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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PGAP1-HSPD1 (FusionGDB2 ID:64537)

Fusion Gene Summary for PGAP1-HSPD1

Fusion gene summary

Fusion gene information	Fusion gene name: PGAP1-HSPD1
	Fusion gene ID: 64537
		Hgene	Tgene
	Gene symbol	PGAP1	HSPD1
	Gene ID	80055	3329
	Gene name	post-GPI attachment to proteins inositol deacylase 1	heat shock protein family D (Hsp60) member 1
	Synonyms	Bst1\|ISPD3024\|MRT42\|SPG67	CPN60\|GROEL\|HLD4\|HSP-60\|HSP60\|HSP65\|HuCHA60\|SPG13
	Cytomap	2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	GPI inositol-deacylasepost-GPI attachment to proteins 1post-GPI attachment to proteins factor 1	60 kDa heat shock protein, mitochondrial60 kDa chaperoninP60 lymphocyte proteinchaperonin 60epididymis secretory sperm binding proteinheat shock 60kDa protein 1 (chaperonin)heat shock protein 65mitochondrial matrix protein P1short heat shock prote
	Modification date	20200313	20200315
	UniProtAcc	.	P10809
	Ensembl transtripts involved in fusion gene	ENST00000354764, ENST00000409475, ENST00000409188, ENST00000485830,	ENST00000544407, ENST00000345042, ENST00000388968,
Fusion gene scores	* DoF score	9 X 12 X 7=756	14 X 10 X 6=840
	# samples	10	16
	** MAII score	log2(10/756*10)=-2.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/840*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PGAP1 [Title/Abstract] AND HSPD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PGAP1(197750148)-HSPD1(198362116), # samples:2
Anticipated loss of major functional domain due to fusion event.	PGAP1-HSPD1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PGAP1-HSPD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PGAP1-HSPD1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PGAP1-HSPD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PGAP1-HSPD1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HSPD1	GO:0002368	B cell cytokine production	16148103
Tgene	HSPD1	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	16148103
Tgene	HSPD1	GO:0002842	positive regulation of T cell mediated immune response to tumor cell	10663613
Tgene	HSPD1	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	17823127
Tgene	HSPD1	GO:0006986	response to unfolded protein	11050098
Tgene	HSPD1	GO:0032727	positive regulation of interferon-alpha production	17164250
Tgene	HSPD1	GO:0032729	positive regulation of interferon-gamma production	17164250
Tgene	HSPD1	GO:0032733	positive regulation of interleukin-10 production	16148103
Tgene	HSPD1	GO:0032735	positive regulation of interleukin-12 production	17164250
Tgene	HSPD1	GO:0032755	positive regulation of interleukin-6 production	16148103
Tgene	HSPD1	GO:0042026	protein refolding	11050098
Tgene	HSPD1	GO:0042100	B cell proliferation	16148103
Tgene	HSPD1	GO:0042110	T cell activation	15371451\|17164250\|18256040
Tgene	HSPD1	GO:0042113	B cell activation	16148103
Tgene	HSPD1	GO:0043032	positive regulation of macrophage activation	17164250
Tgene	HSPD1	GO:0044406	adhesion of symbiont to host	20633027
Tgene	HSPD1	GO:0048291	isotype switching to IgG isotypes	16148103
Tgene	HSPD1	GO:0050870	positive regulation of T cell activation	16148103\|17164250

Fusion gene breakpoints across PGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HSPD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5J7-01A	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-

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Fusion Gene ORF analysis for PGAP1-HSPD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000354764	ENST00000544407	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
Frame-shift	ENST00000409475	ENST00000544407	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
In-frame	ENST00000354764	ENST00000345042	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
In-frame	ENST00000354764	ENST00000388968	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
In-frame	ENST00000409475	ENST00000345042	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
In-frame	ENST00000409475	ENST00000388968	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
intron-3CDS	ENST00000409188	ENST00000345042	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
intron-3CDS	ENST00000409188	ENST00000388968	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
intron-3CDS	ENST00000409188	ENST00000544407	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
intron-3CDS	ENST00000485830	ENST00000345042	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
intron-3CDS	ENST00000485830	ENST00000388968	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-
intron-3CDS	ENST00000485830	ENST00000544407	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000354764	PGAP1	chr2	197750148	-	ENST00000388968	HSPD1	chr2	198362116	-	3400	1387	49	2934	961
ENST00000354764	PGAP1	chr2	197750148	-	ENST00000345042	HSPD1	chr2	198362116	-	3395	1387	49	2934	961
ENST00000409475	PGAP1	chr2	197750148	-	ENST00000388968	HSPD1	chr2	198362116	-	3399	1386	48	2933	961
ENST00000409475	PGAP1	chr2	197750148	-	ENST00000345042	HSPD1	chr2	198362116	-	3394	1386	48	2933	961

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000354764	ENST00000388968	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-	0.000263253	0.9997367
ENST00000354764	ENST00000345042	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-	0.00027177	0.99972826
ENST00000409475	ENST00000388968	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-	0.000263254	0.9997367
ENST00000409475	ENST00000345042	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-	0.000271356	0.9997286

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Fusion Genomic Features for PGAP1-HSPD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGAP1-HSPD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:197750148/chr2:198362116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HSPD1 P10809
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269\|PubMed:11422376, ECO:0000269\|PubMed:1346131, ECO:0000305\|PubMed:25918392}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

1_11

424

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

1_11

424

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

12_32

424

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

12_32

424

593.0

Transmembrane

Helical

Tgene

HSPD1

chr2:197750148

chr2:198362116

ENST00000345042

111_115

574.0

Nucleotide binding

ATP

Tgene

HSPD1

chr2:197750148

chr2:198362116

ENST00000388968

111_115

574.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

33_641

424

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

663_668

424

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

690_733

424

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

755_817

424

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

839_853

424

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

875_893

424

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

915_922

424

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

33_641

424

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

663_668

424

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

690_733

424

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

755_817

424

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

839_853

424

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

875_893

424

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

915_922

424

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

642_662

424

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

669_689

424

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

734_754

424

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

818_838

424

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

854_874

424

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

894_914

424

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

642_662

424

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

669_689

424

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

734_754

424

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

818_838

424

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

854_874

424

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

894_914

424

593.0

Transmembrane

Helical

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Fusion Gene Sequence for PGAP1-HSPD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64537_64537_1_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000354764_HSPD1_chr2_198362116_ENST00000345042_length(transcript)=3395nt_BP=1387nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGA
ACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCC
TTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGC
AGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAA
GCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGGTCAAGAATTTGCTCCAAAAAGTGTGGCAATAATTGG
TCATTCTATGGGTGGCCTTGTTGCAAGAGCATTGCTTACACTGAAAAATTTTAAGCATGATCTGATAAATCTTCTTATTACACAAGCCAC
ACCTCATGTTGCTCCTGTGATGCCATTAGATCGTTTCATTACAGATTTTTATACGACTGTAAACAACTATTGGATTCTAAATGCTCGACA
CATAAATTTAACCACACTTTCTGTAGCTGGAGGATTCCGGGATTACCAAGTTCGTTCAGGATTGACTTTTCTACCAAAATTAAGCCATCA
TACCAGTGCCTTATCTGTTGTGAGTTCAGCAGTGCCTAAGACCTGGGTCTCAACAGACCACCTCTCCATTGTGTGGTGTAAACAATTGCA
GTTGACTACAGTTCGAGCATTCTTTGATCTTATTGATGCTGATACTAAACAAATAACTCAAAATTCCAAGAAGAAACTGTCAGTTTTGTA
TCACCACTTTATAAGACACCCATCAAAACATTTTGAGGAAAATCCAGCTATAATTTCTGACTTAACAGGGACATCTATGTGGGTTCTAGT
AAAAGTGTCCAAATGGACCTATGTAGCTTACAACGAATCTGAGAAGATATATTTTACATTTCCTCTTGAAAATCATAGAAAAATCTACAC
TCATGTCTATTGTCAGAGCACTATGCTGGATACAAATAGTTGGATTTTTGCTTGCATAAACAGCACTTCTATGTGCCTGCAAGGGGTTGA
TTTATCATGGAAAGCTGAACTGCTGCCAACAATTAAGGGAAGAACAGTGATTATTGAGCAGAGTTGGGGAAGTCCCAAAGTAACAAAAGA
TGGTGTGACTGTTGCAAAGTCAATTGACTTAAAAGATAAATACAAAAACATTGGAGCTAAACTTGTTCAAGATGTTGCCAATAACACAAA
TGAAGAAGCTGGGGATGGCACTACCACTGCTACTGTACTGGCACGCTCTATAGCCAAGGAAGGCTTCGAGAAGATTAGCAAAGGTGCTAA
TCCAGTGGAAATCAGGAGAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAACCTGTGACCACCCCTGA
AGAAATTGCACAGGTTGCTACGATTTCTGCAAACGGAGACAAAGAAATTGGCAATATCATCTCTGATGCAATGAAAAAAGTTGGAAGAAA
GGGTGTCATCACAGTAAAGGATGGAAAAACACTGAATGATGAATTAGAAATTATTGAAGGCATGAAGTTTGATCGAGGCTATATTTCTCC
ATACTTTATTAATACATCAAAAGGTCAGAAATGTGAATTCCAGGATGCCTATGTTCTGTTGAGTGAAAAGAAAATTTCTAGTATCCAGTC
CATTGTACCTGCTCTTGAAATTGCCAATGCTCACCGTAAGCCTTTGGTCATAATCGCTGAAGATGTTGATGGAGAAGCTCTAAGTACACT
CGTCTTGAATAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCAAGGCTCCAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATAT
GGCTATTGCTACTGGTGGTGCAGTGTTTGGAGAAGAGGGATTGACCCTGAATCTTGAAGACGTTCAGCCTCATGACTTAGGAAAAGTTGG
AGAGGTCATTGTGACCAAAGACGATGCCATGCTCTTAAAAGGAAAAGGTGACAAGGCTCAAATTGAAAAACGTATTCAAGAAATCATTGA
GCAGTTAGATGTCACAACTAGTGAATATGAAAAGGAAAAACTGAATGAACGGCTTGCAAAACTTTCAGATGGAGTGGCTGTGCTGAAGGT
TGGTGGGACAAGTGATGTTGAAGTGAATGAAAAGAAAGACAGAGTTACAGATGCCCTTAATGCTACAAGAGCTGCTGTTGAAGAAGGCAT
TGTTTTGGGAGGGGGTTGTGCCCTCCTTCGATGCATTCCAGCCTTGGACTCATTGACTCCAGCTAATGAAGATCAAAAAATTGGTATAGA
AATTATTAAAAGAACACTCAAAATTCCAGCAATGACCATTGCTAAGAATGCAGGTGTTGAAGGATCTTTGATAGTTGAGAAAATTATGCA
AAGTTCCTCAGAAGTTGGTTATGATGCTATGGCTGGAGATTTTGTGAATATGGTGGAAAAAGGAATCATTGACCCAACAAAGGTTGTGAG
AACTGCTTTATTGGATGCTGCTGGTGTGGCCTCTCTGTTAACTACAGCAGAAGTTGTAGTCACAGAAATTCCTAAAGAAGAGAAGGACCC
TGGAATGGGTGCAATGGGTGGAATGGGAGGTGGTATGGGAGGTGGCATGTTCTAACTCCTAGACTAGTGCTTTACCTTTATTAATGAACT
GTGACAGGAAGCCCAAGGCAGTGTTCCTCACCAATAACTTCAGAGAAGTCAGTTGGAGAAAATGAAGAAAAAGGCTGGCTGAAAATCACT
ATAACCATCAGTTACTGGTTTCAGTTGACAAAATATATAATGGTTTACTGCTGTCATTGTCCATGCCTACAGATAATTTATTTTGTATTT
TTGAATAAAAAACATTTGTACATTCCTGATACTGGGTACAAGAGCCATGTACCAGTGTACTGCTTTCAACTTAAATCACTGAGGCATTTT
TACTACTATTCTGTTAAAATCAGGATTTTAGTGCTTGCCACCACCAGATGAGAAGTTAAGCAGCCTTTCTGTGGAGAGTGAGAATAATTG

>64537_64537_1_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000354764_HSPD1_chr2_198362116_ENST00000345042_length(amino acids)=961AA_BP=446
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKGRTV
IIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI
AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDA
YVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTL
NLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVT
DALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN

--------------------------------------------------------------
>64537_64537_2_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000354764_HSPD1_chr2_198362116_ENST00000388968_length(transcript)=3400nt_BP=1387nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGA
ACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCC
TTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGC
AGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAA
GCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGGTCAAGAATTTGCTCCAAAAAGTGTGGCAATAATTGG
TCATTCTATGGGTGGCCTTGTTGCAAGAGCATTGCTTACACTGAAAAATTTTAAGCATGATCTGATAAATCTTCTTATTACACAAGCCAC
ACCTCATGTTGCTCCTGTGATGCCATTAGATCGTTTCATTACAGATTTTTATACGACTGTAAACAACTATTGGATTCTAAATGCTCGACA
CATAAATTTAACCACACTTTCTGTAGCTGGAGGATTCCGGGATTACCAAGTTCGTTCAGGATTGACTTTTCTACCAAAATTAAGCCATCA
TACCAGTGCCTTATCTGTTGTGAGTTCAGCAGTGCCTAAGACCTGGGTCTCAACAGACCACCTCTCCATTGTGTGGTGTAAACAATTGCA
GTTGACTACAGTTCGAGCATTCTTTGATCTTATTGATGCTGATACTAAACAAATAACTCAAAATTCCAAGAAGAAACTGTCAGTTTTGTA
TCACCACTTTATAAGACACCCATCAAAACATTTTGAGGAAAATCCAGCTATAATTTCTGACTTAACAGGGACATCTATGTGGGTTCTAGT
AAAAGTGTCCAAATGGACCTATGTAGCTTACAACGAATCTGAGAAGATATATTTTACATTTCCTCTTGAAAATCATAGAAAAATCTACAC
TCATGTCTATTGTCAGAGCACTATGCTGGATACAAATAGTTGGATTTTTGCTTGCATAAACAGCACTTCTATGTGCCTGCAAGGGGTTGA
TTTATCATGGAAAGCTGAACTGCTGCCAACAATTAAGGGAAGAACAGTGATTATTGAGCAGAGTTGGGGAAGTCCCAAAGTAACAAAAGA
TGGTGTGACTGTTGCAAAGTCAATTGACTTAAAAGATAAATACAAAAACATTGGAGCTAAACTTGTTCAAGATGTTGCCAATAACACAAA
TGAAGAAGCTGGGGATGGCACTACCACTGCTACTGTACTGGCACGCTCTATAGCCAAGGAAGGCTTCGAGAAGATTAGCAAAGGTGCTAA
TCCAGTGGAAATCAGGAGAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAACCTGTGACCACCCCTGA
AGAAATTGCACAGGTTGCTACGATTTCTGCAAACGGAGACAAAGAAATTGGCAATATCATCTCTGATGCAATGAAAAAAGTTGGAAGAAA
GGGTGTCATCACAGTAAAGGATGGAAAAACACTGAATGATGAATTAGAAATTATTGAAGGCATGAAGTTTGATCGAGGCTATATTTCTCC
ATACTTTATTAATACATCAAAAGGTCAGAAATGTGAATTCCAGGATGCCTATGTTCTGTTGAGTGAAAAGAAAATTTCTAGTATCCAGTC
CATTGTACCTGCTCTTGAAATTGCCAATGCTCACCGTAAGCCTTTGGTCATAATCGCTGAAGATGTTGATGGAGAAGCTCTAAGTACACT
CGTCTTGAATAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCAAGGCTCCAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATAT
GGCTATTGCTACTGGTGGTGCAGTGTTTGGAGAAGAGGGATTGACCCTGAATCTTGAAGACGTTCAGCCTCATGACTTAGGAAAAGTTGG
AGAGGTCATTGTGACCAAAGACGATGCCATGCTCTTAAAAGGAAAAGGTGACAAGGCTCAAATTGAAAAACGTATTCAAGAAATCATTGA
GCAGTTAGATGTCACAACTAGTGAATATGAAAAGGAAAAACTGAATGAACGGCTTGCAAAACTTTCAGATGGAGTGGCTGTGCTGAAGGT
TGGTGGGACAAGTGATGTTGAAGTGAATGAAAAGAAAGACAGAGTTACAGATGCCCTTAATGCTACAAGAGCTGCTGTTGAAGAAGGCAT
TGTTTTGGGAGGGGGTTGTGCCCTCCTTCGATGCATTCCAGCCTTGGACTCATTGACTCCAGCTAATGAAGATCAAAAAATTGGTATAGA
AATTATTAAAAGAACACTCAAAATTCCAGCAATGACCATTGCTAAGAATGCAGGTGTTGAAGGATCTTTGATAGTTGAGAAAATTATGCA
AAGTTCCTCAGAAGTTGGTTATGATGCTATGGCTGGAGATTTTGTGAATATGGTGGAAAAAGGAATCATTGACCCAACAAAGGTTGTGAG
AACTGCTTTATTGGATGCTGCTGGTGTGGCCTCTCTGTTAACTACAGCAGAAGTTGTAGTCACAGAAATTCCTAAAGAAGAGAAGGACCC
TGGAATGGGTGCAATGGGTGGAATGGGAGGTGGTATGGGAGGTGGCATGTTCTAACTCCTAGACTAGTGCTTTACCTTTATTAATGAACT
GTGACAGGAAGCCCAAGGCAGTGTTCCTCACCAATAACTTCAGAGAAGTCAGTTGGAGAAAATGAAGAAAAAGGCTGGCTGAAAATCACT
ATAACCATCAGTTACTGGTTTCAGTTGACAAAATATATAATGGTTTACTGCTGTCATTGTCCATGCCTACAGATAATTTATTTTGTATTT
TTGAATAAAAAACATTTGTACATTCCTGATACTGGGTACAAGAGCCATGTACCAGTGTACTGCTTTCAACTTAAATCACTGAGGCATTTT
TACTACTATTCTGTTAAAATCAGGATTTTAGTGCTTGCCACCACCAGATGAGAAGTTAAGCAGCCTTTCTGTGGAGAGTGAGAATAATTG

>64537_64537_2_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000354764_HSPD1_chr2_198362116_ENST00000388968_length(amino acids)=961AA_BP=446
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKGRTV
IIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI
AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDA
YVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTL
NLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVT
DALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN

--------------------------------------------------------------
>64537_64537_3_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000409475_HSPD1_chr2_198362116_ENST00000345042_length(transcript)=3394nt_BP=1386nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGAA
CTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCCT
TTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCA
GAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAG
CAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGGTCAAGAATTTGCTCCAAAAAGTGTGGCAATAATTGGT
CATTCTATGGGTGGCCTTGTTGCAAGAGCATTGCTTACACTGAAAAATTTTAAGCATGATCTGATAAATCTTCTTATTACACAAGCCACA
CCTCATGTTGCTCCTGTGATGCCATTAGATCGTTTCATTACAGATTTTTATACGACTGTAAACAACTATTGGATTCTAAATGCTCGACAC
ATAAATTTAACCACACTTTCTGTAGCTGGAGGATTCCGGGATTACCAAGTTCGTTCAGGATTGACTTTTCTACCAAAATTAAGCCATCAT
ACCAGTGCCTTATCTGTTGTGAGTTCAGCAGTGCCTAAGACCTGGGTCTCAACAGACCACCTCTCCATTGTGTGGTGTAAACAATTGCAG
TTGACTACAGTTCGAGCATTCTTTGATCTTATTGATGCTGATACTAAACAAATAACTCAAAATTCCAAGAAGAAACTGTCAGTTTTGTAT
CACCACTTTATAAGACACCCATCAAAACATTTTGAGGAAAATCCAGCTATAATTTCTGACTTAACAGGGACATCTATGTGGGTTCTAGTA
AAAGTGTCCAAATGGACCTATGTAGCTTACAACGAATCTGAGAAGATATATTTTACATTTCCTCTTGAAAATCATAGAAAAATCTACACT
CATGTCTATTGTCAGAGCACTATGCTGGATACAAATAGTTGGATTTTTGCTTGCATAAACAGCACTTCTATGTGCCTGCAAGGGGTTGAT
TTATCATGGAAAGCTGAACTGCTGCCAACAATTAAGGGAAGAACAGTGATTATTGAGCAGAGTTGGGGAAGTCCCAAAGTAACAAAAGAT
GGTGTGACTGTTGCAAAGTCAATTGACTTAAAAGATAAATACAAAAACATTGGAGCTAAACTTGTTCAAGATGTTGCCAATAACACAAAT
GAAGAAGCTGGGGATGGCACTACCACTGCTACTGTACTGGCACGCTCTATAGCCAAGGAAGGCTTCGAGAAGATTAGCAAAGGTGCTAAT
CCAGTGGAAATCAGGAGAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAACCTGTGACCACCCCTGAA
GAAATTGCACAGGTTGCTACGATTTCTGCAAACGGAGACAAAGAAATTGGCAATATCATCTCTGATGCAATGAAAAAAGTTGGAAGAAAG
GGTGTCATCACAGTAAAGGATGGAAAAACACTGAATGATGAATTAGAAATTATTGAAGGCATGAAGTTTGATCGAGGCTATATTTCTCCA
TACTTTATTAATACATCAAAAGGTCAGAAATGTGAATTCCAGGATGCCTATGTTCTGTTGAGTGAAAAGAAAATTTCTAGTATCCAGTCC
ATTGTACCTGCTCTTGAAATTGCCAATGCTCACCGTAAGCCTTTGGTCATAATCGCTGAAGATGTTGATGGAGAAGCTCTAAGTACACTC
GTCTTGAATAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCAAGGCTCCAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATATG
GCTATTGCTACTGGTGGTGCAGTGTTTGGAGAAGAGGGATTGACCCTGAATCTTGAAGACGTTCAGCCTCATGACTTAGGAAAAGTTGGA
GAGGTCATTGTGACCAAAGACGATGCCATGCTCTTAAAAGGAAAAGGTGACAAGGCTCAAATTGAAAAACGTATTCAAGAAATCATTGAG
CAGTTAGATGTCACAACTAGTGAATATGAAAAGGAAAAACTGAATGAACGGCTTGCAAAACTTTCAGATGGAGTGGCTGTGCTGAAGGTT
GGTGGGACAAGTGATGTTGAAGTGAATGAAAAGAAAGACAGAGTTACAGATGCCCTTAATGCTACAAGAGCTGCTGTTGAAGAAGGCATT
GTTTTGGGAGGGGGTTGTGCCCTCCTTCGATGCATTCCAGCCTTGGACTCATTGACTCCAGCTAATGAAGATCAAAAAATTGGTATAGAA
ATTATTAAAAGAACACTCAAAATTCCAGCAATGACCATTGCTAAGAATGCAGGTGTTGAAGGATCTTTGATAGTTGAGAAAATTATGCAA
AGTTCCTCAGAAGTTGGTTATGATGCTATGGCTGGAGATTTTGTGAATATGGTGGAAAAAGGAATCATTGACCCAACAAAGGTTGTGAGA
ACTGCTTTATTGGATGCTGCTGGTGTGGCCTCTCTGTTAACTACAGCAGAAGTTGTAGTCACAGAAATTCCTAAAGAAGAGAAGGACCCT
GGAATGGGTGCAATGGGTGGAATGGGAGGTGGTATGGGAGGTGGCATGTTCTAACTCCTAGACTAGTGCTTTACCTTTATTAATGAACTG
TGACAGGAAGCCCAAGGCAGTGTTCCTCACCAATAACTTCAGAGAAGTCAGTTGGAGAAAATGAAGAAAAAGGCTGGCTGAAAATCACTA
TAACCATCAGTTACTGGTTTCAGTTGACAAAATATATAATGGTTTACTGCTGTCATTGTCCATGCCTACAGATAATTTATTTTGTATTTT
TGAATAAAAAACATTTGTACATTCCTGATACTGGGTACAAGAGCCATGTACCAGTGTACTGCTTTCAACTTAAATCACTGAGGCATTTTT
ACTACTATTCTGTTAAAATCAGGATTTTAGTGCTTGCCACCACCAGATGAGAAGTTAAGCAGCCTTTCTGTGGAGAGTGAGAATAATTGT

>64537_64537_3_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000409475_HSPD1_chr2_198362116_ENST00000345042_length(amino acids)=961AA_BP=446
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKGRTV
IIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI
AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDA
YVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTL
NLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVT
DALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN

--------------------------------------------------------------
>64537_64537_4_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000409475_HSPD1_chr2_198362116_ENST00000388968_length(transcript)=3399nt_BP=1386nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGAA
CTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCCT
TTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCA
GAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAG
CAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGGTCAAGAATTTGCTCCAAAAAGTGTGGCAATAATTGGT
CATTCTATGGGTGGCCTTGTTGCAAGAGCATTGCTTACACTGAAAAATTTTAAGCATGATCTGATAAATCTTCTTATTACACAAGCCACA
CCTCATGTTGCTCCTGTGATGCCATTAGATCGTTTCATTACAGATTTTTATACGACTGTAAACAACTATTGGATTCTAAATGCTCGACAC
ATAAATTTAACCACACTTTCTGTAGCTGGAGGATTCCGGGATTACCAAGTTCGTTCAGGATTGACTTTTCTACCAAAATTAAGCCATCAT
ACCAGTGCCTTATCTGTTGTGAGTTCAGCAGTGCCTAAGACCTGGGTCTCAACAGACCACCTCTCCATTGTGTGGTGTAAACAATTGCAG
TTGACTACAGTTCGAGCATTCTTTGATCTTATTGATGCTGATACTAAACAAATAACTCAAAATTCCAAGAAGAAACTGTCAGTTTTGTAT
CACCACTTTATAAGACACCCATCAAAACATTTTGAGGAAAATCCAGCTATAATTTCTGACTTAACAGGGACATCTATGTGGGTTCTAGTA
AAAGTGTCCAAATGGACCTATGTAGCTTACAACGAATCTGAGAAGATATATTTTACATTTCCTCTTGAAAATCATAGAAAAATCTACACT
CATGTCTATTGTCAGAGCACTATGCTGGATACAAATAGTTGGATTTTTGCTTGCATAAACAGCACTTCTATGTGCCTGCAAGGGGTTGAT
TTATCATGGAAAGCTGAACTGCTGCCAACAATTAAGGGAAGAACAGTGATTATTGAGCAGAGTTGGGGAAGTCCCAAAGTAACAAAAGAT
GGTGTGACTGTTGCAAAGTCAATTGACTTAAAAGATAAATACAAAAACATTGGAGCTAAACTTGTTCAAGATGTTGCCAATAACACAAAT
GAAGAAGCTGGGGATGGCACTACCACTGCTACTGTACTGGCACGCTCTATAGCCAAGGAAGGCTTCGAGAAGATTAGCAAAGGTGCTAAT
CCAGTGGAAATCAGGAGAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAACCTGTGACCACCCCTGAA
GAAATTGCACAGGTTGCTACGATTTCTGCAAACGGAGACAAAGAAATTGGCAATATCATCTCTGATGCAATGAAAAAAGTTGGAAGAAAG
GGTGTCATCACAGTAAAGGATGGAAAAACACTGAATGATGAATTAGAAATTATTGAAGGCATGAAGTTTGATCGAGGCTATATTTCTCCA
TACTTTATTAATACATCAAAAGGTCAGAAATGTGAATTCCAGGATGCCTATGTTCTGTTGAGTGAAAAGAAAATTTCTAGTATCCAGTCC
ATTGTACCTGCTCTTGAAATTGCCAATGCTCACCGTAAGCCTTTGGTCATAATCGCTGAAGATGTTGATGGAGAAGCTCTAAGTACACTC
GTCTTGAATAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCAAGGCTCCAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATATG
GCTATTGCTACTGGTGGTGCAGTGTTTGGAGAAGAGGGATTGACCCTGAATCTTGAAGACGTTCAGCCTCATGACTTAGGAAAAGTTGGA
GAGGTCATTGTGACCAAAGACGATGCCATGCTCTTAAAAGGAAAAGGTGACAAGGCTCAAATTGAAAAACGTATTCAAGAAATCATTGAG
CAGTTAGATGTCACAACTAGTGAATATGAAAAGGAAAAACTGAATGAACGGCTTGCAAAACTTTCAGATGGAGTGGCTGTGCTGAAGGTT
GGTGGGACAAGTGATGTTGAAGTGAATGAAAAGAAAGACAGAGTTACAGATGCCCTTAATGCTACAAGAGCTGCTGTTGAAGAAGGCATT
GTTTTGGGAGGGGGTTGTGCCCTCCTTCGATGCATTCCAGCCTTGGACTCATTGACTCCAGCTAATGAAGATCAAAAAATTGGTATAGAA
ATTATTAAAAGAACACTCAAAATTCCAGCAATGACCATTGCTAAGAATGCAGGTGTTGAAGGATCTTTGATAGTTGAGAAAATTATGCAA
AGTTCCTCAGAAGTTGGTTATGATGCTATGGCTGGAGATTTTGTGAATATGGTGGAAAAAGGAATCATTGACCCAACAAAGGTTGTGAGA
ACTGCTTTATTGGATGCTGCTGGTGTGGCCTCTCTGTTAACTACAGCAGAAGTTGTAGTCACAGAAATTCCTAAAGAAGAGAAGGACCCT
GGAATGGGTGCAATGGGTGGAATGGGAGGTGGTATGGGAGGTGGCATGTTCTAACTCCTAGACTAGTGCTTTACCTTTATTAATGAACTG
TGACAGGAAGCCCAAGGCAGTGTTCCTCACCAATAACTTCAGAGAAGTCAGTTGGAGAAAATGAAGAAAAAGGCTGGCTGAAAATCACTA
TAACCATCAGTTACTGGTTTCAGTTGACAAAATATATAATGGTTTACTGCTGTCATTGTCCATGCCTACAGATAATTTATTTTGTATTTT
TGAATAAAAAACATTTGTACATTCCTGATACTGGGTACAAGAGCCATGTACCAGTGTACTGCTTTCAACTTAAATCACTGAGGCATTTTT
ACTACTATTCTGTTAAAATCAGGATTTTAGTGCTTGCCACCACCAGATGAGAAGTTAAGCAGCCTTTCTGTGGAGAGTGAGAATAATTGT

>64537_64537_4_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000409475_HSPD1_chr2_198362116_ENST00000388968_length(amino acids)=961AA_BP=446
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKGRTV
IIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI
AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDA
YVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTL
NLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVT
DALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PGAP1-HSPD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PGAP1-HSPD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PGAP1-HSPD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source