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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHEX-ADCY8 (FusionGDB2 ID:64755)

Fusion Gene Summary for PHEX-ADCY8

check button Fusion gene summary
Fusion gene informationFusion gene name: PHEX-ADCY8
Fusion gene ID: 64755
HgeneTgene
Gene symbol

PHEX

ADCY8

Gene ID

5251

114

Gene namephosphate regulating endopeptidase homolog X-linkedadenylate cyclase 8
SynonymsHPDR|HPDR1|HYP|HYP1|LXHR|PEX|XLHAC8|ADCY3|HBAC1
Cytomap

Xp22.11

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionphosphate-regulating neutral endopeptidase PHEXX-linked hypophosphatemia proteinmetalloendopeptidase homolog PEXphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)phosphate-readenylate cyclase type 8ATP pyrophosphate-lyase 8HEL-S-172mPadenylate cyclase 8 (brain)adenylate cyclase type VIIIadenylyl cyclase 8adenylyl cyclase-8, brainca(2+)/calmodulin-activated adenylyl cyclaseepididymis secretory sperm binding protein Li
Modification date2020032220200313
UniProtAcc.

P40145

Ensembl transtripts involved in fusion geneENST00000379374, ENST00000418858, 
ENST00000535894, ENST00000537599, 
ENST00000475778, 		ENST00000286355, 
ENST00000377928, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PHEX [Title/Abstract] AND ADCY8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHEX(22186506)-ADCY8(132002788), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHEX

GO:0006508

proteolysis

11409890


check buttonFusion gene breakpoints across PHEX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADCY8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-27-1830-01APHEXchrX

22186506

+ADCY8chr8

132002788

-


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Fusion Gene ORF analysis for PHEX-ADCY8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000379374ENST00000286355PHEXchrX

22186506

+ADCY8chr8

132002788

-
In-frameENST00000379374ENST00000377928PHEXchrX

22186506

+ADCY8chr8

132002788

-
In-frameENST00000418858ENST00000286355PHEXchrX

22186506

+ADCY8chr8

132002788

-
In-frameENST00000418858ENST00000377928PHEXchrX

22186506

+ADCY8chr8

132002788

-
In-frameENST00000535894ENST00000286355PHEXchrX

22186506

+ADCY8chr8

132002788

-
In-frameENST00000535894ENST00000377928PHEXchrX

22186506

+ADCY8chr8

132002788

-
In-frameENST00000537599ENST00000286355PHEXchrX

22186506

+ADCY8chr8

132002788

-
In-frameENST00000537599ENST00000377928PHEXchrX

22186506

+ADCY8chr8

132002788

-
intron-3CDSENST00000475778ENST00000286355PHEXchrX

22186506

+ADCY8chr8

132002788

-
intron-3CDSENST00000475778ENST00000377928PHEXchrX

22186506

+ADCY8chr8

132002788

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379374PHEXchrX22186506+ENST00000286355ADCY8chr8132002788-4932204756248421426
ENST00000379374PHEXchrX22186506+ENST00000377928ADCY8chr8132002788-4450204756244491296
ENST00000537599PHEXchrX22186506+ENST00000286355ADCY8chr8132002788-4475159010543851426
ENST00000537599PHEXchrX22186506+ENST00000377928ADCY8chr8132002788-3993159010539921295
ENST00000535894PHEXchrX22186506+ENST00000286355ADCY8chr8132002788-4665178037645751399
ENST00000535894PHEXchrX22186506+ENST00000377928ADCY8chr8132002788-4183178037641821269
ENST00000418858PHEXchrX22186506+ENST00000286355ADCY8chr8132002788-376688129036761128
ENST00000418858PHEXchrX22186506+ENST00000377928ADCY8chr8132002788-32848812903283998

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379374ENST00000286355PHEXchrX22186506+ADCY8chr8132002788-0.0012204540.9987796
ENST00000379374ENST00000377928PHEXchrX22186506+ADCY8chr8132002788-0.0010296360.9989704
ENST00000537599ENST00000286355PHEXchrX22186506+ADCY8chr8132002788-0.000900850.99909914
ENST00000537599ENST00000377928PHEXchrX22186506+ADCY8chr8132002788-0.0007890790.99921095
ENST00000535894ENST00000286355PHEXchrX22186506+ADCY8chr8132002788-0.0014625730.9985374
ENST00000535894ENST00000377928PHEXchrX22186506+ADCY8chr8132002788-0.0012900630.9987099
ENST00000418858ENST00000286355PHEXchrX22186506+ADCY8chr8132002788-0.0009499170.9990501
ENST00000418858ENST00000377928PHEXchrX22186506+ADCY8chr8132002788-0.0008869610.999113

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Fusion Genomic Features for PHEX-ADCY8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHEX-ADCY8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:22186506/chr8:132002788)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADCY8

P40145

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. {ECO:0000250|UniProtKB:P40146}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHEXchrX:22186506chr8:132002788ENST00000379374+13221_20494750.0Topological domainCytoplasmic
HgenePHEXchrX:22186506chr8:132002788ENST00000379374+132221_41494750.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneADCY8chrX:22186506chr8:132002788ENST000002863550181109_11113201252.0Nucleotide bindingATP
TgeneADCY8chrX:22186506chr8:132002788ENST000002863550181116_11203201252.0Nucleotide bindingATP
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018419_4243201252.0Nucleotide bindingATP
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018461_4633201252.0Nucleotide bindingATP
TgeneADCY8chrX:22186506chr8:132002788ENST000002863550181200_12153201252.0RegionRequired for both calcium stimulation and maintenance of autoinhibition
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018342_7153201252.0Topological domainCytoplasmic
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018915_12513201252.0Topological domainCytoplasmic
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018321_3413201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018716_7363201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018738_7583201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018787_8073201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018831_8513201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018861_8813201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018894_9143201252.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHEXchrX:22186506chr8:132002788ENST00000379374+132253_749494750.0DomainPeptidase M13
HgenePHEXchrX:22186506chr8:132002788ENST00000379374+132242_641494750.0Topological domainExtracellular
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018183_2033201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018212_2323201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018247_2673201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018274_2943201252.0TransmembraneHelical
TgeneADCY8chrX:22186506chr8:132002788ENST00000286355018296_3163201252.0TransmembraneHelical


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Fusion Gene Sequence for PHEX-ADCY8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64755_64755_1_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000379374_ADCY8_chr8_132002788_ENST00000286355_length(transcript)=4932nt_BP=2047nt
AAGGGACTCACACACTGAAAGAATATCTTTGATGAAGACAATTCAGGCAAGCAGAATGATTCTTGCAACAGAATTACATGATTAATTGAG
ATCTTGAAGTGGGTCCGGTGAATCCTGGCCACCTAACTTATCATGATTTGGGGGAGTTTCACGAGAATCCAGTTTTGATAAAACAATTGT
TTTTTTCCTCCCCAAGTGACTATACATTTAAATAGCTAAAACATCTGTTCAGCAACATAGTAAAACATATATACTCGGAACGCTTGAGAG
AAGAGCCTGCCAAACAGGGACTTTGCTGAGGGAGAGCACCAAGATAAAGCAACACTGTTTGTTTTGTCTAGTCAGGGGGAAAGCCAAGGC
AACCAATATTTTGGTTTTTATAATTTTCATTTGTGAAGAATTATTTGAGAAAGGGTGGCGAGGGGAGATTTCCTGACGGCAGTTTCTTAA
GCTGTCCATTAGTAGAAGAGCAAGAAAGCCTTGGATGTCAACGCCTCGCTCTTGAGACCAGCCACCAAACCACGAAAAGTGACTTTCTTC
TCGTGTGCTCTCTACGGCCCTTCTGATGGAAGCAGAAACAGGGAGCAGCGTGGAGACTGGAAAGAAGGCCAACAGAGGCACTCGAATTGC
CCTGGTCGTGTTTGTCGGTGGCACCCTAGTTCTGGGCACGATCCTCTTTCTAGTGAGTCAAGGTCTCTTAAGTCTCCAAGCTAAACAGGA
GTACTGCCTGAAGCCAGAATGCATCGAAGCGGCTGCTGCCATCTTAAGTAAAGTAAATCTGTCTGTGGATCCTTGTGATAATTTCTTCCG
GTTCGCTTGTGATGGCTGGATAAGCAATAATCCAATTCCCGAAGATATGCCAAGCTATGGGGTTTATCCTTGGCTGAGACATAATGTTGA
CCTCAAGTTGAAGGAACTTTTGGAGAAATCAATCAGTAGAAGGCGGGACACCGAAGCCATACAGAAAGCCAAAATCCTTTATTCATCCTG
CATGAATGAGAAAGCGATTGAAAAAGCAGATGCCAAGCCACTGCTACACATCCTACGGCATTCACCTTTCCGCTGGCCCGTGCTTGAATC
TAATATTGGCCCTGAAGGGGTTTGGTCAGAGAGAAAGTTCAGCCTTCTGCAGACACTTGCAACGTTTCGTGGTCAATACAGCAATTCTGT
GTTCATCCGTTTGTATGTGTCCCCTGATGACAAAGCATCCAATGAACATATCTTGAAGCTGGACCAAGCAACACTCTCCCTGGCCGTGAG
GGAAGACTACCTTGATAACAGTACAGAAGCCAAGTCTTATCGGGATGCCCTTTACAAGTTCATGGTGGATACTGCCGTGCTTTTAGGAGC
TAACAGTTCCAGAGCAGAGCATGACATGAAGTCAGTGCTCAGATTGGAAATTAAGATAGCTGAGATAATGATTCCACATGAAAACCGAAC
CAGCGAGGCCATGTACAACAAAATGAACATTTCTGAACTGAGTGCTATGATTCCCCAGTTCGACTGGCTGGGCTACATCAAGAAGGTCAT
TGACACCAGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTGGTCCGCGTCCCGCAGTACTTTAAAGATTTGTTTAG
GATATTAGGGTCTGAGAGAAAGAAGACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGGCGCTT
TCAGTATAGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTGCCTCAATGGGACAAATGTGTAAACTTTATTGAAAG
TGCCCTCCCTTATGTTGTTGGAAAGATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAGGGCGT
TCGCTGGGCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGAACGAAAAGGAAAGCCAAAGAAAAGGCGAGAGCTGT
TTTGGCAAAAGTTGGCTATCCAGAGTTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTGTTGTGGCCCAGGCAGTGCTATT
CATGTGTATGAACACAGCTGGAATCTTCATCAGTTACCTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTGTGGA
GGCCAGGCTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGGTTTGTTGTCCTGGAAATGATCAA
CGACATGACCAATGTGGAAGATGAGCACCTGCAGCACCAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTTTGC
AGATGTTAAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAGCTCTTTGCCAGATTTGATCG
ACTGGCCCATGAGCATCACTGCCTTCGTATTAAAATCCTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGGACCA
TGCCCACTGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACAAAACACGATGTTGACATGAGGAT
TGGAATCCACTCCGGCTCGGTGCTGTGCGGTGTTTTGGGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTGCAAA
CAAACTCGAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAACGGTGACTATAACGTGGAAGAGGG
CCATGGTAAAGAGAGGAATGAATTCCTGAGGAAGCATAATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCTTGCC
TGAAGATATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAAGGATCCTGGAGCCCTGAACTGCC
CTTTGATAATATCGTGGGGAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAGCTTT
GCATGTCCAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGCGATAAATTGAGAAGAGAGCATAT
CAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCACAAGTATTCTCAAATGAGGGATGAAGTGTTCAAGTCAAACTTGGTCTG
TGCATTTATCGTTCTTCTATTTATCACGGCAATACAAAGTTTGCTTCCTTCTTCAAGAGTGATGCCAATGACCATCCAGTTCTCCATTCT
GATTATGCTGCACTCGGCTCTGGTCCTCATCACCACAGCAGAGGATTATAAATGTTTGCCCCTCATCCTCCGGAAAACTTGCTGTTGGAT
TAATGAGACCTATTTGGCCCGGAACGTCATCATCTTTGCATCCATTTTGATTAATTTCCTGGGTGCCATCTTAAATATCCTGTGGTGTGA
TTTTGACAAGTCGATACCCTTGAAGAACCTGACTTTCAATTCCTCAGCTGTGTTTACAGATATCTGCTCCTACCCAGAGTACTTTGTCTT
CACGGGGGTGTTGGCCATGGTGACCTGTGCAGTTTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCAGTGCTGCTGATCATGATTGCCAT
CTATGCCCTGCTCACTGAGACCGTCTACGCAGGCCTCTTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGACCAA
GGAGGTATCACTGCTACTGATGGCCATGTTCCTCCTGGCTGTGTTCTACCATGGACAGCAGCTGGAGTACACAGCCCGCCTGGACTTCCT
TTGGCGAGTACAGGCCAAAGAGGAGATCAATGAGATGAAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAGCCA
TGTGGCCCGCCATTTCCTAGAGAAGGACCGAGACAATGAGGAGCTGTATTCTCAATCCTATGATGCTGTTGGGGTGATGTTTGCCTCCAT
CCCAGGATTTGCGGACTTTTACTCTCAGACTGAAATGAATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGACTT
CGATGAGTTGCTTGGTGAAGACCGATTTCAAGACATTGAAAAGATTAAGACCATTGGCAGCACCTACATGGCCGTGTCAGGCCTGTCACC
TGAAAAACAGCAATGTGAAGACAAGTGGGGACATTTGTGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGATCAA
CAAGCATTCATTCAACAATTTTGAACTCCGGATTGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTTATCGGCGCTAAGAAACCACAGTA
TGACATTTGGGGCAAAACTGTGAACCTGGCAAGCCGAATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTATCT
CATCCTGAAGGACCAGGGCTTTGCCTTTGATTACCGAGGGGAGATCTATGTGAAGGGTATCAGTGAACAGGAAGGAAAAATCAAAACGTA
CTTTCTTCTGGGAAGAGTCCAACCCAACCCATTCATCTTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCTGGG
ACTTGTCCAGTCCCTCAATAGGCAAAGGCAGAAGCAGCTACTCAATGAGAACAACAACACAGGAATCATCAAGGGTCATTACAACCGGCG
GACTTTGTTGTCACCCAGCGGCACAGAGCCTGGAGCCCAGGCTGAAGGCACCGACAAATCTGATTTGCCATAAAAGCATTTTCTTTCTGT

>64755_64755_1_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000379374_ADCY8_chr8_132002788_ENST00000286355_length(amino acids)=1426AA_BP=495
MMEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI
SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGV
WSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEH
DMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERK
KTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDM
LEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLET
ENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHC
LRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGI
PGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGK
QNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLF
ITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPL
KNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLM
AMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFY
SQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNF
ELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQ

--------------------------------------------------------------
>64755_64755_2_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000379374_ADCY8_chr8_132002788_ENST00000377928_length(transcript)=4450nt_BP=2047nt
AAGGGACTCACACACTGAAAGAATATCTTTGATGAAGACAATTCAGGCAAGCAGAATGATTCTTGCAACAGAATTACATGATTAATTGAG
ATCTTGAAGTGGGTCCGGTGAATCCTGGCCACCTAACTTATCATGATTTGGGGGAGTTTCACGAGAATCCAGTTTTGATAAAACAATTGT
TTTTTTCCTCCCCAAGTGACTATACATTTAAATAGCTAAAACATCTGTTCAGCAACATAGTAAAACATATATACTCGGAACGCTTGAGAG
AAGAGCCTGCCAAACAGGGACTTTGCTGAGGGAGAGCACCAAGATAAAGCAACACTGTTTGTTTTGTCTAGTCAGGGGGAAAGCCAAGGC
AACCAATATTTTGGTTTTTATAATTTTCATTTGTGAAGAATTATTTGAGAAAGGGTGGCGAGGGGAGATTTCCTGACGGCAGTTTCTTAA
GCTGTCCATTAGTAGAAGAGCAAGAAAGCCTTGGATGTCAACGCCTCGCTCTTGAGACCAGCCACCAAACCACGAAAAGTGACTTTCTTC
TCGTGTGCTCTCTACGGCCCTTCTGATGGAAGCAGAAACAGGGAGCAGCGTGGAGACTGGAAAGAAGGCCAACAGAGGCACTCGAATTGC
CCTGGTCGTGTTTGTCGGTGGCACCCTAGTTCTGGGCACGATCCTCTTTCTAGTGAGTCAAGGTCTCTTAAGTCTCCAAGCTAAACAGGA
GTACTGCCTGAAGCCAGAATGCATCGAAGCGGCTGCTGCCATCTTAAGTAAAGTAAATCTGTCTGTGGATCCTTGTGATAATTTCTTCCG
GTTCGCTTGTGATGGCTGGATAAGCAATAATCCAATTCCCGAAGATATGCCAAGCTATGGGGTTTATCCTTGGCTGAGACATAATGTTGA
CCTCAAGTTGAAGGAACTTTTGGAGAAATCAATCAGTAGAAGGCGGGACACCGAAGCCATACAGAAAGCCAAAATCCTTTATTCATCCTG
CATGAATGAGAAAGCGATTGAAAAAGCAGATGCCAAGCCACTGCTACACATCCTACGGCATTCACCTTTCCGCTGGCCCGTGCTTGAATC
TAATATTGGCCCTGAAGGGGTTTGGTCAGAGAGAAAGTTCAGCCTTCTGCAGACACTTGCAACGTTTCGTGGTCAATACAGCAATTCTGT
GTTCATCCGTTTGTATGTGTCCCCTGATGACAAAGCATCCAATGAACATATCTTGAAGCTGGACCAAGCAACACTCTCCCTGGCCGTGAG
GGAAGACTACCTTGATAACAGTACAGAAGCCAAGTCTTATCGGGATGCCCTTTACAAGTTCATGGTGGATACTGCCGTGCTTTTAGGAGC
TAACAGTTCCAGAGCAGAGCATGACATGAAGTCAGTGCTCAGATTGGAAATTAAGATAGCTGAGATAATGATTCCACATGAAAACCGAAC
CAGCGAGGCCATGTACAACAAAATGAACATTTCTGAACTGAGTGCTATGATTCCCCAGTTCGACTGGCTGGGCTACATCAAGAAGGTCAT
TGACACCAGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTGGTCCGCGTCCCGCAGTACTTTAAAGATTTGTTTAG
GATATTAGGGTCTGAGAGAAAGAAGACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGGCGCTT
TCAGTATAGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTGCCTCAATGGGACAAATGTGTAAACTTTATTGAAAG
TGCCCTCCCTTATGTTGTTGGAAAGATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAGGGCGT
TCGCTGGGCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGAACGAAAAGGAAAGCCAAAGAAAAGGCGAGAGCTGT
TTTGGCAAAAGTTGGCTATCCAGAGTTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTGTTGTGGCCCAGGCAGTGCTATT
CATGTGTATGAACACAGCTGGAATCTTCATCAGTTACCTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTGTGGA
GGCCAGGCTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGGTTTGTTGTCCTGGAAATGATCAA
CGACATGACCAATGTGGAAGATGAGCACCTGCAGCACCAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTTTGC
AGATGTTAAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAGCTCTTTGCCAGATTTGATCG
ACTGGCCCATGAGCATCACTGCCTTCGTATTAAAATCCTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGGACCA
TGCCCACTGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACAAAACACGATGTTGACATGAGGAT
TGGAATCCACTCCGGCTCGGTGCTGTGCGGTGTTTTGGGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTGCAAA
CAAACTCGAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAACGGTGACTATAACGTGGAAGAGGG
CCATGGTAAAGAGAGGAATGAATTCCTGAGGAAGCATAATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCTTGCC
TGAAGATATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAAGGATCCTGGAGCCCTGAACTGCC
CTTTGATAATATCGTGGGGAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAGCTTT
GCATGTCCAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGCGATAAATTGAGAAGAGAGCATAT
CAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCACAAGTACTTTGTCTTCACGGGGGTGTTGGCCATGGTGACCTGTGCAGT
TTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCAGTGCTGCTGATCATGATTGCCATCTATGCCCTGCTCACTGAGACCGTCTACGCAGG
CCTCTTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGACCAAGGAGGTATCACTGCTACTGATGGCCATGTTCCT
CCTGGCTGTGTTCTACCATGGACAGCAGCTGGAGTACACAGCCCGCCTGGACTTCCTTTGGCGAGTACAGGCCAAAGAGGAGATCAATGA
GATGAAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAGCCATGTGGCCCGCCATTTCCTAGAGAAGGACCGAGA
CAATGAGGAGCTGTATTCTCAATCCTATGATGCTGTTGGGGTGATGTTTGCCTCCATCCCAGGATTTGCGGACTTTTACTCTCAGACTGA
AATGAATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGACTTCGATGAGTTGCTTGGTGAAGACCGATTTCAAGA
CATTGAAAAGATTAAGACCATTGGCAGCACCTACATGGCCGTGTCAGGCCTGTCACCTGAAAAACAGCAATGTGAAGACAAGTGGGGACA
TTTGTGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGATCAACAAGCATTCATTCAACAATTTTGAACTCCGGAT
TGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTTATCGGCGCTAAGAAACCACAGTATGACATTTGGGGCAAAACTGTGAACCTGGCAAG
CCGAATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTATCTCATCCTGAAGGACCAGGGCTTTGCCTTTGATTA
CCGAGGGGAGATCTATGTGAAGGGTATCAGTGAACAGGAAGGAAAAATCAAAACGTACTTTCTTCTGGGAAGAGTCCAACCCAACCCATT
CATCTTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCTGGGACTTGTCCAGTCCCTCAATAGGCAAAGGCAGAA
GCAGCTACTCAATGAGAACAACAACACAGGAATCATCAAGGGTCATTACAACCGGCGGACTTTGTTGTCACCCAGCGGCACAGAGCCTGG

>64755_64755_2_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000379374_ADCY8_chr8_132002788_ENST00000377928_length(amino acids)=1296AA_BP=495
MMEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI
SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGV
WSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEH
DMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERK
KTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDM
LEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLET
ENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHC
LRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGI
PGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGK
QNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYFVFTGVLAMVTCAVFLRLNSV
LKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREH
NENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTI
GSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGV
SGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENN

--------------------------------------------------------------
>64755_64755_3_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000418858_ADCY8_chr8_132002788_ENST00000286355_length(transcript)=3766nt_BP=881nt
ACCATATGGTGTTTTAGGTAGGATAGGGATGCTCTGAAGAATGGAGGCATGTTACTTTCTGTGTTTTTATTTGTTTTTTTTTGAGACACA
GTCTTGCTGTGTCATCCAGGCTGGGGTGCAGTGGTGTGATCTTGGCTCATTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCT
TAGCCTCTCGAGTAGCTGGGATTACAGGTGCCGGCCACCACACCTAGCTAATTTTTGTATTTTTGATAGAGATGGGATTGGCCAGGCTGG
TCTCAAACTCCTGACCTCAAATGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGTTCGACTGGCTGGGCTACATCAAGAAGG
TCATTGACACCAGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTGGTCCGCGTCCCGCAGTACTTTAAAGATTTGT
TTAGGATATTAGGGTCTGAGAGAAAGAAGACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGGC
GCTTTCAGTATAGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTGCCTCAATGGGACAAATGTGTAAACTTTATTG
AAAGTGCCCTCCCTTATGTTGTTGGAAAGATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAGG
GCGTTCGCTGGGCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGAACGAAAAGGAAAGCCAAAGAAAAGGCGAGAG
CTGTTTTGGCAAAAGTTGGCTATCCAGAGTTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTGTTGTGGCCCAGGCAGTGC
TATTCATGTGTATGAACACAGCTGGAATCTTCATCAGTTACCTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTG
TGGAGGCCAGGCTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGGTTTGTTGTCCTGGAAATGA
TCAACGACATGACCAATGTGGAAGATGAGCACCTGCAGCACCAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTT
TTGCAGATGTTAAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAGCTCTTTGCCAGATTTG
ATCGACTGGCCCATGAGCATCACTGCCTTCGTATTAAAATCCTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGG
ACCATGCCCACTGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACAAAACACGATGTTGACATGA
GGATTGGAATCCACTCCGGCTCGGTGCTGTGCGGTGTTTTGGGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTG
CAAACAAACTCGAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAACGGTGACTATAACGTGGAAG
AGGGCCATGGTAAAGAGAGGAATGAATTCCTGAGGAAGCATAATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCT
TGCCTGAAGATATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAAGGATCCTGGAGCCCTGAAC
TGCCCTTTGATAATATCGTGGGGAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAG
CTTTGCATGTCCAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGCGATAAATTGAGAAGAGAGC
ATATCAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCACAAGTATTCTCAAATGAGGGATGAAGTGTTCAAGTCAAACTTGG
TCTGTGCATTTATCGTTCTTCTATTTATCACGGCAATACAAAGTTTGCTTCCTTCTTCAAGAGTGATGCCAATGACCATCCAGTTCTCCA
TTCTGATTATGCTGCACTCGGCTCTGGTCCTCATCACCACAGCAGAGGATTATAAATGTTTGCCCCTCATCCTCCGGAAAACTTGCTGTT
GGATTAATGAGACCTATTTGGCCCGGAACGTCATCATCTTTGCATCCATTTTGATTAATTTCCTGGGTGCCATCTTAAATATCCTGTGGT
GTGATTTTGACAAGTCGATACCCTTGAAGAACCTGACTTTCAATTCCTCAGCTGTGTTTACAGATATCTGCTCCTACCCAGAGTACTTTG
TCTTCACGGGGGTGTTGGCCATGGTGACCTGTGCAGTTTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCAGTGCTGCTGATCATGATTG
CCATCTATGCCCTGCTCACTGAGACCGTCTACGCAGGCCTCTTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGA
CCAAGGAGGTATCACTGCTACTGATGGCCATGTTCCTCCTGGCTGTGTTCTACCATGGACAGCAGCTGGAGTACACAGCCCGCCTGGACT
TCCTTTGGCGAGTACAGGCCAAAGAGGAGATCAATGAGATGAAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCA
GCCATGTGGCCCGCCATTTCCTAGAGAAGGACCGAGACAATGAGGAGCTGTATTCTCAATCCTATGATGCTGTTGGGGTGATGTTTGCCT
CCATCCCAGGATTTGCGGACTTTTACTCTCAGACTGAAATGAATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTG
ACTTCGATGAGTTGCTTGGTGAAGACCGATTTCAAGACATTGAAAAGATTAAGACCATTGGCAGCACCTACATGGCCGTGTCAGGCCTGT
CACCTGAAAAACAGCAATGTGAAGACAAGTGGGGACATTTGTGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGA
TCAACAAGCATTCATTCAACAATTTTGAACTCCGGATTGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTTATCGGCGCTAAGAAACCAC
AGTATGACATTTGGGGCAAAACTGTGAACCTGGCAAGCCGAATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCT
ATCTCATCCTGAAGGACCAGGGCTTTGCCTTTGATTACCGAGGGGAGATCTATGTGAAGGGTATCAGTGAACAGGAAGGAAAAATCAAAA
CGTACTTTCTTCTGGGAAGAGTCCAACCCAACCCATTCATCTTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCC
TGGGACTTGTCCAGTCCCTCAATAGGCAAAGGCAGAAGCAGCTACTCAATGAGAACAACAACACAGGAATCATCAAGGGTCATTACAACC
GGCGGACTTTGTTGTCACCCAGCGGCACAGAGCCTGGAGCCCAGGCTGAAGGCACCGACAAATCTGATTTGCCATAAAAGCATTTTCTTT

>64755_64755_3_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000418858_ADCY8_chr8_132002788_ENST00000286355_length(amino acids)=1128AA_BP=197
MIHLPRPPKVLGLQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWL
EFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVG
YPEFIMNDTHVNEDLKAVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNV
EDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCV
EMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKER
NEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSG
PEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHS
ALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLA
MVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQA
KEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLG
EDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGK
TVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSL

--------------------------------------------------------------
>64755_64755_4_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000418858_ADCY8_chr8_132002788_ENST00000377928_length(transcript)=3284nt_BP=881nt
ACCATATGGTGTTTTAGGTAGGATAGGGATGCTCTGAAGAATGGAGGCATGTTACTTTCTGTGTTTTTATTTGTTTTTTTTTGAGACACA
GTCTTGCTGTGTCATCCAGGCTGGGGTGCAGTGGTGTGATCTTGGCTCATTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCT
TAGCCTCTCGAGTAGCTGGGATTACAGGTGCCGGCCACCACACCTAGCTAATTTTTGTATTTTTGATAGAGATGGGATTGGCCAGGCTGG
TCTCAAACTCCTGACCTCAAATGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGTTCGACTGGCTGGGCTACATCAAGAAGG
TCATTGACACCAGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTGGTCCGCGTCCCGCAGTACTTTAAAGATTTGT
TTAGGATATTAGGGTCTGAGAGAAAGAAGACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGGC
GCTTTCAGTATAGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTGCCTCAATGGGACAAATGTGTAAACTTTATTG
AAAGTGCCCTCCCTTATGTTGTTGGAAAGATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAGG
GCGTTCGCTGGGCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGAACGAAAAGGAAAGCCAAAGAAAAGGCGAGAG
CTGTTTTGGCAAAAGTTGGCTATCCAGAGTTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTGTTGTGGCCCAGGCAGTGC
TATTCATGTGTATGAACACAGCTGGAATCTTCATCAGTTACCTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTG
TGGAGGCCAGGCTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGGTTTGTTGTCCTGGAAATGA
TCAACGACATGACCAATGTGGAAGATGAGCACCTGCAGCACCAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTT
TTGCAGATGTTAAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAGCTCTTTGCCAGATTTG
ATCGACTGGCCCATGAGCATCACTGCCTTCGTATTAAAATCCTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGG
ACCATGCCCACTGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACAAAACACGATGTTGACATGA
GGATTGGAATCCACTCCGGCTCGGTGCTGTGCGGTGTTTTGGGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTG
CAAACAAACTCGAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAACGGTGACTATAACGTGGAAG
AGGGCCATGGTAAAGAGAGGAATGAATTCCTGAGGAAGCATAATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCT
TGCCTGAAGATATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAAGGATCCTGGAGCCCTGAAC
TGCCCTTTGATAATATCGTGGGGAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAG
CTTTGCATGTCCAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGCGATAAATTGAGAAGAGAGC
ATATCAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCACAAGTACTTTGTCTTCACGGGGGTGTTGGCCATGGTGACCTGTG
CAGTTTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCAGTGCTGCTGATCATGATTGCCATCTATGCCCTGCTCACTGAGACCGTCTACG
CAGGCCTCTTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGACCAAGGAGGTATCACTGCTACTGATGGCCATGT
TCCTCCTGGCTGTGTTCTACCATGGACAGCAGCTGGAGTACACAGCCCGCCTGGACTTCCTTTGGCGAGTACAGGCCAAAGAGGAGATCA
ATGAGATGAAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAGCCATGTGGCCCGCCATTTCCTAGAGAAGGACC
GAGACAATGAGGAGCTGTATTCTCAATCCTATGATGCTGTTGGGGTGATGTTTGCCTCCATCCCAGGATTTGCGGACTTTTACTCTCAGA
CTGAAATGAATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGACTTCGATGAGTTGCTTGGTGAAGACCGATTTC
AAGACATTGAAAAGATTAAGACCATTGGCAGCACCTACATGGCCGTGTCAGGCCTGTCACCTGAAAAACAGCAATGTGAAGACAAGTGGG
GACATTTGTGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGATCAACAAGCATTCATTCAACAATTTTGAACTCC
GGATTGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTTATCGGCGCTAAGAAACCACAGTATGACATTTGGGGCAAAACTGTGAACCTGG
CAAGCCGAATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTATCTCATCCTGAAGGACCAGGGCTTTGCCTTTG
ATTACCGAGGGGAGATCTATGTGAAGGGTATCAGTGAACAGGAAGGAAAAATCAAAACGTACTTTCTTCTGGGAAGAGTCCAACCCAACC
CATTCATCTTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCTGGGACTTGTCCAGTCCCTCAATAGGCAAAGGC
AGAAGCAGCTACTCAATGAGAACAACAACACAGGAATCATCAAGGGTCATTACAACCGGCGGACTTTGTTGTCACCCAGCGGCACAGAGC

>64755_64755_4_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000418858_ADCY8_chr8_132002788_ENST00000377928_length(amino acids)=998AA_BP=197
MIHLPRPPKVLGLQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWL
EFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVG
YPEFIMNDTHVNEDLKAVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNV
EDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCV
EMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKER
NEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSG
PEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRY
DNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELY
SQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALA
DFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIY
VKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEG

--------------------------------------------------------------
>64755_64755_5_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000535894_ADCY8_chr8_132002788_ENST00000286355_length(transcript)=4665nt_BP=1780nt
ATATTTGAGCATGTATCGGAATCACCTGGGGGGCTTGTTAAACCGCAGATGGCTGGGCCCCACCCCCAGGGTTTCTGAGTCAAGATCTTG
GAGTGGCTTTCTAACAAGCTTCCAGGTGCAGCAGCAGCAGCTGCTGCTGCTCTAGAGACCACACTCTTAGGAGCTCTGGTCTAGTTATAC
TCACTTATCTTACGTACGAGAGAACTGAGTTTCAAAGCAACCAAGAGTCTTACCAAGGTTATTTAGCTAGCAGCTAGAGTCTGGTTTCGT
GACATTGAACCAACTGGGTTTTGGAATACCGTGTCAACACTGAGAAGGATGAACTGATATCAAATATCTTGCGTATGTTTCCGAGGGTGG
TTTACCGGATGGTGGTCTGCTACAACTCAGCCATTTATTGTGGTCTGTTTTTTCAGTGAGTCAAGGTCTCTTAAGTCTCCAAGCTAAACA
GGAGTACTGCCTGAAGCCAGAATGCATCGAAGCGGCTGCTGCCATCTTAAGTAAAGTAAATCTGTCTGTGGATCCTTGTGATAATTTCTT
CCGGTTCGCTTGTGATGGCTGGATAAGCAATAATCCAATTCCCGAAGATATGCCAAGCTATGGGGTTTATCCTTGGCTGAGACATAATGT
TGACCTCAAGTTGAAGGAACTTTTGGAGAAATCAATCAGTAGAAGGCGGGACACCGAAGCCATACAGAAAGCCAAAATCCTTTATTCATC
CTGCATGAATGAGAAAGCGATTGAAAAAGCAGATGCCAAGCCACTGCTACACATCCTACGGCATTCACCTTTCCGCTGGCCCGTGCTTGA
ATCTAATATTGGCCCTGAAGGGGTTTGGTCAGAGAGAAAGTTCAGCCTTCTGCAGACACTTGCAACGTTTCGTGGTCAATACAGCAATTC
TGTGTTCATCCGTTTGTATGTGTCCCCTGATGACAAAGCATCCAATGAACATATCTTGAAGCTGGACCAAGCAACACTCTCCCTGGCCGT
GAGGGAAGACTACCTTGATAACAGTACAGAAGCCAAGTCTTATCGGGATGCCCTTTACAAGTTCATGGTGGATACTGCCGTGCTTTTAGG
AGCTAACAGTTCCAGAGCAGAGCATGACATGAAGTCAGTGCTCAGATTGGAAATTAAGATAGCTGAGATAATGATTCCACATGAAAACCG
AACCAGCGAGGCCATGTACAACAAAATGAACATTTCTGAACTGAGTGCTATGATTCCCCAGTTCGACTGGCTGGGCTACATCAAGAAGGT
CATTGACACCAGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTGGTCCGCGTCCCGCAGTACTTTAAAGATTTGTT
TAGGATATTAGGGTCTGAGAGAAAGAAGACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGGCG
CTTTCAGTATAGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTGCCTCAATGGGACAAATGTGTAAACTTTATTGA
AAGTGCCCTCCCTTATGTTGTTGGAAAGATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAGGG
CGTTCGCTGGGCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGAACGAAAAGGAAAGCCAAAGAAAAGGCGAGAGC
TGTTTTGGCAAAAGTTGGCTATCCAGAGTTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTGTTGTGGCCCAGGCAGTGCT
ATTCATGTGTATGAACACAGCTGGAATCTTCATCAGTTACCTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTGT
GGAGGCCAGGCTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGGTTTGTTGTCCTGGAAATGAT
CAACGACATGACCAATGTGGAAGATGAGCACCTGCAGCACCAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTT
TGCAGATGTTAAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAGCTCTTTGCCAGATTTGA
TCGACTGGCCCATGAGCATCACTGCCTTCGTATTAAAATCCTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGGA
CCATGCCCACTGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACAAAACACGATGTTGACATGAG
GATTGGAATCCACTCCGGCTCGGTGCTGTGCGGTGTTTTGGGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTGC
AAACAAACTCGAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAACGGTGACTATAACGTGGAAGA
GGGCCATGGTAAAGAGAGGAATGAATTCCTGAGGAAGCATAATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCTT
GCCTGAAGATATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAAGGATCCTGGAGCCCTGAACT
GCCCTTTGATAATATCGTGGGGAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAGC
TTTGCATGTCCAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGCGATAAATTGAGAAGAGAGCA
TATCAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCACAAGTATTCTCAAATGAGGGATGAAGTGTTCAAGTCAAACTTGGT
CTGTGCATTTATCGTTCTTCTATTTATCACGGCAATACAAAGTTTGCTTCCTTCTTCAAGAGTGATGCCAATGACCATCCAGTTCTCCAT
TCTGATTATGCTGCACTCGGCTCTGGTCCTCATCACCACAGCAGAGGATTATAAATGTTTGCCCCTCATCCTCCGGAAAACTTGCTGTTG
GATTAATGAGACCTATTTGGCCCGGAACGTCATCATCTTTGCATCCATTTTGATTAATTTCCTGGGTGCCATCTTAAATATCCTGTGGTG
TGATTTTGACAAGTCGATACCCTTGAAGAACCTGACTTTCAATTCCTCAGCTGTGTTTACAGATATCTGCTCCTACCCAGAGTACTTTGT
CTTCACGGGGGTGTTGGCCATGGTGACCTGTGCAGTTTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCAGTGCTGCTGATCATGATTGC
CATCTATGCCCTGCTCACTGAGACCGTCTACGCAGGCCTCTTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGAC
CAAGGAGGTATCACTGCTACTGATGGCCATGTTCCTCCTGGCTGTGTTCTACCATGGACAGCAGCTGGAGTACACAGCCCGCCTGGACTT
CCTTTGGCGAGTACAGGCCAAAGAGGAGATCAATGAGATGAAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAG
CCATGTGGCCCGCCATTTCCTAGAGAAGGACCGAGACAATGAGGAGCTGTATTCTCAATCCTATGATGCTGTTGGGGTGATGTTTGCCTC
CATCCCAGGATTTGCGGACTTTTACTCTCAGACTGAAATGAATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGA
CTTCGATGAGTTGCTTGGTGAAGACCGATTTCAAGACATTGAAAAGATTAAGACCATTGGCAGCACCTACATGGCCGTGTCAGGCCTGTC
ACCTGAAAAACAGCAATGTGAAGACAAGTGGGGACATTTGTGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGAT
CAACAAGCATTCATTCAACAATTTTGAACTCCGGATTGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTTATCGGCGCTAAGAAACCACA
GTATGACATTTGGGGCAAAACTGTGAACCTGGCAAGCCGAATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTA
TCTCATCCTGAAGGACCAGGGCTTTGCCTTTGATTACCGAGGGGAGATCTATGTGAAGGGTATCAGTGAACAGGAAGGAAAAATCAAAAC
GTACTTTCTTCTGGGAAGAGTCCAACCCAACCCATTCATCTTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCT
GGGACTTGTCCAGTCCCTCAATAGGCAAAGGCAGAAGCAGCTACTCAATGAGAACAACAACACAGGAATCATCAAGGGTCATTACAACCG
GCGGACTTTGTTGTCACCCAGCGGCACAGAGCCTGGAGCCCAGGCTGAAGGCACCGACAAATCTGATTTGCCATAAAAGCATTTTCTTTC

>64755_64755_5_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000535894_ADCY8_chr8_132002788_ENST00000286355_length(amino acids)=1399AA_BP=468
MLQLSHLLWSVFSVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLK
ELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRL
YVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAM
YNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRW
LEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKV
GYPEFIMNDTHVNEDLKAVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTN
VEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCC
VEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKE
RNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQS
GPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLH
SALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVL
AMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQ
AKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELL
GEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWG
KTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQS

--------------------------------------------------------------
>64755_64755_6_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000535894_ADCY8_chr8_132002788_ENST00000377928_length(transcript)=4183nt_BP=1780nt
ATATTTGAGCATGTATCGGAATCACCTGGGGGGCTTGTTAAACCGCAGATGGCTGGGCCCCACCCCCAGGGTTTCTGAGTCAAGATCTTG
GAGTGGCTTTCTAACAAGCTTCCAGGTGCAGCAGCAGCAGCTGCTGCTGCTCTAGAGACCACACTCTTAGGAGCTCTGGTCTAGTTATAC
TCACTTATCTTACGTACGAGAGAACTGAGTTTCAAAGCAACCAAGAGTCTTACCAAGGTTATTTAGCTAGCAGCTAGAGTCTGGTTTCGT
GACATTGAACCAACTGGGTTTTGGAATACCGTGTCAACACTGAGAAGGATGAACTGATATCAAATATCTTGCGTATGTTTCCGAGGGTGG
TTTACCGGATGGTGGTCTGCTACAACTCAGCCATTTATTGTGGTCTGTTTTTTCAGTGAGTCAAGGTCTCTTAAGTCTCCAAGCTAAACA
GGAGTACTGCCTGAAGCCAGAATGCATCGAAGCGGCTGCTGCCATCTTAAGTAAAGTAAATCTGTCTGTGGATCCTTGTGATAATTTCTT
CCGGTTCGCTTGTGATGGCTGGATAAGCAATAATCCAATTCCCGAAGATATGCCAAGCTATGGGGTTTATCCTTGGCTGAGACATAATGT
TGACCTCAAGTTGAAGGAACTTTTGGAGAAATCAATCAGTAGAAGGCGGGACACCGAAGCCATACAGAAAGCCAAAATCCTTTATTCATC
CTGCATGAATGAGAAAGCGATTGAAAAAGCAGATGCCAAGCCACTGCTACACATCCTACGGCATTCACCTTTCCGCTGGCCCGTGCTTGA
ATCTAATATTGGCCCTGAAGGGGTTTGGTCAGAGAGAAAGTTCAGCCTTCTGCAGACACTTGCAACGTTTCGTGGTCAATACAGCAATTC
TGTGTTCATCCGTTTGTATGTGTCCCCTGATGACAAAGCATCCAATGAACATATCTTGAAGCTGGACCAAGCAACACTCTCCCTGGCCGT
GAGGGAAGACTACCTTGATAACAGTACAGAAGCCAAGTCTTATCGGGATGCCCTTTACAAGTTCATGGTGGATACTGCCGTGCTTTTAGG
AGCTAACAGTTCCAGAGCAGAGCATGACATGAAGTCAGTGCTCAGATTGGAAATTAAGATAGCTGAGATAATGATTCCACATGAAAACCG
AACCAGCGAGGCCATGTACAACAAAATGAACATTTCTGAACTGAGTGCTATGATTCCCCAGTTCGACTGGCTGGGCTACATCAAGAAGGT
CATTGACACCAGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTGGTCCGCGTCCCGCAGTACTTTAAAGATTTGTT
TAGGATATTAGGGTCTGAGAGAAAGAAGACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGGCG
CTTTCAGTATAGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTGCCTCAATGGGACAAATGTGTAAACTTTATTGA
AAGTGCCCTCCCTTATGTTGTTGGAAAGATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAGGG
CGTTCGCTGGGCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGAACGAAAAGGAAAGCCAAAGAAAAGGCGAGAGC
TGTTTTGGCAAAAGTTGGCTATCCAGAGTTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTGTTGTGGCCCAGGCAGTGCT
ATTCATGTGTATGAACACAGCTGGAATCTTCATCAGTTACCTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTGT
GGAGGCCAGGCTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGGTTTGTTGTCCTGGAAATGAT
CAACGACATGACCAATGTGGAAGATGAGCACCTGCAGCACCAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTT
TGCAGATGTTAAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAGCTCTTTGCCAGATTTGA
TCGACTGGCCCATGAGCATCACTGCCTTCGTATTAAAATCCTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGGA
CCATGCCCACTGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACAAAACACGATGTTGACATGAG
GATTGGAATCCACTCCGGCTCGGTGCTGTGCGGTGTTTTGGGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTGC
AAACAAACTCGAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAACGGTGACTATAACGTGGAAGA
GGGCCATGGTAAAGAGAGGAATGAATTCCTGAGGAAGCATAATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCTT
GCCTGAAGATATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAAGGATCCTGGAGCCCTGAACT
GCCCTTTGATAATATCGTGGGGAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAGC
TTTGCATGTCCAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGCGATAAATTGAGAAGAGAGCA
TATCAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCACAAGTACTTTGTCTTCACGGGGGTGTTGGCCATGGTGACCTGTGC
AGTTTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCAGTGCTGCTGATCATGATTGCCATCTATGCCCTGCTCACTGAGACCGTCTACGC
AGGCCTCTTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGACCAAGGAGGTATCACTGCTACTGATGGCCATGTT
CCTCCTGGCTGTGTTCTACCATGGACAGCAGCTGGAGTACACAGCCCGCCTGGACTTCCTTTGGCGAGTACAGGCCAAAGAGGAGATCAA
TGAGATGAAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAGCCATGTGGCCCGCCATTTCCTAGAGAAGGACCG
AGACAATGAGGAGCTGTATTCTCAATCCTATGATGCTGTTGGGGTGATGTTTGCCTCCATCCCAGGATTTGCGGACTTTTACTCTCAGAC
TGAAATGAATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGACTTCGATGAGTTGCTTGGTGAAGACCGATTTCA
AGACATTGAAAAGATTAAGACCATTGGCAGCACCTACATGGCCGTGTCAGGCCTGTCACCTGAAAAACAGCAATGTGAAGACAAGTGGGG
ACATTTGTGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGATCAACAAGCATTCATTCAACAATTTTGAACTCCG
GATTGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTTATCGGCGCTAAGAAACCACAGTATGACATTTGGGGCAAAACTGTGAACCTGGC
AAGCCGAATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTATCTCATCCTGAAGGACCAGGGCTTTGCCTTTGA
TTACCGAGGGGAGATCTATGTGAAGGGTATCAGTGAACAGGAAGGAAAAATCAAAACGTACTTTCTTCTGGGAAGAGTCCAACCCAACCC
ATTCATCTTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCTGGGACTTGTCCAGTCCCTCAATAGGCAAAGGCA
GAAGCAGCTACTCAATGAGAACAACAACACAGGAATCATCAAGGGTCATTACAACCGGCGGACTTTGTTGTCACCCAGCGGCACAGAGCC

>64755_64755_6_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000535894_ADCY8_chr8_132002788_ENST00000377928_length(amino acids)=1269AA_BP=468
MLQLSHLLWSVFSVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLK
ELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRL
YVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAM
YNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRW
LEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKV
GYPEFIMNDTHVNEDLKAVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTN
VEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCC
VEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKE
RNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQS
GPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLR
YDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEEL
YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCAL
ADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEI
YVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAE

--------------------------------------------------------------
>64755_64755_7_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000537599_ADCY8_chr8_132002788_ENST00000286355_length(transcript)=4475nt_BP=1590nt
ATTAGTAGAAGAGCAAGAAAGCCTTGGATGTCAACGCCTCGCTCTTGAGACCAGCCACCAAACCACGAAAAGTGACTTTCTTCTCGTGTG
CTCTCTACGGCCCTTCTGATGGAAGCAGAAACAGGGAGCAGCGTGGAGACTGGAAAGAAGGCCAACAGAGGCACTCGAATTGCCCTGGTC
GTGTTTGTCGGTGGCACCCTAGTTCTGGGCACGATCCTCTTTCTAGTGAGTCAAGGTCTCTTAAGTCTCCAAGCTAAACAGGAGTACTGC
CTGAAGCCAGAATGCATCGAAGCGGCTGCTGCCATCTTAAGTAAAGTAAATCTGTCTGTGGATCCTTGTGATAATTTCTTCCGGTTCGCT
TGTGATGGCTGGATAAGCAATAATCCAATTCCCGAAGATATGCCAAGCTATGGGGTTTATCCTTGGCTGAGACATAATGTTGACCTCAAG
TTGAAGGAACTTTTGGAGAAATCAATCAGTAGAAGGCGGGACACCGAAGCCATACAGAAAGCCAAAATCCTTTATTCATCCTGCATGAAT
GAGAAAGCGATTGAAAAAGCAGATGCCAAGCCACTGCTACACATCCTACGGCATTCACCTTTCCGCTGGCCCGTGCTTGAATCTAATATT
GGCCCTGAAGGGGTTTGGTCAGAGAGAAAGTTCAGCCTTCTGCAGACACTTGCAACGTTTCGTGGTCAATACAGCAATTCTGTGTTCATC
CGTTTGTATGTGTCCCCTGATGACAAAGCATCCAATGAACATATCTTGAAGCTGGACCAAGCAACACTCTCCCTGGCCGTGAGGGAAGAC
TACCTTGATAACAGTACAGAAGCCAAGTCTTATCGGGATGCCCTTTACAAGTTCATGGTGGATACTGCCGTGCTTTTAGGAGCTAACAGT
TCCAGAGCAGAGCATGACATGAAGTCAGTGCTCAGATTGGAAATTAAGATAGCTGAGATAATGATTCCACATGAAAACCGAACCAGCGAG
GCCATGTACAACAAAATGAACATTTCTGAACTGAGTGCTATGATTCCCCAGTTCGACTGGCTGGGCTACATCAAGAAGGTCATTGACACC
AGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTGGTCCGCGTCCCGCAGTACTTTAAAGATTTGTTTAGGATATTA
GGGTCTGAGAGAAAGAAGACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGGCGCTTTCAGTAT
AGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTGCCTCAATGGGACAAATGTGTAAACTTTATTGAAAGTGCCCTC
CCTTATGTTGTTGGAAAGATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAGGGCGTTCGCTGG
GCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGAACGAAAAGGAAAGCCAAAGAAAAGGCGAGAGCTGTTTTGGCA
AAAGTTGGCTATCCAGAGTTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTGTTGTGGCCCAGGCAGTGCTATTCATGTGT
ATGAACACAGCTGGAATCTTCATCAGTTACCTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTGTGGAGGCCAGG
CTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGGTTTGTTGTCCTGGAAATGATCAACGACATG
ACCAATGTGGAAGATGAGCACCTGCAGCACCAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTTTGCAGATGTT
AAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAGCTCTTTGCCAGATTTGATCGACTGGCC
CATGAGCATCACTGCCTTCGTATTAAAATCCTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGGACCATGCCCAC
TGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACAAAACACGATGTTGACATGAGGATTGGAATC
CACTCCGGCTCGGTGCTGTGCGGTGTTTTGGGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTGCAAACAAACTC
GAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAACGGTGACTATAACGTGGAAGAGGGCCATGGT
AAAGAGAGGAATGAATTCCTGAGGAAGCATAATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCTTGCCTGAAGAT
ATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAAGGATCCTGGAGCCCTGAACTGCCCTTTGAT
AATATCGTGGGGAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAGCTTTGCATGTC
CAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGCGATAAATTGAGAAGAGAGCATATCAAGCCA
TTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCACAAGTATTCTCAAATGAGGGATGAAGTGTTCAAGTCAAACTTGGTCTGTGCATTT
ATCGTTCTTCTATTTATCACGGCAATACAAAGTTTGCTTCCTTCTTCAAGAGTGATGCCAATGACCATCCAGTTCTCCATTCTGATTATG
CTGCACTCGGCTCTGGTCCTCATCACCACAGCAGAGGATTATAAATGTTTGCCCCTCATCCTCCGGAAAACTTGCTGTTGGATTAATGAG
ACCTATTTGGCCCGGAACGTCATCATCTTTGCATCCATTTTGATTAATTTCCTGGGTGCCATCTTAAATATCCTGTGGTGTGATTTTGAC
AAGTCGATACCCTTGAAGAACCTGACTTTCAATTCCTCAGCTGTGTTTACAGATATCTGCTCCTACCCAGAGTACTTTGTCTTCACGGGG
GTGTTGGCCATGGTGACCTGTGCAGTTTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCAGTGCTGCTGATCATGATTGCCATCTATGCC
CTGCTCACTGAGACCGTCTACGCAGGCCTCTTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGACCAAGGAGGTA
TCACTGCTACTGATGGCCATGTTCCTCCTGGCTGTGTTCTACCATGGACAGCAGCTGGAGTACACAGCCCGCCTGGACTTCCTTTGGCGA
GTACAGGCCAAAGAGGAGATCAATGAGATGAAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAGCCATGTGGCC
CGCCATTTCCTAGAGAAGGACCGAGACAATGAGGAGCTGTATTCTCAATCCTATGATGCTGTTGGGGTGATGTTTGCCTCCATCCCAGGA
TTTGCGGACTTTTACTCTCAGACTGAAATGAATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGACTTCGATGAG
TTGCTTGGTGAAGACCGATTTCAAGACATTGAAAAGATTAAGACCATTGGCAGCACCTACATGGCCGTGTCAGGCCTGTCACCTGAAAAA
CAGCAATGTGAAGACAAGTGGGGACATTTGTGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGATCAACAAGCAT
TCATTCAACAATTTTGAACTCCGGATTGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTTATCGGCGCTAAGAAACCACAGTATGACATT
TGGGGCAAAACTGTGAACCTGGCAAGCCGAATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTATCTCATCCTG
AAGGACCAGGGCTTTGCCTTTGATTACCGAGGGGAGATCTATGTGAAGGGTATCAGTGAACAGGAAGGAAAAATCAAAACGTACTTTCTT
CTGGGAAGAGTCCAACCCAACCCATTCATCTTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCTGGGACTTGTC
CAGTCCCTCAATAGGCAAAGGCAGAAGCAGCTACTCAATGAGAACAACAACACAGGAATCATCAAGGGTCATTACAACCGGCGGACTTTG
TTGTCACCCAGCGGCACAGAGCCTGGAGCCCAGGCTGAAGGCACCGACAAATCTGATTTGCCATAAAAGCATTTTCTTTCTGTTTTTTTT

>64755_64755_7_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000537599_ADCY8_chr8_132002788_ENST00000286355_length(amino acids)=1426AA_BP=495
MMEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI
SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGV
WSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEH
DMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERK
KTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDM
LEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLET
ENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHC
LRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGI
PGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGK
QNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLF
ITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPL
KNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLM
AMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFY
SQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNF
ELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQ

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>64755_64755_8_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000537599_ADCY8_chr8_132002788_ENST00000377928_length(transcript)=3993nt_BP=1590nt
ATTAGTAGAAGAGCAAGAAAGCCTTGGATGTCAACGCCTCGCTCTTGAGACCAGCCACCAAACCACGAAAAGTGACTTTCTTCTCGTGTG
CTCTCTACGGCCCTTCTGATGGAAGCAGAAACAGGGAGCAGCGTGGAGACTGGAAAGAAGGCCAACAGAGGCACTCGAATTGCCCTGGTC
GTGTTTGTCGGTGGCACCCTAGTTCTGGGCACGATCCTCTTTCTAGTGAGTCAAGGTCTCTTAAGTCTCCAAGCTAAACAGGAGTACTGC
CTGAAGCCAGAATGCATCGAAGCGGCTGCTGCCATCTTAAGTAAAGTAAATCTGTCTGTGGATCCTTGTGATAATTTCTTCCGGTTCGCT
TGTGATGGCTGGATAAGCAATAATCCAATTCCCGAAGATATGCCAAGCTATGGGGTTTATCCTTGGCTGAGACATAATGTTGACCTCAAG
TTGAAGGAACTTTTGGAGAAATCAATCAGTAGAAGGCGGGACACCGAAGCCATACAGAAAGCCAAAATCCTTTATTCATCCTGCATGAAT
GAGAAAGCGATTGAAAAAGCAGATGCCAAGCCACTGCTACACATCCTACGGCATTCACCTTTCCGCTGGCCCGTGCTTGAATCTAATATT
GGCCCTGAAGGGGTTTGGTCAGAGAGAAAGTTCAGCCTTCTGCAGACACTTGCAACGTTTCGTGGTCAATACAGCAATTCTGTGTTCATC
CGTTTGTATGTGTCCCCTGATGACAAAGCATCCAATGAACATATCTTGAAGCTGGACCAAGCAACACTCTCCCTGGCCGTGAGGGAAGAC
TACCTTGATAACAGTACAGAAGCCAAGTCTTATCGGGATGCCCTTTACAAGTTCATGGTGGATACTGCCGTGCTTTTAGGAGCTAACAGT
TCCAGAGCAGAGCATGACATGAAGTCAGTGCTCAGATTGGAAATTAAGATAGCTGAGATAATGATTCCACATGAAAACCGAACCAGCGAG
GCCATGTACAACAAAATGAACATTTCTGAACTGAGTGCTATGATTCCCCAGTTCGACTGGCTGGGCTACATCAAGAAGGTCATTGACACC
AGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTGGTCCGCGTCCCGCAGTACTTTAAAGATTTGTTTAGGATATTA
GGGTCTGAGAGAAAGAAGACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGGCGCTTTCAGTAT
AGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTGCCTCAATGGGACAAATGTGTAAACTTTATTGAAAGTGCCCTC
CCTTATGTTGTTGGAAAGATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAGGGCGTTCGCTGG
GCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGAACGAAAAGGAAAGCCAAAGAAAAGGCGAGAGCTGTTTTGGCA
AAAGTTGGCTATCCAGAGTTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTGTTGTGGCCCAGGCAGTGCTATTCATGTGT
ATGAACACAGCTGGAATCTTCATCAGTTACCTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTGTGGAGGCCAGG
CTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGGTTTGTTGTCCTGGAAATGATCAACGACATG
ACCAATGTGGAAGATGAGCACCTGCAGCACCAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTTTGCAGATGTT
AAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAGCTCTTTGCCAGATTTGATCGACTGGCC
CATGAGCATCACTGCCTTCGTATTAAAATCCTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGGACCATGCCCAC
TGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACAAAACACGATGTTGACATGAGGATTGGAATC
CACTCCGGCTCGGTGCTGTGCGGTGTTTTGGGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTGCAAACAAACTC
GAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAACGGTGACTATAACGTGGAAGAGGGCCATGGT
AAAGAGAGGAATGAATTCCTGAGGAAGCATAATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCTTGCCTGAAGAT
ATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAAGGATCCTGGAGCCCTGAACTGCCCTTTGAT
AATATCGTGGGGAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAGCTTTGCATGTC
CAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGCGATAAATTGAGAAGAGAGCATATCAAGCCA
TTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCACAAGTACTTTGTCTTCACGGGGGTGTTGGCCATGGTGACCTGTGCAGTTTTCCTC
CGGCTGAACTCCGTCCTGAAGCTGGCAGTGCTGCTGATCATGATTGCCATCTATGCCCTGCTCACTGAGACCGTCTACGCAGGCCTCTTT
CTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGACCAAGGAGGTATCACTGCTACTGATGGCCATGTTCCTCCTGGCT
GTGTTCTACCATGGACAGCAGCTGGAGTACACAGCCCGCCTGGACTTCCTTTGGCGAGTACAGGCCAAAGAGGAGATCAATGAGATGAAG
GAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAGCCATGTGGCCCGCCATTTCCTAGAGAAGGACCGAGACAATGAG
GAGCTGTATTCTCAATCCTATGATGCTGTTGGGGTGATGTTTGCCTCCATCCCAGGATTTGCGGACTTTTACTCTCAGACTGAAATGAAT
AACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGACTTCGATGAGTTGCTTGGTGAAGACCGATTTCAAGACATTGAA
AAGATTAAGACCATTGGCAGCACCTACATGGCCGTGTCAGGCCTGTCACCTGAAAAACAGCAATGTGAAGACAAGTGGGGACATTTGTGT
GCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGATCAACAAGCATTCATTCAACAATTTTGAACTCCGGATTGGCATC
AGCCACGGCTCAGTGGTAGCTGGCGTTATCGGCGCTAAGAAACCACAGTATGACATTTGGGGCAAAACTGTGAACCTGGCAAGCCGAATG
GACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTATCTCATCCTGAAGGACCAGGGCTTTGCCTTTGATTACCGAGGG
GAGATCTATGTGAAGGGTATCAGTGAACAGGAAGGAAAAATCAAAACGTACTTTCTTCTGGGAAGAGTCCAACCCAACCCATTCATCTTG
CCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCTGGGACTTGTCCAGTCCCTCAATAGGCAAAGGCAGAAGCAGCTA
CTCAATGAGAACAACAACACAGGAATCATCAAGGGTCATTACAACCGGCGGACTTTGTTGTCACCCAGCGGCACAGAGCCTGGAGCCCAG

>64755_64755_8_PHEX-ADCY8_PHEX_chrX_22186506_ENST00000537599_ADCY8_chr8_132002788_ENST00000377928_length(amino acids)=1295AA_BP=495
MMEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI
SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGV
WSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEH
DMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERK
KTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDM
LEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLET
ENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHC
LRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGI
PGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGK
QNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYFVFTGVLAMVTCAVFLRLNSV
LKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREH
NENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTI
GSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGV
SGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENN

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Fusion Gene PPI Analysis for PHEX-ADCY8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHEX-ADCY8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHEX-ADCY8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource