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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PGAP1-AOX1 (FusionGDB2 ID:64534)

Fusion Gene Summary for PGAP1-AOX1

Fusion gene summary

Fusion gene information	Fusion gene name: PGAP1-AOX1
	Fusion gene ID: 64534
		Hgene	Tgene
	Gene symbol	PGAP1	AOX1
	Gene ID	80055	316
	Gene name	post-GPI attachment to proteins inositol deacylase 1	aldehyde oxidase 1
	Synonyms	Bst1\|ISPD3024\|MRT42\|SPG67	AO\|AOH1
	Cytomap	2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	GPI inositol-deacylasepost-GPI attachment to proteins 1post-GPI attachment to proteins factor 1	aldehyde oxidaseazaheterocycle hydroxylase
	Modification date	20200313	20200313
	UniProtAcc	.	Q06278
	Ensembl transtripts involved in fusion gene	ENST00000354764, ENST00000409475, ENST00000409188, ENST00000485830,	ENST00000485106, ENST00000374700,
Fusion gene scores	* DoF score	9 X 12 X 7=756	2 X 2 X 2=8
	# samples	10	2
	** MAII score	log2(10/756*10)=-2.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: PGAP1 [Title/Abstract] AND AOX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PGAP1(197740469)-AOX1(201473706), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AOX1	GO:0017144	drug metabolic process	20444863\|22031625\|22522748\|23857892
Tgene	AOX1	GO:0055114	oxidation-reduction process	22279051\|22996261

Fusion gene breakpoints across PGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AOX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-Q9-A6FW	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+

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Fusion Gene ORF analysis for PGAP1-AOX1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000354764	ENST00000485106	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+
5CDS-intron	ENST00000409475	ENST00000485106	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+
In-frame	ENST00000354764	ENST00000374700	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+
In-frame	ENST00000409475	ENST00000374700	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+
intron-3CDS	ENST00000409188	ENST00000374700	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+
intron-3CDS	ENST00000485830	ENST00000374700	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+
intron-intron	ENST00000409188	ENST00000485106	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+
intron-intron	ENST00000485830	ENST00000485106	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000354764

PGAP1

chr2

197740469

ENST00000374700

AOX1

chr2

201473706

5463

1541

4650

1533

ENST00000409475

PGAP1

chr2

197740469

ENST00000374700

AOX1

chr2

201473706

5462

1540

4649

1533

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000354764	ENST00000374700	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+	0.000234019	0.99976593
ENST00000409475	ENST00000374700	PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+	0.000233828	0.9997662

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Fusion Genomic Features for PGAP1-AOX1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+	4.41E-06	0.9999956
PGAP1	chr2	197740469	-	AOX1	chr2	201473706	+	4.41E-06	0.9999956

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGAP1-AOX1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:197740469/chr2:201473706)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AOX1 Q06278
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. {ECO:0000269\|PubMed:20444863, ECO:0000269\|PubMed:22031625, ECO:0000269\|PubMed:22279051, ECO:0000269\|PubMed:22522748, ECO:0000269\|PubMed:22996261, ECO:0000269\|PubMed:23857892, ECO:0000269\|PubMed:26322824, ECO:0000269\|PubMed:7786031, ECO:0000269\|PubMed:9224775}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

