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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF20-MROH8 (FusionGDB2 ID:64823)

Fusion Gene Summary for PHF20-MROH8

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF20-MROH8
Fusion gene ID: 64823
HgeneTgene
Gene symbol

PHF20

MROH8

Gene ID

51230

140699

Gene namePHD finger protein 20maestro heat like repeat family member 8
SynonymsC20orf104|GLEA2|HCA58|NZF|TDRD20A|TZPC20orf131|C20orf132
Cytomap

20q11.22-q11.23

20q11.23

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 20glioma-expressed antigen 2hepatocellular carcinoma-associated antigen 58novel zinc finger proteintranscription factor TZPtudor domain containing 20Aprotein MROH8maestro heat-like repeat-containing protein family member 8
Modification date2020031320200313
UniProtAcc.

Q9H579

Ensembl transtripts involved in fusion geneENST00000439301, ENST00000374012, 
ENST00000481202, 		ENST00000217333, 
ENST00000400441, ENST00000441008, 
ENST00000466091, 
Fusion gene scores* DoF score19 X 17 X 11=355310 X 9 X 7=630
# samples 2910
** MAII scorelog2(29/3553*10)=-3.61491288331629
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF20 [Title/Abstract] AND MROH8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF20(34515801)-MROH8(35800460), # samples:2
Anticipated loss of major functional domain due to fusion event.PHF20-MROH8 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PHF20-MROH8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PHF20-MROH8 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
PHF20-MROH8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHF20

GO:0043981

histone H4-K5 acetylation

20018852

HgenePHF20

GO:0043982

histone H4-K8 acetylation

20018852

HgenePHF20

GO:0043984

histone H4-K16 acetylation

20018852


check buttonFusion gene breakpoints across PHF20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MROH8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3LS-01APHF20chr20

34515801

+MROH8chr20

35800460

-


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Fusion Gene ORF analysis for PHF20-MROH8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000439301ENST00000217333PHF20chr20

34515801

+MROH8chr20

35800460

-
3UTR-3CDSENST00000439301ENST00000400441PHF20chr20

34515801

+MROH8chr20

35800460

-
3UTR-3CDSENST00000439301ENST00000441008PHF20chr20

34515801

+MROH8chr20

35800460

-
3UTR-intronENST00000439301ENST00000466091PHF20chr20

34515801

+MROH8chr20

35800460

-
5CDS-intronENST00000374012ENST00000466091PHF20chr20

34515801

+MROH8chr20

35800460

-
Frame-shiftENST00000374012ENST00000217333PHF20chr20

34515801

+MROH8chr20

35800460

-
In-frameENST00000374012ENST00000400441PHF20chr20

34515801

+MROH8chr20

35800460

-
In-frameENST00000374012ENST00000441008PHF20chr20

34515801

+MROH8chr20

35800460

-
intron-3CDSENST00000481202ENST00000217333PHF20chr20

34515801

+MROH8chr20

35800460

-
intron-3CDSENST00000481202ENST00000400441PHF20chr20

34515801

+MROH8chr20

35800460

-
intron-3CDSENST00000481202ENST00000441008PHF20chr20

34515801

+MROH8chr20

35800460

-
intron-intronENST00000481202ENST00000466091PHF20chr20

34515801

+MROH8chr20

35800460

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374012PHF20chr2034515801+ENST00000441008MROH8chr2035800460-5199223312346941523
ENST00000374012PHF20chr2034515801+ENST00000400441MROH8chr2035800460-5190223312349821619

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374012ENST00000441008PHF20chr2034515801+MROH8chr2035800460-0.0003533640.99964666
ENST00000374012ENST00000400441PHF20chr2034515801+MROH8chr2035800460-0.0004012480.9995988

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Fusion Genomic Features for PHF20-MROH8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHF20-MROH8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:34515801/chr20:35800460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MROH8

