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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PHC3-NFKBIL1 (FusionGDB2 ID:64747)

Fusion Gene Summary for PHC3-NFKBIL1

Fusion gene summary

Fusion gene information	Fusion gene name: PHC3-NFKBIL1
	Fusion gene ID: 64747
		Hgene	Tgene
	Gene symbol	PHC3	NFKBIL1
	Gene ID	80012	4795
	Gene name	polyhomeotic homolog 3	NFKB inhibitor like 1
	Synonyms	EDR3\|HPH3	IKBL\|NFKBIL
	Cytomap	3q26.2	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	polyhomeotic-like protein 3early development regulator 3early development regulatory protein 3homolog of polyhomeotic 3polyhomeotic like 3	NF-kappa-B inhibitor-like protein 1I-kappa-B-like proteinikappaBLinhibitor of kappa B-like proteinnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000467570, ENST00000474275, ENST00000494943, ENST00000495893, ENST00000481639, ENST00000497658,	ENST00000383500, ENST00000400279, ENST00000400285, ENST00000414391, ENST00000419122, ENST00000419623, ENST00000421396, ENST00000424652, ENST00000428467, ENST00000430501, ENST00000432160, ENST00000434332, ENST00000442947, ENST00000451911, ENST00000455376, ENST00000460420, ENST00000464328, ENST00000466313, ENST00000480619, ENST00000496344, ENST00000376145, ENST00000376148,
Fusion gene scores	* DoF score	15 X 15 X 11=2475	1 X 1 X 1=1
	# samples	20	1
	** MAII score	log2(20/2475*10)=-3.62935662007961 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: PHC3 [Title/Abstract] AND NFKBIL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PHC3(169889161)-NFKBIL1(31515940), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NFKBIL1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	20829348
Tgene	NFKBIL1	GO:0032088	negative regulation of NF-kappaB transcription factor activity	20829348
Tgene	NFKBIL1	GO:0034122	negative regulation of toll-like receptor signaling pathway	20829348
Tgene	NFKBIL1	GO:0071222	cellular response to lipopolysaccharide	20829348

Fusion gene breakpoints across PHC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NFKBIL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-NA-A4QX-01A	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
ChimerDB4	UCS	TCGA-NA-A4QX	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+

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Fusion Gene ORF analysis for PHC3-NFKBIL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000467570	ENST00000383500	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000400279	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000400285	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000414391	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000419122	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000419623	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000421396	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000424652	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000428467	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000430501	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000432160	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000434332	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000442947	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000451911	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000455376	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000460420	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000464328	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000466313	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000480619	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000467570	ENST00000496344	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000383500	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000400279	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000400285	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000414391	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000419122	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000419623	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000421396	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000424652	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000428467	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000430501	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000432160	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000434332	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000442947	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000451911	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000455376	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000460420	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000464328	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000466313	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000480619	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000474275	ENST00000496344	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000383500	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000400279	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000400285	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000414391	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000419122	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000419623	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000421396	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000424652	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000428467	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000430501	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000432160	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000434332	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000442947	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000451911	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000455376	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000460420	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000464328	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000466313	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000480619	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000494943	ENST00000496344	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000383500	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000400279	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000400285	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000414391	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000419122	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000419623	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000421396	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000424652	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000428467	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000430501	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000432160	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000434332	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000442947	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000451911	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000455376	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000460420	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000464328	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000466313	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000480619	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
5CDS-intron	ENST00000495893	ENST00000496344	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
In-frame	ENST00000467570	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
In-frame	ENST00000467570	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
In-frame	ENST00000474275	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
In-frame	ENST00000474275	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
In-frame	ENST00000494943	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
In-frame	ENST00000494943	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
In-frame	ENST00000495893	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
In-frame	ENST00000495893	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-3CDS	ENST00000481639	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-3CDS	ENST00000481639	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-3CDS	ENST00000497658	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-3CDS	ENST00000497658	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000383500	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000400279	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000400285	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000414391	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000419122	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000419623	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000421396	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000424652	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000428467	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000430501	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000432160	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000434332	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000442947	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000451911	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000455376	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000460420	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000464328	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000466313	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000480619	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000481639	ENST00000496344	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000383500	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000400279	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000400285	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000414391	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000419122	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000419623	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000421396	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000424652	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000428467	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000430501	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000432160	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000434332	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000442947	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000451911	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000455376	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000460420	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000464328	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000466313	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000480619	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+
intron-intron	ENST00000497658	ENST00000496344	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000495893	PHC3	chr3	169889161	-	ENST00000376148	NFKBIL1	chr6	31515940	+	1753	446	32	1534	500
ENST00000495893	PHC3	chr3	169889161	-	ENST00000376145	NFKBIL1	chr6	31515940	+	1708	446	32	1489	485
ENST00000494943	PHC3	chr3	169889161	-	ENST00000376148	NFKBIL1	chr6	31515940	+	1754	447	69	1535	488
ENST00000494943	PHC3	chr3	169889161	-	ENST00000376145	NFKBIL1	chr6	31515940	+	1709	447	69	1490	473
ENST00000467570	PHC3	chr3	169889161	-	ENST00000376148	NFKBIL1	chr6	31515940	+	1755	448	34	1536	500
ENST00000467570	PHC3	chr3	169889161	-	ENST00000376145	NFKBIL1	chr6	31515940	+	1710	448	34	1491	485
ENST00000474275	PHC3	chr3	169889161	-	ENST00000376148	NFKBIL1	chr6	31515940	+	1737	430	64	1518	484
ENST00000474275	PHC3	chr3	169889161	-	ENST00000376145	NFKBIL1	chr6	31515940	+	1692	430	64	1473	469

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000495893	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+	0.16972338	0.83027655
ENST00000495893	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+	0.18289599	0.81710404
ENST00000494943	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+	0.17837144	0.8216285
ENST00000494943	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+	0.18592215	0.81407785
ENST00000467570	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+	0.16665275	0.8333472
ENST00000467570	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+	0.17809452	0.8219055
ENST00000474275	ENST00000376148	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+	0.18988958	0.81011045
ENST00000474275	ENST00000376145	PHC3	chr3	169889161	-	NFKBIL1	chr6	31515940	+	0.20225078	0.7977493

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Fusion Genomic Features for PHC3-NFKBIL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PHC3	chr3	169889160	-	NFKBIL1	chr6	31515939	+	1.51E-11	1
PHC3	chr3	169889160	-	NFKBIL1	chr6	31515939	+	1.51E-11	1
PHC3	chr3	169889160	-	NFKBIL1	chr6	31515939	+	1.51E-11	1
PHC3	chr3	169889160	-	NFKBIL1	chr6	31515939	+	1.51E-11	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHC3-NFKBIL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:169889161/chr6:31515940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000474275

19_26

122

187.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000494943

19_26

126

984.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000495893

19_26

138

996.0

Compositional bias

Note=Poly-Thr

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000376148

64_93

382.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000376148

97_130

382.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000383500

64_93

367.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000383500

97_130

367.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000400279

64_93

359.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000400279

97_130

359.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000400285

64_93

382.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000400285

97_130

382.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000414391

64_93

367.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000414391

97_130

367.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000419122

64_93

382.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000419122

97_130

382.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000419623

64_93

367.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000419623

97_130

367.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000421396

64_93

367.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000421396

97_130

367.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000424652

64_93

382.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000424652

97_130

382.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000428467

64_93

359.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000428467

97_130

359.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000430501

64_93

367.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000430501

97_130

367.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000432160

64_93

382.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000432160

97_130

382.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000434332

64_93

359.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000434332

97_130

359.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000442947

64_93

382.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000442947

97_130

382.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000451911

64_93

367.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000451911

97_130

367.0

Repeat

Note=ANK 2

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000455376

64_93

382.0

Repeat

Note=ANK 1

Tgene

NFKBIL1

chr3:169889161

chr6:31515940

ENST00000455376

97_130

382.0

Repeat

Note=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000474275

324_539

122

187.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000474275

346_670

122

187.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000474275

89_287

122

187.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000494943

324_539

126

984.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000494943

346_670

126

984.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000494943

89_287

126

984.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000495893

324_539

138

996.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000495893

346_670

138

996.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000495893

89_287

138

996.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000497658

19_26

152.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000497658

324_539

152.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000497658

346_670

152.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000497658

89_287

152.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000474275

919_983

122

187.0

Domain

SAM

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000494943

919_983

126

984.0

Domain

SAM

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000495893

919_983

138

996.0

Domain

SAM

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000497658

919_983

152.0

Domain

SAM

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000474275

691_720

122

187.0

Motif

Note=HD1

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000494943

691_720

126

984.0

Motif

Note=HD1

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000495893

691_720

138

996.0

Motif

Note=HD1

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000497658

691_720

152.0

Motif

Note=HD1

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000474275

776_810

122

187.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000494943

776_810

126

984.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000495893

776_810

138

996.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169889161

chr6:31515940

ENST00000497658

776_810

152.0

Zinc finger

FCS-type

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Fusion Gene Sequence for PHC3-NFKBIL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64747_64747_1_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000467570_NFKBIL1_chr6_31515940_ENST00000376145_length(transcript)=1710nt_BP=448nt
ATGCGCAGCCCATGTTAGTGATGGAGGAGAGAAGATGGCGGAAGCGGAATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCC
GGGAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTC
TGTCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCA
AATGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGC
TGCTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCC
CAAGAGTTCCATGGCCTCCACTTCCCGCCGCCAACGCCGAGAACGTCGCTTTCGTCGTTACTTGTCTGCAGGACGGCTGGTCCGGGCCCA
GGCCCTCCTCCAGCGACACCCAGGCCTCGATGTAGATGCTGGGCAGCCCCCACCACTGCACCGGGCCTGTGCCCGCCACGATGCCCCTGC
CCTGTGCCTGCTGCTTCGGCTCGGGGCTGACCCTGCCCACCAGGACCGCCATGGGGACACGGCACTGCATGCTGCTGCCCGCCAGGGCCC
AGATGCCTACACCGATTTCTTCCTCCCGCTGCTAAGCCGCTGTCCCTCCGCCATGGGAATAAAGAATAAGGATGGGGAGACCCCTGGCCA
AATTTTGGGCTGGGGACCCCCCTGGGATTCTGCTGAAGAGGAGGAAGAAGATGATGCCTCCAAGGAGCGGGAATGGAGACAGAAGCTCCA
GGGTGATGCCTCCCATGAAACCCAGGAACCTGAGTCCTTCTCAGCCTGGTCAGATCGCCTGGCCCGGGAACATGCCCAGAAGTGCCAGCA
GCAGCAGCGAGAAGCAGAGGGATCCCGTCGACCCCCACGTGCTGAGGGCTCCAGCCAGAGCTGGCGACAGCAGGAGGAGGAGCAGCGGCT
CTTCAGGGAGCGAGCCCGGGCCAAGGAGGAAGAGCTGCGTGAGAGCCGAGCCAGGAGGGCGCAGGAGGCTCTAGGGGACCGAGAACCCAA
GCCAACCAGGGCCGGGCCCAGGGAAGAGCACCCCAGAGGAGCGGGGAGGGGCAGCCTCTGGCGATTTGGTGATGTGCCCTGGCCCTGCCC
TGGGGGAGGGGACCCAGAGGCCATGGCTGCAGCCCTGGTGGCCAGGGGCCCCCCTTTGGAGGAACAGGGGGCTCTGAGGAGGTACTTGAG
GGTCCAGCAGGTCCGCTGGCACCCTGACCGCTTCCTGCAGCGATTCCGAAGCCAGATTGAGACCTGGGAGCTGGGCCGTGTGATGGGAGC
AGTGACAGCCCTTTCTCAGGCCCTGAATCGCCATGCAGAGGCCCTCAAGTGACCCTAGGGAAGAAGCAAGAAACTTCGGGGCTGCAGCCT
CAGGATGAGGCAGAAGGAAGGGTAAGGGAAAGGATGGGGACCACAAGGAAGAGCCAGGTGCTGCTCAGCAGAGGATATGGGTGGGAGCGA
AAGTTGTAACAAGTGGGGGTGGGGGGTGCGGGCCGCCACCACTGCTCCTTGACTCTGCCGTTTCCTAATAAGACCTGGTTCCACATCTCA

>64747_64747_1_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000467570_NFKBIL1_chr6_31515940_ENST00000376145_length(amino acids)=485AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDV
DAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSA
EEEEEDDASKEREWRQKLQGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQEEEQRLFRERARAKEEE
LRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRF

--------------------------------------------------------------
>64747_64747_2_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000467570_NFKBIL1_chr6_31515940_ENST00000376148_length(transcript)=1755nt_BP=448nt
ATGCGCAGCCCATGTTAGTGATGGAGGAGAGAAGATGGCGGAAGCGGAATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCC
GGGAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTC
TGTCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCA
AATGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGC
TGCTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCC
CAAGAGTTCCATGGCCTCCACTTCCCGCCGCCAACGCCGAGAACGTCGCTTTCGTCGTTACTTGTCTGCAGGACGGCTGGTCCGGGCCCA
GGCCCTCCTCCAGCGACACCCAGGCCTCGATGTAGATGCTGGGCAGCCCCCACCACTGCACCGGGCCTGTGCCCGCCACGATGCCCCTGC
CCTGTGCCTGCTGCTTCGGCTCGGGGCTGACCCTGCCCACCAGGACCGCCATGGGGACACGGCACTGCATGCTGCTGCCCGCCAGGGCCC
AGATGCCTACACCGATTTCTTCCTCCCGCTGCTAAGCCGCTGTCCCTCCGCCATGGGAATAAAGAATAAGGATGGGGAGACCCCTGGCCA
AATTTTGGGCTGGGGACCCCCCTGGGATTCTGCTGAAGAGGAGGAAGAAGATGATGCCTCCAAGGAGCGGGAATGGAGACAGAAGCTCCA
GGGTGAGCTGGAGGACGAGTGGCAGGAAGTCATGGGGAGGTTTGAAGGTGATGCCTCCCATGAAACCCAGGAACCTGAGTCCTTCTCAGC
CTGGTCAGATCGCCTGGCCCGGGAACATGCCCAGAAGTGCCAGCAGCAGCAGCGAGAAGCAGAGGGATCCCGTCGACCCCCACGTGCTGA
GGGCTCCAGCCAGAGCTGGCGACAGCAGGAGGAGGAGCAGCGGCTCTTCAGGGAGCGAGCCCGGGCCAAGGAGGAAGAGCTGCGTGAGAG
CCGAGCCAGGAGGGCGCAGGAGGCTCTAGGGGACCGAGAACCCAAGCCAACCAGGGCCGGGCCCAGGGAAGAGCACCCCAGAGGAGCGGG
GAGGGGCAGCCTCTGGCGATTTGGTGATGTGCCCTGGCCCTGCCCTGGGGGAGGGGACCCAGAGGCCATGGCTGCAGCCCTGGTGGCCAG
GGGCCCCCCTTTGGAGGAACAGGGGGCTCTGAGGAGGTACTTGAGGGTCCAGCAGGTCCGCTGGCACCCTGACCGCTTCCTGCAGCGATT
CCGAAGCCAGATTGAGACCTGGGAGCTGGGCCGTGTGATGGGAGCAGTGACAGCCCTTTCTCAGGCCCTGAATCGCCATGCAGAGGCCCT
CAAGTGACCCTAGGGAAGAAGCAAGAAACTTCGGGGCTGCAGCCTCAGGATGAGGCAGAAGGAAGGGTAAGGGAAAGGATGGGGACCACA
AGGAAGAGCCAGGTGCTGCTCAGCAGAGGATATGGGTGGGAGCGAAAGTTGTAACAAGTGGGGGTGGGGGGTGCGGGCCGCCACCACTGC

>64747_64747_2_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000467570_NFKBIL1_chr6_31515940_ENST00000376148_length(amino acids)=500AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDV
DAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSA
EEEEEDDASKEREWRQKLQGELEDEWQEVMGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQEE
EQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALR

--------------------------------------------------------------
>64747_64747_3_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000474275_NFKBIL1_chr6_31515940_ENST00000376145_length(transcript)=1692nt_BP=430nt
TGGAGGAGAGAAGATGGCGGAAGCGGAGTGAGTGACTAGATGATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCGGGAAC
ATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCTGTCTA
CAGTGGTTCAGACCGACATGCTGTACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAAATGTATGCAGCCCAACA
ACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCTGCTGTTCAGGCAAGTTT
GTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCCCAAGAGTTCCATGGCCTC
CACTTCCCGCCGCCAACGCCGAGAACGTCGCTTTCGTCGTTACTTGTCTGCAGGACGGCTGGTCCGGGCCCAGGCCCTCCTCCAGCGACA
CCCAGGCCTCGATGTAGATGCTGGGCAGCCCCCACCACTGCACCGGGCCTGTGCCCGCCACGATGCCCCTGCCCTGTGCCTGCTGCTTCG
GCTCGGGGCTGACCCTGCCCACCAGGACCGCCATGGGGACACGGCACTGCATGCTGCTGCCCGCCAGGGCCCAGATGCCTACACCGATTT
CTTCCTCCCGCTGCTAAGCCGCTGTCCCTCCGCCATGGGAATAAAGAATAAGGATGGGGAGACCCCTGGCCAAATTTTGGGCTGGGGACC
CCCCTGGGATTCTGCTGAAGAGGAGGAAGAAGATGATGCCTCCAAGGAGCGGGAATGGAGACAGAAGCTCCAGGGTGATGCCTCCCATGA
AACCCAGGAACCTGAGTCCTTCTCAGCCTGGTCAGATCGCCTGGCCCGGGAACATGCCCAGAAGTGCCAGCAGCAGCAGCGAGAAGCAGA
GGGATCCCGTCGACCCCCACGTGCTGAGGGCTCCAGCCAGAGCTGGCGACAGCAGGAGGAGGAGCAGCGGCTCTTCAGGGAGCGAGCCCG
GGCCAAGGAGGAAGAGCTGCGTGAGAGCCGAGCCAGGAGGGCGCAGGAGGCTCTAGGGGACCGAGAACCCAAGCCAACCAGGGCCGGGCC
CAGGGAAGAGCACCCCAGAGGAGCGGGGAGGGGCAGCCTCTGGCGATTTGGTGATGTGCCCTGGCCCTGCCCTGGGGGAGGGGACCCAGA
GGCCATGGCTGCAGCCCTGGTGGCCAGGGGCCCCCCTTTGGAGGAACAGGGGGCTCTGAGGAGGTACTTGAGGGTCCAGCAGGTCCGCTG
GCACCCTGACCGCTTCCTGCAGCGATTCCGAAGCCAGATTGAGACCTGGGAGCTGGGCCGTGTGATGGGAGCAGTGACAGCCCTTTCTCA
GGCCCTGAATCGCCATGCAGAGGCCCTCAAGTGACCCTAGGGAAGAAGCAAGAAACTTCGGGGCTGCAGCCTCAGGATGAGGCAGAAGGA
AGGGTAAGGGAAAGGATGGGGACCACAAGGAAGAGCCAGGTGCTGCTCAGCAGAGGATATGGGTGGGAGCGAAAGTTGTAACAAGTGGGG

>64747_64747_3_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000474275_NFKBIL1_chr6_31515940_ENST00000376145_length(amino acids)=469AA_BP=122
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQ
SLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDVDAGQPPPLHRACARHD
APALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQ
KLQGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQEEEQRLFRERARAKEEELRESRARRAQEALGDR
EPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELGRV

--------------------------------------------------------------
>64747_64747_4_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000474275_NFKBIL1_chr6_31515940_ENST00000376148_length(transcript)=1737nt_BP=430nt
TGGAGGAGAGAAGATGGCGGAAGCGGAGTGAGTGACTAGATGATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCGGGAAC
ATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCTGTCTA
CAGTGGTTCAGACCGACATGCTGTACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAAATGTATGCAGCCCAACA
ACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCTGCTGTTCAGGCAAGTTT
GTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCCCAAGAGTTCCATGGCCTC
CACTTCCCGCCGCCAACGCCGAGAACGTCGCTTTCGTCGTTACTTGTCTGCAGGACGGCTGGTCCGGGCCCAGGCCCTCCTCCAGCGACA
CCCAGGCCTCGATGTAGATGCTGGGCAGCCCCCACCACTGCACCGGGCCTGTGCCCGCCACGATGCCCCTGCCCTGTGCCTGCTGCTTCG
GCTCGGGGCTGACCCTGCCCACCAGGACCGCCATGGGGACACGGCACTGCATGCTGCTGCCCGCCAGGGCCCAGATGCCTACACCGATTT
CTTCCTCCCGCTGCTAAGCCGCTGTCCCTCCGCCATGGGAATAAAGAATAAGGATGGGGAGACCCCTGGCCAAATTTTGGGCTGGGGACC
CCCCTGGGATTCTGCTGAAGAGGAGGAAGAAGATGATGCCTCCAAGGAGCGGGAATGGAGACAGAAGCTCCAGGGTGAGCTGGAGGACGA
GTGGCAGGAAGTCATGGGGAGGTTTGAAGGTGATGCCTCCCATGAAACCCAGGAACCTGAGTCCTTCTCAGCCTGGTCAGATCGCCTGGC
CCGGGAACATGCCCAGAAGTGCCAGCAGCAGCAGCGAGAAGCAGAGGGATCCCGTCGACCCCCACGTGCTGAGGGCTCCAGCCAGAGCTG
GCGACAGCAGGAGGAGGAGCAGCGGCTCTTCAGGGAGCGAGCCCGGGCCAAGGAGGAAGAGCTGCGTGAGAGCCGAGCCAGGAGGGCGCA
GGAGGCTCTAGGGGACCGAGAACCCAAGCCAACCAGGGCCGGGCCCAGGGAAGAGCACCCCAGAGGAGCGGGGAGGGGCAGCCTCTGGCG
ATTTGGTGATGTGCCCTGGCCCTGCCCTGGGGGAGGGGACCCAGAGGCCATGGCTGCAGCCCTGGTGGCCAGGGGCCCCCCTTTGGAGGA
ACAGGGGGCTCTGAGGAGGTACTTGAGGGTCCAGCAGGTCCGCTGGCACCCTGACCGCTTCCTGCAGCGATTCCGAAGCCAGATTGAGAC
CTGGGAGCTGGGCCGTGTGATGGGAGCAGTGACAGCCCTTTCTCAGGCCCTGAATCGCCATGCAGAGGCCCTCAAGTGACCCTAGGGAAG
AAGCAAGAAACTTCGGGGCTGCAGCCTCAGGATGAGGCAGAAGGAAGGGTAAGGGAAAGGATGGGGACCACAAGGAAGAGCCAGGTGCTG
CTCAGCAGAGGATATGGGTGGGAGCGAAAGTTGTAACAAGTGGGGGTGGGGGGTGCGGGCCGCCACCACTGCTCCTTGACTCTGCCGTTT

>64747_64747_4_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000474275_NFKBIL1_chr6_31515940_ENST00000376148_length(amino acids)=484AA_BP=122
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQ
SLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDVDAGQPPPLHRACARHD
APALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQ
KLQGELEDEWQEVMGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQEEEQRLFRERARAKEEEL
RESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFL

--------------------------------------------------------------
>64747_64747_5_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000494943_NFKBIL1_chr6_31515940_ENST00000376145_length(transcript)=1709nt_BP=447nt
AGTGATGGAGGAGAGAAGATGGCGGAAGCGGAGTGAGTGACTAGATGATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCG
GGAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCT
GTCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAA
ATGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCT
GCTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCCC
AAGAGTTCCATGGCCTCCACTTCCCGCCGCCAACGCCGAGAACGTCGCTTTCGTCGTTACTTGTCTGCAGGACGGCTGGTCCGGGCCCAG
GCCCTCCTCCAGCGACACCCAGGCCTCGATGTAGATGCTGGGCAGCCCCCACCACTGCACCGGGCCTGTGCCCGCCACGATGCCCCTGCC
CTGTGCCTGCTGCTTCGGCTCGGGGCTGACCCTGCCCACCAGGACCGCCATGGGGACACGGCACTGCATGCTGCTGCCCGCCAGGGCCCA
GATGCCTACACCGATTTCTTCCTCCCGCTGCTAAGCCGCTGTCCCTCCGCCATGGGAATAAAGAATAAGGATGGGGAGACCCCTGGCCAA
ATTTTGGGCTGGGGACCCCCCTGGGATTCTGCTGAAGAGGAGGAAGAAGATGATGCCTCCAAGGAGCGGGAATGGAGACAGAAGCTCCAG
GGTGATGCCTCCCATGAAACCCAGGAACCTGAGTCCTTCTCAGCCTGGTCAGATCGCCTGGCCCGGGAACATGCCCAGAAGTGCCAGCAG
CAGCAGCGAGAAGCAGAGGGATCCCGTCGACCCCCACGTGCTGAGGGCTCCAGCCAGAGCTGGCGACAGCAGGAGGAGGAGCAGCGGCTC
TTCAGGGAGCGAGCCCGGGCCAAGGAGGAAGAGCTGCGTGAGAGCCGAGCCAGGAGGGCGCAGGAGGCTCTAGGGGACCGAGAACCCAAG
CCAACCAGGGCCGGGCCCAGGGAAGAGCACCCCAGAGGAGCGGGGAGGGGCAGCCTCTGGCGATTTGGTGATGTGCCCTGGCCCTGCCCT
GGGGGAGGGGACCCAGAGGCCATGGCTGCAGCCCTGGTGGCCAGGGGCCCCCCTTTGGAGGAACAGGGGGCTCTGAGGAGGTACTTGAGG
GTCCAGCAGGTCCGCTGGCACCCTGACCGCTTCCTGCAGCGATTCCGAAGCCAGATTGAGACCTGGGAGCTGGGCCGTGTGATGGGAGCA
GTGACAGCCCTTTCTCAGGCCCTGAATCGCCATGCAGAGGCCCTCAAGTGACCCTAGGGAAGAAGCAAGAAACTTCGGGGCTGCAGCCTC
AGGATGAGGCAGAAGGAAGGGTAAGGGAAAGGATGGGGACCACAAGGAAGAGCCAGGTGCTGCTCAGCAGAGGATATGGGTGGGAGCGAA

>64747_64747_5_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000494943_NFKBIL1_chr6_31515940_ENST00000376145_length(amino acids)=473AA_BP=126
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDVDAGQPPPLHRAC
ARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKER
EWRQKLQGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQEEEQRLFRERARAKEEELRESRARRAQEA
LGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWE

--------------------------------------------------------------
>64747_64747_6_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000494943_NFKBIL1_chr6_31515940_ENST00000376148_length(transcript)=1754nt_BP=447nt
AGTGATGGAGGAGAGAAGATGGCGGAAGCGGAGTGAGTGACTAGATGATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCG
GGAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCT
GTCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAA
ATGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCT
GCTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCCC
AAGAGTTCCATGGCCTCCACTTCCCGCCGCCAACGCCGAGAACGTCGCTTTCGTCGTTACTTGTCTGCAGGACGGCTGGTCCGGGCCCAG
GCCCTCCTCCAGCGACACCCAGGCCTCGATGTAGATGCTGGGCAGCCCCCACCACTGCACCGGGCCTGTGCCCGCCACGATGCCCCTGCC
CTGTGCCTGCTGCTTCGGCTCGGGGCTGACCCTGCCCACCAGGACCGCCATGGGGACACGGCACTGCATGCTGCTGCCCGCCAGGGCCCA
GATGCCTACACCGATTTCTTCCTCCCGCTGCTAAGCCGCTGTCCCTCCGCCATGGGAATAAAGAATAAGGATGGGGAGACCCCTGGCCAA
ATTTTGGGCTGGGGACCCCCCTGGGATTCTGCTGAAGAGGAGGAAGAAGATGATGCCTCCAAGGAGCGGGAATGGAGACAGAAGCTCCAG
GGTGAGCTGGAGGACGAGTGGCAGGAAGTCATGGGGAGGTTTGAAGGTGATGCCTCCCATGAAACCCAGGAACCTGAGTCCTTCTCAGCC
TGGTCAGATCGCCTGGCCCGGGAACATGCCCAGAAGTGCCAGCAGCAGCAGCGAGAAGCAGAGGGATCCCGTCGACCCCCACGTGCTGAG
GGCTCCAGCCAGAGCTGGCGACAGCAGGAGGAGGAGCAGCGGCTCTTCAGGGAGCGAGCCCGGGCCAAGGAGGAAGAGCTGCGTGAGAGC
CGAGCCAGGAGGGCGCAGGAGGCTCTAGGGGACCGAGAACCCAAGCCAACCAGGGCCGGGCCCAGGGAAGAGCACCCCAGAGGAGCGGGG
AGGGGCAGCCTCTGGCGATTTGGTGATGTGCCCTGGCCCTGCCCTGGGGGAGGGGACCCAGAGGCCATGGCTGCAGCCCTGGTGGCCAGG
GGCCCCCCTTTGGAGGAACAGGGGGCTCTGAGGAGGTACTTGAGGGTCCAGCAGGTCCGCTGGCACCCTGACCGCTTCCTGCAGCGATTC
CGAAGCCAGATTGAGACCTGGGAGCTGGGCCGTGTGATGGGAGCAGTGACAGCCCTTTCTCAGGCCCTGAATCGCCATGCAGAGGCCCTC
AAGTGACCCTAGGGAAGAAGCAAGAAACTTCGGGGCTGCAGCCTCAGGATGAGGCAGAAGGAAGGGTAAGGGAAAGGATGGGGACCACAA
GGAAGAGCCAGGTGCTGCTCAGCAGAGGATATGGGTGGGAGCGAAAGTTGTAACAAGTGGGGGTGGGGGGTGCGGGCCGCCACCACTGCT

>64747_64747_6_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000494943_NFKBIL1_chr6_31515940_ENST00000376148_length(amino acids)=488AA_BP=126
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDVDAGQPPPLHRAC
ARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKER
EWRQKLQGELEDEWQEVMGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQEEEQRLFRERARAK
EEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHP

--------------------------------------------------------------
>64747_64747_7_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000495893_NFKBIL1_chr6_31515940_ENST00000376145_length(transcript)=1708nt_BP=446nt
GCGCAGCCCATGTTAGTGATGGAGGAGAGAAGATGGCGGAAGCGGAATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCGG
GAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCTG
TCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAAA
TGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCTG
CTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCCCA
AGAGTTCCATGGCCTCCACTTCCCGCCGCCAACGCCGAGAACGTCGCTTTCGTCGTTACTTGTCTGCAGGACGGCTGGTCCGGGCCCAGG
CCCTCCTCCAGCGACACCCAGGCCTCGATGTAGATGCTGGGCAGCCCCCACCACTGCACCGGGCCTGTGCCCGCCACGATGCCCCTGCCC
TGTGCCTGCTGCTTCGGCTCGGGGCTGACCCTGCCCACCAGGACCGCCATGGGGACACGGCACTGCATGCTGCTGCCCGCCAGGGCCCAG
ATGCCTACACCGATTTCTTCCTCCCGCTGCTAAGCCGCTGTCCCTCCGCCATGGGAATAAAGAATAAGGATGGGGAGACCCCTGGCCAAA
TTTTGGGCTGGGGACCCCCCTGGGATTCTGCTGAAGAGGAGGAAGAAGATGATGCCTCCAAGGAGCGGGAATGGAGACAGAAGCTCCAGG
GTGATGCCTCCCATGAAACCCAGGAACCTGAGTCCTTCTCAGCCTGGTCAGATCGCCTGGCCCGGGAACATGCCCAGAAGTGCCAGCAGC
AGCAGCGAGAAGCAGAGGGATCCCGTCGACCCCCACGTGCTGAGGGCTCCAGCCAGAGCTGGCGACAGCAGGAGGAGGAGCAGCGGCTCT
TCAGGGAGCGAGCCCGGGCCAAGGAGGAAGAGCTGCGTGAGAGCCGAGCCAGGAGGGCGCAGGAGGCTCTAGGGGACCGAGAACCCAAGC
CAACCAGGGCCGGGCCCAGGGAAGAGCACCCCAGAGGAGCGGGGAGGGGCAGCCTCTGGCGATTTGGTGATGTGCCCTGGCCCTGCCCTG
GGGGAGGGGACCCAGAGGCCATGGCTGCAGCCCTGGTGGCCAGGGGCCCCCCTTTGGAGGAACAGGGGGCTCTGAGGAGGTACTTGAGGG
TCCAGCAGGTCCGCTGGCACCCTGACCGCTTCCTGCAGCGATTCCGAAGCCAGATTGAGACCTGGGAGCTGGGCCGTGTGATGGGAGCAG
TGACAGCCCTTTCTCAGGCCCTGAATCGCCATGCAGAGGCCCTCAAGTGACCCTAGGGAAGAAGCAAGAAACTTCGGGGCTGCAGCCTCA
GGATGAGGCAGAAGGAAGGGTAAGGGAAAGGATGGGGACCACAAGGAAGAGCCAGGTGCTGCTCAGCAGAGGATATGGGTGGGAGCGAAA

>64747_64747_7_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000495893_NFKBIL1_chr6_31515940_ENST00000376145_length(amino acids)=485AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDV
DAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSA
EEEEEDDASKEREWRQKLQGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQEEEQRLFRERARAKEEE
LRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRF

--------------------------------------------------------------
>64747_64747_8_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000495893_NFKBIL1_chr6_31515940_ENST00000376148_length(transcript)=1753nt_BP=446nt
GCGCAGCCCATGTTAGTGATGGAGGAGAGAAGATGGCGGAAGCGGAATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCGG
GAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCTG
TCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAAA
TGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCTG
CTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCCCA
AGAGTTCCATGGCCTCCACTTCCCGCCGCCAACGCCGAGAACGTCGCTTTCGTCGTTACTTGTCTGCAGGACGGCTGGTCCGGGCCCAGG
CCCTCCTCCAGCGACACCCAGGCCTCGATGTAGATGCTGGGCAGCCCCCACCACTGCACCGGGCCTGTGCCCGCCACGATGCCCCTGCCC
TGTGCCTGCTGCTTCGGCTCGGGGCTGACCCTGCCCACCAGGACCGCCATGGGGACACGGCACTGCATGCTGCTGCCCGCCAGGGCCCAG
ATGCCTACACCGATTTCTTCCTCCCGCTGCTAAGCCGCTGTCCCTCCGCCATGGGAATAAAGAATAAGGATGGGGAGACCCCTGGCCAAA
TTTTGGGCTGGGGACCCCCCTGGGATTCTGCTGAAGAGGAGGAAGAAGATGATGCCTCCAAGGAGCGGGAATGGAGACAGAAGCTCCAGG
GTGAGCTGGAGGACGAGTGGCAGGAAGTCATGGGGAGGTTTGAAGGTGATGCCTCCCATGAAACCCAGGAACCTGAGTCCTTCTCAGCCT
GGTCAGATCGCCTGGCCCGGGAACATGCCCAGAAGTGCCAGCAGCAGCAGCGAGAAGCAGAGGGATCCCGTCGACCCCCACGTGCTGAGG
GCTCCAGCCAGAGCTGGCGACAGCAGGAGGAGGAGCAGCGGCTCTTCAGGGAGCGAGCCCGGGCCAAGGAGGAAGAGCTGCGTGAGAGCC
GAGCCAGGAGGGCGCAGGAGGCTCTAGGGGACCGAGAACCCAAGCCAACCAGGGCCGGGCCCAGGGAAGAGCACCCCAGAGGAGCGGGGA
GGGGCAGCCTCTGGCGATTTGGTGATGTGCCCTGGCCCTGCCCTGGGGGAGGGGACCCAGAGGCCATGGCTGCAGCCCTGGTGGCCAGGG
GCCCCCCTTTGGAGGAACAGGGGGCTCTGAGGAGGTACTTGAGGGTCCAGCAGGTCCGCTGGCACCCTGACCGCTTCCTGCAGCGATTCC
GAAGCCAGATTGAGACCTGGGAGCTGGGCCGTGTGATGGGAGCAGTGACAGCCCTTTCTCAGGCCCTGAATCGCCATGCAGAGGCCCTCA
AGTGACCCTAGGGAAGAAGCAAGAAACTTCGGGGCTGCAGCCTCAGGATGAGGCAGAAGGAAGGGTAAGGGAAAGGATGGGGACCACAAG
GAAGAGCCAGGTGCTGCTCAGCAGAGGATATGGGTGGGAGCGAAAGTTGTAACAAGTGGGGGTGGGGGGTGCGGGCCGCCACCACTGCTC

>64747_64747_8_PHC3-NFKBIL1_PHC3_chr3_169889161_ENST00000495893_NFKBIL1_chr6_31515940_ENST00000376148_length(amino acids)=500AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDV
DAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSA
EEEEEDDASKEREWRQKLQGELEDEWQEVMGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQEE
EQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PHC3-NFKBIL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PHC3-NFKBIL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PHC3-NFKBIL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source