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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARID2-PTPRB (FusionGDB2 ID:6440)

Fusion Gene Summary for ARID2-PTPRB

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID2-PTPRB
Fusion gene ID: 6440
HgeneTgene
Gene symbol

ARID2

PTPRB

Gene ID

196528

5787

Gene nameAT-rich interaction domain 2protein tyrosine phosphatase receptor type B
SynonymsBAF200|CSS6|p200HPTP-BETA|HPTPB|PTPB|R-PTP-BETA|VEPTP
Cytomap

12q12

12q15

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 2ARID domain-containing protein 2AT rich interactive domain 2 (ARID, RFX-like)BRG1-associated factor 200zinc finger protein with activation potentialzipzap/p200receptor-type tyrosine-protein phosphatase betaVE-PTPprotein tyrosine phosphatase, receptor type, beta polypeptidevascular endothelial protein tyrosine phosphatase
Modification date2020032020200327
UniProtAcc

Q68CP9

.
Ensembl transtripts involved in fusion geneENST00000334344, ENST00000422737, 
ENST00000444670, ENST00000457135, 
ENST00000479608, 		ENST00000538174, 
ENST00000551525, ENST00000261266, 
ENST00000334414, ENST00000451516, 
ENST00000538708, ENST00000550358, 
ENST00000550857, 
Fusion gene scores* DoF score17 X 9 X 12=18365 X 6 X 5=150
# samples 175
** MAII scorelog2(17/1836*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARID2 [Title/Abstract] AND PTPRB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID2(46125097)-PTPRB(70933802), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID2

GO:0006337

nucleosome disassembly

8895581

HgeneARID2

GO:0008285

negative regulation of cell proliferation

26169693

HgeneARID2

GO:0030336

negative regulation of cell migration

26169693

TgenePTPRB

GO:0016311

dephosphorylation

19116766|19136612


check buttonFusion gene breakpoints across ARID2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6BE-01AARID2chr12

46125097

-PTPRBchr12

70933802

-
ChimerDB4SARCTCGA-DX-A6BE-01AARID2chr12

46125097

+PTPRBchr12

70933802

-
ChimerDB4SARCTCGA-WK-A8Y0-01AARID2chr12

46125097

+PTPRBchr12

70933802

-


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Fusion Gene ORF analysis for ARID2-PTPRB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334344ENST00000538174ARID2chr12

46125097

+PTPRBchr12

70933802

-
5CDS-intronENST00000334344ENST00000551525ARID2chr12

46125097

+PTPRBchr12

70933802

-
5UTR-3CDSENST00000422737ENST00000261266ARID2chr12

46125097

+PTPRBchr12

70933802

-
5UTR-3CDSENST00000422737ENST00000334414ARID2chr12

46125097

+PTPRBchr12

70933802

-
5UTR-3CDSENST00000422737ENST00000451516ARID2chr12

46125097

+PTPRBchr12

70933802

-
5UTR-3CDSENST00000422737ENST00000538708ARID2chr12

46125097

+PTPRBchr12

70933802

-
5UTR-3CDSENST00000422737ENST00000550358ARID2chr12

46125097

+PTPRBchr12

70933802

-
5UTR-3CDSENST00000422737ENST00000550857ARID2chr12

46125097

+PTPRBchr12

70933802

-
5UTR-intronENST00000422737ENST00000538174ARID2chr12

46125097

+PTPRBchr12

70933802

-
5UTR-intronENST00000422737ENST00000551525ARID2chr12

46125097

+PTPRBchr12

70933802

-
In-frameENST00000334344ENST00000261266ARID2chr12

46125097

+PTPRBchr12

70933802

-
In-frameENST00000334344ENST00000334414ARID2chr12

46125097

+PTPRBchr12

70933802

-
In-frameENST00000334344ENST00000451516ARID2chr12

46125097

+PTPRBchr12

70933802

-
In-frameENST00000334344ENST00000538708ARID2chr12

46125097

+PTPRBchr12

70933802

-
In-frameENST00000334344ENST00000550358ARID2chr12

46125097

+PTPRBchr12

70933802

-
In-frameENST00000334344ENST00000550857ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000444670ENST00000261266ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000444670ENST00000334414ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000444670ENST00000451516ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000444670ENST00000538708ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000444670ENST00000550358ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000444670ENST00000550857ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000457135ENST00000261266ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000457135ENST00000334414ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000457135ENST00000451516ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000457135ENST00000538708ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000457135ENST00000550358ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000457135ENST00000550857ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000479608ENST00000261266ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000479608ENST00000334414ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000479608ENST00000451516ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000479608ENST00000538708ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000479608ENST00000550358ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-3CDSENST00000479608ENST00000550857ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-intronENST00000444670ENST00000538174ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-intronENST00000444670ENST00000551525ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-intronENST00000457135ENST00000538174ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-intronENST00000457135ENST00000551525ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-intronENST00000479608ENST00000538174ARID2chr12

46125097

+PTPRBchr12

70933802

-
intron-intronENST00000479608ENST00000551525ARID2chr12

46125097

+PTPRBchr12

70933802

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334344ARID2chr1246125097+ENST00000451516PTPRBchr1270933802-61494561391509456
ENST00000334344ARID2chr1246125097+ENST00000334414PTPRBchr1270933802-61494561391509456
ENST00000334344ARID2chr1246125097+ENST00000550358PTPRBchr1270933802-16834561391509456
ENST00000334344ARID2chr1246125097+ENST00000538708PTPRBchr1270933802-15964561391509456
ENST00000334344ARID2chr1246125097+ENST00000550857PTPRBchr1270933802-15964561391509456
ENST00000334344ARID2chr1246125097+ENST00000261266PTPRBchr1270933802-15964561391509456

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334344ENST00000451516ARID2chr1246125097+PTPRBchr1270933802-0.0004307430.99956924
ENST00000334344ENST00000334414ARID2chr1246125097+PTPRBchr1270933802-0.0004307430.99956924
ENST00000334344ENST00000550358ARID2chr1246125097+PTPRBchr1270933802-0.001031570.9989685
ENST00000334344ENST00000538708ARID2chr1246125097+PTPRBchr1270933802-0.0016613380.9983386
ENST00000334344ENST00000550857ARID2chr1246125097+PTPRBchr1270933802-0.0016613380.9983386
ENST00000334344ENST00000261266ARID2chr1246125097+PTPRBchr1270933802-0.0016613380.9983386

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Fusion Genomic Features for ARID2-PTPRB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARID2-PTPRB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:46125097/chr12:70933802)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID2

Q68CP9

.
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321703_196316461998.0DomainTyrosine-protein phosphatase
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311703_196315561908.0DomainTyrosine-protein phosphatase
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321904_191016461998.0RegionSubstrate binding
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341904_191018642216.0RegionSubstrate binding
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311904_191015561908.0RegionSubstrate binding
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311643_199715561908.0Topological domainCytoplasmic
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311622_164215561908.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID2chr12:46125097chr12:70933802ENST00000334344+321793_1128941836.0Compositional biasNote=Gln-rich
HgeneARID2chr12:46125097chr12:70933802ENST00000334344+321524_603941836.0DNA bindingRFX-type winged-helix
HgeneARID2chr12:46125097chr12:70933802ENST00000334344+32113_105941836.0DomainARID
HgeneARID2chr12:46125097chr12:70933802ENST00000334344+321313_317941836.0MotifNote=LXXLL
HgeneARID2chr12:46125097chr12:70933802ENST00000334344+3211632_1657941836.0Zinc fingerNote=C2H2-type
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321087_117516461998.0DomainFibronectin type-III 13
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032112_20716461998.0DomainFibronectin type-III 2
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321173_126016461998.0DomainFibronectin type-III 14
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321260_135616461998.0DomainFibronectin type-III 15
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321357_144816461998.0DomainFibronectin type-III 16
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321458_155416461998.0DomainFibronectin type-III 17
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032203_28816461998.0DomainFibronectin type-III 3
TgenePTPRBchr12:46125097chr12:70933802ENST00000261266203223_11116461998.0DomainFibronectin type-III 1
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032291_37816461998.0DomainFibronectin type-III 4
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032379_47116461998.0DomainFibronectin type-III 5
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032467_55216461998.0DomainFibronectin type-III 6
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032556_64116461998.0DomainFibronectin type-III 7
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032642_72916461998.0DomainFibronectin type-III 8
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032730_82916461998.0DomainFibronectin type-III 9
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032819_90616461998.0DomainFibronectin type-III 10
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032909_100116461998.0DomainFibronectin type-III 11
TgenePTPRBchr12:46125097chr12:70933802ENST000002612662032995_108316461998.0DomainFibronectin type-III 12
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341087_117518642216.0DomainFibronectin type-III 13
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234112_20718642216.0DomainFibronectin type-III 2
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341173_126018642216.0DomainFibronectin type-III 14
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341260_135618642216.0DomainFibronectin type-III 15
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341357_144818642216.0DomainFibronectin type-III 16
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341458_155418642216.0DomainFibronectin type-III 17
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341703_196318642216.0DomainTyrosine-protein phosphatase
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234203_28818642216.0DomainFibronectin type-III 3
TgenePTPRBchr12:46125097chr12:70933802ENST00000334414223423_11118642216.0DomainFibronectin type-III 1
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234291_37818642216.0DomainFibronectin type-III 4
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234379_47118642216.0DomainFibronectin type-III 5
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234467_55218642216.0DomainFibronectin type-III 6
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234556_64118642216.0DomainFibronectin type-III 7
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234642_72918642216.0DomainFibronectin type-III 8
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234730_82918642216.0DomainFibronectin type-III 9
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234819_90618642216.0DomainFibronectin type-III 10
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234909_100118642216.0DomainFibronectin type-III 11
TgenePTPRBchr12:46125097chr12:70933802ENST000003344142234995_108318642216.0DomainFibronectin type-III 12
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311087_117515561908.0DomainFibronectin type-III 13
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931112_20715561908.0DomainFibronectin type-III 2
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311173_126015561908.0DomainFibronectin type-III 14
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311260_135615561908.0DomainFibronectin type-III 15
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311357_144815561908.0DomainFibronectin type-III 16
TgenePTPRBchr12:46125097chr12:70933802ENST0000055085719311458_155415561908.0DomainFibronectin type-III 17
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931203_28815561908.0DomainFibronectin type-III 3
TgenePTPRBchr12:46125097chr12:70933802ENST00000550857193123_11115561908.0DomainFibronectin type-III 1
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931291_37815561908.0DomainFibronectin type-III 4
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931379_47115561908.0DomainFibronectin type-III 5
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931467_55215561908.0DomainFibronectin type-III 6
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931556_64115561908.0DomainFibronectin type-III 7
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931642_72915561908.0DomainFibronectin type-III 8
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931730_82915561908.0DomainFibronectin type-III 9
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931819_90615561908.0DomainFibronectin type-III 10
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931909_100115561908.0DomainFibronectin type-III 11
TgenePTPRBchr12:46125097chr12:70933802ENST000005508571931995_108315561908.0DomainFibronectin type-III 12
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321643_199716461998.0Topological domainCytoplasmic
TgenePTPRBchr12:46125097chr12:70933802ENST00000261266203223_162116461998.0Topological domainExtracellular
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341643_199718642216.0Topological domainCytoplasmic
TgenePTPRBchr12:46125097chr12:70933802ENST00000334414223423_162118642216.0Topological domainExtracellular
TgenePTPRBchr12:46125097chr12:70933802ENST00000550857193123_162115561908.0Topological domainExtracellular
TgenePTPRBchr12:46125097chr12:70933802ENST0000026126620321622_164216461998.0TransmembraneHelical
TgenePTPRBchr12:46125097chr12:70933802ENST0000033441422341622_164218642216.0TransmembraneHelical


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Fusion Gene Sequence for ARID2-PTPRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6440_6440_1_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000261266_length(transcript)=1596nt_BP=456nt
GCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACCGCCGGCCCATGACTGAGCCCCGCCGCCGCCGGCCGAGGAATGGGCTCCG
GGCTCTGGTAGGAAGCGCTGGGAGCGGGGGGCGCTTTTAAAACACCGATCTGGGTTTTTTAAAAACCTCCTTTGAAAAAATAATGGCAAA
CTCGACGGGGAAGGCGCCTCCGGACGAGCGGAGAAAGGGACTCGCTTTCCTGGACGAGCTGCGGCAGTTCCACCACAGCAGAGGGTCGCC
TTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTTTAGGCGGATTCGCGAAGGT
TTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCTTTGCTTTAAAACAGTATTA
CTTGCGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGG
TAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAA
GGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAA
TATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGG
CAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGT
TCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCTACTA
TGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGA
TGCACACAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAG
AACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTAT
TGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCA
CATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAA
CCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGAGAATGTACCTGAAGAGCTCC

>6440_6440_1_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000261266_length(amino acids)=456AA_BP=106
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI
ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVK
CDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV
VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRD

--------------------------------------------------------------
>6440_6440_2_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000334414_length(transcript)=6149nt_BP=456nt
GCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACCGCCGGCCCATGACTGAGCCCCGCCGCCGCCGGCCGAGGAATGGGCTCCG
GGCTCTGGTAGGAAGCGCTGGGAGCGGGGGGCGCTTTTAAAACACCGATCTGGGTTTTTTAAAAACCTCCTTTGAAAAAATAATGGCAAA
CTCGACGGGGAAGGCGCCTCCGGACGAGCGGAGAAAGGGACTCGCTTTCCTGGACGAGCTGCGGCAGTTCCACCACAGCAGAGGGTCGCC
TTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTTTAGGCGGATTCGCGAAGGT
TTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCTTTGCTTTAAAACAGTATTA
CTTGCGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGG
TAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAA
GGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAA
TATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGG
CAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGT
TCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCTACTA
TGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGA
TGCACACAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAG
AACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTAT
TGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCA
CATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAA
CCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGAGAATGTACCTGAAGAGCTCC
TGGATAAAAATTATTCACTGTGTGATTTGTTTTTAAAAACTTGCTTCATGCCCTACAGAGGTGCCAGCTATTTCTGTTGATACTATGTAT
AATTTATTAATCTGGAGAATGTTTAAAATTTTATATAATTTAAAGGTAACAGATATTATTGTACATAGTTGTATTTTGTAGTTTCTTCTG
TAAATATGTATTTTTCATAATGTTTAATATTAAGCTTTATATAATACTATTTTTCCACACTAAAGTGTTCATGACTTGTTCTACATAAAA
CTAATTCAACCTGTATGACAGGACTACTGGTAAAATGCATATGGAGGTGGTGGCAGAGACAATCCTTCAGGCCATGTTTTCTACCTGTTT
TGATATTCACTGGACAGGAAAAAGGGCAGGGCTAGAGAGAGCAAATACTATGGCTAGATTTGCTGCATTGCTGTCCCATGAATCTCGAGA
GCCAACAGACATGTCCTAACTTGCTATTAGGACAAATGTGACAGTCAAAAAAAGGATTAGAGGGAGGGAGAAAAAAGAATTAAGCAGTAC
CAAAGCTGAACTAGATGCTTGTGTCTGAACTAGTTGCTCTCTCTCTCCTTTCTCCTTCCAGGGATTCAAGCCAAAGTGGTCAGCTCAGGG
ATCATGTAACTTGCAGTGCAAGCCCAGGATGGTAGGATGCAGGGTTGAGGGTTCTGATAGAGAATGATTCCAAACAGAAGTGATGAATTC
CTTTTGTTAATAAGATGCCAGCTATACCCAGACTGGAAACATAACATGCAAAGCACTATCTACAGTGATTAGAGATCCTTTCATTGCATT
CATGGTGTGGAGTGTGAACATCCACACCCATACTGTAATGTATTTATACACACTAGTTTCTGTCTCATTTTCAGTGGTCTCCATTCCTAG
AAAAGTCACAATTATCCATTCCTACTTGATTTCCCATTAAAAGAATATTATGGTAGCAGATTGTGCCCCTCATTAAAAGGCTTAATGCCA
ACATTTTCATAGAAATGACTACAAACATCATATATAGTAAATTTAAAAACAATAGCAAAAACAAAAACAGTGGTCTTCAGTAAAATTTTC
AAAACTTCTTTTAGTAAATCAATGAAGTCAAAATGTCAAGTAATCACCCAAAGTTGCATTTAATAACAAAAGGCACTACATACTGTACCA
AGTTTATCTTCAATATTTGTGCCTTACTTACTTTGACTATAACAAATTCCAATGAGTCAGAAAGTATTTCCTTCATCAAGGTCCAGTTCC
GACAGCATTCCTGGGAAAAATTTGAAAGGAGTTTGTACGGAATCTTCATAGATACCTGAGAAGATGAGCTGGAGATGTTTGCCTTTTTCA
CACTACAAATTTTTCTGTAATAAACTTGGGAATTAGAGGTCAAGTTTGTTGATGGCATAGCTTCCTTTGCATAAAGAGTATATTTCTTTT
CAAAGTATATATTTTTGTAACCTACCATAAAGTCCGTAAGTGAATACAACGAATGTAATTGACATAATAATTGAAAATCATTGACTATAC
CTAAAATAGTTCTTTATAATTAAATAACTCTACACCCAATCTGGAAATTTTTCCAAGGTTATTTGAAGTTTACAAAAATGTGAAGCATAA
TCATAAGCTTCAAAGATTCACAGTTTCATTGTGCTCAATGCTCTTGTGAAATGACAGTCTTAAGCTCTGATTCTGTATCAAGGAACTAAG
TGAATCTTCTGGAAATGAAAAGGAACAACATATGTGTAAGTGCAGTAGATGTACCACCAGCGAGAAAATAGAGGTCAGAGATCTACAACG
TGTGGCATCCATTAGAAATCACCTTTCCTACATTGAAAAGAAAAAAGAGAAAAAGCAGAATTTTACACTAATGTTGCTTGATGCAAAGCA
CATTAATGCTTGGAAGGATACATTCATTTTCGACTTTTCATTCACTCAGAAAACTTCTAGTAAGTATCTGCAACCTGCTAGGCACTGTTC
CAGAATCTACACATTTCTACTCACATAAAGAGAATCCTCATAAAGTTAGGATTGTTGTTACTACCTTCAATTGAGCTTAAAAGACAGCCT
CATCAAGGGAATGGGATAACTGAGCCAGTCTAGGACAGTGGTCACCTTCCACAGGCCACACACTGGAAAGTGCTAATGCTACTTTAATAG
CAAACCTCTGGATCTAGGAGAGAGAGCAATTAATTGCACAAACCAGGAGTTAAAACCATAAAAAAAACCTATGCATCTGTAATAGTAAAT
AACACTCACGTACTCTGGCAACATCTAGGGTAGTATCAGAATTATGTAAATGGACATGACAGGGAAAAATCGTAGGTTTTTTTAGTCTAA
TCCAACCCAGGAAATGTTTATTCCTACCCTACACCTAATTTTAAACCTTCTTAGCAACAAATATTTCACTATTCGCTCCTACTCCTGGGA
AGACTAAATATATAATTGACTTATTTATTAAATTTAGGAGAAAAAAAAAGTTTTCCTTGACATTCAGCTCTATTGGATTTATTTCCATTT
AATTGCATCATGTGTTATGTCTTGGTAAACACTCCATTTCCTGTCTTGGTGGGCATCCTGTCTGTGTACCTGTGCAGTACACTTTAATCA
TCAAGACTTCAAAGTGCTTTTGAGCTATCAAATCTTGGGAGAGTCCCATCTAGCATCTTAATAATTATTTTTCCAAGTTCGTTATAATTA
ACTCCTTTAACCTCATCTCATTAAATCAATTTTGTATTGTCATTCTGTTGTTCTCTGGAAAGCAGCCAATTGTTCAGCTCTTGAATCAGA
ATTTTCAAAGACTCACCTCTCTTACCTGGGCTTGCACATATTTGTCCTAAGTAATTCTCTATCCCTTAAACCTCTGAGTCCCTCTGTTTT
ATTACTTGCCCCACTCCTCCTACTTGAATATGTTTGTTTTCCCAGTTGAATGTGATTTTTATCTACTGTTCATATTATCTTTTATACCCA
TGAGTATAATTTCATAGTCCTTTCAGGTTCCACATCATCAAAGAGATGACCATAATTTCACTTTTTTTTGAAATGAAGTCTTGCTCTGTT
GCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTACAACCTCCGCCTCCCAGGTTCAAGCGATTCTGCCTTAGCCTCCCAAGTAGC
TGGAATTACAGGTGCCTGCCACCATGTCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGA
ACTCGTGACCTTAGGTGATCCACCCACCTCAACCTCCCAAAGTGCTAGGATTACAAGAGTGAGCCACCGCACCTGGCCAATTCACTTTTA
AATACTAAAAGGCACACAGCACACAGACATTTTCGGGGCAGTTTTCTTTGGGAGGGTCTTTGATAAATTTTGTAATCACCTCTCGGAAGA
AAGCCCAAAATGACATGTGAAAATAATATTAAACCATTTACCAGATGTCCAGCAATATAAAAATAGACCTCACATGCTACCCTTCACATG
CTGATTCTCTTGCCTTGCTGTTTAAGGATCCAGTTTCTTATGTTAAACATTTTCCTTACCTTTTGCAATAATATTATTGGCCATATACTA
AATTCTCATTCACTTAGCTTTCTAAGAATTCTTTGAGGTTGGAATCCTGAAATCATAAAGCTACCAGATCTGCACAACAGCAGTGGTAGT
ATCTGAGCCCAAACTCTGAGACGCTCTAGAGTTTTAGTTTACAAACATGAGCCAGACCAAACCTGACCTGGTGAAAATCAATAGGTAATA
AACTGCTTGTATATGATAGCAGTTCAAGGGCTTTCTGGGTTCCATTTCACTGAGGAAATGAAAATATAACTGATTAGCCAAGACAGAGTG
GCAATAAGGAATAACTGATCCTCCTCCAAGTTGCAGTGAGCAAGCCCTCAAGCCTACCTCATTCCTGAAGAGTTGAAGGAGAAAATGCCG
TGCTAATTTTCTGCCCTGCTATTTTTAACCTGAAATTTAGAATTACATCAGGTATTCAAAGAATGTTCCCTATCAAAGGAAAATCTGTAA
ACGATGACTGCAAAAAGCAAGTGAAATGATGCAAAGAGAAAATATTTGCAAAACAGAATCTAACCAGACATCATCATGAAGATAAAATGG
CATCTCTTCTGTGTGGCCTGGGTGTGCTTGGACAATCCTGTCACACGTTTCTATTAGGACATGTTGCCCTTTTGAGGATTCACTCTATGT
TGGCCAGATGGTTTAACTGATTAAACAATTGAATCAATTTATTTTGCTTTTTGAATTGACCAGATATTTAACTAAATGTACTGGGTTTGG
CATTTTAGACACACTGCCTTAGATTCTTGTAGTGCATGATGACTTTGAAAATGTTTGGCCATTTTAGTTAAAATGCAGGGTAACATTTGA
TGCAGCCATGATAACAGGAAAAATCTGTTCTGTTCTAAAAATGTTTCTAGCAATAGAAGTATTTCTGGCTAAGAGAATACTCTTGACTTG
TAGGGAGGCTCCCTCGGAATAAATGTATGCAACACAAATAAGGCATTTTATTTTTTAAAAGATTGTCTATATAAGATACACTTATTAAAT

>6440_6440_2_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000334414_length(amino acids)=456AA_BP=106
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI
ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVK
CDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV
VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRD

--------------------------------------------------------------
>6440_6440_3_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000451516_length(transcript)=6149nt_BP=456nt
GCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACCGCCGGCCCATGACTGAGCCCCGCCGCCGCCGGCCGAGGAATGGGCTCCG
GGCTCTGGTAGGAAGCGCTGGGAGCGGGGGGCGCTTTTAAAACACCGATCTGGGTTTTTTAAAAACCTCCTTTGAAAAAATAATGGCAAA
CTCGACGGGGAAGGCGCCTCCGGACGAGCGGAGAAAGGGACTCGCTTTCCTGGACGAGCTGCGGCAGTTCCACCACAGCAGAGGGTCGCC
TTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTTTAGGCGGATTCGCGAAGGT
TTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCTTTGCTTTAAAACAGTATTA
CTTGCGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGG
TAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAA
GGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAA
TATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGG
CAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGT
TCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCTACTA
TGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGA
TGCACACAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAG
AACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTAT
TGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCA
CATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAA
CCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGAGAATGTACCTGAAGAGCTCC
TGGATAAAAATTATTCACTGTGTGATTTGTTTTTAAAAACTTGCTTCATGCCCTACAGAGGTGCCAGCTATTTCTGTTGATACTATGTAT
AATTTATTAATCTGGAGAATGTTTAAAATTTTATATAATTTAAAGGTAACAGATATTATTGTACATAGTTGTATTTTGTAGTTTCTTCTG
TAAATATGTATTTTTCATAATGTTTAATATTAAGCTTTATATAATACTATTTTTCCACACTAAAGTGTTCATGACTTGTTCTACATAAAA
CTAATTCAACCTGTATGACAGGACTACTGGTAAAATGCATATGGAGGTGGTGGCAGAGACAATCCTTCAGGCCATGTTTTCTACCTGTTT
TGATATTCACTGGACAGGAAAAAGGGCAGGGCTAGAGAGAGCAAATACTATGGCTAGATTTGCTGCATTGCTGTCCCATGAATCTCGAGA
GCCAACAGACATGTCCTAACTTGCTATTAGGACAAATGTGACAGTCAAAAAAAGGATTAGAGGGAGGGAGAAAAAAGAATTAAGCAGTAC
CAAAGCTGAACTAGATGCTTGTGTCTGAACTAGTTGCTCTCTCTCTCCTTTCTCCTTCCAGGGATTCAAGCCAAAGTGGTCAGCTCAGGG
ATCATGTAACTTGCAGTGCAAGCCCAGGATGGTAGGATGCAGGGTTGAGGGTTCTGATAGAGAATGATTCCAAACAGAAGTGATGAATTC
CTTTTGTTAATAAGATGCCAGCTATACCCAGACTGGAAACATAACATGCAAAGCACTATCTACAGTGATTAGAGATCCTTTCATTGCATT
CATGGTGTGGAGTGTGAACATCCACACCCATACTGTAATGTATTTATACACACTAGTTTCTGTCTCATTTTCAGTGGTCTCCATTCCTAG
AAAAGTCACAATTATCCATTCCTACTTGATTTCCCATTAAAAGAATATTATGGTAGCAGATTGTGCCCCTCATTAAAAGGCTTAATGCCA
ACATTTTCATAGAAATGACTACAAACATCATATATAGTAAATTTAAAAACAATAGCAAAAACAAAAACAGTGGTCTTCAGTAAAATTTTC
AAAACTTCTTTTAGTAAATCAATGAAGTCAAAATGTCAAGTAATCACCCAAAGTTGCATTTAATAACAAAAGGCACTACATACTGTACCA
AGTTTATCTTCAATATTTGTGCCTTACTTACTTTGACTATAACAAATTCCAATGAGTCAGAAAGTATTTCCTTCATCAAGGTCCAGTTCC
GACAGCATTCCTGGGAAAAATTTGAAAGGAGTTTGTACGGAATCTTCATAGATACCTGAGAAGATGAGCTGGAGATGTTTGCCTTTTTCA
CACTACAAATTTTTCTGTAATAAACTTGGGAATTAGAGGTCAAGTTTGTTGATGGCATAGCTTCCTTTGCATAAAGAGTATATTTCTTTT
CAAAGTATATATTTTTGTAACCTACCATAAAGTCCGTAAGTGAATACAACGAATGTAATTGACATAATAATTGAAAATCATTGACTATAC
CTAAAATAGTTCTTTATAATTAAATAACTCTACACCCAATCTGGAAATTTTTCCAAGGTTATTTGAAGTTTACAAAAATGTGAAGCATAA
TCATAAGCTTCAAAGATTCACAGTTTCATTGTGCTCAATGCTCTTGTGAAATGACAGTCTTAAGCTCTGATTCTGTATCAAGGAACTAAG
TGAATCTTCTGGAAATGAAAAGGAACAACATATGTGTAAGTGCAGTAGATGTACCACCAGCGAGAAAATAGAGGTCAGAGATCTACAACG
TGTGGCATCCATTAGAAATCACCTTTCCTACATTGAAAAGAAAAAAGAGAAAAAGCAGAATTTTACACTAATGTTGCTTGATGCAAAGCA
CATTAATGCTTGGAAGGATACATTCATTTTCGACTTTTCATTCACTCAGAAAACTTCTAGTAAGTATCTGCAACCTGCTAGGCACTGTTC
CAGAATCTACACATTTCTACTCACATAAAGAGAATCCTCATAAAGTTAGGATTGTTGTTACTACCTTCAATTGAGCTTAAAAGACAGCCT
CATCAAGGGAATGGGATAACTGAGCCAGTCTAGGACAGTGGTCACCTTCCACAGGCCACACACTGGAAAGTGCTAATGCTACTTTAATAG
CAAACCTCTGGATCTAGGAGAGAGAGCAATTAATTGCACAAACCAGGAGTTAAAACCATAAAAAAAACCTATGCATCTGTAATAGTAAAT
AACACTCACGTACTCTGGCAACATCTAGGGTAGTATCAGAATTATGTAAATGGACATGACAGGGAAAAATCGTAGGTTTTTTTAGTCTAA
TCCAACCCAGGAAATGTTTATTCCTACCCTACACCTAATTTTAAACCTTCTTAGCAACAAATATTTCACTATTCGCTCCTACTCCTGGGA
AGACTAAATATATAATTGACTTATTTATTAAATTTAGGAGAAAAAAAAAGTTTTCCTTGACATTCAGCTCTATTGGATTTATTTCCATTT
AATTGCATCATGTGTTATGTCTTGGTAAACACTCCATTTCCTGTCTTGGTGGGCATCCTGTCTGTGTACCTGTGCAGTACACTTTAATCA
TCAAGACTTCAAAGTGCTTTTGAGCTATCAAATCTTGGGAGAGTCCCATCTAGCATCTTAATAATTATTTTTCCAAGTTCGTTATAATTA
ACTCCTTTAACCTCATCTCATTAAATCAATTTTGTATTGTCATTCTGTTGTTCTCTGGAAAGCAGCCAATTGTTCAGCTCTTGAATCAGA
ATTTTCAAAGACTCACCTCTCTTACCTGGGCTTGCACATATTTGTCCTAAGTAATTCTCTATCCCTTAAACCTCTGAGTCCCTCTGTTTT
ATTACTTGCCCCACTCCTCCTACTTGAATATGTTTGTTTTCCCAGTTGAATGTGATTTTTATCTACTGTTCATATTATCTTTTATACCCA
TGAGTATAATTTCATAGTCCTTTCAGGTTCCACATCATCAAAGAGATGACCATAATTTCACTTTTTTTTGAAATGAAGTCTTGCTCTGTT
GCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTACAACCTCCGCCTCCCAGGTTCAAGCGATTCTGCCTTAGCCTCCCAAGTAGC
TGGAATTACAGGTGCCTGCCACCATGTCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGA
ACTCGTGACCTTAGGTGATCCACCCACCTCAACCTCCCAAAGTGCTAGGATTACAAGAGTGAGCCACCGCACCTGGCCAATTCACTTTTA
AATACTAAAAGGCACACAGCACACAGACATTTTCGGGGCAGTTTTCTTTGGGAGGGTCTTTGATAAATTTTGTAATCACCTCTCGGAAGA
AAGCCCAAAATGACATGTGAAAATAATATTAAACCATTTACCAGATGTCCAGCAATATAAAAATAGACCTCACATGCTACCCTTCACATG
CTGATTCTCTTGCCTTGCTGTTTAAGGATCCAGTTTCTTATGTTAAACATTTTCCTTACCTTTTGCAATAATATTATTGGCCATATACTA
AATTCTCATTCACTTAGCTTTCTAAGAATTCTTTGAGGTTGGAATCCTGAAATCATAAAGCTACCAGATCTGCACAACAGCAGTGGTAGT
ATCTGAGCCCAAACTCTGAGACGCTCTAGAGTTTTAGTTTACAAACATGAGCCAGACCAAACCTGACCTGGTGAAAATCAATAGGTAATA
AACTGCTTGTATATGATAGCAGTTCAAGGGCTTTCTGGGTTCCATTTCACTGAGGAAATGAAAATATAACTGATTAGCCAAGACAGAGTG
GCAATAAGGAATAACTGATCCTCCTCCAAGTTGCAGTGAGCAAGCCCTCAAGCCTACCTCATTCCTGAAGAGTTGAAGGAGAAAATGCCG
TGCTAATTTTCTGCCCTGCTATTTTTAACCTGAAATTTAGAATTACATCAGGTATTCAAAGAATGTTCCCTATCAAAGGAAAATCTGTAA
ACGATGACTGCAAAAAGCAAGTGAAATGATGCAAAGAGAAAATATTTGCAAAACAGAATCTAACCAGACATCATCATGAAGATAAAATGG
CATCTCTTCTGTGTGGCCTGGGTGTGCTTGGACAATCCTGTCACACGTTTCTATTAGGACATGTTGCCCTTTTGAGGATTCACTCTATGT
TGGCCAGATGGTTTAACTGATTAAACAATTGAATCAATTTATTTTGCTTTTTGAATTGACCAGATATTTAACTAAATGTACTGGGTTTGG
CATTTTAGACACACTGCCTTAGATTCTTGTAGTGCATGATGACTTTGAAAATGTTTGGCCATTTTAGTTAAAATGCAGGGTAACATTTGA
TGCAGCCATGATAACAGGAAAAATCTGTTCTGTTCTAAAAATGTTTCTAGCAATAGAAGTATTTCTGGCTAAGAGAATACTCTTGACTTG
TAGGGAGGCTCCCTCGGAATAAATGTATGCAACACAAATAAGGCATTTTATTTTTTAAAAGATTGTCTATATAAGATACACTTATTAAAT

>6440_6440_3_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000451516_length(amino acids)=456AA_BP=106
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI
ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVK
CDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV
VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRD

--------------------------------------------------------------
>6440_6440_4_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000538708_length(transcript)=1596nt_BP=456nt
GCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACCGCCGGCCCATGACTGAGCCCCGCCGCCGCCGGCCGAGGAATGGGCTCCG
GGCTCTGGTAGGAAGCGCTGGGAGCGGGGGGCGCTTTTAAAACACCGATCTGGGTTTTTTAAAAACCTCCTTTGAAAAAATAATGGCAAA
CTCGACGGGGAAGGCGCCTCCGGACGAGCGGAGAAAGGGACTCGCTTTCCTGGACGAGCTGCGGCAGTTCCACCACAGCAGAGGGTCGCC
TTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTTTAGGCGGATTCGCGAAGGT
TTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCTTTGCTTTAAAACAGTATTA
CTTGCGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGG
TAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAA
GGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAA
TATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGG
CAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGT
TCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCTACTA
TGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGA
TGCACACAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAG
AACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTAT
TGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCA
CATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAA
CCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGAGAATGTACCTGAAGAGCTCC

>6440_6440_4_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000538708_length(amino acids)=456AA_BP=106
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI
ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVK
CDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV
VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRD

--------------------------------------------------------------
>6440_6440_5_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000550358_length(transcript)=1683nt_BP=456nt
GCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACCGCCGGCCCATGACTGAGCCCCGCCGCCGCCGGCCGAGGAATGGGCTCCG
GGCTCTGGTAGGAAGCGCTGGGAGCGGGGGGCGCTTTTAAAACACCGATCTGGGTTTTTTAAAAACCTCCTTTGAAAAAATAATGGCAAA
CTCGACGGGGAAGGCGCCTCCGGACGAGCGGAGAAAGGGACTCGCTTTCCTGGACGAGCTGCGGCAGTTCCACCACAGCAGAGGGTCGCC
TTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTTTAGGCGGATTCGCGAAGGT
TTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCTTTGCTTTAAAACAGTATTA
CTTGCGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGG
TAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAA
GGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAA
TATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGG
CAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGT
TCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCTACTA
TGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGA
TGCACACAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAG
AACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTAT
TGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCA
CATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAA
CCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGAGAATGTACCTGAAGAGCTCC
TGGATAAAAATTATTCACTGTGTGATTTGTTTTTAAAAACTTGCTTCATGCCCTACAGAGGTGCCAGCTATTTCTGTTGATACTATGTAT

>6440_6440_5_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000550358_length(amino acids)=456AA_BP=106
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI
ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVK
CDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV
VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRD

--------------------------------------------------------------
>6440_6440_6_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000550857_length(transcript)=1596nt_BP=456nt
GCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACCGCCGGCCCATGACTGAGCCCCGCCGCCGCCGGCCGAGGAATGGGCTCCG
GGCTCTGGTAGGAAGCGCTGGGAGCGGGGGGCGCTTTTAAAACACCGATCTGGGTTTTTTAAAAACCTCCTTTGAAAAAATAATGGCAAA
CTCGACGGGGAAGGCGCCTCCGGACGAGCGGAGAAAGGGACTCGCTTTCCTGGACGAGCTGCGGCAGTTCCACCACAGCAGAGGGTCGCC
TTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTTTAGGCGGATTCGCGAAGGT
TTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCTTTGCTTTAAAACAGTATTA
CTTGCGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGG
TAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAA
GGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAA
TATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGG
CAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGT
TCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGATCATTACTGGCCAGCGGACCAGGATTCCCTCTACTA
TGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGA
TGCACACAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAG
AACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTAT
TGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCA
CATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAA
CCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGAGAATGTACCTGAAGAGCTCC

>6440_6440_6_ARID2-PTPRB_ARID2_chr12_46125097_ENST00000334344_PTPRB_chr12_70933802_ENST00000550857_length(amino acids)=456AA_BP=106
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI
ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVK
CDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV
VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARID2-PTPRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARID2-PTPRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARID2-PTPRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource