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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGAP3-TOP2A (FusionGDB2 ID:64564)

Fusion Gene Summary for PGAP3-TOP2A

check button Fusion gene summary
Fusion gene informationFusion gene name: PGAP3-TOP2A
Fusion gene ID: 64564
HgeneTgene
Gene symbol

PGAP3

TOP2A

Gene ID

93210

7153

Gene namepost-GPI attachment to proteins phospholipase 3DNA topoisomerase II alpha
SynonymsAGLA546|CAB2|PERLD1|PP1498|hCOS16TOP2|TP2A
Cytomap

17q12

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionpost-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1post-GPI attachment to proteins 3DNA topoisomerase 2-alphaDNA gyraseDNA topoisomerase (ATP-hydrolyzing)DNA topoisomerase II, 170 kDDNA topoisomerase II, alpha isozymetopoisomerase (DNA) II alpha 170kDa
Modification date2020032720200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000300658, ENST00000378011, 
ENST00000429199, ENST00000579146, 
ENST00000423485, 
Fusion gene scores* DoF score18 X 8 X 9=12968 X 9 X 4=288
# samples 2712
** MAII scorelog2(27/1296*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/288*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGAP3 [Title/Abstract] AND TOP2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGAP3(37844087)-TOP2A(38556915), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTOP2A

GO:0006265

DNA topological change

22323612

TgeneTOP2A

GO:0006266

DNA ligation

15491148

TgeneTOP2A

GO:0006974

cellular response to DNA damage stimulus

16611985

TgeneTOP2A

GO:0030263

apoptotic chromosome condensation

10959840

TgeneTOP2A

GO:0043065

positive regulation of apoptotic process

16611985


check buttonFusion gene breakpoints across PGAP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TOP2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8483-01APGAP3chr17

37844087

-TOP2Achr17

38556915

-
ChimerDB4STADTCGA-BR-8483PGAP3chr17

37844086

-TOP2Achr17

38556915

-


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Fusion Gene ORF analysis for PGAP3-TOP2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000300658ENST00000423485PGAP3chr17

37844087

-TOP2Achr17

38556915

-
In-frameENST00000300658ENST00000423485PGAP3chr17

37844086

-TOP2Achr17

38556915

-
In-frameENST00000378011ENST00000423485PGAP3chr17

37844087

-TOP2Achr17

38556915

-
In-frameENST00000378011ENST00000423485PGAP3chr17

37844086

-TOP2Achr17

38556915

-
In-frameENST00000429199ENST00000423485PGAP3chr17

37844087

-TOP2Achr17

38556915

-
In-frameENST00000429199ENST00000423485PGAP3chr17

37844086

-TOP2Achr17

38556915

-
In-frameENST00000579146ENST00000423485PGAP3chr17

37844087

-TOP2Achr17

38556915

-
In-frameENST00000579146ENST00000423485PGAP3chr17

37844086

-TOP2Achr17

38556915

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000579146PGAP3chr1737844087-ENST00000423485TOP2Achr1738556915-31592242632155630
ENST00000300658PGAP3chr1737844087-ENST00000423485TOP2Achr1738556915-32092743132205630
ENST00000378011PGAP3chr1737844087-ENST00000423485TOP2Achr1738556915-31592242632155630
ENST00000429199PGAP3chr1737844087-ENST00000423485TOP2Achr1738556915-31592242632155630
ENST00000579146PGAP3chr1737844086-ENST00000423485TOP2Achr1738556915-31592242632155630
ENST00000300658PGAP3chr1737844086-ENST00000423485TOP2Achr1738556915-32092743132205630
ENST00000378011PGAP3chr1737844086-ENST00000423485TOP2Achr1738556915-31592242632155630
ENST00000429199PGAP3chr1737844086-ENST00000423485TOP2Achr1738556915-31592242632155630

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000579146ENST00000423485PGAP3chr1737844087-TOP2Achr1738556915-0.0007770540.999223
ENST00000300658ENST00000423485PGAP3chr1737844087-TOP2Achr1738556915-0.0007795870.9992204
ENST00000378011ENST00000423485PGAP3chr1737844087-TOP2Achr1738556915-0.0007770540.999223
ENST00000429199ENST00000423485PGAP3chr1737844087-TOP2Achr1738556915-0.0007770540.999223
ENST00000579146ENST00000423485PGAP3chr1737844086-TOP2Achr1738556915-0.0007770540.999223
ENST00000300658ENST00000423485PGAP3chr1737844086-TOP2Achr1738556915-0.0007795870.9992204
ENST00000378011ENST00000423485PGAP3chr1737844086-TOP2Achr1738556915-0.0007770540.999223
ENST00000429199ENST00000423485PGAP3chr1737844086-TOP2Achr1738556915-0.0007770540.999223

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Fusion Genomic Features for PGAP3-TOP2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGAP3-TOP2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37844087/chr17:38556915)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTOP2Achr17:37844086chr17:38556915ENST0000042348520351018_10288881532.0MotifNote=Nuclear export signal
TgeneTOP2Achr17:37844087chr17:38556915ENST0000042348520351018_10288881532.0MotifNote=Nuclear export signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18120_13560321.0Topological domainCytoplasmic
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18157_16960321.0Topological domainLumenal
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18191_19360321.0Topological domainCytoplasmic
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18215_22460321.0Topological domainLumenal
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-1821_9860321.0Topological domainLumenal
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18246_25760321.0Topological domainCytoplasmic
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18279_27960321.0Topological domainLumenal
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18300_32060321.0Topological domainCytoplasmic
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17120_13560270.0Topological domainCytoplasmic
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17157_16960270.0Topological domainLumenal
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17191_19360270.0Topological domainCytoplasmic
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17215_22460270.0Topological domainLumenal
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-1721_9860270.0Topological domainLumenal
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17246_25760270.0Topological domainCytoplasmic
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17279_27960270.0Topological domainLumenal
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17300_32060270.0Topological domainCytoplasmic
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18120_13560321.0Topological domainCytoplasmic
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18157_16960321.0Topological domainLumenal
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18191_19360321.0Topological domainCytoplasmic
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18215_22460321.0Topological domainLumenal
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-1821_9860321.0Topological domainLumenal
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18246_25760321.0Topological domainCytoplasmic
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18279_27960321.0Topological domainLumenal
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18300_32060321.0Topological domainCytoplasmic
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17120_13560270.0Topological domainCytoplasmic
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17157_16960270.0Topological domainLumenal
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17191_19360270.0Topological domainCytoplasmic
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17215_22460270.0Topological domainLumenal
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-1721_9860270.0Topological domainLumenal
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17246_25760270.0Topological domainCytoplasmic
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17279_27960270.0Topological domainLumenal
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17300_32060270.0Topological domainCytoplasmic
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18136_15660321.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18170_19060321.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18194_21460321.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18225_24560321.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18258_27860321.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-18280_29960321.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000300658-1899_11960321.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17136_15660270.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17170_19060270.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17194_21460270.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17225_24560270.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17258_27860270.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-17280_29960270.0TransmembraneHelical
HgenePGAP3chr17:37844086chr17:38556915ENST00000378011-1799_11960270.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18136_15660321.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18170_19060321.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18194_21460321.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18225_24560321.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18258_27860321.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-18280_29960321.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000300658-1899_11960321.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17136_15660270.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17170_19060270.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17194_21460270.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17225_24560270.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17258_27860270.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-17280_29960270.0TransmembraneHelical
HgenePGAP3chr17:37844087chr17:38556915ENST00000378011-1799_11960270.0TransmembraneHelical
TgeneTOP2Achr17:37844086chr17:38556915ENST000004234852035455_5728881532.0DomainToprim
TgeneTOP2Achr17:37844087chr17:38556915ENST000004234852035455_5728881532.0DomainToprim
TgeneTOP2Achr17:37844086chr17:38556915ENST000004234852035148_1508881532.0Nucleotide bindingATP
TgeneTOP2Achr17:37844086chr17:38556915ENST000004234852035161_1688881532.0Nucleotide bindingATP
TgeneTOP2Achr17:37844086chr17:38556915ENST000004234852035376_3788881532.0Nucleotide bindingATP
TgeneTOP2Achr17:37844087chr17:38556915ENST000004234852035148_1508881532.0Nucleotide bindingATP
TgeneTOP2Achr17:37844087chr17:38556915ENST000004234852035161_1688881532.0Nucleotide bindingATP
TgeneTOP2Achr17:37844087chr17:38556915ENST000004234852035376_3788881532.0Nucleotide bindingATP


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Fusion Gene Sequence for PGAP3-TOP2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64564_64564_1_PGAP3-TOP2A_PGAP3_chr17_37844086_ENST00000300658_TOP2A_chr17_38556915_ENST00000423485_length(transcript)=3209nt_BP=274nt
GTAGAATAAAGAACACAGGAACTTCCGGTTACTCCGGAAGTGGAAGCTTCATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAA
AGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTAC
CGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTA
GCAGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTCCAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAA
TTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGACATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCAC
CGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATACCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACT
GGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTAGTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGG
CTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTGAACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCT
CCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCTTTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAA
TAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATTCGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGT
TCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAAAGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTA
TCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAACTCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACAC
ATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACATTTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACA
AGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAAAAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCA
AAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGAAAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAG
CCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAAAGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACA
AACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCTGGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAA
TTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAACAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTC
AGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTAGTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAA
AGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATGTTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTAC
ACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATGTGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCAC
CTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGGATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCC
TGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATTCTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCAC
AAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACTCAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAA
ACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATGTGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAG
ACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTAGTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAA
GTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGACCATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGT
TTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTGAACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCA
GTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAAAAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATG
AGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCATCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTA
CACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCTCATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAA
AACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAATTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCC
CCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCTAAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGA
TCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATTAGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAA
CTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGTTATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTA

>64564_64564_1_PGAP3-TOP2A_PGAP3_chr17_37844086_ENST00000300658_TOP2A_chr17_38556915_ENST00000423485_length(amino acids)=630AA_BP=
MAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKL
QTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDL
ATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR
LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS
DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT
KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

--------------------------------------------------------------
>64564_64564_2_PGAP3-TOP2A_PGAP3_chr17_37844086_ENST00000378011_TOP2A_chr17_38556915_ENST00000423485_length(transcript)=3159nt_BP=224nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTC
CAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGA
CATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCACCGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATA
CCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTA
GTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGGCTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTG
AACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCT
TTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAATAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATT
CGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGTTCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAA
AGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAAC
TCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACAT
TTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACAAGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAA
AAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGA
AAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAGCCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAA
AGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCT
GGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAATTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAA
CAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTCAGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTA
GTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAAAGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATG
TTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTACACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATG
TGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCACCTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGG
ATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATT
CTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACT
CAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAAACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATG
TGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAGACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTA
GTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAAGTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGAC
CATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTG
AACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAGTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAA
AAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCA
TCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCT
CATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAA
TTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCCCCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCT
AAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATT
AGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGT
TATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTAGCTAAATTCCAACAATTTTGTACTTTAATAAAATGTTCTAAACATTGCAA

>64564_64564_2_PGAP3-TOP2A_PGAP3_chr17_37844086_ENST00000378011_TOP2A_chr17_38556915_ENST00000423485_length(amino acids)=630AA_BP=
MAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKL
QTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDL
ATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR
LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS
DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT
KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

--------------------------------------------------------------
>64564_64564_3_PGAP3-TOP2A_PGAP3_chr17_37844086_ENST00000429199_TOP2A_chr17_38556915_ENST00000423485_length(transcript)=3159nt_BP=224nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTC
CAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGA
CATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCACCGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATA
CCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTA
GTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGGCTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTG
AACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCT
TTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAATAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATT
CGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGTTCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAA
AGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAAC
TCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACAT
TTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACAAGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAA
AAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGA
AAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAGCCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAA
AGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCT
GGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAATTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAA
CAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTCAGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTA
GTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAAAGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATG
TTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTACACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATG
TGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCACCTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGG
ATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATT
CTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACT
CAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAAACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATG
TGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAGACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTA
GTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAAGTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGAC
CATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTG
AACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAGTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAA
AAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCA
TCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCT
CATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAA
TTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCCCCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCT
AAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATT
AGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGT
TATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTAGCTAAATTCCAACAATTTTGTACTTTAATAAAATGTTCTAAACATTGCAA

>64564_64564_3_PGAP3-TOP2A_PGAP3_chr17_37844086_ENST00000429199_TOP2A_chr17_38556915_ENST00000423485_length(amino acids)=630AA_BP=
MAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKL
QTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDL
ATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR
LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS
DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT
KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

--------------------------------------------------------------
>64564_64564_4_PGAP3-TOP2A_PGAP3_chr17_37844086_ENST00000579146_TOP2A_chr17_38556915_ENST00000423485_length(transcript)=3159nt_BP=224nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTC
CAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGA
CATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCACCGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATA
CCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTA
GTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGGCTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTG
AACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCT
TTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAATAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATT
CGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGTTCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAA
AGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAAC
TCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACAT
TTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACAAGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAA
AAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGA
AAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAGCCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAA
AGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCT
GGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAATTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAA
CAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTCAGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTA
GTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAAAGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATG
TTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTACACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATG
TGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCACCTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGG
ATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATT
CTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACT
CAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAAACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATG
TGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAGACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTA
GTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAAGTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGAC
CATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTG
AACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAGTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAA
AAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCA
TCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCT
CATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAA
TTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCCCCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCT
AAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATT
AGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGT
TATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTAGCTAAATTCCAACAATTTTGTACTTTAATAAAATGTTCTAAACATTGCAA

>64564_64564_4_PGAP3-TOP2A_PGAP3_chr17_37844086_ENST00000579146_TOP2A_chr17_38556915_ENST00000423485_length(amino acids)=630AA_BP=
MAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKL
QTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDL
ATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR
LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS
DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT
KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

--------------------------------------------------------------
>64564_64564_5_PGAP3-TOP2A_PGAP3_chr17_37844087_ENST00000300658_TOP2A_chr17_38556915_ENST00000423485_length(transcript)=3209nt_BP=274nt
GTAGAATAAAGAACACAGGAACTTCCGGTTACTCCGGAAGTGGAAGCTTCATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAA
AGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTAC
CGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTA
GCAGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTCCAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAA
TTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGACATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCAC
CGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATACCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACT
GGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTAGTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGG
CTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTGAACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCT
CCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCTTTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAA
TAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATTCGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGT
TCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAAAGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTA
TCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAACTCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACAC
ATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACATTTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACA
AGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAAAAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCA
AAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGAAAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAG
CCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAAAGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACA
AACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCTGGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAA
TTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAACAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTC
AGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTAGTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAA
AGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATGTTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTAC
ACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATGTGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCAC
CTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGGATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCC
TGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATTCTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCAC
AAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACTCAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAA
ACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATGTGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAG
ACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTAGTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAA
GTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGACCATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGT
TTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTGAACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCA
GTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAAAAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATG
AGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCATCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTA
CACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCTCATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAA
AACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAATTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCC
CCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCTAAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGA
TCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATTAGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAA
CTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGTTATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTA

>64564_64564_5_PGAP3-TOP2A_PGAP3_chr17_37844087_ENST00000300658_TOP2A_chr17_38556915_ENST00000423485_length(amino acids)=630AA_BP=
MAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKL
QTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDL
ATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR
LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS
DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT
KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

--------------------------------------------------------------
>64564_64564_6_PGAP3-TOP2A_PGAP3_chr17_37844087_ENST00000378011_TOP2A_chr17_38556915_ENST00000423485_length(transcript)=3159nt_BP=224nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTC
CAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGA
CATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCACCGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATA
CCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTA
GTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGGCTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTG
AACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCT
TTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAATAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATT
CGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGTTCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAA
AGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAAC
TCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACAT
TTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACAAGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAA
AAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGA
AAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAGCCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAA
AGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCT
GGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAATTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAA
CAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTCAGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTA
GTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAAAGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATG
TTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTACACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATG
TGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCACCTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGG
ATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATT
CTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACT
CAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAAACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATG
TGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAGACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTA
GTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAAGTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGAC
CATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTG
AACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAGTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAA
AAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCA
TCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCT
CATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAA
TTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCCCCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCT
AAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATT
AGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGT
TATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTAGCTAAATTCCAACAATTTTGTACTTTAATAAAATGTTCTAAACATTGCAA

>64564_64564_6_PGAP3-TOP2A_PGAP3_chr17_37844087_ENST00000378011_TOP2A_chr17_38556915_ENST00000423485_length(amino acids)=630AA_BP=
MAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKL
QTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDL
ATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR
LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS
DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT
KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

--------------------------------------------------------------
>64564_64564_7_PGAP3-TOP2A_PGAP3_chr17_37844087_ENST00000429199_TOP2A_chr17_38556915_ENST00000423485_length(transcript)=3159nt_BP=224nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTC
CAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGA
CATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCACCGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATA
CCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTA
GTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGGCTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTG
AACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCT
TTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAATAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATT
CGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGTTCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAA
AGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAAC
TCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACAT
TTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACAAGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAA
AAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGA
AAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAGCCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAA
AGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCT
GGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAATTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAA
CAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTCAGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTA
GTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAAAGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATG
TTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTACACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATG
TGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCACCTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGG
ATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATT
CTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACT
CAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAAACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATG
TGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAGACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTA
GTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAAGTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGAC
CATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTG
AACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAGTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAA
AAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCA
TCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCT
CATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAA
TTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCCCCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCT
AAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATT
AGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGT
TATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTAGCTAAATTCCAACAATTTTGTACTTTAATAAAATGTTCTAAACATTGCAA

>64564_64564_7_PGAP3-TOP2A_PGAP3_chr17_37844087_ENST00000429199_TOP2A_chr17_38556915_ENST00000423485_length(amino acids)=630AA_BP=
MAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKL
QTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDL
ATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR
LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS
DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT
KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

--------------------------------------------------------------
>64564_64564_8_PGAP3-TOP2A_PGAP3_chr17_37844087_ENST00000579146_TOP2A_chr17_38556915_ENST00000423485_length(transcript)=3159nt_BP=224nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTC
CAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGA
CATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCACCGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATA
CCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTA
GTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGGCTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTG
AACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCT
TTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAATAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATT
CGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGTTCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAA
AGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAAC
TCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACAT
TTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACAAGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAA
AAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGA
AAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAGCCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAA
AGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCT
GGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAATTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAA
CAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTCAGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTA
GTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAAAGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATG
TTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTACACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATG
TGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCACCTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGG
ATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATT
CTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACT
CAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAAACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATG
TGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAGACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTA
GTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAAGTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGAC
CATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTG
AACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAGTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAA
AAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCA
TCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCT
CATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAA
TTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCCCCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCT
AAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATT
AGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGT
TATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTAGCTAAATTCCAACAATTTTGTACTTTAATAAAATGTTCTAAACATTGCAA

>64564_64564_8_PGAP3-TOP2A_PGAP3_chr17_37844087_ENST00000579146_TOP2A_chr17_38556915_ENST00000423485_length(amino acids)=630AA_BP=
MAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKL
QTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDL
ATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR
LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS
DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT
KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGAP3-TOP2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTOP2Achr17:37844086chr17:38556915ENST000004234852035990_999888.01532.0DNA
TgeneTOP2Achr17:37844087chr17:38556915ENST000004234852035990_999888.01532.0DNA
TgeneTOP2Achr17:37844086chr17:38556915ENST0000042348520351433_1439888.01532.0PLSCR1
TgeneTOP2Achr17:37844087chr17:38556915ENST0000042348520351433_1439888.01532.0PLSCR1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGAP3-TOP2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGAP3-TOP2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource