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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGK1-TP53BP1 (FusionGDB2 ID:64613)

Fusion Gene Summary for PGK1-TP53BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PGK1-TP53BP1
Fusion gene ID: 64613
HgeneTgene
Gene symbol

PGK1

TP53BP1

Gene ID

5230

7158

Gene namephosphoglycerate kinase 1tumor protein p53 binding protein 1
SynonymsHEL-S-68p|MIG10|PGKA53BP1|TDRD30|p202|p53BP1
Cytomap

Xq21.1

15q15.3

Type of geneprotein-codingprotein-coding
Descriptionphosphoglycerate kinase 1PRP 2cell migration-inducing gene 10 proteinepididymis secretory sperm binding protein Li 68pprimer recognition protein 2TP53-binding protein 1p53-binding protein 1tumor protein 53-binding protein, 1tumor suppressor p53-binding protein 1
Modification date2020031320200322
UniProtAcc.

Q12888

Ensembl transtripts involved in fusion geneENST00000476531, ENST00000373316, 
ENST00000442431, ENST00000537456, 
ENST00000263801, ENST00000382039, 
ENST00000382044, ENST00000450115, 
ENST00000605155, 
Fusion gene scores* DoF score5 X 5 X 3=756 X 6 X 3=108
# samples 66
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGK1 [Title/Abstract] AND TP53BP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGK1(77380895)-TP53BP1(43705524), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePGK1

GO:0071456

cellular response to hypoxia

11130727

TgeneTP53BP1

GO:0006303

double-strand break repair via nonhomologous end joining

23333306|23760478|28241136

TgeneTP53BP1

GO:0006974

cellular response to DNA damage stimulus

17500065|28241136

TgeneTP53BP1

GO:0045830

positive regulation of isotype switching

23345425

TgeneTP53BP1

GO:0051260

protein homooligomerization

23345425

TgeneTP53BP1

GO:2000042

negative regulation of double-strand break repair via homologous recombination

23333306|23345425


check buttonFusion gene breakpoints across PGK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TP53BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABQ349520PGK1chrX

77380895

+TP53BP1chr15

43705524

-


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Fusion Gene ORF analysis for PGK1-TP53BP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000476531ENST00000263801PGK1chrX

77380895

+TP53BP1chr15

43705524

-
3UTR-3CDSENST00000476531ENST00000382039PGK1chrX

77380895

+TP53BP1chr15

43705524

-
3UTR-3CDSENST00000476531ENST00000382044PGK1chrX

77380895

+TP53BP1chr15

43705524

-
3UTR-3CDSENST00000476531ENST00000450115PGK1chrX

77380895

+TP53BP1chr15

43705524

-
3UTR-intronENST00000476531ENST00000605155PGK1chrX

77380895

+TP53BP1chr15

43705524

-
5CDS-intronENST00000373316ENST00000605155PGK1chrX

77380895

+TP53BP1chr15

43705524

-
5CDS-intronENST00000442431ENST00000605155PGK1chrX

77380895

+TP53BP1chr15

43705524

-
5CDS-intronENST00000537456ENST00000605155PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000373316ENST00000263801PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000373316ENST00000382039PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000373316ENST00000382044PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000373316ENST00000450115PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000442431ENST00000263801PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000442431ENST00000382039PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000442431ENST00000382044PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000442431ENST00000450115PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000537456ENST00000263801PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000537456ENST00000382039PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000537456ENST00000382044PGK1chrX

77380895

+TP53BP1chr15

43705524

-
In-frameENST00000537456ENST00000450115PGK1chrX

77380895

+TP53BP1chr15

43705524

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373316PGK1chrX77380895+ENST00000263801TP53BP1chr1543705524-231913081251495456
ENST00000373316PGK1chrX77380895+ENST00000382039TP53BP1chr1543705524-231413081251495456
ENST00000373316PGK1chrX77380895+ENST00000382044TP53BP1chr1543705524-231413081251495456
ENST00000373316PGK1chrX77380895+ENST00000450115TP53BP1chr1543705524-231413081252146673
ENST00000442431PGK1chrX77380895+ENST00000263801TP53BP1chr1543705524-1830819441006320
ENST00000442431PGK1chrX77380895+ENST00000382039TP53BP1chr1543705524-18258199661322
ENST00000442431PGK1chrX77380895+ENST00000382044TP53BP1chr1543705524-18258199661322
ENST00000442431PGK1chrX77380895+ENST00000450115TP53BP1chr1543705524-1825819441657537
ENST00000537456PGK1chrX77380895+ENST00000263801TP53BP1chr1543705524-239713862091573454
ENST00000537456PGK1chrX77380895+ENST00000382039TP53BP1chr1543705524-239213862091573454
ENST00000537456PGK1chrX77380895+ENST00000382044TP53BP1chr1543705524-239213862091573454
ENST00000537456PGK1chrX77380895+ENST00000450115TP53BP1chr1543705524-239213862092224671

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373316ENST00000263801PGK1chrX77380895+TP53BP1chr1543705524-0.001087880.9989121
ENST00000373316ENST00000382039PGK1chrX77380895+TP53BP1chr1543705524-0.0011241230.9988759
ENST00000373316ENST00000382044PGK1chrX77380895+TP53BP1chr1543705524-0.0011241230.9988759
ENST00000373316ENST00000450115PGK1chrX77380895+TP53BP1chr1543705524-0.0011682330.9988318
ENST00000442431ENST00000263801PGK1chrX77380895+TP53BP1chr1543705524-0.00183270.9981673
ENST00000442431ENST00000382039PGK1chrX77380895+TP53BP1chr1543705524-0.0018646720.9981353
ENST00000442431ENST00000382044PGK1chrX77380895+TP53BP1chr1543705524-0.0018646720.9981353
ENST00000442431ENST00000450115PGK1chrX77380895+TP53BP1chr1543705524-0.0015706890.99842924
ENST00000537456ENST00000263801PGK1chrX77380895+TP53BP1chr1543705524-0.0022658990.99773407
ENST00000537456ENST00000382039PGK1chrX77380895+TP53BP1chr1543705524-0.0023554670.9976445
ENST00000537456ENST00000382044PGK1chrX77380895+TP53BP1chr1543705524-0.0023554670.9976445
ENST00000537456ENST00000450115PGK1chrX77380895+TP53BP1chr1543705524-0.0027923790.9972076

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Fusion Genomic Features for PGK1-TP53BP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGK1-TP53BP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:77380895/chr15:43705524)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TP53BP1

Q12888

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:27153538, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306, PubMed:27153538). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:27153538, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTP53BP1chrX:77380895chr15:43705524ENST000002638010281642_164601973.0Compositional biasNote=Poly-Ser
TgeneTP53BP1chrX:77380895chr15:43705524ENST000002638010281760_176401973.0Compositional biasNote=Poly-Glu
TgeneTP53BP1chrX:77380895chr15:43705524ENST000003820440281642_164601978.0Compositional biasNote=Poly-Ser
TgeneTP53BP1chrX:77380895chr15:43705524ENST000003820440281760_176401978.0Compositional biasNote=Poly-Glu
TgeneTP53BP1chrX:77380895chr15:43705524ENST000002638010281724_184801973.0DomainBRCT 1
TgeneTP53BP1chrX:77380895chr15:43705524ENST000002638010281864_196401973.0DomainBRCT 2
TgeneTP53BP1chrX:77380895chr15:43705524ENST000003820440281724_184801978.0DomainBRCT 1
TgeneTP53BP1chrX:77380895chr15:43705524ENST000003820440281864_196401978.0DomainBRCT 2
TgeneTP53BP1chrX:77380895chr15:43705524ENST000002638010281396_140301973.0MotifGAR
TgeneTP53BP1chrX:77380895chr15:43705524ENST000002638010281604_163101973.0MotifUDR
TgeneTP53BP1chrX:77380895chr15:43705524ENST000003820440281396_140301978.0MotifGAR
TgeneTP53BP1chrX:77380895chr15:43705524ENST000003820440281604_163101978.0MotifUDR
TgeneTP53BP1chrX:77380895chr15:43705524ENST000002638010281484_160301973.0RegionTudor-like
TgeneTP53BP1chrX:77380895chr15:43705524ENST000003820440281484_160301978.0RegionTudor-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGK1chrX:77380895chr15:43705524ENST00000373316+111373_3760418.0Nucleotide bindingATP
HgenePGK1chrX:77380895chr15:43705524ENST00000373316+11124_260418.0RegionSubstrate binding
HgenePGK1chrX:77380895chr15:43705524ENST00000373316+11163_660418.0RegionSubstrate binding


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Fusion Gene Sequence for PGK1-TP53BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64613_64613_1_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000373316_TP53BP1_chr15_43705524_ENST00000263801_length(transcript)=2319nt_BP=1308nt
CAGCGGCCGGGAAGGGGCGGTGCGGGAGGCGGGGTGTGGGGCGGTAGTGTGGGCCCTGTTCCTGCCCGCGCGGTGTTCCGCATTCTGCAA
GCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGTCGCTTTCTA
ACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAA
CAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAG
GCCGGCCTGATGGTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGT
TCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTC
ATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTT
CCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGG
CTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAG
CTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCC
TTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGA
AGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTT
CTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTG
TGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTA
GGGGCTGCATCACCATCATAGGTGGTGCCAGTTTGGAGCTCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCT
CATGCCCAGCCTCGGTGCTGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGG
AGAGAATTGGATTCAAGCAGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTA
TCGTGGAGATTGTGTTTTAACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTG
AACTTTTATGATAAAATAAATGTTGAATCTCTTTGGTTGTAGTAACTGGGGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTC
TTGGTATCAGACCAACAGCAGAACTTCCTGGAGCTCTGGTCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCA
AGTGCCCATAACAAAGTGTAACACAGCTTACCAGTGTCTTCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGC
CAGTGGGATTCCTTGTGTGTCTCATGTCTGGGTCCATGATAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGC
TGGGTACAGCCTTGAGGAGCAAAGAATTCTGGACTGAATTTTTGGAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAG
CAGGAGCTGGCTATATCCTTGAAGATTTCAATGAAGCCCAGGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTG
AACCCTCTGCCCTGGAAGAGCAGAGAGGGCCTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAA

>64613_64613_1_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000373316_TP53BP1_chr15_43705524_ENST00000263801_length(amino acids)=456AA_BP=
MTESPTSLPSCISKMSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKY
SLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAF
GTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTS
LFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWE
AFARGTKALMDEVVKATSRGCITIIGGASLELLEDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYK

--------------------------------------------------------------
>64613_64613_2_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000373316_TP53BP1_chr15_43705524_ENST00000382039_length(transcript)=2314nt_BP=1308nt
CAGCGGCCGGGAAGGGGCGGTGCGGGAGGCGGGGTGTGGGGCGGTAGTGTGGGCCCTGTTCCTGCCCGCGCGGTGTTCCGCATTCTGCAA
GCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGTCGCTTTCTA
ACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAA
CAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAG
GCCGGCCTGATGGTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGT
TCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTC
ATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTT
CCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGG
CTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAG
CTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCC
TTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGA
AGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTT
CTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTG
TGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTA
GGGGCTGCATCACCATCATAGGTGGTGCCAGTTTGGAGCTCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCT
CATGCCCAGCCTCGGTGCTGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGG
AGAGAATTGGATTCAAGCAGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTA
TCGTGGAGATTGTGTTTTAACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTG
AACTTTTATGATAAAATAAATGTTGAATCTCTTTGGTTGTAGTAAGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGT
ATCAGACCAACAGCAGAACTTCCTGGAGCTCTGGTCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGC
CCATAACAAAGTGTAACACAGCTTACCAGTGTCTTCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTG
GGATTCCTTGTGTGTCTCATGTCTGGGTCCATGATAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGT
ACAGCCTTGAGGAGCAAAGAATTCTGGACTGAATTTTTGGAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGA
GCTGGCTATATCCTTGAAGATTTCAATGAAGCCCAGGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCC
TCTGCCCTGGAAGAGCAGAGAGGGCCTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGT

>64613_64613_2_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000373316_TP53BP1_chr15_43705524_ENST00000382039_length(amino acids)=456AA_BP=
MTESPTSLPSCISKMSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKY
SLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAF
GTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTS
LFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWE
AFARGTKALMDEVVKATSRGCITIIGGASLELLEDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYK

--------------------------------------------------------------
>64613_64613_3_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000373316_TP53BP1_chr15_43705524_ENST00000382044_length(transcript)=2314nt_BP=1308nt
CAGCGGCCGGGAAGGGGCGGTGCGGGAGGCGGGGTGTGGGGCGGTAGTGTGGGCCCTGTTCCTGCCCGCGCGGTGTTCCGCATTCTGCAA
GCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGTCGCTTTCTA
ACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAA
CAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAG
GCCGGCCTGATGGTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGT
TCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTC
ATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTT
CCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGG
CTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAG
CTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCC
TTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGA
AGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTT
CTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTG
TGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTA
GGGGCTGCATCACCATCATAGGTGGTGCCAGTTTGGAGCTCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCT
CATGCCCAGCCTCGGTGCTGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGG
AGAGAATTGGATTCAAGCAGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTA
TCGTGGAGATTGTGTTTTAACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTG
AACTTTTATGATAAAATAAATGTTGAATCTCTTTGGTTGTAGTAAGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGT
ATCAGACCAACAGCAGAACTTCCTGGAGCTCTGGTCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGC
CCATAACAAAGTGTAACACAGCTTACCAGTGTCTTCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTG
GGATTCCTTGTGTGTCTCATGTCTGGGTCCATGATAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGT
ACAGCCTTGAGGAGCAAAGAATTCTGGACTGAATTTTTGGAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGA
GCTGGCTATATCCTTGAAGATTTCAATGAAGCCCAGGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCC
TCTGCCCTGGAAGAGCAGAGAGGGCCTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGT

>64613_64613_3_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000373316_TP53BP1_chr15_43705524_ENST00000382044_length(amino acids)=456AA_BP=
MTESPTSLPSCISKMSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKY
SLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAF
GTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTS
LFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWE
AFARGTKALMDEVVKATSRGCITIIGGASLELLEDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYK

--------------------------------------------------------------
>64613_64613_4_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000373316_TP53BP1_chr15_43705524_ENST00000450115_length(transcript)=2314nt_BP=1308nt
CAGCGGCCGGGAAGGGGCGGTGCGGGAGGCGGGGTGTGGGGCGGTAGTGTGGGCCCTGTTCCTGCCCGCGCGGTGTTCCGCATTCTGCAA
GCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGTCGCTTTCTA
ACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAA
CAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAG
GCCGGCCTGATGGTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGT
TCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTC
ATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTT
CCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGG
CTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAG
CTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCC
TTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGA
AGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTT
CTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTG
TGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTA
GGGGCTGCATCACCATCATAGGTGGTGCCAGTTTGGAGCTCCTGGAAGTAGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACA
ACACCGGTGAACCCTCTGCCCTGGAAGAGCAGAGAGGGCCTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCA
TGGCCACAACCAGTGACAAGTTGGCCAGCCGCTCCAAACTGCCAGATGGTCCTACAGGAAGCAGTGAAGAAGAGGAGGAATTTTTGGAAA
TTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGAGCTGGCTATATCCTTGAAGATTTCAATGAAGCCCAGTGTAACA
CAGCTTACCAGTGTCTTCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCCTTGTGTGTCTC
ATGTCTGGGTCCATGATAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCTTGAGGAGCAAA
GAATTCTGGACTGGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGTATCAGACCAACAGCAGAACTTCCTGGAGCTCT
GGTCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGCCCATAACAAAGATATTGCTTTAGGGGTATTTG
ATGTGGTGGTGACGGACCCCTCATGCCCAGCCTCGGTGCTGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGA
TCCAGTGCCTCATTGTTGGGGAGAGAATTGGATTCAAGCAGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCT
TACTGGTTTTATTCCCTGCTATCGTGGAGATTGTGTTTTAACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCT

>64613_64613_4_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000373316_TP53BP1_chr15_43705524_ENST00000450115_length(amino acids)=673AA_BP=394
MTESPTSLPSCISKMSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKY
SLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAF
GTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTS
LFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWE
AFARGTKALMDEVVKATSRGCITIIGGASLELLEVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFLLTMATTSDKLASRS
KLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQ
LQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPAS

--------------------------------------------------------------
>64613_64613_5_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000442431_TP53BP1_chr15_43705524_ENST00000263801_length(transcript)=1830nt_BP=819nt
ATTCTGCAAGCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGT
CGCTTTCTAACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACA
ACCAGATAACAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGA
GCCACCTAGGCCGGCCTGATGGTCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGC
TGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGT
TTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCA
CTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTC
CTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTT
TTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCACCATCATAGGTGGTGCCAGTTTGGAGC
TCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCTCATGCCCAGCCTCGGTGCTGAAGTGTGCTGAAGCATTGC
AGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGGAGAGAATTGGATTCAAGCAGCATCCAAAATATAAACACG
ATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTATCGTGGAGATTGTGTTTTAACCAGGTTTTAAATGTGTCT
TGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTGAACTTTTATGATAAAATAAATGTTGAATCTCTTTGGTTG
TAGTAACTGGGGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGTATCAGACCAACAGCAGAACTTCCTGGAGCTCTGG
TCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGCCCATAACAAAGTGTAACACAGCTTACCAGTGTCT
TCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCCTTGTGTGTCTCATGTCTGGGTCCATGA
TAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCTTGAGGAGCAAAGAATTCTGGACTGAAT
TTTTGGAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGAGCTGGCTATATCCTTGAAGATTTCAATGAAGCCC
AGGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCCTCTGCCCTGGAAGAGCAGAGAGGGCCTTTGCCTC
TCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGTGACAAGTTGGCCAGCCGCTCCAAACTGCCAGATG

>64613_64613_5_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000442431_TP53BP1_chr15_43705524_ENST00000263801_length(amino acids)=320AA_BP=
MTESPTSLPSCISKMSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGRPFLAIL
GGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQAT
VASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGASLELLEDIALGVFDVVVT

--------------------------------------------------------------
>64613_64613_6_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000442431_TP53BP1_chr15_43705524_ENST00000382039_length(transcript)=1825nt_BP=819nt
ATTCTGCAAGCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGT
CGCTTTCTAACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACA
ACCAGATAACAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGA
GCCACCTAGGCCGGCCTGATGGTCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGC
TGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGT
TTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCA
CTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTC
CTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTT
TTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCACCATCATAGGTGGTGCCAGTTTGGAGC
TCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCTCATGCCCAGCCTCGGTGCTGAAGTGTGCTGAAGCATTGC
AGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGGAGAGAATTGGATTCAAGCAGCATCCAAAATATAAACACG
ATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTATCGTGGAGATTGTGTTTTAACCAGGTTTTAAATGTGTCT
TGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTGAACTTTTATGATAAAATAAATGTTGAATCTCTTTGGTTG
TAGTAAGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGTATCAGACCAACAGCAGAACTTCCTGGAGCTCTGGTCTGA
GATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGCCCATAACAAAGTGTAACACAGCTTACCAGTGTCTTCTAA
TTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCCTTGTGTGTCTCATGTCTGGGTCCATGATAGTT
GCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCTTGAGGAGCAAAGAATTCTGGACTGAATTTTTG
GAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGAGCTGGCTATATCCTTGAAGATTTCAATGAAGCCCAGGGG
GCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCCTCTGCCCTGGAAGAGCAGAGAGGGCCTTTGCCTCTCAAC
AAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGTGACAAGTTGGCCAGCCGCTCCAAACTGCCAGATGGTCCT

>64613_64613_6_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000442431_TP53BP1_chr15_43705524_ENST00000382039_length(amino acids)=322AA_BP=
MNPILSPTMRHWITHSCDTTGSCNASAHFSTEAGHEGSVTTTSNTPKAISSRSSKLAPPMMVMQPLEVAFTTSSMRALVPRAKASHSNTP
TGPFHTICLARVTASAYFLLLSGPQSKPIQPAGMPEATVAWPVLAFSSNLSAVTKSTGKVIFTPFFSALDIRSLTILAPSSSNREVPISM
LLSTLRKVKAIPPPIIISLTLSSILLMSWILSATLAPPRMARKGRPSGRPRWLIRTTDLAPLSKQNLMLGTAALILWLFVIWLFFIGTLK

--------------------------------------------------------------
>64613_64613_7_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000442431_TP53BP1_chr15_43705524_ENST00000382044_length(transcript)=1825nt_BP=819nt
ATTCTGCAAGCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGT
CGCTTTCTAACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACA
ACCAGATAACAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGA
GCCACCTAGGCCGGCCTGATGGTCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGC
TGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGT
TTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCA
CTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTC
CTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTT
TTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCACCATCATAGGTGGTGCCAGTTTGGAGC
TCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCTCATGCCCAGCCTCGGTGCTGAAGTGTGCTGAAGCATTGC
AGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGGAGAGAATTGGATTCAAGCAGCATCCAAAATATAAACACG
ATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTATCGTGGAGATTGTGTTTTAACCAGGTTTTAAATGTGTCT
TGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTGAACTTTTATGATAAAATAAATGTTGAATCTCTTTGGTTG
TAGTAAGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGTATCAGACCAACAGCAGAACTTCCTGGAGCTCTGGTCTGA
GATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGCCCATAACAAAGTGTAACACAGCTTACCAGTGTCTTCTAA
TTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCCTTGTGTGTCTCATGTCTGGGTCCATGATAGTT
GCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCTTGAGGAGCAAAGAATTCTGGACTGAATTTTTG
GAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGAGCTGGCTATATCCTTGAAGATTTCAATGAAGCCCAGGGG
GCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCCTCTGCCCTGGAAGAGCAGAGAGGGCCTTTGCCTCTCAAC
AAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGTGACAAGTTGGCCAGCCGCTCCAAACTGCCAGATGGTCCT

>64613_64613_7_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000442431_TP53BP1_chr15_43705524_ENST00000382044_length(amino acids)=322AA_BP=
MNPILSPTMRHWITHSCDTTGSCNASAHFSTEAGHEGSVTTTSNTPKAISSRSSKLAPPMMVMQPLEVAFTTSSMRALVPRAKASHSNTP
TGPFHTICLARVTASAYFLLLSGPQSKPIQPAGMPEATVAWPVLAFSSNLSAVTKSTGKVIFTPFFSALDIRSLTILAPSSSNREVPISM
LLSTLRKVKAIPPPIIISLTLSSILLMSWILSATLAPPRMARKGRPSGRPRWLIRTTDLAPLSKQNLMLGTAALILWLFVIWLFFIGTLK

--------------------------------------------------------------
>64613_64613_8_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000442431_TP53BP1_chr15_43705524_ENST00000450115_length(transcript)=1825nt_BP=819nt
ATTCTGCAAGCCTCCGGAGCGCACGTCGGCAGTCGGCTCCCTCGTTGACCGAATCACCGACCTCTCTCCCCAGCTGTATTTCCAAAATGT
CGCTTTCTAACAAGCTGACGCTGGACAAGCTGGACGTTAAAGGGAAGCGGGTCGTTATGAGAGTCGACTTCAATGTTCCTATGAAGAACA
ACCAGATAACAAACAACCAGAGGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGA
GCCACCTAGGCCGGCCTGATGGTCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGC
TGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGT
TTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCA
CTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTC
CTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTT
TTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCACCATCATAGGTGGTGCCAGTTTGGAGC
TCCTGGAAGTAGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCCTCTGCCCTGGAAGAGCAGAGAGGGC
CTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGTGACAAGTTGGCCAGCCGCTCCAAAC
TGCCAGATGGTCCTACAGGAAGCAGTGAAGAAGAGGAGGAATTTTTGGAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTC
GAGCAGGAGCTGGCTATATCCTTGAAGATTTCAATGAAGCCCAGTGTAACACAGCTTACCAGTGTCTTCTAATTGCGGATCAGCATTGTC
GAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCCTTGTGTGTCTCATGTCTGGGTCCATGATAGTTGCCATGCCAACCAGCTCC
AGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCTTGAGGAGCAAAGAATTCTGGACTGGCAACCCCGTGAAAATCCTTTCCAGA
ATCTGAAGGTACTCTTGGTATCAGACCAACAGCAGAACTTCCTGGAGCTCTGGTCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGA
AGCAGCACCATTCAAGTGCCCATAACAAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCTCATGCCCAGCCTCGGTGC
TGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGGAGAGAATTGGATTCAAGC
AGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTATCGTGGAGATTGTGTTTT
AACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTGAACTTTTATGATAAAATA

>64613_64613_8_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000442431_TP53BP1_chr15_43705524_ENST00000450115_length(amino acids)=537AA_BP=258
MTESPTSLPSCISKMSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGRPFLAIL
GGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQAT
VASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGASLELLEVGAGEFVSPCES
GDNTGEPSALEEQRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQ
CNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFL

--------------------------------------------------------------
>64613_64613_9_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000537456_TP53BP1_chr15_43705524_ENST00000263801_length(transcript)=2397nt_BP=1386nt
AACCTGGATACCTTCTACTTATTTAGGCTGAGGACAGGAAGTTACATGGTTCCCTGATTATTAATGTATTTCTTTTGAACAGAGAGTCAC
ATTGTAGGCCTACTTTTTTGGAGGTGCTTAGGCAGCCATGTGGTGTCAGCTCAATTCCTTTTTGTTTCAACGTGGTGGTTGCTGGCGGTG
TTTCCGGAATGGGGCTTCCTGAGTAGTGGCTGCCTCATTTGTCGTCTTTGTCCTGCAGAAGTGAACTATGGTATTTGCTGACTCTTCTGG
TCCACTGGTTTGGATTGCCAAGGGAAATTGATTTGTTGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAACAACCAGA
GGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAGGCCGGCCTGATG
GTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGTTCTTGAAGGACT
GTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTCATGTGGAGGAAG
AAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTTCCAAGCTAGGGG
ATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGGCTGGTGGGTTTT
TGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAG
ACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCA
ACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGA
AGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTG
CTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTC
CTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCA
CCATCATAGGTGGTGCCAGTTTGGAGCTCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCTCATGCCCAGCCT
CGGTGCTGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGGAGAGAATTGGAT
TCAAGCAGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTATCGTGGAGATTG
TGTTTTAACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTGAACTTTTATGAT
AAAATAAATGTTGAATCTCTTTGGTTGTAGTAACTGGGGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGTATCAGAC
CAACAGCAGAACTTCCTGGAGCTCTGGTCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGCCCATAAC
AAAGTGTAACACAGCTTACCAGTGTCTTCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCC
TTGTGTGTCTCATGTCTGGGTCCATGATAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCT
TGAGGAGCAAAGAATTCTGGACTGAATTTTTGGAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGAGCTGGCT
ATATCCTTGAAGATTTCAATGAAGCCCAGGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCCTCTGCCC
TGGAAGAGCAGAGAGGGCCTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGTGACAAGT

>64613_64613_9_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000537456_TP53BP1_chr15_43705524_ENST00000263801_length(amino acids)=454AA_BP=
MPHLSSLSCRSELWYLLTLLVHWFGLPREIDLLRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSL
EPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGT
AHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLF
DEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAF
ARGTKALMDEVVKATSRGCITIIGGASLELLEDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHD

--------------------------------------------------------------
>64613_64613_10_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000537456_TP53BP1_chr15_43705524_ENST00000382039_length(transcript)=2392nt_BP=1386nt
AACCTGGATACCTTCTACTTATTTAGGCTGAGGACAGGAAGTTACATGGTTCCCTGATTATTAATGTATTTCTTTTGAACAGAGAGTCAC
ATTGTAGGCCTACTTTTTTGGAGGTGCTTAGGCAGCCATGTGGTGTCAGCTCAATTCCTTTTTGTTTCAACGTGGTGGTTGCTGGCGGTG
TTTCCGGAATGGGGCTTCCTGAGTAGTGGCTGCCTCATTTGTCGTCTTTGTCCTGCAGAAGTGAACTATGGTATTTGCTGACTCTTCTGG
TCCACTGGTTTGGATTGCCAAGGGAAATTGATTTGTTGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAACAACCAGA
GGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAGGCCGGCCTGATG
GTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGTTCTTGAAGGACT
GTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTCATGTGGAGGAAG
AAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTTCCAAGCTAGGGG
ATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGGCTGGTGGGTTTT
TGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAG
ACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCA
ACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGA
AGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTG
CTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTC
CTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCA
CCATCATAGGTGGTGCCAGTTTGGAGCTCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCTCATGCCCAGCCT
CGGTGCTGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGGAGAGAATTGGAT
TCAAGCAGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTATCGTGGAGATTG
TGTTTTAACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTGAACTTTTATGAT
AAAATAAATGTTGAATCTCTTTGGTTGTAGTAAGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGTATCAGACCAACA
GCAGAACTTCCTGGAGCTCTGGTCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGCCCATAACAAAGT
GTAACACAGCTTACCAGTGTCTTCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCCTTGTG
TGTCTCATGTCTGGGTCCATGATAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCTTGAGG
AGCAAAGAATTCTGGACTGAATTTTTGGAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGAGCTGGCTATATC
CTTGAAGATTTCAATGAAGCCCAGGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCCTCTGCCCTGGAA
GAGCAGAGAGGGCCTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGTGACAAGTTGGCC

>64613_64613_10_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000537456_TP53BP1_chr15_43705524_ENST00000382039_length(amino acids)=454AA_BP=
MPHLSSLSCRSELWYLLTLLVHWFGLPREIDLLRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSL
EPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGT
AHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLF
DEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAF
ARGTKALMDEVVKATSRGCITIIGGASLELLEDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHD

--------------------------------------------------------------
>64613_64613_11_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000537456_TP53BP1_chr15_43705524_ENST00000382044_length(transcript)=2392nt_BP=1386nt
AACCTGGATACCTTCTACTTATTTAGGCTGAGGACAGGAAGTTACATGGTTCCCTGATTATTAATGTATTTCTTTTGAACAGAGAGTCAC
ATTGTAGGCCTACTTTTTTGGAGGTGCTTAGGCAGCCATGTGGTGTCAGCTCAATTCCTTTTTGTTTCAACGTGGTGGTTGCTGGCGGTG
TTTCCGGAATGGGGCTTCCTGAGTAGTGGCTGCCTCATTTGTCGTCTTTGTCCTGCAGAAGTGAACTATGGTATTTGCTGACTCTTCTGG
TCCACTGGTTTGGATTGCCAAGGGAAATTGATTTGTTGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAACAACCAGA
GGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAGGCCGGCCTGATG
GTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGTTCTTGAAGGACT
GTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTCATGTGGAGGAAG
AAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTTCCAAGCTAGGGG
ATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGGCTGGTGGGTTTT
TGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAG
ACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCA
ACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGA
AGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTG
CTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTC
CTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCA
CCATCATAGGTGGTGCCAGTTTGGAGCTCCTGGAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGACGGACCCCTCATGCCCAGCCT
CGGTGCTGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCATTGTTGGGGAGAGAATTGGAT
TCAAGCAGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTATTCCCTGCTATCGTGGAGATTG
TGTTTTAACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTTTATTTGCTGAACTTTTATGAT
AAAATAAATGTTGAATCTCTTTGGTTGTAGTAAGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGTATCAGACCAACA
GCAGAACTTCCTGGAGCTCTGGTCTGAGATCCTCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGCCCATAACAAAGT
GTAACACAGCTTACCAGTGTCTTCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCCTTGTG
TGTCTCATGTCTGGGTCCATGATAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCTTGAGG
AGCAAAGAATTCTGGACTGAATTTTTGGAAATTCCTCCTTTCAACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGAGCTGGCTATATC
CTTGAAGATTTCAATGAAGCCCAGGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAACCCTCTGCCCTGGAA
GAGCAGAGAGGGCCTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCAGTGACAAGTTGGCC

>64613_64613_11_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000537456_TP53BP1_chr15_43705524_ENST00000382044_length(amino acids)=454AA_BP=
MPHLSSLSCRSELWYLLTLLVHWFGLPREIDLLRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSL
EPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGT
AHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLF
DEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAF
ARGTKALMDEVVKATSRGCITIIGGASLELLEDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHD

--------------------------------------------------------------
>64613_64613_12_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000537456_TP53BP1_chr15_43705524_ENST00000450115_length(transcript)=2392nt_BP=1386nt
AACCTGGATACCTTCTACTTATTTAGGCTGAGGACAGGAAGTTACATGGTTCCCTGATTATTAATGTATTTCTTTTGAACAGAGAGTCAC
ATTGTAGGCCTACTTTTTTGGAGGTGCTTAGGCAGCCATGTGGTGTCAGCTCAATTCCTTTTTGTTTCAACGTGGTGGTTGCTGGCGGTG
TTTCCGGAATGGGGCTTCCTGAGTAGTGGCTGCCTCATTTGTCGTCTTTGTCCTGCAGAAGTGAACTATGGTATTTGCTGACTCTTCTGG
TCCACTGGTTTGGATTGCCAAGGGAAATTGATTTGTTGAGAGTCGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAACAACCAGA
GGATTAAGGCTGCTGTCCCAAGCATCAAATTCTGCTTGGACAATGGAGCCAAGTCGGTAGTCCTTATGAGCCACCTAGGCCGGCCTGATG
GTGTGCCCATGCCTGACAAGTACTCCTTAGAGCCAGTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTCTGTTCTTGAAGGACT
GTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCCGCTTTCATGTGGAGGAAG
AAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTTCACTTTCCAAGCTAGGGG
ATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCACAGAAGGCTGGTGGGTTTT
TGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAG
ACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTACCTTCCTTAAGGTGCTCA
ACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAGCTGAGAAGAATGGTGTGA
AGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTG
CTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGCAGATTGTGTGGAATGGTC
CTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATCA
CCATCATAGGTGGTGCCAGTTTGGAGCTCCTGGAAGTAGGGGCAGGAGAGTTTGTGAGCCCCTGTGAGAGTGGAGACAACACCGGTGAAC
CCTCTGCCCTGGAAGAGCAGAGAGGGCCTTTGCCTCTCAACAAGACCTTGTTTCTGGGCTACGCATTTCTCCTTACCATGGCCACAACCA
GTGACAAGTTGGCCAGCCGCTCCAAACTGCCAGATGGTCCTACAGGAAGCAGTGAAGAAGAGGAGGAATTTTTGGAAATTCCTCCTTTCA
ACAAGCAGTATACAGAATCCCAGCTTCGAGCAGGAGCTGGCTATATCCTTGAAGATTTCAATGAAGCCCAGTGTAACACAGCTTACCAGT
GTCTTCTAATTGCGGATCAGCATTGTCGAACCCGGAAGTACTTCCTGTGCCTTGCCAGTGGGATTCCTTGTGTGTCTCATGTCTGGGTCC
ATGATAGTTGCCATGCCAACCAGCTCCAGAACTACCGTAATTATCTGTTGCCAGCTGGGTACAGCCTTGAGGAGCAAAGAATTCTGGACT
GGCAACCCCGTGAAAATCCTTTCCAGAATCTGAAGGTACTCTTGGTATCAGACCAACAGCAGAACTTCCTGGAGCTCTGGTCTGAGATCC
TCATGACTGGTGGTGCAGCCTCTGTGAAGCAGCACCATTCAAGTGCCCATAACAAAGATATTGCTTTAGGGGTATTTGATGTGGTGGTGA
CGGACCCCTCATGCCCAGCCTCGGTGCTGAAGTGTGCTGAAGCATTGCAGCTGCCTGTGGTGTCACAAGAGTGGGTGATCCAGTGCCTCA
TTGTTGGGGAGAGAATTGGATTCAAGCAGCATCCAAAATATAAACACGATTATGTTTCTCACTAAAGATACTTGGTCTTACTGGTTTTAT
TCCCTGCTATCGTGGAGATTGTGTTTTAACCAGGTTTTAAATGTGTCTTGTGTGTAACTGGATTCCTTGCATGGATCTTGTATATAGTTT

>64613_64613_12_PGK1-TP53BP1_PGK1_chrX_77380895_ENST00000537456_TP53BP1_chr15_43705524_ENST00000450115_length(amino acids)=671AA_BP=392
MPHLSSLSCRSELWYLLTLLVHWFGLPREIDLLRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSL
EPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGT
AHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLF
DEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAF
ARGTKALMDEVVKATSRGCITIIGGASLELLEVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKL
PDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQ
NYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPASVL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGK1-TP53BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTP53BP1chrX:77380895chr15:43705524ENST000002638010281495_152301973.0dimethylated histone H4
TgeneTP53BP1chrX:77380895chr15:43705524ENST000003820440281495_152301978.0dimethylated histone H4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGK1-TP53BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGK1-TP53BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource