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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PGAP1-SPAG16 (FusionGDB2 ID:64539)

Fusion Gene Summary for PGAP1-SPAG16

Fusion gene summary

Fusion gene information	Fusion gene name: PGAP1-SPAG16
	Fusion gene ID: 64539
		Hgene	Tgene
	Gene symbol	PGAP1	SPAG16
	Gene ID	80055	79582
	Gene name	post-GPI attachment to proteins inositol deacylase 1	sperm associated antigen 16
	Synonyms	Bst1\|ISPD3024\|MRT42\|SPG67	PF20\|WDR29
	Cytomap	2q33.1	2q34
	Type of gene	protein-coding	protein-coding
	Description	GPI inositol-deacylasepost-GPI attachment to proteins 1post-GPI attachment to proteins factor 1	sperm-associated antigen 16 proteinWD repeat domain 29pf20 protein homologsperm-associated WD repeat protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000354764, ENST00000409188, ENST00000409475, ENST00000485830,	ENST00000272898, ENST00000331683, ENST00000374309, ENST00000413312, ENST00000414961, ENST00000432529, ENST00000447990,
Fusion gene scores	* DoF score	9 X 12 X 7=756	16 X 16 X 8=2048
	# samples	10	18
	** MAII score	log2(10/756*10)=-2.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/2048*10)=-3.50814690367033 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PGAP1 [Title/Abstract] AND SPAG16 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PGAP1(197781142)-SPAG16(215274864), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPAG16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A228-01A	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
ChimerDB4	BRCA	TCGA-E9-A228-01A	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
ChimerDB4	BRCA	TCGA-E9-A228-01A	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
ChimerDB4	BRCA	TCGA-E9-A228-01A	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
ChimerDB4	BRCA	TCGA-E9-A228-01A	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
ChimerDB4	BRCA	TCGA-E9-A228	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+

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Fusion Gene ORF analysis for PGAP1-SPAG16

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000354764	ENST00000272898	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000354764	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000354764	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000272898	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000354764	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000354764	ENST00000331683	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000354764	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000354764	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000374309	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000354764	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000354764	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000413312	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000354764	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000354764	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000413312	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000354764	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000354764	ENST00000414961	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000354764	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000354764	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000414961	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000354764	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000354764	ENST00000432529	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000354764	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000354764	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000432529	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000354764	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000354764	ENST00000447990	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000354764	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000354764	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000354764	ENST00000447990	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000354764	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409188	ENST00000272898	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409188	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409188	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000272898	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409188	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409188	ENST00000331683	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409188	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409188	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000374309	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409188	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409188	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000413312	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409188	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409188	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000413312	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409188	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409188	ENST00000414961	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409188	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409188	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000414961	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409188	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409188	ENST00000432529	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409188	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409188	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000432529	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409188	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409188	ENST00000447990	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409188	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409188	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409188	ENST00000447990	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409188	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409475	ENST00000272898	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409475	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409475	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000272898	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409475	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409475	ENST00000331683	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409475	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409475	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000374309	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409475	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409475	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000413312	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409475	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409475	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000413312	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409475	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409475	ENST00000414961	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409475	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409475	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000414961	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409475	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409475	ENST00000432529	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409475	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409475	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000432529	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409475	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5CDS-intron	ENST00000409475	ENST00000447990	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5CDS-intron	ENST00000409475	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5CDS-intron	ENST00000409475	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5CDS-intron	ENST00000409475	ENST00000447990	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5CDS-intron	ENST00000409475	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5UTR-3CDS	ENST00000485830	ENST00000331683	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5UTR-3CDS	ENST00000485830	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5UTR-3CDS	ENST00000485830	ENST00000374309	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5UTR-3CDS	ENST00000485830	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5UTR-intron	ENST00000485830	ENST00000272898	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5UTR-intron	ENST00000485830	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5UTR-intron	ENST00000485830	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000272898	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5UTR-intron	ENST00000485830	ENST00000272898	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5UTR-intron	ENST00000485830	ENST00000331683	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5UTR-intron	ENST00000485830	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5UTR-intron	ENST00000485830	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000374309	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5UTR-intron	ENST00000485830	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5UTR-intron	ENST00000485830	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000413312	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5UTR-intron	ENST00000485830	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5UTR-intron	ENST00000485830	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000413312	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5UTR-intron	ENST00000485830	ENST00000413312	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5UTR-intron	ENST00000485830	ENST00000414961	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5UTR-intron	ENST00000485830	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5UTR-intron	ENST00000485830	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000414961	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5UTR-intron	ENST00000485830	ENST00000414961	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5UTR-intron	ENST00000485830	ENST00000432529	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5UTR-intron	ENST00000485830	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5UTR-intron	ENST00000485830	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000432529	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5UTR-intron	ENST00000485830	ENST00000432529	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
5UTR-intron	ENST00000485830	ENST00000447990	PGAP1	chr2	197781140	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215195227	-
5UTR-intron	ENST00000485830	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215197614	-
5UTR-intron	ENST00000485830	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215198510	-
5UTR-intron	ENST00000485830	ENST00000447990	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
5UTR-intron	ENST00000485830	ENST00000447990	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
In-frame	ENST00000354764	ENST00000331683	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
In-frame	ENST00000354764	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
In-frame	ENST00000354764	ENST00000374309	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
In-frame	ENST00000354764	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
In-frame	ENST00000409188	ENST00000331683	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
In-frame	ENST00000409188	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
In-frame	ENST00000409188	ENST00000374309	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
In-frame	ENST00000409188	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
In-frame	ENST00000409475	ENST00000331683	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
In-frame	ENST00000409475	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+
In-frame	ENST00000409475	ENST00000374309	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+
In-frame	ENST00000409475	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000354764	PGAP1	chr2	197781142	-	ENST00000331683	SPAG16	chr2	215274864	+	954	592	49	603	184
ENST00000354764	PGAP1	chr2	197781142	-	ENST00000374309	SPAG16	chr2	215274864	+	768	592	49	603	184
ENST00000409475	PGAP1	chr2	197781142	-	ENST00000331683	SPAG16	chr2	215274864	+	953	591	48	602	184
ENST00000409475	PGAP1	chr2	197781142	-	ENST00000374309	SPAG16	chr2	215274864	+	767	591	48	602	184
ENST00000409188	PGAP1	chr2	197781142	-	ENST00000331683	SPAG16	chr2	215274864	+	898	536	125	547	140
ENST00000409188	PGAP1	chr2	197781142	-	ENST00000374309	SPAG16	chr2	215274864	+	712	536	125	547	140
ENST00000354764	PGAP1	chr2	197781141	-	ENST00000331683	SPAG16	chr2	215274863	+	954	592	49	603	184
ENST00000354764	PGAP1	chr2	197781141	-	ENST00000374309	SPAG16	chr2	215274863	+	768	592	49	603	184
ENST00000409475	PGAP1	chr2	197781141	-	ENST00000331683	SPAG16	chr2	215274863	+	953	591	48	602	184
ENST00000409475	PGAP1	chr2	197781141	-	ENST00000374309	SPAG16	chr2	215274863	+	767	591	48	602	184
ENST00000409188	PGAP1	chr2	197781141	-	ENST00000331683	SPAG16	chr2	215274863	+	898	536	125	547	140
ENST00000409188	PGAP1	chr2	197781141	-	ENST00000374309	SPAG16	chr2	215274863	+	712	536	125	547	140

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000354764	ENST00000331683	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+	0.002742038	0.99725795
ENST00000354764	ENST00000374309	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+	0.002228961	0.997771
ENST00000409475	ENST00000331683	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+	0.002663327	0.9973367
ENST00000409475	ENST00000374309	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+	0.002138181	0.9978618
ENST00000409188	ENST00000331683	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+	0.010562407	0.9894376
ENST00000409188	ENST00000374309	PGAP1	chr2	197781142	-	SPAG16	chr2	215274864	+	0.010268984	0.9897311
ENST00000354764	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.002742038	0.99725795
ENST00000354764	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.002228961	0.997771
ENST00000409475	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.002663327	0.9973367
ENST00000409475	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.002138181	0.9978618
ENST00000409188	ENST00000331683	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.010562407	0.9894376
ENST00000409188	ENST00000374309	PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.010268984	0.9897311

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Fusion Genomic Features for PGAP1-SPAG16

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.000265878	0.9997341
PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.000265878	0.9997341
PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.000265878	0.9997341
PGAP1	chr2	197781141	-	SPAG16	chr2	215274863	+	0.000265878	0.9997341

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGAP1-SPAG16

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:197781142/chr2:215274864)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

1_11

159

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

1_11

159

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

1_11

159

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

1_11

159

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

12_32

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

12_32

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

12_32

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

12_32

159

593.0

Transmembrane

Helical

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000272898

152_267

348.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000413312

152_267

252.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000432529

152_267

184.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000272898

152_267

348.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000413312

152_267

252.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000432529

152_267

184.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000272898

350_389

348.0

Repeat

Note=WD 1

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000272898

392_431

348.0

Repeat

Note=WD 2

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000272898

434_473

348.0

Repeat

Note=WD 3

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000272898

476_515

348.0

Repeat

Note=WD 4

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000272898

518_557

348.0

Repeat

Note=WD 5

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000272898

560_600

348.0

Repeat

Note=WD 6

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000272898

601_630

348.0

Repeat

Note=WD 7

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000331683

601_630

573

632.0

Repeat

Note=WD 7

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000413312

350_389

252.0

Repeat

Note=WD 1

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000413312

392_431

252.0

Repeat

Note=WD 2

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000413312

434_473

252.0

Repeat

Note=WD 3

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000413312

476_515

252.0

Repeat

Note=WD 4

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000413312

518_557

252.0

Repeat

Note=WD 5

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000413312

560_600

252.0

Repeat

Note=WD 6

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000413312

601_630

252.0

Repeat

Note=WD 7

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000432529

350_389

184.0

Repeat

Note=WD 1

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000432529

392_431

184.0

Repeat

Note=WD 2

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000432529

434_473

184.0

Repeat

Note=WD 3

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000432529

476_515

184.0

Repeat

Note=WD 4

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000432529

518_557

184.0

Repeat

Note=WD 5

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000432529

560_600

184.0

Repeat

Note=WD 6

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000432529

601_630

184.0

Repeat

Note=WD 7

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000272898

350_389

348.0

Repeat

Note=WD 1

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000272898

392_431

348.0

Repeat

Note=WD 2

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000272898

434_473

348.0

Repeat

Note=WD 3

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000272898

476_515

348.0

Repeat

Note=WD 4

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000272898

518_557

348.0

Repeat

Note=WD 5

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000272898

560_600

348.0

Repeat

Note=WD 6

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000272898

601_630

348.0

Repeat

Note=WD 7

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000331683

601_630

573

632.0

Repeat

Note=WD 7

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000413312

350_389

252.0

Repeat

Note=WD 1

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000413312

392_431

252.0

Repeat

Note=WD 2

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000413312

434_473

252.0

Repeat

Note=WD 3

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000413312

476_515

252.0

Repeat

Note=WD 4

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000413312

518_557

252.0

Repeat

Note=WD 5

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000413312

560_600

252.0

Repeat

Note=WD 6

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000413312

601_630

252.0

Repeat

Note=WD 7

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000432529

350_389

184.0

Repeat

Note=WD 1

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000432529

392_431

184.0

Repeat

Note=WD 2

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000432529

434_473

184.0

Repeat

Note=WD 3

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000432529

476_515

184.0

Repeat

Note=WD 4

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000432529

518_557

184.0

Repeat

Note=WD 5

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000432529

560_600

184.0

Repeat

Note=WD 6

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000432529

601_630

184.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

33_641

159

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

663_668

159

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

690_733

159

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

755_817

159

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

839_853

159

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

875_893

159

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

915_922

159

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

33_641

159

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

663_668

159

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

690_733

159

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

755_817

159

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

839_853

159

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

875_893

159

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

915_922

159

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

33_641

159

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

663_668

159

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

690_733

159

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

755_817

159

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

839_853

159

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

875_893

159

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

915_922

159

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

33_641

159

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

663_668

159

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

690_733

159

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

755_817

159

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

839_853

159

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

875_893

159

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

915_922

159

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

642_662

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

669_689

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

734_754

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

818_838

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

854_874

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000354764

894_914

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

642_662

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

669_689

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

734_754

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

818_838

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

854_874

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781141

chr2:215274863

ENST00000409475

894_914

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

642_662

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

669_689

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

734_754

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

818_838

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

854_874

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000354764

894_914

159

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

642_662

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

669_689

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

734_754

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

818_838

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

854_874

159

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197781142

chr2:215274864

ENST00000409475

894_914

159

593.0

Transmembrane

Helical

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000331683

152_267

573

632.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000331683

152_267

573

632.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000331683

350_389

573

632.0

Repeat

Note=WD 1

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000331683

392_431

573

632.0

Repeat

Note=WD 2

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000331683

434_473

573

632.0

Repeat

Note=WD 3

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000331683

476_515

573

632.0

Repeat

Note=WD 4

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000331683

518_557

573

632.0

Repeat

Note=WD 5

Tgene

SPAG16

chr2:197781141

chr2:215274863

ENST00000331683

560_600

573

632.0

Repeat

Note=WD 6

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000331683

350_389

573

632.0

Repeat

Note=WD 1

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000331683

392_431

573

632.0

Repeat

Note=WD 2

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000331683

434_473

573

632.0

Repeat

Note=WD 3

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000331683

476_515

573

632.0

Repeat

Note=WD 4

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000331683

518_557

573

632.0

Repeat

Note=WD 5

Tgene

SPAG16

chr2:197781142

chr2:215274864

ENST00000331683

560_600

573

632.0

Repeat

Note=WD 6

Top

Fusion Gene Sequence for PGAP1-SPAG16

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64539_64539_1_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000354764_SPAG16_chr2_215274863_ENST00000331683_length(transcript)=954nt_BP=592nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGA
ACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCC
TTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGC
AGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAA
GCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATC
CATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAG
ATTCTCTTTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGCACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCT
TGAAAATGCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAGGTAACATTTACAGTCTGCTTTAAAACATGCTTTG

>64539_64539_1_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000354764_SPAG16_chr2_215274863_ENST00000331683_length(amino acids)=184AA_BP=
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY

--------------------------------------------------------------
>64539_64539_2_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000354764_SPAG16_chr2_215274863_ENST00000374309_length(transcript)=768nt_BP=592nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGA
ACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCC
TTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGC
AGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAA
GCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATC
CATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAG

>64539_64539_2_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000354764_SPAG16_chr2_215274863_ENST00000374309_length(amino acids)=184AA_BP=
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY

--------------------------------------------------------------
>64539_64539_3_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000409188_SPAG16_chr2_215274863_ENST00000331683_length(transcript)=898nt_BP=536nt
TTTTTCCTAACATTCTAGTGTTTTGAAGCTGCTACAAGTGATTGATTTCGAGCTTTTTTTAAAAACTCCTCCTTTGTACAAAACAGAACC
GAAATTCTTCAAAACGAATTAAGTCATTTGCGAGTTTGAATGGAAGCTGGACGAAATTGCCTCCTCCAGTTAACGTGGAACCCATTCCCC
AAGAGATGGAGGTTCTGGAGAGCAAGAAAATAGAACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAG
AGGGATCCTATGCTGAAGAACACAAAATTCTCCCTTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAG
TTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCAGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAG
AACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAGCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCG
AGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGA
GGCACACACGGTTGTGTTTTCTCACGACGGGGAGATTCTCTTTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGC
ACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCTTGAAAATGCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAG

>64539_64539_3_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000409188_SPAG16_chr2_215274863_ENST00000331683_length(amino acids)=140AA_BP=
MNGSWTKLPPPVNVEPIPQEMEVLESKKIELPKKLAKRYPAYELYLYGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKA

--------------------------------------------------------------
>64539_64539_4_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000409188_SPAG16_chr2_215274863_ENST00000374309_length(transcript)=712nt_BP=536nt
TTTTTCCTAACATTCTAGTGTTTTGAAGCTGCTACAAGTGATTGATTTCGAGCTTTTTTTAAAAACTCCTCCTTTGTACAAAACAGAACC
GAAATTCTTCAAAACGAATTAAGTCATTTGCGAGTTTGAATGGAAGCTGGACGAAATTGCCTCCTCCAGTTAACGTGGAACCCATTCCCC
AAGAGATGGAGGTTCTGGAGAGCAAGAAAATAGAACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAG
AGGGATCCTATGCTGAAGAACACAAAATTCTCCCTTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAG
TTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCAGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAG
AACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAGCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCG
AGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGA

>64539_64539_4_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000409188_SPAG16_chr2_215274863_ENST00000374309_length(amino acids)=140AA_BP=
MNGSWTKLPPPVNVEPIPQEMEVLESKKIELPKKLAKRYPAYELYLYGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKA

--------------------------------------------------------------
>64539_64539_5_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000409475_SPAG16_chr2_215274863_ENST00000331683_length(transcript)=953nt_BP=591nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGAA
CTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCCT
TTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCA
GAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAG
CAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCC
ATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGA
TTCTCTTTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGCACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCTT
GAAAATGCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAGGTAACATTTACAGTCTGCTTTAAAACATGCTTTGG

>64539_64539_5_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000409475_SPAG16_chr2_215274863_ENST00000331683_length(amino acids)=184AA_BP=
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY

--------------------------------------------------------------
>64539_64539_6_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000409475_SPAG16_chr2_215274863_ENST00000374309_length(transcript)=767nt_BP=591nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGAA
CTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCCT
TTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCA
GAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAG
CAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCC
ATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGA

>64539_64539_6_PGAP1-SPAG16_PGAP1_chr2_197781141_ENST00000409475_SPAG16_chr2_215274863_ENST00000374309_length(amino acids)=184AA_BP=
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY

--------------------------------------------------------------
>64539_64539_7_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000354764_SPAG16_chr2_215274864_ENST00000331683_length(transcript)=954nt_BP=592nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGA
ACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCC
TTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGC
AGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAA
GCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATC
CATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAG
ATTCTCTTTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGCACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCT
TGAAAATGCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAGGTAACATTTACAGTCTGCTTTAAAACATGCTTTG

>64539_64539_7_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000354764_SPAG16_chr2_215274864_ENST00000331683_length(amino acids)=184AA_BP=
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY

--------------------------------------------------------------
>64539_64539_8_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000354764_SPAG16_chr2_215274864_ENST00000374309_length(transcript)=768nt_BP=592nt
CGGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGG
CGGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAAC
CCTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGA
ACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCC
TTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGC
AGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAA
GCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATC
CATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAG

>64539_64539_8_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000354764_SPAG16_chr2_215274864_ENST00000374309_length(amino acids)=184AA_BP=
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY

--------------------------------------------------------------
>64539_64539_9_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000409188_SPAG16_chr2_215274864_ENST00000331683_length(transcript)=898nt_BP=536nt
TTTTTCCTAACATTCTAGTGTTTTGAAGCTGCTACAAGTGATTGATTTCGAGCTTTTTTTAAAAACTCCTCCTTTGTACAAAACAGAACC
GAAATTCTTCAAAACGAATTAAGTCATTTGCGAGTTTGAATGGAAGCTGGACGAAATTGCCTCCTCCAGTTAACGTGGAACCCATTCCCC
AAGAGATGGAGGTTCTGGAGAGCAAGAAAATAGAACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAG
AGGGATCCTATGCTGAAGAACACAAAATTCTCCCTTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAG
TTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCAGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAG
AACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAGCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCG
AGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGA
GGCACACACGGTTGTGTTTTCTCACGACGGGGAGATTCTCTTTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGC
ACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCTTGAAAATGCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAG

>64539_64539_9_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000409188_SPAG16_chr2_215274864_ENST00000331683_length(amino acids)=140AA_BP=
MNGSWTKLPPPVNVEPIPQEMEVLESKKIELPKKLAKRYPAYELYLYGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKA

--------------------------------------------------------------
>64539_64539_10_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000409188_SPAG16_chr2_215274864_ENST00000374309_length(transcript)=712nt_BP=536nt
TTTTTCCTAACATTCTAGTGTTTTGAAGCTGCTACAAGTGATTGATTTCGAGCTTTTTTTAAAAACTCCTCCTTTGTACAAAACAGAACC
GAAATTCTTCAAAACGAATTAAGTCATTTGCGAGTTTGAATGGAAGCTGGACGAAATTGCCTCCTCCAGTTAACGTGGAACCCATTCCCC
AAGAGATGGAGGTTCTGGAGAGCAAGAAAATAGAACTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAG
AGGGATCCTATGCTGAAGAACACAAAATTCTCCCTTTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAG
TTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCAGAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAG
AACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAGCAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCG
AGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGA

>64539_64539_10_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000409188_SPAG16_chr2_215274864_ENST00000374309_length(amino acids)=140AA_BP=
MNGSWTKLPPPVNVEPIPQEMEVLESKKIELPKKLAKRYPAYELYLYGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKA

--------------------------------------------------------------
>64539_64539_11_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000409475_SPAG16_chr2_215274864_ENST00000331683_length(transcript)=953nt_BP=591nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGAA
CTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCCT
TTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCA
GAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAG
CAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCC
ATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGA
TTCTCTTTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGCACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCTT
GAAAATGCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAGGTAACATTTACAGTCTGCTTTAAAACATGCTTTGG

>64539_64539_11_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000409475_SPAG16_chr2_215274864_ENST00000331683_length(amino acids)=184AA_BP=
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY

--------------------------------------------------------------
>64539_64539_12_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000409475_SPAG16_chr2_215274864_ENST00000374309_length(transcript)=767nt_BP=591nt
GGCTCCGGGGGTGGCGGTCGGACAGTGTCTAGCACGCTCAGTCCGGGCTTGGGGCCCCGCGGCGGAGAAGGAGGTAGAGGGGGCGGCGGC
GGCGGCGGCGGTGGTGGCGGCACCATGTTTCTTCACTCAGTTAATCTCTGGAACCTGGCGTTTTATGTCTTCATGGTCTTTCTGGCAACC
CTGGGGCTGTGGGATGTCTTCTTCGGCTTCGAGGAGAATAAGTGCAGTATGAGCTACATGTTTGAGTACCCGGAGTATCAGAAAATAGAA
CTTCCAAAGAAACTGGCAAAACGCTATCCCGCATATGAGTTGTATCTTTATGGAGAGGGATCCTATGCTGAAGAACACAAAATTCTCCCT
TTGACGGGTATTCCAGTTCTCTTTCTTCCTGGTAATGCTGGAAGTTATAAGCAAGTTCGTTCTATTGGCTCCATTGCACTTAGAAAAGCA
GAGGACATTGACTTCAAGTACCACTTTGACTTCTTTAGTGTGAACTTCAATGAAGAACTGGTGGCTTTGTATGGTGGAAGTCTTCAGAAG
CAGACCAAGTTTGTACATGAATGTATTAAAACAATTCTCAAACTCTATAAGGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCC
ATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGA

>64539_64539_12_PGAP1-SPAG16_PGAP1_chr2_197781142_ENST00000409475_SPAG16_chr2_215274864_ENST00000374309_length(amino acids)=184AA_BP=
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PGAP1-SPAG16

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PGAP1-SPAG16

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PGAP1-SPAG16

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source