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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PGC-PGA3 (FusionGDB2 ID:64580)

Fusion Gene Summary for PGC-PGA3

Fusion gene summary

Fusion gene information	Fusion gene name: PGC-PGA3
	Fusion gene ID: 64580
		Hgene	Tgene
	Gene symbol	PGC	PGA3
	Gene ID	5225	643834
	Gene name	progastricsin	pepsinogen A3
	Synonyms	PEPC\|PGII	-
	Cytomap	6p21.1	11q12.2
	Type of gene	protein-coding	protein-coding
	Description	gastricsinpepsin Cpepsinogen Cpepsinogen group IIpreprogastricsin	pepsin A-3pepsinogen 3, group I (pepsinogen A)pepsinogen-3
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000373025, ENST00000425343,	ENST00000325558, ENST00000538258, ENST00000543125,
Fusion gene scores	* DoF score	18 X 23 X 5=2070	21 X 19 X 7=2793
	# samples	24	23
	** MAII score	log2(24/2070*10)=-3.10852445677817 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/2793*10)=-3.60210980733558 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PGC [Title/Abstract] AND PGA3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PGA3(60974099)-PGC(41711127), # samples:18 PGC(41710027)-PGA3(60977313), # samples:13
Anticipated loss of major functional domain due to fusion event.	PGA3-PGC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PGA3-PGC seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PGC-PGA3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PGC-PGA3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PGC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PGA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	115Nd	PGC	chr6	41704448	-	PGA3	chr11	60980024	+
ChimerDB4	Non-Cancer	115Nd	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	115Nd	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
ChimerDB4	Non-Cancer	115Nd	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	115Nd	PGC	chr6	41711008	-	PGA3	chr11	60975762	+
ChimerDB4	Non-Cancer	115Nd	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	115Nd	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
ChimerDB4	Non-Cancer	117Nd	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
ChimerDB4	Non-Cancer	117Nd	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	117Nd	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	117Nd	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
ChimerDB4	Non-Cancer	119Nd	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
ChimerDB4	Non-Cancer	119Nd	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	119Nd	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	123Nd	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	123Nd	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	123Nd	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	131Nd	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	131Nd	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	137N	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
ChimerDB4	Non-Cancer	139N	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	139N	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	139N	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	139N	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
ChimerDB4	Non-Cancer	145N	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	169N	PGC	chr6	41704448	-	PGA3	chr11	60980024	+
ChimerDB4	Non-Cancer	203N	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	217N	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	267N	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	267N	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	267N	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
ChimerDB4	Non-Cancer	43N	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	5263N	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	5263N	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
ChimerDB4	Non-Cancer	5357N	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	5357N	PGC	chr6	41710027	-	PGA3	chr11	60980024	+
ChimerDB4	Non-Cancer	5357N	PGC	chr6	41712134	-	PGA3	chr11	60970983	+
ChimerDB4	Non-Cancer	5357N	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	5357N	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
ChimerDB4	Non-Cancer	5381N	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	5381N	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
ChimerDB4	Non-Cancer	5759N	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
ChimerDB4	Non-Cancer	5759N	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	TCGA-BR-6458-11A	PGC	chr6	41705480	-	PGA3	chr11	60970997	+
ChimerDB4	Non-Cancer	TCGA-BR-6458-11A	PGC	chr6	41705488	-	PGA3	chr11	60970989	+
ChimerDB4	Non-Cancer	TCGA-BR-6458-11A	PGC	chr6	41705523	-	PGA3	chr11	60970989	+
ChimerDB4	Non-Cancer	TCGA-BR-6458-11A	PGC	chr6	41711072	-	PGA3	chr11	60970987	+
ChimerDB4	Non-Cancer	TCGA-BR-7715-11A	PGC	chr6	41705488	-	PGA3	chr11	60970989	+
ChimerDB4	Non-Cancer	TCGA-L5-A4OG-11A	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
ChimerDB4	Non-Cancer	TCGA-L5-A4OJ-11A	PGC	chr6	41705467	-	PGA3	chr11	60980024	+

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Fusion Gene ORF analysis for PGC-PGA3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000373025	ENST00000325558	PGC	chr6	41712134	-	PGA3	chr11	60970983	+
5CDS-5UTR	ENST00000425343	ENST00000325558	PGC	chr6	41712134	-	PGA3	chr11	60970983	+
5CDS-intron	ENST00000373025	ENST00000538258	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
5CDS-intron	ENST00000373025	ENST00000538258	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
5CDS-intron	ENST00000373025	ENST00000538258	PGC	chr6	41711008	-	PGA3	chr11	60975762	+
5CDS-intron	ENST00000373025	ENST00000538258	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
5CDS-intron	ENST00000373025	ENST00000538258	PGC	chr6	41712134	-	PGA3	chr11	60970983	+
5CDS-intron	ENST00000373025	ENST00000538258	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
5CDS-intron	ENST00000373025	ENST00000543125	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
5CDS-intron	ENST00000373025	ENST00000543125	PGC	chr6	41711008	-	PGA3	chr11	60975762	+
5CDS-intron	ENST00000373025	ENST00000543125	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
5CDS-intron	ENST00000373025	ENST00000543125	PGC	chr6	41712134	-	PGA3	chr11	60970983	+
5CDS-intron	ENST00000373025	ENST00000543125	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
5CDS-intron	ENST00000425343	ENST00000538258	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
5CDS-intron	ENST00000425343	ENST00000538258	PGC	chr6	41711008	-	PGA3	chr11	60975762	+
5CDS-intron	ENST00000425343	ENST00000538258	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
5CDS-intron	ENST00000425343	ENST00000538258	PGC	chr6	41712134	-	PGA3	chr11	60970983	+
5CDS-intron	ENST00000425343	ENST00000538258	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
5CDS-intron	ENST00000425343	ENST00000543125	PGC	chr6	41711008	-	PGA3	chr11	60975762	+
5CDS-intron	ENST00000425343	ENST00000543125	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
5CDS-intron	ENST00000425343	ENST00000543125	PGC	chr6	41712134	-	PGA3	chr11	60970983	+
5CDS-intron	ENST00000425343	ENST00000543125	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
Frame-shift	ENST00000373025	ENST00000325558	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
Frame-shift	ENST00000373025	ENST00000325558	PGC	chr6	41710027	-	PGA3	chr11	60980024	+
Frame-shift	ENST00000373025	ENST00000538258	PGC	chr6	41704448	-	PGA3	chr11	60980024	+
Frame-shift	ENST00000373025	ENST00000538258	PGC	chr6	41710027	-	PGA3	chr11	60980024	+
Frame-shift	ENST00000373025	ENST00000538258	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
Frame-shift	ENST00000373025	ENST00000543125	PGC	chr6	41704448	-	PGA3	chr11	60980024	+
Frame-shift	ENST00000373025	ENST00000543125	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
Frame-shift	ENST00000425343	ENST00000325558	PGC	chr6	41710027	-	PGA3	chr11	60980024	+
Frame-shift	ENST00000425343	ENST00000538258	PGC	chr6	41710027	-	PGA3	chr11	60980024	+
In-frame	ENST00000373025	ENST00000325558	PGC	chr6	41704448	-	PGA3	chr11	60980024	+
In-frame	ENST00000373025	ENST00000325558	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
In-frame	ENST00000373025	ENST00000325558	PGC	chr6	41711008	-	PGA3	chr11	60975762	+
In-frame	ENST00000373025	ENST00000325558	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
In-frame	ENST00000373025	ENST00000325558	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
In-frame	ENST00000373025	ENST00000325558	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
In-frame	ENST00000373025	ENST00000543125	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
In-frame	ENST00000373025	ENST00000543125	PGC	chr6	41710027	-	PGA3	chr11	60980024	+
In-frame	ENST00000425343	ENST00000325558	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
In-frame	ENST00000425343	ENST00000325558	PGC	chr6	41711008	-	PGA3	chr11	60975762	+
In-frame	ENST00000425343	ENST00000325558	PGC	chr6	41712395	-	PGA3	chr11	60973981	+
In-frame	ENST00000425343	ENST00000325558	PGC	chr6	41712134	-	PGA3	chr11	60974968	+
In-frame	ENST00000425343	ENST00000543125	PGC	chr6	41710027	-	PGA3	chr11	60977313	+
In-frame	ENST00000425343	ENST00000543125	PGC	chr6	41710027	-	PGA3	chr11	60980024	+
intron-3CDS	ENST00000425343	ENST00000325558	PGC	chr6	41704448	-	PGA3	chr11	60980024	+
