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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PEPD-GRAMD1A (FusionGDB2 ID:64286)

Fusion Gene Summary for PEPD-GRAMD1A

check button Fusion gene summary
Fusion gene informationFusion gene name: PEPD-GRAMD1A
Fusion gene ID: 64286
HgeneTgene
Gene symbol

PEPD

GRAMD1A

Gene ID

5184

57655

Gene namepeptidase DGRAM domain containing 1A
SynonymsPROLIDASEKIAA1533
Cytomap

19q13.11

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionxaa-Pro dipeptidaseX-Pro dipeptidaseaminoacyl-L-proline hydrolaseimidodipeptidaseproline dipeptidasetesticular tissue protein Li 138protein Aster-AGRAM domain-containing protein 1A
Modification date2020031320200313
UniProtAcc.

Q96CP6

Ensembl transtripts involved in fusion geneENST00000244137, ENST00000436370, 
ENST00000397032, ENST00000591968, 
ENST00000598073, ENST00000411896, 
ENST00000424536, ENST00000504615, 
ENST00000317991, ENST00000599564, 
Fusion gene scores* DoF score11 X 8 X 8=7045 X 5 X 5=125
# samples 125
** MAII scorelog2(12/704*10)=-2.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PEPD [Title/Abstract] AND GRAMD1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPEPD(33953901)-GRAMD1A(35500023), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PEPD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRAMD1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A3CC-06APEPDchr19

33953901

-GRAMD1Achr19

35500023

+


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Fusion Gene ORF analysis for PEPD-GRAMD1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000244137ENST00000598073PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
5CDS-3UTRENST00000436370ENST00000598073PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
5CDS-5UTRENST00000244137ENST00000411896PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
5CDS-5UTRENST00000244137ENST00000424536PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
5CDS-5UTRENST00000244137ENST00000504615PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
5CDS-5UTRENST00000436370ENST00000411896PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
5CDS-5UTRENST00000436370ENST00000424536PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
5CDS-5UTRENST00000436370ENST00000504615PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
In-frameENST00000244137ENST00000317991PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
In-frameENST00000244137ENST00000599564PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
In-frameENST00000436370ENST00000317991PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
In-frameENST00000436370ENST00000599564PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-3CDSENST00000397032ENST00000317991PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-3CDSENST00000397032ENST00000599564PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-3CDSENST00000591968ENST00000317991PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-3CDSENST00000591968ENST00000599564PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-3UTRENST00000397032ENST00000598073PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-3UTRENST00000591968ENST00000598073PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-5UTRENST00000397032ENST00000411896PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-5UTRENST00000397032ENST00000424536PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-5UTRENST00000397032ENST00000504615PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-5UTRENST00000591968ENST00000411896PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-5UTRENST00000591968ENST00000424536PEPDchr19

33953901

-GRAMD1Achr19

35500023

+
intron-5UTRENST00000591968ENST00000504615PEPDchr19

33953901

-GRAMD1Achr19

35500023

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000244137PEPDchr1933953901-ENST00000599564GRAMD1Achr1935500023+3190705342859941
ENST00000244137PEPDchr1933953901-ENST00000317991GRAMD1Achr1935500023+3200705342871945
ENST00000436370PEPDchr1933953901-ENST00000599564GRAMD1Achr1935500023+2992507282661877
ENST00000436370PEPDchr1933953901-ENST00000317991GRAMD1Achr1935500023+3002507282673881

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000244137ENST00000599564PEPDchr1933953901-GRAMD1Achr1935500023+0.0046996410.9953003
ENST00000244137ENST00000317991PEPDchr1933953901-GRAMD1Achr1935500023+0.00464640.9953536
ENST00000436370ENST00000599564PEPDchr1933953901-GRAMD1Achr1935500023+0.0093822810.9906177
ENST00000436370ENST00000317991PEPDchr1933953901-GRAMD1Achr1935500023+0.0087473640.9912526

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Fusion Genomic Features for PEPD-GRAMD1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PEPDchr1933953900-GRAMD1Achr1935500022+5.44E-060.9999945
PEPDchr1933953900-GRAMD1Achr1935500022+5.44E-060.9999945

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PEPD-GRAMD1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:33953901/chr19:35500023)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRAMD1A

Q96CP6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRAMD1Achr19:33953901chr19:35500023ENST00000317991020367_5382725.0DomainVASt
TgeneGRAMD1Achr19:33953901chr19:35500023ENST0000031799102091_1582725.0DomainGRAM
TgeneGRAMD1Achr19:33953901chr19:35500023ENST00000411896018367_5382714.0DomainVASt
TgeneGRAMD1Achr19:33953901chr19:35500023ENST0000041189601891_1582714.0DomainGRAM
TgeneGRAMD1Achr19:33953901chr19:35500023ENST00000317991020610_6302725.0TransmembraneHelical
TgeneGRAMD1Achr19:33953901chr19:35500023ENST00000411896018610_6302714.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PEPD-GRAMD1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64286_64286_1_PEPD-GRAMD1A_PEPD_chr19_33953901_ENST00000244137_GRAMD1A_chr19_35500023_ENST00000317991_length(transcript)=3200nt_BP=705nt
GCCGCACTTCACGTGACGCCGGTGCCGGGCGAACATGGCGGCGGCCACCGGACCCTCGTTTTGGCTGGGGAATGAAACCCTGAAGGTGCC
GCTGGCGCTCTTTGCCTTGAACCGGCAGCGCCTGTGTGAGCGGCTGCGGAAGAACCCTGCTGTGCAGGCCGGCTCCATCGTGGTCCTGCA
GGGCGGGGAGGAGACTCAGCGCTACTGCACCGACACCGGGGTCCTCTTCCGCCAGGAGTCCTTCTTTCACTGGGCGTTCGGTGTCACTGA
GCCAGGCTGCTATGGTGTCATCGATGTTGACACTGGGAAGTCGACCCTGTTTGTGCCCAGGCTTCCTGCCAGCCATGCCACCTGGATGGG
AAAGATCCATTCCAAGGAGCACTTCAAGGAGAAGTATGCCGTGGACGACGTCCAGTACGTAGATGAGATTGCCAGCGTCCTGACGTCACA
GAAGCCCTCTGTCCTCCTCACTTTGCGTGGCGTCAACACGGACAGCGGCAGTGTCTGCAGGGAGGCCTCCTTTGACGGCATCAGCAAGTT
CGAAGTCAACAATACCATTCTTCACCCAGAGATCGTTGAGTGCCGAGTGTTTAAGACGGATATGGAGCTGGAGGTTCTGCGCTATACCAA
TAAAATCTCCAGCGAGGCCCACCGTGAGGTAATGAAGGCTGTAAAAGTGGGAATGAAAGAATATGAGTTGGAAAGCACCACACCCCACTC
TGGCCGGAGCACGCCAAGCAGCTCCCCATCGCTCCGGAAACGGCTGCAGCTCCTGCCCCCAAGCCGGCCCCCACCTGAGCCAGAACCAGG
CACCATGGTGGAGAAGGGATCAGATAGCTCCTCAGAGAAGGGTGGGGTGCCTGGGACCCCCAGCACCCAGAGCCTAGGCAGCCGGAACTT
CATCCGCAACAGCAAGAAGATGCAGAGCTGGTACAGTATGCTGAGCCCCACTTATAAGCAGCGTAATGAGGACTTCCGGAAACTGTTCAG
CAAACTCCCCGAAGCAGAACGCCTCATTGTGGATTACTCCTGCGCCCTGCAGCGTGAGATCCTGCTCCAGGGCCGCCTCTACCTCTCTGA
GAACTGGATCTGCTTCTACAGCAACATCTTCCGCTGGGAGACCACGATCTCCATCCAGCTGAAGGAAGTGACATGTCTGAAGAAGGAAAA
GACGGCCAAGCTGATCCCCAACGCCATCCAGATCTGCACGGAGAGCGAGAAGCATTTCTTCACTTCCTTTGGGGCCCGTGACCGCTGCTT
CCTCCTCATCTTCCGCCTCTGGCAGAATGCACTGCTTGAAAAGACGCTGAGTCCCCGCGAGCTCTGGCACCTGGTGCATCAGTGCTACGG
CTCAGAGCTGGGCCTCACCAGTGAGGATGAGGACTATGTCTCCCCCTTGCAGCTGAACGGTCTGGGGACCCCCAAGGAAGTGGGAGATGT
GATCGCCCTGAGCGACATCACCTCCTCGGGGGCAGCTGACCGCAGCCAGGAGCCAAGCCCAGTGGGTTCGCGCCGTGGCCATGTCACGCC
CAACCTTTCCCGAGCCAGCAGCGACGCAGACCATGGGGCAGAGGAGGACAAGGAGGAGCAGGTAGACAGCCAGCCAGACGCCTCCTCCAG
CCAGACAGTGACCCCGGTGGCTGAACCCCCGAGCACAGAGCCCACCCAGCCTGACGGGCCCACCACCCTGGGCCCCTTGGATCTGCTGCC
CAGTGAGGAGCTATTGACAGACACAAGTAACTCCTCTTCATCCACTGGGGAGGAAGCGGACTTGGCTGCCCTGCTTCCCGACCTCTCCGG
CCGCCTCCTCATCAACTCTGTCTTCCATGTGGGCGCTGAGCGGCTCCAGCAGATGCTCTTCTCGGACTCGCCCTTCCTCCAGGGCTTCCT
ACAGCAGTGCAAGTTCACAGACGTGACGCTGAGCCCCTGGAGTGGGGACAGCAAGTGCCACCAGCGCCGGGTGCTGACGTACACCATCCC
CATCAGCAACCCACTGGGCCCCAAGAGCGCCTCCGTGGTGGAGACACAGACGCTGTTCCGGCGCGGCCCCCAGGCCGGCGGGTGTGTGGT
GGACTCCGAGGTGCTGACGCAGGGCATCCCCTACCAGGACTACTTCTACACTGCCCACCGCTACTGCATCCTGGGTCTGGCCCGGAACAA
GGCGCGGCTCCGAGTGTCTTCTGAGATCCGCTACCGAAAGCAGCCGTGGAGCCTGGTGAAGTCGCTCATTGAGAAGAACTCGTGGAGCGG
CATTGAAGACTATTTCCACCATCTGGAGCGAGAGCTCGCCAAGGCTGAGAAGCTGTCTCTGGAGGAAGGCGGGAAGGATGCCCGGGGCTT
GCTATCCGGCCTGCGGCGGCGGAAGCGGCCCCTGAGCTGGCGGGCTCACGGGGACGGGCCCCAGCACCCAGATCCTGACCCCTGTGCCCG
GGCCGGCATTCACACCTCGGGCTCCCTCAGCTCCCGCTTCTCCGAACCATCTGTGGACCAGGGCCCCGGGGCAGGCATCCCCAGTGCCCT
GGTTCTCATCAGCATTGTGATCTGTGTGAGCCTTATCATCCTCATCGCCCTCAACGTCCTGCTCTTCTACCGCCTCTGGTCCCTGGAAAG
GACAGCCCACACCTTTGAGTCCTGGCACAGCCTGGCCCTGGCCAAGGGCAAGTTCCCCCAGACGGCCACAGAGTGGGCCGAGATCCTGGC
GCTGCAGAAGCAATTCCACAGCGTGGAGGTGCACAAGTGGAGGCAGATCCTGCGGGCCTCCGTGGAGCTCCTGGATGAGATGAAGTTCTC
GCTGGAGAAGCTGCACCAAGGCATCACAGTCTCAGACCCTCCCTTTGACACCCAGCCCCGGCCCGATGACAGCTTTTCCTGAGGACCCCG
GCCACGCAGCTGTTCCCCCACATGGACAGATGGACACACAGAGCCTCGGCGGCCACTGCTGGCACGGTGTGAGCGCCAGGCATCTCCCAC
CCGCCCCTCCCGACGGCCCAACCAGGGGCTGTGCAGACGTGGGGACCACGGAACCGAGATGCACTTTAGACCAGGGAGCTGGCCCGGCCT
CTGGCAGGCCCCCCACTAACTTATTTTGCCCGGCTGAGGTTGTGGGGGGCGCCTCCTGGGGTGCACGATTCCCTCAGCTCTGGGTTTAAT

>64286_64286_1_PEPD-GRAMD1A_PEPD_chr19_33953901_ENST00000244137_GRAMD1A_chr19_35500023_ENST00000317991_length(amino acids)=945AA_BP=223
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDT
GKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEI
VECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSS
EKGGVPGTPSTQSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFR
WETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDED
YVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPS
TEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLS
PWSGDSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRY
RKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSS
RFSEPSVDQGPGAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKQFHSVEVH

--------------------------------------------------------------
>64286_64286_2_PEPD-GRAMD1A_PEPD_chr19_33953901_ENST00000244137_GRAMD1A_chr19_35500023_ENST00000599564_length(transcript)=3190nt_BP=705nt
GCCGCACTTCACGTGACGCCGGTGCCGGGCGAACATGGCGGCGGCCACCGGACCCTCGTTTTGGCTGGGGAATGAAACCCTGAAGGTGCC
GCTGGCGCTCTTTGCCTTGAACCGGCAGCGCCTGTGTGAGCGGCTGCGGAAGAACCCTGCTGTGCAGGCCGGCTCCATCGTGGTCCTGCA
GGGCGGGGAGGAGACTCAGCGCTACTGCACCGACACCGGGGTCCTCTTCCGCCAGGAGTCCTTCTTTCACTGGGCGTTCGGTGTCACTGA
GCCAGGCTGCTATGGTGTCATCGATGTTGACACTGGGAAGTCGACCCTGTTTGTGCCCAGGCTTCCTGCCAGCCATGCCACCTGGATGGG
AAAGATCCATTCCAAGGAGCACTTCAAGGAGAAGTATGCCGTGGACGACGTCCAGTACGTAGATGAGATTGCCAGCGTCCTGACGTCACA
GAAGCCCTCTGTCCTCCTCACTTTGCGTGGCGTCAACACGGACAGCGGCAGTGTCTGCAGGGAGGCCTCCTTTGACGGCATCAGCAAGTT
CGAAGTCAACAATACCATTCTTCACCCAGAGATCGTTGAGTGCCGAGTGTTTAAGACGGATATGGAGCTGGAGGTTCTGCGCTATACCAA
TAAAATCTCCAGCGAGGCCCACCGTGAGGTAATGAAGGCTGTAAAAGTGGGAATGAAAGAATATGAGTTGGAAAGCACCACACCCCACTC
TGGCCGGAGCACGCCAAGCAGCTCCCCATCGCTCCGGAAACGGCTGCAGCTCCTGCCCCCAAGCCGGCCCCCACCTGAGCCAGAACCAGG
CACCATGGTGGAGAAGGGATCAGATAGCTCCTCAGAGAAGGGTGGGGTGCCTGGGACCCCCAGCACCCAGAGCCTAGGCAGCCGGAACTT
CATCCGCAACAGCAAGAAGATGCAGAGCTGGTACAGTATGCTGAGCCCCACTTATAAGCAGCGTAATGAGGACTTCCGGAAACTGTTCAG
CAAACTCCCCGAAGCAGAACGCCTCATTGTGGATTACTCCTGCGCCCTGCAGCGTGAGATCCTGCTCCAGGGCCGCCTCTACCTCTCTGA
GAACTGGATCTGCTTCTACAGCAACATCTTCCGCTGGGAGACCACGATCTCCATCCAGCTGAAGGAAGTGACATGTCTGAAGAAGGAAAA
GACGGCCAAGCTGATCCCCAACGCCATCCAGATCTGCACGGAGAGCGAGAAGCATTTCTTCACTTCCTTTGGGGCCCGTGACCGCTGCTT
CCTCCTCATCTTCCGCCTCTGGCAGAATGCACTGCTTGAAAAGACGCTGAGTCCCCGCGAGCTCTGGCACCTGGTGCATCAGTGCTACGG
CTCAGAGCTGGGCCTCACCAGTGAGGATGAGGACTATGTCTCCCCCTTGCAGCTGAACGGTCTGGGGACCCCCAAGGAAGTGGGAGATGT
GATCGCCCTGAGCGACATCACCTCCTCGGGGGCAGCTGACCGCAGCCAGGAGCCAAGCCCAGTGGGTTCGCGCCGTGGCCATGTCACGCC
CAACCTTTCCCGAGCCAGCAGCGACGCAGACCATGGGGCAGAGGAGGACAAGGAGGAGCAGGTAGACAGCCAGCCAGACGCCTCCTCCAG
CCAGACAGTGACCCCGGTGGCTGAACCCCCGAGCACAGAGCCCACCCAGCCTGACGGGCCCACCACCCTGGGCCCCTTGGATCTGCTGCC
CAGTGAGGAGCTATTGACAGACACAAGTAACTCCTCTTCATCCACTGGGGAGGAAGCGGACTTGGCTGCCCTGCTTCCCGACCTCTCCGG
CCGCCTCCTCATCAACTCTGTCTTCCATGTGGGCGCTGAGCGGCTCCAGCAGATGCTCTTCTCGGACTCGCCCTTCCTCCAGGGCTTCCT
ACAGCAGTGCAAGTTCACAGACGTGACGCTGAGCCCCTGGAGTGGGGACAGCAAGTGCCACCAGCGCCGGGTGCTGACGTACACCATCCC
CATCAGCAACCCACTGGGCCCCAAGAGCGCCTCCGTGGTGGAGACACAGACGCTGTTCCGGCGCGGCCCCCAGGCCGGCGGGTGTGTGGT
GGACTCCGAGGTGCTGACGCAGGGCATCCCCTACCAGGACTACTTCTACACTGCCCACCGCTACTGCATCCTGGGTCTGGCCCGGAACAA
GGCGCGGCTCCGAGTGTCTTCTGAGATCCGCTACCGAAAGCAGCCGTGGAGCCTGGTGAAGTCGCTCATTGAGAAGAACTCGTGGAGCGG
CATTGAAGACTATTTCCACCATCTGGAGCGAGAGCTCGCCAAGGCTGAGAAGCTGTCTCTGGAGGAAGGCGGGAAGGATGCCCGGGGCTT
GCTATCCGGCCTGCGGCGGCGGAAGCGGCCCCTGAGCTGGCGGGCTCACGGGGACGGGCCCCAGCACCCAGATCCTGACCCCTGTGCCCG
GGCCGGCATTCACACCTCGGGCTCCCTCAGCTCCCGCTTCTCCGAACCATCTGTGGACCAGGGCCCCGGGGCAGGCATCCCCAGTGCCCT
GGTTCTCATCAGCATTGTCCTTATCATCCTCATCGCCCTCAACGTCCTGCTCTTCTACCGCCTCTGGTCCCTGGAAAGGACAGCCCACAC
CTTTGAGTCCTGGCACAGCCTGGCCCTGGCCAAGGGCAAGTTCCCCCAGACGGCCACAGAGTGGGCCGAGATCCTGGCGCTGCAGAAGCA
ATTCCACAGCGTGGAGGTGCACAAGTGGAGGCAGATCCTGCGGGCCTCCGTGGAGCTCCTGGATGAGATGAAGTTCTCGCTGGAGAAGCT
GCACCAAGGCATCACAGTCTCAGACCCTCCCTTTGACACCCAGCCCCGGCCCGATGACAGCTTTTCCTGAGGACCCCGGCCACGCAGCTG
TTCCCCCACATGGACAGATGGACACACAGAGCCTCGGCGGCCACTGCTGGCACGGTGTGAGCGCCAGGCATCTCCCACCCGCCCCTCCCG
ACGGCCCAACCAGGGGCTGTGCAGACGTGGGGACCACGGAACCGAGATGCACTTTAGACCAGGGAGCTGGCCCGGCCTCTGGCAGGCCCC
CCACTAACTTATTTTGCCCGGCTGAGGTTGTGGGGGGCGCCTCCTGGGGTGCACGATTCCCTCAGCTCTGGGTTTAATGTATTATATTTA

>64286_64286_2_PEPD-GRAMD1A_PEPD_chr19_33953901_ENST00000244137_GRAMD1A_chr19_35500023_ENST00000599564_length(amino acids)=941AA_BP=223
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDT
GKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEI
VECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSS
EKGGVPGTPSTQSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFR
WETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDED
YVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPS
TEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLS
PWSGDSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRY
RKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSS
RFSEPSVDQGPGAGIPSALVLISIVLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKQFHSVEVHKWRQ

--------------------------------------------------------------
>64286_64286_3_PEPD-GRAMD1A_PEPD_chr19_33953901_ENST00000436370_GRAMD1A_chr19_35500023_ENST00000317991_length(transcript)=3002nt_BP=507nt
CTTCACGTGACGCCGGTGCCGGGCGAACATGGCGGCGGCCACCGGACCCTCGTTTTGGCTGGGGAATGAAACCCTGAAGGTGCCGCTGGC
GCTCTTTGCCTTGAACCGGCAGCGCCTGTGTGAGCGGCTGCGGAAGAACCCTGCTGTGCAGGCCGGCTCCATCGTGGTCCTGCAGGGCGG
GGAGGAGACTCAGCGCTACTGCACCGACACCGGGGTCCTCTTCCGCCAGATTGCCAGCGTCCTGACGTCACAGAAGCCCTCTGTCCTCCT
CACTTTGCGTGGCGTCAACACGGACAGCGGCAGTGTCTGCAGGGAGGCCTCCTTTGACGGCATCAGCAAGTTCGAAGTCAACAATACCAT
TCTTCACCCAGAGATCGTTGAGTGCCGAGTGTTTAAGACGGATATGGAGCTGGAGGTTCTGCGCTATACCAATAAAATCTCCAGCGAGGC
CCACCGTGAGGTAATGAAGGCTGTAAAAGTGGGAATGAAAGAATATGAGTTGGAAAGCACCACACCCCACTCTGGCCGGAGCACGCCAAG
CAGCTCCCCATCGCTCCGGAAACGGCTGCAGCTCCTGCCCCCAAGCCGGCCCCCACCTGAGCCAGAACCAGGCACCATGGTGGAGAAGGG
ATCAGATAGCTCCTCAGAGAAGGGTGGGGTGCCTGGGACCCCCAGCACCCAGAGCCTAGGCAGCCGGAACTTCATCCGCAACAGCAAGAA
GATGCAGAGCTGGTACAGTATGCTGAGCCCCACTTATAAGCAGCGTAATGAGGACTTCCGGAAACTGTTCAGCAAACTCCCCGAAGCAGA
ACGCCTCATTGTGGATTACTCCTGCGCCCTGCAGCGTGAGATCCTGCTCCAGGGCCGCCTCTACCTCTCTGAGAACTGGATCTGCTTCTA
CAGCAACATCTTCCGCTGGGAGACCACGATCTCCATCCAGCTGAAGGAAGTGACATGTCTGAAGAAGGAAAAGACGGCCAAGCTGATCCC
CAACGCCATCCAGATCTGCACGGAGAGCGAGAAGCATTTCTTCACTTCCTTTGGGGCCCGTGACCGCTGCTTCCTCCTCATCTTCCGCCT
CTGGCAGAATGCACTGCTTGAAAAGACGCTGAGTCCCCGCGAGCTCTGGCACCTGGTGCATCAGTGCTACGGCTCAGAGCTGGGCCTCAC
CAGTGAGGATGAGGACTATGTCTCCCCCTTGCAGCTGAACGGTCTGGGGACCCCCAAGGAAGTGGGAGATGTGATCGCCCTGAGCGACAT
CACCTCCTCGGGGGCAGCTGACCGCAGCCAGGAGCCAAGCCCAGTGGGTTCGCGCCGTGGCCATGTCACGCCCAACCTTTCCCGAGCCAG
CAGCGACGCAGACCATGGGGCAGAGGAGGACAAGGAGGAGCAGGTAGACAGCCAGCCAGACGCCTCCTCCAGCCAGACAGTGACCCCGGT
GGCTGAACCCCCGAGCACAGAGCCCACCCAGCCTGACGGGCCCACCACCCTGGGCCCCTTGGATCTGCTGCCCAGTGAGGAGCTATTGAC
AGACACAAGTAACTCCTCTTCATCCACTGGGGAGGAAGCGGACTTGGCTGCCCTGCTTCCCGACCTCTCCGGCCGCCTCCTCATCAACTC
TGTCTTCCATGTGGGCGCTGAGCGGCTCCAGCAGATGCTCTTCTCGGACTCGCCCTTCCTCCAGGGCTTCCTACAGCAGTGCAAGTTCAC
AGACGTGACGCTGAGCCCCTGGAGTGGGGACAGCAAGTGCCACCAGCGCCGGGTGCTGACGTACACCATCCCCATCAGCAACCCACTGGG
CCCCAAGAGCGCCTCCGTGGTGGAGACACAGACGCTGTTCCGGCGCGGCCCCCAGGCCGGCGGGTGTGTGGTGGACTCCGAGGTGCTGAC
GCAGGGCATCCCCTACCAGGACTACTTCTACACTGCCCACCGCTACTGCATCCTGGGTCTGGCCCGGAACAAGGCGCGGCTCCGAGTGTC
TTCTGAGATCCGCTACCGAAAGCAGCCGTGGAGCCTGGTGAAGTCGCTCATTGAGAAGAACTCGTGGAGCGGCATTGAAGACTATTTCCA
CCATCTGGAGCGAGAGCTCGCCAAGGCTGAGAAGCTGTCTCTGGAGGAAGGCGGGAAGGATGCCCGGGGCTTGCTATCCGGCCTGCGGCG
GCGGAAGCGGCCCCTGAGCTGGCGGGCTCACGGGGACGGGCCCCAGCACCCAGATCCTGACCCCTGTGCCCGGGCCGGCATTCACACCTC
GGGCTCCCTCAGCTCCCGCTTCTCCGAACCATCTGTGGACCAGGGCCCCGGGGCAGGCATCCCCAGTGCCCTGGTTCTCATCAGCATTGT
GATCTGTGTGAGCCTTATCATCCTCATCGCCCTCAACGTCCTGCTCTTCTACCGCCTCTGGTCCCTGGAAAGGACAGCCCACACCTTTGA
GTCCTGGCACAGCCTGGCCCTGGCCAAGGGCAAGTTCCCCCAGACGGCCACAGAGTGGGCCGAGATCCTGGCGCTGCAGAAGCAATTCCA
CAGCGTGGAGGTGCACAAGTGGAGGCAGATCCTGCGGGCCTCCGTGGAGCTCCTGGATGAGATGAAGTTCTCGCTGGAGAAGCTGCACCA
AGGCATCACAGTCTCAGACCCTCCCTTTGACACCCAGCCCCGGCCCGATGACAGCTTTTCCTGAGGACCCCGGCCACGCAGCTGTTCCCC
CACATGGACAGATGGACACACAGAGCCTCGGCGGCCACTGCTGGCACGGTGTGAGCGCCAGGCATCTCCCACCCGCCCCTCCCGACGGCC
CAACCAGGGGCTGTGCAGACGTGGGGACCACGGAACCGAGATGCACTTTAGACCAGGGAGCTGGCCCGGCCTCTGGCAGGCCCCCCACTA
ACTTATTTTGCCCGGCTGAGGTTGTGGGGGGCGCCTCCTGGGGTGCACGATTCCCTCAGCTCTGGGTTTAATGTATTATATTTATTTGGG

>64286_64286_3_PEPD-GRAMD1A_PEPD_chr19_33953901_ENST00000436370_GRAMD1A_chr19_35500023_ENST00000317991_length(amino acids)=881AA_BP=159
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQIASVLTSQKPSVLLTLRGVNTDS
GSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESTTPHSGRSTPSSSPSLRKRL
QLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCA
LQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKT
LSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEE
DKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGAERL
QQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYF
YTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARGLLSGLRRRKRPLSWRA
HGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAK

--------------------------------------------------------------
>64286_64286_4_PEPD-GRAMD1A_PEPD_chr19_33953901_ENST00000436370_GRAMD1A_chr19_35500023_ENST00000599564_length(transcript)=2992nt_BP=507nt
CTTCACGTGACGCCGGTGCCGGGCGAACATGGCGGCGGCCACCGGACCCTCGTTTTGGCTGGGGAATGAAACCCTGAAGGTGCCGCTGGC
GCTCTTTGCCTTGAACCGGCAGCGCCTGTGTGAGCGGCTGCGGAAGAACCCTGCTGTGCAGGCCGGCTCCATCGTGGTCCTGCAGGGCGG
GGAGGAGACTCAGCGCTACTGCACCGACACCGGGGTCCTCTTCCGCCAGATTGCCAGCGTCCTGACGTCACAGAAGCCCTCTGTCCTCCT
CACTTTGCGTGGCGTCAACACGGACAGCGGCAGTGTCTGCAGGGAGGCCTCCTTTGACGGCATCAGCAAGTTCGAAGTCAACAATACCAT
TCTTCACCCAGAGATCGTTGAGTGCCGAGTGTTTAAGACGGATATGGAGCTGGAGGTTCTGCGCTATACCAATAAAATCTCCAGCGAGGC
CCACCGTGAGGTAATGAAGGCTGTAAAAGTGGGAATGAAAGAATATGAGTTGGAAAGCACCACACCCCACTCTGGCCGGAGCACGCCAAG
CAGCTCCCCATCGCTCCGGAAACGGCTGCAGCTCCTGCCCCCAAGCCGGCCCCCACCTGAGCCAGAACCAGGCACCATGGTGGAGAAGGG
ATCAGATAGCTCCTCAGAGAAGGGTGGGGTGCCTGGGACCCCCAGCACCCAGAGCCTAGGCAGCCGGAACTTCATCCGCAACAGCAAGAA
GATGCAGAGCTGGTACAGTATGCTGAGCCCCACTTATAAGCAGCGTAATGAGGACTTCCGGAAACTGTTCAGCAAACTCCCCGAAGCAGA
ACGCCTCATTGTGGATTACTCCTGCGCCCTGCAGCGTGAGATCCTGCTCCAGGGCCGCCTCTACCTCTCTGAGAACTGGATCTGCTTCTA
CAGCAACATCTTCCGCTGGGAGACCACGATCTCCATCCAGCTGAAGGAAGTGACATGTCTGAAGAAGGAAAAGACGGCCAAGCTGATCCC
CAACGCCATCCAGATCTGCACGGAGAGCGAGAAGCATTTCTTCACTTCCTTTGGGGCCCGTGACCGCTGCTTCCTCCTCATCTTCCGCCT
CTGGCAGAATGCACTGCTTGAAAAGACGCTGAGTCCCCGCGAGCTCTGGCACCTGGTGCATCAGTGCTACGGCTCAGAGCTGGGCCTCAC
CAGTGAGGATGAGGACTATGTCTCCCCCTTGCAGCTGAACGGTCTGGGGACCCCCAAGGAAGTGGGAGATGTGATCGCCCTGAGCGACAT
CACCTCCTCGGGGGCAGCTGACCGCAGCCAGGAGCCAAGCCCAGTGGGTTCGCGCCGTGGCCATGTCACGCCCAACCTTTCCCGAGCCAG
CAGCGACGCAGACCATGGGGCAGAGGAGGACAAGGAGGAGCAGGTAGACAGCCAGCCAGACGCCTCCTCCAGCCAGACAGTGACCCCGGT
GGCTGAACCCCCGAGCACAGAGCCCACCCAGCCTGACGGGCCCACCACCCTGGGCCCCTTGGATCTGCTGCCCAGTGAGGAGCTATTGAC
AGACACAAGTAACTCCTCTTCATCCACTGGGGAGGAAGCGGACTTGGCTGCCCTGCTTCCCGACCTCTCCGGCCGCCTCCTCATCAACTC
TGTCTTCCATGTGGGCGCTGAGCGGCTCCAGCAGATGCTCTTCTCGGACTCGCCCTTCCTCCAGGGCTTCCTACAGCAGTGCAAGTTCAC
AGACGTGACGCTGAGCCCCTGGAGTGGGGACAGCAAGTGCCACCAGCGCCGGGTGCTGACGTACACCATCCCCATCAGCAACCCACTGGG
CCCCAAGAGCGCCTCCGTGGTGGAGACACAGACGCTGTTCCGGCGCGGCCCCCAGGCCGGCGGGTGTGTGGTGGACTCCGAGGTGCTGAC
GCAGGGCATCCCCTACCAGGACTACTTCTACACTGCCCACCGCTACTGCATCCTGGGTCTGGCCCGGAACAAGGCGCGGCTCCGAGTGTC
TTCTGAGATCCGCTACCGAAAGCAGCCGTGGAGCCTGGTGAAGTCGCTCATTGAGAAGAACTCGTGGAGCGGCATTGAAGACTATTTCCA
CCATCTGGAGCGAGAGCTCGCCAAGGCTGAGAAGCTGTCTCTGGAGGAAGGCGGGAAGGATGCCCGGGGCTTGCTATCCGGCCTGCGGCG
GCGGAAGCGGCCCCTGAGCTGGCGGGCTCACGGGGACGGGCCCCAGCACCCAGATCCTGACCCCTGTGCCCGGGCCGGCATTCACACCTC
GGGCTCCCTCAGCTCCCGCTTCTCCGAACCATCTGTGGACCAGGGCCCCGGGGCAGGCATCCCCAGTGCCCTGGTTCTCATCAGCATTGT
CCTTATCATCCTCATCGCCCTCAACGTCCTGCTCTTCTACCGCCTCTGGTCCCTGGAAAGGACAGCCCACACCTTTGAGTCCTGGCACAG
CCTGGCCCTGGCCAAGGGCAAGTTCCCCCAGACGGCCACAGAGTGGGCCGAGATCCTGGCGCTGCAGAAGCAATTCCACAGCGTGGAGGT
GCACAAGTGGAGGCAGATCCTGCGGGCCTCCGTGGAGCTCCTGGATGAGATGAAGTTCTCGCTGGAGAAGCTGCACCAAGGCATCACAGT
CTCAGACCCTCCCTTTGACACCCAGCCCCGGCCCGATGACAGCTTTTCCTGAGGACCCCGGCCACGCAGCTGTTCCCCCACATGGACAGA
TGGACACACAGAGCCTCGGCGGCCACTGCTGGCACGGTGTGAGCGCCAGGCATCTCCCACCCGCCCCTCCCGACGGCCCAACCAGGGGCT
GTGCAGACGTGGGGACCACGGAACCGAGATGCACTTTAGACCAGGGAGCTGGCCCGGCCTCTGGCAGGCCCCCCACTAACTTATTTTGCC
CGGCTGAGGTTGTGGGGGGCGCCTCCTGGGGTGCACGATTCCCTCAGCTCTGGGTTTAATGTATTATATTTATTTGGGGCCGACAGTGCC

>64286_64286_4_PEPD-GRAMD1A_PEPD_chr19_33953901_ENST00000436370_GRAMD1A_chr19_35500023_ENST00000599564_length(amino acids)=877AA_BP=159
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQIASVLTSQKPSVLLTLRGVNTDS
GSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESTTPHSGRSTPSSSPSLRKRL
QLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCA
LQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKT
LSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEE
DKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGAERL
QQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYF
YTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARGLLSGLRRRKRPLSWRA
HGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PEPD-GRAMD1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PEPD-GRAMD1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PEPD-GRAMD1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource