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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PFDN6-CREBRF (FusionGDB2 ID:64417)

Fusion Gene Summary for PFDN6-CREBRF

Fusion gene summary

Fusion gene information	Fusion gene name: PFDN6-CREBRF
	Fusion gene ID: 64417
		Hgene	Tgene
	Gene symbol	PFDN6	CREBRF
	Gene ID	10471	153222
	Gene name	prefoldin subunit 6	CREB3 regulatory factor
	Synonyms	H2-KE2\|HKE2\|KE-2\|PFD6	C5orf41\|LRF
	Cytomap	6p21.32	5q35.1
	Type of gene	protein-coding	protein-coding
	Description	prefoldin subunit 6HLA class II region expressed gene KE2KE2 protein	CREB3 regulatory factorUPF0474 protein C5orf41adult retina proteinluman recruitment factorluman-recruiting factorluman/CREB3 recruitment factor
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IUR6
	Ensembl transtripts involved in fusion gene	ENST00000374606, ENST00000395131, ENST00000374607, ENST00000374610, ENST00000383207, ENST00000399383, ENST00000399385, ENST00000412289, ENST00000425878, ENST00000431830, ENST00000432391, ENST00000442285, ENST00000445559, ENST00000448594, ENST00000451970, ENST00000452658, ENST00000463584, ENST00000468094, ENST00000474406, ENST00000482292, ENST00000491095, ENST00000547641, ENST00000547952, ENST00000548040, ENST00000552711,	ENST00000296953, ENST00000517882, ENST00000520420, ENST00000522692, ENST00000540014,
Fusion gene scores	* DoF score	4 X 4 X 1=16	8 X 8 X 2=128
	# samples	4	8
	** MAII score	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PFDN6 [Title/Abstract] AND CREBRF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PFDN6(33258706)-CREBRF(172559741), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PFDN6	GO:0051131	chaperone-mediated protein complex assembly	9630229
Tgene	CREBRF	GO:0045944	positive regulation of transcription by RNA polymerase II	16940180

Fusion gene breakpoints across PFDN6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CREBRF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BG033635	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-

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Fusion Gene ORF analysis for PFDN6-CREBRF

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000374606	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000374606	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000374606	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000374606	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000374606	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000395131	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000395131	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000395131	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000395131	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
5CDS-intron	ENST00000395131	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374607	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374607	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374607	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374607	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374607	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374610	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374610	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374610	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374610	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000374610	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000383207	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000383207	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000383207	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000383207	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000383207	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399383	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399383	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399383	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399383	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399383	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399385	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399385	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399385	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399385	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000399385	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000412289	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000412289	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000412289	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000412289	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000412289	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000425878	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000425878	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000425878	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000425878	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000425878	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000431830	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000431830	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000431830	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000431830	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000431830	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000432391	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000432391	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000432391	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000432391	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000432391	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000442285	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000442285	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000442285	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000442285	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000442285	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000445559	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000445559	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000445559	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000445559	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000445559	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000448594	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000448594	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000448594	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000448594	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000448594	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000451970	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000451970	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000451970	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000451970	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000451970	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000452658	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000452658	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000452658	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000452658	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000452658	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000463584	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000463584	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000463584	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000463584	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000463584	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000468094	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000468094	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000468094	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000468094	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000468094	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000474406	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000474406	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000474406	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000474406	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000474406	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000482292	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000482292	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000482292	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000482292	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000482292	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000491095	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000491095	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000491095	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000491095	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000491095	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547641	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547641	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547641	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547641	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547641	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547952	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547952	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547952	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547952	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000547952	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000548040	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000548040	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000548040	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000548040	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000548040	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000552711	ENST00000296953	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000552711	ENST00000517882	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000552711	ENST00000520420	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000552711	ENST00000522692	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-
intron-intron	ENST00000552711	ENST00000540014	PFDN6	chr6	33258706	+	CREBRF	chr5	172559741	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PFDN6-CREBRF

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PFDN6-CREBRF

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33258706/:172559741)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CREBRF Q8IUR6
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. {ECO:0000269\|PubMed:18391022}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PFDN6-CREBRF

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PFDN6-CREBRF

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PFDN6-CREBRF

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PFDN6-CREBRF

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source