FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PELP1-CHRNE (FusionGDB2 ID:64264)

Fusion Gene Summary for PELP1-CHRNE

check button Fusion gene summary
Fusion gene informationFusion gene name: PELP1-CHRNE
Fusion gene ID: 64264
HgeneTgene
Gene symbol

PELP1

CHRNE

Gene ID

27043

1145

Gene nameproline, glutamate and leucine rich protein 1cholinergic receptor nicotinic epsilon subunit
SynonymsMNAR|P160ACHRE|CMS1D|CMS1E|CMS2A|CMS4A|CMS4B|CMS4C|FCCMS|SCCMS
Cytomap

17p13.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionproline-, glutamic acid- and leucine-rich protein 1modulator of non-genomic activity of estrogen receptorproline and glutamic acid rich nuclear proteintranscription factor HMX3acetylcholine receptor subunit epsilonAchR epsilon subunitacetylcholine receptor, nicotinic, epsilon (muscle)cholinergic receptor, nicotinic epsiloncholinergic receptor, nicotinic, epsilon (muscle)cholinergic receptor, nicotinic, epsilon polypeptide
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269230, ENST00000301396, 
ENST00000436683, ENST00000572293, 
ENST00000574876, ENST00000570823, 
ENST00000575637, ENST00000293780, 
Fusion gene scores* DoF score4 X 5 X 4=802 X 2 X 2=8
# samples 63
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: PELP1 [Title/Abstract] AND CHRNE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPELP1(4579652)-CHRNE(4806058), # samples:2
Anticipated loss of major functional domain due to fusion event.PELP1-CHRNE seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PELP1-CHRNE seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePELP1

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

HgenePELP1

GO:0071391

cellular response to estrogen stimulus

17505058


check buttonFusion gene breakpoints across PELP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHRNE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-18-4083-01APELP1chr17

4607158

-CHRNEchr17

4806058

-
ChimerDB4LUSCTCGA-60-2719-01APELP1chr17

4579652

-CHRNEchr17

4806058

-
ChimerDB4LUSCTCGA-60-2719PELP1chr17

4579652

-CHRNEchr17

4806058

-


Top

Fusion Gene ORF analysis for PELP1-CHRNE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000269230ENST00000575637PELP1chr17

4607158

-CHRNEchr17

4806058

-
5CDS-intronENST00000269230ENST00000575637PELP1chr17

4579652

-CHRNEchr17

4806058

-
5CDS-intronENST00000301396ENST00000575637PELP1chr17

4607158

-CHRNEchr17

4806058

-
5CDS-intronENST00000301396ENST00000575637PELP1chr17

4579652

-CHRNEchr17

4806058

-
5CDS-intronENST00000436683ENST00000575637PELP1chr17

4579652

-CHRNEchr17

4806058

-
5CDS-intronENST00000572293ENST00000575637PELP1chr17

4607158

-CHRNEchr17

4806058

-
5CDS-intronENST00000572293ENST00000575637PELP1chr17

4579652

-CHRNEchr17

4806058

-
5CDS-intronENST00000574876ENST00000575637PELP1chr17

4607158

-CHRNEchr17

4806058

-
5CDS-intronENST00000574876ENST00000575637PELP1chr17

4579652

-CHRNEchr17

4806058

-
5UTR-3CDSENST00000436683ENST00000293780PELP1chr17

4607158

-CHRNEchr17

4806058

-
5UTR-3CDSENST00000570823ENST00000293780PELP1chr17

4607158

-CHRNEchr17

4806058

-
5UTR-intronENST00000436683ENST00000575637PELP1chr17

4607158

-CHRNEchr17

4806058

-
5UTR-intronENST00000570823ENST00000575637PELP1chr17

4607158

-CHRNEchr17

4806058

-
Frame-shiftENST00000269230ENST00000293780PELP1chr17

4607158

-CHRNEchr17

4806058

-
Frame-shiftENST00000301396ENST00000293780PELP1chr17

4607158

-CHRNEchr17

4806058

-
Frame-shiftENST00000436683ENST00000293780PELP1chr17

4579652

-CHRNEchr17

4806058

-
Frame-shiftENST00000572293ENST00000293780PELP1chr17

4607158

-CHRNEchr17

4806058

-
Frame-shiftENST00000574876ENST00000293780PELP1chr17

4607158

-CHRNEchr17

4806058

-
In-frameENST00000269230ENST00000293780PELP1chr17

4579652

-CHRNEchr17

4806058

-
In-frameENST00000301396ENST00000293780PELP1chr17

4579652

-CHRNEchr17

4806058

-
In-frameENST00000572293ENST00000293780PELP1chr17

4579652

-CHRNEchr17

4806058

-
In-frameENST00000574876ENST00000293780PELP1chr17

4579652

-CHRNEchr17

4806058

-
intron-3CDSENST00000570823ENST00000293780PELP1chr17

4579652

-CHRNEchr17

4806058

-
intron-intronENST00000570823ENST00000575637PELP1chr17

4579652

-CHRNEchr17

4806058

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000574876PELP1chr174579652-ENST00000293780CHRNEchr174806058-3269871182306762
ENST00000572293PELP1chr174579652-ENST00000293780CHRNEchr174806058-34651067492502817
ENST00000269230PELP1chr174579652-ENST00000293780CHRNEchr174806058-34771079612514817
ENST00000301396PELP1chr174579652-ENST00000293780CHRNEchr174806058-34771079612514817

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000574876ENST00000293780PELP1chr174579652-CHRNEchr174806058-0.0214412920.97855866
ENST00000572293ENST00000293780PELP1chr174579652-CHRNEchr174806058-0.0209172950.97908264
ENST00000269230ENST00000293780PELP1chr174579652-CHRNEchr174806058-0.0213354510.9786646
ENST00000301396ENST00000293780PELP1chr174579652-CHRNEchr174806058-0.0213354510.9786646

Top

Fusion Genomic Features for PELP1-CHRNE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PELP1-CHRNE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:4579652/chr17:4806058)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717111_1152841131.0MotifNote=LXXLL motif 3
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717155_1592841131.0MotifNote=LXXLL motif 4
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717177_1812841131.0MotifNote=LXXLL motif 5
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717264_2682841131.0MotifNote=LXXLL motif 6
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717271_2752841131.0MotifNote=LXXLL motif 7
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-71733_372841131.0MotifNote=LXXLL motif 1
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-71769_732841131.0MotifNote=LXXLL motif 2
TgeneCHRNEchr17:4579652chr17:4806058ENST0000029378001221_23915494.0Topological domainExtracellular
TgeneCHRNEchr17:4579652chr17:4806058ENST00000293780012265_27215494.0Topological domainCytoplasmic
TgeneCHRNEchr17:4579652chr17:4806058ENST00000293780012292_30615494.0Topological domainExtracellular
TgeneCHRNEchr17:4579652chr17:4806058ENST00000293780012329_45615494.0Topological domainCytoplasmic
TgeneCHRNEchr17:4579652chr17:4806058ENST00000293780012481_49315494.0Topological domainExtracellular
TgeneCHRNEchr17:4579652chr17:4806058ENST00000293780012240_26415494.0TransmembraneHelical
TgeneCHRNEchr17:4579652chr17:4806058ENST00000293780012273_29115494.0TransmembraneHelical
TgeneCHRNEchr17:4579652chr17:4806058ENST00000293780012307_32815494.0TransmembraneHelical
TgeneCHRNEchr17:4579652chr17:4806058ENST00000293780012457_48015494.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717633_8722841131.0Compositional biasNote=Pro-rich
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717888_11012841131.0Compositional biasNote=Glu-rich
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717977_10832841131.0Compositional biasNote=Pro-rich
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717364_3682841131.0MotifNote=LXXLL motif 8
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717459_4632841131.0MotifNote=LXXLL motif 9
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717579_5832841131.0MotifNote=LXXLL motif 10
HgenePELP1chr17:4579652chr17:4806058ENST00000574876-717584_5882841131.0MotifNote=LXXLL motif 11


Top

Fusion Gene Sequence for PELP1-CHRNE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64264_64264_1_PELP1-CHRNE_PELP1_chr17_4579652_ENST00000269230_CHRNE_chr17_4806058_ENST00000293780_length(transcript)=3477nt_BP=1079nt
ACAGGCAGCCTCATCCGCCATCACTCCGGGAACCGAGCACCCCGCTGCCTCGGCGCCCAGGCTGCTCTCTCCGCGCATGCTCCTTCCCAG
CTTGAGCCCGCGAGTCCAGCCTGCCTTCACTCAGTGCGCAAGACCGCAGCCCCCTCCCCACGCCCCCTCCCCAGTAGGCGGCCGTCGCGG
TGTGTTTGCGTCATCGCGCCACGCCACCACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGC
TGGGGTTCCTGGCGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCT
GCAACCTCGAACGGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCT
GCATGGGTCGGTGGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCG
GTTTGAGGGCCTGTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCAT
TCAGCAGGTGTTACAGACCCAGGACCCGCCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCT
GCCTGCACTGTTCCGGGACATCTCCATGAACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGC
ATTGGAAGGAATGAAGGCTTGTATGACCTATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGT
GGATGCCTTGAGCCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAA
GCACACCGAGAGCTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGG
CAGGGGTGTGGGGAAGAACGAGGAACTGCGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGA
GGATACTGTCACCATCAGCCTCAAGGTCACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGAT
TGGAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTG
GCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGT
GACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTT
CCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACAC
AGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGG
GGAGACTGACGTCATCTACTCGCTCATCATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGG
CCTGGTGCTGCTCGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTT
CTTGTTCCTCATTGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCAC
GCTCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCT
CCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGG
CTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGAC
GGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGA
TCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTT
CAGCGTGGGCTCCAGCCTCATCTTCCTCGGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGC
ACCGACTTCAATTTCCCACCCATCTCCAGTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCT
GCTGATCAATCTGCAGTTTGTGAACTTCACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGC
AGGAGGAAAGGGTTCACATAGGCTCTCAGGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTCCCAGCCTT
TCTAAGGCTCAGCCCCACGGGACTCTGGTGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGCCAAACAGGAGACCCCTTT
GCAGGACTTGCACACAGGGAGGCTGTAGCCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTGCTGGAGCGGGTGGGAACCAAACACCTTC
AGTGCTGGTGGCCCTCAGGCCCACAGGTTTAAGGCTGAGGCTGCCCTGACCCTTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCA
CTGCCCATCCCACCCCATGAGGCTCACTCATTGCAGATCCCAGCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAG
TCTACAGTACTGACAGAAAGCAAGGACATGCGGCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCC
ACTACATTGAGGAGGGGTGGGGGGGGAGGGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAG
GGCTCCCTGCTCCCTCCCTCCACCGGGGAAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGGG

>64264_64264_1_PELP1-CHRNE_PELP1_chr17_4579652_ENST00000269230_CHRNE_chr17_4806058_ENST00000293780_length(amino acids)=817AA_BP=339
MLSPRMLLPSLSPRVQPAFTQCARPQPPPHAPSPVGGRRGVFASSRHATTGTRGKMAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRL
LLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQ
QHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKG
KLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETGRGVGKNEELRLYHHLFNNYD
PGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDA
NVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRR
HHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGR
FLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFE
GQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLP

--------------------------------------------------------------
>64264_64264_2_PELP1-CHRNE_PELP1_chr17_4579652_ENST00000301396_CHRNE_chr17_4806058_ENST00000293780_length(transcript)=3477nt_BP=1079nt
ACAGGCAGCCTCATCCGCCATCACTCCGGGAACCGAGCACCCCGCTGCCTCGGCGCCCAGGCTGCTCTCTCCGCGCATGCTCCTTCCCAG
CTTGAGCCCGCGAGTCCAGCCTGCCTTCACTCAGTGCGCAAGACCGCAGCCCCCTCCCCACGCCCCCTCCCCAGTAGGCGGCCGTCGCGG
TGTGTTTGCGTCATCGCGCCACGCCACCACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGC
TGGGGTTCCTGGCGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCT
GCAACCTCGAACGGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCT
GCATGGGTCGGTGGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCG
GTTTGAGGGCCTGTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCAT
TCAGCAGGTGTTACAGACCCAGGACCCGCCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCT
GCCTGCACTGTTCCGGGACATCTCCATGAACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGC
ATTGGAAGGAATGAAGGCTTGTATGACCTATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGT
GGATGCCTTGAGCCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAA
GCACACCGAGAGCTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGG
CAGGGGTGTGGGGAAGAACGAGGAACTGCGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGA
GGATACTGTCACCATCAGCCTCAAGGTCACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGAT
TGGAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTG
GCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGT
GACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTT
CCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACAC
AGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGG
GGAGACTGACGTCATCTACTCGCTCATCATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGG
CCTGGTGCTGCTCGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTT
CTTGTTCCTCATTGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCAC
GCTCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCT
CCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGG
CTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGAC
GGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGA
TCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTT
CAGCGTGGGCTCCAGCCTCATCTTCCTCGGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGC
ACCGACTTCAATTTCCCACCCATCTCCAGTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCT
GCTGATCAATCTGCAGTTTGTGAACTTCACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGC
AGGAGGAAAGGGTTCACATAGGCTCTCAGGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTCCCAGCCTT
TCTAAGGCTCAGCCCCACGGGACTCTGGTGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGCCAAACAGGAGACCCCTTT
GCAGGACTTGCACACAGGGAGGCTGTAGCCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTGCTGGAGCGGGTGGGAACCAAACACCTTC
AGTGCTGGTGGCCCTCAGGCCCACAGGTTTAAGGCTGAGGCTGCCCTGACCCTTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCA
CTGCCCATCCCACCCCATGAGGCTCACTCATTGCAGATCCCAGCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAG
TCTACAGTACTGACAGAAAGCAAGGACATGCGGCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCC
ACTACATTGAGGAGGGGTGGGGGGGGAGGGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAG
GGCTCCCTGCTCCCTCCCTCCACCGGGGAAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGGG

>64264_64264_2_PELP1-CHRNE_PELP1_chr17_4579652_ENST00000301396_CHRNE_chr17_4806058_ENST00000293780_length(amino acids)=817AA_BP=339
MLSPRMLLPSLSPRVQPAFTQCARPQPPPHAPSPVGGRRGVFASSRHATTGTRGKMAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRL
LLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQ
QHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKG
KLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETGRGVGKNEELRLYHHLFNNYD
PGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDA
NVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRR
HHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGR
FLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFE
GQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLP

--------------------------------------------------------------
>64264_64264_3_PELP1-CHRNE_PELP1_chr17_4579652_ENST00000572293_CHRNE_chr17_4806058_ENST00000293780_length(transcript)=3465nt_BP=1067nt
ATCCGCCATCACTCCGGGAACCGAGCACCCCGCTGCCTCGGCGCCCAGGCTGCTCTCTCCGCGCATGCTCCTTCCCAGCTTGAGCCCGCG
AGTCCAGCCTGCCTTCACTCAGTGCGCAAGACCGCAGCCCCCTCCCCACGCCCCCTCCCCAGTAGGCGGCCGTCGCGGTGTGTTTGCGTC
ATCGCGCCACGCCACCACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGCTGGGGTTCCTGG
CGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCTGCAACCTCGAAC
GGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCTGCATGGGTCGGT
GGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCGGTTTGAGGGCCT
GTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCATTCAGCAGGTGTT
ACAGACCCAGGACCCGCCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCTGCCTGCACTGTT
CCGGGACATCTCCATGAACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGCATTGGAAGGAAT
GAAGGCTTGTATGACCTATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGTGGATGCCTTGAG
CCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAAGCACACCGAGAG
CTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGGCAGGGGTGTGGG
GAAGAACGAGGAACTGCGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGAGGATACTGTCAC
CATCAGCCTCAAGGTCACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGATTGGAATCGATTG
GCAGGATTACCGACTCAACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTGGCTGCCAGAGAT
TGTGCTGGAAAACAATATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGTGACGTGGCTGCC
TCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTTCCGCTCTCAGAC
GTACAATGCCGAAGAGGTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACACAGAGGCCTATAC
TGAGAACGGCGAGTGGGCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGGGGAGACTGACGT
CATCTACTCGCTCATCATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGGCCTGGTGCTGCT
CGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTTCTTGTTCCTCAT
TGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCACGCTCATTGTCAT
GAATTGCGTCATCGTGCTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCTCCTGGAGCTGCT
GCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGGCTTATTGCTCCG
CGCGGAGGAGCTGATACTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGACGGCTGCCTTCTG
CCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGATCAGGAGGCCAC
CGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTTCAGCGTGGGCTC
CAGCCTCATCTTCCTCGGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGCACCGACTTCAAT
TTCCCACCCATCTCCAGTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCTGCTGATCAATCT
GCAGTTTGTGAACTTCACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGCAGGAGGAAAGGG
TTCACATAGGCTCTCAGGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTCCCAGCCTTTCTAAGGCTCAG
CCCCACGGGACTCTGGTGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGCCAAACAGGAGACCCCTTTGCAGGACTTGCA
CACAGGGAGGCTGTAGCCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTGCTGGAGCGGGTGGGAACCAAACACCTTCAGTGCTGGTGGC
CCTCAGGCCCACAGGTTTAAGGCTGAGGCTGCCCTGACCCTTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCACTGCCCATCCCA
CCCCATGAGGCTCACTCATTGCAGATCCCAGCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAGTCTACAGTACTG
ACAGAAAGCAAGGACATGCGGCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCCACTACATTGAGG
AGGGGTGGGGGGGGAGGGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAGGGCTCCCTGCTC
CCTCCCTCCACCGGGGAAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGGGGTCCCCCCTCCA

>64264_64264_3_PELP1-CHRNE_PELP1_chr17_4579652_ENST00000572293_CHRNE_chr17_4806058_ENST00000293780_length(amino acids)=817AA_BP=339
MLSPRMLLPSLSPRVQPAFTQCARPQPPPHAPSPVGGRRGVFASSRHATTGTRGKMAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRL
LLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQ
QHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKG
KLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETGRGVGKNEELRLYHHLFNNYD
PGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDA
NVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRR
HHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGR
FLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFE
GQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLP

--------------------------------------------------------------
>64264_64264_4_PELP1-CHRNE_PELP1_chr17_4579652_ENST00000574876_CHRNE_chr17_4806058_ENST00000293780_length(transcript)=3269nt_BP=871nt
ACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGCTGGGGTTCCTGGCGGGACCGGGGGTCTC
TCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCTGCAACCTCGAACGGGGTCTGCCGTTGCT
CCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCTGCATGGGTCGGTGGGCGGGGCCCAGAAC
CTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCGGTTTGAGGGCCTGTGTCTGCTGTCCCTG
CTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCATTCAGCAGGTGTTACAGACCCAGGACCCG
CCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCTGCCTGCACTGTTCCGGGACATCTCCATG
AACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGCATTGGAAGGAATGAAGGCTTGTATGACC
TATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGTGGATGCCTTGAGCCCTCAGCTCCAACAG
TTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAAGCACACCGAGAGCTGGGAGCAGGAGCTA
CACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGGCAGGGGTGTGGGGAAGAACGAGGAACTG
CGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGAGGATACTGTCACCATCAGCCTCAAGGTC
ACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGATTGGAATCGATTGGCAGGATTACCGACTC
AACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTGGCTGCCAGAGATTGTGCTGGAAAACAAT
ATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGTGACGTGGCTGCCTCCGGCCATCTACCGC
AGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTTCCGCTCTCAGACGTACAATGCCGAAGAG
GTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACACAGAGGCCTATACTGAGAACGGCGAGTGG
GCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGGGGAGACTGACGTCATCTACTCGCTCATC
ATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGGCCTGGTGCTGCTCGCCTACTTCCTGCCG
GCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTTCTTGTTCCTCATTGCCCAGAAAATCCCA
GAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCACGCTCATTGTCATGAATTGCGTCATCGTG
CTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCTCCTGGAGCTGCTGCCGCGCCTCCTGGGC
TCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGGCTTATTGCTCCGCGCGGAGGAGCTGATA
CTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGACGGCTGCCTTCTGCCAGAGCCTGGGCGCC
GCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGATCAGGAGGCCACCGGCGAGGAAGTGTCC
GACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTTCAGCGTGGGCTCCAGCCTCATCTTCCTC
GGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGCACCGACTTCAATTTCCCACCCATCTCCA
GTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCTGCTGATCAATCTGCAGTTTGTGAACTTC
ACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGCAGGAGGAAAGGGTTCACATAGGCTCTCA
GGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTCCCAGCCTTTCTAAGGCTCAGCCCCACGGGACTCTGG
TGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGCCAAACAGGAGACCCCTTTGCAGGACTTGCACACAGGGAGGCTGTAG
CCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTGCTGGAGCGGGTGGGAACCAAACACCTTCAGTGCTGGTGGCCCTCAGGCCCACAGGT
TTAAGGCTGAGGCTGCCCTGACCCTTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCACTGCCCATCCCACCCCATGAGGCTCACT
CATTGCAGATCCCAGCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAGTCTACAGTACTGACAGAAAGCAAGGACA
TGCGGCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCCACTACATTGAGGAGGGGTGGGGGGGGAG
GGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAGGGCTCCCTGCTCCCTCCCTCCACCGGGG
AAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGGGGTCCCCCCTCCATTCCCTGGAGTTTGGG

>64264_64264_4_PELP1-CHRNE_PELP1_chr17_4579652_ENST00000574876_CHRNE_chr17_4806058_ENST00000293780_length(amino acids)=762AA_BP=284
MAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGA
LVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGL
LTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLAS
LHTLLGALYEGAETGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDD
FGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFA
VDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQ
KCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPE
APRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PELP1-CHRNE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PELP1-CHRNE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PELP1-CHRNE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource