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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGAP1-NCKAP5 (FusionGDB2 ID:64538)

Fusion Gene Summary for PGAP1-NCKAP5

check button Fusion gene summary
Fusion gene informationFusion gene name: PGAP1-NCKAP5
Fusion gene ID: 64538
HgeneTgene
Gene symbol

PGAP1

NCKAP5

Gene ID

80055

344148

Gene namepost-GPI attachment to proteins inositol deacylase 1NCK associated protein 5
SynonymsBst1|ISPD3024|MRT42|SPG67ERIH1|ERIH2|NAP5
Cytomap

2q33.1

2q21.2

Type of geneprotein-codingprotein-coding
DescriptionGPI inositol-deacylasepost-GPI attachment to proteins 1post-GPI attachment to proteins factor 1nck-associated protein 5NAP-5peripheral clock protein 2
Modification date2020031320200313
UniProtAcc.

Q9HCH0

Ensembl transtripts involved in fusion geneENST00000354764, ENST00000409475, 
ENST00000409188, ENST00000485830, 
ENST00000473859, ENST00000317721, 
ENST00000405974, ENST00000409213, 
ENST00000409261, 
Fusion gene scores* DoF score9 X 12 X 7=75614 X 14 X 5=980
# samples 1015
** MAII scorelog2(10/756*10)=-2.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/980*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGAP1 [Title/Abstract] AND NCKAP5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGAP1(197791194)-NCKAP5(133430878), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCKAP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-1070-01APGAP1chr2

197791194

-NCKAP5chr2

133430878

-
ChimerDB4LUSCTCGA-21-1070PGAP1chr2

197791194

-NCKAP5chr2

133430878

-


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Fusion Gene ORF analysis for PGAP1-NCKAP5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000354764ENST00000473859PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
5CDS-intronENST00000409475ENST00000473859PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
In-frameENST00000354764ENST00000317721PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
In-frameENST00000354764ENST00000405974PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
In-frameENST00000354764ENST00000409213PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
In-frameENST00000354764ENST00000409261PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
In-frameENST00000409475ENST00000317721PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
In-frameENST00000409475ENST00000405974PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
In-frameENST00000409475ENST00000409213PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
In-frameENST00000409475ENST00000409261PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-3CDSENST00000409188ENST00000317721PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-3CDSENST00000409188ENST00000405974PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-3CDSENST00000409188ENST00000409213PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-3CDSENST00000409188ENST00000409261PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-3CDSENST00000485830ENST00000317721PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-3CDSENST00000485830ENST00000405974PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-3CDSENST00000485830ENST00000409213PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-3CDSENST00000485830ENST00000409261PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-intronENST00000409188ENST00000473859PGAP1chr2

197791194

-NCKAP5chr2

133430878

-
intron-intronENST00000485830ENST00000473859PGAP1chr2

197791194

-NCKAP5chr2

133430878

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354764PGAP1chr2197791194-ENST00000409261NCKAP5chr2133430878-176726249543164
ENST00000354764PGAP1chr2197791194-ENST00000409213NCKAP5chr2133430878-51926249516156
ENST00000354764PGAP1chr2197791194-ENST00000405974NCKAP5chr2133430878-2792624927676
ENST00000354764PGAP1chr2197791194-ENST00000317721NCKAP5chr2133430878-2792624927676
ENST00000409475PGAP1chr2197791194-ENST00000409261NCKAP5chr2133430878-176626148542164
ENST00000409475PGAP1chr2197791194-ENST00000409213NCKAP5chr2133430878-51826148515156
ENST00000409475PGAP1chr2197791194-ENST00000405974NCKAP5chr2133430878-2782614827576
ENST00000409475PGAP1chr2197791194-ENST00000317721NCKAP5chr2133430878-2782614827576

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354764ENST00000409261PGAP1chr2197791194-NCKAP5chr2133430878-0.0042318210.9957682
ENST00000354764ENST00000409213PGAP1chr2197791194-NCKAP5chr2133430878-0.78117980.21882017
ENST00000354764ENST00000405974PGAP1chr2197791194-NCKAP5chr2133430878-0.753352340.24664766
ENST00000354764ENST00000317721PGAP1chr2197791194-NCKAP5chr2133430878-0.753352340.24664766
ENST00000409475ENST00000409261PGAP1chr2197791194-NCKAP5chr2133430878-0.003394310.99660563
ENST00000409475ENST00000409213PGAP1chr2197791194-NCKAP5chr2133430878-0.78268570.21731432
ENST00000409475ENST00000405974PGAP1chr2197791194-NCKAP5chr2133430878-0.75470830.24529175
ENST00000409475ENST00000317721PGAP1chr2197791194-NCKAP5chr2133430878-0.75470830.24529175

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Fusion Genomic Features for PGAP1-NCKAP5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGAP1-NCKAP5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:197791194/chr2:133430878)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NCKAP5

Q9HCH0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-1271_1149923.0Topological domainCytoplasmic
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-1201_1149593.0Topological domainCytoplasmic
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-12712_3249923.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-12012_3249593.0TransmembraneHelical
TgeneNCKAP5chr2:197791194chr2:133430878ENST0000040597414161080_1130585591.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr2:197791194chr2:133430878ENST000004059741416927_933585591.0Compositional biasNote=Poly-Pro
TgeneNCKAP5chr2:197791194chr2:133430878ENST0000040921316181080_1130585591.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr2:197791194chr2:133430878ENST000004092131618927_933585591.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-12733_64149923.0Topological domainLumenal
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127663_66849923.0Topological domainCytoplasmic
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127690_73349923.0Topological domainLumenal
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127755_81749923.0Topological domainCytoplasmic
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127839_85349923.0Topological domainLumenal
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127875_89349923.0Topological domainCytoplasmic
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127915_92249923.0Topological domainLumenal
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-12033_64149593.0Topological domainLumenal
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120663_66849593.0Topological domainCytoplasmic
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120690_73349593.0Topological domainLumenal
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120755_81749593.0Topological domainCytoplasmic
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120839_85349593.0Topological domainLumenal
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120875_89349593.0Topological domainCytoplasmic
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120915_92249593.0Topological domainLumenal
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127642_66249923.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127669_68949923.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127734_75449923.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127818_83849923.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127854_87449923.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000354764-127894_91449923.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120642_66249593.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120669_68949593.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120734_75449593.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120818_83849593.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120854_87449593.0TransmembraneHelical
HgenePGAP1chr2:197791194chr2:133430878ENST00000409475-120894_91449593.0TransmembraneHelical
TgeneNCKAP5chr2:197791194chr2:133430878ENST00000317721161871_25319041910.0Coiled coilOntology_term=ECO:0000255
TgeneNCKAP5chr2:197791194chr2:133430878ENST00000405974141671_253585591.0Coiled coilOntology_term=ECO:0000255
TgeneNCKAP5chr2:197791194chr2:133430878ENST00000409213161871_253585591.0Coiled coilOntology_term=ECO:0000255
TgeneNCKAP5chr2:197791194chr2:133430878ENST00000409261182071_25319041910.0Coiled coilOntology_term=ECO:0000255
TgeneNCKAP5chr2:197791194chr2:133430878ENST0000031772116181080_113019041910.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr2:197791194chr2:133430878ENST000003177211618331_38619041910.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr2:197791194chr2:133430878ENST000003177211618927_93319041910.0Compositional biasNote=Poly-Pro
TgeneNCKAP5chr2:197791194chr2:133430878ENST000004059741416331_386585591.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr2:197791194chr2:133430878ENST000004092131618331_386585591.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr2:197791194chr2:133430878ENST0000040926118201080_113019041910.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr2:197791194chr2:133430878ENST000004092611820331_38619041910.0Compositional biasNote=Ser-rich
TgeneNCKAP5chr2:197791194chr2:133430878ENST000004092611820927_93319041910.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for PGAP1-NCKAP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64538_64538_1_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000354764_NCKAP5_chr2_133430878_ENST00000317721_length(transcript)=279nt_BP=262nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAATTGAG

>64538_64538_1_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000354764_NCKAP5_chr2_133430878_ENST00000317721_length(amino acids)=76AA_BP=

--------------------------------------------------------------
>64538_64538_2_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000354764_NCKAP5_chr2_133430878_ENST00000405974_length(transcript)=279nt_BP=262nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAATTGAG

>64538_64538_2_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000354764_NCKAP5_chr2_133430878_ENST00000405974_length(amino acids)=76AA_BP=

--------------------------------------------------------------
>64538_64538_3_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000354764_NCKAP5_chr2_133430878_ENST00000409213_length(transcript)=519nt_BP=262nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAATTGAG
ACAACTTGAAGAAACAAAAGACGATCCCGAGAATAGATTATCGAAAATTTCCCTAGAGTCATTCAATAAATTTAACAGCAATACTGTGAT
TTTATTAGAAAAAGAGAAGAACTCTCTGAACAAGGTTGAAGGACAGAAGGAAGAAAAAGAAAAAAATGAAGAGACATCTTTGAGTAGTTC

>64538_64538_3_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000354764_NCKAP5_chr2_133430878_ENST00000409213_length(amino acids)=156AA_BP=70
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKLRQLEETKDDPENRLSKI

--------------------------------------------------------------
>64538_64538_4_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000354764_NCKAP5_chr2_133430878_ENST00000409261_length(transcript)=1767nt_BP=262nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAATTGAG
ACAACTTGAAGAAACAAAAGACGATCCCGAGAATAGATTATCGAAAATTTCCCTAGAGTCATTCAATAAATTTAACAGCAATACTGTGAT
TTTATTAGAAAAAGAGAAGAACTCTCTGAACAAGGTTGAAGGACAGAAGGAAGAAAAAGAAAAAAATGAAGAGACATCTTTGAGTAGTTC
AGATAGGCCTGGGGTAGACAACTTGGAATCTTTGAGTGATTCTTTATATGATAGCTTCTCTTCCTGTGCCAGTCAAGGTTCAAATGATGT
ATAAAGGACATCTCTTCCCTTAGTGAGCTGGGACTGGAGCGCTTAAGAAATGATGGGTGGGGGGTGGGGGGTGCACCGCTTGATAGAGAT
AACAATAAACTATTGCAGTACCAGAGCCTTCCTTGTCAAATTCACAGCAGGCAACCCACCAGAGCTTATTTCTCTGACAGGGCAATAAAG
ATAGACTCCATTTATTGTGTTTCAAGAGGATTAAGCGTAAACACATCTATGATACAGAATCCTTAATTTTGCACTTTTTTTGAATATTTG
TACAGAAGTTGTAAATTTTTTGGAAGAGAAATTATATTTGTAGCAAAAAAAGACAGCAATAAATGGAATCAGTGCCATGCTCTTGAAATA
ATGTACTAAGTCTTAGAAGTTGATGATAATATATATTTTTTAAAATCCCAACTGAAGTTTTTGTGAAGTTCGTTGTCCTGGTCCTCAAAT
TGTTTGTGGGTACACTCTGTAAACCTACAACAGGGCCTGCCAAAAAATCGGAGGGTTCCTCCTCATCTCCATCTCACAAATCTCAATTTG
ATGGAAATGTTCATTTTAGTGTAATTTCAGATTCGTTGCCAGAGATTCAGGTGATAGTAATAAGTGTCATTCTGCTTCTGCTGAAAAATG
AAAAGGGTCCTGAAGTGTGGACACTGATTGGGAGTGTGACATTGTATCAGAAATGACCGAATTCTATTCCCAATACCAGTTTTTCCTTCC
AGACATTTCTTTAGATTGTCTTTTACTTAGTGCTTCTCTATGATCCTGAATATTATTTGATTTTTATCTTCTTGCTCTTTTTATTAAAAT
CTGGGCACTCTAAAAATGAAAACAAATTTCTATTTGCAATGTTCACTTTTAAAAATAAAATTAATGGTGCTACGAAGAATTCTTTTTAAT
ATCCTTTTTTTTCTACAAAGACTGTTTATATGTAAGGATAAATTCTATTTTAAAGGTTATGTGTATTTTTTCTAGATGTGAACTATTTAT
AATTACTTATGTACAGGAGCTTGTAAACTAGGCCCAATAGAAATATTTTTAGGATCTATATGGCTACTTTAGCACATAATTGTTTCTTTA
AAGAGTATTGTATGATCAGTGTTATTTGGTTAATTTGTGCAATTTGTTTTATTTTATCTTAAATGAAAATTATGTAAAATGTCCTTGTCT

>64538_64538_4_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000354764_NCKAP5_chr2_133430878_ENST00000409261_length(amino acids)=164AA_BP=70
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKLRQLEETKDDPENRLSKI

--------------------------------------------------------------
>64538_64538_5_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000409475_NCKAP5_chr2_133430878_ENST00000317721_length(transcript)=278nt_BP=261nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAATTGAGA

>64538_64538_5_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000409475_NCKAP5_chr2_133430878_ENST00000317721_length(amino acids)=76AA_BP=

--------------------------------------------------------------
>64538_64538_6_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000409475_NCKAP5_chr2_133430878_ENST00000405974_length(transcript)=278nt_BP=261nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAATTGAGA

>64538_64538_6_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000409475_NCKAP5_chr2_133430878_ENST00000405974_length(amino acids)=76AA_BP=

--------------------------------------------------------------
>64538_64538_7_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000409475_NCKAP5_chr2_133430878_ENST00000409213_length(transcript)=518nt_BP=261nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAATTGAGA
CAACTTGAAGAAACAAAAGACGATCCCGAGAATAGATTATCGAAAATTTCCCTAGAGTCATTCAATAAATTTAACAGCAATACTGTGATT
TTATTAGAAAAAGAGAAGAACTCTCTGAACAAGGTTGAAGGACAGAAGGAAGAAAAAGAAAAAAATGAAGAGACATCTTTGAGTAGTTCA

>64538_64538_7_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000409475_NCKAP5_chr2_133430878_ENST00000409213_length(amino acids)=156AA_BP=70
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKLRQLEETKDDPENRLSKI

--------------------------------------------------------------
>64538_64538_8_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000409475_NCKAP5_chr2_133430878_ENST00000409261_length(transcript)=1766nt_BP=261nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAATTGAGA
CAACTTGAAGAAACAAAAGACGATCCCGAGAATAGATTATCGAAAATTTCCCTAGAGTCATTCAATAAATTTAACAGCAATACTGTGATT
TTATTAGAAAAAGAGAAGAACTCTCTGAACAAGGTTGAAGGACAGAAGGAAGAAAAAGAAAAAAATGAAGAGACATCTTTGAGTAGTTCA
GATAGGCCTGGGGTAGACAACTTGGAATCTTTGAGTGATTCTTTATATGATAGCTTCTCTTCCTGTGCCAGTCAAGGTTCAAATGATGTA
TAAAGGACATCTCTTCCCTTAGTGAGCTGGGACTGGAGCGCTTAAGAAATGATGGGTGGGGGGTGGGGGGTGCACCGCTTGATAGAGATA
ACAATAAACTATTGCAGTACCAGAGCCTTCCTTGTCAAATTCACAGCAGGCAACCCACCAGAGCTTATTTCTCTGACAGGGCAATAAAGA
TAGACTCCATTTATTGTGTTTCAAGAGGATTAAGCGTAAACACATCTATGATACAGAATCCTTAATTTTGCACTTTTTTTGAATATTTGT
ACAGAAGTTGTAAATTTTTTGGAAGAGAAATTATATTTGTAGCAAAAAAAGACAGCAATAAATGGAATCAGTGCCATGCTCTTGAAATAA
TGTACTAAGTCTTAGAAGTTGATGATAATATATATTTTTTAAAATCCCAACTGAAGTTTTTGTGAAGTTCGTTGTCCTGGTCCTCAAATT
GTTTGTGGGTACACTCTGTAAACCTACAACAGGGCCTGCCAAAAAATCGGAGGGTTCCTCCTCATCTCCATCTCACAAATCTCAATTTGA
TGGAAATGTTCATTTTAGTGTAATTTCAGATTCGTTGCCAGAGATTCAGGTGATAGTAATAAGTGTCATTCTGCTTCTGCTGAAAAATGA
AAAGGGTCCTGAAGTGTGGACACTGATTGGGAGTGTGACATTGTATCAGAAATGACCGAATTCTATTCCCAATACCAGTTTTTCCTTCCA
GACATTTCTTTAGATTGTCTTTTACTTAGTGCTTCTCTATGATCCTGAATATTATTTGATTTTTATCTTCTTGCTCTTTTTATTAAAATC
TGGGCACTCTAAAAATGAAAACAAATTTCTATTTGCAATGTTCACTTTTAAAAATAAAATTAATGGTGCTACGAAGAATTCTTTTTAATA
TCCTTTTTTTTCTACAAAGACTGTTTATATGTAAGGATAAATTCTATTTTAAAGGTTATGTGTATTTTTTCTAGATGTGAACTATTTATA
ATTACTTATGTACAGGAGCTTGTAAACTAGGCCCAATAGAAATATTTTTAGGATCTATATGGCTACTTTAGCACATAATTGTTTCTTTAA
AGAGTATTGTATGATCAGTGTTATTTGGTTAATTTGTGCAATTTGTTTTATTTTATCTTAAATGAAAATTATGTAAAATGTCCTTGTCTT

>64538_64538_8_PGAP1-NCKAP5_PGAP1_chr2_197791194_ENST00000409475_NCKAP5_chr2_133430878_ENST00000409261_length(amino acids)=164AA_BP=70
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKLRQLEETKDDPENRLSKI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGAP1-NCKAP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGAP1-NCKAP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGAP1-NCKAP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource