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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF15-UBE2B (FusionGDB2 ID:64797)

Fusion Gene Summary for PHF15-UBE2B

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF15-UBE2B
Fusion gene ID: 64797
HgeneTgene
Gene symbol

PHF15

UBE2B

Gene ID

23338

7320

Gene namejade family PHD finger 2ubiquitin conjugating enzyme E2 B
SynonymsJADE-2|PHF15E2-17kDa|HHR6B|HR6B|RAD6B|UBC2
Cytomap

5q31.1

5q31.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Jade-2PHD finger protein 15jade family PHD finger protein 2ubiquitin-conjugating enzyme E2 BE2 proteinE2 ubiquitin-conjugating enzyme BRAD6 homolog Bubiquitin carrier protein Bubiquitin conjugating enzyme E2Bubiquitin-conjugating enzyme E2-17 kDaubiquitin-conjugating enzyme E2B (RAD6 homolog)ubiquitin-pro
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000515554, ENST00000282605, 
ENST00000361895, ENST00000395003, 
ENST00000402835, 		ENST00000265339, 
ENST00000511807, 
Fusion gene scores* DoF score3 X 3 X 4=365 X 5 X 3=75
# samples 46
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF15 [Title/Abstract] AND UBE2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF15(133909452)-UBE2B(133724016), # samples:1
PHF15(133861701)-UBE2B(133725916), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHF15

GO:0043966

histone H3 acetylation

16387653

HgenePHF15

GO:0043981

histone H4-K5 acetylation

16387653

HgenePHF15

GO:0043982

histone H4-K8 acetylation

16387653

HgenePHF15

GO:0043983

histone H4-K12 acetylation

16387653

HgenePHF15

GO:0043984

histone H4-K16 acetylation

16387653

TgeneUBE2B

GO:0006301

postreplication repair

14981545

TgeneUBE2B

GO:0006511

ubiquitin-dependent protein catabolic process

10373550

TgeneUBE2B

GO:0006974

cellular response to DNA damage stimulus

14981545

TgeneUBE2B

GO:0016567

protein ubiquitination

10373550|19123975

TgeneUBE2B

GO:0042493

response to drug

14981545

TgeneUBE2B

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

10373550

TgeneUBE2B

GO:0043951

negative regulation of cAMP-mediated signaling

10373550

TgeneUBE2B

GO:0051865

protein autoubiquitination

19123975

TgeneUBE2B

GO:0070534

protein K63-linked ubiquitination

20061386

TgeneUBE2B

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2B

GO:0070979

protein K11-linked ubiquitination

20061386


check buttonFusion gene breakpoints across PHF15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBE2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5JK-01APHF15chr5

133861701

-UBE2Bchr5

133725916

+
ChimerDB4LIHCTCGA-2Y-A9GY-01APHF15chr5

133909452

-UBE2Bchr5

133724016

+


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Fusion Gene ORF analysis for PHF15-UBE2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000515554ENST00000265339PHF15chr5

133861701

-UBE2Bchr5

133725916

+
3UTR-3UTRENST00000515554ENST00000511807PHF15chr5

133861701

-UBE2Bchr5

133725916

+
5CDS-intronENST00000282605ENST00000511807PHF15chr5

133909452

-UBE2Bchr5

133724016

+
5CDS-intronENST00000361895ENST00000511807PHF15chr5

133909452

-UBE2Bchr5

133724016

+
5CDS-intronENST00000395003ENST00000511807PHF15chr5

133909452

-UBE2Bchr5

133724016

+
5UTR-3CDSENST00000361895ENST00000265339PHF15chr5

133861701

-UBE2Bchr5

133725916

+
5UTR-3UTRENST00000361895ENST00000511807PHF15chr5

133861701

-UBE2Bchr5

133725916

+
In-frameENST00000282605ENST00000265339PHF15chr5

133909452

-UBE2Bchr5

133724016

+
In-frameENST00000361895ENST00000265339PHF15chr5

133909452

-UBE2Bchr5

133724016

+
In-frameENST00000395003ENST00000265339PHF15chr5

133909452

-UBE2Bchr5

133724016

+
intron-3CDSENST00000282605ENST00000265339PHF15chr5

133861701

-UBE2Bchr5

133725916

+
intron-3CDSENST00000395003ENST00000265339PHF15chr5

133861701

-UBE2Bchr5

133725916

+
intron-3CDSENST00000402835ENST00000265339PHF15chr5

133861701

-UBE2Bchr5

133725916

+
intron-3CDSENST00000402835ENST00000265339PHF15chr5

133909452

-UBE2Bchr5

133724016

+
intron-3CDSENST00000515554ENST00000265339PHF15chr5

133909452

-UBE2Bchr5

133724016

+
intron-3UTRENST00000282605ENST00000511807PHF15chr5

133861701

-UBE2Bchr5

133725916

+
intron-3UTRENST00000395003ENST00000511807PHF15chr5

133861701

-UBE2Bchr5

133725916

+
intron-3UTRENST00000402835ENST00000511807PHF15chr5

133861701

-UBE2Bchr5

133725916

+
intron-intronENST00000402835ENST00000511807PHF15chr5

133909452

-UBE2Bchr5

133724016

+
intron-intronENST00000515554ENST00000511807PHF15chr5

133909452

-UBE2Bchr5

133724016

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282605PHF15chr5133909452-ENST00000265339UBE2Bchr5133724016+34951638381855605
ENST00000361895PHF15chr5133909452-ENST00000265339UBE2Bchr5133724016+374818913392108589
ENST00000395003PHF15chr5133909452-ENST00000265339UBE2Bchr5133724016+3588173151948647

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282605ENST00000265339PHF15chr5133909452-UBE2Bchr5133724016+0.0008639950.99913603
ENST00000361895ENST00000265339PHF15chr5133909452-UBE2Bchr5133724016+0.0033800240.99661994
ENST00000395003ENST00000265339PHF15chr5133909452-UBE2Bchr5133724016+0.0032386650.9967614

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Fusion Genomic Features for PHF15-UBE2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHF15-UBE2B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:133909452/chr5:133724016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBE2Bchr5:133909452chr5:133724016ENST00000265339364_15080153.0DomainUBC core


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Fusion Gene Sequence for PHF15-UBE2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64797_64797_1_PHF15-UBE2B_PHF15_chr5_133909452_ENST00000282605_UBE2B_chr5_133724016_ENST00000265339_length(transcript)=3495nt_BP=1638nt
TTTAAAAAGAAACAGAAACATACACAGGGGGTTGGTGAATGGTGCCGACCGCGGCCATCGCAGTTGGAGGCTATTTTTTGGGGGGGATGG
AAGAGAAGAGGCGAAAATACTCCATCAGCAGTGACAACTCTGACACCACTGACAGTCATGCGACATCTACATCCGCATCAAGATGCTCCA
AACTGCCCAGCAGCACCAAGTCGGGCTGGCCCCGACAGAACGAAAAGAAGCCCTCCGAGGTTTTCCGGACAGACTTGATCACAGCCATGA
AGATCCCGGACTCATACCAGCTCAGCCCGGATGACTACTACATCCTGGCAGACCCATGGCGACAGGAATGGGAGAAAGGTGTGCAGGTGC
CTGCCGGGGCAGAGGCCATCCCAGAGCCCGTGGTGAGGATCCTCCCACCACTGGAAGGCCCCCCTGCCCAGGCATCCCCGAGCAGCACCA
TGCTTGGTGAGGGCTCCCAGCCTGATTGGCCAGGGGGCAGCCGCTATGACTTGGACGAGATTGATGCCTACTGGCTGGAGCTCATCAACT
CGGAGCTTAAGGAGATGGAGAGGCCGGAGCTGGACGAGCTGACATTAGAGCGTGTGCTGGAGGAGCTGGAGACCCTGTGCCACCAGAATA
TGGCCAGGGCCATTGAGACGCAGGAGGGGCTGGGCATCGAGTACGACGAGGATGTTGTCTGCGACGTGTGTCGCTCTCCTGAGGGCGAGG
ATGGCAACGAGATGGTCTTCTGTGACAAGTGCAACGTCTGTGTGCATCAGGCATGCTACGGGATCCTCAAGGTGCCCACGGGCAGCTGGC
TGTGCCGGACGTGTGCCCTGGGTGTCCAGCCAAAGTGCCTGCTCTGCCCCAAGCGAGGAGGAGCCTTGAAGCCCACTAGAAGTGGGACCA
AGTGGGTGCATGTCAGCTGTGCCCTATGGATTCCTGAGGTCAGCATCGGCTGCCCAGAGAAGATGGAGCCCATCACCAAGATCTCGCATA
TCCCAGCCAGCCGCTGGGCTCTGTCCTGCAGCCTCTGCAAGGAATGCACAGGCACCTGCATCCAGTGTTCCATGCCTTCCTGCGTCACAG
CGTTCCATGTCACATGCGCCTTTGACCACGGCCTGGAAATGCGGACTATATTAGCAGACAACGATGAGGTCAAGTTCAAGTCATTCTGCC
AGGAGCACAGTGACGGGGGCCCACGTAATGAGCCCACATCTGAGCCCACGGAACCCAGCCAGGCTGGCGAGGACCTGGAAAAGGTGACCC
TGCGCAAGCAGCGGCTGCAGCAGCTAGAGGAGGACTTCTACGAGCTGGTGGAGCCGGCTGAGGTGGCTGAGCGGCTGGACCTGGCTGAGG
CACTGGTCGACTTCATCTACCAGTACTGGAAGCTGAAGAGGAAAGCCAATGCCAACCAGCCGCTGCTGACCCCCAAGACCGACGAGGTGG
ACAACCTGGCCCAGCAGGAGCAGGACGTCCTCTACCGCCGCCTGAAGCTCTTCACCCATCTGCGGCAGGACCTAGAGAGGGTTAGAAATC
TGTGCTACATGGTGACAAGGCGCGAGAGAACGAAACACGCCATCTGCAAACTCCAGGAGCAGATATTCCACCTGCAGATGAAACTTATTG
AACAGGATCTGTGTCGAGTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATCGATGGAGTCCAACATATGATGTATCTTCTA
TCTTAACATCAATTCAGTCTCTGCTGGATGAACCGAATCCTAACAGTCCAGCCAATAGCCAGGCAGCACAGCTTTATCAGGAAAACAAAC
GAGAATATGAGAAAAGAGTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAATAGACAACTGGTCTGTTAATCTTTTTCATCATTG
TTGTGTATAATTTACCTCTCATTAGAAAGGCTAACAAATTTTAAGTGCCACAGGTTTTAAGGATTCTGCAGAAAAAAAAGAAAAAAGTCC
TTCAGTTTAGAACCTACAAAAGCTTGTGTATCTTGATTAATGTACTTTTTATTGCATGGTGTGAACTAAGTTATTGCTGCATAAATTTGT
AATATATCCTGTTTGTATTTTTTTCCAAGTGTATAATGTTGGTGTGGAGTTTTCATGACAGAATATACACATTTTGTAAATCTGTACTTT
TTTCAAATATTGAATGCCTTATTTTTGAATTCTTTAGATTTTTAAATTGGAGAAAAGCACTTAAAGTTTTTTATATATGAATATTACATG
TAAAGCTGTTAAAATACATAACTTCAGTGCAAGAGACTTTGTCACTTATTTCCTTATGTGTGTAGGAGGGGTTAATAAGTCTCTAGCTCT
CCATCTATTGATAGTTTCATTTACAATTTCAAAAGAACATTCTTATATTTTATCAAGGAAGTCTTCAAATTTGATTCTAAATAGCGATTA
TAATCTCCAACTTTATTTTGAATGTACCTCTATTAGTTTCAATTGAGTAATTCTAGACATAACTGGTTTGACTCTGTCCAACTCTGTATT
TAGGCCATTTGTTACAGTTTCTTCATGCATTACTTACTGTTAAAACTGTACCTTTTGCGATTTCACAGTTGGCACTTCTGCCATGAGCAG
AGAACTGATGCGACTTGTTTTGCTGCTTGGTAGCACTTTAAAAAATTTTTTGATTAATGAAGAAAGTAAAACCATAAACATTTGCCAAAA
ATTCATGCCCCAGTATTAGCAATGAATTAGTTGCATTGGTTTGAGAAAGGCACATATTGGAGGGAAATCTTGGTGTAACTTAAATATTTG
AAAATTACCTTTAATGCAATGCATATCTGTTTATTCTGGGAAATGTTTTAATGCCAGGGCCTGCTGAGTTGCTTCTTCTTGTGGAGATTT
TTTTTTTAATCTCCTGAGTTGTATAAAAGTTGTACTGCATCTTAGTTTACTGGATAAATTTAAAACACAGTATTGTAGAAAGCTAATACA
AAACTATCCTATGCCTTCAAATAGTATAGAAAATGGAAAATATACAAGTAAATTCTGTTGAACCACCTGTGTAGTCTCTCTAGTAGTTAA
AACAGCTATTTTAGTAACCCCAAGAGTTTCTTCTCATATCCATAAAATTGGATTACAGTATGGCAATATCTACAGCTTCTATTCATTATG
CAACGTTTAACATTGATTGGATAAATGCTTATAGGCTGGGCCAGGTGGCTCCCACCTGTAGTCCCAGCACTTTGGGAGGCAAAGGCGGGA
GGATCACTTGAGGCCAGGACTTTGAGACCAGCCAGGGCAACATAATAAGACTTTTCTCTACTTTAAATTTTTTAAAAAATTAGTTGGGCA
TAGTGGCACTTGCCTGTAGTCTCAGCTACTTAGGAGGCTGAGGTGGCAGAATAGCTTATGCCTAGGAGGTTGAGGCTGCAGTGAGCTGTG

>64797_64797_1_PHF15-UBE2B_PHF15_chr5_133909452_ENST00000282605_UBE2B_chr5_133724016_ENST00000265339_length(amino acids)=605AA_BP=533
MVPTAAIAVGGYFLGGMEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDY
YILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDE
LTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKC
LLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLE
MRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLK
RKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRVYADGSI

--------------------------------------------------------------
>64797_64797_2_PHF15-UBE2B_PHF15_chr5_133909452_ENST00000361895_UBE2B_chr5_133724016_ENST00000265339_length(transcript)=3748nt_BP=1891nt
AACATACACAGGGGGTTGGTGAATGGTGCCGACCGCGGCCATCGCAGTTGGAGGCTATTTTTTGGGGGGGGTGAGTAGCGTCCATGGAGT
TACTTTGCGCCCACTCCTAGCGGCACCGGCTTAGGTCCTGCGGGCCGACCGTCCCCGGCGGGGGGCGTGGGGCCTGGGACGCCGCGGGCC
CGGCCGCCTCCCTCGCCGCGACCCCGGATGGATGCGCGCCCCCCGCCCTCCCGCGCCGGCCCCAGGAGCTCCCGGCTTCGGGAGCATCCT
TCCCGCGCCGGTCCCTGCAGCGGCGCGTAGCCGAGGGCAGCGCCCGTCAGGGGGGCACCGCGGAGCAAGATGGAAGAGAAGAGGCGAAAA
TACTCCATCAGCAGTGACAACTCTGACACCACTGACAGTCATGCGACATCTACATCCGCATCAAGATGCTCCAAACTGCCCAGCAGCACC
AAGTCGGGCTGGCCCCGACAGAACGAAAAGAAGCCCTCCGAGGTTTTCCGGACAGACTTGATCACAGCCATGAAGATCCCGGACTCATAC
CAGCTCAGCCCGGATGACTACTACATCCTGGCAGACCCATGGCGACAGGAATGGGAGAAAGGTGTGCAGGTGCCTGCCGGGGCAGAGGCC
ATCCCAGAGCCCGTGGTGAGGATCCTCCCACCACTGGAAGGCCCCCCTGCCCAGGCATCCCCGAGCAGCACCATGCTTGGTGAGGGCTCC
CAGCCTGATTGGCCAGGGGGCAGCCGCTATGACTTGGACGAGATTGATGCCTACTGGCTGGAGCTCATCAACTCGGAGCTTAAGGAGATG
GAGAGGCCGGAGCTGGACGAGCTGACATTAGAGCGTGTGCTGGAGGAGCTGGAGACCCTGTGCCACCAGAATATGGCCAGGGCCATTGAG
ACGCAGGAGGGGCTGGGCATCGAGTACGACGAGGATGTTGTCTGCGACGTGTGTCGCTCTCCTGAGGGCGAGGATGGCAACGAGATGGTC
TTCTGTGACAAGTGCAACGTCTGTGTGCATCAGGCATGCTACGGGATCCTCAAGGTGCCCACGGGCAGCTGGCTGTGCCGGACGTGTGCC
CTGGGTGTCCAGCCAAAGTGCCTGCTCTGCCCCAAGCGAGGAGGAGCCTTGAAGCCCACTAGAAGTGGGACCAAGTGGGTGCATGTCAGC
TGTGCCCTATGGATTCCTGAGGTCAGCATCGGCTGCCCAGAGAAGATGGAGCCCATCACCAAGATCTCGCATATCCCAGCCAGCCGCTGG
GCTCTGTCCTGCAGCCTCTGCAAGGAATGCACAGGCACCTGCATCCAGTGTTCCATGCCTTCCTGCGTCACAGCGTTCCATGTCACATGC
GCCTTTGACCACGGCCTGGAAATGCGGACTATATTAGCAGACAACGATGAGGTCAAGTTCAAGTCATTCTGCCAGGAGCACAGTGACGGG
GGCCCACGTAATGAGCCCACATCTGAGCCCACGGAACCCAGCCAGGCTGGCGAGGACCTGGAAAAGGTGACCCTGCGCAAGCAGCGGCTG
CAGCAGCTAGAGGAGGACTTCTACGAGCTGGTGGAGCCGGCTGAGGTGGCTGAGCGGCTGGACCTGGCTGAGGCACTGGTCGACTTCATC
TACCAGTACTGGAAGCTGAAGAGGAAAGCCAATGCCAACCAGCCGCTGCTGACCCCCAAGACCGACGAGGTGGACAACCTGGCCCAGCAG
GAGCAGGACGTCCTCTACCGCCGCCTGAAGCTCTTCACCCATCTGCGGCAGGACCTAGAGAGGGTTAGAAATCTGTGCTACATGGTGACA
AGGCGCGAGAGAACGAAACACGCCATCTGCAAACTCCAGGAGCAGATATTCCACCTGCAGATGAAACTTATTGAACAGGATCTGTGTCGA
GTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATCGATGGAGTCCAACATATGATGTATCTTCTATCTTAACATCAATTCAG
TCTCTGCTGGATGAACCGAATCCTAACAGTCCAGCCAATAGCCAGGCAGCACAGCTTTATCAGGAAAACAAACGAGAATATGAGAAAAGA
GTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAATAGACAACTGGTCTGTTAATCTTTTTCATCATTGTTGTGTATAATTTACCT
CTCATTAGAAAGGCTAACAAATTTTAAGTGCCACAGGTTTTAAGGATTCTGCAGAAAAAAAAGAAAAAAGTCCTTCAGTTTAGAACCTAC
AAAAGCTTGTGTATCTTGATTAATGTACTTTTTATTGCATGGTGTGAACTAAGTTATTGCTGCATAAATTTGTAATATATCCTGTTTGTA
TTTTTTTCCAAGTGTATAATGTTGGTGTGGAGTTTTCATGACAGAATATACACATTTTGTAAATCTGTACTTTTTTCAAATATTGAATGC
CTTATTTTTGAATTCTTTAGATTTTTAAATTGGAGAAAAGCACTTAAAGTTTTTTATATATGAATATTACATGTAAAGCTGTTAAAATAC
ATAACTTCAGTGCAAGAGACTTTGTCACTTATTTCCTTATGTGTGTAGGAGGGGTTAATAAGTCTCTAGCTCTCCATCTATTGATAGTTT
CATTTACAATTTCAAAAGAACATTCTTATATTTTATCAAGGAAGTCTTCAAATTTGATTCTAAATAGCGATTATAATCTCCAACTTTATT
TTGAATGTACCTCTATTAGTTTCAATTGAGTAATTCTAGACATAACTGGTTTGACTCTGTCCAACTCTGTATTTAGGCCATTTGTTACAG
TTTCTTCATGCATTACTTACTGTTAAAACTGTACCTTTTGCGATTTCACAGTTGGCACTTCTGCCATGAGCAGAGAACTGATGCGACTTG
TTTTGCTGCTTGGTAGCACTTTAAAAAATTTTTTGATTAATGAAGAAAGTAAAACCATAAACATTTGCCAAAAATTCATGCCCCAGTATT
AGCAATGAATTAGTTGCATTGGTTTGAGAAAGGCACATATTGGAGGGAAATCTTGGTGTAACTTAAATATTTGAAAATTACCTTTAATGC
AATGCATATCTGTTTATTCTGGGAAATGTTTTAATGCCAGGGCCTGCTGAGTTGCTTCTTCTTGTGGAGATTTTTTTTTTAATCTCCTGA
GTTGTATAAAAGTTGTACTGCATCTTAGTTTACTGGATAAATTTAAAACACAGTATTGTAGAAAGCTAATACAAAACTATCCTATGCCTT
CAAATAGTATAGAAAATGGAAAATATACAAGTAAATTCTGTTGAACCACCTGTGTAGTCTCTCTAGTAGTTAAAACAGCTATTTTAGTAA
CCCCAAGAGTTTCTTCTCATATCCATAAAATTGGATTACAGTATGGCAATATCTACAGCTTCTATTCATTATGCAACGTTTAACATTGAT
TGGATAAATGCTTATAGGCTGGGCCAGGTGGCTCCCACCTGTAGTCCCAGCACTTTGGGAGGCAAAGGCGGGAGGATCACTTGAGGCCAG
GACTTTGAGACCAGCCAGGGCAACATAATAAGACTTTTCTCTACTTTAAATTTTTTAAAAAATTAGTTGGGCATAGTGGCACTTGCCTGT
AGTCTCAGCTACTTAGGAGGCTGAGGTGGCAGAATAGCTTATGCCTAGGAGGTTGAGGCTGCAGTGAGCTGTGATTATGCCATTGCACTC

>64797_64797_2_PHF15-UBE2B_PHF15_chr5_133909452_ENST00000361895_UBE2B_chr5_133724016_ENST00000265339_length(amino acids)=589AA_BP=517
MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQ
VPAGAEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSG
TKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDE
VDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRVYADGSICLDILQNRWSPTYDVS

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>64797_64797_3_PHF15-UBE2B_PHF15_chr5_133909452_ENST00000395003_UBE2B_chr5_133724016_ENST00000265339_length(transcript)=3588nt_BP=1731nt
CTCTCTTGCTCGCTCGCTCCCTCTCTCTCCTGCTGGCTGCCTGTTCTAGGAAGCCAGCGCGGAGAGGGGGGGGATGCACAGCACAGGGGA
GAGAGATTGCGCATGTTGGTCAGTCGTGTTTTAAAGAGTACAGTGCGGGGAGGCTGAGAGGGGCGCATGCAACAACAACTTTTGGAAGGA
TGGAAGAGAAGAGGCGAAAATACTCCATCAGCAGTGACAACTCTGACACCACTGACAGTCATGCGACATCTACATCCGCATCAAGATGCT
CCAAACTGCCCAGCAGCACCAAGTCGGGCTGGCCCCGACAGAACGAAAAGAAGCCCTCCGAGGTTTTCCGGACAGACTTGATCACAGCCA
TGAAGATCCCGGACTCATACCAGCTCAGCCCGGATGACTACTACATCCTGGCAGACCCATGGCGACAGGAATGGGAGAAAGGTGTGCAGG
TGCCTGCCGGGGCAGAGGCCATCCCAGAGCCCGTGGTGAGGATCCTCCCACCACTGGAAGGCCCCCCTGCCCAGGCATCCCCGAGCAGCA
CCATGCTTGGTGAGGGCTCCCAGCCTGATTGGCCAGGGGGCAGCCGCTATGACTTGGACGAGATTGATGCCTACTGGCTGGAGCTCATCA
ACTCGGAGCTTAAGGAGATGGAGAGGCCGGAGCTGGACGAGCTGACATTAGAGCGTGTGCTGGAGGAGCTGGAGACCCTGTGCCACCAGA
ATATGGCCAGGGCCATTGAGACGCAGGAGGGGCTGGGCATCGAGTACGACGAGGATGTTGTCTGCGACGTGTGTCGCTCTCCTGAGGGCG
AGGATGGCAACGAGATGGTCTTCTGTGACAAGTGCAACGTCTGTGTGCATCAGGCATGCTACGGGATCCTCAAGGTGCCCACGGGCAGCT
GGCTGTGCCGGACGTGTGCCCTGGGTGTCCAGCCAAAGTGCCTGCTCTGCCCCAAGCGAGGAGGAGCCTTGAAGCCCACTAGAAGTGGGA
CCAAGTGGGTGCATGTCAGCTGTGCCCTATGGATTCCTGAGGTCAGCATCGGCTGCCCAGAGAAGATGGAGCCCATCACCAAGATCTCGC
ATATCCCAGCCAGCCGCTGGGCTCTGTCCTGCAGCCTCTGCAAGGAATGCACAGGCACCTGCATCCAGTGTTCCATGCCTTCCTGCGTCA
CAGCGTTCCATGTCACATGCGCCTTTGACCACGGCCTGGAAATGCGGACTATATTAGCAGACAACGATGAGGTCAAGTTCAAGTCATTCT
GCCAGGAGCACAGTGACGGGGGCCCACGTAATGAGCCCACATCTGAGCCCACGGAACCCAGCCAGGCTGGCGAGGACCTGGAAAAGGTGA
CCCTGCGCAAGCAGCGGCTGCAGCAGCTAGAGGAGGACTTCTACGAGCTGGTGGAGCCGGCTGAGGTGGCTGAGCGGCTGGACCTGGCTG
AGGCACTGGTCGACTTCATCTACCAGTACTGGAAGCTGAAGAGGAAAGCCAATGCCAACCAGCCGCTGCTGACCCCCAAGACCGACGAGG
TGGACAACCTGGCCCAGCAGGAGCAGGACGTCCTCTACCGCCGCCTGAAGCTCTTCACCCATCTGCGGCAGGACCTAGAGAGGGTTAGAA
ATCTGTGCTACATGGTGACAAGGCGCGAGAGAACGAAACACGCCATCTGCAAACTCCAGGAGCAGATATTCCACCTGCAGATGAAACTTA
TTGAACAGGATCTGTGTCGAGTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATCGATGGAGTCCAACATATGATGTATCTT
CTATCTTAACATCAATTCAGTCTCTGCTGGATGAACCGAATCCTAACAGTCCAGCCAATAGCCAGGCAGCACAGCTTTATCAGGAAAACA
AACGAGAATATGAGAAAAGAGTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAATAGACAACTGGTCTGTTAATCTTTTTCATCA
TTGTTGTGTATAATTTACCTCTCATTAGAAAGGCTAACAAATTTTAAGTGCCACAGGTTTTAAGGATTCTGCAGAAAAAAAAGAAAAAAG
TCCTTCAGTTTAGAACCTACAAAAGCTTGTGTATCTTGATTAATGTACTTTTTATTGCATGGTGTGAACTAAGTTATTGCTGCATAAATT
TGTAATATATCCTGTTTGTATTTTTTTCCAAGTGTATAATGTTGGTGTGGAGTTTTCATGACAGAATATACACATTTTGTAAATCTGTAC
TTTTTTCAAATATTGAATGCCTTATTTTTGAATTCTTTAGATTTTTAAATTGGAGAAAAGCACTTAAAGTTTTTTATATATGAATATTAC
ATGTAAAGCTGTTAAAATACATAACTTCAGTGCAAGAGACTTTGTCACTTATTTCCTTATGTGTGTAGGAGGGGTTAATAAGTCTCTAGC
TCTCCATCTATTGATAGTTTCATTTACAATTTCAAAAGAACATTCTTATATTTTATCAAGGAAGTCTTCAAATTTGATTCTAAATAGCGA
TTATAATCTCCAACTTTATTTTGAATGTACCTCTATTAGTTTCAATTGAGTAATTCTAGACATAACTGGTTTGACTCTGTCCAACTCTGT
ATTTAGGCCATTTGTTACAGTTTCTTCATGCATTACTTACTGTTAAAACTGTACCTTTTGCGATTTCACAGTTGGCACTTCTGCCATGAG
CAGAGAACTGATGCGACTTGTTTTGCTGCTTGGTAGCACTTTAAAAAATTTTTTGATTAATGAAGAAAGTAAAACCATAAACATTTGCCA
AAAATTCATGCCCCAGTATTAGCAATGAATTAGTTGCATTGGTTTGAGAAAGGCACATATTGGAGGGAAATCTTGGTGTAACTTAAATAT
TTGAAAATTACCTTTAATGCAATGCATATCTGTTTATTCTGGGAAATGTTTTAATGCCAGGGCCTGCTGAGTTGCTTCTTCTTGTGGAGA
TTTTTTTTTTAATCTCCTGAGTTGTATAAAAGTTGTACTGCATCTTAGTTTACTGGATAAATTTAAAACACAGTATTGTAGAAAGCTAAT
ACAAAACTATCCTATGCCTTCAAATAGTATAGAAAATGGAAAATATACAAGTAAATTCTGTTGAACCACCTGTGTAGTCTCTCTAGTAGT
TAAAACAGCTATTTTAGTAACCCCAAGAGTTTCTTCTCATATCCATAAAATTGGATTACAGTATGGCAATATCTACAGCTTCTATTCATT
ATGCAACGTTTAACATTGATTGGATAAATGCTTATAGGCTGGGCCAGGTGGCTCCCACCTGTAGTCCCAGCACTTTGGGAGGCAAAGGCG
GGAGGATCACTTGAGGCCAGGACTTTGAGACCAGCCAGGGCAACATAATAAGACTTTTCTCTACTTTAAATTTTTTAAAAAATTAGTTGG
GCATAGTGGCACTTGCCTGTAGTCTCAGCTACTTAGGAGGCTGAGGTGGCAGAATAGCTTATGCCTAGGAGGTTGAGGCTGCAGTGAGCT

>64797_64797_3_PHF15-UBE2B_PHF15_chr5_133909452_ENST00000395003_UBE2B_chr5_133724016_ENST00000265339_length(amino acids)=647AA_BP=575
MLARSLSLLLAACSRKPARRGGGCTAQGREIAHVGQSCFKEYSAGRLRGAHATTTFGRMEEKRRKYSISSDNSDTTDSHATSTSASRCSK
LPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSSTM
LGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGED
GNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHI
PASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTL
RKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNL
CYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKR

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Fusion Gene PPI Analysis for PHF15-UBE2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF15-UBE2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF15-UBE2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource