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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PEX7-TCF21 (FusionGDB2 ID:64391)

Fusion Gene Summary for PEX7-TCF21

check button Fusion gene summary
Fusion gene informationFusion gene name: PEX7-TCF21
Fusion gene ID: 64391
HgeneTgene
Gene symbol

PEX7

TCF21

Gene ID

5191

6943

Gene nameperoxisomal biogenesis factor 7transcription factor 21
SynonymsPBD9B|PTS2R|RCDP1|RDPOD1|bHLHa23
Cytomap

6q23.3

6q23.2

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal biogenesis factor 7PTS2 receptorperoxin-7peroxisomal PTS2 receptorperoxisomal targeting signal 2 receptorperoxisome targeting signal 2 receptortranscription factor 21capsulinclass A basic helix-loop-helix protein 23epicardinpod-1podocyte-expressed 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000318471, ENST00000367756, 
ENST00000541292, 
ENST00000237316, 
ENST00000367882, 
Fusion gene scores* DoF score5 X 5 X 4=1001 X 1 X 1=1
# samples 51
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PEX7 [Title/Abstract] AND TCF21 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPEX7(137147607)-TCF21(134210556), # samples:2
Anticipated loss of major functional domain due to fusion event.PEX7-TCF21 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePEX7

GO:0016558

protein import into peroxisome matrix

9090381

TgeneTCF21

GO:0000122

negative regulation of transcription by RNA polymerase II

12493738


check buttonFusion gene breakpoints across PEX7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TCF21 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1N8-01APEX7chr6

137147607

+TCF21chr6

134210556

+
ChimerDB4BRCATCGA-E9-A1N8-01APEX7chr6

137167319

+TCF21chr6

134210556

+


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Fusion Gene ORF analysis for PEX7-TCF21

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000318471ENST00000237316PEX7chr6

137167319

+TCF21chr6

134210556

+
Frame-shiftENST00000318471ENST00000367882PEX7chr6

137147607

+TCF21chr6

134210556

+
Frame-shiftENST00000367756ENST00000367882PEX7chr6

137147607

+TCF21chr6

134210556

+
Frame-shiftENST00000541292ENST00000237316PEX7chr6

137167319

+TCF21chr6

134210556

+
Frame-shiftENST00000541292ENST00000367882PEX7chr6

137147607

+TCF21chr6

134210556

+
In-frameENST00000318471ENST00000237316PEX7chr6

137147607

+TCF21chr6

134210556

+
In-frameENST00000318471ENST00000367882PEX7chr6

137167319

+TCF21chr6

134210556

+
In-frameENST00000367756ENST00000237316PEX7chr6

137147607

+TCF21chr6

134210556

+
In-frameENST00000541292ENST00000237316PEX7chr6

137147607

+TCF21chr6

134210556

+
In-frameENST00000541292ENST00000367882PEX7chr6

137167319

+TCF21chr6

134210556

+
intron-3CDSENST00000367756ENST00000237316PEX7chr6

137167319

+TCF21chr6

134210556

+
intron-3CDSENST00000367756ENST00000367882PEX7chr6

137167319

+TCF21chr6

134210556

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000541292PEX7chr6137147607+ENST00000237316TCF21chr6134210556+335142586943285
ENST00000318471PEX7chr6137147607+ENST00000237316TCF21chr6134210556+334642081938285
ENST00000367756PEX7chr6137147607+ENST00000237316TCF21chr6134210556+335242687944285
ENST00000541292PEX7chr6137167319+ENST00000367882TCF21chr6134210556+48826123271130267
ENST00000318471PEX7chr6137167319+ENST00000367882TCF21chr6134210556+48776073221125267

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541292ENST00000237316PEX7chr6137147607+TCF21chr6134210556+0.0147291770.98527086
ENST00000318471ENST00000237316PEX7chr6137147607+TCF21chr6134210556+0.0149618080.9850382
ENST00000367756ENST00000237316PEX7chr6137147607+TCF21chr6134210556+0.0147296030.9852704
ENST00000541292ENST00000367882PEX7chr6137167319+TCF21chr6134210556+0.0027846950.9972153
ENST00000318471ENST00000367882PEX7chr6137167319+TCF21chr6134210556+0.0028050240.997195

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Fusion Genomic Features for PEX7-TCF21


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PEX7-TCF21


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:137147607/chr6:134210556)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePEX7chr6:137147607chr6:134210556ENST00000318471+31065_96113324.0RepeatNote=WD 1
HgenePEX7chr6:137167319chr6:134210556ENST00000318471+510109_141175324.0RepeatNote=WD 2
HgenePEX7chr6:137167319chr6:134210556ENST00000318471+51065_96175324.0RepeatNote=WD 1
TgeneTCF21chr6:137147607chr6:134210556ENST000002373160379_1310808.6666666666666DomainbHLH
TgeneTCF21chr6:137147607chr6:134210556ENST000003678820279_1310180.0DomainbHLH
TgeneTCF21chr6:137167319chr6:134210556ENST000002373160379_1310808.6666666666666DomainbHLH
TgeneTCF21chr6:137167319chr6:134210556ENST000003678820279_1310180.0DomainbHLH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePEX7chr6:137147607chr6:134210556ENST00000318471+310109_141113324.0RepeatNote=WD 2
HgenePEX7chr6:137147607chr6:134210556ENST00000318471+310153_184113324.0RepeatNote=WD 3
HgenePEX7chr6:137147607chr6:134210556ENST00000318471+310196_227113324.0RepeatNote=WD 4
HgenePEX7chr6:137147607chr6:134210556ENST00000318471+310240_271113324.0RepeatNote=WD 5
HgenePEX7chr6:137147607chr6:134210556ENST00000318471+310284_315113324.0RepeatNote=WD 6
HgenePEX7chr6:137167319chr6:134210556ENST00000318471+510153_184175324.0RepeatNote=WD 3
HgenePEX7chr6:137167319chr6:134210556ENST00000318471+510196_227175324.0RepeatNote=WD 4
HgenePEX7chr6:137167319chr6:134210556ENST00000318471+510240_271175324.0RepeatNote=WD 5
HgenePEX7chr6:137167319chr6:134210556ENST00000318471+510284_315175324.0RepeatNote=WD 6


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Fusion Gene Sequence for PEX7-TCF21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64391_64391_1_PEX7-TCF21_PEX7_chr6_137147607_ENST00000318471_TCF21_chr6_134210556_ENST00000237316_length(transcript)=3346nt_BP=420nt
TCTCTCTAACCGCGCCAGTGTGCCTCCGACTCGGAACGGCTTCCGCGGCCGGGGCAGCGAGGGCCGGGGGCGGCGGGCGGGATGAGTGCG
GTGTGCGGTGGAGCGGCGCGGATGCTGCGGACGCCGGGACGCCACGGCTACGCCGCCGAGTTCTCCCCGTACCTGCCGGGCCGCCTGGCC
TGCGCCACCGCGCAGCACTACGGCATCGCGGGCTGTGGAACCCTACTAATATTGGATCCAGATGAAGCTGGGCTAAGGCTTTTTAGAAGC
TTTGACTGGAATGATGGTTTGTTTGATGTGACTTGGAGTGAGAACAACGAACATGTCCTCATCACCTGTAGTGGCGATGGCTCGCTGCAG
CTCTGGGACACTGCCAAAGCTGCAGGGCCACTGCAAGTCTATAAAGAACACGCTCAGGAGGATGTGGAGGACCTTCAAGAGGTGGAGATG
TTGGAATGTGACGGGTTGAAAATGGATTCGAACAAGGAATTTGTGACTTCCAACGAGAGCACCGAGGAGAGCTCCAACTGCGAGAATGGG
TCTCCCCAGAAGGGCCGCGGCGGCCTGGGCAAGAGGAGGAAGGCGCCCACCAAGAAGAGCCCCCTGAGCGGGGTCAGCCAGGAGGGGAAG
CAGGTCCAGCGCAACGCCGCCAACGCGCGAGAGCGGGCCCGCATGCGAGTGCTGAGCAAGGCCTTCTCCAGACTCAAGACCACCCTGCCC
TGGGTGCCCCCCGACACCAAGCTCTCCAAGCTGGACACGCTCAGGCTGGCGTCCAGCTACATCGCCCACTTGAGGCAGATCCTGGCTAAC
GACAAATACGAGAACGGGTACATTCACCCGGTCAACCTGACGTGGCCCTTTATGGTGGCCGGGAAACCCGAGAGTGACCTGAAAGAAGTG
GTGACCGCGAGCCGCTTATGTGGAACCACCGCGTCCTGACCTTGGAGTTTGGTACCTGGAGCGAGAGCTTCTCCGCCCTTCCACCAACCC
CACAGGCCGCTTCGCGGGTGGAGCCCTCTGCCTGGCCATGGAGGAAGGATCCCGCTAGGCTGGTCCCGACTGGAGAAGCTGCTCTGCCAG
GTGTGCTCTCTGTCAGCAATAGTGACCTCATTACCAAGGGGTGGCGACCACATTACCAAGCGCAATTCCCCATTCTCCAAGGGCTGAGAA
CTTCGGTGACTTCATCCACCTGTCTATTTGCACATGGAGGACTTTTCAAGATGTCAGGATACCCTTCCATCACCCCACCACCGCCACCCC
AACTTGACTTTCAAGAACACATTTCAAGCTCTGGCCAGAGTCCCGTTCCTCAAATTCATGTGTTCTCTCCTTTCTACCAGAGGGATAGAG
CCCATGCCTCAACCTATCCAGAGTTCAAATCAAAGAGTCCCCAGTGTGATTCAATTGATTGCCTTTCACGTTTCGCAAATTTTCCAATCT
CCCACTCACGTTTTTACAAAACGAATGCTCTAAATTCTGAGGATTCCAGGCAGGCCATCCATAGAGAAATAACTTTTTCTTGCTCATTCC
CTTACAACCCCAATCTATACATGGATTTTTAGAAAGTCTTCATGGCTATCTATAGTTCCCTACCAATAATTTGAAGCCTTTGCTTTAGGC
AGGAGGCATGTGGCTATGAATAGGGAACACGTAGATTTGACCCTGGTTCTGCATCCAACTAGCTGTTTCTTGAAAGAGCCTGGATCCTCA
GTTTTCCCATCTCTGCAAGCAGGGATAACGGTAATGAGAATGATAATAATCATTATATGCAGACCTTCCTCTTTCATCTTACAGAGGCTT
AGTGAGGCTCAGATGAGATTATATCTGTAAAATCCCTTGGTAAAGGAAAAGCTCCGTGAAAATGTCAGTTACTTTTACTAAGTGGCGGGT
AGTGAATTATCTGTGCCTAGACCCAAACTGAAAGTGTCTCAGGCAGGAAGTTCCAAGGGATGTATGTTTATAGCATCCAGGCAATGATCT
TTTTTTTTCCACGAACTAAAATACCTCTTTTTGGTATCTATTGACTCTTTCTCTCTCTCTTTCTGTCTCTCTTTCACCTTGCACCTCTCC
CTAATGCTCTCTAAATTTGTCCAGAGCTTTCTTTTTCCTAGAAATCCAGAGAGCAAAGTCAGAGCCTGGCACCTGCAGATAGGATAACAC
TGGTGTCTGATGGTGAGGCTGCCCAGTCCCATCAGGAGCCTCAGCCAAGGAGGGGCCTGGGCACACTCAGGTCCCCATGGTTGTCCATTG
AATGGAGTGAGGATCAAGGTGGGAATGACTGGGTGGTGGCTGCCACTAGCCCAGGAACATGACAACGTGACCACACCACACATGCCTCCA
ACACACACCCACAGTCTAAACATCTCTCCTTCTCAGTGAGCCCTTCTCCCATTCCAGATCATCAGCACACCCACACCCACCATAGGTCTC
TCTCCTCCGGTCTTCCCAGAAGGGTAAAACTCCCAGCCTACCCTGCTCCAGCTTCAGCCCAGGTAGTTGGTGTGTCTCAATATGAATAGG
GGGTGAGTAGCTTCATAGAAAGAATGGGGAACTCCCTTGGCCTCAAGCCAGTATAGTTTGGAAGTTGGGGGTCGGGGATGTTAAGGGTGG
GGAGTATCCTGCCTGTGACCTCTAGGTTATGAAAACTATCTTAGAAGGTGCTTTTAGAAAGAACCAGGAGAACAACCAAAGCAGCTTACA
GACGCCTGAACGGAGAATGAAGTGTTTCAAGTAAGCGAGTCTGCAAGTTCTCAGAAGCAGACAGATATCCAATCTGGACTGCAGCCAGGG
AAGTCCTCTCTCTCGCTCTCTCTCTCTCTCTCTCTCTCTCTCATTGCTTGTATGACTTCACAAGCAACTCAGGATCATTCTAGCAGGCTT
TCCCACTGTCAAACAGAGACTTCATTCTAAAAAGAGAAGTGATAAACAGAGCTCCAGCTCTGCTAGCTCTATATATTTACTGATTAGTGG
AAAGCACTGACCAAGGAGACTTTTAAGCCAGTGGTTCTTCAGAATCACCTAGATGCCTCCACCCTCCAGAGATCCTGAGTCCAGGAGTCT
GAAGTGGGGCCCCAGGTGATGTCATTGCTGCTGGTCCCAGGACCACATTTTAACAATCAATGTTTTCAGGTGTCTCATGAGGAACACTAC
TTAATGCAGTGGGAAAGAAAATATTTCAGAGGAGAATTTTTTCTTAAAGAAGCTGCATATTCTGGACTCTAATTTAGTTTAATTCACTCC
AGGATGGCACGCAGGATTCCTAATTCTTAAATGCCATTCAGTCTGGACTTCAAATCACTTGTCTTCAGAAAATAAAAGATTTGTTCCACC

>64391_64391_1_PEX7-TCF21_PEX7_chr6_137147607_ENST00000318471_TCF21_chr6_134210556_ENST00000237316_length(amino acids)=285AA_BP=113
MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDG
SLQLWDTAKAAGPLQVYKEHAQEDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQ
EGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPESDL

--------------------------------------------------------------
>64391_64391_2_PEX7-TCF21_PEX7_chr6_137147607_ENST00000367756_TCF21_chr6_134210556_ENST00000237316_length(transcript)=3352nt_BP=426nt
GCCTGGTCTCTCTAACCGCGCCAGTGTGCCTCCGACTCGGAACGGCTTCCGCGGCCGGGGCAGCGAGGGCCGGGGGCGGCGGGCGGGATG
AGTGCGGTGTGCGGTGGAGCGGCGCGGATGCTGCGGACGCCGGGACGCCACGGCTACGCCGCCGAGTTCTCCCCGTACCTGCCGGGCCGC
CTGGCCTGCGCCACCGCGCAGCACTACGGCATCGCGGGCTGTGGAACCCTACTAATATTGGATCCAGATGAAGCTGGGCTAAGGCTTTTT
AGAAGCTTTGACTGGAATGATGGTTTGTTTGATGTGACTTGGAGTGAGAACAACGAACATGTCCTCATCACCTGTAGTGGCGATGGCTCG
CTGCAGCTCTGGGACACTGCCAAAGCTGCAGGGCCACTGCAAGTCTATAAAGAACACGCTCAGGAGGATGTGGAGGACCTTCAAGAGGTG
GAGATGTTGGAATGTGACGGGTTGAAAATGGATTCGAACAAGGAATTTGTGACTTCCAACGAGAGCACCGAGGAGAGCTCCAACTGCGAG
AATGGGTCTCCCCAGAAGGGCCGCGGCGGCCTGGGCAAGAGGAGGAAGGCGCCCACCAAGAAGAGCCCCCTGAGCGGGGTCAGCCAGGAG
GGGAAGCAGGTCCAGCGCAACGCCGCCAACGCGCGAGAGCGGGCCCGCATGCGAGTGCTGAGCAAGGCCTTCTCCAGACTCAAGACCACC
CTGCCCTGGGTGCCCCCCGACACCAAGCTCTCCAAGCTGGACACGCTCAGGCTGGCGTCCAGCTACATCGCCCACTTGAGGCAGATCCTG
GCTAACGACAAATACGAGAACGGGTACATTCACCCGGTCAACCTGACGTGGCCCTTTATGGTGGCCGGGAAACCCGAGAGTGACCTGAAA
GAAGTGGTGACCGCGAGCCGCTTATGTGGAACCACCGCGTCCTGACCTTGGAGTTTGGTACCTGGAGCGAGAGCTTCTCCGCCCTTCCAC
CAACCCCACAGGCCGCTTCGCGGGTGGAGCCCTCTGCCTGGCCATGGAGGAAGGATCCCGCTAGGCTGGTCCCGACTGGAGAAGCTGCTC
TGCCAGGTGTGCTCTCTGTCAGCAATAGTGACCTCATTACCAAGGGGTGGCGACCACATTACCAAGCGCAATTCCCCATTCTCCAAGGGC
TGAGAACTTCGGTGACTTCATCCACCTGTCTATTTGCACATGGAGGACTTTTCAAGATGTCAGGATACCCTTCCATCACCCCACCACCGC
CACCCCAACTTGACTTTCAAGAACACATTTCAAGCTCTGGCCAGAGTCCCGTTCCTCAAATTCATGTGTTCTCTCCTTTCTACCAGAGGG
ATAGAGCCCATGCCTCAACCTATCCAGAGTTCAAATCAAAGAGTCCCCAGTGTGATTCAATTGATTGCCTTTCACGTTTCGCAAATTTTC
CAATCTCCCACTCACGTTTTTACAAAACGAATGCTCTAAATTCTGAGGATTCCAGGCAGGCCATCCATAGAGAAATAACTTTTTCTTGCT
CATTCCCTTACAACCCCAATCTATACATGGATTTTTAGAAAGTCTTCATGGCTATCTATAGTTCCCTACCAATAATTTGAAGCCTTTGCT
TTAGGCAGGAGGCATGTGGCTATGAATAGGGAACACGTAGATTTGACCCTGGTTCTGCATCCAACTAGCTGTTTCTTGAAAGAGCCTGGA
TCCTCAGTTTTCCCATCTCTGCAAGCAGGGATAACGGTAATGAGAATGATAATAATCATTATATGCAGACCTTCCTCTTTCATCTTACAG
AGGCTTAGTGAGGCTCAGATGAGATTATATCTGTAAAATCCCTTGGTAAAGGAAAAGCTCCGTGAAAATGTCAGTTACTTTTACTAAGTG
GCGGGTAGTGAATTATCTGTGCCTAGACCCAAACTGAAAGTGTCTCAGGCAGGAAGTTCCAAGGGATGTATGTTTATAGCATCCAGGCAA
TGATCTTTTTTTTTCCACGAACTAAAATACCTCTTTTTGGTATCTATTGACTCTTTCTCTCTCTCTTTCTGTCTCTCTTTCACCTTGCAC
CTCTCCCTAATGCTCTCTAAATTTGTCCAGAGCTTTCTTTTTCCTAGAAATCCAGAGAGCAAAGTCAGAGCCTGGCACCTGCAGATAGGA
TAACACTGGTGTCTGATGGTGAGGCTGCCCAGTCCCATCAGGAGCCTCAGCCAAGGAGGGGCCTGGGCACACTCAGGTCCCCATGGTTGT
CCATTGAATGGAGTGAGGATCAAGGTGGGAATGACTGGGTGGTGGCTGCCACTAGCCCAGGAACATGACAACGTGACCACACCACACATG
CCTCCAACACACACCCACAGTCTAAACATCTCTCCTTCTCAGTGAGCCCTTCTCCCATTCCAGATCATCAGCACACCCACACCCACCATA
GGTCTCTCTCCTCCGGTCTTCCCAGAAGGGTAAAACTCCCAGCCTACCCTGCTCCAGCTTCAGCCCAGGTAGTTGGTGTGTCTCAATATG
AATAGGGGGTGAGTAGCTTCATAGAAAGAATGGGGAACTCCCTTGGCCTCAAGCCAGTATAGTTTGGAAGTTGGGGGTCGGGGATGTTAA
GGGTGGGGAGTATCCTGCCTGTGACCTCTAGGTTATGAAAACTATCTTAGAAGGTGCTTTTAGAAAGAACCAGGAGAACAACCAAAGCAG
CTTACAGACGCCTGAACGGAGAATGAAGTGTTTCAAGTAAGCGAGTCTGCAAGTTCTCAGAAGCAGACAGATATCCAATCTGGACTGCAG
CCAGGGAAGTCCTCTCTCTCGCTCTCTCTCTCTCTCTCTCTCTCTCTCATTGCTTGTATGACTTCACAAGCAACTCAGGATCATTCTAGC
AGGCTTTCCCACTGTCAAACAGAGACTTCATTCTAAAAAGAGAAGTGATAAACAGAGCTCCAGCTCTGCTAGCTCTATATATTTACTGAT
TAGTGGAAAGCACTGACCAAGGAGACTTTTAAGCCAGTGGTTCTTCAGAATCACCTAGATGCCTCCACCCTCCAGAGATCCTGAGTCCAG
GAGTCTGAAGTGGGGCCCCAGGTGATGTCATTGCTGCTGGTCCCAGGACCACATTTTAACAATCAATGTTTTCAGGTGTCTCATGAGGAA
CACTACTTAATGCAGTGGGAAAGAAAATATTTCAGAGGAGAATTTTTTCTTAAAGAAGCTGCATATTCTGGACTCTAATTTAGTTTAATT
CACTCCAGGATGGCACGCAGGATTCCTAATTCTTAAATGCCATTCAGTCTGGACTTCAAATCACTTGTCTTCAGAAAATAAAAGATTTGT

>64391_64391_2_PEX7-TCF21_PEX7_chr6_137147607_ENST00000367756_TCF21_chr6_134210556_ENST00000237316_length(amino acids)=285AA_BP=113
MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDG
SLQLWDTAKAAGPLQVYKEHAQEDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQ
EGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPESDL

--------------------------------------------------------------
>64391_64391_3_PEX7-TCF21_PEX7_chr6_137147607_ENST00000541292_TCF21_chr6_134210556_ENST00000237316_length(transcript)=3351nt_BP=425nt
CCTGGTCTCTCTAACCGCGCCAGTGTGCCTCCGACTCGGAACGGCTTCCGCGGCCGGGGCAGCGAGGGCCGGGGGCGGCGGGCGGGATGA
GTGCGGTGTGCGGTGGAGCGGCGCGGATGCTGCGGACGCCGGGACGCCACGGCTACGCCGCCGAGTTCTCCCCGTACCTGCCGGGCCGCC
TGGCCTGCGCCACCGCGCAGCACTACGGCATCGCGGGCTGTGGAACCCTACTAATATTGGATCCAGATGAAGCTGGGCTAAGGCTTTTTA
GAAGCTTTGACTGGAATGATGGTTTGTTTGATGTGACTTGGAGTGAGAACAACGAACATGTCCTCATCACCTGTAGTGGCGATGGCTCGC
TGCAGCTCTGGGACACTGCCAAAGCTGCAGGGCCACTGCAAGTCTATAAAGAACACGCTCAGGAGGATGTGGAGGACCTTCAAGAGGTGG
AGATGTTGGAATGTGACGGGTTGAAAATGGATTCGAACAAGGAATTTGTGACTTCCAACGAGAGCACCGAGGAGAGCTCCAACTGCGAGA
ATGGGTCTCCCCAGAAGGGCCGCGGCGGCCTGGGCAAGAGGAGGAAGGCGCCCACCAAGAAGAGCCCCCTGAGCGGGGTCAGCCAGGAGG
GGAAGCAGGTCCAGCGCAACGCCGCCAACGCGCGAGAGCGGGCCCGCATGCGAGTGCTGAGCAAGGCCTTCTCCAGACTCAAGACCACCC
TGCCCTGGGTGCCCCCCGACACCAAGCTCTCCAAGCTGGACACGCTCAGGCTGGCGTCCAGCTACATCGCCCACTTGAGGCAGATCCTGG
CTAACGACAAATACGAGAACGGGTACATTCACCCGGTCAACCTGACGTGGCCCTTTATGGTGGCCGGGAAACCCGAGAGTGACCTGAAAG
AAGTGGTGACCGCGAGCCGCTTATGTGGAACCACCGCGTCCTGACCTTGGAGTTTGGTACCTGGAGCGAGAGCTTCTCCGCCCTTCCACC
AACCCCACAGGCCGCTTCGCGGGTGGAGCCCTCTGCCTGGCCATGGAGGAAGGATCCCGCTAGGCTGGTCCCGACTGGAGAAGCTGCTCT
GCCAGGTGTGCTCTCTGTCAGCAATAGTGACCTCATTACCAAGGGGTGGCGACCACATTACCAAGCGCAATTCCCCATTCTCCAAGGGCT
GAGAACTTCGGTGACTTCATCCACCTGTCTATTTGCACATGGAGGACTTTTCAAGATGTCAGGATACCCTTCCATCACCCCACCACCGCC
ACCCCAACTTGACTTTCAAGAACACATTTCAAGCTCTGGCCAGAGTCCCGTTCCTCAAATTCATGTGTTCTCTCCTTTCTACCAGAGGGA
TAGAGCCCATGCCTCAACCTATCCAGAGTTCAAATCAAAGAGTCCCCAGTGTGATTCAATTGATTGCCTTTCACGTTTCGCAAATTTTCC
AATCTCCCACTCACGTTTTTACAAAACGAATGCTCTAAATTCTGAGGATTCCAGGCAGGCCATCCATAGAGAAATAACTTTTTCTTGCTC
ATTCCCTTACAACCCCAATCTATACATGGATTTTTAGAAAGTCTTCATGGCTATCTATAGTTCCCTACCAATAATTTGAAGCCTTTGCTT
TAGGCAGGAGGCATGTGGCTATGAATAGGGAACACGTAGATTTGACCCTGGTTCTGCATCCAACTAGCTGTTTCTTGAAAGAGCCTGGAT
CCTCAGTTTTCCCATCTCTGCAAGCAGGGATAACGGTAATGAGAATGATAATAATCATTATATGCAGACCTTCCTCTTTCATCTTACAGA
GGCTTAGTGAGGCTCAGATGAGATTATATCTGTAAAATCCCTTGGTAAAGGAAAAGCTCCGTGAAAATGTCAGTTACTTTTACTAAGTGG
CGGGTAGTGAATTATCTGTGCCTAGACCCAAACTGAAAGTGTCTCAGGCAGGAAGTTCCAAGGGATGTATGTTTATAGCATCCAGGCAAT
GATCTTTTTTTTTCCACGAACTAAAATACCTCTTTTTGGTATCTATTGACTCTTTCTCTCTCTCTTTCTGTCTCTCTTTCACCTTGCACC
TCTCCCTAATGCTCTCTAAATTTGTCCAGAGCTTTCTTTTTCCTAGAAATCCAGAGAGCAAAGTCAGAGCCTGGCACCTGCAGATAGGAT
AACACTGGTGTCTGATGGTGAGGCTGCCCAGTCCCATCAGGAGCCTCAGCCAAGGAGGGGCCTGGGCACACTCAGGTCCCCATGGTTGTC
CATTGAATGGAGTGAGGATCAAGGTGGGAATGACTGGGTGGTGGCTGCCACTAGCCCAGGAACATGACAACGTGACCACACCACACATGC
CTCCAACACACACCCACAGTCTAAACATCTCTCCTTCTCAGTGAGCCCTTCTCCCATTCCAGATCATCAGCACACCCACACCCACCATAG
GTCTCTCTCCTCCGGTCTTCCCAGAAGGGTAAAACTCCCAGCCTACCCTGCTCCAGCTTCAGCCCAGGTAGTTGGTGTGTCTCAATATGA
ATAGGGGGTGAGTAGCTTCATAGAAAGAATGGGGAACTCCCTTGGCCTCAAGCCAGTATAGTTTGGAAGTTGGGGGTCGGGGATGTTAAG
GGTGGGGAGTATCCTGCCTGTGACCTCTAGGTTATGAAAACTATCTTAGAAGGTGCTTTTAGAAAGAACCAGGAGAACAACCAAAGCAGC
TTACAGACGCCTGAACGGAGAATGAAGTGTTTCAAGTAAGCGAGTCTGCAAGTTCTCAGAAGCAGACAGATATCCAATCTGGACTGCAGC
CAGGGAAGTCCTCTCTCTCGCTCTCTCTCTCTCTCTCTCTCTCTCTCATTGCTTGTATGACTTCACAAGCAACTCAGGATCATTCTAGCA
GGCTTTCCCACTGTCAAACAGAGACTTCATTCTAAAAAGAGAAGTGATAAACAGAGCTCCAGCTCTGCTAGCTCTATATATTTACTGATT
AGTGGAAAGCACTGACCAAGGAGACTTTTAAGCCAGTGGTTCTTCAGAATCACCTAGATGCCTCCACCCTCCAGAGATCCTGAGTCCAGG
AGTCTGAAGTGGGGCCCCAGGTGATGTCATTGCTGCTGGTCCCAGGACCACATTTTAACAATCAATGTTTTCAGGTGTCTCATGAGGAAC
ACTACTTAATGCAGTGGGAAAGAAAATATTTCAGAGGAGAATTTTTTCTTAAAGAAGCTGCATATTCTGGACTCTAATTTAGTTTAATTC
ACTCCAGGATGGCACGCAGGATTCCTAATTCTTAAATGCCATTCAGTCTGGACTTCAAATCACTTGTCTTCAGAAAATAAAAGATTTGTT

>64391_64391_3_PEX7-TCF21_PEX7_chr6_137147607_ENST00000541292_TCF21_chr6_134210556_ENST00000237316_length(amino acids)=285AA_BP=113
MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDG
SLQLWDTAKAAGPLQVYKEHAQEDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQ
EGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPESDL

--------------------------------------------------------------
>64391_64391_4_PEX7-TCF21_PEX7_chr6_137167319_ENST00000318471_TCF21_chr6_134210556_ENST00000367882_length(transcript)=4877nt_BP=607nt
TCTCTCTAACCGCGCCAGTGTGCCTCCGACTCGGAACGGCTTCCGCGGCCGGGGCAGCGAGGGCCGGGGGCGGCGGGCGGGATGAGTGCG
GTGTGCGGTGGAGCGGCGCGGATGCTGCGGACGCCGGGACGCCACGGCTACGCCGCCGAGTTCTCCCCGTACCTGCCGGGCCGCCTGGCC
TGCGCCACCGCGCAGCACTACGGCATCGCGGGCTGTGGAACCCTACTAATATTGGATCCAGATGAAGCTGGGCTAAGGCTTTTTAGAAGC
TTTGACTGGAATGATGGTTTGTTTGATGTGACTTGGAGTGAGAACAACGAACATGTCCTCATCACCTGTAGTGGCGATGGCTCGCTGCAG
CTCTGGGACACTGCCAAAGCTGCAGGGCCACTGCAAGTCTATAAAGAACACGCTCAGGAGGTGTATAGTGTTGATTGGAGCCAAACCAGA
GGTGAACAGCTTGTGGTGTCTGGCTCATGGGATCAAACTGTCAAATTGTGGGATCCAACTGTTGGAAAGTCTCTGTGCACCTTTAGAGGC
CATGAAAGTATTATTTATAGCACAATCTGGTCTCCCCACATCCCTGGTTGTTTTGCTTCAGCCTCAGGATGTGGAGGACCTTCAAGAGGT
GGAGATGTTGGAATGTGACGGGTTGAAAATGGATTCGAACAAGGAATTTGTGACTTCCAACGAGAGCACCGAGGAGAGCTCCAACTGCGA
GAATGGGTCTCCCCAGAAGGGCCGCGGCGGCCTGGGCAAGAGGAGGAAGGCGCCCACCAAGAAGAGCCCCCTGAGCGGGGTCAGCCAGGA
GGGGAAGCAGGTCCAGCGCAACGCCGCCAACGCGCGAGAGCGGGCCCGCATGCGAGTGCTGAGCAAGGCCTTCTCCAGACTCAAGACCAC
CCTGCCCTGGGTGCCCCCCGACACCAAGCTCTCCAAGCTGGACACGCTCAGGCTGGCGTCCAGCTACATCGCCCACTTGAGGCAGATCCT
GGCTAACGACAAATACGAGAACGGGTACATTCACCCGGTCAACCTGACGTGGCCCTTTATGGTGGCCGGGAAACCCGAGAGTGACCTGAA
AGAAGTGGTGACCGCGAGCCGCTTATGTGGAACCACCGCGTCCTGACCTTGGAGGTGCGAGTCTGGGAAAGGCGCGCTCCCGGGGGGAGC
GGGCCCCGGGAAGGCGACCCCTGCCCTCAGTGCTCTCTGTCTCTGCTTCCCCCTCGCAATGCTCCTCTCTCTGTCCCACCCCGCGAGAAC
ACTTTACAACGACGAGGAGATTCGTTTCCAAACCAGAGGAGATCAATTGTACTTACAAAGATTCCCATCTATTTAACTTTATTAACTTCT
ACCGTGAATGACTCTGCAAGCCTTGCTGGTCCAAGTGCAATATGTAATTATAAATATATAAATAGATAAGAGCCTATCAATGTATCTTTT
GTACAATATGTTGTAAAATGTAGATCATAGGATAGCTGACTTTGACAGTCACATTTATAAAGTAATTCACTTAAAGATATATATTTTTTT
CAAACAAGTTTTGCTACTTTTGAAAATAAATCTTTCTTTATATTGCTAAAAGCTCTGATATTTGGAGTGATTTTTAAAAATATTTGGAAT
AAGAAAGTGGGAAACTATGGGGAAGCTTGATAATGAAAATGGTTCTTTTAAACCTCAATCTAAACTTCTAGAGATAGAAGAAAATTGCAT
ATGAGTTTCATAATGAAGATGCAGATTATGTTTTATACTGAAACCTTAAAAAAGAAATATATCGGTTACTTTTAAGGCTAATAGAAATTA
TATAACTGAAAACAAAGAATGGGCAGTATTAAAGTTATCCACAGTTATACAGTTCAAGAGTAAAACGCACCAGAAAAAGGAAATCCAATT
TTCATGGATTCCACCGTATGACTGCTGACACGGGCGAGAAAGTAAACTCCACCTTTTGTCACCTTCCAGGTGTGAGCATAGCTGCAAACT
AGTGAAGAAATAATAGAAGCTATGAAAGATGTAAATTCCATAACCCTTAGGGTGTGTTTCAGGATTTTCAAAGCTCTGCAGCATACATTA
TCTACATTTCTTATTAATAGTCCATTAATTAATTCTAACAATAAACCCGCATGCCTGCCTTTTGGTTGCTGTTAGCGGGTGCGTTTAGCT
CCCGCCACGACTTCCGGCGGACTGGGTTTAATTTAAACATTTTCCAGGCTACGGAACAGCTCCTAAGGGAAGATTAAGTTGAGATAAACA
GAGAAGCAAGGCCGAGGAGCCTGCGACCCGGGTCCCTCACTGCCCCAGCGCAGCCCGCGGCGGCCGATGCGCCAGATGCCACCGGGGCTG
TTTAATGTTCGGGGTTATGACCGCAGTGTTTACAAGACGTCTTCGGTTATTTATACTGTTATTCCTCGCAGAGAGCCTTGAAACTTCCGC
TTCATTTGCTCTTTCTTTTCGATTTTTTACCCTTTTTTCTCGGCTTAGTTTGGTACCTGGAGCGAGAGCTTCTCCGCCCTTCCACCAACC
CCACAGGCCGCTTCGCGGGTGGAGCCCTCTGCCTGGCCATGGAGGAAGGATCCCGCTAGGCTGGTCCCGACTGGAGAAGCTGCTCTGCCA
GGTGTGCTCTCTGTCAGCAATAGTGACCTCATTACCAAGGGGTGGCGACCACATTACCAAGCGCAATTCCCCATTCTCCAAGGGCTGAGA
ACTTCGGTGACTTCATCCACCTGTCTATTTGCACATGGAGGACTTTTCAAGATGTCAGGATACCCTTCCATCACCCCACCACCGCCACCC
CAACTTGACTTTCAAGAACACATTTCAAGCTCTGGCCAGAGTCCCGTTCCTCAAATTCATGTGTTCTCTCCTTTCTACCAGAGGGATAGA
GCCCATGCCTCAACCTATCCAGAGTTCAAATCAAAGAGTCCCCAGTGTGATTCAATTGATTGCCTTTCACGTTTCGCAAATTTTCCAATC
TCCCACTCACGTTTTTACAAAACGAATGCTCTAAATTCTGAGGATTCCAGGCAGGCCATCCATAGAGAAATAACTTTTTCTTGCTCATTC
CCTTACAACCCCAATCTATACATGGATTTTTAGAAAGTCTTCATGGCTATCTATAGTTCCCTACCAATAATTTGAAGCCTTTGCTTTAGG
CAGGAGGCATGTGGCTATGAATAGGGAACACGTAGATTTGACCCTGGTTCTGCATCCAACTAGCTGTTTCTTGAAAGAGCCTGGATCCTC
AGTTTTCCCATCTCTGCAAGCAGGGATAACGGTAATGAGAATGATAATAATCATTATATGCAGACCTTCCTCTTTCATCTTACAGAGGCT
TAGTGAGGCTCAGATGAGATTATATCTGTAAAATCCCTTGGTAAAGGAAAAGCTCCGTGAAAATGTCAGTTACTTTTACTAAGTGGCGGG
TAGTGAATTATCTGTGCCTAGACCCAAACTGAAAGTGTCTCAGGCAGGAAGTTCCAAGGGATGTATGTTTATAGCATCCAGGCAATGATC
TTTTTTTTTCCACGAACTAAAATACCTCTTTTTGGTATCTATTGACTCTTTCTCTCTCTCTTTCTGTCTCTCTTTCACCTTGCACCTCTC
CCTAATGCTCTCTAAATTTGTCCAGAGCTTTCTTTTTCCTAGAAATCCAGAGAGCAAAGTCAGAGCCTGGCACCTGCAGATAGGATAACA
CTGGTGTCTGATGGTGAGGCTGCCCAGTCCCATCAGGAGCCTCAGCCAAGGAGGGGCCTGGGCACACTCAGGTCCCCATGGTTGTCCATT
GAATGGAGTGAGGATCAAGGTGGGAATGACTGGGTGGTGGCTGCCACTAGCCCAGGAACATGACAACGTGACCACACCACACATGCCTCC
AACACACACCCACAGTCTAAACATCTCTCCTTCTCAGTGAGCCCTTCTCCCATTCCAGATCATCAGCACACCCACACCCACCATAGGTCT
CTCTCCTCCGGTCTTCCCAGAAGGGTAAAACTCCCAGCCTACCCTGCTCCAGCTTCAGCCCAGGTAGTTGGTGTGTCTCAATATGAATAG
GGGGTGAGTAGCTTCATAGAAAGAATGGGGAACTCCCTTGGCCTCAAGCCAGTATAGTTTGGAAGTTGGGGGTCGGGGATGTTAAGGGTG
GGGAGTATCCTGCCTGTGACCTCTAGGTTATGAAAACTATCTTAGAAGGTGCTTTTAGAAAGAACCAGGAGAACAACCAAAGCAGCTTAC
AGACGCCTGAACGGAGAATGAAGTGTTTCAAGTAAGCGAGTCTGCAAGTTCTCAGAAGCAGACAGATATCCAATCTGGACTGCAGCCAGG
GAAGTCCTCTCTCTCGCTCTCTCTCTCTCTCTCTCTCTCTCTCATTGCTTGTATGACTTCACAAGCAACTCAGGATCATTCTAGCAGGCT
TTCCCACTGTCAAACAGAGACTTCATTCTAAAAAGAGAAGTGATAAACAGAGCTCCAGCTCTGCTAGCTCTATATATTTACTGATTAGTG
GAAAGCACTGACCAAGGAGACTTTTAAGCCAGTGGTTCTTCAGAATCACCTAGATGCCTCCACCCTCCAGAGATCCTGAGTCCAGGAGTC
TGAAGTGGGGCCCCAGGTGATGTCATTGCTGCTGGTCCCAGGACCACATTTTAACAATCAATGTTTTCAGGTGTCTCATGAGGAACACTA
CTTAATGCAGTGGGAAAGAAAATATTTCAGAGGAGAATTTTTTCTTAAAGAAGCTGCATATTCTGGACTCTAATTTAGTTTAATTCACTC
CAGGATGGCACGCAGGATTCCTAATTCTTAAATGCCATTCAGTCTGGACTTCAAATCACTTGTCTTCAGAAAATAAAAGATTTGTTCCAC

>64391_64391_4_PEX7-TCF21_PEX7_chr6_137167319_ENST00000318471_TCF21_chr6_134210556_ENST00000367882_length(amino acids)=267AA_BP=95
MSSSPVVAMARCSSGTLPKLQGHCKSIKNTLRRCIVLIGAKPEVNSLWCLAHGIKLSNCGIQLLESLCAPLEAMKVLFIAQSGLPTSLVV
LLQPQDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARM

--------------------------------------------------------------
>64391_64391_5_PEX7-TCF21_PEX7_chr6_137167319_ENST00000541292_TCF21_chr6_134210556_ENST00000367882_length(transcript)=4882nt_BP=612nt
CCTGGTCTCTCTAACCGCGCCAGTGTGCCTCCGACTCGGAACGGCTTCCGCGGCCGGGGCAGCGAGGGCCGGGGGCGGCGGGCGGGATGA
GTGCGGTGTGCGGTGGAGCGGCGCGGATGCTGCGGACGCCGGGACGCCACGGCTACGCCGCCGAGTTCTCCCCGTACCTGCCGGGCCGCC
TGGCCTGCGCCACCGCGCAGCACTACGGCATCGCGGGCTGTGGAACCCTACTAATATTGGATCCAGATGAAGCTGGGCTAAGGCTTTTTA
GAAGCTTTGACTGGAATGATGGTTTGTTTGATGTGACTTGGAGTGAGAACAACGAACATGTCCTCATCACCTGTAGTGGCGATGGCTCGC
TGCAGCTCTGGGACACTGCCAAAGCTGCAGGGCCACTGCAAGTCTATAAAGAACACGCTCAGGAGGTGTATAGTGTTGATTGGAGCCAAA
CCAGAGGTGAACAGCTTGTGGTGTCTGGCTCATGGGATCAAACTGTCAAATTGTGGGATCCAACTGTTGGAAAGTCTCTGTGCACCTTTA
GAGGCCATGAAAGTATTATTTATAGCACAATCTGGTCTCCCCACATCCCTGGTTGTTTTGCTTCAGCCTCAGGATGTGGAGGACCTTCAA
GAGGTGGAGATGTTGGAATGTGACGGGTTGAAAATGGATTCGAACAAGGAATTTGTGACTTCCAACGAGAGCACCGAGGAGAGCTCCAAC
TGCGAGAATGGGTCTCCCCAGAAGGGCCGCGGCGGCCTGGGCAAGAGGAGGAAGGCGCCCACCAAGAAGAGCCCCCTGAGCGGGGTCAGC
CAGGAGGGGAAGCAGGTCCAGCGCAACGCCGCCAACGCGCGAGAGCGGGCCCGCATGCGAGTGCTGAGCAAGGCCTTCTCCAGACTCAAG
ACCACCCTGCCCTGGGTGCCCCCCGACACCAAGCTCTCCAAGCTGGACACGCTCAGGCTGGCGTCCAGCTACATCGCCCACTTGAGGCAG
ATCCTGGCTAACGACAAATACGAGAACGGGTACATTCACCCGGTCAACCTGACGTGGCCCTTTATGGTGGCCGGGAAACCCGAGAGTGAC
CTGAAAGAAGTGGTGACCGCGAGCCGCTTATGTGGAACCACCGCGTCCTGACCTTGGAGGTGCGAGTCTGGGAAAGGCGCGCTCCCGGGG
GGAGCGGGCCCCGGGAAGGCGACCCCTGCCCTCAGTGCTCTCTGTCTCTGCTTCCCCCTCGCAATGCTCCTCTCTCTGTCCCACCCCGCG
AGAACACTTTACAACGACGAGGAGATTCGTTTCCAAACCAGAGGAGATCAATTGTACTTACAAAGATTCCCATCTATTTAACTTTATTAA
CTTCTACCGTGAATGACTCTGCAAGCCTTGCTGGTCCAAGTGCAATATGTAATTATAAATATATAAATAGATAAGAGCCTATCAATGTAT
CTTTTGTACAATATGTTGTAAAATGTAGATCATAGGATAGCTGACTTTGACAGTCACATTTATAAAGTAATTCACTTAAAGATATATATT
TTTTTCAAACAAGTTTTGCTACTTTTGAAAATAAATCTTTCTTTATATTGCTAAAAGCTCTGATATTTGGAGTGATTTTTAAAAATATTT
GGAATAAGAAAGTGGGAAACTATGGGGAAGCTTGATAATGAAAATGGTTCTTTTAAACCTCAATCTAAACTTCTAGAGATAGAAGAAAAT
TGCATATGAGTTTCATAATGAAGATGCAGATTATGTTTTATACTGAAACCTTAAAAAAGAAATATATCGGTTACTTTTAAGGCTAATAGA
AATTATATAACTGAAAACAAAGAATGGGCAGTATTAAAGTTATCCACAGTTATACAGTTCAAGAGTAAAACGCACCAGAAAAAGGAAATC
CAATTTTCATGGATTCCACCGTATGACTGCTGACACGGGCGAGAAAGTAAACTCCACCTTTTGTCACCTTCCAGGTGTGAGCATAGCTGC
AAACTAGTGAAGAAATAATAGAAGCTATGAAAGATGTAAATTCCATAACCCTTAGGGTGTGTTTCAGGATTTTCAAAGCTCTGCAGCATA
CATTATCTACATTTCTTATTAATAGTCCATTAATTAATTCTAACAATAAACCCGCATGCCTGCCTTTTGGTTGCTGTTAGCGGGTGCGTT
TAGCTCCCGCCACGACTTCCGGCGGACTGGGTTTAATTTAAACATTTTCCAGGCTACGGAACAGCTCCTAAGGGAAGATTAAGTTGAGAT
AAACAGAGAAGCAAGGCCGAGGAGCCTGCGACCCGGGTCCCTCACTGCCCCAGCGCAGCCCGCGGCGGCCGATGCGCCAGATGCCACCGG
GGCTGTTTAATGTTCGGGGTTATGACCGCAGTGTTTACAAGACGTCTTCGGTTATTTATACTGTTATTCCTCGCAGAGAGCCTTGAAACT
TCCGCTTCATTTGCTCTTTCTTTTCGATTTTTTACCCTTTTTTCTCGGCTTAGTTTGGTACCTGGAGCGAGAGCTTCTCCGCCCTTCCAC
CAACCCCACAGGCCGCTTCGCGGGTGGAGCCCTCTGCCTGGCCATGGAGGAAGGATCCCGCTAGGCTGGTCCCGACTGGAGAAGCTGCTC
TGCCAGGTGTGCTCTCTGTCAGCAATAGTGACCTCATTACCAAGGGGTGGCGACCACATTACCAAGCGCAATTCCCCATTCTCCAAGGGC
TGAGAACTTCGGTGACTTCATCCACCTGTCTATTTGCACATGGAGGACTTTTCAAGATGTCAGGATACCCTTCCATCACCCCACCACCGC
CACCCCAACTTGACTTTCAAGAACACATTTCAAGCTCTGGCCAGAGTCCCGTTCCTCAAATTCATGTGTTCTCTCCTTTCTACCAGAGGG
ATAGAGCCCATGCCTCAACCTATCCAGAGTTCAAATCAAAGAGTCCCCAGTGTGATTCAATTGATTGCCTTTCACGTTTCGCAAATTTTC
CAATCTCCCACTCACGTTTTTACAAAACGAATGCTCTAAATTCTGAGGATTCCAGGCAGGCCATCCATAGAGAAATAACTTTTTCTTGCT
CATTCCCTTACAACCCCAATCTATACATGGATTTTTAGAAAGTCTTCATGGCTATCTATAGTTCCCTACCAATAATTTGAAGCCTTTGCT
TTAGGCAGGAGGCATGTGGCTATGAATAGGGAACACGTAGATTTGACCCTGGTTCTGCATCCAACTAGCTGTTTCTTGAAAGAGCCTGGA
TCCTCAGTTTTCCCATCTCTGCAAGCAGGGATAACGGTAATGAGAATGATAATAATCATTATATGCAGACCTTCCTCTTTCATCTTACAG
AGGCTTAGTGAGGCTCAGATGAGATTATATCTGTAAAATCCCTTGGTAAAGGAAAAGCTCCGTGAAAATGTCAGTTACTTTTACTAAGTG
GCGGGTAGTGAATTATCTGTGCCTAGACCCAAACTGAAAGTGTCTCAGGCAGGAAGTTCCAAGGGATGTATGTTTATAGCATCCAGGCAA
TGATCTTTTTTTTTCCACGAACTAAAATACCTCTTTTTGGTATCTATTGACTCTTTCTCTCTCTCTTTCTGTCTCTCTTTCACCTTGCAC
CTCTCCCTAATGCTCTCTAAATTTGTCCAGAGCTTTCTTTTTCCTAGAAATCCAGAGAGCAAAGTCAGAGCCTGGCACCTGCAGATAGGA
TAACACTGGTGTCTGATGGTGAGGCTGCCCAGTCCCATCAGGAGCCTCAGCCAAGGAGGGGCCTGGGCACACTCAGGTCCCCATGGTTGT
CCATTGAATGGAGTGAGGATCAAGGTGGGAATGACTGGGTGGTGGCTGCCACTAGCCCAGGAACATGACAACGTGACCACACCACACATG
CCTCCAACACACACCCACAGTCTAAACATCTCTCCTTCTCAGTGAGCCCTTCTCCCATTCCAGATCATCAGCACACCCACACCCACCATA
GGTCTCTCTCCTCCGGTCTTCCCAGAAGGGTAAAACTCCCAGCCTACCCTGCTCCAGCTTCAGCCCAGGTAGTTGGTGTGTCTCAATATG
AATAGGGGGTGAGTAGCTTCATAGAAAGAATGGGGAACTCCCTTGGCCTCAAGCCAGTATAGTTTGGAAGTTGGGGGTCGGGGATGTTAA
GGGTGGGGAGTATCCTGCCTGTGACCTCTAGGTTATGAAAACTATCTTAGAAGGTGCTTTTAGAAAGAACCAGGAGAACAACCAAAGCAG
CTTACAGACGCCTGAACGGAGAATGAAGTGTTTCAAGTAAGCGAGTCTGCAAGTTCTCAGAAGCAGACAGATATCCAATCTGGACTGCAG
CCAGGGAAGTCCTCTCTCTCGCTCTCTCTCTCTCTCTCTCTCTCTCTCATTGCTTGTATGACTTCACAAGCAACTCAGGATCATTCTAGC
AGGCTTTCCCACTGTCAAACAGAGACTTCATTCTAAAAAGAGAAGTGATAAACAGAGCTCCAGCTCTGCTAGCTCTATATATTTACTGAT
TAGTGGAAAGCACTGACCAAGGAGACTTTTAAGCCAGTGGTTCTTCAGAATCACCTAGATGCCTCCACCCTCCAGAGATCCTGAGTCCAG
GAGTCTGAAGTGGGGCCCCAGGTGATGTCATTGCTGCTGGTCCCAGGACCACATTTTAACAATCAATGTTTTCAGGTGTCTCATGAGGAA
CACTACTTAATGCAGTGGGAAAGAAAATATTTCAGAGGAGAATTTTTTCTTAAAGAAGCTGCATATTCTGGACTCTAATTTAGTTTAATT
CACTCCAGGATGGCACGCAGGATTCCTAATTCTTAAATGCCATTCAGTCTGGACTTCAAATCACTTGTCTTCAGAAAATAAAAGATTTGT

>64391_64391_5_PEX7-TCF21_PEX7_chr6_137167319_ENST00000541292_TCF21_chr6_134210556_ENST00000367882_length(amino acids)=267AA_BP=95
MSSSPVVAMARCSSGTLPKLQGHCKSIKNTLRRCIVLIGAKPEVNSLWCLAHGIKLSNCGIQLLESLCAPLEAMKVLFIAQSGLPTSLVV
LLQPQDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PEX7-TCF21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PEX7-TCF21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PEX7-TCF21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource