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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:PELI2-KTN1 (FusionGDB2 ID:64255)

Fusion Gene Summary for PELI2-KTN1

Fusion gene summary

Fusion gene information	Fusion gene name: PELI2-KTN1
	Fusion gene ID: 64255
		Hgene	Tgene
	Gene symbol	PELI2	KTN1
	Gene ID	57161	3895
	Gene name	pellino E3 ubiquitin protein ligase family member 2	kinectin 1
	Synonyms	-	CG1\|KNT\|MU-RMS-40.19
	Cytomap	14q22.3	14q22.3
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase pellino homolog 2RING-type E3 ubiquitin transferase pellino homolog 2pellino homolog 2pellino-2protein pellino homolog 2	kinectinCG-1 antigenkinesin receptor
	Modification date	20200313	20200313
	UniProtAcc	.	Q86SY8
	Ensembl transtripts involved in fusion gene	ENST00000267460,	ENST00000555573, ENST00000395308, ENST00000395309, ENST00000395311, ENST00000395314, ENST00000413890, ENST00000416613, ENST00000438792, ENST00000554507,
Fusion gene scores	* DoF score	9 X 5 X 6=270	18 X 20 X 7=2520
	# samples	10	22
	** MAII score	log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2520*10)=-3.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PELI2 [Title/Abstract] AND KTN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PELI2(56585455)-KTN1(56122760), # samples:2 KTN1(56146403)-PELI2(56763318), # samples:1
Anticipated loss of major functional domain due to fusion event.	KTN1-PELI2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KTN1-PELI2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PELI2-KTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PELI2-KTN1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PELI2	GO:0001934	positive regulation of protein phosphorylation	12804775
Hgene	PELI2	GO:0043410	positive regulation of MAPK cascade	12804775

Fusion gene breakpoints across PELI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KTN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-AX-A2H4-01A	PELI2	chr14	56585455	-	KTN1	chr14	56122760	+
ChimerDB4	UCEC	TCGA-AX-A2H4-01A	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
ChimerDB4	UCEC	TCGA-DI-A1NO-01A	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+

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Fusion Gene ORF analysis for PELI2-KTN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000267460	ENST00000555573	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
5CDS-intron	ENST00000267460	ENST00000555573	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
Frame-shift	ENST00000267460	ENST00000395308	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
Frame-shift	ENST00000267460	ENST00000395309	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
Frame-shift	ENST00000267460	ENST00000395311	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
Frame-shift	ENST00000267460	ENST00000395314	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
Frame-shift	ENST00000267460	ENST00000413890	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
Frame-shift	ENST00000267460	ENST00000416613	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
Frame-shift	ENST00000267460	ENST00000438792	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
Frame-shift	ENST00000267460	ENST00000554507	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+
In-frame	ENST00000267460	ENST00000395308	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
In-frame	ENST00000267460	ENST00000395309	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
In-frame	ENST00000267460	ENST00000395311	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
In-frame	ENST00000267460	ENST00000395314	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
In-frame	ENST00000267460	ENST00000413890	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
In-frame	ENST00000267460	ENST00000416613	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
In-frame	ENST00000267460	ENST00000438792	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
In-frame	ENST00000267460	ENST00000554507	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000267460	PELI2	chr14	56585455	+	ENST00000395309	KTN1	chr14	56122760	+	1636	363	286	1635	450
ENST00000267460	PELI2	chr14	56585455	+	ENST00000413890	KTN1	chr14	56122760	+	2032	363	286	1551	421
ENST00000267460	PELI2	chr14	56585455	+	ENST00000438792	KTN1	chr14	56122760	+	1941	363	286	1464	392
ENST00000267460	PELI2	chr14	56585455	+	ENST00000395314	KTN1	chr14	56122760	+	2112	363	286	1635	449
ENST00000267460	PELI2	chr14	56585455	+	ENST00000395308	KTN1	chr14	56122760	+	1580	363	286	1551	421
ENST00000267460	PELI2	chr14	56585455	+	ENST00000395311	KTN1	chr14	56122760	+	2028	363	286	1551	421
ENST00000267460	PELI2	chr14	56585455	+	ENST00000416613	KTN1	chr14	56122760	+	2172	363	286	1635	449
ENST00000267460	PELI2	chr14	56585455	+	ENST00000554507	KTN1	chr14	56122760	+	1622	363	286	1464	392

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000267460	ENST00000395309	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.003410162	0.9965899
ENST00000267460	ENST00000413890	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.00079478	0.9992053
ENST00000267460	ENST00000438792	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.000819098	0.99918085
ENST00000267460	ENST00000395314	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.000862006	0.999138
ENST00000267460	ENST00000395308	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.002982181	0.99701786
ENST00000267460	ENST00000395311	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.000805297	0.9991947
ENST00000267460	ENST00000416613	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.000868705	0.99913126
ENST00000267460	ENST00000554507	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.001610784	0.99838924

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Fusion Genomic Features for PELI2-KTN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PELI2	chr14	56585455	+	KTN1	chr14	56122759	+	0.001041095	0.99895895
PELI2	chr14	56645182	+	KTN1	chr14	56119567	+	5.49E-07	0.9999994
PELI2	chr14	56585455	+	KTN1	chr14	56122759	+	0.001041095	0.99895895
PELI2	chr14	56645182	+	KTN1	chr14	56119567	+	5.49E-07	0.9999994

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PELI2-KTN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:56585455/chr14:56122760)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KTN1 Q86SY8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PELI2

chr14:56585455

chr14:56122760

ENST00000267460

15_202

421.0

Domain

Note=FHA%3B atypical

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395308

330_1356

910

1307.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395309

330_1356

933

1358.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395311

330_1356

910

1307.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395314

330_1356

933

1358.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000413890

330_1356

910

1307.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000416613

330_1356

933

1321.3333333333333

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000438792

330_1356

933

1301.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395308

1_6

910

1307.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395308

30_1357

910

1307.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395309

1_6

933

1358.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395309

30_1357

933

1358.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395311

1_6

910

1307.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395311

30_1357

910

1307.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395314

1_6

933

1358.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395314

30_1357

933

1358.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000413890

1_6

910

1307.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000413890

30_1357

910

1307.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000416613

1_6

933

1321.3333333333333

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000416613

30_1357

933

1321.3333333333333

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000438792

1_6

933

1301.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000438792

30_1357

933

1301.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395308

7_29

910

1307.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395309

7_29

933

1358.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395311

7_29

910

1307.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395314

7_29

933

1358.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000413890

7_29

910

1307.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000416613

7_29

933

1321.3333333333333

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000438792

7_29

933

1301.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for PELI2-KTN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64255_64255_1_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395308_length(transcript)=1580nt_BP=363nt
GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG
AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC
GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC
GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT
CGGGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAGTGATCTTTCTAGCAAAACACAGCTGTT
ACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAACTACCAACAGGCATCTTCTTTTCCCCC
TCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGA
ACACCAGAGGAAGAAAAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGCATCAACTGAAAAAATGCTGCAGGACAA
AGTGAACAAGACTTCCAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAAGGT
GTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTCAGA
GGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGTCCT
TGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACACAA
GACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCTGAG
AAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGTTGAAGGCACA
GTTAAATGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACTGGA
GCTTATCCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGAGAA
GGAGACAATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAAAGA

>64255_64255_1_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395308_length(amino acids)=421AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK

--------------------------------------------------------------
>64255_64255_2_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395309_length(transcript)=1636nt_BP=363nt
GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG
AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC
GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC
GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT
CGGGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAGTGATCTTTCTAGCAAAACACAGCTGTT
ACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAACTACCAACAGGCATCTTCTTTTCCCCC
TCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGA
ACACCAGAGGAAGAAAAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGCATCAACTGAAAAAATGCTGCAGGACAA
AGTGAACAAGACTTCCAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAAGGT
GTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTCAGA
GGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGTCCT
TGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACACAA
GACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCTGAG
AAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGCTGAAAGATCT
GTTGACTGAATTGCAGAAAAAACTTGATGATTCATATTCTGAAGCAGTAAGACAGAATGAAGAGCTAAATTTGTTGAAGGCACAGTTAAA
TGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACTGGAGCTTAT
CCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGAGAAGGAGAC
AATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAAAGAGCACTA

>64255_64255_2_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395309_length(amino acids)=450AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK
LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLEX

--------------------------------------------------------------
>64255_64255_3_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395311_length(transcript)=2028nt_BP=363nt
GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG
AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC
GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC
GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT
CGGGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAGTGATCTTTCTAGCAAAACACAGCTGTT
ACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAACTACCAACAGGCATCTTCTTTTCCCCC
TCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGA
ACACCAGAGGAAGAAAAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGCATCAACTGAAAAAATGCTGCAGGACAA
AGTGAACAAGACTTCCAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAAGGT
GTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTCAGA
GGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGTCCT
TGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACACAA
GACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCTGAG
AAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGTTGAAGGCACA
GTTAAATGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACTGGA
GCTTATCCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGAGAA
GGAGACAATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAAAGA
GCACTACCAGGTGTTAGAGTGAAGTAATTGGGAAACTGTTCATTTGAGGATAAAAAAGGCATTGTATTATATTTTGCCAAATTAAAGCCT
TATTTATGTTTTCACCCTTTCTACTTTGTCAGAAACACTGAACAGAGTTTTGTCTTTTCTAATCCTTGTTAGACTACTGATTTAAAGAAG
GAAAAAAAAAAGCCAACTCTGTAGACACCTTCAGAGTTTAGTTTTATAATAAAAACTGTTTGAATAATTAGACCTTTACATTCCTGAAGA
TAAACATGTAATCTTTTATCTTATTTTGCTCAATAAAATTGTTCAGAAGATCAAAGTGGTAAAGACAATGTAAAATTTAACATTTTAATA
CTGATGTTGTACACTGTTTTACTTAACATTTTGGGAAGTAACTGCCTCTGACTTCAACTCAAGAAAACACTTTTTTGTTGCTAATGTAAT

>64255_64255_3_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395311_length(amino acids)=421AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK

--------------------------------------------------------------
>64255_64255_4_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395314_length(transcript)=2112nt_BP=363nt
GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG
AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC
GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC
GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT
CGGGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAGTGATCTTTCTAGCAAAACACAGCTGTT
ACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAACTACCAACAGGCATCTTCTTTTCCCCC
TCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGA
ACACCAGAGGAAGAAAAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGCATCAACTGAAAAAATGCTGCAGGACAA
AGTGAACAAGACTTCCAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAAGGT
GTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTCAGA
GGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGTCCT
TGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACACAA
GACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCTGAG
AAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGCTGAAAGATCT
GTTGACTGAATTGCAGAAAAAACTTGATGATTCATATTCTGAAGCAGTAAGACAGAATGAAGAGCTAAATTTGTTGAAGGCACAGTTAAA
TGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACTGGAGCTTAT
CCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGAGAAGGAGAC
AATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAAAGAGCACTA
CCAGGTGTTAGAGTGAAGTAATTGGGAAACTGTTCATTTGAGGATAAAAAAGGCATTGTATTATATTTTGCCAAATTAAAGCCTTATTTA
TGTTTTCACCCTTTCTACTTTGTCAGAAACACTGAACAGAGTTTTGTCTTTTCTAATCCTTGTTAGACTACTGATTTAAAGAAGGAAAAA
AAAAAGCCAACTCTGTAGACACCTTCAGAGTTTAGTTTTATAATAAAAACTGTTTGAATAATTAGACCTTTACATTCCTGAAGATAAACA
TGTAATCTTTTATCTTATTTTGCTCAATAAAATTGTTCAGAAGATCAAAGTGGTAAAGACAATGTAAAATTTAACATTTTAATACTGATG
TTGTACACTGTTTTACTTAACATTTTGGGAAGTAACTGCCTCTGACTTCAACTCAAGAAAACACTTTTTTGTTGCTAATGTAATCGGTTT

>64255_64255_4_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395314_length(amino acids)=449AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK

--------------------------------------------------------------
>64255_64255_5_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000413890_length(transcript)=2032nt_BP=363nt
GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG
AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC
GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC
GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT
CGGGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAGTGATCTTTCTAGCAAAACACAGCTGTT
ACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAACTACCAACAGGCATCTTCTTTTCCCCC
TCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGA
ACACCAGAGGAAGAAAAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGCATCAACTGAAAAAATGCTGCAGGACAA
AGTGAACAAGACTTCCAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAAGGT
GTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTCAGA
GGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGTCCT
TGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACACAA
GACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCTGAG
AAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGTTGAAGGCACA
GTTAAATGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACTGGA
GCTTATCCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGAGAA
GGAGACAATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAAAGA
GCACTACCAGGTGTTAGAGTGAAGTAATTGGGAAACTGTTCATTTGAGGATAAAAAAGGCATTGTATTATATTTTGCCAAATTAAAGCCT
TATTTATGTTTTCACCCTTTCTACTTTGTCAGAAACACTGAACAGAGTTTTGTCTTTTCTAATCCTTGTTAGACTACTGATTTAAAGAAG
GAAAAAAAAAAGCCAACTCTGTAGACACCTTCAGAGTTTAGTTTTATAATAAAAACTGTTTGAATAATTAGACCTTTACATTCCTGAAGA
TAAACATGTAATCTTTTATCTTATTTTGCTCAATAAAATTGTTCAGAAGATCAAAGTGGTAAAGACAATGTAAAATTTAACATTTTAATA
CTGATGTTGTACACTGTTTTACTTAACATTTTGGGAAGTAACTGCCTCTGACTTCAACTCAAGAAAACACTTTTTTGTTGCTAATGTAAT

>64255_64255_5_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000413890_length(amino acids)=421AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK

--------------------------------------------------------------
>64255_64255_6_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000416613_length(transcript)=2172nt_BP=363nt
GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG
AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC
GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC
GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT
CGGGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAGTGATCTTTCTAGCAAAACACAGCTGTT
ACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAACTACCAACAGGCATCTTCTTTTCCCCC
TCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGA
ACACCAGAGGAAGAAAAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGCATCAACTGAAAAAATGCTGCAGGACAA
AGTGAACAAGACTTCCAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAAGGT
GTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTCAGA
GGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGTCCT
TGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACACAA
GACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCTGAG
AAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGCTGAAAGATCT
GTTGACTGAATTGCAGAAAAAACTTGATGATTCATATTCTGAAGCAGTAAGACAGAATGAAGAGCTAAATTTGTTGAAGGCACAGTTAAA
TGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACTGGAGCTTAT
CCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGAGAAGGAGAC
AATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAAAGAGCACTA
CCAGGTGTTAGAGTGATCATCCTCTGGCCTACCTTGACACATGCTCTCCTTCAAAATGCTAATTCAGAGTGAAGTAATTGGGAAACTGTT
CATTTGAGGATAAAAAAGGCATTGTATTATATTTTGCCAAATTAAAGCCTTATTTATGTTTTCACCCTTTCTACTTTGTCAGAAACACTG
AACAGAGTTTTGTCTTTTCTAATCCTTGTTAGACTACTGATTTAAAGAAGGAAAAAAAAAAGCCAACTCTGTAGACACCTTCAGAGTTTA
GTTTTATAATAAAAACTGTTTGAATAATTAGACCTTTACATTCCTGAAGATAAACATGTAATCTTTTATCTTATTTTGCTCAATAAAATT
GTTCAGAAGATCAAAGTGGTAAAGACAATGTAAAATTTAACATTTTAATACTGATGTTGTACACTGTTTTACTTAACATTTTGGGAAGTA
ACTGCCTCTGACTTCAACTCAAGAAAACACTTTTTTGTTGCTAATGTAATCGGTTTTTGTAATGGCGTCAGCAAATAAAAGGATGCTTAT

>64255_64255_6_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000416613_length(amino acids)=449AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK

--------------------------------------------------------------
>64255_64255_7_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000438792_length(transcript)=1941nt_BP=363nt
GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG
AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC
GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC
GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT
CGGGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAGTGATCTTTCTAGCAAAACACAGCTGTT
ACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAACTACCAACAGGCATCTTCTTTTCCCCC
TCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGA
ACACCAGAGGAAGAAAAACAATGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAA
GGTGTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTC
AGAGGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGT
CCTTGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACA
CAAGACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCT
GAGAAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGTTGAAGGC
ACAGTTAAATGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACT
GGAGCTTATCCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGA
GAAGGAGACAATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAA
AGAGCACTACCAGGTGTTAGAGTGAAGTAATTGGGAAACTGTTCATTTGAGGATAAAAAAGGCATTGTATTATATTTTGCCAAATTAAAG
CCTTATTTATGTTTTCACCCTTTCTACTTTGTCAGAAACACTGAACAGAGTTTTGTCTTTTCTAATCCTTGTTAGACTACTGATTTAAAG
AAGGAAAAAAAAAAGCCAACTCTGTAGACACCTTCAGAGTTTAGTTTTATAATAAAAACTGTTTGAATAATTAGACCTTTACATTCCTGA
AGATAAACATGTAATCTTTTATCTTATTTTGCTCAATAAAATTGTTCAGAAGATCAAAGTGGTAAAGACAATGTAAAATTTAACATTTTA
ATACTGATGTTGTACACTGTTTTACTTAACATTTTGGGAAGTAACTGCCTCTGACTTCAACTCAAGAAAACACTTTTTTGTTGCTAATGT

>64255_64255_7_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000438792_length(amino acids)=392AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV
LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE
HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS

--------------------------------------------------------------
>64255_64255_8_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000554507_length(transcript)=1622nt_BP=363nt
GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG
AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC
GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC
GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT
CGGGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAGTGATCTTTCTAGCAAAACACAGCTGTT
ACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAACTACCAACAGGCATCTTCTTTTCCCCC
TCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGA
ACACCAGAGGAAGAAAAACAATGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAA
GGTGTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTC
AGAGGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGT
CCTTGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACA
CAAGACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCT
GAGAAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGTTGAAGGC
ACAGTTAAATGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACT
GGAGCTTATCCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGA
GAAGGAGACAATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAA
AGAGCACTACCAGGTGTTAGAGTGAAGTAATTGGGAAACTGTTCATTTGAGGATAAAAAAGGCATTGTATTATATTTTGCCAAATTAAAG
CCTTATTTATGTTTTCACCCTTTCTACTTTGTCAGAAACACTGAACAGAGTTTTGTCTTTTCTAATCCTTGTTAGACTACTGATTTAAAG

>64255_64255_8_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000554507_length(amino acids)=392AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV
LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE
HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS

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Fusion Gene PPI Analysis for PELI2-KTN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PELI2-KTN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PELI2-KTN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source