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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARID3A-PMEPA1 (FusionGDB2 ID:6449)

Fusion Gene Summary for ARID3A-PMEPA1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID3A-PMEPA1
Fusion gene ID: 6449
HgeneTgene
Gene symbol

ARID3A

PMEPA1

Gene ID

1820

56937

Gene nameAT-rich interaction domain 3Aprostate transmembrane protein, androgen induced 1
SynonymsBRIGHT|DRIL1|DRIL3|E2FBP1STAG1|TMEPAI
Cytomap

19p13.3

20q13.31

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 3AARID domain-containing 3AARID domain-containing protein 3AAT rich interactive domain 3A (BRIGHT- like) proteinAT rich interactive domain 3A (BRIGHT-like)B-cell regulator of IgH transcriptionE2F-bindingprotein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNA
Modification date2020031320200313
UniProtAcc

Q99856

.
Ensembl transtripts involved in fusion geneENST00000263620, ENST00000592216, 
ENST00000265626, ENST00000347215, 
ENST00000395814, ENST00000395816, 
ENST00000472841, ENST00000341744, 
Fusion gene scores* DoF score7 X 6 X 6=2528 X 5 X 5=200
# samples 88
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARID3A [Title/Abstract] AND PMEPA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID3A(968503)-PMEPA1(56234753), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePMEPA1

GO:0010991

negative regulation of SMAD protein complex assembly

20129061

TgenePMEPA1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

24627487

TgenePMEPA1

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

24627487


check buttonFusion gene breakpoints across ARID3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PMEPA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0AU-01AARID3Achr19

968503

-PMEPA1chr20

56234753

-
ChimerDB4BRCATCGA-BH-A0AU-01AARID3Achr19

968503

+PMEPA1chr20

56234753

-
ChimerDB4BRCATCGA-BH-A0AUARID3Achr19

968503

+PMEPA1chr20

56234753

-


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Fusion Gene ORF analysis for ARID3A-PMEPA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263620ENST00000265626ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000347215ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000395814ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000395816ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000472841ARID3Achr19

968503

+PMEPA1chr20

56234753

-
In-frameENST00000263620ENST00000341744ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-3CDSENST00000592216ENST00000341744ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000265626ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000347215ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000395814ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000395816ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000472841ARID3Achr19

968503

+PMEPA1chr20

56234753

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263620ARID3Achr19968503+ENST00000341744PMEPA1chr2056234753-633719211862675829

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263620ENST00000341744ARID3Achr19968503+PMEPA1chr2056234753-0.0019075630.9980925

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Fusion Genomic Features for ARID3A-PMEPA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARID3A-PMEPA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:968503/chr20:56234753)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID3A

Q99856

.
FUNCTION: Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89424_445531594.0Compositional biasNote=Ala-rich
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+8967_70531594.0Compositional biasNote=Poly-Ala
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+8989_157531594.0Compositional biasNote=Glu-rich
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89238_330531594.0DomainARID
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89119_156531594.0RegionNote=Acidic
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89445_488531594.0RegionImportant for nuclear localization
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89490_513531594.0RegionNote=Homodimerization
TgenePMEPA1chr19:968503chr20:56234753ENST0000026562604158_1610238.0MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST0000026562604229_2320238.0MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST0000034174404158_16136288.0MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST0000034174404229_23236288.0MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST0000034721504158_1611253.0MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST0000034721504229_2321253.0MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST0000039581404158_1610238.0MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST0000039581404229_2320238.0MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST0000039581604158_1610238.0MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST0000039581604229_2320238.0MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST00000265626041_400238.0Topological domainLumenal
TgenePMEPA1chr19:968503chr20:56234753ENST000002656260464_2870238.0Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST000003417440464_28736288.0Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST00000347215041_401253.0Topological domainLumenal
TgenePMEPA1chr19:968503chr20:56234753ENST000003472150464_2871253.0Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST00000395814041_400238.0Topological domainLumenal
TgenePMEPA1chr19:968503chr20:56234753ENST000003958140464_2870238.0Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST00000395816041_400238.0Topological domainLumenal
TgenePMEPA1chr19:968503chr20:56234753ENST000003958160464_2870238.0Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST000002656260441_630238.0TransmembraneHelical
TgenePMEPA1chr19:968503chr20:56234753ENST000003417440441_6336288.0TransmembraneHelical
TgenePMEPA1chr19:968503chr20:56234753ENST000003472150441_631253.0TransmembraneHelical
TgenePMEPA1chr19:968503chr20:56234753ENST000003958140441_630238.0TransmembraneHelical
TgenePMEPA1chr19:968503chr20:56234753ENST000003958160441_630238.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89550_579531594.0Compositional biasNote=Gly-rich
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89444_541531594.0DomainREKLES
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89537_557531594.0RegionImportant for cytoplasmic localization
TgenePMEPA1chr19:968503chr20:56234753ENST00000341744041_4036288.0Topological domainLumenal


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Fusion Gene Sequence for ARID3A-PMEPA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6449_6449_1_ARID3A-PMEPA1_ARID3A_chr19_968503_ENST00000263620_PMEPA1_chr20_56234753_ENST00000341744_length(transcript)=6337nt_BP=1921nt
GCGGGGCGCCTCTTACCAATCGGGCGGAGGGGTGTAGACGCGGACGCGGCTGGCGGCTCGGTTTCTGCAAATGCGTGAATGAGCCGGATG
CCAGCCTCTGTCCCCTGGAGCCCAGCGTGAGGAAGAGGCATGCCCCATCAGCCTTCAGCTTGAGCCCGGCGGCCCCCGCCCCCGCCCCCT
GCCACCCTGCACTGCCCCGGCTCCCCCGCGGCCCCCACGCTGCAGTGCGGCCGGGCCCCCTCCCCGCAGGGGCCGCCCCCGCCGCCCACC
CCTAGCGCCCGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGCCCGGGCCGCAGGGCCATGAAACTACAGGCCGTGATGGAGACGCTGTTG
CAGCGGCAGCAGCGGGCGCGCCAGGAGCTGGAGGCCCGGCAGCAGCTGCCCCCCGATCCCCCTGCTGCACCCCCCGGCCGGGCCCGGGCT
GCCCCCGACGAGGACAGAGAGCCCGAGAGTGCCCGGATGCAGCGGGCTCAGATGGCCGCACTGGCAGCCATGCGGGCTGCAGCTGCGGGC
CTGGGACACCCAGCCAGCCCCGGCGGCTCTGAGGATGGGCCCCCAGGCTCGGAGGAGGAGGACGCGGCCCGGGAGGGGACACCGGGCTCA
CCCGGGCGAGGCAGAGAAGGGCCAGGAGAGGAGCACTTTGAGGACATGGCCTCCGACGAGGACATGAAGCCCAAATGGGAGGAGGAGGAG
ATGGAGGAAGACCTCGGGGAGGATGAGGAGGAGGAGGAGGAGGATTACGAGGATGAGGAGGAGGAGGAGGACGAGGAGGGGCTGGGCCCC
CCAGGCCCTGCCAGCTTGGGCACCACGGCACTGTTCCCCCGAAAGGCCCAGCCACCCCAGGCCTTCCGCGGCGATGGCGTTCCCAGGGTG
CTGGGGGGCCAGGAGCGGCCGGGGCCTGGCCCTGCCCACCCCGGAGGGGCCGCCCACGTAGCCCCGCAGCTGCAGCCGCCTGACCACGGC
GACTGGACTTACGAGGAGCAGTTTAAGCAGCTCTACGAACTCGACGGGGACCCCAAGAGGAAGGAATTCCTGGATGACTTGTTCAGCTTC
ATGCAGAAGCGAGGGACACCTGTGAACCGCATCCCCATCATGGCCAAACAGGTCCTTGACCTGTTCATGCTGTACGTGCTGGTGACGGAG
AAGGGCGGCCTCGTGGAGGTCATCAACAAGAAGCTGTGGCGTGAGATCACCAAGGGCCTCAACCTGCCCACGTCCATCACCAGTGCAGCC
TTCACCCTGCGGACCCAATACATGAAGTACCTGTACCCCTACGAGTGTGAGAAGCGGGGCCTCAGTAACCCCAATGAGCTCCAGGCAGCC
ATAGACAGCAACCGACGGGAGGGCCGGCGCCAGAGCTTTGGTGGCTCCCTCTTTGCCTACTCGCCAGGCGGGGCACACGGCATGCTCTCC
TCACCCAAGCTACCCGTGTCCTCCCTGGGCCTGGCCGCAAGCACCAATGGCAGCTCCATCACCCCCGCCCCTAAGATCAAGAAAGAGGAG
GACTCAGCCATCCCCATCACAGTCCCTGGCCGCCTGCCTGTGTCCCTGGCGGGCCACCCTGTGGTGGCAGCCCAGGCAGCAGCTGTGCAA
GCAGCAGCCGCCCAAGCAGCTGTGGCCGCACAGGCAGCTGCCCTGGAACAGCTGCGGGAGAAGCTGGAGTCTGCAGAGCCTCCGGAGAAG
AAGATGGCCCTGGTGGCCGATGAGCAGCAACGGCTGATGCAACGTGCACTCCAGCAGAACTTCCTGGCCATGGCGGCCCAGCTGCCCATG
AGCATTCGGATCAACAGCCAAGCCTCCGAAAGCCGCCAGGACTCTGCTGTGAACCTGACGGGCACCAACGGCAGCAACAGCATCAGCATG
TCGGTGGAGATCAACGGCATCATGTACACAGCGGAGCTGGAGTTTGTTCAGATCATCATCATCGTGGTGGTGATGATGGTGATGGTGGTG
GTGATCACGTGCCTGCTGAGCCACTACAAGCTGTCTGCACGGTCCTTCATCAGCCGGCACAGCCAGGGGCGGAGGAGAGAAGATGCCCTG
TCCTCAGAAGGATGCCTGTGGCCCTCGGAGAGCACAGTGTCAGGCAACGGAATCCCAGAGCCGCAGGTCTACGCCCCGCCTCGGCCCACC
GACCGCCTGGCCGTGCCGCCCTTCGCCCAGCGGGAGCGCTTCCACCGCTTCCAGCCCACCTATCCGTACCTGCAGCACGAGATCGACCTG
CCACCCACCATCTCGCTGTCAGACGGGGAGGAGCCCCCACCCTACCAGGGCCCCTGCACCCTCCAGCTTCGGGACCCCGAGCAGCAGCTG
GAACTGAACCGGGAGTCGGTGCGCGCACCCCCAAACAGAACCATCTTCGACAGTGACCTGATGGATAGTGCCAGGCTGGGCGGCCCCTGC
CCCCCCAGCAGTAACTCGGGCATCAGCGCCACGTGCTACGGCAGCGGCGGGCGCATGGAGGGGCCGCCGCCCACCTACAGCGAGGTCATC
GGCCACTACCCGGGGTCCTCCTTCCAGCACCAGCAGAGCAGTGGGCCGCCCTCCTTGCTGGAGGGGACCCGGCTCCACCACACACACATC
GCGCCCCTAGAGAGCGCAGCCATCTGGAGCAAAGAGAAGGATAAACAGAAAGGACACCCTCTCTAGGGTCCCCAGGGGGGCCGGGCTGGG
GCTGCGTAGGTGAAAAGGCAGAACACTCCGCGCTTCTTAGAAGAGGAGTGAGAGGAAGGCGGGGGGCGCAGCAACGCATCGTGTGGCCCT
CCCCTCCCACCTCCCTGTGTATAAATATTTACATGTGATGTCTGGTCTGAATGCACAAGCTAAGAGAGCTTGCAAAAAAAAAAAGAAAAA
AGAAAAAAAAAAACCACGTTTCTTTGTTGAGCTGTGTCTTGAAGGCAAAAGAAAAAAAATTTCTACAGTAGTCTTTCTTGTTTCTAGTTG
AGCTGCGTGCGTGAATGCTTATTTTCTTTTGTTTATGATAATTTCACTTAACTTTAAAGACATATTTGCACAAAACCTTTGTTTAAAGAT
CTGCAATATTATATATATAAATATATATAAGATAAGAGAAACTGTATGTGCGAGGGCAGGAGTATTTTTGTATTAGAAGAGGCCTATTAA
AAAAAAAAGTTGTTTTCTGAACTAGAAGAGGAAAAAAATGGCAATTTTTGAGTGCCAAGTCAGAAAGTGTGTATTACCTTGTAAAGAAAA
AAATTACAAAGCAGGGGTTTAGAGTTATTTATATAAATGTTGAGATTTTGCACTATTTTTTAATATAAATATGTCAGTGCTTGCTTGATG
GAAACTTCTCTTGTGTCTGTTGAGACTTTAAGGGAGAAATGTCGGAATTTCAGAGTCGCCTGACGGCAGAGGGTGAGCCCCCGTGGAGTC
TGCAGAGAGGCCTTGGCCAGGAGCGGCGGGCTTTCCCGAGGGGCCACTGTCCCTGCAGAGTGGATGCTTCTGCCTAGTGACAGGTTATCA
CCACGTTATATATTCCCTACCGAAGGAGACACCTTTTCCCCCCTGACCCAGAACAGCCTTTAAATCACAAGCAAAATAGGAAAGTTAACC
ACGGAGGCACCGAGTTCCAGGTAGTGGTTTTGCCTTTCCCAAAAATGAAAATAAACTGTTACCGAAGGAATTAGTTTTTCCTCTTCTTTT
TTCCAACTGTGAAGGTCCCCGTGGGGTGGAGCATGGTGCCCCTCACAAGCCGCAGCGGCTGGTGCCCGGGCTACCAGGGACATGCCAGAG
GGCTCGATGACTTGTCTCTGCAGGGCGCTTTGGTGGTTGTTCAGCTGGCTAAAGGTTCACCGGTGAAGGCAGGTGCGGTAACTGCCGCAC
TGGACCCTAGGAAGCCCCAGGTATTCGCAATCTGACCTCCTCCTGTCTGTTTCCCTTCACGGATCAATTCTCACTTAAGAGGCCAATAAA
CAACCCAACATGAAAAGGTGACAAGCCTGGGTTTCTCCCAGGATAGGTGAAAGGGTTAAAATGAGTAAAGCAGTTGAGCAAACACCAACC
CGAGCTTCGGGCGCAGAATTCTTCACCTTCTCTTCCCCTTTCCATCTCCTTTCCCCGCGGAAACAACGCTTCCCTTCTGGTGTGTCTGTT
GATCTGTGTTTTCATTTACATCTCTCTTAGACTCCGCTCTTGTTCTCCAGGTTTTCACCAGATAGATTTGGGGTTGGCGGGACCTGCTGG
TGACGTGCAGGTGAAGGACAGGAAGGGGCATGTGAGCGTAAATAGAGGTGACCAGAGGAGAGCATGAGGGGTGGGGCTTTGGGACCCACC
GGGGCCAGTGGCTGGAGCTTGACGTCTTTCCTCCCCATGGGGGTGGGAGGGCCCCCAGCTGGAAGAGCAGACTCCCAGCTGCTACCCCCT
CCCTTCCCATGGGAGTGGCTTTCCATTTTGGGCAGAATGCTGACTAGTAGACTAACATAAAAGATATAAAAGGCAATAACTATTGTTTGT
GAGCAACTTTTTTATAACTTCCAAAACAAAAACCTGAGCACAGTTTTGAAGTTCTAGCCACTCGAGCTCATGCATGTGAAACGTGTGCTT
TACGAAGGTGGCAGCTGACAGACGTGGGCTCTGCATGCCGCCAGCCTAGTAGAAAGTTCTCGTTCATTGGCAACAGCAGAACCTGCCTCT
CCGTGAAGTCGTCAGCCTAAAATTTGTTTCTCTCTTGAAGAGGATTCTTTGAAAAGGTCCTGCAGAGAAATCAGTACAGGTTATCCCGAA
AGGTACAAGGACGCACTTGTAAAGATGATTAAAACGTATCTTTCCTTTATGTGACGCGTCTCTAGTGCCTTACTGAAGAAGCAGTGACAC
TCCCGTCGCTCGGTGAGGACGTTCCCGGACAGTGCCTCACTCACCTGGGACTGGTATCCCCTCCCAGGGTCCACCAAGGGCTCCTGCTTT
TCAGACACCCCATCATCCTCGCGCGTCCTCACCCTGTCTCTACCAGGGAGGTGCCTAGCTTGGTGAGGTTACTCCTGCTCCTCCAACCTT
TTTTTGCCAAGGTTTGTACACGACTCCCATCTAGGCTGAAAACCTAGAAGTGGACCTTGTGTGTGTGCATGGTGTCAGCCCAAAGCCAGG
CTGAGACAGTCCTCATATCCTCTTGAGCCAAACTGTTTGGGTCTCGTTGCTTCATGGTATGGTCTGGATTTGTGGGAATGGCTTTGCGTG
AGAAAGGGGAGGAGAGTGGTTGCTGCCCTCAGCCGGCTTGAGGACAGAGCCTGTCCCTCTCATGACAACTCAGTGTTGAAGCCCAGTGTC
CTCAGCTTCATGTCCAGTGGATGGCAGAAGTTCATGGGGTAGTGGCCTCTCAAAGGCTGGGCGCATCCCAAGACAGCCAGCAGGTTGTCT
CTGGAAACGACCAGAGTTAAGCTCTCGGCTTCTCTGCTGAGGGTGCACCCTTTCCTCTAGATGGTAGTTGTCACGTTATCTTTGAAAACT
CTTGGACTGCTCCTGAGGAGGCCCTCTTTTCCAGTAGGAAGTTAGATGGGGGTTCTCAGAAGTGGCTGATTGGAAGGGGACAAGCTTCGT
TTCAGGGGTCTGCCGTTCCATCCTGGTTCAGAGAAGGCCGAGCGTGGCTTTCTCTAGCCTTGTCACTGTCTCCCTGCCTGTCAATCACCA
CCTTTCCTCCAGAGGAGGAAAATTATCTCCCCTGCAAAGCCCGGTTCTACACAGATTTCACAAATTGTGCTAAGAACCGTCCGTGTTCTC
AGAAAGCCCAGTGTTTTTGCAAAGAATGAAAAGGGACCCCATATGTAGCAAAAATCAGGGCTGGGGGAGAGCCGGGTTCATTCCCTGTCC
TCATTGGTCGTCCCTATGAATTGTACGTTTCAGAGAAATTTTTTTTCCTATGTGCAACACGAAGCTTCCAGAACCATAAAATATCCCGTC
GATAAGGAAAGAAAATGTCGTTGTTGTTGTTTTTCTGGAAACTGCTTGAAATCTTGCTGTACTATAGAGCTCAGAAGGACACAGCCCGTC
CTCCCCTGCCTGCCTGATTCCATGGCTGTTGTGCTGATTCCAATGCTTTCACGTTGGTTCCTGGCGTGGGAACTGCTCTCCTTTGCAGCC
CCATTTCCCAAGCTCTGTTCAAGTTAAACTTATGTAAGCTTTCCGTGGCATGCGGGGCGCGCACCCACGTCCCCGCTGCGTAAGACTCTG
TATTTGGATGCCAATCCACAGGCCTGAAGAAACTGCTTGTTGTGTATCAGTAATCATTAGTGGCAATGATGACATTCTGAAAAGCTGCAA

>6449_6449_1_ARID3A-PMEPA1_ARID3A_chr19_968503_ENST00000263620_PMEPA1_chr20_56234753_ENST00000341744_length(amino acids)=829AA_BP=209
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMKPKWEEEEME
EDLGEDEEEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPRKAQPPQAFRGDGVPRVLGGQERPGPGPAHPGGAAHVAPQLQPPDHGDW
TYEEQFKQLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFT
LRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGSLFAYSPGGAHGMLSSPKLPVSSLGLAASTNGSSITPAPKIKKEEDS
AIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESAEPPEKKMALVADEQQRLMQRALQQNFLAMAAQLPMSI
RINSQASESRQDSAVNLTGTNGSNSISMSVEINGIMYTAELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSS
EGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLEL
NRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAP

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Fusion Gene PPI Analysis for ARID3A-PMEPA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARID3A-PMEPA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARID3A-PMEPA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource