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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PEAK1-PSTPIP1 (FusionGDB2 ID:64203)

Fusion Gene Summary for PEAK1-PSTPIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PEAK1-PSTPIP1
Fusion gene ID: 64203
HgeneTgene
Gene symbol

PEAK1

PSTPIP1

Gene ID

79834

9051

Gene namepseudopodium enriched atypical kinase 1proline-serine-threonine phosphatase interacting protein 1
SynonymsSGK269CD2BP1|CD2BP1L|CD2BP1S|H-PIP|PAPAS|PSTPIP
Cytomap

15q24.3

15q24.3

Type of geneprotein-codingprotein-coding
Descriptioninactive tyrosine-protein kinase PEAK1NKF3 kinase family membersugen kinase 269tyrosine-protein kinase SgK269proline-serine-threonine phosphatase-interacting protein 1CD2 antigen-binding protein 1CD2 cytoplasmic tail-binding proteinCD2-binding protein 1PEST phosphatase-interacting protein 1truncated proline-serine-threonine phosphatase interacting protein 1
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000312493, ENST00000560626, 
ENST00000558305, ENST00000567337, 
ENST00000557995, ENST00000267939, 
ENST00000379595, ENST00000558012, 
ENST00000559295, 
Fusion gene scores* DoF score20 X 14 X 12=33603 X 3 X 2=18
# samples 223
** MAII scorelog2(22/3360*10)=-3.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PEAK1 [Title/Abstract] AND PSTPIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPEAK1(77471132)-PSTPIP1(77317625), # samples:2
Anticipated loss of major functional domain due to fusion event.PEAK1-PSTPIP1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePEAK1

GO:0016477

cell migration

20534451

HgenePEAK1

GO:0034446

substrate adhesion-dependent cell spreading

20534451

HgenePEAK1

GO:0046777

protein autophosphorylation

20534451

HgenePEAK1

GO:0051893

regulation of focal adhesion assembly

23105102


check buttonFusion gene breakpoints across PEAK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSTPIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-DA-A3F5-06APEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
ChimerDB4SKCMTCGA-DA-A3F5-06APEAK1chr15

77712348

-PSTPIP1chr15

77317625

+


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Fusion Gene ORF analysis for PEAK1-PSTPIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000312493ENST00000557995PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
5CDS-intronENST00000560626ENST00000557995PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000558305ENST00000267939PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000558305ENST00000379595PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000558305ENST00000558012PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000558305ENST00000559295PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000560626ENST00000267939PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000560626ENST00000379595PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000560626ENST00000558012PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000560626ENST00000559295PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000567337ENST00000267939PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000567337ENST00000379595PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000567337ENST00000558012PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-3CDSENST00000567337ENST00000559295PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-intronENST00000558305ENST00000557995PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-intronENST00000560626ENST00000557995PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
5UTR-intronENST00000567337ENST00000557995PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
Frame-shiftENST00000560626ENST00000267939PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
Frame-shiftENST00000560626ENST00000379595PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
Frame-shiftENST00000560626ENST00000558012PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
Frame-shiftENST00000560626ENST00000559295PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
In-frameENST00000312493ENST00000267939PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
In-frameENST00000312493ENST00000379595PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
In-frameENST00000312493ENST00000558012PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
In-frameENST00000312493ENST00000559295PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000312493ENST00000267939PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000312493ENST00000379595PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000312493ENST00000558012PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000312493ENST00000559295PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000558305ENST00000267939PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000558305ENST00000379595PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000558305ENST00000558012PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000558305ENST00000559295PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000567337ENST00000267939PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000567337ENST00000379595PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000567337ENST00000558012PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-3CDSENST00000567337ENST00000559295PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-intronENST00000312493ENST00000557995PEAK1chr15

77712348

-PSTPIP1chr15

77317625

+
intron-intronENST00000558305ENST00000557995PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+
intron-intronENST00000567337ENST00000557995PEAK1chr15

77471132

-PSTPIP1chr15

77317625

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312493PEAK1chr1577471132-ENST00000558012PSTPIP1chr1577317625+4611341627944541391
ENST00000312493PEAK1chr1577471132-ENST00000267939PSTPIP1chr1577317625+4552341627943971372
ENST00000312493PEAK1chr1577471132-ENST00000379595PSTPIP1chr1577317625+4601341627944451388
ENST00000312493PEAK1chr1577471132-ENST00000559295PSTPIP1chr1577317625+4553341627943971372

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312493ENST00000558012PEAK1chr1577471132-PSTPIP1chr1577317625+0.0014373210.99856275
ENST00000312493ENST00000267939PEAK1chr1577471132-PSTPIP1chr1577317625+0.0014633870.9985366
ENST00000312493ENST00000379595PEAK1chr1577471132-PSTPIP1chr1577317625+0.0010556490.99894434
ENST00000312493ENST00000559295PEAK1chr1577471132-PSTPIP1chr1577317625+0.0014604030.99853957

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Fusion Genomic Features for PEAK1-PSTPIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PEAK1chr1577471131-PSTPIP1chr1577317624+0.99988010.000119941
PEAK1chr1577712347-PSTPIP1chr1577317624+0.0187641210.98123586
PEAK1chr1577471131-PSTPIP1chr1577317624+0.99988010.000119941
PEAK1chr1577712347-PSTPIP1chr1577317624+0.0187641210.98123586

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PEAK1-PSTPIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:77471132/chr15:77317625)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePEAK1chr15:77471132chr15:77317625ENST00000312493-25117_12010451747.0Compositional biasNote=Poly-Asn
HgenePEAK1chr15:77471132chr15:77317625ENST00000312493-25324_40610451747.0Compositional biasNote=Ser-rich
HgenePEAK1chr15:77471132chr15:77317625ENST00000312493-25500_50310451747.0Compositional biasNote=Poly-Ser
HgenePEAK1chr15:77471132chr15:77317625ENST00000312493-25776_87310451747.0Compositional biasNote=Pro-rich
HgenePEAK1chr15:77471132chr15:77317625ENST00000312493-25964_96710451747.0Compositional biasNote=Poly-Pro
HgenePEAK1chr15:77471132chr15:77317625ENST00000560626-47117_12010451747.0Compositional biasNote=Poly-Asn
HgenePEAK1chr15:77471132chr15:77317625ENST00000560626-47324_40610451747.0Compositional biasNote=Ser-rich
HgenePEAK1chr15:77471132chr15:77317625ENST00000560626-47500_50310451747.0Compositional biasNote=Poly-Ser
HgenePEAK1chr15:77471132chr15:77317625ENST00000560626-47776_87310451747.0Compositional biasNote=Pro-rich
HgenePEAK1chr15:77471132chr15:77317625ENST00000560626-47964_96710451747.0Compositional biasNote=Poly-Pro
TgenePSTPIP1chr15:77471132chr15:77317625ENST00000558012215166_21270417.0Coiled coilOntology_term=ECO:0000255
TgenePSTPIP1chr15:77471132chr15:77317625ENST00000559295214166_21270398.0Coiled coilOntology_term=ECO:0000255
TgenePSTPIP1chr15:77471132chr15:77317625ENST00000558012215359_41670417.0DomainSH3
TgenePSTPIP1chr15:77471132chr15:77317625ENST00000559295214359_41670398.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePEAK1chr15:77471132chr15:77317625ENST00000312493-251313_167510451747.0DomainProtein kinase
HgenePEAK1chr15:77471132chr15:77317625ENST00000560626-471313_167510451747.0DomainProtein kinase
HgenePEAK1chr15:77471132chr15:77317625ENST00000312493-251285_131110451747.0RegionRequired for homodimerization
HgenePEAK1chr15:77471132chr15:77317625ENST00000312493-251670_174310451747.0RegionRequired for homodimerization
HgenePEAK1chr15:77471132chr15:77317625ENST00000560626-471285_131110451747.0RegionRequired for homodimerization
HgenePEAK1chr15:77471132chr15:77317625ENST00000560626-471670_174310451747.0RegionRequired for homodimerization
TgenePSTPIP1chr15:77471132chr15:77317625ENST000005580122155_26470417.0DomainF-BAR
TgenePSTPIP1chr15:77471132chr15:77317625ENST000005592952145_26470398.0DomainF-BAR


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Fusion Gene Sequence for PEAK1-PSTPIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64203_64203_1_PEAK1-PSTPIP1_PEAK1_chr15_77471132_ENST00000312493_PSTPIP1_chr15_77317625_ENST00000267939_length(transcript)=4552nt_BP=3416nt
TGCAGTAAACATTGCTATCTTCAGAAATTAAGGAATGAGAGGCAAGGAAGAAAGGACATTCATCTTGGAAAGACCCAAAGCACCTTGAAA
TTTGGAAGGAATGTTTTGCTAGCTGCTAAAACCACCTTTGTCACCAGAATGAATGAAGTGCTTCAGATTTAAATAATTGATCATTCTTAG
AAGAGCTGCTGTAACACATAGGGGAAGTGAAAACTAACAGATGAAAGTTTTGTCATGCACTGAAAGAAAAGCATTGTCTGTGAAGTTCTA
TTTTTAAAAATGTCTGCTTGTAACACCTTTACTGAACATGTTTGGAAACCTGGTGAATGCAAGAATTGCTTTAAACCTAAAAGTTTGCAC
CAGCTTCCCCCAGACCCTGAGAAGGCACCCATCACCCATGGCAATGTGAAAACTAATGCCAATCACAGTAACAACCACCGCATCAGGAAC
ACGGGCAATTTCCGGCCTCCTGTGGCTAAAAAACCCACTATAGCTGTGAAGCCCACTATGATAGTGGCAGATGGGCAAAGTATATGTGGT
GAGCTTAGCATCCAAGAACACTGTGAGAACAAACCTGTCATCATAGGGTGGAACCGAAACAGAGCTGCCTTGAGTCAGAAACCACTTAAC
AATAATAATGAAGATGATGAAGGAATTAGCCATGTTCCTAAGCCTTATGGCAATAATGATAGTGCAAAGAAGATGTCAGATAACAATAAT
GGACTAACTGAAGTGTTAAAGGAGATAGCAGGCTTGGATACTGCCCCTCAGATAAGAGGAAATGAAACAAACTCCAGAGAAACATTCTTG
GGAAGAATAAATGATTGCTATAAACGATCATTGGAAAGAAAGCTTCCACCAAGTTGCATGATAGGTGGGATAAAGGAAACTCAGGGCAAG
CATGTTATTCTGAGTGGGAGCACAGAAGTGATTAGTAATGAAGGGGGCCGGTTCTGTTACCCAGAGTTTTCCAGTGGCGAGGAGAGTGAA
GAGGATGTACTTTTCAGTAACATGGAGGAGGAGCACGAGAGTTGGGATGAGAGTGATGAAGAGCTGTTGGCCATGGAGATTCGCATGAGA
GGGCAACCTCGCTTTGCCAACTTCAGAGCAAACACATTGTCTCCTGTTCGATTCTTTGTGGACAAAAAATGGAATACCATCCCCCTGCGA
AACAAGTCTCTGCAGAGAATCTGTGCTGTGGACTATGATGACAGCTATGATGAAATCCTGAATGGTTATGAGGAAAATTCTGTGGTCTCT
TATGGACAAGGAAGCATTCAGAGCATGGTGTCATCTGACTCCACATCACCAGATTCTTCTTTAACAGAAGAATCACGTTCTGAGACAGCC
AGTAGTTTATCCCAGAAGATTTGTAATGGGGGATTATCTCCTGGTAACCCAGGAGATTCTAAGGACATGAAGGAAATTGAGCCCAATTAT
GAAAGTCCCTCTAGTAATAATCAGGATAAAGATTCATCACAGGCTTCCAAAAGCTCAATAAAAGTTCCAGAGACCCACAAAGCAGTCCTT
GCTCTCCGATTAGAAGAGAAAGATGGCAAGATTGCTGTACAAACTGAGAAGGAAGAAAGTAAAGCCTCTACAGATGTTGCTGGGCAAGCA
GTAACCATAAACCTTGTCCCCACAGAAGAGCAAGCAAAACCTTACCGAGTTGTGAACCTGGAACAGCCATTGTGCAAGCCATATACTGTC
GTGGATGTGTCAGCAGCCATGGCCAGTGAGCACCTCGAGGGCCCTGTTAACAGCCCCAAGACAAAAAGCTCATCCTCTACTCCAAACTCT
CCAGTTACATCATCTTCATTGACACCAGGACAAATAAGTGCCCATTTCCAAAAATCCAGTGCAATTCGATACCAAGAAGTATGGACTTCT
AGCACCAGTCCACGACAAAAGATACCTAAAGTAGAACTAATTACTAGTGGAACTGGACCAAATGTTCCTCCAAGGAAAAACTGTCACAAA
TCAGCACCTACATCACCCACAGCTACAAACATTTCCTCCAAAACCATCCCTGTTAAGTCACCTAATTTGTCTGAAATTAAATTTAATAGT
TATAACAATGCTGGTATGCCACCTTTTCCAATTATCATTCATGACGAGCCAACTTATGCTCGGAGTTCCAAAAATGCTATCAAAGTTCCC
ATTGTTATCAATCCAAATGCATATGACAATCTAGCTATCTACAAAAGTTTTCTGGGAACAAGTGGAGAACTCTCAGTGAAGGAAAAAACC
ACAAGTGTAATAAGCCATACTTATGAAGAAATAGAAACAGAAAGCAAAGTGCCTGATAACACCACTAGCAAAACCACTGACTGTCTTCAA
ACTAAAGGGTTTTCAAACAGCACAGAGCATAAAAGGGGCTCAGTGGCTCAGAAGGTTCAAGAGTTTAACAACTGTCTCAACAGAGGTCAG
TCTTCACCACAGAGAAGCTATAGTTCCAGCCACAGCTCCCCAGCAAAGATCCAGAGAGCCACTCAAGAGCCTGTGGCCAAAATAGAAGGC
ACTCAGGAGTCTCAGATGGTGGGCAGCAGCAGCACCAGAGAGAAAGCAAGCACAGTGCTTTCTCAGATTGTGGCTTCAATCCAACCCCCA
CAGTCTCCTCCAGAAACACCTCAATCTGGCCCTAAAGCTTGCAGTGTGGAAGAGCTTTATGCCATTCCTCCAGATGCTGATGTTGCTAAG
AGCACACCTAAGAGTACGCCAGTCCGGCCCAAATCTCTCTTTACATCTCAGCCTAGTGGTGAGGCTGAAGCACCTCAGACCACAGACAGT
CCTACCACCAAAGTACAGAAAGACCCATCCATAAAGCCAGTCACCCCCTCTCCCTCCAAATTAGTGACTAGCCCCCAAAGTGAGCCACCA
GCTCCCTTTCCCCCGCCACGCTCTACTTCTTCTCCTTACCATGCAGGTAACCTTTTGCAGAGGCATTTCACCAACTGGACCAAGCCAACC
AGCCCTACCAGGTCAACAGAAGCTGAATCAGTTTTGCACTCTGAAGGCAGCAGGCGGGCAGCTGATGCAAAACCTAAGCGCTGGATATCA
TTTAAAAGCTTCTTCCGCCGTCGGAAAACAGATGAGGAGGATGACAAAGAGAAAGAGCGAGAGAAAGGGAAACTGGTGGGCCTGGATGGC
ACAGTCATTCACATGCTGCCTCCTCCTCCAGTTCAGCGCCATCACTGGTTCACAGAGGCGAAAGGAGAGTCCAGTGAGAAACCAGCCATT
GTCTTCATGTACAGGTGCGACCCTGCTCAAGGCCAGCTCAGTGTGGATCAGAGCAAGGCTAGGACAGACCAGGCAGCAGTCATGGAGAAG
GGTAGAGCAGAGAATGCATTACTACAGGACTCAGAGAAGAAGAGGAGTCATTCTTCTCCATCACAGATTCCTAAAAAGATTCTCAGCTCC
CTGAGGGCCTCCTTTGACTCCTTGAAGCAGCAAATGGAGAATGTGGGCAGCTCACACATCCAGCTGGCCCTGACCCTGCGTGAGGAGCTG
CGGAGTCTCGAGGAGTTTCGTGAGAGGCAGAAGGAGCAGAGGAAGAAGTATGAGGCCGTCATGGACCGGGTCCAGAAGAGCAAGCTGTCG
CTCTACAAGAAGGCCATGGAGTCCAAGAAGACATACGAGCAGAAGTGCCGGGACGCGGACGACGCGGAGCAGGCCTTCGAGCGCATTAGC
GCCAACGGCCACCAGAAGCAGGTGGAGAAGAGTCAGAACAAAGCCAGGCAGTGCAAGGACTCGGCCACCGAGGCAGAGCGGGTATACAGG
CAGAGCATTGCGCAGCTGGAGAAGGTCCGGGCTGAGTGGGAGCAGGAGCACCGGACCACCTGTGAGGCCTTTCAGCTGCAAGAGTTTGAC
CGGCTGACCATTCTCCGCAACGCCCTGTGGGTGCACAGCAACCAGCTCTCCATGCAGTGTGTCAAGGATGATGAGCTCTACGAGGAAGTG
CGGCTGACGCTGGAAGGCTGCAGCATAGACGCCGACATCGACAGTTTCATCCAGGCCAAGAGCACGGGCACAGAGCCCCCCGGTGAGGTC
CGGCTTGCGGACAGCGCAGCCTCTAGGTTCTCTGGACTGCTGCACGGAAGTCCCAAGACCACTTCGTTGGCAGCTTCTGCTGCGTCCACA
GAGACCCTGACCCCCACCCCCGAGCGGAATGAGGGTGTCTACACAGCCATCGCAGTGCAGGAGATACAGGGAAACCCGGCCTCACCAGCC
CAGGAGTACCGGGCGCTCTACGATTATACAGCGCAGAACCCAGATGAGCTGGACCTGTCCGCGGGAGACATCCTGGAGGTGATCCTGGAA
GGGGAGGATGGCTGGTGGACTGTGGAGAGGAACGGGCAGCGTGGCTTCGTCCCTGGTTCCTACCTGGAGAAGCTTTGAGGAAGGGCCAGG
AGCCCCTTCGGACCTGCCCTGCCAGTGGAGCCAGCAGTGCCCCCAGCACTGTCCCCACCTTGCTAGGGCCCAGAACCAAGCGTCCCCCAG

>64203_64203_1_PEAK1-PSTPIP1_PEAK1_chr15_77471132_ENST00000312493_PSTPIP1_chr15_77317625_ENST00000267939_length(amino acids)=1372AA_BP=1035
MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDPEKAPITHGNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGELS
IQEHCENKPVIIGWNRNRAALSQKPLNNNNEDDEGISHVPKPYGNNDSAKKMSDNNNGLTEVLKEIAGLDTAPQIRGNETNSRETFLGRI
NDCYKRSLERKLPPSCMIGGIKETQGKHVILSGSTEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQP
RFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSVVSYGQGSIQSMVSSDSTSPDSSLTEESRSETASSL
SQKICNGGLSPGNPGDSKDMKEIEPNYESPSSNNQDKDSSQASKSSIKVPETHKAVLALRLEEKDGKIAVQTEKEESKASTDVAGQAVTI
NLVPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAMASEHLEGPVNSPKTKSSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTS
PRQKIPKVELITSGTGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPTYARSSKNAIKVPIVI
NPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVPDNTTSKTTDCLQTKGFSNSTEHKRGSVAQKVQEFNNCLNRGQSSP
QRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVGSSSTREKASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTP
KSTPVRPKSLFTSQPSGEAEAPQTTDSPTTKVQKDPSIKPVTPSPSKLVTSPQSEPPAPFPPPRSTSSPYHAGNLLQRHFTNWTKPTSPT
RSTEAESVLHSEGSRRAADAKPKRWISFKSFFRRRKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFM
YRCDPAQGQLSVDQSKARTDQAAVMEKGRAENALLQDSEKKRSHSSPSQIPKKILSSLRASFDSLKQQMENVGSSHIQLALTLREELRSL
EEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKDSATEAERVYRQSI
AQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPGEVRLA
DSAASRFSGLLHGSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGED

--------------------------------------------------------------
>64203_64203_2_PEAK1-PSTPIP1_PEAK1_chr15_77471132_ENST00000312493_PSTPIP1_chr15_77317625_ENST00000379595_length(transcript)=4601nt_BP=3416nt
TGCAGTAAACATTGCTATCTTCAGAAATTAAGGAATGAGAGGCAAGGAAGAAAGGACATTCATCTTGGAAAGACCCAAAGCACCTTGAAA
TTTGGAAGGAATGTTTTGCTAGCTGCTAAAACCACCTTTGTCACCAGAATGAATGAAGTGCTTCAGATTTAAATAATTGATCATTCTTAG
AAGAGCTGCTGTAACACATAGGGGAAGTGAAAACTAACAGATGAAAGTTTTGTCATGCACTGAAAGAAAAGCATTGTCTGTGAAGTTCTA
TTTTTAAAAATGTCTGCTTGTAACACCTTTACTGAACATGTTTGGAAACCTGGTGAATGCAAGAATTGCTTTAAACCTAAAAGTTTGCAC
CAGCTTCCCCCAGACCCTGAGAAGGCACCCATCACCCATGGCAATGTGAAAACTAATGCCAATCACAGTAACAACCACCGCATCAGGAAC
ACGGGCAATTTCCGGCCTCCTGTGGCTAAAAAACCCACTATAGCTGTGAAGCCCACTATGATAGTGGCAGATGGGCAAAGTATATGTGGT
GAGCTTAGCATCCAAGAACACTGTGAGAACAAACCTGTCATCATAGGGTGGAACCGAAACAGAGCTGCCTTGAGTCAGAAACCACTTAAC
AATAATAATGAAGATGATGAAGGAATTAGCCATGTTCCTAAGCCTTATGGCAATAATGATAGTGCAAAGAAGATGTCAGATAACAATAAT
GGACTAACTGAAGTGTTAAAGGAGATAGCAGGCTTGGATACTGCCCCTCAGATAAGAGGAAATGAAACAAACTCCAGAGAAACATTCTTG
GGAAGAATAAATGATTGCTATAAACGATCATTGGAAAGAAAGCTTCCACCAAGTTGCATGATAGGTGGGATAAAGGAAACTCAGGGCAAG
CATGTTATTCTGAGTGGGAGCACAGAAGTGATTAGTAATGAAGGGGGCCGGTTCTGTTACCCAGAGTTTTCCAGTGGCGAGGAGAGTGAA
GAGGATGTACTTTTCAGTAACATGGAGGAGGAGCACGAGAGTTGGGATGAGAGTGATGAAGAGCTGTTGGCCATGGAGATTCGCATGAGA
GGGCAACCTCGCTTTGCCAACTTCAGAGCAAACACATTGTCTCCTGTTCGATTCTTTGTGGACAAAAAATGGAATACCATCCCCCTGCGA
AACAAGTCTCTGCAGAGAATCTGTGCTGTGGACTATGATGACAGCTATGATGAAATCCTGAATGGTTATGAGGAAAATTCTGTGGTCTCT
TATGGACAAGGAAGCATTCAGAGCATGGTGTCATCTGACTCCACATCACCAGATTCTTCTTTAACAGAAGAATCACGTTCTGAGACAGCC
AGTAGTTTATCCCAGAAGATTTGTAATGGGGGATTATCTCCTGGTAACCCAGGAGATTCTAAGGACATGAAGGAAATTGAGCCCAATTAT
GAAAGTCCCTCTAGTAATAATCAGGATAAAGATTCATCACAGGCTTCCAAAAGCTCAATAAAAGTTCCAGAGACCCACAAAGCAGTCCTT
GCTCTCCGATTAGAAGAGAAAGATGGCAAGATTGCTGTACAAACTGAGAAGGAAGAAAGTAAAGCCTCTACAGATGTTGCTGGGCAAGCA
GTAACCATAAACCTTGTCCCCACAGAAGAGCAAGCAAAACCTTACCGAGTTGTGAACCTGGAACAGCCATTGTGCAAGCCATATACTGTC
GTGGATGTGTCAGCAGCCATGGCCAGTGAGCACCTCGAGGGCCCTGTTAACAGCCCCAAGACAAAAAGCTCATCCTCTACTCCAAACTCT
CCAGTTACATCATCTTCATTGACACCAGGACAAATAAGTGCCCATTTCCAAAAATCCAGTGCAATTCGATACCAAGAAGTATGGACTTCT
AGCACCAGTCCACGACAAAAGATACCTAAAGTAGAACTAATTACTAGTGGAACTGGACCAAATGTTCCTCCAAGGAAAAACTGTCACAAA
TCAGCACCTACATCACCCACAGCTACAAACATTTCCTCCAAAACCATCCCTGTTAAGTCACCTAATTTGTCTGAAATTAAATTTAATAGT
TATAACAATGCTGGTATGCCACCTTTTCCAATTATCATTCATGACGAGCCAACTTATGCTCGGAGTTCCAAAAATGCTATCAAAGTTCCC
ATTGTTATCAATCCAAATGCATATGACAATCTAGCTATCTACAAAAGTTTTCTGGGAACAAGTGGAGAACTCTCAGTGAAGGAAAAAACC
ACAAGTGTAATAAGCCATACTTATGAAGAAATAGAAACAGAAAGCAAAGTGCCTGATAACACCACTAGCAAAACCACTGACTGTCTTCAA
ACTAAAGGGTTTTCAAACAGCACAGAGCATAAAAGGGGCTCAGTGGCTCAGAAGGTTCAAGAGTTTAACAACTGTCTCAACAGAGGTCAG
TCTTCACCACAGAGAAGCTATAGTTCCAGCCACAGCTCCCCAGCAAAGATCCAGAGAGCCACTCAAGAGCCTGTGGCCAAAATAGAAGGC
ACTCAGGAGTCTCAGATGGTGGGCAGCAGCAGCACCAGAGAGAAAGCAAGCACAGTGCTTTCTCAGATTGTGGCTTCAATCCAACCCCCA
CAGTCTCCTCCAGAAACACCTCAATCTGGCCCTAAAGCTTGCAGTGTGGAAGAGCTTTATGCCATTCCTCCAGATGCTGATGTTGCTAAG
AGCACACCTAAGAGTACGCCAGTCCGGCCCAAATCTCTCTTTACATCTCAGCCTAGTGGTGAGGCTGAAGCACCTCAGACCACAGACAGT
CCTACCACCAAAGTACAGAAAGACCCATCCATAAAGCCAGTCACCCCCTCTCCCTCCAAATTAGTGACTAGCCCCCAAAGTGAGCCACCA
GCTCCCTTTCCCCCGCCACGCTCTACTTCTTCTCCTTACCATGCAGGTAACCTTTTGCAGAGGCATTTCACCAACTGGACCAAGCCAACC
AGCCCTACCAGGTCAACAGAAGCTGAATCAGTTTTGCACTCTGAAGGCAGCAGGCGGGCAGCTGATGCAAAACCTAAGCGCTGGATATCA
TTTAAAAGCTTCTTCCGCCGTCGGAAAACAGATGAGGAGGATGACAAAGAGAAAGAGCGAGAGAAAGGGAAACTGGTGGGCCTGGATGGC
ACAGTCATTCACATGCTGCCTCCTCCTCCAGTTCAGCGCCATCACTGGTTCACAGAGGCGAAAGGAGAGTCCAGTGAGAAACCAGCCATT
GTCTTCATGTACAGGTGCGACCCTGCTCAAGGCCAGCTCAGTGTGGATCAGAGCAAGGCTAGGACAGACCAGGCAGCAGTCATGGAGAAG
GGTAGAGCAGAGAATGCATTACTACAGGACTCAGAGAAGAAGAGGAGTCATTCTTCTCCATCACAGATTCCTAAAAAGATTCTCAGCTCC
CTGAGGGCCTCCTTTGACTCCTTGAAGCAGCAAATGGAGAATGTGGGCAGCTCACACATCCAGCTGGCCCTGACCCTGCGTGAGGAGCTG
CGGAGTCTCGAGGAGTTTCGTGAGAGGCAGAAGGAGCAGAGGAAGAAGTATGAGGCCGTCATGGACCGGGTCCAGAAGAGCAAGCTGTCG
CTCTACAAGAAGGCCATGGAGTCCAAGAAGACATACGAGCAGAAGTGCCGGGACGCGGACGACGCGGAGCAGGCCTTCGAGCGCATTAGC
GCCAACGGCCACCAGAAGCAGGTGGAGAAGAGTCAGAACAAAGCCAGGCAGTGCAAGGACTCGGCCACCGAGGCAGAGCGGGTATACAGG
CAGAGCATTGCGCAGCTGGAGAAGGTCCGGGCTGAGTGGGAGCAGGAGCACCGGACCACCTGTGAGGCCTTTCAGCTGCAAGAGTTTGAC
CGGCTGACCATTCTCCGCAACGCCCTGTGGGTGCACAGCAACCAGCTCTCCATGCAGTGTGTCAAGGATGATGAGCTCTACGAGGAAGTG
CGGCTGACGCTGGAAGGCTGCAGCATAGACGCCGACATCGACAGTTTCATCCAGGCCAAGAGCACGGGCACAGAGCCCCCCGCTCCGGTG
CCCTACCAGAACTATTACGATCGGGAGGTCACCCCGCTGACCAGCAGCCCTGGCATACAGCCGTCCTGCGGCATGATAAAGAGGTTCTCT
GGACTGCTGCACGGAAGTCCCAAGACCACTTCGTTGGCAGCTTCTGCTGAGACCCTGACCCCCACCCCCGAGCGGAATGAGGGTGTCTAC
ACAGCCATCGCAGTGCAGGAGATACAGGGAAACCCGGCCTCACCAGCCCAGGAGTACCGGGCGCTCTACGATTATACAGCGCAGAACCCA
GATGAGCTGGACCTGTCCGCGGGAGACATCCTGGAGGTGATCCTGGAAGGGGAGGATGGCTGGTGGACTGTGGAGAGGAACGGGCAGCGT
GGCTTCGTCCCTGGTTCCTACCTGGAGAAGCTTTGAGGAAGGGCCAGGAGCCCCTTCGGACCTGCCCTGCCAGTGGAGCCAGCAGTGCCC
CCAGCACTGTCCCCACCTTGCTAGGGCCCAGAACCAAGCGTCCCCCAGCCCCGAGAGGGAGCCTGTCGTCTCCCAGGGAATAAAGGAGTG

>64203_64203_2_PEAK1-PSTPIP1_PEAK1_chr15_77471132_ENST00000312493_PSTPIP1_chr15_77317625_ENST00000379595_length(amino acids)=1388AA_BP=1035
MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDPEKAPITHGNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGELS
IQEHCENKPVIIGWNRNRAALSQKPLNNNNEDDEGISHVPKPYGNNDSAKKMSDNNNGLTEVLKEIAGLDTAPQIRGNETNSRETFLGRI
NDCYKRSLERKLPPSCMIGGIKETQGKHVILSGSTEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQP
RFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSVVSYGQGSIQSMVSSDSTSPDSSLTEESRSETASSL
SQKICNGGLSPGNPGDSKDMKEIEPNYESPSSNNQDKDSSQASKSSIKVPETHKAVLALRLEEKDGKIAVQTEKEESKASTDVAGQAVTI
NLVPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAMASEHLEGPVNSPKTKSSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTS
PRQKIPKVELITSGTGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPTYARSSKNAIKVPIVI
NPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVPDNTTSKTTDCLQTKGFSNSTEHKRGSVAQKVQEFNNCLNRGQSSP
QRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVGSSSTREKASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTP
KSTPVRPKSLFTSQPSGEAEAPQTTDSPTTKVQKDPSIKPVTPSPSKLVTSPQSEPPAPFPPPRSTSSPYHAGNLLQRHFTNWTKPTSPT
RSTEAESVLHSEGSRRAADAKPKRWISFKSFFRRRKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFM
YRCDPAQGQLSVDQSKARTDQAAVMEKGRAENALLQDSEKKRSHSSPSQIPKKILSSLRASFDSLKQQMENVGSSHIQLALTLREELRSL
EEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKDSATEAERVYRQSI
AQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQ
NYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPKTTSLAASAETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDEL

--------------------------------------------------------------
>64203_64203_3_PEAK1-PSTPIP1_PEAK1_chr15_77471132_ENST00000312493_PSTPIP1_chr15_77317625_ENST00000558012_length(transcript)=4611nt_BP=3416nt
TGCAGTAAACATTGCTATCTTCAGAAATTAAGGAATGAGAGGCAAGGAAGAAAGGACATTCATCTTGGAAAGACCCAAAGCACCTTGAAA
TTTGGAAGGAATGTTTTGCTAGCTGCTAAAACCACCTTTGTCACCAGAATGAATGAAGTGCTTCAGATTTAAATAATTGATCATTCTTAG
AAGAGCTGCTGTAACACATAGGGGAAGTGAAAACTAACAGATGAAAGTTTTGTCATGCACTGAAAGAAAAGCATTGTCTGTGAAGTTCTA
TTTTTAAAAATGTCTGCTTGTAACACCTTTACTGAACATGTTTGGAAACCTGGTGAATGCAAGAATTGCTTTAAACCTAAAAGTTTGCAC
CAGCTTCCCCCAGACCCTGAGAAGGCACCCATCACCCATGGCAATGTGAAAACTAATGCCAATCACAGTAACAACCACCGCATCAGGAAC
ACGGGCAATTTCCGGCCTCCTGTGGCTAAAAAACCCACTATAGCTGTGAAGCCCACTATGATAGTGGCAGATGGGCAAAGTATATGTGGT
GAGCTTAGCATCCAAGAACACTGTGAGAACAAACCTGTCATCATAGGGTGGAACCGAAACAGAGCTGCCTTGAGTCAGAAACCACTTAAC
AATAATAATGAAGATGATGAAGGAATTAGCCATGTTCCTAAGCCTTATGGCAATAATGATAGTGCAAAGAAGATGTCAGATAACAATAAT
GGACTAACTGAAGTGTTAAAGGAGATAGCAGGCTTGGATACTGCCCCTCAGATAAGAGGAAATGAAACAAACTCCAGAGAAACATTCTTG
GGAAGAATAAATGATTGCTATAAACGATCATTGGAAAGAAAGCTTCCACCAAGTTGCATGATAGGTGGGATAAAGGAAACTCAGGGCAAG
CATGTTATTCTGAGTGGGAGCACAGAAGTGATTAGTAATGAAGGGGGCCGGTTCTGTTACCCAGAGTTTTCCAGTGGCGAGGAGAGTGAA
GAGGATGTACTTTTCAGTAACATGGAGGAGGAGCACGAGAGTTGGGATGAGAGTGATGAAGAGCTGTTGGCCATGGAGATTCGCATGAGA
GGGCAACCTCGCTTTGCCAACTTCAGAGCAAACACATTGTCTCCTGTTCGATTCTTTGTGGACAAAAAATGGAATACCATCCCCCTGCGA
AACAAGTCTCTGCAGAGAATCTGTGCTGTGGACTATGATGACAGCTATGATGAAATCCTGAATGGTTATGAGGAAAATTCTGTGGTCTCT
TATGGACAAGGAAGCATTCAGAGCATGGTGTCATCTGACTCCACATCACCAGATTCTTCTTTAACAGAAGAATCACGTTCTGAGACAGCC
AGTAGTTTATCCCAGAAGATTTGTAATGGGGGATTATCTCCTGGTAACCCAGGAGATTCTAAGGACATGAAGGAAATTGAGCCCAATTAT
GAAAGTCCCTCTAGTAATAATCAGGATAAAGATTCATCACAGGCTTCCAAAAGCTCAATAAAAGTTCCAGAGACCCACAAAGCAGTCCTT
GCTCTCCGATTAGAAGAGAAAGATGGCAAGATTGCTGTACAAACTGAGAAGGAAGAAAGTAAAGCCTCTACAGATGTTGCTGGGCAAGCA
GTAACCATAAACCTTGTCCCCACAGAAGAGCAAGCAAAACCTTACCGAGTTGTGAACCTGGAACAGCCATTGTGCAAGCCATATACTGTC
GTGGATGTGTCAGCAGCCATGGCCAGTGAGCACCTCGAGGGCCCTGTTAACAGCCCCAAGACAAAAAGCTCATCCTCTACTCCAAACTCT
CCAGTTACATCATCTTCATTGACACCAGGACAAATAAGTGCCCATTTCCAAAAATCCAGTGCAATTCGATACCAAGAAGTATGGACTTCT
AGCACCAGTCCACGACAAAAGATACCTAAAGTAGAACTAATTACTAGTGGAACTGGACCAAATGTTCCTCCAAGGAAAAACTGTCACAAA
TCAGCACCTACATCACCCACAGCTACAAACATTTCCTCCAAAACCATCCCTGTTAAGTCACCTAATTTGTCTGAAATTAAATTTAATAGT
TATAACAATGCTGGTATGCCACCTTTTCCAATTATCATTCATGACGAGCCAACTTATGCTCGGAGTTCCAAAAATGCTATCAAAGTTCCC
ATTGTTATCAATCCAAATGCATATGACAATCTAGCTATCTACAAAAGTTTTCTGGGAACAAGTGGAGAACTCTCAGTGAAGGAAAAAACC
ACAAGTGTAATAAGCCATACTTATGAAGAAATAGAAACAGAAAGCAAAGTGCCTGATAACACCACTAGCAAAACCACTGACTGTCTTCAA
ACTAAAGGGTTTTCAAACAGCACAGAGCATAAAAGGGGCTCAGTGGCTCAGAAGGTTCAAGAGTTTAACAACTGTCTCAACAGAGGTCAG
TCTTCACCACAGAGAAGCTATAGTTCCAGCCACAGCTCCCCAGCAAAGATCCAGAGAGCCACTCAAGAGCCTGTGGCCAAAATAGAAGGC
ACTCAGGAGTCTCAGATGGTGGGCAGCAGCAGCACCAGAGAGAAAGCAAGCACAGTGCTTTCTCAGATTGTGGCTTCAATCCAACCCCCA
CAGTCTCCTCCAGAAACACCTCAATCTGGCCCTAAAGCTTGCAGTGTGGAAGAGCTTTATGCCATTCCTCCAGATGCTGATGTTGCTAAG
AGCACACCTAAGAGTACGCCAGTCCGGCCCAAATCTCTCTTTACATCTCAGCCTAGTGGTGAGGCTGAAGCACCTCAGACCACAGACAGT
CCTACCACCAAAGTACAGAAAGACCCATCCATAAAGCCAGTCACCCCCTCTCCCTCCAAATTAGTGACTAGCCCCCAAAGTGAGCCACCA
GCTCCCTTTCCCCCGCCACGCTCTACTTCTTCTCCTTACCATGCAGGTAACCTTTTGCAGAGGCATTTCACCAACTGGACCAAGCCAACC
AGCCCTACCAGGTCAACAGAAGCTGAATCAGTTTTGCACTCTGAAGGCAGCAGGCGGGCAGCTGATGCAAAACCTAAGCGCTGGATATCA
TTTAAAAGCTTCTTCCGCCGTCGGAAAACAGATGAGGAGGATGACAAAGAGAAAGAGCGAGAGAAAGGGAAACTGGTGGGCCTGGATGGC
ACAGTCATTCACATGCTGCCTCCTCCTCCAGTTCAGCGCCATCACTGGTTCACAGAGGCGAAAGGAGAGTCCAGTGAGAAACCAGCCATT
GTCTTCATGTACAGGTGCGACCCTGCTCAAGGCCAGCTCAGTGTGGATCAGAGCAAGGCTAGGACAGACCAGGCAGCAGTCATGGAGAAG
GGTAGAGCAGAGAATGCATTACTACAGGACTCAGAGAAGAAGAGGAGTCATTCTTCTCCATCACAGATTCCTAAAAAGATTCTCAGCTCC
CTGAGGGCCTCCTTTGACTCCTTGAAGCAGCAAATGGAGAATGTGGGCAGCTCACACATCCAGCTGGCCCTGACCCTGCGTGAGGAGCTG
CGGAGTCTCGAGGAGTTTCGTGAGAGGCAGAAGGAGCAGAGGAAGAAGTATGAGGCCGTCATGGACCGGGTCCAGAAGAGCAAGCTGTCG
CTCTACAAGAAGGCCATGGAGTCCAAGAAGACATACGAGCAGAAGTGCCGGGACGCGGACGACGCGGAGCAGGCCTTCGAGCGCATTAGC
GCCAACGGCCACCAGAAGCAGGTGGAGAAGAGTCAGAACAAAGCCAGGCAGTGCAAGGACTCGGCCACCGAGGCAGAGCGGGTATACAGG
CAGAGCATTGCGCAGCTGGAGAAGGTCCGGGCTGAGTGGGAGCAGGAGCACCGGACCACCTGTGAGGCCTTTCAGCTGCAAGAGTTTGAC
CGGCTGACCATTCTCCGCAACGCCCTGTGGGTGCACAGCAACCAGCTCTCCATGCAGTGTGTCAAGGATGATGAGCTCTACGAGGAAGTG
CGGCTGACGCTGGAAGGCTGCAGCATAGACGCCGACATCGACAGTTTCATCCAGGCCAAGAGCACGGGCACAGAGCCCCCCGCTCCGGTG
CCCTACCAGAACTATTACGATCGGGAGGTCACCCCGCTGACCAGCAGCCCTGGCATACAGCCGTCCTGCGGCATGATAAAGAGGTTCTCT
GGACTGCTGCACGGAAGTCCCAAGACCACTTCGTTGGCAGCTTCTGCTGCGTCCACAGAGACCCTGACCCCCACCCCCGAGCGGAATGAG
GGTGTCTACACAGCCATCGCAGTGCAGGAGATACAGGGAAACCCGGCCTCACCAGCCCAGGAGTACCGGGCGCTCTACGATTATACAGCG
CAGAACCCAGATGAGCTGGACCTGTCCGCGGGAGACATCCTGGAGGTGATCCTGGAAGGGGAGGATGGCTGGTGGACTGTGGAGAGGAAC
GGGCAGCGTGGCTTCGTCCCTGGTTCCTACCTGGAGAAGCTTTGAGGAAGGGCCAGGAGCCCCTTCGGACCTGCCCTGCCAGTGGAGCCA
GCAGTGCCCCCAGCACTGTCCCCACCTTGCTAGGGCCCAGAACCAAGCGTCCCCCAGCCCCGAGAGGGAGCCTGTCGTCTCCCAGGGAAT

>64203_64203_3_PEAK1-PSTPIP1_PEAK1_chr15_77471132_ENST00000312493_PSTPIP1_chr15_77317625_ENST00000558012_length(amino acids)=1391AA_BP=1035
MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDPEKAPITHGNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGELS
IQEHCENKPVIIGWNRNRAALSQKPLNNNNEDDEGISHVPKPYGNNDSAKKMSDNNNGLTEVLKEIAGLDTAPQIRGNETNSRETFLGRI
NDCYKRSLERKLPPSCMIGGIKETQGKHVILSGSTEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQP
RFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSVVSYGQGSIQSMVSSDSTSPDSSLTEESRSETASSL
SQKICNGGLSPGNPGDSKDMKEIEPNYESPSSNNQDKDSSQASKSSIKVPETHKAVLALRLEEKDGKIAVQTEKEESKASTDVAGQAVTI
NLVPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAMASEHLEGPVNSPKTKSSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTS
PRQKIPKVELITSGTGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPTYARSSKNAIKVPIVI
NPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVPDNTTSKTTDCLQTKGFSNSTEHKRGSVAQKVQEFNNCLNRGQSSP
QRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVGSSSTREKASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTP
KSTPVRPKSLFTSQPSGEAEAPQTTDSPTTKVQKDPSIKPVTPSPSKLVTSPQSEPPAPFPPPRSTSSPYHAGNLLQRHFTNWTKPTSPT
RSTEAESVLHSEGSRRAADAKPKRWISFKSFFRRRKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFM
YRCDPAQGQLSVDQSKARTDQAAVMEKGRAENALLQDSEKKRSHSSPSQIPKKILSSLRASFDSLKQQMENVGSSHIQLALTLREELRSL
EEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKDSATEAERVYRQSI
AQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQ
NYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNP

--------------------------------------------------------------
>64203_64203_4_PEAK1-PSTPIP1_PEAK1_chr15_77471132_ENST00000312493_PSTPIP1_chr15_77317625_ENST00000559295_length(transcript)=4553nt_BP=3416nt
TGCAGTAAACATTGCTATCTTCAGAAATTAAGGAATGAGAGGCAAGGAAGAAAGGACATTCATCTTGGAAAGACCCAAAGCACCTTGAAA
TTTGGAAGGAATGTTTTGCTAGCTGCTAAAACCACCTTTGTCACCAGAATGAATGAAGTGCTTCAGATTTAAATAATTGATCATTCTTAG
AAGAGCTGCTGTAACACATAGGGGAAGTGAAAACTAACAGATGAAAGTTTTGTCATGCACTGAAAGAAAAGCATTGTCTGTGAAGTTCTA
TTTTTAAAAATGTCTGCTTGTAACACCTTTACTGAACATGTTTGGAAACCTGGTGAATGCAAGAATTGCTTTAAACCTAAAAGTTTGCAC
CAGCTTCCCCCAGACCCTGAGAAGGCACCCATCACCCATGGCAATGTGAAAACTAATGCCAATCACAGTAACAACCACCGCATCAGGAAC
ACGGGCAATTTCCGGCCTCCTGTGGCTAAAAAACCCACTATAGCTGTGAAGCCCACTATGATAGTGGCAGATGGGCAAAGTATATGTGGT
GAGCTTAGCATCCAAGAACACTGTGAGAACAAACCTGTCATCATAGGGTGGAACCGAAACAGAGCTGCCTTGAGTCAGAAACCACTTAAC
AATAATAATGAAGATGATGAAGGAATTAGCCATGTTCCTAAGCCTTATGGCAATAATGATAGTGCAAAGAAGATGTCAGATAACAATAAT
GGACTAACTGAAGTGTTAAAGGAGATAGCAGGCTTGGATACTGCCCCTCAGATAAGAGGAAATGAAACAAACTCCAGAGAAACATTCTTG
GGAAGAATAAATGATTGCTATAAACGATCATTGGAAAGAAAGCTTCCACCAAGTTGCATGATAGGTGGGATAAAGGAAACTCAGGGCAAG
CATGTTATTCTGAGTGGGAGCACAGAAGTGATTAGTAATGAAGGGGGCCGGTTCTGTTACCCAGAGTTTTCCAGTGGCGAGGAGAGTGAA
GAGGATGTACTTTTCAGTAACATGGAGGAGGAGCACGAGAGTTGGGATGAGAGTGATGAAGAGCTGTTGGCCATGGAGATTCGCATGAGA
GGGCAACCTCGCTTTGCCAACTTCAGAGCAAACACATTGTCTCCTGTTCGATTCTTTGTGGACAAAAAATGGAATACCATCCCCCTGCGA
AACAAGTCTCTGCAGAGAATCTGTGCTGTGGACTATGATGACAGCTATGATGAAATCCTGAATGGTTATGAGGAAAATTCTGTGGTCTCT
TATGGACAAGGAAGCATTCAGAGCATGGTGTCATCTGACTCCACATCACCAGATTCTTCTTTAACAGAAGAATCACGTTCTGAGACAGCC
AGTAGTTTATCCCAGAAGATTTGTAATGGGGGATTATCTCCTGGTAACCCAGGAGATTCTAAGGACATGAAGGAAATTGAGCCCAATTAT
GAAAGTCCCTCTAGTAATAATCAGGATAAAGATTCATCACAGGCTTCCAAAAGCTCAATAAAAGTTCCAGAGACCCACAAAGCAGTCCTT
GCTCTCCGATTAGAAGAGAAAGATGGCAAGATTGCTGTACAAACTGAGAAGGAAGAAAGTAAAGCCTCTACAGATGTTGCTGGGCAAGCA
GTAACCATAAACCTTGTCCCCACAGAAGAGCAAGCAAAACCTTACCGAGTTGTGAACCTGGAACAGCCATTGTGCAAGCCATATACTGTC
GTGGATGTGTCAGCAGCCATGGCCAGTGAGCACCTCGAGGGCCCTGTTAACAGCCCCAAGACAAAAAGCTCATCCTCTACTCCAAACTCT
CCAGTTACATCATCTTCATTGACACCAGGACAAATAAGTGCCCATTTCCAAAAATCCAGTGCAATTCGATACCAAGAAGTATGGACTTCT
AGCACCAGTCCACGACAAAAGATACCTAAAGTAGAACTAATTACTAGTGGAACTGGACCAAATGTTCCTCCAAGGAAAAACTGTCACAAA
TCAGCACCTACATCACCCACAGCTACAAACATTTCCTCCAAAACCATCCCTGTTAAGTCACCTAATTTGTCTGAAATTAAATTTAATAGT
TATAACAATGCTGGTATGCCACCTTTTCCAATTATCATTCATGACGAGCCAACTTATGCTCGGAGTTCCAAAAATGCTATCAAAGTTCCC
ATTGTTATCAATCCAAATGCATATGACAATCTAGCTATCTACAAAAGTTTTCTGGGAACAAGTGGAGAACTCTCAGTGAAGGAAAAAACC
ACAAGTGTAATAAGCCATACTTATGAAGAAATAGAAACAGAAAGCAAAGTGCCTGATAACACCACTAGCAAAACCACTGACTGTCTTCAA
ACTAAAGGGTTTTCAAACAGCACAGAGCATAAAAGGGGCTCAGTGGCTCAGAAGGTTCAAGAGTTTAACAACTGTCTCAACAGAGGTCAG
TCTTCACCACAGAGAAGCTATAGTTCCAGCCACAGCTCCCCAGCAAAGATCCAGAGAGCCACTCAAGAGCCTGTGGCCAAAATAGAAGGC
ACTCAGGAGTCTCAGATGGTGGGCAGCAGCAGCACCAGAGAGAAAGCAAGCACAGTGCTTTCTCAGATTGTGGCTTCAATCCAACCCCCA
CAGTCTCCTCCAGAAACACCTCAATCTGGCCCTAAAGCTTGCAGTGTGGAAGAGCTTTATGCCATTCCTCCAGATGCTGATGTTGCTAAG
AGCACACCTAAGAGTACGCCAGTCCGGCCCAAATCTCTCTTTACATCTCAGCCTAGTGGTGAGGCTGAAGCACCTCAGACCACAGACAGT
CCTACCACCAAAGTACAGAAAGACCCATCCATAAAGCCAGTCACCCCCTCTCCCTCCAAATTAGTGACTAGCCCCCAAAGTGAGCCACCA
GCTCCCTTTCCCCCGCCACGCTCTACTTCTTCTCCTTACCATGCAGGTAACCTTTTGCAGAGGCATTTCACCAACTGGACCAAGCCAACC
AGCCCTACCAGGTCAACAGAAGCTGAATCAGTTTTGCACTCTGAAGGCAGCAGGCGGGCAGCTGATGCAAAACCTAAGCGCTGGATATCA
TTTAAAAGCTTCTTCCGCCGTCGGAAAACAGATGAGGAGGATGACAAAGAGAAAGAGCGAGAGAAAGGGAAACTGGTGGGCCTGGATGGC
ACAGTCATTCACATGCTGCCTCCTCCTCCAGTTCAGCGCCATCACTGGTTCACAGAGGCGAAAGGAGAGTCCAGTGAGAAACCAGCCATT
GTCTTCATGTACAGGTGCGACCCTGCTCAAGGCCAGCTCAGTGTGGATCAGAGCAAGGCTAGGACAGACCAGGCAGCAGTCATGGAGAAG
GGTAGAGCAGAGAATGCATTACTACAGGACTCAGAGAAGAAGAGGAGTCATTCTTCTCCATCACAGATTCCTAAAAAGATTCTCAGCTCC
CTGAGGGCCTCCTTTGACTCCTTGAAGCAGCAAATGGAGAATGTGGGCAGCTCACACATCCAGCTGGCCCTGACCCTGCGTGAGGAGCTG
CGGAGTCTCGAGGAGTTTCGTGAGAGGCAGAAGGAGCAGAGGAAGAAGTATGAGGCCGTCATGGACCGGGTCCAGAAGAGCAAGCTGTCG
CTCTACAAGAAGGCCATGGAGTCCAAGAAGACATACGAGCAGAAGTGCCGGGACGCGGACGACGCGGAGCAGGCCTTCGAGCGCATTAGC
GCCAACGGCCACCAGAAGCAGGTGGAGAAGAGTCAGAACAAAGCCAGGCAGTGCAAGGACTCGGCCACCGAGGCAGAGCGGGTATACAGG
CAGAGCATTGCGCAGCTGGAGAAGGTCCGGGCTGAGTGGGAGCAGGAGCACCGGACCACCTGTGAGGCCTTTCAGCTGCAAGAGTTTGAC
CGGCTGACCATTCTCCGCAACGCCCTGTGGGTGCACAGCAACCAGCTCTCCATGCAGTGTGTCAAGGATGATGAGCTCTACGAGGAAGTG
CGGCTGACGCTGGAAGGCTGCAGCATAGACGCCGACATCGACAGTTTCATCCAGGCCAAGAGCACGGGCACAGAGCCCCCCGGTGAGGTC
CGGCTTGCGGACAGCGCAGCCTCTAGGTTCTCTGGACTGCTGCACGGAAGTCCCAAGACCACTTCGTTGGCAGCTTCTGCTGCGTCCACA
GAGACCCTGACCCCCACCCCCGAGCGGAATGAGGGTGTCTACACAGCCATCGCAGTGCAGGAGATACAGGGAAACCCGGCCTCACCAGCC
CAGGAGTACCGGGCGCTCTACGATTATACAGCGCAGAACCCAGATGAGCTGGACCTGTCCGCGGGAGACATCCTGGAGGTGATCCTGGAA
GGGGAGGATGGCTGGTGGACTGTGGAGAGGAACGGGCAGCGTGGCTTCGTCCCTGGTTCCTACCTGGAGAAGCTTTGAGGAAGGGCCAGG
AGCCCCTTCGGACCTGCCCTGCCAGTGGAGCCAGCAGTGCCCCCAGCACTGTCCCCACCTTGCTAGGGCCCAGAACCAAGCGTCCCCCAG

>64203_64203_4_PEAK1-PSTPIP1_PEAK1_chr15_77471132_ENST00000312493_PSTPIP1_chr15_77317625_ENST00000559295_length(amino acids)=1372AA_BP=1035
MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDPEKAPITHGNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGELS
IQEHCENKPVIIGWNRNRAALSQKPLNNNNEDDEGISHVPKPYGNNDSAKKMSDNNNGLTEVLKEIAGLDTAPQIRGNETNSRETFLGRI
NDCYKRSLERKLPPSCMIGGIKETQGKHVILSGSTEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQP
RFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSVVSYGQGSIQSMVSSDSTSPDSSLTEESRSETASSL
SQKICNGGLSPGNPGDSKDMKEIEPNYESPSSNNQDKDSSQASKSSIKVPETHKAVLALRLEEKDGKIAVQTEKEESKASTDVAGQAVTI
NLVPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAMASEHLEGPVNSPKTKSSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTS
PRQKIPKVELITSGTGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPTYARSSKNAIKVPIVI
NPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVPDNTTSKTTDCLQTKGFSNSTEHKRGSVAQKVQEFNNCLNRGQSSP
QRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVGSSSTREKASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTP
KSTPVRPKSLFTSQPSGEAEAPQTTDSPTTKVQKDPSIKPVTPSPSKLVTSPQSEPPAPFPPPRSTSSPYHAGNLLQRHFTNWTKPTSPT
RSTEAESVLHSEGSRRAADAKPKRWISFKSFFRRRKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFM
YRCDPAQGQLSVDQSKARTDQAAVMEKGRAENALLQDSEKKRSHSSPSQIPKKILSSLRASFDSLKQQMENVGSSHIQLALTLREELRSL
EEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKDSATEAERVYRQSI
AQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPGEVRLA
DSAASRFSGLLHGSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGED

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Fusion Gene PPI Analysis for PEAK1-PSTPIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PEAK1-PSTPIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PEAK1-PSTPIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource