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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGPEP1-C10orf76 (FusionGDB2 ID:64647)

Fusion Gene Summary for PGPEP1-C10orf76

check button Fusion gene summary
Fusion gene informationFusion gene name: PGPEP1-C10orf76
Fusion gene ID: 64647
HgeneTgene
Gene symbol

PGPEP1

C10orf76

Gene ID

54858

79591

Gene namepyroglutamyl-peptidase Iarmadillo like helical domain containing 3
SynonymsPAP-I|PGI|PGP|PGP-I|PGPI|PcpC10orf76
Cytomap

19p13.11

10q24.32

Type of geneprotein-codingprotein-coding
Descriptionpyroglutamyl-peptidase 15-oxoprolyl-peptidasepGlu-peptidase Ipyroglutamyl aminopeptidase Ipyrrolidone-carboxylate peptidasearmadillo-like helical domain-containing protein 3UPF0668 protein C10orf76
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269919, ENST00000595066, 
ENST00000597431, ENST00000604499, 
ENST00000252813, 		ENST00000311122, 
ENST00000495001, ENST00000370033, 
Fusion gene scores* DoF score7 X 5 X 6=2108 X 6 X 5=240
# samples 89
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGPEP1 [Title/Abstract] AND C10orf76 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGPEP1(18453721)-C10orf76(103773781), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PGPEP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C10orf76 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-A3-3323-01APGPEP1chr19

18453721

+C10orf76chr10

103773781

-


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Fusion Gene ORF analysis for PGPEP1-C10orf76

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000269919ENST00000311122PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
5CDS-intronENST00000269919ENST00000495001PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
5CDS-intronENST00000595066ENST00000311122PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
5CDS-intronENST00000595066ENST00000495001PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
5CDS-intronENST00000597431ENST00000311122PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
5CDS-intronENST00000597431ENST00000495001PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
5CDS-intronENST00000604499ENST00000311122PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
5CDS-intronENST00000604499ENST00000495001PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
In-frameENST00000269919ENST00000370033PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
In-frameENST00000595066ENST00000370033PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
In-frameENST00000597431ENST00000370033PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
In-frameENST00000604499ENST00000370033PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
intron-3CDSENST00000252813ENST00000370033PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
intron-intronENST00000252813ENST00000311122PGPEP1chr19

18453721

+C10orf76chr10

103773781

-
intron-intronENST00000252813ENST00000495001PGPEP1chr19

18453721

+C10orf76chr10

103773781

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000269919PGPEP1chr1918453721+ENST00000370033C10orf76chr10103773781-3512182951582495
ENST00000604499PGPEP1chr1918453721+ENST00000370033C10orf76chr10103773781-3501171841571495
ENST00000595066PGPEP1chr1918453721+ENST00000370033C10orf76chr10103773781-3500170831570495
ENST00000597431PGPEP1chr1918453721+ENST00000370033C10orf76chr10103773781-3460130431530495

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000269919ENST00000370033PGPEP1chr1918453721+C10orf76chr10103773781-0.0033988650.9966011
ENST00000604499ENST00000370033PGPEP1chr1918453721+C10orf76chr10103773781-0.0034472150.9965528
ENST00000595066ENST00000370033PGPEP1chr1918453721+C10orf76chr10103773781-0.0034343240.99656576
ENST00000597431ENST00000370033PGPEP1chr1918453721+C10orf76chr10103773781-0.0031166290.99688333

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Fusion Genomic Features for PGPEP1-C10orf76


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGPEP1-C10orf76


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:18453721/chr10:103773781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneC10orf76chr19:18453721chr10:103773781ENST00000370033726520_538223690.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PGPEP1-C10orf76


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64647_64647_1_PGPEP1-C10orf76_PGPEP1_chr19_18453721_ENST00000269919_C10orf76_chr10_103773781_ENST00000370033_length(transcript)=3512nt_BP=182nt
AGGGGCGTGGCCTCGCGCGGCCGAGAGGCTGCAGCGGCAGCAGCTGTCGCGCCAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCGATC
CCGCCATGGAGCAGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTTTGGGGAACACACCGTGAACGCCAGTTGGATTGCAGTTC
AGTCTGTGAATCCTTATATTGTGAAGCTGTCTATCGTGGATGATGAGGCCACACTCAATGGAATGGGACTTGTAATTGCTCAGGCTTTAT
CTGAGTACAACAGGCAGTATAAAGACAAGGAAGAAGAACACCAAAGTGGTTTTTTCTCTGCTTTAACAAATATGGTGGGCAGCATGTTCA
TAGCAGATGCCCATGAGAAAATCTCAGTACAAACCAATGAGGCCATTCTTCTGGCACTTTATGAAGCTGTTCATTTAAATCGCAACTTCA
TCACAGTATTAGCTCAGAGCCATCCAGAAATGGGCTTGGTGACGACCCCTGTCAGTCCTGCTCCTACAACCCCAGTCACACCACTTGGGA
CCACACCGCCTTCCTCTGATGTTATAAGTTCTGTGGAACTCCCACTGGATGCAGATGTACAGACCAGTAATCTACTGATAACCTTTTTAA
AGTATAGCTCAATTGTCATGCAGGACACCAAAGATGAACACAGGCTTCACAGTGGCAAACTCTGTCTGATTATCCTTACATGTATTGCAG
AGGATCAATATGCCAATGCATTTTTGCATGATGACAACATGAATTTTCGAGTAAACTTACATAGAATGCCTATGAGACACAGGAAGAAGG
CAGCAGACAAGAATCTTCCCTGCCGTCCTTTAGTATGTGCAGTACTGGACCTGATGGTAGAGTTTATTGTAACACACATGATGAAGGAGT
TTCCTATGGATCTCTATATACGCTGCATCCAGGTAGTACACAAACTGCTCTGCTACCAGAAGAAGTGTCGGGTACGCCTGCATTACACCT
GGCGGGAGCTCTGGTCAGCCTTGATAAATTTGCTGAAGTTCCTTATGTCAAATGAGACTGTACTTTTGGCCAAACACAACATTTTTACAT
TAGCCCTTATGATTGTGAACCTATTTAATATGTTTATCACATATGGCGACACATTTCTGCCAACCCCCAGCAGCTATGATGAACTTTACT
ATGAGATTATCCGCATGCACCAGAGCTTTGACAACCTCTACTCCATGGTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAG
CTAGCAAGGTGACCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACA
TATCCCAACTGTCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGT
ATGAGCGCTACTCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCT
TCCACACACTCAGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTAC
CCATGAGGATCATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTG
AAGACCGCACTTCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTG
GGGAGAGGCCTCCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCT
ACTGACTAATTTTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAG
ATCAACTCTCAGATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACT
GGCACTTTGTCCAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGT
CTCACTCTGTCGCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTC
AGCCTCCCGAGTAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTAC
CCAGGATGGTCTCAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGC
CAGTTTTCCTATTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCC
TTTTGAATTTTAGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCT
TAACTTTTAATTTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACT
TTGCTGGTTCCCTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACG
TGTTCCACCCCCTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGC
CTGGGAGGGAGAGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGC
TCAGATTCTGGGTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACT
ATAGGCTTTCCCAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGG
AGCAAACAGCACTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAAC
CTCAAATCTCTTTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCAC
TAACAGGCTGCCATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTT
AGTGTTTTCCCTGGTGATAAATCCCCAAGGCAGCTGGATTTGGAGCTGGTGGCAAGTTGAAATTATTAAAAATTGATTTGTGTGGGACTG

>64647_64647_1_PGPEP1-C10orf76_PGPEP1_chr19_18453721_ENST00000269919_C10orf76_chr10_103773781_ENST00000370033_length(amino acids)=495AA_BP=28
MEQPRKAVVVTGFGPFGEHTVNASWIAVQSVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIA
DAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKY
SSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFP
MDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYE
IIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYE

--------------------------------------------------------------
>64647_64647_2_PGPEP1-C10orf76_PGPEP1_chr19_18453721_ENST00000595066_C10orf76_chr10_103773781_ENST00000370033_length(transcript)=3500nt_BP=170nt
TCGCGCGGCCGAGAGGCTGCAGCGGCAGCAGCTGTCGCGCCAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCGATCCCGCCATGGAGC
AGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTTTGGGGAACACACCGTGAACGCCAGTTGGATTGCAGTTCAGTCTGTGAATC
CTTATATTGTGAAGCTGTCTATCGTGGATGATGAGGCCACACTCAATGGAATGGGACTTGTAATTGCTCAGGCTTTATCTGAGTACAACA
GGCAGTATAAAGACAAGGAAGAAGAACACCAAAGTGGTTTTTTCTCTGCTTTAACAAATATGGTGGGCAGCATGTTCATAGCAGATGCCC
ATGAGAAAATCTCAGTACAAACCAATGAGGCCATTCTTCTGGCACTTTATGAAGCTGTTCATTTAAATCGCAACTTCATCACAGTATTAG
CTCAGAGCCATCCAGAAATGGGCTTGGTGACGACCCCTGTCAGTCCTGCTCCTACAACCCCAGTCACACCACTTGGGACCACACCGCCTT
CCTCTGATGTTATAAGTTCTGTGGAACTCCCACTGGATGCAGATGTACAGACCAGTAATCTACTGATAACCTTTTTAAAGTATAGCTCAA
TTGTCATGCAGGACACCAAAGATGAACACAGGCTTCACAGTGGCAAACTCTGTCTGATTATCCTTACATGTATTGCAGAGGATCAATATG
CCAATGCATTTTTGCATGATGACAACATGAATTTTCGAGTAAACTTACATAGAATGCCTATGAGACACAGGAAGAAGGCAGCAGACAAGA
ATCTTCCCTGCCGTCCTTTAGTATGTGCAGTACTGGACCTGATGGTAGAGTTTATTGTAACACACATGATGAAGGAGTTTCCTATGGATC
TCTATATACGCTGCATCCAGGTAGTACACAAACTGCTCTGCTACCAGAAGAAGTGTCGGGTACGCCTGCATTACACCTGGCGGGAGCTCT
GGTCAGCCTTGATAAATTTGCTGAAGTTCCTTATGTCAAATGAGACTGTACTTTTGGCCAAACACAACATTTTTACATTAGCCCTTATGA
TTGTGAACCTATTTAATATGTTTATCACATATGGCGACACATTTCTGCCAACCCCCAGCAGCTATGATGAACTTTACTATGAGATTATCC
GCATGCACCAGAGCTTTGACAACCTCTACTCCATGGTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGA
CCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGT
CAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACT
CAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCA
GCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCA
TGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTT
CAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTC
CAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTT
TCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAG
ATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCC
AGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCG
CCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGT
AGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCT
CAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTAT
TTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTA
GTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATT
TCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCC
TTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCC
TTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGA
GAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGG
TGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCC
AACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCAC
TGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTT
TGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCC
ATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCT

>64647_64647_2_PGPEP1-C10orf76_PGPEP1_chr19_18453721_ENST00000595066_C10orf76_chr10_103773781_ENST00000370033_length(amino acids)=495AA_BP=28
MEQPRKAVVVTGFGPFGEHTVNASWIAVQSVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIA
DAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKY
SSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFP
MDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYE
IIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYE

--------------------------------------------------------------
>64647_64647_3_PGPEP1-C10orf76_PGPEP1_chr19_18453721_ENST00000597431_C10orf76_chr10_103773781_ENST00000370033_length(transcript)=3460nt_BP=130nt
CAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCGATCCCGCCATGGAGCAGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTT
TGGGGAACACACCGTGAACGCCAGTTGGATTGCAGTTCAGTCTGTGAATCCTTATATTGTGAAGCTGTCTATCGTGGATGATGAGGCCAC
ACTCAATGGAATGGGACTTGTAATTGCTCAGGCTTTATCTGAGTACAACAGGCAGTATAAAGACAAGGAAGAAGAACACCAAAGTGGTTT
TTTCTCTGCTTTAACAAATATGGTGGGCAGCATGTTCATAGCAGATGCCCATGAGAAAATCTCAGTACAAACCAATGAGGCCATTCTTCT
GGCACTTTATGAAGCTGTTCATTTAAATCGCAACTTCATCACAGTATTAGCTCAGAGCCATCCAGAAATGGGCTTGGTGACGACCCCTGT
CAGTCCTGCTCCTACAACCCCAGTCACACCACTTGGGACCACACCGCCTTCCTCTGATGTTATAAGTTCTGTGGAACTCCCACTGGATGC
AGATGTACAGACCAGTAATCTACTGATAACCTTTTTAAAGTATAGCTCAATTGTCATGCAGGACACCAAAGATGAACACAGGCTTCACAG
TGGCAAACTCTGTCTGATTATCCTTACATGTATTGCAGAGGATCAATATGCCAATGCATTTTTGCATGATGACAACATGAATTTTCGAGT
AAACTTACATAGAATGCCTATGAGACACAGGAAGAAGGCAGCAGACAAGAATCTTCCCTGCCGTCCTTTAGTATGTGCAGTACTGGACCT
GATGGTAGAGTTTATTGTAACACACATGATGAAGGAGTTTCCTATGGATCTCTATATACGCTGCATCCAGGTAGTACACAAACTGCTCTG
CTACCAGAAGAAGTGTCGGGTACGCCTGCATTACACCTGGCGGGAGCTCTGGTCAGCCTTGATAAATTTGCTGAAGTTCCTTATGTCAAA
TGAGACTGTACTTTTGGCCAAACACAACATTTTTACATTAGCCCTTATGATTGTGAACCTATTTAATATGTTTATCACATATGGCGACAC
ATTTCTGCCAACCCCCAGCAGCTATGATGAACTTTACTATGAGATTATCCGCATGCACCAGAGCTTTGACAACCTCTACTCCATGGTCCT
GAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGACCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTT
TAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGTCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGA
CACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACTCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGT
TCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCAGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTG
AGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCG
AGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTTCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAG
GGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTCCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGC
CCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTTTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCAC
CCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAGATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGG
CTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCCAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGG
AATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGC
AGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTT
TTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCTCAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCA
AAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTATTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGA
TGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTAGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCT
GGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATTTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAA
ACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCCTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTC
TGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCCTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTT
CCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGAGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGC
CAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGGTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGC
TTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCCAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCC
CTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCACTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAG
AGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTTTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCT
AACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCCATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTC
ATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCTGGTGATAAATCCCCAAGGCAGCTGGATTTGGAGCTGGTGG

>64647_64647_3_PGPEP1-C10orf76_PGPEP1_chr19_18453721_ENST00000597431_C10orf76_chr10_103773781_ENST00000370033_length(amino acids)=495AA_BP=28
MEQPRKAVVVTGFGPFGEHTVNASWIAVQSVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIA
DAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKY
SSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFP
MDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYE
IIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYE

--------------------------------------------------------------
>64647_64647_4_PGPEP1-C10orf76_PGPEP1_chr19_18453721_ENST00000604499_C10orf76_chr10_103773781_ENST00000370033_length(transcript)=3501nt_BP=171nt
CTCGCGCGGCCGAGAGGCTGCAGCGGCAGCAGCTGTCGCGCCAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCGATCCCGCCATGGAG
CAGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTTTGGGGAACACACCGTGAACGCCAGTTGGATTGCAGTTCAGTCTGTGAAT
CCTTATATTGTGAAGCTGTCTATCGTGGATGATGAGGCCACACTCAATGGAATGGGACTTGTAATTGCTCAGGCTTTATCTGAGTACAAC
AGGCAGTATAAAGACAAGGAAGAAGAACACCAAAGTGGTTTTTTCTCTGCTTTAACAAATATGGTGGGCAGCATGTTCATAGCAGATGCC
CATGAGAAAATCTCAGTACAAACCAATGAGGCCATTCTTCTGGCACTTTATGAAGCTGTTCATTTAAATCGCAACTTCATCACAGTATTA
GCTCAGAGCCATCCAGAAATGGGCTTGGTGACGACCCCTGTCAGTCCTGCTCCTACAACCCCAGTCACACCACTTGGGACCACACCGCCT
TCCTCTGATGTTATAAGTTCTGTGGAACTCCCACTGGATGCAGATGTACAGACCAGTAATCTACTGATAACCTTTTTAAAGTATAGCTCA
ATTGTCATGCAGGACACCAAAGATGAACACAGGCTTCACAGTGGCAAACTCTGTCTGATTATCCTTACATGTATTGCAGAGGATCAATAT
GCCAATGCATTTTTGCATGATGACAACATGAATTTTCGAGTAAACTTACATAGAATGCCTATGAGACACAGGAAGAAGGCAGCAGACAAG
AATCTTCCCTGCCGTCCTTTAGTATGTGCAGTACTGGACCTGATGGTAGAGTTTATTGTAACACACATGATGAAGGAGTTTCCTATGGAT
CTCTATATACGCTGCATCCAGGTAGTACACAAACTGCTCTGCTACCAGAAGAAGTGTCGGGTACGCCTGCATTACACCTGGCGGGAGCTC
TGGTCAGCCTTGATAAATTTGCTGAAGTTCCTTATGTCAAATGAGACTGTACTTTTGGCCAAACACAACATTTTTACATTAGCCCTTATG
ATTGTGAACCTATTTAATATGTTTATCACATATGGCGACACATTTCTGCCAACCCCCAGCAGCTATGATGAACTTTACTATGAGATTATC
CGCATGCACCAGAGCTTTGACAACCTCTACTCCATGGTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTG
ACCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTG
TCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTAC
TCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTC
AGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATC
ATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACT
TCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCT
CCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATT
TTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCA
GATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTC
CAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTC
GCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAG
TAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTC
TCAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTA
TTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTT
AGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAAT
TTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCC
CTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCC
CTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAG
AGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGG
GTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCC
CAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCA
CTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCT
TTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGC
CATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCC

>64647_64647_4_PGPEP1-C10orf76_PGPEP1_chr19_18453721_ENST00000604499_C10orf76_chr10_103773781_ENST00000370033_length(amino acids)=495AA_BP=28
MEQPRKAVVVTGFGPFGEHTVNASWIAVQSVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIA
DAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKY
SSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFP
MDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYE
IIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGPEP1-C10orf76


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGPEP1-C10orf76


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGPEP1-C10orf76


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource