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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARID1B-TIAM2 (FusionGDB2 ID:6424)

Fusion Gene Summary for ARID1B-TIAM2

Fusion gene summary

Fusion gene information	Fusion gene name: ARID1B-TIAM2
	Fusion gene ID: 6424
		Hgene	Tgene
	Gene symbol	ARID1B	TIAM2
	Gene ID	57492	26230
	Gene name	AT-rich interaction domain 1B	TIAM Rac1 associated GEF 2
	Synonyms	6A3-5\|BAF250B\|BRIGHT\|CSS1\|DAN15\|ELD/OSA1\|MRD12\|OSA2\|P250R	STEF\|TIAM-2
	Cytomap	6q25.3	6q25.2-q25.3
	Type of gene	protein-coding	protein-coding
	Description	AT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein	T-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factorT cell lymphoma invasion and metastasis 2
	Modification date	20200320	20200313
	UniProtAcc	Q8NFD5	.
	Ensembl transtripts involved in fusion gene	ENST00000478761, ENST00000275248, ENST00000346085, ENST00000350026, ENST00000367148,	ENST00000461783, ENST00000275246, ENST00000318981, ENST00000360366, ENST00000367174, ENST00000449545, ENST00000456144, ENST00000456877, ENST00000528391, ENST00000529824,
Fusion gene scores	* DoF score	27 X 18 X 14=6804	18 X 17 X 10=3060
	# samples	31	23
	** MAII score	log2(31/6804*10)=-4.45604302038915 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/3060*10)=-3.73382588663564 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARID1B [Title/Abstract] AND TIAM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARID1B(157100605)-TIAM2(155411423), # samples:2 ARID1B(157470085)-TIAM2(155265250), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ARID1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TIAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-19-5960-01A	ARID1B	chr6	157100605	-	TIAM2	chr6	155411423	+
ChimerDB4	GBM	TCGA-19-5960-01A	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
ChimerDB4	LUSC	TCGA-85-7950-01A	ARID1B	chr6	157470085	-	TIAM2	chr6	155265250	+
ChimerDB4	LUSC	TCGA-85-7950	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
ChimerDB4	LUSC	TCGA-85-7950	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+

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Fusion Gene ORF analysis for ARID1B-TIAM2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-5UTR	ENST00000478761	ENST00000461783	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000275246	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000318981	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000360366	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000367174	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000449545	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000456144	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000456877	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000528391	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
3UTR-intron	ENST00000478761	ENST00000529824	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-5UTR	ENST00000275248	ENST00000461783	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-5UTR	ENST00000275248	ENST00000461783	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-5UTR	ENST00000275248	ENST00000461783	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-5UTR	ENST00000346085	ENST00000461783	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-5UTR	ENST00000346085	ENST00000461783	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-5UTR	ENST00000346085	ENST00000461783	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-5UTR	ENST00000350026	ENST00000461783	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-5UTR	ENST00000350026	ENST00000461783	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-5UTR	ENST00000350026	ENST00000461783	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-5UTR	ENST00000367148	ENST00000461783	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-5UTR	ENST00000367148	ENST00000461783	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-5UTR	ENST00000367148	ENST00000461783	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000275246	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000275246	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000275246	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000318981	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000318981	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000318981	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000360366	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000360366	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000360366	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000367174	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000367174	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000367174	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000449545	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000449545	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000449545	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000456144	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000456144	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000456144	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000456877	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000456877	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000456877	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000528391	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000528391	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000528391	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000529824	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000275248	ENST00000529824	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000275248	ENST00000529824	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000275246	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000275246	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000275246	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000318981	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000318981	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000318981	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000360366	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000360366	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000360366	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000367174	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000367174	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000367174	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000449545	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000449545	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000449545	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000456144	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000456144	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000456144	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000456877	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000456877	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000456877	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000528391	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000528391	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000528391	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000529824	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000346085	ENST00000529824	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000346085	ENST00000529824	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000275246	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000275246	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000275246	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000318981	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000318981	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000318981	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000360366	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000360366	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000360366	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000367174	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000367174	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000367174	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000449545	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000449545	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000449545	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000456144	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000456144	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000456144	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000456877	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000456877	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000456877	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000528391	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000528391	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000528391	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000529824	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000350026	ENST00000529824	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000350026	ENST00000529824	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000275246	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000275246	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000275246	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000318981	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000318981	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000318981	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000360366	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000360366	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000360366	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000367174	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000367174	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000367174	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000449545	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000449545	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000449545	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000456144	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000456144	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000456144	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000456877	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000456877	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000456877	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000528391	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000528391	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000528391	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000529824	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
5CDS-intron	ENST00000367148	ENST00000529824	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
5CDS-intron	ENST00000367148	ENST00000529824	ARID1B	chr6	157470085	+	TIAM2	chr6	155265250	+
intron-5UTR	ENST00000478761	ENST00000461783	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-5UTR	ENST00000478761	ENST00000461783	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000275246	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000275246	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000318981	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000318981	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000360366	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000360366	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000367174	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000367174	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000449545	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000449545	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000456144	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000456144	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000456877	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000456877	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000528391	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000528391	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+
intron-intron	ENST00000478761	ENST00000529824	ARID1B	chr6	157100605	+	TIAM2	chr6	155411423	+
intron-intron	ENST00000478761	ENST00000529824	ARID1B	chr6	157454341	+	TIAM2	chr6	155265250	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ARID1B-TIAM2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ARID1B	chr6	157454341	+	TIAM2	chr6	155265249	+	0.93969893	0.060301002
ARID1B	chr6	157470085	+	TIAM2	chr6	155265249	+	0.0258306	0.97416943
ARID1B	chr6	157100605	+	TIAM2	chr6	155411422	+	8.68E-08	0.9999999
ARID1B	chr6	157454341	+	TIAM2	chr6	155265249	+	0.93969893	0.060301002
ARID1B	chr6	157470085	+	TIAM2	chr6	155265249	+	0.0258306	0.97416943
ARID1B	chr6	157100605	+	TIAM2	chr6	155411422	+	8.68E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARID1B-TIAM2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:157100605/:155411423)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARID1B Q8NFD5	.
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250\|UniProtKB:E9Q4N7, ECO:0000269\|PubMed:14982958, ECO:0000269\|PubMed:15170388, ECO:0000303\|PubMed:12672490, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ARID1B-TIAM2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARID1B-TIAM2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARID1B-TIAM2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARID1B-TIAM2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source