1_11

475

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

1_11

475

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

12_32

475

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

12_32

475

593.0

Transmembrane

Helical

Tgene

AOX1

chr2:197740469

chr2:201473706

ENST00000374700

1088_1091

302

1339.0

Region

Molybdopterin binding

Tgene

AOX1

chr2:197740469

chr2:201473706

ENST00000374700

806_807

302

1339.0

Region

Molybdopterin binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

33_641

475

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

663_668

475

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

690_733

475

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

755_817

475

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

839_853

475

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

875_893

475

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

915_922

475

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

33_641

475

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

663_668

475

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

690_733

475

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

755_817

475

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

839_853

475

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

875_893

475

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

915_922

475

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

642_662

475

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

669_689

475

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

734_754

475

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

818_838

475

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

854_874

475

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000354764

894_914

475

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

642_662

475

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

669_689

475

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

734_754

475

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

818_838

475

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

854_874

475

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197740469

chr2:201473706

ENST00000409475

894_914

475

593.0

Transmembrane

Helical

Tgene

AOX1

chr2:197740469

chr2:201473706

ENST00000374700

236_421

302

1339.0

Domain

FAD-binding PCMH-type

Tgene

AOX1

chr2:197740469

chr2:201473706

ENST00000374700

5_92

302

1339.0

Domain

2Fe-2S ferredoxin-type

Tgene

AOX1

chr2:197740469

chr2:201473706

ENST00000374700

264_271

302

1339.0

Nucleotide binding

FAD

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Fusion Gene Sequence for PGAP1-AOX1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64534_64534_1_PGAP1-AOX1_PGAP1_chr2_197740469_ENST00000354764_AOX1_chr2_201473706_ENST00000374700_length(transcript)=5463nt_BP=1541nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGA
ACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCC
TTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGC
AGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAA
GCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGGTCAAGAATTTGCTCCAAAAAGTGTGGCAATAATTGG
TCATTCTATGGGTGGCCTTGTTGCAAGAGCATTGCTTACACTGAAAAATTTTAAGCATGATCTGATAAATCTTCTTATTACACAAGCCAC
ACCTCATGTTGCTCCTGTGATGCCATTAGATCGTTTCATTACAGATTTTTATACGACTGTAAACAACTATTGGATTCTAAATGCTCGACA
CATAAATTTAACCACACTTTCTGTAGCTGGAGGATTCCGGGATTACCAAGTTCGTTCAGGATTGACTTTTCTACCAAAATTAAGCCATCA
TACCAGTGCCTTATCTGTTGTGAGTTCAGCAGTGCCTAAGACCTGGGTCTCAACAGACCACCTCTCCATTGTGTGGTGTAAACAATTGCA
GTTGACTACAGTTCGAGCATTCTTTGATCTTATTGATGCTGATACTAAACAAATAACTCAAAATTCCAAGAAGAAACTGTCAGTTTTGTA
TCACCACTTTATAAGACACCCATCAAAACATTTTGAGGAAAATCCAGCTATAATTTCTGACTTAACAGGGACATCTATGTGGGTTCTAGT
AAAAGTGTCCAAATGGACCTATGTAGCTTACAACGAATCTGAGAAGATATATTTTACATTTCCTCTTGAAAATCATAGAAAAATCTACAC
TCATGTCTATTGTCAGAGCACTATGCTGGATACAAATAGTTGGATTTTTGCTTGCATAAACAGCACTTCTATGTGCCTGCAAGGGGTTGA
TTTATCATGGAAAGCTGAACTGCTGCCAACAATTAAGTATCTGACATTAAGACTTCAAGACTATCCATCTTTGTCTCATCTTGTTGTTTA
TGTACCATCTGTTCGTGGAAGTAAGTTTGTTGTAGATTGTGAATTCTTTAAAAAAGAGAAAAGATACATACAGCTTCCTGTAACTCATCT
TTTTTCCTTTGGACTCACCCTTGGTGCTGGTCTCAGCCTAGCCCAGGTGAAGGACATTTTGGCTGATGTAGTCCAGAAGCTTCCAGAGGA
GAAGACACAGATGTACCATGCTCTCCTGAAGCATTTGGGAACTCTGGCTGGGTCCCAGATCAGGAACATGGCTTCTTTAGGGGGACACAT
CATTAGCAGGCATCCAGATTCAGATCTGAATCCCATCCTGGCTGTGGGTAACTGTACCCTCAACTTGCTATCAAAAGAAGGAAAACGACA
GATTCCTTTAAATGAGCAATTCCTCAGCAAGTGCCCTAATGCAGATCTTAAGCCTCAAGAAATCTTGGTCTCAGTGAACATCCCCTACTC
AAGGAAGTGGGAATTTGTGTCAGCCTTCCGACAAGCCCAGCGACAGGAGAATGCGCTAGCGATAGTCAATTCAGGAATGAGAGTCTTTTT
TGGAGAAGGGGATGGCATTATTAGAGAGTTATGCATCTCATATGGAGGCGTTGGTCCAGCCACCATCTGTGCCAAGAATTCCTGCCAGAA
ACTCATTGGAAGGCACTGGAACGAACAGATGCTGGATATAGCCTGCAGGCTTATTCTGAATGAAGTCTCCCTTTTGGGCTCGGCGCCAGG
TGGGAAAGTGGAGTTCAAGAGGACTCTCATCATCAGCTTCCTCTTCAAGTTCTACCTGGAAGTGTCACAGATTTTGAAAAAGATGGATCC
AGTTCACTATCCTAGCCTTGCAGACAAGTATGAAAGTGCTTTAGAAGATCTTCATTCCAAACATCACTGCAGTACATTAAAGTACCAGAA
TATAGGCCCAAAGCAGCATCCTGAAGACCCAATTGGCCACCCCATCATGCATCTGTCTGGTGTGAAGCATGCCACGGGGGAGGCCATCTA
CTGTGATGACATGCCTCTGGTGGACCAGGAACTTTTCTTGACTTTTGTGACTAGTTCAAGAGCTCATGCTAAGATTGTGTCTATTGATCT
GTCAGAAGCTCTCAGCATGCCCGGTGTGGTGGACATCATGACAGCAGAACATCTTAGTGACGTCAACTCCTTCTGCTTTTTTACTGAAGC
TGAGAAATTTCTGGCGACAGATAAGGTGTTCTGTGTGGGTCAGCTTGTCTGTGCTGTGCTTGCCGATTCTGAGGTTCAGGCAAAGCGAGC
TGCTAAGCGAGTGAAGATTGTCTATCAAGACTTGGAGCCGCTGATACTAACAATTGAGGAAAGTATACAACACAACTCCTCCTTCAAGCC
AGAAAGGAAACTGGAATATGGAAATGTTGACGAAGCATTTAAAGTGGTTGATCAAATTCTTGAAGGTGAAATACATATGGGAGGTCAAGA
ACATTTTTATATGGAAACCCAAAGCATGCTTGTCGTTCCCAAGGGAGAGGATCAAGAAATGGATGTCTACGTGTCCACACAGTTTCCCAA
ATATATACAGGACATTGTTGCCTCAACCTTGAAGCTCCCAGCTAACAAGGTCATGTGCCATGTAAGGCGTGTTGGTGGAGCGTTTGGAGG
GAAGGTGTTAAAAACCGGAATCATTGCAGCCGTCACTGCATTTGCCGCAAACAAACATGGCCGTGCAGTTCGCTGTGTTCTGGAACGAGG
AGAAGACATGTTAATAACTGGAGGCCGCCATCCTTACCTTGGAAAGTACAAAGCTGGATTCATGAACGATGGCAGAATCTTGGCCCTGGA
CATGGAGCATTACAGCAATGCAGGCGCCTCCTTGGATGAATCATTATTCGTGATAGAAATGGGACTTCTGAAAATGGACAATGCTTACAA
GTTTCCCAATCTCCGCTGCCGGGGTTGGGCATGCAGAACCAACCTTCCATCCAACACAGCTTTTCGTGGGTTTGGCTTTCCTCAGGCAGC
GCTGATCACCGAATCTTGTATCACGGAAGTTGCAGCCAAATGTGGACTATCCCCTGAGAAGGTGCGAATCATAAACATGTACAAGGAAAT
TGATCAAACACCCTACAAACAAGAGATCAATGCCAAGAACCTAATCCAGTGTTGGAGAGAATGTATGGCCATGTCTTCCTACTCCTTGAG
GAAAGTTGCTGTGGAAAAGTTCAATGCAGAGAATTATTGGAAGAAGAAAGGACTGGCCATGGTCCCCCTGAAGTTTCCTGTTGGCCTTGG
CTCACGTGCTGCTGGTCAGGCTGCTGCCTTGGTTCACATTTATCTTGATGGCTCTGTGCTGGTCACTCACGGTGGAATTGAAATGGGGCA
GGGGGTCCACACTAAAATGATTCAGGTGGTCAGCCGTGAATTAAGAATGCCAATGTCGAATGTCCACCTGCGTGGAACAAGCACAGAAAC
TGTCCCTAATGCAAATATCTCTGGAGGTTCTGTGGTGGCAGATCTCAACGGTTTGGCAGTAAAGGATGCCTGTCAAACTCTTCTAAAACG
CCTCGAACCCATCATCAGCAAGAATCCTAAAGGAACTTGGAAAGACTGGGCACAGACTGCTTTTGATGAAAGCATTAACCTTTCAGCTGT
TGGATACTTCAGAGGTTATGAGTCAGACATGAACTGGGAGAAAGGCGAAGGCCAGCCCTTCGAATACTTTGTTTATGGAGCTGCCTGTTC
CGAGGTTGAAATAGACTGCCTGACGGGGGATCATAAGAACATCAGAACAGACATTGTCATGGATGTTGGCTGCAGTATAAATCCAGCCAT
TGACATAGGCCAGATTGAAGGTGCATTTATTCAAGGCATGGGACTTTATACAATAGAGGAACTGAATTATTCTCCCCAGGGCATTCTGCA
CACTCGTGGTCCAGACCAATATAAAATCCCTGCCATCTGTGACATGCCCACGGAGTTGCACATTGCTTTGTTGCCTCCTTCTCAAAACTC
AAATACTCTTTATTCATCTAAGGGTCTGGGAGAGTCGGGGGTGTTCCTGGGGTGTTCCGTGTTTTTCGCTATCCATGACGCAGTGAGTGC
AGCACGACAGGAGAGAGGCCTGCATGGACCCTTGACCCTTAATAGTCCACTGACCCCGGAGAAGATTAGGATGGCCTGTGAAGACAAGTT
CACAAAAATGATTCCGAGAGATGAACCTGGATCCTACGTTCCTTGGAATGTACCCATCTGAATCAAATGCAAACTTCTGGAGAAAACAGA
GTGCCTCTTCCCAGATGGCAATCTGTCCTATCTCTGTGCTGGAAGATGCTAGATCTGAAAGACAGAGTTTCCACAGTTCAGAAATCATCC
CACAGTGTTGCTTTTCTATGGAGCTGATTTAAAGTATTCCATTTAGATTTGATAGATATGCTTAAGCAATCTATAAATCATTTTCAATGT
TATAAACACTAATTGGTTTCCTCTAGGGTGATATCCGTCATTACTCTGTCTCTTCAATCCATCCAGCTAAATGGAATAGGTGATGACTTG
CATGTGACTCCTACTTGGCTTCTATCCACCAACAGAAATTATACCATATAGTGAAAGGCAATTTTCTAAATAATTTCATTACTAATATGA
ACTGTGAAGTTGTCATTTTTTCATTTGTCCTTTTCTGCTATCACCTTCCTCTTGTCAGAATGAATATAGACACTGTATCTAAGTGGGACC
AAAGAAAAAATAGCGAACTTTCACCAAAGTTTTCATGAAAACCCAAAAGCTTTAAAAGTTACTATCAAGAAATTGAAAGGAAACCCACAG
AATAGGATAAAATATTTGTAAATCATATATTTGATAAAAGTCTTGTAACCAGATACATAAAGAGCTCTTACAACTCAATAAAAGGCAAGT
AATTTAAAAATAGGCAAAAGAATTGCTGGATGGTATGGTAGTTCTATTTTTAGTTTTTACCCTAACTACTCTGACTTGATCATTTAACAT

>64534_64534_1_PGAP1-AOX1_PGAP1_chr2_197740469_ENST00000354764_AOX1_chr2_201473706_ENST00000374700_length(amino acids)=1533AA_BP=497
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKYLTL
RLQDYPSLSHLVVYVPSVRGSKFVVDCEFFKKEKRYIQLPVTHLFSFGLTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLA
GSQIRNMASLGGHIISRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSRKWEFVSAFRQAQRQE
NALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFK
FYLEVSQILKKMDPVHYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFLTFV
TSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAEKFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLIL
TIEESIQHNSSFKPERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVASTLKLPANK
VMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGEDMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLF
VIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYKQEINAKNLIQ
CWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRM
PMSNVHLRGTSTETVPNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVGYFRGYESDMNWEKGE
GQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMP
TELHIALLPPSQNSNTLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFTKMIPRDEPGSYVPWN

--------------------------------------------------------------
>64534_64534_2_PGAP1-AOX1_PGAP1_chr2_197740469_ENST00000409475_AOX1_chr2_201473706_ENST00000374700_length(transcript)=5462nt_BP=1540nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGAA
CTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCCT
TTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCA
GAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAG
CAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGGTCAAGAATTTGCTCCAAAAAGTGTGGCAATAATTGGT
CATTCTATGGGTGGCCTTGTTGCAAGAGCATTGCTTACACTGAAAAATTTTAAGCATGATCTGATAAATCTTCTTATTACACAAGCCACA
CCTCATGTTGCTCCTGTGATGCCATTAGATCGTTTCATTACAGATTTTTATACGACTGTAAACAACTATTGGATTCTAAATGCTCGACAC
ATAAATTTAACCACACTTTCTGTAGCTGGAGGATTCCGGGATTACCAAGTTCGTTCAGGATTGACTTTTCTACCAAAATTAAGCCATCAT
ACCAGTGCCTTATCTGTTGTGAGTTCAGCAGTGCCTAAGACCTGGGTCTCAACAGACCACCTCTCCATTGTGTGGTGTAAACAATTGCAG
TTGACTACAGTTCGAGCATTCTTTGATCTTATTGATGCTGATACTAAACAAATAACTCAAAATTCCAAGAAGAAACTGTCAGTTTTGTAT
CACCACTTTATAAGACACCCATCAAAACATTTTGAGGAAAATCCAGCTATAATTTCTGACTTAACAGGGACATCTATGTGGGTTCTAGTA
AAAGTGTCCAAATGGACCTATGTAGCTTACAACGAATCTGAGAAGATATATTTTACATTTCCTCTTGAAAATCATAGAAAAATCTACACT
CATGTCTATTGTCAGAGCACTATGCTGGATACAAATAGTTGGATTTTTGCTTGCATAAACAGCACTTCTATGTGCCTGCAAGGGGTTGAT
TTATCATGGAAAGCTGAACTGCTGCCAACAATTAAGTATCTGACATTAAGACTTCAAGACTATCCATCTTTGTCTCATCTTGTTGTTTAT
GTACCATCTGTTCGTGGAAGTAAGTTTGTTGTAGATTGTGAATTCTTTAAAAAAGAGAAAAGATACATACAGCTTCCTGTAACTCATCTT
TTTTCCTTTGGACTCACCCTTGGTGCTGGTCTCAGCCTAGCCCAGGTGAAGGACATTTTGGCTGATGTAGTCCAGAAGCTTCCAGAGGAG
AAGACACAGATGTACCATGCTCTCCTGAAGCATTTGGGAACTCTGGCTGGGTCCCAGATCAGGAACATGGCTTCTTTAGGGGGACACATC
ATTAGCAGGCATCCAGATTCAGATCTGAATCCCATCCTGGCTGTGGGTAACTGTACCCTCAACTTGCTATCAAAAGAAGGAAAACGACAG
ATTCCTTTAAATGAGCAATTCCTCAGCAAGTGCCCTAATGCAGATCTTAAGCCTCAAGAAATCTTGGTCTCAGTGAACATCCCCTACTCA
AGGAAGTGGGAATTTGTGTCAGCCTTCCGACAAGCCCAGCGACAGGAGAATGCGCTAGCGATAGTCAATTCAGGAATGAGAGTCTTTTTT
GGAGAAGGGGATGGCATTATTAGAGAGTTATGCATCTCATATGGAGGCGTTGGTCCAGCCACCATCTGTGCCAAGAATTCCTGCCAGAAA
CTCATTGGAAGGCACTGGAACGAACAGATGCTGGATATAGCCTGCAGGCTTATTCTGAATGAAGTCTCCCTTTTGGGCTCGGCGCCAGGT
GGGAAAGTGGAGTTCAAGAGGACTCTCATCATCAGCTTCCTCTTCAAGTTCTACCTGGAAGTGTCACAGATTTTGAAAAAGATGGATCCA
GTTCACTATCCTAGCCTTGCAGACAAGTATGAAAGTGCTTTAGAAGATCTTCATTCCAAACATCACTGCAGTACATTAAAGTACCAGAAT
ATAGGCCCAAAGCAGCATCCTGAAGACCCAATTGGCCACCCCATCATGCATCTGTCTGGTGTGAAGCATGCCACGGGGGAGGCCATCTAC
TGTGATGACATGCCTCTGGTGGACCAGGAACTTTTCTTGACTTTTGTGACTAGTTCAAGAGCTCATGCTAAGATTGTGTCTATTGATCTG
TCAGAAGCTCTCAGCATGCCCGGTGTGGTGGACATCATGACAGCAGAACATCTTAGTGACGTCAACTCCTTCTGCTTTTTTACTGAAGCT
GAGAAATTTCTGGCGACAGATAAGGTGTTCTGTGTGGGTCAGCTTGTCTGTGCTGTGCTTGCCGATTCTGAGGTTCAGGCAAAGCGAGCT
GCTAAGCGAGTGAAGATTGTCTATCAAGACTTGGAGCCGCTGATACTAACAATTGAGGAAAGTATACAACACAACTCCTCCTTCAAGCCA
GAAAGGAAACTGGAATATGGAAATGTTGACGAAGCATTTAAAGTGGTTGATCAAATTCTTGAAGGTGAAATACATATGGGAGGTCAAGAA
CATTTTTATATGGAAACCCAAAGCATGCTTGTCGTTCCCAAGGGAGAGGATCAAGAAATGGATGTCTACGTGTCCACACAGTTTCCCAAA
TATATACAGGACATTGTTGCCTCAACCTTGAAGCTCCCAGCTAACAAGGTCATGTGCCATGTAAGGCGTGTTGGTGGAGCGTTTGGAGGG
AAGGTGTTAAAAACCGGAATCATTGCAGCCGTCACTGCATTTGCCGCAAACAAACATGGCCGTGCAGTTCGCTGTGTTCTGGAACGAGGA
GAAGACATGTTAATAACTGGAGGCCGCCATCCTTACCTTGGAAAGTACAAAGCTGGATTCATGAACGATGGCAGAATCTTGGCCCTGGAC
ATGGAGCATTACAGCAATGCAGGCGCCTCCTTGGATGAATCATTATTCGTGATAGAAATGGGACTTCTGAAAATGGACAATGCTTACAAG
TTTCCCAATCTCCGCTGCCGGGGTTGGGCATGCAGAACCAACCTTCCATCCAACACAGCTTTTCGTGGGTTTGGCTTTCCTCAGGCAGCG
CTGATCACCGAATCTTGTATCACGGAAGTTGCAGCCAAATGTGGACTATCCCCTGAGAAGGTGCGAATCATAAACATGTACAAGGAAATT
GATCAAACACCCTACAAACAAGAGATCAATGCCAAGAACCTAATCCAGTGTTGGAGAGAATGTATGGCCATGTCTTCCTACTCCTTGAGG
AAAGTTGCTGTGGAAAAGTTCAATGCAGAGAATTATTGGAAGAAGAAAGGACTGGCCATGGTCCCCCTGAAGTTTCCTGTTGGCCTTGGC
TCACGTGCTGCTGGTCAGGCTGCTGCCTTGGTTCACATTTATCTTGATGGCTCTGTGCTGGTCACTCACGGTGGAATTGAAATGGGGCAG
GGGGTCCACACTAAAATGATTCAGGTGGTCAGCCGTGAATTAAGAATGCCAATGTCGAATGTCCACCTGCGTGGAACAAGCACAGAAACT
GTCCCTAATGCAAATATCTCTGGAGGTTCTGTGGTGGCAGATCTCAACGGTTTGGCAGTAAAGGATGCCTGTCAAACTCTTCTAAAACGC
CTCGAACCCATCATCAGCAAGAATCCTAAAGGAACTTGGAAAGACTGGGCACAGACTGCTTTTGATGAAAGCATTAACCTTTCAGCTGTT
GGATACTTCAGAGGTTATGAGTCAGACATGAACTGGGAGAAAGGCGAAGGCCAGCCCTTCGAATACTTTGTTTATGGAGCTGCCTGTTCC
GAGGTTGAAATAGACTGCCTGACGGGGGATCATAAGAACATCAGAACAGACATTGTCATGGATGTTGGCTGCAGTATAAATCCAGCCATT
GACATAGGCCAGATTGAAGGTGCATTTATTCAAGGCATGGGACTTTATACAATAGAGGAACTGAATTATTCTCCCCAGGGCATTCTGCAC
ACTCGTGGTCCAGACCAATATAAAATCCCTGCCATCTGTGACATGCCCACGGAGTTGCACATTGCTTTGTTGCCTCCTTCTCAAAACTCA
AATACTCTTTATTCATCTAAGGGTCTGGGAGAGTCGGGGGTGTTCCTGGGGTGTTCCGTGTTTTTCGCTATCCATGACGCAGTGAGTGCA
GCACGACAGGAGAGAGGCCTGCATGGACCCTTGACCCTTAATAGTCCACTGACCCCGGAGAAGATTAGGATGGCCTGTGAAGACAAGTTC
ACAAAAATGATTCCGAGAGATGAACCTGGATCCTACGTTCCTTGGAATGTACCCATCTGAATCAAATGCAAACTTCTGGAGAAAACAGAG
TGCCTCTTCCCAGATGGCAATCTGTCCTATCTCTGTGCTGGAAGATGCTAGATCTGAAAGACAGAGTTTCCACAGTTCAGAAATCATCCC
ACAGTGTTGCTTTTCTATGGAGCTGATTTAAAGTATTCCATTTAGATTTGATAGATATGCTTAAGCAATCTATAAATCATTTTCAATGTT
ATAAACACTAATTGGTTTCCTCTAGGGTGATATCCGTCATTACTCTGTCTCTTCAATCCATCCAGCTAAATGGAATAGGTGATGACTTGC
ATGTGACTCCTACTTGGCTTCTATCCACCAACAGAAATTATACCATATAGTGAAAGGCAATTTTCTAAATAATTTCATTACTAATATGAA
CTGTGAAGTTGTCATTTTTTCATTTGTCCTTTTCTGCTATCACCTTCCTCTTGTCAGAATGAATATAGACACTGTATCTAAGTGGGACCA
AAGAAAAAATAGCGAACTTTCACCAAAGTTTTCATGAAAACCCAAAAGCTTTAAAAGTTACTATCAAGAAATTGAAAGGAAACCCACAGA
ATAGGATAAAATATTTGTAAATCATATATTTGATAAAAGTCTTGTAACCAGATACATAAAGAGCTCTTACAACTCAATAAAAGGCAAGTA
ATTTAAAAATAGGCAAAAGAATTGCTGGATGGTATGGTAGTTCTATTTTTAGTTTTTACCCTAACTACTCTGACTTGATCATTTAACATT

>64534_64534_2_PGAP1-AOX1_PGAP1_chr2_197740469_ENST00000409475_AOX1_chr2_201473706_ENST00000374700_length(amino acids)=1533AA_BP=497
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKYLTL
RLQDYPSLSHLVVYVPSVRGSKFVVDCEFFKKEKRYIQLPVTHLFSFGLTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLA
GSQIRNMASLGGHIISRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSRKWEFVSAFRQAQRQE
NALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFK
FYLEVSQILKKMDPVHYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFLTFV
TSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAEKFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLIL
TIEESIQHNSSFKPERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVASTLKLPANK
VMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGEDMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLF
VIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYKQEINAKNLIQ
CWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRM
PMSNVHLRGTSTETVPNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVGYFRGYESDMNWEKGE
GQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMP
TELHIALLPPSQNSNTLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFTKMIPRDEPGSYVPWN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PGAP1-AOX1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PGAP1-AOX1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PGAP1-AOX1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source