Q9H579

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF20chr20:34515801chr20:35800460ENST00000374012+1418162_2217011013.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34515801chr20:35800460ENST00000374012+1418523_5527011013.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34515801chr20:35800460ENST00000439301+1519162_2216791356.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34515801chr20:35800460ENST00000439301+1519523_5526791356.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34515801chr20:35800460ENST00000374012+1418257_2697011013.0DNA bindingNote=A.T hook
HgenePHF20chr20:34515801chr20:35800460ENST00000439301+1519257_2696791356.0DNA bindingNote=A.T hook
HgenePHF20chr20:34515801chr20:35800460ENST00000374012+14184_697011013.0DomainNote=Tudor 1
HgenePHF20chr20:34515801chr20:35800460ENST00000374012+141883_1477011013.0DomainNote=Tudor 2
HgenePHF20chr20:34515801chr20:35800460ENST00000439301+15194_696791356.0DomainNote=Tudor 1
HgenePHF20chr20:34515801chr20:35800460ENST00000439301+151983_1476791356.0DomainNote=Tudor 2
HgenePHF20chr20:34515801chr20:35800460ENST00000374012+1418452_4777011013.0Zinc fingerC2H2-type
HgenePHF20chr20:34515801chr20:35800460ENST00000374012+1418654_7007011013.0Zinc fingerNote=PHD-type
HgenePHF20chr20:34515801chr20:35800460ENST00000439301+1519452_4776791356.0Zinc fingerC2H2-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF20chr20:34515801chr20:35800460ENST00000439301+1519654_7006791356.0Zinc fingerNote=PHD-type


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Fusion Gene Sequence for PHF20-MROH8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64823_64823_1_PHF20-MROH8_PHF20_chr20_34515801_ENST00000374012_MROH8_chr20_35800460_ENST00000400441_length(transcript)=5190nt_BP=2233nt
ATACGCTGGGCGCGTCCCGGGGGTCACGTGGTGCAGAGCACGCAGAGTCCTTCTGTCGGTTGGTCCTGGAGCGGCGCAGCCGGAGTGGGG
CCGTGAGGAGAATAAAGGCAGCCCCGTTGATGACTGAAAATGACAAAGCATCCACCTAACAGACGAGGAATCAGCTTTGAAGTGGGAGCC
CAGTTGGAAGCCCGGGACCGTTTAAAAAACTGGTATCCAGCTCACATAGAAGACATTGACTACGAGGAAGGAAAAGTACTCATCCATTTC
AAGCGTTGGAACCATCGTTATGATGAGTGGTTCTGCTGGGACAGTCCTTATTTACGCCCTTTAGAGAAAATACAGCTGAGGAAAGAGGGC
TTGCATGAAGAGGATGGATCTTCTGAATTTCAAATAAATGAGCAGGTCCTTGCTTGCTGGTCTGATTGTCGTTTTTACCCGGCCAAAGTC
ACTGCTGTTAACAAGGATGGTACTTACACTGTGAAATTTTATGATGGAGTAGTTCAGACTGTCAAACATATTCATGTCAAAGCTTTTTCC
AAAGATCAGAATATTGTGGGTAATGCTAGGCCTAAAGAAACAGATCACAAAAGTCTTTCATCATCTCCTGATAAACGAGAGAAGTTTAAA
GAACAGAGAAAAGCAACAGTGAATGTGAAGAAAGACAAAGAAGATAAACCCTTAAAGACAGAAAAGCGACCCAAGCAGCCTGATAAAGAA
GGAAAGTTAATCTGTTCTGAAAAGGGGAAAGTGTCAGAGAAAAGTCTTCCCAAGAACGAGAAGGAAGACAAGGAAAACATTTCCGAAAAT
GACAGAGAGTATTCTGGAGATGCCCAAGTGGATAAGAAACCTGAAAATGACATTGTGAAGAGTCCACAAGAAAACTTGAGGGAACCCAAA
AGAAAACGAGGCAGACCCCCTTCCATAGCTCCTACTGCTGTGGATTCAAACTCTCAAACTTTGCAACCAATAACATTGGAACTGAGAAGA
AGGAAAATATCAAAAGGATGTGAAGTCCCATTAAAACGTCCTCGGCTTGACAAAAATTCATCCCAGGAAAAGTCAAAAAACTACTCGGAA
AACACTGACAAAGACTTATCGAGGAGACGTTCCTCCAGGCTGTCCACTAATGGGACCCATGAGATCCTAGATCCTGACTTGGTTGTATCA
GATTTGGTTGATACGGATCCTTTGCAAGACACGTTGTCTAGTACCAAGGAATCTGAAGAAGGTCAGTTGAAGTCTGCTTTGGAAGCTGGC
CAGGTCTCATCTGCACTGACTTGCCACTCCTTTGGGGATGGATCCGGGGCTGCAGGCTTGGAGTTGAACTGCCCATCAATGGGAGAAAAC
ACGATGAAAACAGAACCGACTTCTCCCCTTGTGGAATTACAAGAGATTTCGACTGTGGAAGTAACAAATACTTTTAAGAAAACAGATGAT
TTTGGGTCATCTAATGCACCAGCTGTCGACCTAGACCATAAGTTTAGATGCAAAGTTGTGGACTGTTTAAAATTTTTCCGCAAAGCCAAA
CTGTTGCACTATCACATGAAGTATTTCCATGGAATGGAGAAGTCACTGGAGCCAGAAGAGAGCCCGGGAAAGAGGCATGTCCAAACCAGG
GGCCCTTCAGCTTCAGACAAGCCCAGCCAGGAGACCCTGACCAGGAAGCGGGTCTCTGCCAGTTCCCCAACTACAAAAGACAAGGAAAAG
AATAAAGAGAAGAAATTCAAGGAGTTTGTGAGAGTGAAGCCAAAGAAGAAAAAGAAAAAGAAAAAGAAAACCAAACCTGAATGCCCCTGC
AGTGAGGAGATCAGTGACACCTCCCAGGAACCTTCTCCACCCAAGGCATTTGCTGTTACCAGGTGTGGGTCCTCACACAAGCCAGGGGTC
CATATGAGCCCGCAGCTTCATGGCCCAGAATCTGGACACCACAAAGGGAAAGTGAAAGCATTGGAGGAGGATAATTTGAGTGAGTCCTCT
TCTGAGAGCTTTCTCTGGAGTGATGATGAGTATGGCCAAGATGTGGATGTGACCACCAACCCAGATGAGGAACTTGATGGGGATGACCGC
TATGACTTCGAGGTGGTCCGCTGCATCTGTGAGGTCCAGGAGGAAAATGACTTCATGATTCAGTGTGAAGAGTGCCAGTGCTGGCAGCAT
GGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGACTTGGACATCCCTGAC
ATCCCTGGACTCCATTGTGAGCCCCTGTCACATAGCCCCAGACACCTGACCCAACAGGACCCGCTCAGTGAGGCCATTGTTGAGAAACTG
ATCCAGTCCATCCAGAAGGTTTTCAATGGTGAGCTAAAGGGTGAACTTGAAAAGCTGAAATTCCTAGGAGATCTGTCTTCTCTCAGCCAA
GCTTTACCTTATGATGAAACCGCAAAATCATTCATTCACAGCCACATAGCAGACATTGTGCATACCTTAAATGTACTGGTACAAGAGGAA
CGCCCGCATTCTCTGTCCAGTTCCATGCGCCAGGAGGTCTTTGTCACCATCGCTGATCTCAGTTACCAAGATGTCCATTTGCTGTTGGGC
TCTGAAGATCGAGCTGAGTTGTTCAGTCTTACCATCAAGAGTATAATCACTCTGCCCTCTGTAAGGACCCTTACCCAGATACAGGAAATC
ATGCCCAATGGGACCTGCAACACAGAGTGTCTTTACAGGCAGACGTTTCAGGCATTCTCTGAGATGCTCCAGAGTTTGGTGGTAAAAGAC
CCACATTTGGAAAATCTTGACACCATTATTAAGCACTTGGTCCCCTGGTTACAGTCAGTCAAAGACCATGAGCGGGAACGGGCCACGGCC
AGCATGGCTCAAGTTCTGAAGTGCCTATCCAAACATCTCAACTTGAAGCTTCCACTGCGATTCCAAAGACTTGGACACCTAGTGGCTCTG
ATGGCACTGCTCTGTGGGGACCCACAGGAAAAGGTGGCTGAGGAGGCTGCAGAGGGCATTCACTCCCTGCTGCATATCACCCTGAGGCTG
AAGTATATCACTCATGACAAGAAAGATCAGCAAAACTTGAAAAGAGCATTGACAAAATGTCGAGAATTCCTGGAGCTCCACAGCTCTGCC
GCTAAATGCTTCTACAACTGTCCCTTCAGAATTGCCCAGGTCTTTGAAGGTTTTCTTGATTCAAATGAGCTCTGCCAGTTTATAATGACT
ACATTTGATACCCTGAAAACCCTGAAACATCCCTGCATCCAGCGATCAGCAGGAGAATTACTGCTAACTTTGGCAAAAAATACAGAGTCC
CAATTTGAGAAGGTGCCAGAAATTATGGGAGTTATCTGTGCCCAGTTATCCATAATCAGCCAGCCTAGAGTCCGCCAACAAATCATAAAT
ACCGTGAGTTTATTTATATCCAGACCCAAGTACACAGATATAGTGCTCAGCTTCCTTCTGTGTCATCCAGTGCCGTATAACAGGCACCTG
GCTGAGGTGTGGAGAATGCTGTCGGTGGAGCTTCCCAGCACGACCTGGATTCTGTGGAGGCTCCTGAGGAAGCTGCAGAAATGCCATAAT
GAGCCTGCACAGGAGAAGATGGCATATGTGGCTGTGGCTGCAACAGATGCCCTTTATGAGGTGTTTTTGGGAAACAGGCTTCGAGCAGCT
ACGTTCCGACTCTTTCCTCAGCTTCTCATGACACTGCTTATCCAGATTCATCACAGCATCGGCCTCACCATGTCTGATGTCGACATCCCA
AGTGGCCTGTACACAGAACAGGAAGTGCCTTCAGAGGTCACCCCTTTGTGCTTTGCCATGCAGGCTACAAAGACTCTCCTCCTCAGAACA
TGCTGCTTGCAGGAATTCAACATCATGGAAAAGAATAAAGGATGGGCTCTCCTGGGAGGAAAAGATGGCCATCTTCAGGGACTATTTCTC
CTTGCCAACGCATTGCTGGAAAGAAATCAGCTCCTTGCACAGAAGGTCATGTACTTATTAGTCCCTCTTCTTAACCGAGGGAATGATAAA
CATAAACTCACATCTGCAGGCTTTTTTGTGGAGCTTCTCCGGAGTCCAGTGGCCAAGAGACTGCCCAGCATATACTCTGTTGCCCGCTTT
AAAGACTGGCTACAAGATGGAAATCATCTCTTTAGAATTCTCGGCCTGAGGGGACTGTACAATCTTGTTGGACACCAGGAGATGAGAGAA
GACATCAAGAGCCTGTTGCCATACATTGTAGACAGCTTGCGTGAAACCGATGAGAAGATCGTTCTGTCAGCCATCCAGATACTCCTGCAA
CTTGTTAGAACAATGGATTTCACTACCCTGGCTGCCATGATGAGGACCCTGTTCTCCTTATTTGGTGATGTGAGATCTGATGTTCATCGT
TTCTCCGTGACTCTCTTTGGAGCCGCCATAAAGTCTGTAAAAAACCCAGATAAGAAGAGTATAGAGAACCAAGTCCTGGACAGCTTGGTC
CCACTACTTCTGTATTCTCAGGATGAAAATGATGCAGTAGCTGAGGAGAGCAGGCAAGTCCTAACTATATGTGCCCAGTTCCTGAAGTGG
AAGCTGCCCCAAGAAGTGTACTCCAAAGATCCCTGGCACATCAAACCTACTGAAGCAGGAACAATCTGCAGATTCTTTGAAAAAAAGTGC
AAGGGGAAAATTAACATCCTAGAACAAACACTGATGTACTCCAAGAACCCAAAACTTCCCATCAGAAGATCAGCAGTCTTGTTTGTAGGC
CTTTTATCGAAGTACATGGATCACAATGAGCTCAGGAGGATGGGTACTGACTGGATAGAGGACGATCTGAGAGACCTGCTGTGTGACCCT
GAGCCCTCGCTGTGCATCATCGCTTCCCAGACTCTGTTACTAGTCCAGATGGCGAGGGCCGAACCAAAACCTAAGCAGAGAGTGAACTGG
TTGCAGAAGCTCATGGGCAGGTCCTCTGCCTAGAAACACAAGGCAAGCAACATCAGAGACAGAATCTTGCTATGTTGTGCGGCAAGCTAG
TCTTGAACTCATGGCCTCAAGTCATCCTCCTGTGTCAGCCTCCCAAAGTGCTGGGATTACAAGCATGCACCACGGCACCCAGCAGAATTC

>64823_64823_1_PHF20-MROH8_PHF20_chr20_34515801_ENST00000374012_MROH8_chr20_35800460_ENST00000400441_length(amino acids)=1619AA_BP=703
MKMTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQ
INEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKK
DKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAP
TAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDT
LSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDL
DHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVR
VKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKVKALEEDNLSESSSESFLWSDDEY
GQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPDLDIPDIPGLHCEPLSH
SPRHLTQQDPLSEAIVEKLIQSIQKVFNGELKGELEKLKFLGDLSSLSQALPYDETAKSFIHSHIADIVHTLNVLVQEERPHSLSSSMRQ
EVFVTIADLSYQDVHLLLGSEDRAELFSLTIKSIITLPSVRTLTQIQEIMPNGTCNTECLYRQTFQAFSEMLQSLVVKDPHLENLDTIIK
HLVPWLQSVKDHERERATASMAQVLKCLSKHLNLKLPLRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQ
NLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGV
ICAQLSIISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVA
VAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCFAMQATKTLLLRTCCLQEFNIMEK
NKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLF
RILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDEKIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIK
SVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFEKKCKGKINILEQTL

--------------------------------------------------------------
>64823_64823_2_PHF20-MROH8_PHF20_chr20_34515801_ENST00000374012_MROH8_chr20_35800460_ENST00000441008_length(transcript)=5199nt_BP=2233nt
ATACGCTGGGCGCGTCCCGGGGGTCACGTGGTGCAGAGCACGCAGAGTCCTTCTGTCGGTTGGTCCTGGAGCGGCGCAGCCGGAGTGGGG
CCGTGAGGAGAATAAAGGCAGCCCCGTTGATGACTGAAAATGACAAAGCATCCACCTAACAGACGAGGAATCAGCTTTGAAGTGGGAGCC
CAGTTGGAAGCCCGGGACCGTTTAAAAAACTGGTATCCAGCTCACATAGAAGACATTGACTACGAGGAAGGAAAAGTACTCATCCATTTC
AAGCGTTGGAACCATCGTTATGATGAGTGGTTCTGCTGGGACAGTCCTTATTTACGCCCTTTAGAGAAAATACAGCTGAGGAAAGAGGGC
TTGCATGAAGAGGATGGATCTTCTGAATTTCAAATAAATGAGCAGGTCCTTGCTTGCTGGTCTGATTGTCGTTTTTACCCGGCCAAAGTC
ACTGCTGTTAACAAGGATGGTACTTACACTGTGAAATTTTATGATGGAGTAGTTCAGACTGTCAAACATATTCATGTCAAAGCTTTTTCC
AAAGATCAGAATATTGTGGGTAATGCTAGGCCTAAAGAAACAGATCACAAAAGTCTTTCATCATCTCCTGATAAACGAGAGAAGTTTAAA
GAACAGAGAAAAGCAACAGTGAATGTGAAGAAAGACAAAGAAGATAAACCCTTAAAGACAGAAAAGCGACCCAAGCAGCCTGATAAAGAA
GGAAAGTTAATCTGTTCTGAAAAGGGGAAAGTGTCAGAGAAAAGTCTTCCCAAGAACGAGAAGGAAGACAAGGAAAACATTTCCGAAAAT
GACAGAGAGTATTCTGGAGATGCCCAAGTGGATAAGAAACCTGAAAATGACATTGTGAAGAGTCCACAAGAAAACTTGAGGGAACCCAAA
AGAAAACGAGGCAGACCCCCTTCCATAGCTCCTACTGCTGTGGATTCAAACTCTCAAACTTTGCAACCAATAACATTGGAACTGAGAAGA
AGGAAAATATCAAAAGGATGTGAAGTCCCATTAAAACGTCCTCGGCTTGACAAAAATTCATCCCAGGAAAAGTCAAAAAACTACTCGGAA
AACACTGACAAAGACTTATCGAGGAGACGTTCCTCCAGGCTGTCCACTAATGGGACCCATGAGATCCTAGATCCTGACTTGGTTGTATCA
GATTTGGTTGATACGGATCCTTTGCAAGACACGTTGTCTAGTACCAAGGAATCTGAAGAAGGTCAGTTGAAGTCTGCTTTGGAAGCTGGC
CAGGTCTCATCTGCACTGACTTGCCACTCCTTTGGGGATGGATCCGGGGCTGCAGGCTTGGAGTTGAACTGCCCATCAATGGGAGAAAAC
ACGATGAAAACAGAACCGACTTCTCCCCTTGTGGAATTACAAGAGATTTCGACTGTGGAAGTAACAAATACTTTTAAGAAAACAGATGAT
TTTGGGTCATCTAATGCACCAGCTGTCGACCTAGACCATAAGTTTAGATGCAAAGTTGTGGACTGTTTAAAATTTTTCCGCAAAGCCAAA
CTGTTGCACTATCACATGAAGTATTTCCATGGAATGGAGAAGTCACTGGAGCCAGAAGAGAGCCCGGGAAAGAGGCATGTCCAAACCAGG
GGCCCTTCAGCTTCAGACAAGCCCAGCCAGGAGACCCTGACCAGGAAGCGGGTCTCTGCCAGTTCCCCAACTACAAAAGACAAGGAAAAG
AATAAAGAGAAGAAATTCAAGGAGTTTGTGAGAGTGAAGCCAAAGAAGAAAAAGAAAAAGAAAAAGAAAACCAAACCTGAATGCCCCTGC
AGTGAGGAGATCAGTGACACCTCCCAGGAACCTTCTCCACCCAAGGCATTTGCTGTTACCAGGTGTGGGTCCTCACACAAGCCAGGGGTC
CATATGAGCCCGCAGCTTCATGGCCCAGAATCTGGACACCACAAAGGGAAAGTGAAAGCATTGGAGGAGGATAATTTGAGTGAGTCCTCT
TCTGAGAGCTTTCTCTGGAGTGATGATGAGTATGGCCAAGATGTGGATGTGACCACCAACCCAGATGAGGAACTTGATGGGGATGACCGC
TATGACTTCGAGGTGGTCCGCTGCATCTGTGAGGTCCAGGAGGAAAATGACTTCATGATTCAGTGTGAAGAGTGCCAGTGCTGGCAGCAT
GGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGACTTGGACATCCCTGAC
ATCCCTGGACTCCATTGTGAGCCCCTGTCACATAGCCCCAGACACCTGACCCAACAGGACCCGCTCAGTGAGGCCATTGTTGAGAAACTG
ATCCAGTCCATCCAGAAGGTTTTCAATGGTGAGCTAAAGGGTGAACTTGAAAAGCTGAAATTCCTAGGAGATCTGTCTTCTCTCAGCCAA
GCTTTACCTTATGATGAAACCGCAAAATCATTCATTCACAGCCACATAGCAGACATTGTGCATACCTTAAATGTACTGGTACAAGAGGAA
CGCCCGCATTCTCTGTCCAGTTCCATGCGCCAGGAGGTCTTTGTCACCATCGCTGATCTCAGTTACCAAGATGTCCATTTGCTGTTGGGC
TCTGAAGATCGAGCTGAGTTGTTCAGTCTTACCATCAAGAGTATAATCACTCTGCCCTCTGTAAGGACCCTTACCCAGATACAGGAAATC
ATGCCCAATGGGACCTGCAACACAGAGTGTCTTTACAGGCAGACGTTTCAGGCATTCTCTGAGATGCTCCAGAGTTTGGTGGTAAAAGAC
CCACATTTGGAAAATCTTGACACCATTATTAAGCACTTGGTCCCCTGGTTACAGTCAGTCAAAGACCATGAGCGGGAACGGGCCACGGCC
AGCATGGCTCAAGTTCTGAAGTGCCTATCCAAACATCTCAACTTGAAGCTTCCACTGCGATTCCAAAGACTTGGACACCTAGTGGCTCTG
ATGGCACTGCTCTGTGGGGACCCACAGGAAAAGGTGGCTGAGGAGGCTGCAGAGGGCATTCACTCCCTGCTGCATATCACCCTGAGGCTG
AAGTATATCACTCATGACAAGAAAGATCAGCAAAACTTGAAAAGAGCATTGACAAAATGTCGAGAATTCCTGGAGCTCCACAGCTCTGCC
GCTAAATGCTTCTACAACTGTCCCTTCAGAATTGCCCAGGTCTTTGAAGGTTTTCTTGATTCAAATGAGCTCTGCCAGTTTATAATGACT
ACATTTGATACCCTGAAAACCCTGAAACATCCCTGCATCCAGCGATCAGCAGGAGAATTACTGCTAACTTTGGCAAAAAATACAGAGTCC
CAATTTGAGAAGGTGCCAGAAATTATGGGAGTTATCTGTGCCCAGTTATCCATAATCAGCCAGCCTAGAGTCCGCCAACAAATCATAAAT
ACCGTGAGTTTATTTATATCCAGACCCAAGTACACAGATATAGTGCTCAGCTTCCTTCTGTGTCATCCAGTGCCGTATAACAGGCACCTG
GCTGAGGTGTGGAGAATGCTGTCGGTGGAGCTTCCCAGCACGACCTGGATTCTGTGGAGGCTCCTGAGGAAGCTGCAGAAATGCCATAAT
GAGCCTGCACAGGAGAAGATGGCATATGTGGCTGTGGCTGCAACAGATGCCCTTTATGAGGTGTTTTTGGGAAACAGGCTTCGAGCAGCT
ACGTTCCGACTCTTTCCTCAGCTTCTCATGACACTGCTTATCCAGATTCATCACAGCATCGGCCTCACCATGTCTGATGTCGACATCCCA
AGTGGCCTGTACACAGAACAGGAAGTGCCTTCAGAGGTCACCCCTTTGTGCTTTGCCATGCAGGCTACAAAGACTCTCCTCCTCAGAACA
TGCTGCTTGCAGGAATTCAACATCATGGAAAAGAATAAAGGATGGGCTCTCCTGGGAGGAAAAGATGGCCATCTTCAGGGACTATTTCTC
CTTGCCAACGCATTGCTGGAAAGAAATCAGCTCCTTGCACAGAAGGTCATGTACTTATTAGTCCCTCTTCTTAACCGAGGGAATGATAAA
CATAAACTCACATCTGCAGGCTTTTTTGTGGAGCTTCTCCGGAGTCCAGTGGCCAAGAGACTGCCCAGCATATACTCTGTTGCCCGCTTT
AAAGACTGGCTACAAGATGGAAATCATCTCTTTAGAATTCTCGGCCTGAGGGGACTGTACAATCTTGTTGGACACCAGGAGATGAGAGAA
GACATCAAGAGCCTGTTGCCATACATTGTAGACAGCTTGCGTGAAACCGATGAGAAGATCGTTCTGTCAGCCATCCAGATACTCCTGCAA
CTTGTTAGAACAATGGATTTCACTACCCTGGCTGCCATGATGAGGACCCTGTTCTCCTTATTTGGTGATGTGAGATCTGATGTTCATCGT
TTCTCCGTGACTCTCTTTGGAGCCGCCATAAAGTCTGTAAAAAACCCAGATAAGAAGAGTATAGAGAACCAAGTCCTGGACAGCTTGGTC
CCACTACTTCTGTATTCTCAGGATGAAAATGATGCAGTAGCTGAGGAGAGCAGGCAAGTCCTAACTATATGTGCCCAGTTCCTGAAGTGG
AAGCTGCCCCAAGAAGTGTACTCCAAAGATCCCTGGCACATCAAACCTACTGAAGCAGGAACAATCTGCAGATTCTTTGGAAAAAAAGTG
CAAGGGGAAAATTAACATCCTAGAACAAACACTGATGTACTCCAAGAACCCAAAACTTCCCATCAGAAGATCAGCAGTCTTGTTTGTAGG
CCTTTTATCGAAGTACATGGATCACAATGAGCTCAGGAGGATGGGTACTGACTGGATAGAGGACGATCTGAGAGACCTGCTGTGTGACCC
TGAGCCCTCGCTGTGCATCATCGCTTCCCAGACTCTGTTACTAGTCCAGATGGCGAGGGCCGAACCAAAACCTAAGCAGAGAGTGAACTG
GTTGCAGAAGCTCATGGGCAGGTCCTCTGCCTAGAAACACAAGGCAAGCAACATCAGAGACAGAATCTTGCTATGTTGTGCGGCAAGCTA
GTCTTGAACTCATGGCCTCAAGTCATCCTCCTGTGTCAGCCTCCCAAAGTGCTGGGATTACAAGCATGCACCACGGCACCCAGCAGAATT

>64823_64823_2_PHF20-MROH8_PHF20_chr20_34515801_ENST00000374012_MROH8_chr20_35800460_ENST00000441008_length(amino acids)=1523AA_BP=703
MKMTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQ
INEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKK
DKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAP
TAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDT
LSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDL
DHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVR
VKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKVKALEEDNLSESSSESFLWSDDEY
GQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPDLDIPDIPGLHCEPLSH
SPRHLTQQDPLSEAIVEKLIQSIQKVFNGELKGELEKLKFLGDLSSLSQALPYDETAKSFIHSHIADIVHTLNVLVQEERPHSLSSSMRQ
EVFVTIADLSYQDVHLLLGSEDRAELFSLTIKSIITLPSVRTLTQIQEIMPNGTCNTECLYRQTFQAFSEMLQSLVVKDPHLENLDTIIK
HLVPWLQSVKDHERERATASMAQVLKCLSKHLNLKLPLRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQ
NLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGV
ICAQLSIISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVA
VAATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCFAMQATKTLLLRTCCLQEFNIMEK
NKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLF
RILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDEKIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIK

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Fusion Gene PPI Analysis for PHF20-MROH8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF20-MROH8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF20-MROH8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource