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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:PHC3-SLC7A14 (FusionGDB2 ID:64752)

Fusion Gene Summary for PHC3-SLC7A14

Fusion gene summary

Fusion gene information	Fusion gene name: PHC3-SLC7A14
	Fusion gene ID: 64752
		Hgene	Tgene
	Gene symbol	PHC3	SLC7A14
	Gene ID	80012	57709
	Gene name	polyhomeotic homolog 3	solute carrier family 7 member 14
	Synonyms	EDR3\|HPH3	PPP1R142
	Cytomap	3q26.2	3q26.2
	Type of gene	protein-coding	protein-coding
	Description	polyhomeotic-like protein 3early development regulator 3early development regulatory protein 3homolog of polyhomeotic 3polyhomeotic like 3	probable cationic amino acid transporterprotein phosphatase 1, regulatory subunit 142solute carrier family 7 (cationic amino acid transporter, y+ system), member 14solute carrier family 7 (orphan transporter), member 14
	Modification date	20200313	20200315
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000467570, ENST00000474275, ENST00000481639, ENST00000494943, ENST00000495893, ENST00000497658,	ENST00000466168, ENST00000231706,
Fusion gene scores	* DoF score	15 X 15 X 11=2475	4 X 4 X 5=80
	# samples	20	8
	** MAII score	log2(20/2475*10)=-3.62935662007961 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/80*10)=0
Context	PubMed: PHC3 [Title/Abstract] AND SLC7A14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PHC3(169896561)-SLC7A14(170185165), # samples:2 PHC3(169854207)-SLC7A14(170185165), # samples:2
Anticipated loss of major functional domain due to fusion event.	PHC3-SLC7A14 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. PHC3-SLC7A14 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PHC3-SLC7A14 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. PHC3-SLC7A14 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SLC7A14	GO:0010923	negative regulation of phosphatase activity	19389623

Fusion gene breakpoints across PHC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC7A14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-G7-6793-01A	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
ChimerDB4	LIHC	TCGA-2Y-A9H0-01A	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
ChimerDB4	LIHC	TCGA-2Y-A9H0	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
ChimerDB4	LUSC	TCGA-94-7943-01A	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
ChimerDB4	LUSC	TCGA-94-7943	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-

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Fusion Gene ORF analysis for PHC3-SLC7A14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000467570	ENST00000466168	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000467570	ENST00000466168	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000467570	ENST00000466168	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000474275	ENST00000466168	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000481639	ENST00000466168	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000494943	ENST00000466168	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000494943	ENST00000466168	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000494943	ENST00000466168	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000495893	ENST00000466168	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000495893	ENST00000466168	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000495893	ENST00000466168	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
5CDS-intron	ENST00000497658	ENST00000466168	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000467570	ENST00000231706	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000467570	ENST00000231706	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000474275	ENST00000231706	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000481639	ENST00000231706	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000494943	ENST00000231706	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000494943	ENST00000231706	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000495893	ENST00000231706	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000495893	ENST00000231706	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
Frame-shift	ENST00000497658	ENST00000231706	PHC3	chr3	169896561	-	SLC7A14	chr3	170185165	-
In-frame	ENST00000467570	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
In-frame	ENST00000494943	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
In-frame	ENST00000495893	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
intron-3CDS	ENST00000474275	ENST00000231706	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
intron-3CDS	ENST00000474275	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
intron-3CDS	ENST00000481639	ENST00000231706	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
intron-3CDS	ENST00000481639	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
intron-3CDS	ENST00000497658	ENST00000231706	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
intron-3CDS	ENST00000497658	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
intron-intron	ENST00000474275	ENST00000466168	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
intron-intron	ENST00000474275	ENST00000466168	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
intron-intron	ENST00000481639	ENST00000466168	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
intron-intron	ENST00000481639	ENST00000466168	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-
intron-intron	ENST00000497658	ENST00000466168	PHC3	chr3	169863211	-	SLC7A14	chr3	170185165	-
intron-intron	ENST00000497658	ENST00000466168	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000495893	PHC3	chr3	169854207	-	ENST00000231706	SLC7A14	chr3	170185165	-	8745	951	32	1273	413
ENST00000494943	PHC3	chr3	169854207	-	ENST00000231706	SLC7A14	chr3	170185165	-	8746	952	69	1274	401
ENST00000467570	PHC3	chr3	169854207	-	ENST00000231706	SLC7A14	chr3	170185165	-	8588	794	34	1116	360

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000495893	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-	0.001152437	0.9988476
ENST00000494943	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-	0.001745231	0.9982547
ENST00000467570	ENST00000231706	PHC3	chr3	169854207	-	SLC7A14	chr3	170185165	-	0.000683511	0.99931645

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Fusion Genomic Features for PHC3-SLC7A14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHC3-SLC7A14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:169896561/chr3:170185165)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000494943

19_26

294

984.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000494943

89_287

294

984.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000495893

19_26

306

996.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000495893

89_287

306

996.0

Compositional bias

Note=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000474275

19_26

187.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000474275

324_539

187.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000474275

346_670

187.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000474275

89_287

187.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000494943

324_539

294

984.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000494943

346_670

294

984.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000495893

324_539

306

996.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000495893

346_670

306

996.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000497658

19_26

152.0

Compositional bias

Note=Poly-Thr

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000497658

324_539

152.0

Compositional bias

Note=Gln-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000497658

346_670

152.0

Compositional bias

Note=Pro-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000497658

89_287

152.0

Compositional bias

Note=Ser-rich

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000474275

919_983

187.0

Domain

SAM

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000494943

919_983

294

984.0

Domain

SAM

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000495893

919_983

306

996.0

Domain

SAM

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000497658

919_983

152.0

Domain

SAM

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000474275

691_720

187.0

Motif

Note=HD1

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000494943

691_720

294

984.0

Motif

Note=HD1

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000495893

691_720

306

996.0

Motif

Note=HD1

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000497658

691_720

152.0

Motif

Note=HD1

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000474275

776_810

187.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000494943

776_810

294

984.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000495893

776_810

306

996.0

Zinc finger

FCS-type

Hgene

PHC3

chr3:169854207

chr3:170185165

ENST00000497658

776_810

152.0

Zinc finger

FCS-type

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

119_141

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

187_207

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

216_236

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

251_271

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

291_311

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

336_356

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

360_380

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

384_404

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

407_427

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

565_585

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

58_78

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

596_616

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

628_648

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

655_675

664

772.0

Transmembrane

Helical

Tgene

SLC7A14

chr3:169854207

chr3:170185165

ENST00000231706

83_103

664

772.0

Transmembrane

Helical

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Fusion Gene Sequence for PHC3-SLC7A14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64752_64752_1_PHC3-SLC7A14_PHC3_chr3_169854207_ENST00000467570_SLC7A14_chr3_170185165_ENST00000231706_length(transcript)=8588nt_BP=794nt
ATGCGCAGCCCATGTTAGTGATGGAGGAGAGAAGATGGCGGAAGCGGAATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCC
GGGAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTC
TGTCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCA
AATGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGC
TGCTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTCT
GATTTTCACACCCGCTACCACTGTGGCTGCTGTACAGTCTGACATTCCTGTTGTCTCGTCGTCATCGTCATCTTCCTGTCAGTCTGCAGC
TACTCAGGTTCAGAATTTAACATTACGCAGCCAGAAGTTGGGTGTATTATCTAGCTCACAGAATGGTCCACCAAAAAGCACTAGTCAAAC
TCAGTCATTGACAATTTGTCATAACAAAACAACAGTGACCAGTTCTAAAATCAGCCAACGAGATCCTTCTCCAGAAAGTAATAAGAAAGG
AGAGAGCCCAAGCCTGGAATCACGAAGCACAGCTGTCACCCGGACATCAAGTATTCACCAGTTAATAGCACCAGGTCTGCTCATTTATTT
TGGATATGGCATCTGGAACAGCACCCTGGAAATCAGCGCTCGAGAAGAGGCCCTGCACCAAAGCACGTACCAACGCTACGACGTGGATGA
CCCCTTCTCAGTGGAGGAGGGTTTCTCCTACGCCACAGAGGGCGAGAGCCAGGAGGACTGGGGCGGGCCCACTGAAGACAAAGGCTTCTA
TTACCAACAGATGTCAGATGCGAAGGCAAACGGCCGGACAAGTAGCAAAGCGAAGAGCAAAAGCAAACACAAACAGAACTCAGAGGCCCT
GATTGCAAATGATGAGTTAGATTACTCTCCAGAGTAGGAGAAACACACAAGTGGGTAGAAATGGTGATGACTGATTTTCAGTAACTTAAC
CTGTGGGCTAGAAGGTGAAAACTTTTTTGGCTCTCATTTCACAAATCCAGCCTTCCCCAAATTCAATCCCTAGTCATAGCCTGTCATTTG
CTACTTTTGCTCTTCAGGATAGTTCTGTTGAAGGGCTTAACCTGGGTCCCCTAACTGGTCGCCTTGTTAAATAAAATAAATAAATAAACA
AGAGGCTATATGAAATTCCATCTTAGGTGCAACCACCAGAGCTGATGGTACCAAATGTTTCCTAGGCCTTTGCTTTGCTGGTTGAAGCCC
AAGCAGGGGCTCTGGGCAGAAGGCAGAATTTCAGTCACCTGAGACATGGGGACAAAGCTCTGTTCTTGGCATGTCAGGCTGAGTGCTGCT
CCCCGAGGTCAGGGTGGGTAGATGGGCATTGGCACTTCCTGAGCAAGCATCATTTTATCCTGCAATCTCACCCAAAATTAATTCATGGAA
AAGACACATGCTTCTTTTTATTCACCAACATTCTCACAGCTTCCAAACTATAATTTTAGGATCCAGCAAAGTTCAGGGACTCTGGACCAT
TTTCCCAATGGTTTCAGATTCACCATAAAGCAGTCAGGCAGACCCAGTGATATGGTAAGAAGCACCATCAAAGCTCTATGTAAATGCCCA
GAAGAAAATTAAATAACCATATCTTGCGGTAAAAGCCAGAAGGGCATTGGCAGAAATTAACTCTCTGTCATGGCCTCTCTTATATCAGAC
TGCAGCTCCTGGTGATATGATGAAAGCGGGCAAAGGTGGAGCATGATTTCATGGCACTGATATGCCTTGAAAAAGTAGGTTGTTTGTTTT
ATAATCAGATAAAAATTTTTACAAGGAGAAGTGAGCCAGCCACTGAGATCACATTGCAAATTCTCTTTCATATTTCTAAAATTATAAATT
CTAAAGTTTTTGAGATAGGCAACCACTTGATTGGTGTGTGCTACTCTGAAAACAAAATAGGCTGAAGTATAGCGACTTAGGTAGTTGCAT
TCCATGAGATCACATTTCACTTCTGAACCTTATTCCTTGGGGCTAGCTCACTTTCAGAGGTGTATTTTTTTTTCCTGTTATTTCCCAGAG
TAGTTTCACTGAAGCCCAGAGAAATATCTACCTGGTAAGATGTAAATTTGGGCCATAAAAGGGGCTATTAAAAGAATTTTCTCAGAAATA
GAATAGATGAGAGAATTTGCAAAGGAAAAAAACACACATGGGCTACAATATAAATTCTACTCTTGGGTTACAAGAATTCCTGTGGCTGCA
CTGAGATACGTACAAATGTATGTGAAGGCACAATTTGAATCAAGCTATCATAGAATTAACCAAGCTATTAAAATTAATCAAGCTATTAAT
AAAATCTCTGTGAGGATTTCCTGAAAGAGGGACAAAAGAAGAAATTCCTTGTCCTTTCTCTCCTGGATGTATCAGTATGCCAAACGTTTT
CCAGAACATATTCGCTAGCACTCAAGTCTGTTCTTTCTGAAAGGCTGAGGCTCATGCCATCTTGGCATGCTTTAGGATTATGGCAAGGAG
GTAAAAGTCCATTTTTTCATTCAACTAACACTGGTTGAGAATAGACCCAATGCTAAGTGACAGGAATGAATAGAAGCATGGCACTTGCCC
TTGGGGGCTACAGTCCATGGATGAGCAGCACTGGAGCCTGGTAAATGCAGATAAAACAACAAACTTGACAAGTCTCCAGGCTGATGCACT
GGGTTTTAACATACATATAAAGATGAATTGAAACTAGTTTTTAAAAAATATGCTTTAAATAAATTACATATCGTAATCATAGCCAATGTA
TACCATTAAACTAAAATAACTGCAATTTTCTAGATATTTTTTATTCTTCTGTAGTCATTGTTTAGAACTCTGGTTTCCTGAGGTCATTTT
GTCATTTTAATATCATGCTTGACAATGCTATGTTTTCTCTTCCCTAGAGTTAACCATAAAGATACAGTGCCTACTCTGTGAAATACAGCA
TTAGGAATTAATTATAAACTAATTATCAGTCATCTTTTGAAAACAAAGTTTTGAATTGGCTATAGGACTCAACAAATCTGCCTGGTGTAA
ATAGAATCTGTTAAGCTTGATACATATCTAGATAGATGAGGAGGGGTTGTATTCATTAAGCATGAGAATAGAGAAATAGGAGTGCAAAAT
GGCAAAATCTTAACGTGGGTGAAAGAGCTTCCTTTTACTAGTGAGGTTTAAGTATTAAAGTAACAATAGCCTGGTGGCAGATGAATGCAA
TTTCTATAGGATGGGAATGGAAAATGTATGCTTTGGTTAACACCATTGCTGTTGACTTCATGCAGATTCTATTAAGCACTCTCATTTCAG
GAGCCATTTTTCCCACATAGTATATTAGTATATTTTAAGCTTAGCTCCCTTTATTTTTCTAAAGTTGATAAATCACCTCCCTAGCAACCT
TAGTTTTAAAAAAAAAATCACTAAGATAGAAAAAGTATTTTCAGGTACATAGACATGTTTGTCCTCAGGTTTACCTGCTTCTGTGAACAG
TCCCAGATTTTACAATGCAGTTTTCAAATACCATCAATCACTACAATGACAATATTACTATTTTCTTAACAGGTTTCTAAACGATGTATG
TGTGGGATCACATTAAAAGTAAGATCACCTTATAATTATCTTAGAAACTTTGCCCCTTGAAGGGAGTCCAAGGAAGACCTACATTTTATT
GAATTCTGAATAGCAAAAGCTCTCCGAGTGAGATTTCATTGTGTGGATTTGTGGTTTGGAGCCAATTACTTGATTTTCTTCAGATTTTAT
TCTACTTATTTATTGGTACTCTGCTTCATTTCAAAAGGATTTGAGGCAGCTACTAAAATATATATAATACAAAACAAAAATTAAGTGAGG
AACTCAGAGCAAACAAAAATAGAAACAGAAAGGATAAGACAAAACTAGACGTATATTTAGTACATAAATGCAGAACCCTGACATGCTTTA
CTAAATTTGCCAATGAGTGACACCATGAAAAATAATAGAATTAGTGGTAATGACAAGAAGAAGTACTTCTGCATGATAAGAACAAATCTT
TCCCCATGCAGGTAGAGGTTTGAAATAGCATAGATCATTAAAATCCACAGGTAAGCTTCAAACCTAGATTTTGCTAGCTACATGTGCCTG
GCATATAGTGTGTATTCAAGAAATACCTGATGATTGACAGAATGAATGAATTGGAGGAAAATGAAATATTTATTCAACAATTACTTGTGG
AGTGCCTATTATGTACTATGGCAGATATTGATATCGTAAGTCAGATAAAAATCCAGCTCTTAAGAAGTAGAGGAAATAGAGCTTGGTGTG
GTGGCATGTGCCTATGATCCCAGATAGTTGAGAGACTGAGGGAGGAGGATCACTTGAGCCCAGGAGTTCAAGGCTGCAGTGAGCTATGAT
CACACCACTGTACTCCAGCCTGGGTAACAGAAGAATACCCTGTCTCTTAAAAAGGAAAATCAAATAGGGGAAATGGGATATATAAATAAA
GAACAATAGTGAATGTGTCAGGTGAGATGACGGACTTGTAATGTGCTGTGGGGGGTCAAATATGAAGAAGGCCTTCTTCCTCTGGAAAGG
TCATAAAGAATGTCACACTTGTGTTGGAACTTGTGAAGTGGGTAGAATTTTATCAAGTAGAAATGAGAGAAAGGCATGCCAAGCAAAGGA
TCGGCATGAATAAGGTCTACTAGTTTGTGGTCCTCTGGCTAAGAATTTGTGCTGTGCCTCCATTAAGAGAAAGCAAGGAGCTAGTTTGCC
TGGAGCACATGATTTATGCATGACTTATACATGCAACAATAAGAAATAATGCTAGGAAGGCAGGTGAGGGATCACTCACAGAGAGACTTG
AATGTCACACTGAGCTGACTGGCTTTCCTCGGGTGAGAGAGTGGGAAATAATTGGGGAACTGACGAAAGTGTGAATCCAGGAAGGCTGAA
CTTTAAGAAAGCTGAGACGGTGGCTTCCTTACCTATGCAAGGAACTAACAAGCCACATATACACTCCAAATTGATTTAACAAATTAAAGA
GAAAAATAGCTGTACTTTGAGTCCTGTGTCTGCATTCATCATTAACCTAAGAAAATACAGCCATTTAATACGTGGACAAGCAACACAATT
TAACAGCCACTTTAAAGTTTTCAACAATAGGTTTCAACAACTAAACCTAACAACTTTTTATATCTATCTAATCTAAACAGTAAAATCTCA
GCTCCAGGTTTTACTGAGCTTGAGTGCTACTTTTTTTTTTTTAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATC
TTGGCTCACTGCAACCTTCACCTCCCGGGTTCAAGCTATTCTCCTGCCTCAGCCTCCCAAGCAGCTGGGATTATAGGCGTGTGCCAGTTC
TACTTCTTAGTAACAAACTAGTAGCTAATCAAATGCCTACATAATGGTCATGATAAATCTGTTTAAATAAATGGCGGGCGGAAGGGAGTT
GTTGAATTTAACAATCCATCCTTCTTCAGAATCTATAGGTCAGCCAGAATATAAATCTAGTAATTATTGAAAAACAAAACACAAACTCCT
TCAAAGAAATCTCTCTCCTCTATTCTGCTGAAAAGGGTTGGTAAACCTGACATCCTTTCTTTTATTGGAAGACAAATCCAACATTTGTTA
GACATCCAACATTTGTTGGAAGTCTACCTTACAAGAAACCACCTCTTATCTGCAACATAAACAGAAGCTACATCAGGTTGAAAATCCACA
TAGAAGACTGGAGAAAATTGCCGTCCCCTTTCGCACTAGGTTTTACCAGGGGCCCAAGATGTCAGAGGAAAGTCCGCGGAGGGCCAAACA
CAGGTTTACCTAATTATGAATCTCAGATTAGAATGTCTTATTGTGTGGAAAAGTCAGAACTCAGGAAATGTGTCTGAAGCCAGAGCGGGG
GTCTGCTTACGGAGTCTACGCAGCGGGTAGGGGTCCACTATTGGAGTATAAACCTCAGGTCAGTGAGTAGTGCAGAGGTGTCCCTAACTT
CCAATGGAGGGAAAGAGAGGAGAGCAAAGGAAACACATCCAGAAGTCGCCACGAGGGCTGTGTGCCAGCGCTCCATTTTCATGCTGTTTG
GAACAAGACGTGTCAAGGAAGATGTTTCTATCCAAAGTCTTCATGGAGCCTCTGCTTCCCCTGTACCTGTGTAGCTCCCTGAAACTGAGG
ACCCACGTGTCTGCAAAGACCTCTGGAGATCCTAAGAGAGAGAGGCACCAGCAGGTAACCAGTGGTGGCCTGGCCACGAAAGAGTATTTG
AAATTCAACAGTGAGCAAGTGCAGAAACAGCATCCCAAACCGCAGGCCCCACCACACGCAGGAACCAGAAAGCTGAAGTTTCACCAAGGA
GTTTACTTAGTATTTCTCGCTGGGAATGGGGATGGGTAGCAAAAAGCCCCTTTCATGTACATAATGGTTGGTCCTATGTCCTACTTTTAT
TTTCTCTAAGAGTTTTAGAAGAAAGGCTGTTTTAATTTTTTTTTCTCCTTAAGAGCAACTTCCTTTTTAAAATGCTTTCCTCTTCTTGTC
CTGCTTGAGTAATGCAGGCATCATTCTGAAATCATTCTGAAACAGCTAGGCAGTCGCCTTTTGCCAAAATTACTTCTCTAAGAAAATAGA
GTGTTCTTTTTTTTAGGACTTAGAACCCACAAGGGGTGAGTGGAAGTTTTGTAGCCCATCAAAGGTGAATATGTGTTCTGCAGTATCAAC
TAAAACAGTGTACAAAATCATTAAACTGGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATC
ACCTGAGGCCAGGAGTTCAAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAGGTGTGGTGTTGC
ATGCCTGTAATCCCAGCTATTAGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGTCGAGATCACACCA
TTGCACTCCAGCCTGGGCAATAAGAGCAAAACTCCGTCTCAAAAATAATAATAATAATAATTTAACTGTGTTCTGCACACACAGAATTAC
AAAATCCCTATAGGACTTTCACAGATAGCTTTGGGCTTAAGGTCTTCGGACAACAGGTAGTTCTAATTTCTTACTCTTTGGGACATTTAG
TACATGTTGGTACACATAAGGAAAGAAAATGGCTTATATTAGAGCTAGGAAACAGGGGCAGCCTGGATTTTTATGGTAGGAACTCACTCT
GTGCTTTTTTTTTTTTCTGTTAAGTTTTCTTGACACTGACTTCGGTAACATTGGCTAAAGGGAATTGTGAGTCATGTGAATTTCACCTGC
AGTGCAGACTTTAAAGGACTGTGTTCATTCTGATTTGGGGATGAAGAGAATGTTCCATGCACATCTATTGATTGGTCTTGGCAGTTGCTG
ATACGCTTGTCTCATTCACACTCCCAAAGGCGAGGATTTACCCTAGAAATCATAAACCCCCACTTTCCAAAGCAAAGATGCTGTTAATGT
TATGATGGTGCATAAATACCTCAACTGTCTGGGCTGAGAGAGGGGGCTGCAGGTTTTTAAGAGAGCAGCTATAGTCCTCATTCCATGTAG
TCACATCATCTGATGACAGGACTCCACATTCTAGCTTTTCTCACTGTGGAAAAGAAACGTTACTGTTTAATTAATATCCAAAGTTATAAA
TACAGCTTGTAAATTTTACTAACTTGTTTCTTTTTCGTTTCGTCCTTGAGAAGTACAACTTGCATTTACAGATGGTAATTCCTAGTGTTG
TTCTCTGCTATCTTTTTTTGGTATGAAATTGCTGTATTTGTTAAAGTTTGTTCGTTTTGTGGTTTTTAATTCCCATTGGTGTGCTGTACA
ATGTAGTGTATCATGAAGAAAGAAATAATATGCAGATGTATTATGAAATGTGTTTTATTTTCAAATGTGTGGTGTTGACAATATATTGAT
TTATCAAGATACTAAGGGAAAATTCTAAATTTAACAAAATGTGTATATTTTAATAAATGCATAAAGCTTTATTGTGTGCCTTTAAATTTA
AAAATGGGTTTATAAAGAAAGTCAGAAACAAAAGTGTCTTACTATAAAATATCCATAGTAATGTAAAGCTTTTACACGAGACTACCAAAA
AAAAAGAAAGAAAAGAAAAAGGAGCCTTCCCATATTTTGTTAACCTTAACCAGTATCTGAAGTCTGTTACTTTTTTTCCATTCTTAAATG
GAGATGAATAAGTGAATTTCGCCTTAAGTGTTTCAATTGTCCTTTGTAGAAAAGCCAGATAAATGAGTTCACTTTGAATTGCATTATTGT

>64752_64752_1_PHC3-SLC7A14_PHC3_chr3_169854207_ENST00000467570_SLC7A14_chr3_170185165_ENST00000231706_length(amino acids)=360AA_BP=253
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQ
KLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPGLLIYFGYGIWNSTLEI
SAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPTEDKGFYYQQMSDAKANGRTSSKAKSKSKHKQNSEALIANDELDYSPE

--------------------------------------------------------------
>64752_64752_2_PHC3-SLC7A14_PHC3_chr3_169854207_ENST00000494943_SLC7A14_chr3_170185165_ENST00000231706_length(transcript)=8746nt_BP=952nt
AGTGATGGAGGAGAGAAGATGGCGGAAGCGGAGTGAGTGACTAGATGATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCG
GGAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCT
GTCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAA
ATGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCT
GCTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTATC
AACCTCTCCACTTCTCCTACACCTGCACAGTTAATAAGCCGTTCCCAGGCTTCCAGTTCTACCAGCGGCAGTATTACCCAACAGACTATG
TTACTAGGGAGTACTTCCCCTACCCTAACGGCAAGCCAAGCTCAAATGTATCTCCGAGCTCAAATGCTGATTTTCACACCCGCTACCACT
GTGGCTGCTGTACAGTCTGACATTCCTGTTGTCTCGTCGTCATCGTCATCTTCCTGTCAGTCTGCAGCTACTCAGGTTCAGAATTTAACA
TTACGCAGCCAGAAGTTGGGTGTATTATCTAGCTCACAGAATGGTCCACCAAAAAGCACTAGTCAAACTCAGTCATTGACAATTTGTCAT
AACAAAACAACAGTGACCAGTTCTAAAATCAGCCAACGAGATCCTTCTCCAGAAAGTAATAAGAAAGGAGAGAGCCCAAGCCTGGAATCA
CGAAGCACAGCTGTCACCCGGACATCAAGTATTCACCAGTTAATAGCACCAGGTCTGCTCATTTATTTTGGATATGGCATCTGGAACAGC
ACCCTGGAAATCAGCGCTCGAGAAGAGGCCCTGCACCAAAGCACGTACCAACGCTACGACGTGGATGACCCCTTCTCAGTGGAGGAGGGT
TTCTCCTACGCCACAGAGGGCGAGAGCCAGGAGGACTGGGGCGGGCCCACTGAAGACAAAGGCTTCTATTACCAACAGATGTCAGATGCG
AAGGCAAACGGCCGGACAAGTAGCAAAGCGAAGAGCAAAAGCAAACACAAACAGAACTCAGAGGCCCTGATTGCAAATGATGAGTTAGAT
TACTCTCCAGAGTAGGAGAAACACACAAGTGGGTAGAAATGGTGATGACTGATTTTCAGTAACTTAACCTGTGGGCTAGAAGGTGAAAAC
TTTTTTGGCTCTCATTTCACAAATCCAGCCTTCCCCAAATTCAATCCCTAGTCATAGCCTGTCATTTGCTACTTTTGCTCTTCAGGATAG
TTCTGTTGAAGGGCTTAACCTGGGTCCCCTAACTGGTCGCCTTGTTAAATAAAATAAATAAATAAACAAGAGGCTATATGAAATTCCATC
TTAGGTGCAACCACCAGAGCTGATGGTACCAAATGTTTCCTAGGCCTTTGCTTTGCTGGTTGAAGCCCAAGCAGGGGCTCTGGGCAGAAG
GCAGAATTTCAGTCACCTGAGACATGGGGACAAAGCTCTGTTCTTGGCATGTCAGGCTGAGTGCTGCTCCCCGAGGTCAGGGTGGGTAGA
TGGGCATTGGCACTTCCTGAGCAAGCATCATTTTATCCTGCAATCTCACCCAAAATTAATTCATGGAAAAGACACATGCTTCTTTTTATT
CACCAACATTCTCACAGCTTCCAAACTATAATTTTAGGATCCAGCAAAGTTCAGGGACTCTGGACCATTTTCCCAATGGTTTCAGATTCA
CCATAAAGCAGTCAGGCAGACCCAGTGATATGGTAAGAAGCACCATCAAAGCTCTATGTAAATGCCCAGAAGAAAATTAAATAACCATAT
CTTGCGGTAAAAGCCAGAAGGGCATTGGCAGAAATTAACTCTCTGTCATGGCCTCTCTTATATCAGACTGCAGCTCCTGGTGATATGATG
AAAGCGGGCAAAGGTGGAGCATGATTTCATGGCACTGATATGCCTTGAAAAAGTAGGTTGTTTGTTTTATAATCAGATAAAAATTTTTAC
AAGGAGAAGTGAGCCAGCCACTGAGATCACATTGCAAATTCTCTTTCATATTTCTAAAATTATAAATTCTAAAGTTTTTGAGATAGGCAA
CCACTTGATTGGTGTGTGCTACTCTGAAAACAAAATAGGCTGAAGTATAGCGACTTAGGTAGTTGCATTCCATGAGATCACATTTCACTT
CTGAACCTTATTCCTTGGGGCTAGCTCACTTTCAGAGGTGTATTTTTTTTTCCTGTTATTTCCCAGAGTAGTTTCACTGAAGCCCAGAGA
AATATCTACCTGGTAAGATGTAAATTTGGGCCATAAAAGGGGCTATTAAAAGAATTTTCTCAGAAATAGAATAGATGAGAGAATTTGCAA
AGGAAAAAAACACACATGGGCTACAATATAAATTCTACTCTTGGGTTACAAGAATTCCTGTGGCTGCACTGAGATACGTACAAATGTATG
TGAAGGCACAATTTGAATCAAGCTATCATAGAATTAACCAAGCTATTAAAATTAATCAAGCTATTAATAAAATCTCTGTGAGGATTTCCT
GAAAGAGGGACAAAAGAAGAAATTCCTTGTCCTTTCTCTCCTGGATGTATCAGTATGCCAAACGTTTTCCAGAACATATTCGCTAGCACT
CAAGTCTGTTCTTTCTGAAAGGCTGAGGCTCATGCCATCTTGGCATGCTTTAGGATTATGGCAAGGAGGTAAAAGTCCATTTTTTCATTC
AACTAACACTGGTTGAGAATAGACCCAATGCTAAGTGACAGGAATGAATAGAAGCATGGCACTTGCCCTTGGGGGCTACAGTCCATGGAT
GAGCAGCACTGGAGCCTGGTAAATGCAGATAAAACAACAAACTTGACAAGTCTCCAGGCTGATGCACTGGGTTTTAACATACATATAAAG
ATGAATTGAAACTAGTTTTTAAAAAATATGCTTTAAATAAATTACATATCGTAATCATAGCCAATGTATACCATTAAACTAAAATAACTG
CAATTTTCTAGATATTTTTTATTCTTCTGTAGTCATTGTTTAGAACTCTGGTTTCCTGAGGTCATTTTGTCATTTTAATATCATGCTTGA
CAATGCTATGTTTTCTCTTCCCTAGAGTTAACCATAAAGATACAGTGCCTACTCTGTGAAATACAGCATTAGGAATTAATTATAAACTAA
TTATCAGTCATCTTTTGAAAACAAAGTTTTGAATTGGCTATAGGACTCAACAAATCTGCCTGGTGTAAATAGAATCTGTTAAGCTTGATA
CATATCTAGATAGATGAGGAGGGGTTGTATTCATTAAGCATGAGAATAGAGAAATAGGAGTGCAAAATGGCAAAATCTTAACGTGGGTGA
AAGAGCTTCCTTTTACTAGTGAGGTTTAAGTATTAAAGTAACAATAGCCTGGTGGCAGATGAATGCAATTTCTATAGGATGGGAATGGAA
AATGTATGCTTTGGTTAACACCATTGCTGTTGACTTCATGCAGATTCTATTAAGCACTCTCATTTCAGGAGCCATTTTTCCCACATAGTA
TATTAGTATATTTTAAGCTTAGCTCCCTTTATTTTTCTAAAGTTGATAAATCACCTCCCTAGCAACCTTAGTTTTAAAAAAAAAATCACT
AAGATAGAAAAAGTATTTTCAGGTACATAGACATGTTTGTCCTCAGGTTTACCTGCTTCTGTGAACAGTCCCAGATTTTACAATGCAGTT
TTCAAATACCATCAATCACTACAATGACAATATTACTATTTTCTTAACAGGTTTCTAAACGATGTATGTGTGGGATCACATTAAAAGTAA
GATCACCTTATAATTATCTTAGAAACTTTGCCCCTTGAAGGGAGTCCAAGGAAGACCTACATTTTATTGAATTCTGAATAGCAAAAGCTC
TCCGAGTGAGATTTCATTGTGTGGATTTGTGGTTTGGAGCCAATTACTTGATTTTCTTCAGATTTTATTCTACTTATTTATTGGTACTCT
GCTTCATTTCAAAAGGATTTGAGGCAGCTACTAAAATATATATAATACAAAACAAAAATTAAGTGAGGAACTCAGAGCAAACAAAAATAG
AAACAGAAAGGATAAGACAAAACTAGACGTATATTTAGTACATAAATGCAGAACCCTGACATGCTTTACTAAATTTGCCAATGAGTGACA
CCATGAAAAATAATAGAATTAGTGGTAATGACAAGAAGAAGTACTTCTGCATGATAAGAACAAATCTTTCCCCATGCAGGTAGAGGTTTG
AAATAGCATAGATCATTAAAATCCACAGGTAAGCTTCAAACCTAGATTTTGCTAGCTACATGTGCCTGGCATATAGTGTGTATTCAAGAA
ATACCTGATGATTGACAGAATGAATGAATTGGAGGAAAATGAAATATTTATTCAACAATTACTTGTGGAGTGCCTATTATGTACTATGGC
AGATATTGATATCGTAAGTCAGATAAAAATCCAGCTCTTAAGAAGTAGAGGAAATAGAGCTTGGTGTGGTGGCATGTGCCTATGATCCCA
GATAGTTGAGAGACTGAGGGAGGAGGATCACTTGAGCCCAGGAGTTCAAGGCTGCAGTGAGCTATGATCACACCACTGTACTCCAGCCTG
GGTAACAGAAGAATACCCTGTCTCTTAAAAAGGAAAATCAAATAGGGGAAATGGGATATATAAATAAAGAACAATAGTGAATGTGTCAGG
TGAGATGACGGACTTGTAATGTGCTGTGGGGGGTCAAATATGAAGAAGGCCTTCTTCCTCTGGAAAGGTCATAAAGAATGTCACACTTGT
GTTGGAACTTGTGAAGTGGGTAGAATTTTATCAAGTAGAAATGAGAGAAAGGCATGCCAAGCAAAGGATCGGCATGAATAAGGTCTACTA
GTTTGTGGTCCTCTGGCTAAGAATTTGTGCTGTGCCTCCATTAAGAGAAAGCAAGGAGCTAGTTTGCCTGGAGCACATGATTTATGCATG
ACTTATACATGCAACAATAAGAAATAATGCTAGGAAGGCAGGTGAGGGATCACTCACAGAGAGACTTGAATGTCACACTGAGCTGACTGG
CTTTCCTCGGGTGAGAGAGTGGGAAATAATTGGGGAACTGACGAAAGTGTGAATCCAGGAAGGCTGAACTTTAAGAAAGCTGAGACGGTG
GCTTCCTTACCTATGCAAGGAACTAACAAGCCACATATACACTCCAAATTGATTTAACAAATTAAAGAGAAAAATAGCTGTACTTTGAGT
CCTGTGTCTGCATTCATCATTAACCTAAGAAAATACAGCCATTTAATACGTGGACAAGCAACACAATTTAACAGCCACTTTAAAGTTTTC
AACAATAGGTTTCAACAACTAAACCTAACAACTTTTTATATCTATCTAATCTAAACAGTAAAATCTCAGCTCCAGGTTTTACTGAGCTTG
AGTGCTACTTTTTTTTTTTTAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTTCACC
TCCCGGGTTCAAGCTATTCTCCTGCCTCAGCCTCCCAAGCAGCTGGGATTATAGGCGTGTGCCAGTTCTACTTCTTAGTAACAAACTAGT
AGCTAATCAAATGCCTACATAATGGTCATGATAAATCTGTTTAAATAAATGGCGGGCGGAAGGGAGTTGTTGAATTTAACAATCCATCCT
TCTTCAGAATCTATAGGTCAGCCAGAATATAAATCTAGTAATTATTGAAAAACAAAACACAAACTCCTTCAAAGAAATCTCTCTCCTCTA
TTCTGCTGAAAAGGGTTGGTAAACCTGACATCCTTTCTTTTATTGGAAGACAAATCCAACATTTGTTAGACATCCAACATTTGTTGGAAG
TCTACCTTACAAGAAACCACCTCTTATCTGCAACATAAACAGAAGCTACATCAGGTTGAAAATCCACATAGAAGACTGGAGAAAATTGCC
GTCCCCTTTCGCACTAGGTTTTACCAGGGGCCCAAGATGTCAGAGGAAAGTCCGCGGAGGGCCAAACACAGGTTTACCTAATTATGAATC
TCAGATTAGAATGTCTTATTGTGTGGAAAAGTCAGAACTCAGGAAATGTGTCTGAAGCCAGAGCGGGGGTCTGCTTACGGAGTCTACGCA
GCGGGTAGGGGTCCACTATTGGAGTATAAACCTCAGGTCAGTGAGTAGTGCAGAGGTGTCCCTAACTTCCAATGGAGGGAAAGAGAGGAG
AGCAAAGGAAACACATCCAGAAGTCGCCACGAGGGCTGTGTGCCAGCGCTCCATTTTCATGCTGTTTGGAACAAGACGTGTCAAGGAAGA
TGTTTCTATCCAAAGTCTTCATGGAGCCTCTGCTTCCCCTGTACCTGTGTAGCTCCCTGAAACTGAGGACCCACGTGTCTGCAAAGACCT
CTGGAGATCCTAAGAGAGAGAGGCACCAGCAGGTAACCAGTGGTGGCCTGGCCACGAAAGAGTATTTGAAATTCAACAGTGAGCAAGTGC
AGAAACAGCATCCCAAACCGCAGGCCCCACCACACGCAGGAACCAGAAAGCTGAAGTTTCACCAAGGAGTTTACTTAGTATTTCTCGCTG
GGAATGGGGATGGGTAGCAAAAAGCCCCTTTCATGTACATAATGGTTGGTCCTATGTCCTACTTTTATTTTCTCTAAGAGTTTTAGAAGA
AAGGCTGTTTTAATTTTTTTTTCTCCTTAAGAGCAACTTCCTTTTTAAAATGCTTTCCTCTTCTTGTCCTGCTTGAGTAATGCAGGCATC
ATTCTGAAATCATTCTGAAACAGCTAGGCAGTCGCCTTTTGCCAAAATTACTTCTCTAAGAAAATAGAGTGTTCTTTTTTTTAGGACTTA
GAACCCACAAGGGGTGAGTGGAAGTTTTGTAGCCCATCAAAGGTGAATATGTGTTCTGCAGTATCAACTAAAACAGTGTACAAAATCATT
AAACTGGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGCCAGGAGTTCAAGA
CCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAGGTGTGGTGTTGCATGCCTGTAATCCCAGCTATTA
GGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGTCGAGATCACACCATTGCACTCCAGCCTGGGCAATA
AGAGCAAAACTCCGTCTCAAAAATAATAATAATAATAATTTAACTGTGTTCTGCACACACAGAATTACAAAATCCCTATAGGACTTTCAC
AGATAGCTTTGGGCTTAAGGTCTTCGGACAACAGGTAGTTCTAATTTCTTACTCTTTGGGACATTTAGTACATGTTGGTACACATAAGGA
AAGAAAATGGCTTATATTAGAGCTAGGAAACAGGGGCAGCCTGGATTTTTATGGTAGGAACTCACTCTGTGCTTTTTTTTTTTTCTGTTA
AGTTTTCTTGACACTGACTTCGGTAACATTGGCTAAAGGGAATTGTGAGTCATGTGAATTTCACCTGCAGTGCAGACTTTAAAGGACTGT
GTTCATTCTGATTTGGGGATGAAGAGAATGTTCCATGCACATCTATTGATTGGTCTTGGCAGTTGCTGATACGCTTGTCTCATTCACACT
CCCAAAGGCGAGGATTTACCCTAGAAATCATAAACCCCCACTTTCCAAAGCAAAGATGCTGTTAATGTTATGATGGTGCATAAATACCTC
AACTGTCTGGGCTGAGAGAGGGGGCTGCAGGTTTTTAAGAGAGCAGCTATAGTCCTCATTCCATGTAGTCACATCATCTGATGACAGGAC
TCCACATTCTAGCTTTTCTCACTGTGGAAAAGAAACGTTACTGTTTAATTAATATCCAAAGTTATAAATACAGCTTGTAAATTTTACTAA
CTTGTTTCTTTTTCGTTTCGTCCTTGAGAAGTACAACTTGCATTTACAGATGGTAATTCCTAGTGTTGTTCTCTGCTATCTTTTTTTGGT
ATGAAATTGCTGTATTTGTTAAAGTTTGTTCGTTTTGTGGTTTTTAATTCCCATTGGTGTGCTGTACAATGTAGTGTATCATGAAGAAAG
AAATAATATGCAGATGTATTATGAAATGTGTTTTATTTTCAAATGTGTGGTGTTGACAATATATTGATTTATCAAGATACTAAGGGAAAA
TTCTAAATTTAACAAAATGTGTATATTTTAATAAATGCATAAAGCTTTATTGTGTGCCTTTAAATTTAAAAATGGGTTTATAAAGAAAGT
CAGAAACAAAAGTGTCTTACTATAAAATATCCATAGTAATGTAAAGCTTTTACACGAGACTACCAAAAAAAAAGAAAGAAAAGAAAAAGG
AGCCTTCCCATATTTTGTTAACCTTAACCAGTATCTGAAGTCTGTTACTTTTTTTCCATTCTTAAATGGAGATGAATAAGTGAATTTCGC
CTTAAGTGTTTCAATTGTCCTTTGTAGAAAAGCCAGATAAATGAGTTCACTTTGAATTGCATTATTGTGGAAAATTCATTTTCAGAATAA

>64752_64752_2_PHC3-SLC7A14_PHC3_chr3_169854207_ENST00000494943_SLC7A14_chr3_170185165_ENST00000231706_length(amino acids)=401AA_BP=294
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQML
IFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKG
ESPSLESRSTAVTRTSSIHQLIAPGLLIYFGYGIWNSTLEISAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPTEDKGFY

--------------------------------------------------------------
>64752_64752_3_PHC3-SLC7A14_PHC3_chr3_169854207_ENST00000495893_SLC7A14_chr3_170185165_ENST00000231706_length(transcript)=8745nt_BP=951nt
GCGCAGCCCATGTTAGTGATGGAGGAGAGAAGATGGCGGAAGCGGAATTTAAGGACCATAGTACAGCTATGGATACTGAACCAAACCCGG
GAACATCTTCTGTGTCAACAACAACCAGCAGTACCACCACCACCACCATCACCACTTCCTCCTCTCGAATGCAGCAGCCACAGATCTCTG
TCTACAGTGGTTCAGACCGACATGCTGTACAGGTAATTCAACAGGCATTGCATCGGCCCCCCAGCTCAGCTGCTCAGTACCTTCAGCAAA
TGTATGCAGCCCAACAACAGCACTTGATGCTGCATACTGCAGCTCTTCAGCAGCAGCATTTAAGCAGCTCCCAGCTTCAGAGCCTTGCTG
CTGTTCAGGCAAGTTTGTCCAGTGGAAGACCATCTACATCTCCCACAGGAAGTGTCACACAGCAGTCAAGTATGTCCCAAACGTCTATCA
ACCTCTCCACTTCTCCTACACCTGCACAGTTAATAAGCCGTTCCCAGGCTTCCAGTTCTACCAGCGGCAGTATTACCCAACAGACTATGT
TACTAGGGAGTACTTCCCCTACCCTAACGGCAAGCCAAGCTCAAATGTATCTCCGAGCTCAAATGCTGATTTTCACACCCGCTACCACTG
TGGCTGCTGTACAGTCTGACATTCCTGTTGTCTCGTCGTCATCGTCATCTTCCTGTCAGTCTGCAGCTACTCAGGTTCAGAATTTAACAT
TACGCAGCCAGAAGTTGGGTGTATTATCTAGCTCACAGAATGGTCCACCAAAAAGCACTAGTCAAACTCAGTCATTGACAATTTGTCATA
ACAAAACAACAGTGACCAGTTCTAAAATCAGCCAACGAGATCCTTCTCCAGAAAGTAATAAGAAAGGAGAGAGCCCAAGCCTGGAATCAC
GAAGCACAGCTGTCACCCGGACATCAAGTATTCACCAGTTAATAGCACCAGGTCTGCTCATTTATTTTGGATATGGCATCTGGAACAGCA
CCCTGGAAATCAGCGCTCGAGAAGAGGCCCTGCACCAAAGCACGTACCAACGCTACGACGTGGATGACCCCTTCTCAGTGGAGGAGGGTT
TCTCCTACGCCACAGAGGGCGAGAGCCAGGAGGACTGGGGCGGGCCCACTGAAGACAAAGGCTTCTATTACCAACAGATGTCAGATGCGA
AGGCAAACGGCCGGACAAGTAGCAAAGCGAAGAGCAAAAGCAAACACAAACAGAACTCAGAGGCCCTGATTGCAAATGATGAGTTAGATT
ACTCTCCAGAGTAGGAGAAACACACAAGTGGGTAGAAATGGTGATGACTGATTTTCAGTAACTTAACCTGTGGGCTAGAAGGTGAAAACT
TTTTTGGCTCTCATTTCACAAATCCAGCCTTCCCCAAATTCAATCCCTAGTCATAGCCTGTCATTTGCTACTTTTGCTCTTCAGGATAGT
TCTGTTGAAGGGCTTAACCTGGGTCCCCTAACTGGTCGCCTTGTTAAATAAAATAAATAAATAAACAAGAGGCTATATGAAATTCCATCT
TAGGTGCAACCACCAGAGCTGATGGTACCAAATGTTTCCTAGGCCTTTGCTTTGCTGGTTGAAGCCCAAGCAGGGGCTCTGGGCAGAAGG
CAGAATTTCAGTCACCTGAGACATGGGGACAAAGCTCTGTTCTTGGCATGTCAGGCTGAGTGCTGCTCCCCGAGGTCAGGGTGGGTAGAT
GGGCATTGGCACTTCCTGAGCAAGCATCATTTTATCCTGCAATCTCACCCAAAATTAATTCATGGAAAAGACACATGCTTCTTTTTATTC
ACCAACATTCTCACAGCTTCCAAACTATAATTTTAGGATCCAGCAAAGTTCAGGGACTCTGGACCATTTTCCCAATGGTTTCAGATTCAC
CATAAAGCAGTCAGGCAGACCCAGTGATATGGTAAGAAGCACCATCAAAGCTCTATGTAAATGCCCAGAAGAAAATTAAATAACCATATC
TTGCGGTAAAAGCCAGAAGGGCATTGGCAGAAATTAACTCTCTGTCATGGCCTCTCTTATATCAGACTGCAGCTCCTGGTGATATGATGA
AAGCGGGCAAAGGTGGAGCATGATTTCATGGCACTGATATGCCTTGAAAAAGTAGGTTGTTTGTTTTATAATCAGATAAAAATTTTTACA
AGGAGAAGTGAGCCAGCCACTGAGATCACATTGCAAATTCTCTTTCATATTTCTAAAATTATAAATTCTAAAGTTTTTGAGATAGGCAAC
CACTTGATTGGTGTGTGCTACTCTGAAAACAAAATAGGCTGAAGTATAGCGACTTAGGTAGTTGCATTCCATGAGATCACATTTCACTTC
TGAACCTTATTCCTTGGGGCTAGCTCACTTTCAGAGGTGTATTTTTTTTTCCTGTTATTTCCCAGAGTAGTTTCACTGAAGCCCAGAGAA
ATATCTACCTGGTAAGATGTAAATTTGGGCCATAAAAGGGGCTATTAAAAGAATTTTCTCAGAAATAGAATAGATGAGAGAATTTGCAAA
GGAAAAAAACACACATGGGCTACAATATAAATTCTACTCTTGGGTTACAAGAATTCCTGTGGCTGCACTGAGATACGTACAAATGTATGT
GAAGGCACAATTTGAATCAAGCTATCATAGAATTAACCAAGCTATTAAAATTAATCAAGCTATTAATAAAATCTCTGTGAGGATTTCCTG
AAAGAGGGACAAAAGAAGAAATTCCTTGTCCTTTCTCTCCTGGATGTATCAGTATGCCAAACGTTTTCCAGAACATATTCGCTAGCACTC
AAGTCTGTTCTTTCTGAAAGGCTGAGGCTCATGCCATCTTGGCATGCTTTAGGATTATGGCAAGGAGGTAAAAGTCCATTTTTTCATTCA
ACTAACACTGGTTGAGAATAGACCCAATGCTAAGTGACAGGAATGAATAGAAGCATGGCACTTGCCCTTGGGGGCTACAGTCCATGGATG
AGCAGCACTGGAGCCTGGTAAATGCAGATAAAACAACAAACTTGACAAGTCTCCAGGCTGATGCACTGGGTTTTAACATACATATAAAGA
TGAATTGAAACTAGTTTTTAAAAAATATGCTTTAAATAAATTACATATCGTAATCATAGCCAATGTATACCATTAAACTAAAATAACTGC
AATTTTCTAGATATTTTTTATTCTTCTGTAGTCATTGTTTAGAACTCTGGTTTCCTGAGGTCATTTTGTCATTTTAATATCATGCTTGAC
AATGCTATGTTTTCTCTTCCCTAGAGTTAACCATAAAGATACAGTGCCTACTCTGTGAAATACAGCATTAGGAATTAATTATAAACTAAT
TATCAGTCATCTTTTGAAAACAAAGTTTTGAATTGGCTATAGGACTCAACAAATCTGCCTGGTGTAAATAGAATCTGTTAAGCTTGATAC
ATATCTAGATAGATGAGGAGGGGTTGTATTCATTAAGCATGAGAATAGAGAAATAGGAGTGCAAAATGGCAAAATCTTAACGTGGGTGAA
AGAGCTTCCTTTTACTAGTGAGGTTTAAGTATTAAAGTAACAATAGCCTGGTGGCAGATGAATGCAATTTCTATAGGATGGGAATGGAAA
ATGTATGCTTTGGTTAACACCATTGCTGTTGACTTCATGCAGATTCTATTAAGCACTCTCATTTCAGGAGCCATTTTTCCCACATAGTAT
ATTAGTATATTTTAAGCTTAGCTCCCTTTATTTTTCTAAAGTTGATAAATCACCTCCCTAGCAACCTTAGTTTTAAAAAAAAAATCACTA
AGATAGAAAAAGTATTTTCAGGTACATAGACATGTTTGTCCTCAGGTTTACCTGCTTCTGTGAACAGTCCCAGATTTTACAATGCAGTTT
TCAAATACCATCAATCACTACAATGACAATATTACTATTTTCTTAACAGGTTTCTAAACGATGTATGTGTGGGATCACATTAAAAGTAAG
ATCACCTTATAATTATCTTAGAAACTTTGCCCCTTGAAGGGAGTCCAAGGAAGACCTACATTTTATTGAATTCTGAATAGCAAAAGCTCT
CCGAGTGAGATTTCATTGTGTGGATTTGTGGTTTGGAGCCAATTACTTGATTTTCTTCAGATTTTATTCTACTTATTTATTGGTACTCTG
CTTCATTTCAAAAGGATTTGAGGCAGCTACTAAAATATATATAATACAAAACAAAAATTAAGTGAGGAACTCAGAGCAAACAAAAATAGA
AACAGAAAGGATAAGACAAAACTAGACGTATATTTAGTACATAAATGCAGAACCCTGACATGCTTTACTAAATTTGCCAATGAGTGACAC
CATGAAAAATAATAGAATTAGTGGTAATGACAAGAAGAAGTACTTCTGCATGATAAGAACAAATCTTTCCCCATGCAGGTAGAGGTTTGA
AATAGCATAGATCATTAAAATCCACAGGTAAGCTTCAAACCTAGATTTTGCTAGCTACATGTGCCTGGCATATAGTGTGTATTCAAGAAA
TACCTGATGATTGACAGAATGAATGAATTGGAGGAAAATGAAATATTTATTCAACAATTACTTGTGGAGTGCCTATTATGTACTATGGCA
GATATTGATATCGTAAGTCAGATAAAAATCCAGCTCTTAAGAAGTAGAGGAAATAGAGCTTGGTGTGGTGGCATGTGCCTATGATCCCAG
ATAGTTGAGAGACTGAGGGAGGAGGATCACTTGAGCCCAGGAGTTCAAGGCTGCAGTGAGCTATGATCACACCACTGTACTCCAGCCTGG
GTAACAGAAGAATACCCTGTCTCTTAAAAAGGAAAATCAAATAGGGGAAATGGGATATATAAATAAAGAACAATAGTGAATGTGTCAGGT
GAGATGACGGACTTGTAATGTGCTGTGGGGGGTCAAATATGAAGAAGGCCTTCTTCCTCTGGAAAGGTCATAAAGAATGTCACACTTGTG
TTGGAACTTGTGAAGTGGGTAGAATTTTATCAAGTAGAAATGAGAGAAAGGCATGCCAAGCAAAGGATCGGCATGAATAAGGTCTACTAG
TTTGTGGTCCTCTGGCTAAGAATTTGTGCTGTGCCTCCATTAAGAGAAAGCAAGGAGCTAGTTTGCCTGGAGCACATGATTTATGCATGA
CTTATACATGCAACAATAAGAAATAATGCTAGGAAGGCAGGTGAGGGATCACTCACAGAGAGACTTGAATGTCACACTGAGCTGACTGGC
TTTCCTCGGGTGAGAGAGTGGGAAATAATTGGGGAACTGACGAAAGTGTGAATCCAGGAAGGCTGAACTTTAAGAAAGCTGAGACGGTGG
CTTCCTTACCTATGCAAGGAACTAACAAGCCACATATACACTCCAAATTGATTTAACAAATTAAAGAGAAAAATAGCTGTACTTTGAGTC
CTGTGTCTGCATTCATCATTAACCTAAGAAAATACAGCCATTTAATACGTGGACAAGCAACACAATTTAACAGCCACTTTAAAGTTTTCA
ACAATAGGTTTCAACAACTAAACCTAACAACTTTTTATATCTATCTAATCTAAACAGTAAAATCTCAGCTCCAGGTTTTACTGAGCTTGA
GTGCTACTTTTTTTTTTTTAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTTCACCT
CCCGGGTTCAAGCTATTCTCCTGCCTCAGCCTCCCAAGCAGCTGGGATTATAGGCGTGTGCCAGTTCTACTTCTTAGTAACAAACTAGTA
GCTAATCAAATGCCTACATAATGGTCATGATAAATCTGTTTAAATAAATGGCGGGCGGAAGGGAGTTGTTGAATTTAACAATCCATCCTT
CTTCAGAATCTATAGGTCAGCCAGAATATAAATCTAGTAATTATTGAAAAACAAAACACAAACTCCTTCAAAGAAATCTCTCTCCTCTAT
TCTGCTGAAAAGGGTTGGTAAACCTGACATCCTTTCTTTTATTGGAAGACAAATCCAACATTTGTTAGACATCCAACATTTGTTGGAAGT
CTACCTTACAAGAAACCACCTCTTATCTGCAACATAAACAGAAGCTACATCAGGTTGAAAATCCACATAGAAGACTGGAGAAAATTGCCG
TCCCCTTTCGCACTAGGTTTTACCAGGGGCCCAAGATGTCAGAGGAAAGTCCGCGGAGGGCCAAACACAGGTTTACCTAATTATGAATCT
CAGATTAGAATGTCTTATTGTGTGGAAAAGTCAGAACTCAGGAAATGTGTCTGAAGCCAGAGCGGGGGTCTGCTTACGGAGTCTACGCAG
CGGGTAGGGGTCCACTATTGGAGTATAAACCTCAGGTCAGTGAGTAGTGCAGAGGTGTCCCTAACTTCCAATGGAGGGAAAGAGAGGAGA
GCAAAGGAAACACATCCAGAAGTCGCCACGAGGGCTGTGTGCCAGCGCTCCATTTTCATGCTGTTTGGAACAAGACGTGTCAAGGAAGAT
GTTTCTATCCAAAGTCTTCATGGAGCCTCTGCTTCCCCTGTACCTGTGTAGCTCCCTGAAACTGAGGACCCACGTGTCTGCAAAGACCTC
TGGAGATCCTAAGAGAGAGAGGCACCAGCAGGTAACCAGTGGTGGCCTGGCCACGAAAGAGTATTTGAAATTCAACAGTGAGCAAGTGCA
GAAACAGCATCCCAAACCGCAGGCCCCACCACACGCAGGAACCAGAAAGCTGAAGTTTCACCAAGGAGTTTACTTAGTATTTCTCGCTGG
GAATGGGGATGGGTAGCAAAAAGCCCCTTTCATGTACATAATGGTTGGTCCTATGTCCTACTTTTATTTTCTCTAAGAGTTTTAGAAGAA
AGGCTGTTTTAATTTTTTTTTCTCCTTAAGAGCAACTTCCTTTTTAAAATGCTTTCCTCTTCTTGTCCTGCTTGAGTAATGCAGGCATCA
TTCTGAAATCATTCTGAAACAGCTAGGCAGTCGCCTTTTGCCAAAATTACTTCTCTAAGAAAATAGAGTGTTCTTTTTTTTAGGACTTAG
AACCCACAAGGGGTGAGTGGAAGTTTTGTAGCCCATCAAAGGTGAATATGTGTTCTGCAGTATCAACTAAAACAGTGTACAAAATCATTA
AACTGGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGCCAGGAGTTCAAGAC
CAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAGGTGTGGTGTTGCATGCCTGTAATCCCAGCTATTAG
GGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGTCGAGATCACACCATTGCACTCCAGCCTGGGCAATAA
GAGCAAAACTCCGTCTCAAAAATAATAATAATAATAATTTAACTGTGTTCTGCACACACAGAATTACAAAATCCCTATAGGACTTTCACA
GATAGCTTTGGGCTTAAGGTCTTCGGACAACAGGTAGTTCTAATTTCTTACTCTTTGGGACATTTAGTACATGTTGGTACACATAAGGAA
AGAAAATGGCTTATATTAGAGCTAGGAAACAGGGGCAGCCTGGATTTTTATGGTAGGAACTCACTCTGTGCTTTTTTTTTTTTCTGTTAA
GTTTTCTTGACACTGACTTCGGTAACATTGGCTAAAGGGAATTGTGAGTCATGTGAATTTCACCTGCAGTGCAGACTTTAAAGGACTGTG
TTCATTCTGATTTGGGGATGAAGAGAATGTTCCATGCACATCTATTGATTGGTCTTGGCAGTTGCTGATACGCTTGTCTCATTCACACTC
CCAAAGGCGAGGATTTACCCTAGAAATCATAAACCCCCACTTTCCAAAGCAAAGATGCTGTTAATGTTATGATGGTGCATAAATACCTCA
ACTGTCTGGGCTGAGAGAGGGGGCTGCAGGTTTTTAAGAGAGCAGCTATAGTCCTCATTCCATGTAGTCACATCATCTGATGACAGGACT
CCACATTCTAGCTTTTCTCACTGTGGAAAAGAAACGTTACTGTTTAATTAATATCCAAAGTTATAAATACAGCTTGTAAATTTTACTAAC
TTGTTTCTTTTTCGTTTCGTCCTTGAGAAGTACAACTTGCATTTACAGATGGTAATTCCTAGTGTTGTTCTCTGCTATCTTTTTTTGGTA
TGAAATTGCTGTATTTGTTAAAGTTTGTTCGTTTTGTGGTTTTTAATTCCCATTGGTGTGCTGTACAATGTAGTGTATCATGAAGAAAGA
AATAATATGCAGATGTATTATGAAATGTGTTTTATTTTCAAATGTGTGGTGTTGACAATATATTGATTTATCAAGATACTAAGGGAAAAT
TCTAAATTTAACAAAATGTGTATATTTTAATAAATGCATAAAGCTTTATTGTGTGCCTTTAAATTTAAAAATGGGTTTATAAAGAAAGTC
AGAAACAAAAGTGTCTTACTATAAAATATCCATAGTAATGTAAAGCTTTTACACGAGACTACCAAAAAAAAAGAAAGAAAAGAAAAAGGA
GCCTTCCCATATTTTGTTAACCTTAACCAGTATCTGAAGTCTGTTACTTTTTTTCCATTCTTAAATGGAGATGAATAAGTGAATTTCGCC
TTAAGTGTTTCAATTGTCCTTTGTAGAAAAGCCAGATAAATGAGTTCACTTTGAATTGCATTATTGTGGAAAATTCATTTTCAGAATAAA

>64752_64752_3_PHC3-SLC7A14_PHC3_chr3_169854207_ENST00000495893_SLC7A14_chr3_170185165_ENST00000231706_length(amino acids)=413AA_BP=306
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTA
SQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKIS
QRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPGLLIYFGYGIWNSTLEISAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PHC3-SLC7A14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PHC3-SLC7A14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PHC3-SLC7A14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source