intron-3CDS	ENST00000425343	ENST00000325558	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
intron-3CDS	ENST00000425343	ENST00000325558	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
intron-3CDS	ENST00000425343	ENST00000538258	PGC	chr6	41704448	-	PGA3	chr11	60980024	+
intron-3CDS	ENST00000425343	ENST00000538258	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
intron-3CDS	ENST00000425343	ENST00000543125	PGC	chr6	41704448	-	PGA3	chr11	60980024	+
intron-3CDS	ENST00000425343	ENST00000543125	PGC	chr6	41705467	-	PGA3	chr11	60980024	+
intron-5UTR	ENST00000373025	ENST00000325558	PGC	chr6	41705480	-	PGA3	chr11	60970997	+
intron-5UTR	ENST00000373025	ENST00000325558	PGC	chr6	41705523	-	PGA3	chr11	60970989	+
intron-5UTR	ENST00000373025	ENST00000325558	PGC	chr6	41711072	-	PGA3	chr11	60970987	+
intron-5UTR	ENST00000373025	ENST00000325558	PGC	chr6	41705488	-	PGA3	chr11	60970989	+
intron-5UTR	ENST00000425343	ENST00000325558	PGC	chr6	41705480	-	PGA3	chr11	60970997	+
intron-5UTR	ENST00000425343	ENST00000325558	PGC	chr6	41705523	-	PGA3	chr11	60970989	+
intron-5UTR	ENST00000425343	ENST00000325558	PGC	chr6	41711072	-	PGA3	chr11	60970987	+
intron-5UTR	ENST00000425343	ENST00000325558	PGC	chr6	41705488	-	PGA3	chr11	60970989	+
intron-intron	ENST00000373025	ENST00000538258	PGC	chr6	41705480	-	PGA3	chr11	60970997	+
intron-intron	ENST00000373025	ENST00000538258	PGC	chr6	41705523	-	PGA3	chr11	60970989	+
intron-intron	ENST00000373025	ENST00000538258	PGC	chr6	41711072	-	PGA3	chr11	60970987	+
intron-intron	ENST00000373025	ENST00000538258	PGC	chr6	41705488	-	PGA3	chr11	60970989	+
intron-intron	ENST00000373025	ENST00000543125	PGC	chr6	41705480	-	PGA3	chr11	60970997	+
intron-intron	ENST00000373025	ENST00000543125	PGC	chr6	41705523	-	PGA3	chr11	60970989	+
intron-intron	ENST00000373025	ENST00000543125	PGC	chr6	41711072	-	PGA3	chr11	60970987	+
intron-intron	ENST00000373025	ENST00000543125	PGC	chr6	41705488	-	PGA3	chr11	60970989	+
intron-intron	ENST00000425343	ENST00000538258	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
intron-intron	ENST00000425343	ENST00000538258	PGC	chr6	41705480	-	PGA3	chr11	60970997	+
intron-intron	ENST00000425343	ENST00000538258	PGC	chr6	41705523	-	PGA3	chr11	60970989	+
intron-intron	ENST00000425343	ENST00000538258	PGC	chr6	41711072	-	PGA3	chr11	60970987	+
intron-intron	ENST00000425343	ENST00000538258	PGC	chr6	41705488	-	PGA3	chr11	60970989	+
intron-intron	ENST00000425343	ENST00000543125	PGC	chr6	41705467	-	PGA3	chr11	60974968	+
intron-intron	ENST00000425343	ENST00000543125	PGC	chr6	41705480	-	PGA3	chr11	60970997	+
intron-intron	ENST00000425343	ENST00000543125	PGC	chr6	41705523	-	PGA3	chr11	60970989	+
intron-intron	ENST00000425343	ENST00000543125	PGC	chr6	41711072	-	PGA3	chr11	60970987	+
intron-intron	ENST00000425343	ENST00000543125	PGC	chr6	41705488	-	PGA3	chr11	60970989	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000373025	PGC	chr6	41705467	-	ENST00000325558	PGA3	chr11	60980024	+	1623	1077	6	1226	406
ENST00000373025	PGC	chr6	41712134	-	ENST00000325558	PGA3	chr11	60974968	+	1617	391	6	1220	404
ENST00000425343	PGC	chr6	41712134	-	ENST00000325558	PGA3	chr11	60974968	+	1621	395	10	1224	404
ENST00000373025	PGC	chr6	41704448	-	ENST00000325558	PGA3	chr11	60980024	+	1917	1371	6	1229	407
ENST00000373025	PGC	chr6	41710027	-	ENST00000325558	PGA3	chr11	60977313	+	1617	710	6	1220	404
ENST00000373025	PGC	chr6	41710027	-	ENST00000543125	PGA3	chr11	60977313	+	1384	710	6	1220	404
ENST00000425343	PGC	chr6	41710027	-	ENST00000325558	PGA3	chr11	60977313	+	1621	714	10	1224	404
ENST00000425343	PGC	chr6	41710027	-	ENST00000543125	PGA3	chr11	60977313	+	1388	714	10	1224	404
ENST00000373025	PGC	chr6	41711008	-	ENST00000325558	PGA3	chr11	60975762	+	1617	510	6	1220	404
ENST00000425343	PGC	chr6	41711008	-	ENST00000325558	PGA3	chr11	60975762	+	1621	514	10	1224	404
ENST00000373025	PGC	chr6	41712395	-	ENST00000325558	PGA3	chr11	60973981	+	1617	273	6	1220	404
ENST00000425343	PGC	chr6	41712395	-	ENST00000325558	PGA3	chr11	60973981	+	1621	277	10	1224	404
ENST00000373025	PGC	chr6	41710027	-	ENST00000543125	PGA3	chr11	60980024	+	1023	710	6	746	246
ENST00000425343	PGC	chr6	41710027	-	ENST00000543125	PGA3	chr11	60980024	+	1027	714	10	750	246

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373025	ENST00000325558	PGC	chr6	41705467	-	PGA3	chr11	60980024	+	0.002177491	0.9978225
ENST00000373025	ENST00000325558	PGC	chr6	41712134	-	PGA3	chr11	60974968	+	0.002184846	0.99781513
ENST00000425343	ENST00000325558	PGC	chr6	41712134	-	PGA3	chr11	60974968	+	0.002225621	0.9977743
ENST00000373025	ENST00000325558	PGC	chr6	41704448	-	PGA3	chr11	60980024	+	0.002624859	0.99737513
ENST00000373025	ENST00000325558	PGC	chr6	41710027	-	PGA3	chr11	60977313	+	0.002200292	0.9977997
ENST00000373025	ENST00000543125	PGC	chr6	41710027	-	PGA3	chr11	60977313	+	0.002898321	0.9971016
ENST00000425343	ENST00000325558	PGC	chr6	41710027	-	PGA3	chr11	60977313	+	0.002220952	0.9977791
ENST00000425343	ENST00000543125	PGC	chr6	41710027	-	PGA3	chr11	60977313	+	0.002915157	0.9970848
ENST00000373025	ENST00000325558	PGC	chr6	41711008	-	PGA3	chr11	60975762	+	0.001852187	0.99814785
ENST00000425343	ENST00000325558	PGC	chr6	41711008	-	PGA3	chr11	60975762	+	0.001894381	0.99810565
ENST00000373025	ENST00000325558	PGC	chr6	41712395	-	PGA3	chr11	60973981	+	0.001927635	0.9980724
ENST00000425343	ENST00000325558	PGC	chr6	41712395	-	PGA3	chr11	60973981	+	0.001985776	0.9980142
ENST00000373025	ENST00000543125	PGC	chr6	41710027	-	PGA3	chr11	60980024	+	0.004201887	0.99579805
ENST00000425343	ENST00000543125	PGC	chr6	41710027	-	PGA3	chr11	60980024	+	0.004559017	0.99544096

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Fusion Genomic Features for PGC-PGA3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PGC	chr6	41711008	-	PGA3	chr11	60975762	+	0.14029615	0.8597039
PGC	chr6	41704448	-	PGA3	chr11	60980024	+	0.09827042	0.9017296
PGC	chr6	41705467	-	PGA3	chr11	60980024	+	0.08651711	0.91348284
PGC	chr6	41710027	-	PGA3	chr11	60980024	+	0.003074122	0.9969259
PGC	chr6	41712395	-	PGA3	chr11	60973981	+	9.77E-05	0.99990225
PGC	chr6	41712134	-	PGA3	chr11	60974968	+	6.75E-06	0.9999932
PGC	chr6	41710027	-	PGA3	chr11	60977313	+	4.98E-06	0.999995
PGC	chr6	41705467	-	PGA3	chr11	60974968	+	3.83E-06	0.9999962
PGC	chr6	41711008	-	PGA3	chr11	60975762	+	0.14029615	0.8597039
PGC	chr6	41704448	-	PGA3	chr11	60980024	+	0.09827042	0.9017296
PGC	chr6	41705467	-	PGA3	chr11	60980024	+	0.08651711	0.91348284
PGC	chr6	41710027	-	PGA3	chr11	60980024	+	0.003074122	0.9969259
PGC	chr6	41712395	-	PGA3	chr11	60973981	+	9.77E-05	0.99990225
PGC	chr6	41712134	-	PGA3	chr11	60974968	+	6.75E-06	0.9999932
PGC	chr6	41710027	-	PGA3	chr11	60977313	+	4.98E-06	0.999995
PGC	chr6	41705467	-	PGA3	chr11	60974968	+	3.83E-06	0.9999962

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGC-PGA3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:60974099/chr11:41711127)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGC

chr6:41704448

chr11:60980024

ENST00000373025

73_385

436

389.0

Domain

Peptidase A1

Tgene

PGA3

chr6:41712395

chr11:60973981

ENST00000325558

76_385

389.0

Domain

Peptidase A1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGC

chr6:41704448

chr11:60980024

ENST00000425343

73_385

316.0

Domain

Peptidase A1

Hgene

PGC

chr6:41705467

chr11:60980024

ENST00000373025

73_385

338

389.0

Domain

Peptidase A1

Hgene

PGC

chr6:41705467

chr11:60980024

ENST00000425343

73_385

316.0

Domain

Peptidase A1

Hgene

PGC

chr6:41710027

chr11:60977313

ENST00000373025

73_385

215

389.0

Domain

Peptidase A1

Hgene

PGC

chr6:41710027

chr11:60977313

ENST00000425343

73_385

215

316.0

Domain

Peptidase A1

Hgene

PGC

chr6:41710027

chr11:60980024

ENST00000373025

73_385

215

389.0

Domain

Peptidase A1

Hgene

PGC

chr6:41710027

chr11:60980024

ENST00000425343

73_385

215

316.0

Domain

Peptidase A1

Hgene

PGC

chr6:41711008

chr11:60975762

ENST00000373025

73_385

149

389.0

Domain

Peptidase A1

Hgene

PGC

chr6:41711008

chr11:60975762

ENST00000425343

73_385

149

316.0

Domain

Peptidase A1

Hgene

PGC

chr6:41712134

chr11:60974968

ENST00000373025

73_385

109

389.0

Domain

Peptidase A1

Hgene

PGC

chr6:41712134

chr11:60974968

ENST00000425343

73_385

109

316.0

Domain

Peptidase A1

Hgene

PGC

chr6:41712395

chr11:60973981

ENST00000373025

73_385

389.0

Domain

Peptidase A1

Hgene

PGC

chr6:41712395

chr11:60973981

ENST00000425343

73_385

316.0

Domain

Peptidase A1

Tgene

PGA3

chr6:41704448

chr11:60980024

ENST00000325558

76_385

339

389.0

Domain

Peptidase A1

Tgene

PGA3

chr6:41705467

chr11:60980024

ENST00000325558

76_385

339

389.0

Domain

Peptidase A1

Tgene

PGA3

chr6:41710027

chr11:60977313

ENST00000325558

76_385

218

389.0

Domain

Peptidase A1

Tgene

PGA3

chr6:41710027

chr11:60980024

ENST00000325558

76_385

339

389.0

Domain

Peptidase A1

Tgene

PGA3

chr6:41711008

chr11:60975762

ENST00000325558

76_385

152

389.0

Domain

Peptidase A1

Tgene

PGA3

chr6:41712134

chr11:60974968

ENST00000325558

76_385

112

389.0

Domain

Peptidase A1

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Fusion Gene Sequence for PGC-PGA3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64580_64580_1_PGC-PGA3_PGC_chr6_41704448_ENST00000373025_PGA3_chr11_60980024_ENST00000325558_length(transcript)=1917nt_BP=1371nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAG
TTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTG
GATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACCAGCAGGGC
TCCAGCGGGGGAGCGGTTGTCTTTGGGGGTGTGGATAGCAGCCTGTACACGGGGCAGATCTACTGGGCGCCTGTCACCCAGGAACTCTAC
TGGCAGATTGGCATTGAAGAGTTCCTCATCGGCGGCCAGGCCTCCGGCTGGTGTTCTGAGGGTTGCCAGGCCATCGTGGACACAGGCACC
TCTCTGCTCACTGTGCCCCAGCAGTACATGAGTGCTCTTCTGCAGGCCACAGGGGCCCAGGAGGATGAGTATGGACAGTTTCTCGTGAAC
TGTAACAGCATTCAGAATCTGCCCAGCTTGACCTTCATCATCAATGGTGTGGAGTTCCCTCTGCCACCTTCCTCCTATATCCTCAGTAAC
AACGGCTACTGCACCGTGGGAGTCGAGCCCACCTACCTGTCCTCCCAGAACGGCCAGCCCCTGTGGATCCTCGGGGATGTCTTCCTCAGG
TCCTACTATTCCGTCTACGACTTGGGCAACAACAGAGTAGGCTTTGCCACTGCCGCCTAGACTTGCTGCCTCGACACGTGGGCTCCCCTC
TTCCTCTTGACCCTGCACCCTCCTAGGGCATTGTATCTGTCTTTCCACTCTGGATTCAGCCTTCTTTTTCTGGACTCTGGACTTTCTCTA
ATAATAAATAGTTCTTCTTTAAGCGAGGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATC
CTGGGTGATGTCTTCATCCGCCAGTACTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTC
TCTTCAGCCACCTCCCAGGAAGATCTGGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTG
TGGAGGTCTTGGCCCTGTTCCCTGTCCTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTT
GCTGGTCTTTTTCCTTCACATTACTGGGGTTAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTG
ACCCCAGCAGCTGACACTTCATGATGGAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTC

>64580_64580_1_PGC-PGA3_PGC_chr6_41704448_ENST00000373025_PGA3_chr11_60980024_ENST00000325558_length(amino acids)=407AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQ
IGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNG

--------------------------------------------------------------
>64580_64580_2_PGC-PGA3_PGC_chr6_41705467_ENST00000373025_PGA3_chr11_60980024_ENST00000325558_length(transcript)=1623nt_BP=1077nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAG
TTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTG
GATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACCAGCAGGGC
TCCAGCGGGGGAGCGGTTGTCTTTGGGGGTGTGGATAGCAGCCTGTACACGGGGCAGATCTACTGGGCGCCTGTCACCCAGGAACTCTAC
TGGCAGATTGGCATTGAAGAGTTCCTCATCGGCGGCCAGGCCTCCGGCTGGTGTTCTGAGGGTTGCCAGGCCATCGTGGACACAGGCACC
TCTCTGCTCACTGTGCCCCAGCAGTACATGAGTGCTCTTCTGCAGGCCACAGGGGCCCAGGAGGATGAGTATGGACAGTTTCTCGTGAAC
TGTAACAGCATTCAGAATCTGCCCAGCTTGACCTTCATCATCAATGGTGTGGAGTTCCCTCTGCCACCTTCCTCCTATATCCTCAGTAGC
GAGGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAG
TACTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGAT
CTGGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTG
TCCTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTAC
TGGGGTTAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGA
TGGAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTCAAAATACTGGGCTAATTGTCTTCT

>64580_64580_2_PGC-PGA3_PGC_chr6_41705467_ENST00000373025_PGA3_chr11_60980024_ENST00000325558_length(amino acids)=406AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQ
IGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSSEG

--------------------------------------------------------------
>64580_64580_3_PGC-PGA3_PGC_chr6_41710027_ENST00000373025_PGA3_chr11_60977313_ENST00000325558_length(transcript)=1617nt_BP=710nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAG
TTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTG
GATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACGATGACCAG
AGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGG
CAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTG
CTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCA
GCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGG
AGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTT
ACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCC
TCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCCTAC
CAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTGGGGT
TAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATGGAGC

>64580_64580_3_PGC-PGA3_PGC_chr6_41710027_ENST00000373025_PGA3_chr11_60977313_ENST00000325558_length(amino acids)=404AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNDDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_4_PGC-PGA3_PGC_chr6_41710027_ENST00000373025_PGA3_chr11_60977313_ENST00000543125_length(transcript)=1384nt_BP=710nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAG
TTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTG
GATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACGATGACCAG
AGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGG
CAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTG
CTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCA
GCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGG
AGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTT
ACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCC
TCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCCTAC

>64580_64580_4_PGC-PGA3_PGC_chr6_41710027_ENST00000373025_PGA3_chr11_60977313_ENST00000543125_length(amino acids)=404AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNDDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_5_PGC-PGA3_PGC_chr6_41710027_ENST00000373025_PGA3_chr11_60980024_ENST00000543125_length(transcript)=1023nt_BP=710nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAG
TTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTG
GATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAAAGCGAGGGGA
GCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTTA
CCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCCT
CTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCCTACC

>64580_64580_5_PGC-PGA3_PGC_chr6_41710027_ENST00000373025_PGA3_chr11_60980024_ENST00000543125_length(amino acids)=246AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG

--------------------------------------------------------------
>64580_64580_6_PGC-PGA3_PGC_chr6_41710027_ENST00000425343_PGA3_chr11_60977313_ENST00000325558_length(transcript)=1621nt_BP=714nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTG
GGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCA
GACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCA
GGAGTTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTC
CGTGGATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACGATGA
CCAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTA
CTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTC
TCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTG
CTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGA
GGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTA
CTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCT
GGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTC
CTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTG
GGGTTAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATG
GAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTCAAAATACTGGGCTAATTGTCTTCTCA

>64580_64580_6_PGC-PGA3_PGC_chr6_41710027_ENST00000425343_PGA3_chr11_60977313_ENST00000325558_length(amino acids)=404AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNDDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_7_PGC-PGA3_PGC_chr6_41710027_ENST00000425343_PGA3_chr11_60977313_ENST00000543125_length(transcript)=1388nt_BP=714nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTG
GGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCA
GACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCA
GGAGTTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTC
CGTGGATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACGATGA
CCAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTA
CTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTC
TCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTG
CTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGA
GGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTA
CTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCT
GGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTC

>64580_64580_7_PGC-PGA3_PGC_chr6_41710027_ENST00000425343_PGA3_chr11_60977313_ENST00000543125_length(amino acids)=404AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG
LSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNDDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_8_PGC-PGA3_PGC_chr6_41710027_ENST00000425343_PGA3_chr11_60980024_ENST00000543125_length(transcript)=1027nt_BP=714nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTG
GGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCA
GACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCA
GGAGTTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTC
CGTGGATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAAAGCGAG
GGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTAC
TTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTG
GCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCC

>64580_64580_8_PGC-PGA3_PGC_chr6_41710027_ENST00000425343_PGA3_chr11_60980024_ENST00000543125_length(amino acids)=246AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFG

--------------------------------------------------------------
>64580_64580_9_PGC-PGA3_PGC_chr6_41711008_ENST00000373025_PGA3_chr11_60975762_ENST00000325558_length(transcript)=1617nt_BP=510nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTTGGAGGCATCTCTGACACCAATCAGATC
TTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCC
TCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACCAG
AGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGG
CAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTG
CTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCA
GCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGG
AGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTT
ACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCC
TCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCCTAC
CAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTGGGGT
TAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATGGAGC

>64580_64580_9_PGC-PGA3_PGC_chr6_41711008_ENST00000373025_PGA3_chr11_60975762_ENST00000325558_length(amino acids)=404AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_10_PGC-PGA3_PGC_chr6_41711008_ENST00000425343_PGA3_chr11_60975762_ENST00000325558_length(transcript)=1621nt_BP=514nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTG
GGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCA
GACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTTGGAGGCATCTCTGACACCAATCA
GATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTC
CTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGA
CCAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTA
CTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTC
TCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTG
CTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGA
GGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTA
CTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCT
GGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTC
CTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTG
GGGTTAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATG
GAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTCAAAATACTGGGCTAATTGTCTTCTCA

>64580_64580_10_PGC-PGA3_PGC_chr6_41711008_ENST00000425343_PGA3_chr11_60975762_ENST00000325558_length(amino acids)=404AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_11_PGC-PGA3_PGC_chr6_41712134_ENST00000373025_PGA3_chr11_60974968_ENST00000325558_length(transcript)=1617nt_BP=391nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAACCACAACCGCTTCAACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGAGACA
GTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCAGATC
TTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCC
TCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACCAG
AGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGG
CAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTG
CTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCA
GCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGG
AGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTT
ACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCC
TCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCCTAC
CAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTGGGGT
TAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATGGAGC

>64580_64580_11_PGC-PGA3_PGC_chr6_41712134_ENST00000373025_PGA3_chr11_60974968_ENST00000325558_length(amino acids)=404AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_12_PGC-PGA3_PGC_chr6_41712134_ENST00000425343_PGA3_chr11_60974968_ENST00000325558_length(transcript)=1621nt_BP=395nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTG
GGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAACCACAACCGCTTCAACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGA
GACAGTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCA
GATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTC
CTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGA
CCAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTA
CTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTC
TCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTG
CTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGA
GGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTA
CTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCT
GGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTC
CTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTG
GGGTTAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATG
GAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTCAAAATACTGGGCTAATTGTCTTCTCA

>64580_64580_12_PGC-PGA3_PGC_chr6_41712134_ENST00000425343_PGA3_chr11_60974968_ENST00000325558_length(amino acids)=404AA_BP=91
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDA
AYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_13_PGC-PGA3_PGC_chr6_41712395_ENST00000373025_PGA3_chr11_60973981_ENST00000325558_length(transcript)=1617nt_BP=273nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATATGGAGTACTTCGGCACTATCGGCATCGGAACTCCTGCCCAGGATTTCACCGTCGTCTTTGACACCGGCTCCTCCAACCTGTGGGTG
CCCTCAGTCTACTGCTCCAGTCTTGCCTGCACCAACCACAACCGCTTCAACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGAGACA
GTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCAGATC
TTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCC
TCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGACCAG
AGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGG
CAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTCTCTG
CTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCA
GCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGAGGGG
AGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTT
ACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCTGGCC
TCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTCCTAC
CAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTGGGGT
TAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATGGAGC

>64580_64580_13_PGC-PGA3_PGC_chr6_41712395_ENST00000373025_PGA3_chr11_60973981_ENST00000325558_length(amino acids)=404AA_BP=89
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDM
EYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------
>64580_64580_14_PGC-PGA3_PGC_chr6_41712395_ENST00000425343_PGA3_chr11_60973981_ENST00000325558_length(transcript)=1621nt_BP=277nt
CTTCACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTT
GGTCTGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTT
GCTGGGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTA
CATGGATATGGAGTACTTCGGCACTATCGGCATCGGAACTCCTGCCCAGGATTTCACCGTCGTCTTTGACACCGGCTCCTCCAACCTGTG
GGTGCCCTCAGTCTACTGCTCCAGTCTTGCCTGCACCAACCACAACCGCTTCAACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGA
GACAGTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCA
GATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTC
CTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGATGA
CCAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGTCTGAACTGGGTGCCTGTTACCGTCGAGGGTTA
CTGGCAGATCACCGTGGACAGCATCACCATGAACGGAGAGGCCATCGCCTGCGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACCTC
TCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGCGAGAACTCAGATGGCGACATGGTGGTCAGCTG
CTCAGCCATCAGCAGCCTGCCCGACATCGTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGCGA
GGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACCTCCCCACCGAATCTGGAGAGCTTTGGATCCTGGGTGATGTCTTCATCCGCCAGTA
CTTTACCGTCTTCGACAGGGCAAACAACCAGGTCGGCCTGGCCCCCGTGGCTTAAGCCTAAGTCTCTTCAGCCACCTCCCAGGAAGATCT
GGCCTCTGTCCTGTGCCCACTTTAGATGTATCTAATTCTCCTGACTGTTCTTCCCAGGGGAGTGTGGAGGTCTTGGCCCTGTTCCCTGTC
CTACCAATAACGTAGAATAAAAACATAACCCACTGAAACAGGTTTTGTGGAGCTGCTTCTCTTTGCTGGTCTTTTTCCTTCACATTACTG
GGGTTAGAACACCAGGGCAGGGATGAAAATGACCACATCCATTTGGATGGCACCCAACATAGTGACCCCAGCAGCTGACACTTCATGATG
GAGCCAAGAAGACAGAGAGGCTTCGGGGGTTGTGCTGGAAGCATCATAAAAAGACCTGGGGGTCAAAATACTGGGCTAATTGTCTTCTCA

>64580_64580_14_PGC-PGA3_PGC_chr6_41712395_ENST00000425343_PGA3_chr11_60973981_ENST00000325558_length(amino acids)=404AA_BP=89
MRLQNSELLFLCGQLGTSIMKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDM
EYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFG
LSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI
TVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSC

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PGC-PGA3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PGC-PGA3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PGC-PGA3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source