND ENO4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDZD8(119078383)-ENO4(118615134), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDZD8

GO:0051560

mitochondrial calcium ion homeostasis

29097544

HgenePDZD8

GO:1990456

mitochondrion-endoplasmic reticulum membrane tethering

29097544


check buttonFusion gene breakpoints across PDZD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ENO4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-DA-A1I8-06APDZD8chr10

119078383

-ENO4chr10

118615134

+
ChimerDB4SKCMTCGA-DA-A1I8-06APDZD8chr10

119078383

-ENO4chr10

118616003

+
ChimerDB4SKCMTCGA-DA-A1I8-06APDZD8chr10

119078383

-ENO4chr10

118628161

+


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Fusion Gene ORF analysis for PDZD8-ENO4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334464ENST00000369207PDZD8chr10

119078383

-ENO4chr10

118615134

+
5CDS-intronENST00000334464ENST00000369207PDZD8chr10

119078383

-ENO4chr10

118616003

+
5CDS-intronENST00000334464ENST00000409522PDZD8chr10

119078383

-ENO4chr10

118615134

+
5CDS-intronENST00000334464ENST00000409522PDZD8chr10

119078383

-ENO4chr10

118616003

+
In-frameENST00000334464ENST00000341276PDZD8chr10

119078383

-ENO4chr10

118615134

+
In-frameENST00000334464ENST00000341276PDZD8chr10

119078383

-ENO4chr10

118616003

+
In-frameENST00000334464ENST00000341276PDZD8chr10

119078383

-ENO4chr10

118628161

+
In-frameENST00000334464ENST00000369207PDZD8chr10

119078383

-ENO4chr10

118628161

+
In-frameENST00000334464ENST00000409522PDZD8chr10

119078383

-ENO4chr10

118628161

+
intron-3CDSENST00000482496ENST00000341276PDZD8chr10

119078383

-ENO4chr10

118615134

+
intron-3CDSENST00000482496ENST00000341276PDZD8chr10

119078383

-ENO4chr10

118616003

+
intron-3CDSENST00000482496ENST00000341276PDZD8chr10

119078383

-ENO4chr10

118628161

+
intron-3CDSENST00000482496ENST00000369207PDZD8chr10

119078383

-ENO4chr10

118628161

+
intron-3CDSENST00000482496ENST00000409522PDZD8chr10

119078383

-ENO4chr10

118628161

+
intron-intronENST00000482496ENST00000369207PDZD8chr10

119078383

-ENO4chr10

118615134

+
intron-intronENST00000482496ENST00000369207PDZD8chr10

119078383

-ENO4chr10

118616003

+
intron-intronENST00000482496ENST00000409522PDZD8chr10

119078383

-ENO4chr10

118615134

+
intron-intronENST00000482496ENST00000409522PDZD8chr10

119078383

-ENO4chr10

118616003

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334464PDZD8chr10119078383-ENST00000341276ENO4chr10118615134+389413382403056938
ENST00000334464PDZD8chr10119078383-ENST00000341276ENO4chr10118616003+376513382402927895
ENST00000334464PDZD8chr10119078383-ENST00000341276ENO4chr10118628161+306313382402225661
ENST00000334464PDZD8chr10119078383-ENST00000409522ENO4chr10118628161+295813382402099619
ENST00000334464PDZD8chr10119078383-ENST00000369207ENO4chr10118628161+236113382402144634

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334464ENST00000341276PDZD8chr10119078383-ENO4chr10118615134+0.0004793470.99952066
ENST00000334464ENST00000341276PDZD8chr10119078383-ENO4chr10118616003+0.0005853110.9994147
ENST00000334464ENST00000341276PDZD8chr10119078383-ENO4chr10118628161+0.0011435160.99885654
ENST00000334464ENST00000409522PDZD8chr10119078383-ENO4chr10118628161+0.0009569120.99904305
ENST00000334464ENST00000369207PDZD8chr10119078383-ENO4chr10118628161+0.0017296450.9982704

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Fusion Genomic Features for PDZD8-ENO4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDZD8chr10119078382-ENO4chr10118628160+7.44E-050.9999256
PDZD8chr10119078382-ENO4chr10118615133+1.55E-060.99999845
PDZD8chr10119078382-ENO4chr10118616002+4.64E-070.9999995
PDZD8chr10119078382-ENO4chr10118628160+7.44E-050.9999256
PDZD8chr10119078382-ENO4chr10118615133+1.55E-060.99999845
PDZD8chr10119078382-ENO4chr10118616002+4.64E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PDZD8-ENO4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:119078383/chr10:118615134)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDZD8chr10:119078383chr10:118615134ENST00000334464-3591_2943661155.0DomainSMP-LTD
HgenePDZD8chr10:119078383chr10:118616003ENST00000334464-3591_2943661155.0DomainSMP-LTD
HgenePDZD8chr10:119078383chr10:118628161ENST00000334464-3591_2943661155.0DomainSMP-LTD
HgenePDZD8chr10:119078383chr10:118615134ENST00000334464-352_243661155.0TransmembraneHelical
HgenePDZD8chr10:119078383chr10:118616003ENST00000334464-352_243661155.0TransmembraneHelical
HgenePDZD8chr10:119078383chr10:118628161ENST00000334464-352_243661155.0TransmembraneHelical
TgeneENO4chr10:119078383chr10:118615134ENST0000040952207189_2310309.0Compositional biasNote=Pro-rich
TgeneENO4chr10:119078383chr10:118616003ENST0000040952207189_2310309.0Compositional biasNote=Pro-rich
TgeneENO4chr10:119078383chr10:118628161ENST0000040952207189_23155309.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDZD8chr10:119078383chr10:118615134ENST00000334464-351028_10633661155.0Coiled coilOntology_term=ECO:0000255
HgenePDZD8chr10:119078383chr10:118616003ENST00000334464-351028_10633661155.0Coiled coilOntology_term=ECO:0000255
HgenePDZD8chr10:119078383chr10:118628161ENST00000334464-351028_10633661155.0Coiled coilOntology_term=ECO:0000255
HgenePDZD8chr10:119078383chr10:118615134ENST00000334464-35551_6263661155.0Compositional biasNote=Pro-rich
HgenePDZD8chr10:119078383chr10:118616003ENST00000334464-35551_6263661155.0Compositional biasNote=Pro-rich
HgenePDZD8chr10:119078383chr10:118628161ENST00000334464-35551_6263661155.0Compositional biasNote=Pro-rich
HgenePDZD8chr10:119078383chr10:118615134ENST00000334464-35366_4493661155.0DomainPDZ
HgenePDZD8chr10:119078383chr10:118616003ENST00000334464-35366_4493661155.0DomainPDZ
HgenePDZD8chr10:119078383chr10:118628161ENST00000334464-35366_4493661155.0DomainPDZ
HgenePDZD8chr10:119078383chr10:118615134ENST00000334464-35840_8913661155.0Zinc fingerPhorbol-ester/DAG-type
HgenePDZD8chr10:119078383chr10:118616003ENST00000334464-35840_8913661155.0Zinc fingerPhorbol-ester/DAG-type
HgenePDZD8chr10:119078383chr10:118628161ENST00000334464-35840_8913661155.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for PDZD8-ENO4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64158_64158_1_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118615134_ENST00000341276_length(transcript)=3894nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGGCAAACTGCTTT
TCTAAACTTGCAAAGCCTCCCACCATATGCAAAATAGTGGGGAAAGACGTACTAGATGGACTGGGGCTTCCAACCCTGCAAGTGGACATA
TTCTGCACCATTCAAAACTTTCCCAAGAACGTATGTTCTGTGGTGATCTCGACTCATTTTGAAGTCCATGAGAATGCTCTGCCCGAGCTG
GCCAAGGCGGAGGAGGCAGAGAGGGCCAGCGCGGTGAGCACCGCCGTGCAGTGGGTCAACAGCACCATCACGCACGAGCTCCAGGGGATG
GCACCCTCTGACCAGGCAGAGGTGGATCACCTACTCAGGATATTCTTCGCAAGTAAAGTACAAGAAGATAAGGGGAGAAAAGAATTGGAA
AAGAGCCTGGAATACTCAACAGTGCCTACACCTCTACCTCCAGTACCACCACCACCACCCCCTCCACCTCCTACCAAAAAAAAGGGGCAA
AAGCCAGGGAGGAAGGATACTATTACAGAGAAACCTATTGCGCCTGCAGAGCCTGTTGAGCCTGTACTCAGTGGCAGTATGGCCATAGGG
GCCGTGTCACTAGCTGTTGCCAAAGCCTGTGCCATGCTGCTTAATAAACCTCTGTACTTAAATATCGCTCTACTGAAGCACAATCAGGAA
CAGCCAACAACGCTATCTATGCCTTTGCTGATGGTATCGCTGGTCAGCTGTGGGAAGTCATCATCTGGGAAGCTAAATTTAATGAAAGAA
GTGATTTGTATACCCCATCCTGAATTAACAACCAAACAAGGTGTCGAGATGCTTATGGAAATGCAGAAACATATCAACAAAATAATTGAA
ATGGTATCACCCTCTCCTCCAAAAGCAGAGACAAAAAAAGGGCACGATGGAAGCAAAAGAGGTCAACAGCAGATCACTGGCAAGATGTCT
CATCTTGGCTGTTTAACCATTAACTGTGACTCCATAGAACAGCCACTGCTTCTAATACAGGAAATCTGTGCCAACCTGGGGCTAGAACTG
GGAACAAATCTGCATCTAGCTATCAACTGTGCTGGACATGAGCTGATGGACTACAATAAAGGAAAGTATGAAGTGATCATGGGCACATAC
AAAAATGCAGCGGAGATGGTTGACCTGTATGTGGATCTGATCAACAAGTACCCTTCAATTATTGCCTTAATTGATCCTTTCAGGAAGGAG
GACTCTGAACAGTGGGACAGCATCTATCACGCACTTGGTTCCAGGTGTTACATAATTGCAGGAACTGCTTCCAAAAGCATTTCTAAACTT
CTAGAGCAAGGAAACATCAGCATCCCCAAATCCAATGGGCTGATCATAAAACACACAAACCAAACTACAATGTCTGACTTGGTGGAAATA
ACCAATCTGATTGACAGTAAGAAGCACATCACTGTCTTTGGAAGTACAGAAGGAGAATCATCTGATGACAGCCTTGTCGATTTGGCTGTT
GGGCTTGGTGTCCGGTTCATCAAGTTGGGGGGTCTTTCCCGTGGTGAACGAGTGACTAAATACAACCGCCTTCTCACTATAGAGGAAGAA
CTTGTCCAGAATGGAACACTGGGTTTCAAAGAAGAACACACTTTTTTTTACTTTAATGAGGAAGCTGAAAAGGCTGCGGAGGCACTTGAG
GCTGCTGCGGCTAGGGAGCCGCTGGTGCCCACCTTCCCCACACAAGGTGTAGAGGAATCAGCCGAAACAGGAGCATCCTCTGGATAGGGC
TGTACACACCCCAGGTTCCAGCCACACCATCAGTATTAGTAGACCGGGAGGTCTGAAGTACGGCGCCGTGTCTCCACATGGAGTTTCCTC
TTCAACTTCACCAACTCTTGTGGTTTTTATTCTTCTAATTCCACTGTTTGGTAAATTACATATATGATGTTTTTGCCTGAAATTCTGTGA
ACTTCGTTTTGCAGCCACCACACTTCCATGTGGATTTTGTTTGTCTATTAGCTCTCCTGTCCATTTTTCAGGGACACGCTCCAGTAAAAG
AGGCCAATATTTTTGTTGCCAACTCCACACTCAGTCAAACACCCCATCCTTTACCAATCAGAATATCTCTGAGAACAAAAACCTAATGAC
CCTAGAAGCTCTCTGTGCTGGGAACAGATGTCCATCTTCTGTGTTTATTCTACATGTCTGTGCTGAAAAGCACTGACACATTTTTGTAAC
CAACCTCACGTAGAAGTGTGAGAGCATCACCATTTTTTGTAAGAGCCAATTTCATCTCACTTTCCTACCCTTGATTCCTTTTTTCCTAAT
TCCCTCTCCTTTTTAAATTTTAGTTTTTCTTGTATTATTTTTATCTTTGCGAGTCTTCTTAGATCCTTTTTGGAGTAAGAATGAGTATAA
ATGAATAAGCACATCAGTAAATGAATTAATATTCTCAAGGTTATTAAATGCCCAGTTATTCATACCACAGCATTTAAAAAGCAATCCGCA
AGTGATAAAAAAAAAAAAAAAAAATGATGTGACATATCCATTGCCTGAATTGCTCTTTTGTAAGCCAGTGTTGGGATTATAGCAGAGGAG

>64158_64158_1_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118615134_ENST00000341276_length(amino acids)=938AA_BP=366
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTANCFSKLAKPPTICKIVGKDVLDGLGLPTLQVDIFCTIQNFPKNVCSVVISTHFEVHENALPELAKAEEAERASAVSTAVQWVN
STITHELQGMAPSDQAEVDHLLRIFFASKVQEDKGRKELEKSLEYSTVPTPLPPVPPPPPPPPPTKKKGQKPGRKDTITEKPIAPAEPVE
PVLSGSMAIGAVSLAVAKACAMLLNKPLYLNIALLKHNQEQPTTLSMPLLMVSLVSCGKSSSGKLNLMKEVICIPHPELTTKQGVEMLME
MQKHINKIIEMVSPSPPKAETKKGHDGSKRGQQQITGKMSHLGCLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYNK
GKYEVIMGTYKNAAEMVDLYVDLINKYPSIIALIDPFRKEDSEQWDSIYHALGSRCYIIAGTASKSISKLLEQGNISIPKSNGLIIKHTN
QTTMSDLVEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLGVRFIKLGGLSRGERVTKYNRLLTIEEELVQNGTLGFKEEHTFFYFNE

--------------------------------------------------------------
>64158_64158_2_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118616003_ENST00000341276_length(transcript)=3765nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGAACGTATGTTCT
GTGGTGATCTCGACTCATTTTGAAGTCCATGAGAATGCTCTGCCCGAGCTGGCCAAGGCGGAGGAGGCAGAGAGGGCCAGCGCGGTGAGC
ACCGCCGTGCAGTGGGTCAACAGCACCATCACGCACGAGCTCCAGGGGATGGCACCCTCTGACCAGGCAGAGGTGGATCACCTACTCAGG
ATATTCTTCGCAAGTAAAGTACAAGAAGATAAGGGGAGAAAAGAATTGGAAAAGAGCCTGGAATACTCAACAGTGCCTACACCTCTACCT
CCAGTACCACCACCACCACCCCCTCCACCTCCTACCAAAAAAAAGGGGCAAAAGCCAGGGAGGAAGGATACTATTACAGAGAAACCTATT
GCGCCTGCAGAGCCTGTTGAGCCTGTACTCAGTGGCAGTATGGCCATAGGGGCCGTGTCACTAGCTGTTGCCAAAGCCTGTGCCATGCTG
CTTAATAAACCTCTGTACTTAAATATCGCTCTACTGAAGCACAATCAGGAACAGCCAACAACGCTATCTATGCCTTTGCTGATGGTATCG
CTGGTCAGCTGTGGGAAGTCATCATCTGGGAAGCTAAATTTAATGAAAGAAGTGATTTGTATACCCCATCCTGAATTAACAACCAAACAA
GGTGTCGAGATGCTTATGGAAATGCAGAAACATATCAACAAAATAATTGAAATGGTATCACCCTCTCCTCCAAAAGCAGAGACAAAAAAA
GGGCACGATGGAAGCAAAAGAGGTCAACAGCAGATCACTGGCAAGATGTCTCATCTTGGCTGTTTAACCATTAACTGTGACTCCATAGAA
CAGCCACTGCTTCTAATACAGGAAATCTGTGCCAACCTGGGGCTAGAACTGGGAACAAATCTGCATCTAGCTATCAACTGTGCTGGACAT
GAGCTGATGGACTACAATAAAGGAAAGTATGAAGTGATCATGGGCACATACAAAAATGCAGCGGAGATGGTTGACCTGTATGTGGATCTG
ATCAACAAGTACCCTTCAATTATTGCCTTAATTGATCCTTTCAGGAAGGAGGACTCTGAACAGTGGGACAGCATCTATCACGCACTTGGT
TCCAGGTGTTACATAATTGCAGGAACTGCTTCCAAAAGCATTTCTAAACTTCTAGAGCAAGGAAACATCAGCATCCCCAAATCCAATGGG
CTGATCATAAAACACACAAACCAAACTACAATGTCTGACTTGGTGGAAATAACCAATCTGATTGACAGTAAGAAGCACATCACTGTCTTT
GGAAGTACAGAAGGAGAATCATCTGATGACAGCCTTGTCGATTTGGCTGTTGGGCTTGGTGTCCGGTTCATCAAGTTGGGGGGTCTTTCC
CGTGGTGAACGAGTGACTAAATACAACCGCCTTCTCACTATAGAGGAAGAACTTGTCCAGAATGGAACACTGGGTTTCAAAGAAGAACAC
ACTTTTTTTTACTTTAATGAGGAAGCTGAAAAGGCTGCGGAGGCACTTGAGGCTGCTGCGGCTAGGGAGCCGCTGGTGCCCACCTTCCCC
ACACAAGGTGTAGAGGAATCAGCCGAAACAGGAGCATCCTCTGGATAGGGCTGTACACACCCCAGGTTCCAGCCACACCATCAGTATTAG
TAGACCGGGAGGTCTGAAGTACGGCGCCGTGTCTCCACATGGAGTTTCCTCTTCAACTTCACCAACTCTTGTGGTTTTTATTCTTCTAAT
TCCACTGTTTGGTAAATTACATATATGATGTTTTTGCCTGAAATTCTGTGAACTTCGTTTTGCAGCCACCACACTTCCATGTGGATTTTG
TTTGTCTATTAGCTCTCCTGTCCATTTTTCAGGGACACGCTCCAGTAAAAGAGGCCAATATTTTTGTTGCCAACTCCACACTCAGTCAAA
CACCCCATCCTTTACCAATCAGAATATCTCTGAGAACAAAAACCTAATGACCCTAGAAGCTCTCTGTGCTGGGAACAGATGTCCATCTTC
TGTGTTTATTCTACATGTCTGTGCTGAAAAGCACTGACACATTTTTGTAACCAACCTCACGTAGAAGTGTGAGAGCATCACCATTTTTTG
TAAGAGCCAATTTCATCTCACTTTCCTACCCTTGATTCCTTTTTTCCTAATTCCCTCTCCTTTTTAAATTTTAGTTTTTCTTGTATTATT
TTTATCTTTGCGAGTCTTCTTAGATCCTTTTTGGAGTAAGAATGAGTATAAATGAATAAGCACATCAGTAAATGAATTAATATTCTCAAG
GTTATTAAATGCCCAGTTATTCATACCACAGCATTTAAAAAGCAATCCGCAAGTGATAAAAAAAAAAAAAAAAAATGATGTGACATATCC

>64158_64158_2_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118616003_ENST00000341276_length(amino acids)=895AA_BP=366
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTNVCSVVISTHFEVHENALPELAKAEEAERASAVSTAVQWVNSTITHELQGMAPSDQAEVDHLLRIFFASKVQEDKGRKELEKSL
EYSTVPTPLPPVPPPPPPPPPTKKKGQKPGRKDTITEKPIAPAEPVEPVLSGSMAIGAVSLAVAKACAMLLNKPLYLNIALLKHNQEQPT
TLSMPLLMVSLVSCGKSSSGKLNLMKEVICIPHPELTTKQGVEMLMEMQKHINKIIEMVSPSPPKAETKKGHDGSKRGQQQITGKMSHLG
CLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYNKGKYEVIMGTYKNAAEMVDLYVDLINKYPSIIALIDPFRKEDSE
QWDSIYHALGSRCYIIAGTASKSISKLLEQGNISIPKSNGLIIKHTNQTTMSDLVEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLG

--------------------------------------------------------------
>64158_64158_3_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118628161_ENST00000341276_length(transcript)=3063nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGCCCTCTCCTCCA
AAAGCAGAGACAAAAAAAGGGCACGATGGAAGCAAAAGAGGTCAACAGCAGATCACTGGCAAGATGTCTCATCTTGGCTGTTTAACCATT
AACTGTGACTCCATAGAACAGCCACTGCTTCTAATACAGGAAATCTGTGCCAACCTGGGGCTAGAACTGGGAACAAATCTGCATCTAGCT
ATCAACTGTGCTGGACATGAGCTGATGGACTACAATAAAGGAAAGTATGAAGTGATCATGGGCACATACAAAAATGCAGCGGAGATGGTT
GACCTGTATGTGGATCTGATCAACAAGTACCCTTCAATTATTGCCTTAATTGATCCTTTCAGGAAGGAGGACTCTGAACAGTGGGACAGC
ATCTATCACGCACTTGGTTCCAGGTGTTACATAATTGCAGGAACTGCTTCCAAAAGCATTTCTAAACTTCTAGAGCAAGGAAACATCAGC
ATCCCCAAATCCAATGGGCTGATCATAAAACACACAAACCAAACTACAATGTCTGACTTGGTGGAAATAACCAATCTGATTGACAGTAAG
AAGCACATCACTGTCTTTGGAAGTACAGAAGGAGAATCATCTGATGACAGCCTTGTCGATTTGGCTGTTGGGCTTGGTGTCCGGTTCATC
AAGTTGGGGGGTCTTTCCCGTGGTGAACGAGTGACTAAATACAACCGCCTTCTCACTATAGAGGAAGAACTTGTCCAGAATGGAACACTG
GGTTTCAAAGAAGAACACACTTTTTTTTACTTTAATGAGGAAGCTGAAAAGGCTGCGGAGGCACTTGAGGCTGCTGCGGCTAGGGAGCCG
CTGGTGCCCACCTTCCCCACACAAGGTGTAGAGGAATCAGCCGAAACAGGAGCATCCTCTGGATAGGGCTGTACACACCCCAGGTTCCAG
CCACACCATCAGTATTAGTAGACCGGGAGGTCTGAAGTACGGCGCCGTGTCTCCACATGGAGTTTCCTCTTCAACTTCACCAACTCTTGT
GGTTTTTATTCTTCTAATTCCACTGTTTGGTAAATTACATATATGATGTTTTTGCCTGAAATTCTGTGAACTTCGTTTTGCAGCCACCAC
ACTTCCATGTGGATTTTGTTTGTCTATTAGCTCTCCTGTCCATTTTTCAGGGACACGCTCCAGTAAAAGAGGCCAATATTTTTGTTGCCA
ACTCCACACTCAGTCAAACACCCCATCCTTTACCAATCAGAATATCTCTGAGAACAAAAACCTAATGACCCTAGAAGCTCTCTGTGCTGG
GAACAGATGTCCATCTTCTGTGTTTATTCTACATGTCTGTGCTGAAAAGCACTGACACATTTTTGTAACCAACCTCACGTAGAAGTGTGA
GAGCATCACCATTTTTTGTAAGAGCCAATTTCATCTCACTTTCCTACCCTTGATTCCTTTTTTCCTAATTCCCTCTCCTTTTTAAATTTT
AGTTTTTCTTGTATTATTTTTATCTTTGCGAGTCTTCTTAGATCCTTTTTGGAGTAAGAATGAGTATAAATGAATAAGCACATCAGTAAA
TGAATTAATATTCTCAAGGTTATTAAATGCCCAGTTATTCATACCACAGCATTTAAAAAGCAATCCGCAAGTGATAAAAAAAAAAAAAAA
AAATGATGTGACATATCCATTGCCTGAATTGCTCTTTTGTAAGCCAGTGTTGGGATTATAGCAGAGGAGTAGCAGAAATAAATATATTCA

>64158_64158_3_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118628161_ENST00000341276_length(amino acids)=661AA_BP=361
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTPSPPKAETKKGHDGSKRGQQQITGKMSHLGCLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYNKGKYEVIM
GTYKNAAEMVDLYVDLINKYPSIIALIDPFRKEDSEQWDSIYHALGSRCYIIAGTASKSISKLLEQGNISIPKSNGLIIKHTNQTTMSDL
VEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLGVRFIKLGGLSRGERVTKYNRLLTIEEELVQNGTLGFKEEHTFFYFNEEAEKAAE

--------------------------------------------------------------
>64158_64158_4_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118628161_ENST00000369207_length(transcript)=2361nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGCCCTCTCCTCCA
AAAGCAGAGACAAAAAAAGGGCACGATGGAAGCAAAAGAGGTCAACAGCAGATCACTGGCAAGATGTCTCATCTTGGCTGTTTAACCATT
AACTGTGACTCCATAGAACAGCCACTGCTTCTAATACAGGAAATCTGTGCCAACCTGGGGCTAGAACTGGGAACAAATCTGCATCTAGCT
ATCAACTGTGCTGGACATGAGCTGATGGACTACAATAAAGGAAAGTATGAAGTGATCATGGGCACATACAAAAATGCAGCGGAGATGGTT
GACCTGTATGTGGATCTGATCAACAAGTACCCTTCAATTATTGCCTTAATTGATCCTTTCAGGAAGGAGGACTCTGAACAGTGGGACAGC
ATCTATCACGCACTTGGTTCCAGGTGTTACATAATTGCAGGAACTGCTTCCAAAAGCATTTCTAAACTTCTAGAGCAAGGAAACATCAGC
ATCCCCAAATCCAATGGGCTGATCATAAAACACACAAACCAAACTACAATGTCTGACTTGGTGGAAATAACCAATCTGATTGACAGTAAG
AAGCACATCACTGTCTTTGGAAGTACAGAAGGAGAATCATCTGATGACAGCCTTGTCGATTTGGCTGTTGGGCTTGGTGTCCGGTTCATC
AAGTTGGGGGGTCTTTCCCGTGGTGAACGAGTGACTAAATACAACCGCCTTCTCACTATAGAGGAAGAACTTGTCCAGAATGGAACACTG
GCCACTTCATCTTCAAGCTGTGATGCCAGGATTGGAGGGCAAGAACAGGAAACAATGACTTTGGTGAAAGTGTAACCACTCTTTTAGAAC
AAAAACAGCACAGTGTTATTTGAAAAATTATTAACATATGTGATGGAGCAGTCTGTAAGCACGATCAAATAAACTGGCCAAAGATGAGGC
TAATTGTAAATGGGAATAAAACACACCACAAACAATTCACAAAAAACAGATTTTAAAATACTCTCCTTTCATTTCCCCATTAGCTAAACA

>64158_64158_4_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118628161_ENST00000369207_length(amino acids)=634AA_BP=361
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTPSPPKAETKKGHDGSKRGQQQITGKMSHLGCLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYNKGKYEVIM
GTYKNAAEMVDLYVDLINKYPSIIALIDPFRKEDSEQWDSIYHALGSRCYIIAGTASKSISKLLEQGNISIPKSNGLIIKHTNQTTMSDL
VEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLGVRFIKLGGLSRGERVTKYNRLLTIEEELVQNGTLATSSSSCDARIGGQEQETMT

--------------------------------------------------------------
>64158_64158_5_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118628161_ENST00000409522_length(transcript)=2958nt_BP=1338nt
GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC
GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG
GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG
GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC
GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC
GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC
ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG
CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC
CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG
GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC
AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG
ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG
CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT
ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC
AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGCCCTCTCCTCCA
AAAGCAGAGACAAAAAAAGGGCACGATGGAAGCAAAAGAGGTCAACAGCAGATCACTGGCAAGATGTCTCATCTTGGCTGTTTAACCATT
AACTGTGACTCCATAGAACAGCCACTGCTTCTAATACAGGAAATCTGTGCCAACCTGGGGCTAGAACTGGGAACAAATCTGCATCTAGCT
ATCAACTGTGCTGGACATGAGCTGATGGACTACGACTCTGAACAGTGGGACAGCATCTATCACGCACTTGGTTCCAGGTGTTACATAATT
GCAGGAACTGCTTCCAAAAGCATTTCTAAACTTCTAGAGCAAGGAAACATCAGCATCCCCAAATCCAATGGGCTGATCATAAAACACACA
AACCAAACTACAATGTCTGACTTGGTGGAAATAACCAATCTGATTGACAGTAAGAAGCACATCACTGTCTTTGGAAGTACAGAAGGAGAA
TCATCTGATGACAGCCTTGTCGATTTGGCTGTTGGGCTTGGTGTCCGGTTCATCAAGTTGGGGGGTCTTTCCCGTGGTGAACGAGTGACT
AAATACAACCGCCTTCTCACTATAGAGGAAGAACTTGTCCAGAATGGAACACTGGGTTTCAAAGAAGAACACACTTTTTTTTACTTTAAT
GAGGAAGCTGAAAAGGCTGCGGAGGCACTTGAGGCTGCTGCGGCTAGGGAGCCGCTGGTGCCCACCTTCCCCACACAAGGTGTAGAGGAA
TCAGCCGAAACAGGAGCATCCTCTGGATAGGGCTGTACACACCCCAGGTTCCAGCCACACCATCAGTATTAGTAGACCGGGAGGTCTGAA
GTACGGCGCCGTGTCTCCACATGGAGTTTCCTCTTCAACTTCACCAACTCTTGTGGTTTTTATTCTTCTAATTCCACTGTTTGGTAAATT
ACATATATGATGTTTTTGCCTGAAATTCTGTGAACTTCGTTTTGCAGCCACCACACTTCCATGTGGATTTTGTTTGTCTATTAGCTCTCC
TGTCCATTTTTCAGGGACACGCTCCAGTAAAAGAGGCCAATATTTTTGTTGCCAACTCCACACTCAGTCAAACACCCCATCCTTTACCAA
TCAGAATATCTCTGAGAACAAAAACCTAATGACCCTAGAAGCTCTCTGTGCTGGGAACAGATGTCCATCTTCTGTGTTTATTCTACATGT
CTGTGCTGAAAAGCACTGACACATTTTTGTAACCAACCTCACGTAGAAGTGTGAGAGCATCACCATTTTTTGTAAGAGCCAATTTCATCT
CACTTTCCTACCCTTGATTCCTTTTTTCCTAATTCCCTCTCCTTTTTAAATTTTAGTTTTTCTTGTATTATTTTTATCTTTGCGAGTCTT
CTTAGATCCTTTTTGGAGTAAGAATGAGTATAAATGAATAAGCACATCAGTAAATGAATTAATATTCTCAAGGTTATTAAATGCCCAGTT
ATTCATACCACAGCATTTAAAAAGCAATCCGCAAGTGATAAAAAAAAAAAAAAAAAATGATGTGACATATCCATTGCCTGAATTGCTCTT

>64158_64158_5_PDZD8-ENO4_PDZD8_chr10_119078383_ENST00000334464_ENO4_chr10_118628161_ENST00000409522_length(amino acids)=619AA_BP=361
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP
TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI
IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTPSPPKAETKKGHDGSKRGQQQITGKMSHLGCLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYDSEQWDSIY
HALGSRCYIIAGTASKSISKLLEQGNISIPKSNGLIIKHTNQTTMSDLVEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLGVRFIKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDZD8-ENO4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDZD8-ENO4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDZD8-ENO4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource