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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF20-RPN2 (FusionGDB2 ID:64825)

Fusion Gene Summary for PHF20-RPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF20-RPN2
Fusion gene ID: 64825
HgeneTgene
Gene symbol

PHF20

RPN2

Gene ID

51230

6185

Gene namePHD finger protein 20ribophorin II
SynonymsC20orf104|GLEA2|HCA58|NZF|TDRD20A|TZPRIBIIR|RPN-II|RPNII|SWP1
Cytomap

20q11.22-q11.23

20q11.23

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 20glioma-expressed antigen 2hepatocellular carcinoma-associated antigen 58novel zinc finger proteintranscription factor TZPtudor domain containing 20Adolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunitoligosaccharyltransferase complex subunit (non-catalytic)ribophorin-2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000439301, ENST00000374012, 
ENST00000481202, 
ENST00000237530, 
ENST00000373622, ENST00000470352, 
Fusion gene scores* DoF score19 X 17 X 11=355312 X 13 X 9=1404
# samples 2917
** MAII scorelog2(29/3553*10)=-3.61491288331629
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/1404*10)=-3.04593628416686
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF20 [Title/Abstract] AND RPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF20(34528969)-RPN2(35812583), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHF20

GO:0043981

histone H4-K5 acetylation

20018852

HgenePHF20

GO:0043982

histone H4-K8 acetylation

20018852

HgenePHF20

GO:0043984

histone H4-K16 acetylation

20018852


check buttonFusion gene breakpoints across PHF20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A079-01APHF20chr20

34528969

-RPN2chr20

35812583

+
ChimerDB4BRCATCGA-A8-A079-01APHF20chr20

34528969

+RPN2chr20

35812583

+
ChimerDB4BRCATCGA-A8-A079PHF20chr20

34528969

+RPN2chr20

35812582

+


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Fusion Gene ORF analysis for PHF20-RPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000439301ENST00000237530PHF20chr20

34528969

+RPN2chr20

35812583

+
3UTR-3CDSENST00000439301ENST00000237530PHF20chr20

34528969

+RPN2chr20

35812582

+
3UTR-3CDSENST00000439301ENST00000373622PHF20chr20

34528969

+RPN2chr20

35812583

+
3UTR-3CDSENST00000439301ENST00000373622PHF20chr20

34528969

+RPN2chr20

35812582

+
3UTR-intronENST00000439301ENST00000470352PHF20chr20

34528969

+RPN2chr20

35812583

+
3UTR-intronENST00000439301ENST00000470352PHF20chr20

34528969

+RPN2chr20

35812582

+
5CDS-intronENST00000374012ENST00000470352PHF20chr20

34528969

+RPN2chr20

35812583

+
5CDS-intronENST00000374012ENST00000470352PHF20chr20

34528969

+RPN2chr20

35812582

+
In-frameENST00000374012ENST00000237530PHF20chr20

34528969

+RPN2chr20

35812583

+
In-frameENST00000374012ENST00000237530PHF20chr20

34528969

+RPN2chr20

35812582

+
In-frameENST00000374012ENST00000373622PHF20chr20

34528969

+RPN2chr20

35812583

+
In-frameENST00000374012ENST00000373622PHF20chr20

34528969

+RPN2chr20

35812582

+
intron-3CDSENST00000481202ENST00000237530PHF20chr20

34528969

+RPN2chr20

35812583

+
intron-3CDSENST00000481202ENST00000237530PHF20chr20

34528969

+RPN2chr20

35812582

+
intron-3CDSENST00000481202ENST00000373622PHF20chr20

34528969

+RPN2chr20

35812583

+
intron-3CDSENST00000481202ENST00000373622PHF20chr20

34528969

+RPN2chr20

35812582

+
intron-intronENST00000481202ENST00000470352PHF20chr20

34528969

+RPN2chr20

35812583

+
intron-intronENST00000481202ENST00000470352PHF20chr20

34528969

+RPN2chr20

35812582

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000374012PHF20chr2034528969+ENST00000237530RPN2chr2035812583+5212302512349071594
ENST00000374012PHF20chr2034528969+ENST00000373622RPN2chr2035812583+5164302512348591578
ENST00000374012PHF20chr2034528969+ENST00000237530RPN2chr2035812582+5212302512349071594
ENST00000374012PHF20chr2034528969+ENST00000373622RPN2chr2035812582+5164302512348591578

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374012ENST00000237530PHF20chr2034528969+RPN2chr2035812583+0.0005039380.9994961
ENST00000374012ENST00000373622PHF20chr2034528969+RPN2chr2035812583+0.0005101630.9994898
ENST00000374012ENST00000237530PHF20chr2034528969+RPN2chr2035812582+0.0005039380.9994961
ENST00000374012ENST00000373622PHF20chr2034528969+RPN2chr2035812582+0.0005101630.9994898

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Fusion Genomic Features for PHF20-RPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PHF20chr2034528969+RPN2chr2035812582+1.68E-060.99999833
PHF20chr2034528969+RPN2chr2035812582+1.68E-060.99999833
PHF20chr2034528969+RPN2chr2035812582+1.68E-060.99999833
PHF20chr2034528969+RPN2chr2035812582+1.68E-060.99999833

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PHF20-RPN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:34528969/chr20:35812583)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF20chr20:34528969chr20:35812582ENST00000374012+1718162_2219651013.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34528969chr20:35812582ENST00000374012+1718523_5529651013.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34528969chr20:35812582ENST00000439301+1819162_2219431356.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34528969chr20:35812582ENST00000439301+1819523_5529431356.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34528969chr20:35812583ENST00000374012+1718162_2219651013.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34528969chr20:35812583ENST00000374012+1718523_5529651013.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34528969chr20:35812583ENST00000439301+1819162_2219431356.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34528969chr20:35812583ENST00000439301+1819523_5529431356.0Compositional biasNote=Lys-rich
HgenePHF20chr20:34528969chr20:35812582ENST00000374012+1718257_2699651013.0DNA bindingNote=A.T hook
HgenePHF20chr20:34528969chr20:35812582ENST00000439301+1819257_2699431356.0DNA bindingNote=A.T hook
HgenePHF20chr20:34528969chr20:35812583ENST00000374012+1718257_2699651013.0DNA bindingNote=A.T hook
HgenePHF20chr20:34528969chr20:35812583ENST00000439301+1819257_2699431356.0DNA bindingNote=A.T hook
HgenePHF20chr20:34528969chr20:35812582ENST00000374012+17184_699651013.0DomainNote=Tudor 1
HgenePHF20chr20:34528969chr20:35812582ENST00000374012+171883_1479651013.0DomainNote=Tudor 2
HgenePHF20chr20:34528969chr20:35812582ENST00000439301+18194_699431356.0DomainNote=Tudor 1
HgenePHF20chr20:34528969chr20:35812582ENST00000439301+181983_1479431356.0DomainNote=Tudor 2
HgenePHF20chr20:34528969chr20:35812583ENST00000374012+17184_699651013.0DomainNote=Tudor 1
HgenePHF20chr20:34528969chr20:35812583ENST00000374012+171883_1479651013.0DomainNote=Tudor 2
HgenePHF20chr20:34528969chr20:35812583ENST00000439301+18194_699431356.0DomainNote=Tudor 1
HgenePHF20chr20:34528969chr20:35812583ENST00000439301+181983_1479431356.0DomainNote=Tudor 2
HgenePHF20chr20:34528969chr20:35812582ENST00000374012+1718452_4779651013.0Zinc fingerC2H2-type
HgenePHF20chr20:34528969chr20:35812582ENST00000374012+1718654_7009651013.0Zinc fingerNote=PHD-type
HgenePHF20chr20:34528969chr20:35812582ENST00000439301+1819452_4779431356.0Zinc fingerC2H2-type
HgenePHF20chr20:34528969chr20:35812582ENST00000439301+1819654_7009431356.0Zinc fingerNote=PHD-type
HgenePHF20chr20:34528969chr20:35812583ENST00000374012+1718452_4779651013.0Zinc fingerC2H2-type
HgenePHF20chr20:34528969chr20:35812583ENST00000374012+1718654_7009651013.0Zinc fingerNote=PHD-type
HgenePHF20chr20:34528969chr20:35812583ENST00000439301+1819452_4779431356.0Zinc fingerC2H2-type
HgenePHF20chr20:34528969chr20:35812583ENST00000439301+1819654_7009431356.0Zinc fingerNote=PHD-type
TgeneRPN2chr20:34528969chr20:35812582ENST0000023753001723_5404632.0Topological domainLumenal
TgeneRPN2chr20:34528969chr20:35812582ENST00000237530017562_5714632.0Topological domainCytoplasmic
TgeneRPN2chr20:34528969chr20:35812582ENST00000237530017593_5964632.0Topological domainLumenal
TgeneRPN2chr20:34528969chr20:35812582ENST00000237530017618_6314632.0Topological domainCytoplasmic
TgeneRPN2chr20:34528969chr20:35812582ENST0000037362201723_5404616.0Topological domainLumenal
TgeneRPN2chr20:34528969chr20:35812582ENST00000373622017562_5714616.0Topological domainCytoplasmic
TgeneRPN2chr20:34528969chr20:35812582ENST00000373622017593_5964616.0Topological domainLumenal
TgeneRPN2chr20:34528969chr20:35812582ENST00000373622017618_6314616.0Topological domainCytoplasmic
TgeneRPN2chr20:34528969chr20:35812583ENST0000023753001723_5404632.0Topological domainLumenal
TgeneRPN2chr20:34528969chr20:35812583ENST00000237530017562_5714632.0Topological domainCytoplasmic
TgeneRPN2chr20:34528969chr20:35812583ENST00000237530017593_5964632.0Topological domainLumenal
TgeneRPN2chr20:34528969chr20:35812583ENST00000237530017618_6314632.0Topological domainCytoplasmic
TgeneRPN2chr20:34528969chr20:35812583ENST0000037362201723_5404616.0Topological domainLumenal
TgeneRPN2chr20:34528969chr20:35812583ENST00000373622017562_5714616.0Topological domainCytoplasmic
TgeneRPN2chr20:34528969chr20:35812583ENST00000373622017593_5964616.0Topological domainLumenal
TgeneRPN2chr20:34528969chr20:35812583ENST00000373622017618_6314616.0Topological domainCytoplasmic
TgeneRPN2chr20:34528969chr20:35812582ENST00000237530017541_5614632.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812582ENST00000237530017572_5924632.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812582ENST00000237530017597_6174632.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812582ENST00000373622017541_5614616.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812582ENST00000373622017572_5924616.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812582ENST00000373622017597_6174616.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812583ENST00000237530017541_5614632.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812583ENST00000237530017572_5924632.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812583ENST00000237530017597_6174632.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812583ENST00000373622017541_5614616.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812583ENST00000373622017572_5924616.0TransmembraneHelical
TgeneRPN2chr20:34528969chr20:35812583ENST00000373622017597_6174616.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PHF20-RPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64825_64825_1_PHF20-RPN2_PHF20_chr20_34528969_ENST00000374012_RPN2_chr20_35812582_ENST00000237530_length(transcript)=5212nt_BP=3025nt
ATACGCTGGGCGCGTCCCGGGGGTCACGTGGTGCAGAGCACGCAGAGTCCTTCTGTCGGTTGGTCCTGGAGCGGCGCAGCCGGAGTGGGG
CCGTGAGGAGAATAAAGGCAGCCCCGTTGATGACTGAAAATGACAAAGCATCCACCTAACAGACGAGGAATCAGCTTTGAAGTGGGAGCC
CAGTTGGAAGCCCGGGACCGTTTAAAAAACTGGTATCCAGCTCACATAGAAGACATTGACTACGAGGAAGGAAAAGTACTCATCCATTTC
AAGCGTTGGAACCATCGTTATGATGAGTGGTTCTGCTGGGACAGTCCTTATTTACGCCCTTTAGAGAAAATACAGCTGAGGAAAGAGGGC
TTGCATGAAGAGGATGGATCTTCTGAATTTCAAATAAATGAGCAGGTCCTTGCTTGCTGGTCTGATTGTCGTTTTTACCCGGCCAAAGTC
ACTGCTGTTAACAAGGATGGTACTTACACTGTGAAATTTTATGATGGAGTAGTTCAGACTGTCAAACATATTCATGTCAAAGCTTTTTCC
AAAGATCAGAATATTGTGGGTAATGCTAGGCCTAAAGAAACAGATCACAAAAGTCTTTCATCATCTCCTGATAAACGAGAGAAGTTTAAA
GAACAGAGAAAAGCAACAGTGAATGTGAAGAAAGACAAAGAAGATAAACCCTTAAAGACAGAAAAGCGACCCAAGCAGCCTGATAAAGAA
GGAAAGTTAATCTGTTCTGAAAAGGGGAAAGTGTCAGAGAAAAGTCTTCCCAAGAACGAGAAGGAAGACAAGGAAAACATTTCCGAAAAT
GACAGAGAGTATTCTGGAGATGCCCAAGTGGATAAGAAACCTGAAAATGACATTGTGAAGAGTCCACAAGAAAACTTGAGGGAACCCAAA
AGAAAACGAGGCAGACCCCCTTCCATAGCTCCTACTGCTGTGGATTCAAACTCTCAAACTTTGCAACCAATAACATTGGAACTGAGAAGA
AGGAAAATATCAAAAGGATGTGAAGTCCCATTAAAACGTCCTCGGCTTGACAAAAATTCATCCCAGGAAAAGTCAAAAAACTACTCGGAA
AACACTGACAAAGACTTATCGAGGAGACGTTCCTCCAGGCTGTCCACTAATGGGACCCATGAGATCCTAGATCCTGACTTGGTTGTATCA
GATTTGGTTGATACGGATCCTTTGCAAGACACGTTGTCTAGTACCAAGGAATCTGAAGAAGGTCAGTTGAAGTCTGCTTTGGAAGCTGGC
CAGGTCTCATCTGCACTGACTTGCCACTCCTTTGGGGATGGATCCGGGGCTGCAGGCTTGGAGTTGAACTGCCCATCAATGGGAGAAAAC
ACGATGAAAACAGAACCGACTTCTCCCCTTGTGGAATTACAAGAGATTTCGACTGTGGAAGTAACAAATACTTTTAAGAAAACAGATGAT
TTTGGGTCATCTAATGCACCAGCTGTCGACCTAGACCATAAGTTTAGATGCAAAGTTGTGGACTGTTTAAAATTTTTCCGCAAAGCCAAA
CTGTTGCACTATCACATGAAGTATTTCCATGGAATGGAGAAGTCACTGGAGCCAGAAGAGAGCCCGGGAAAGAGGCATGTCCAAACCAGG
GGCCCTTCAGCTTCAGACAAGCCCAGCCAGGAGACCCTGACCAGGAAGCGGGTCTCTGCCAGTTCCCCAACTACAAAAGACAAGGAAAAG
AATAAAGAGAAGAAATTCAAGGAGTTTGTGAGAGTGAAGCCAAAGAAGAAAAAGAAAAAGAAAAAGAAAACCAAACCTGAATGCCCCTGC
AGTGAGGAGATCAGTGACACCTCCCAGGAACCTTCTCCACCCAAGGCATTTGCTGTTACCAGGTGTGGGTCCTCACACAAGCCAGGGGTC
CATATGAGCCCGCAGCTTCATGGCCCAGAATCTGGACACCACAAAGGGAAAGTGAAAGCATTGGAGGAGGATAATTTGAGTGAGTCCTCT
TCTGAGAGCTTTCTCTGGAGTGATGATGAGTATGGCCAAGATGTGGATGTGACCACCAACCCAGATGAGGAACTTGATGGGGATGACCGC
TATGACTTCGAGGTGGTCCGCTGCATCTGTGAGGTCCAGGAGGAAAATGACTTCATGATTCAGTGTGAAGAGTGCCAGTGCTGGCAGCAT
GGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGCTTC
AAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCCAAG
AAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTGCAA
AGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCTGTC
ACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTGCCG
CGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTGGTG
GAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCTCTA
GACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAAGAA
GCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTGGAA
TCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATC
ATAGCCAGCACCTGGGCTCTGACGCCCACTCACTACCTCACCAAGCATGACGTGGAGAGACTAAAAGCCTCGCTGGATCGCCCTTTCACA
AATTTGGAATCTGCCTTCTACTCCATCGTGGGACTCAGCAGCCTTGGTGCTCAGGTGCCAGATGCAAAGAAAGCATGTACCTACATCAGA
TCTAACCTTGATCCCAGCAATGTGGATTCCCTCTTCTACGCTGCCCAGGCCAGCCAGGCCCTCTCAGGATGTGAGATCTCTATTTCAAAT
GAGACCAAAGATCTGCTTCTGGCAGCTGTCAGTGAGGACTCATCTGTTACCCAGATCTACCATGCAGTTGCAGCTCTAAGTGGCTTTGGC
CTTCCCTTGGCATCCCAAGAAGCACTCAGTGCCCTTACTGCTCGTCTCAGCAAGGAGGAGACTGTGCTGGCAACAGTCCAGGCTCTGCAG
ACAGCATCCCACCTGTCCCAGCAGGCTGACCTGAGGAGCATCGTGGAGGAGATTGAGGACCTTGTTGCTCGCCTGGATGAACTCGGGGGC
GTGTATCTCCAGTTTGAAGAAGGACTGGAAACAACAGCGTTATTTGTGGCTGCCACCTACAAGCTCATGGATCATGTGGGGACTGAGCCA
TCCATTAAGGAGGATCAGGTCATCCAGCTGATGAACGCGATCTTCAGCAAGAAGAACTTTGAGTCCCTCTCCGAAGCCTTCAGCGTGGCC
TCTGCAGCTGCTGTGCTCTCGCATAATCGCTACCACGTGCCAGTTGTGGTTGTGCCTGAGGGCTCTGCTTCCGACACTCATGAACAGGCT
ATCTTGCGGTTGCAAGTCACCAATGTTCTGTCTCAGCCTCTGACTCAGGCCACTGTTAAACTAGAACATGCTAAATCTGTTGCTTCCAGA
GCCACTGTCCTCCAGAAGACATCCTTCACCCCTGTAGGGGATGTTTTTGAACTAAATTTCATGAACGTCAAATTTTCCAGTGGTTATTAT
GACTTCCTTGTCGAAGTTGAAGGTGACAACCGGTATATTGCAAATACCGTAGAGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACA
AATGTTGATCTTTCCACCGTGGATAAGGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTC
ATCGCAGACAGCCACCAGAACTTCGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTC
CGACTCCATAACCAGAAGACTGGCCAGGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCT
GAAAGAAAGATTGAATTTGACTCTGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGG
AATGTGGCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATT
CAGCACCTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTC
TTCGCTCTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATG
CTGGGACTCATGTATGTCTACTGGACTCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCT
GGCAATCGGATGCTGGCCCAGCAGGCAGTCAAGAGAACAGCACATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGA
AAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATA
CTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTG

>64825_64825_1_PHF20-RPN2_PHF20_chr20_34528969_ENST00000374012_RPN2_chr20_35812582_ENST00000237530_length(amino acids)=1594AA_BP=967
MKMTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQ
INEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKK
DKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAP
TAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDT
LSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDL
DHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVR
VKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKVKALEEDNLSESSSESFLWSDDEY
GQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSR
GHMHGLAFLEENYSHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPS
YRTLNGAVEKPRPLALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDP
KPGSPKVKEYVSKKALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDGSSTVFLLALTIIASTWALTPTH
YLTKHDVERLKASLDRPFTNLESAFYSIVGLSSLGAQVPDAKKACTYIRSNLDPSNVDSLFYAAQASQALSGCEISISNETKDLLLAAVS
EDSSVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLATVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLET
TALFVAATYKLMDHVGTEPSIKEDQVIQLMNAIFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLS
QPLTQATVKLEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEVEGDNRYIANTVELRVKISTEVGITNVDLSTVDKDQ
SIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASG
TYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANV

--------------------------------------------------------------
>64825_64825_2_PHF20-RPN2_PHF20_chr20_34528969_ENST00000374012_RPN2_chr20_35812582_ENST00000373622_length(transcript)=5164nt_BP=3025nt
ATACGCTGGGCGCGTCCCGGGGGTCACGTGGTGCAGAGCACGCAGAGTCCTTCTGTCGGTTGGTCCTGGAGCGGCGCAGCCGGAGTGGGG
CCGTGAGGAGAATAAAGGCAGCCCCGTTGATGACTGAAAATGACAAAGCATCCACCTAACAGACGAGGAATCAGCTTTGAAGTGGGAGCC
CAGTTGGAAGCCCGGGACCGTTTAAAAAACTGGTATCCAGCTCACATAGAAGACATTGACTACGAGGAAGGAAAAGTACTCATCCATTTC
AAGCGTTGGAACCATCGTTATGATGAGTGGTTCTGCTGGGACAGTCCTTATTTACGCCCTTTAGAGAAAATACAGCTGAGGAAAGAGGGC
TTGCATGAAGAGGATGGATCTTCTGAATTTCAAATAAATGAGCAGGTCCTTGCTTGCTGGTCTGATTGTCGTTTTTACCCGGCCAAAGTC
ACTGCTGTTAACAAGGATGGTACTTACACTGTGAAATTTTATGATGGAGTAGTTCAGACTGTCAAACATATTCATGTCAAAGCTTTTTCC
AAAGATCAGAATATTGTGGGTAATGCTAGGCCTAAAGAAACAGATCACAAAAGTCTTTCATCATCTCCTGATAAACGAGAGAAGTTTAAA
GAACAGAGAAAAGCAACAGTGAATGTGAAGAAAGACAAAGAAGATAAACCCTTAAAGACAGAAAAGCGACCCAAGCAGCCTGATAAAGAA
GGAAAGTTAATCTGTTCTGAAAAGGGGAAAGTGTCAGAGAAAAGTCTTCCCAAGAACGAGAAGGAAGACAAGGAAAACATTTCCGAAAAT
GACAGAGAGTATTCTGGAGATGCCCAAGTGGATAAGAAACCTGAAAATGACATTGTGAAGAGTCCACAAGAAAACTTGAGGGAACCCAAA
AGAAAACGAGGCAGACCCCCTTCCATAGCTCCTACTGCTGTGGATTCAAACTCTCAAACTTTGCAACCAATAACATTGGAACTGAGAAGA
AGGAAAATATCAAAAGGATGTGAAGTCCCATTAAAACGTCCTCGGCTTGACAAAAATTCATCCCAGGAAAAGTCAAAAAACTACTCGGAA
AACACTGACAAAGACTTATCGAGGAGACGTTCCTCCAGGCTGTCCACTAATGGGACCCATGAGATCCTAGATCCTGACTTGGTTGTATCA
GATTTGGTTGATACGGATCCTTTGCAAGACACGTTGTCTAGTACCAAGGAATCTGAAGAAGGTCAGTTGAAGTCTGCTTTGGAAGCTGGC
CAGGTCTCATCTGCACTGACTTGCCACTCCTTTGGGGATGGATCCGGGGCTGCAGGCTTGGAGTTGAACTGCCCATCAATGGGAGAAAAC
ACGATGAAAACAGAACCGACTTCTCCCCTTGTGGAATTACAAGAGATTTCGACTGTGGAAGTAACAAATACTTTTAAGAAAACAGATGAT
TTTGGGTCATCTAATGCACCAGCTGTCGACCTAGACCATAAGTTTAGATGCAAAGTTGTGGACTGTTTAAAATTTTTCCGCAAAGCCAAA
CTGTTGCACTATCACATGAAGTATTTCCATGGAATGGAGAAGTCACTGGAGCCAGAAGAGAGCCCGGGAAAGAGGCATGTCCAAACCAGG
GGCCCTTCAGCTTCAGACAAGCCCAGCCAGGAGACCCTGACCAGGAAGCGGGTCTCTGCCAGTTCCCCAACTACAAAAGACAAGGAAAAG
AATAAAGAGAAGAAATTCAAGGAGTTTGTGAGAGTGAAGCCAAAGAAGAAAAAGAAAAAGAAAAAGAAAACCAAACCTGAATGCCCCTGC
AGTGAGGAGATCAGTGACACCTCCCAGGAACCTTCTCCACCCAAGGCATTTGCTGTTACCAGGTGTGGGTCCTCACACAAGCCAGGGGTC
CATATGAGCCCGCAGCTTCATGGCCCAGAATCTGGACACCACAAAGGGAAAGTGAAAGCATTGGAGGAGGATAATTTGAGTGAGTCCTCT
TCTGAGAGCTTTCTCTGGAGTGATGATGAGTATGGCCAAGATGTGGATGTGACCACCAACCCAGATGAGGAACTTGATGGGGATGACCGC
TATGACTTCGAGGTGGTCCGCTGCATCTGTGAGGTCCAGGAGGAAAATGACTTCATGATTCAGTGTGAAGAGTGCCAGTGCTGGCAGCAT
GGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGCTTC
AAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCCAAG
AAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTGCAA
AGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCTGTC
ACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTGCCG
CGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTGGTG
GAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCTCTA
GACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAAGAA
GCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTGGAA
TCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATC
ATAGCCAGCACCTGGGCTCTGACGCCCACTCACTACCTCACCAAGCATGACGTGGAGAGACTAAAAGCCTCGCTGGATCGCCCTTTCACA
AATTTGGAATCTGCCTTCTACTCCATCGTGGGACTCAGCAGCCTTGGTGCTCAGGTGCCAGATGCAAAGATCTCTATTTCAAATGAGACC
AAAGATCTGCTTCTGGCAGCTGTCAGTGAGGACTCATCTGTTACCCAGATCTACCATGCAGTTGCAGCTCTAAGTGGCTTTGGCCTTCCC
TTGGCATCCCAAGAAGCACTCAGTGCCCTTACTGCTCGTCTCAGCAAGGAGGAGACTGTGCTGGCAACAGTCCAGGCTCTGCAGACAGCA
TCCCACCTGTCCCAGCAGGCTGACCTGAGGAGCATCGTGGAGGAGATTGAGGACCTTGTTGCTCGCCTGGATGAACTCGGGGGCGTGTAT
CTCCAGTTTGAAGAAGGACTGGAAACAACAGCGTTATTTGTGGCTGCCACCTACAAGCTCATGGATCATGTGGGGACTGAGCCATCCATT
AAGGAGGATCAGGTCATCCAGCTGATGAACGCGATCTTCAGCAAGAAGAACTTTGAGTCCCTCTCCGAAGCCTTCAGCGTGGCCTCTGCA
GCTGCTGTGCTCTCGCATAATCGCTACCACGTGCCAGTTGTGGTTGTGCCTGAGGGCTCTGCTTCCGACACTCATGAACAGGCTATCTTG
CGGTTGCAAGTCACCAATGTTCTGTCTCAGCCTCTGACTCAGGCCACTGTTAAACTAGAACATGCTAAATCTGTTGCTTCCAGAGCCACT
GTCCTCCAGAAGACATCCTTCACCCCTGTAGGGGATGTTTTTGAACTAAATTTCATGAACGTCAAATTTTCCAGTGGTTATTATGACTTC
CTTGTCGAAGTTGAAGGTGACAACCGGTATATTGCAAATACCGTAGAGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTT
GATCTTTCCACCGTGGATAAGGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCA
GACAGCCACCAGAACTTCGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTC
CATAACCAGAAGACTGGCCAGGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGA
AAGATTGAATTTGACTCTGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTG
GCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCAC
CTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCT
CTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGA
CTCATGTATGTCTACTGGACTCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAAT
CGGATGCTGGCCCAGCAGGCAGTCAAGAGGATCGCTGCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAG
TTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAA
AAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGA
GCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTGCTTTTGAAAAGTTGAAATGTGT

>64825_64825_2_PHF20-RPN2_PHF20_chr20_34528969_ENST00000374012_RPN2_chr20_35812582_ENST00000373622_length(amino acids)=1578AA_BP=967
MKMTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQ
INEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKK
DKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAP
TAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDT
LSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDL
DHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVR
VKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKVKALEEDNLSESSSESFLWSDDEY
GQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSR
GHMHGLAFLEENYSHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPS
YRTLNGAVEKPRPLALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDP
KPGSPKVKEYVSKKALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDGSSTVFLLALTIIASTWALTPTH
YLTKHDVERLKASLDRPFTNLESAFYSIVGLSSLGAQVPDAKISISNETKDLLLAAVSEDSSVTQIYHAVAALSGFGLPLASQEALSALT
ARLSKEETVLATVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQLMNA
IFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPLTQATVKLEHAKSVASRATVLQKTSFTPVG
DVFELNFMNVKFSSGYYDFLVEVEGDNRYIANTVELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQ
LVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEE
APSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNM

--------------------------------------------------------------
>64825_64825_3_PHF20-RPN2_PHF20_chr20_34528969_ENST00000374012_RPN2_chr20_35812583_ENST00000237530_length(transcript)=5212nt_BP=3025nt
ATACGCTGGGCGCGTCCCGGGGGTCACGTGGTGCAGAGCACGCAGAGTCCTTCTGTCGGTTGGTCCTGGAGCGGCGCAGCCGGAGTGGGG
CCGTGAGGAGAATAAAGGCAGCCCCGTTGATGACTGAAAATGACAAAGCATCCACCTAACAGACGAGGAATCAGCTTTGAAGTGGGAGCC
CAGTTGGAAGCCCGGGACCGTTTAAAAAACTGGTATCCAGCTCACATAGAAGACATTGACTACGAGGAAGGAAAAGTACTCATCCATTTC
AAGCGTTGGAACCATCGTTATGATGAGTGGTTCTGCTGGGACAGTCCTTATTTACGCCCTTTAGAGAAAATACAGCTGAGGAAAGAGGGC
TTGCATGAAGAGGATGGATCTTCTGAATTTCAAATAAATGAGCAGGTCCTTGCTTGCTGGTCTGATTGTCGTTTTTACCCGGCCAAAGTC
ACTGCTGTTAACAAGGATGGTACTTACACTGTGAAATTTTATGATGGAGTAGTTCAGACTGTCAAACATATTCATGTCAAAGCTTTTTCC
AAAGATCAGAATATTGTGGGTAATGCTAGGCCTAAAGAAACAGATCACAAAAGTCTTTCATCATCTCCTGATAAACGAGAGAAGTTTAAA
GAACAGAGAAAAGCAACAGTGAATGTGAAGAAAGACAAAGAAGATAAACCCTTAAAGACAGAAAAGCGACCCAAGCAGCCTGATAAAGAA
GGAAAGTTAATCTGTTCTGAAAAGGGGAAAGTGTCAGAGAAAAGTCTTCCCAAGAACGAGAAGGAAGACAAGGAAAACATTTCCGAAAAT
GACAGAGAGTATTCTGGAGATGCCCAAGTGGATAAGAAACCTGAAAATGACATTGTGAAGAGTCCACAAGAAAACTTGAGGGAACCCAAA
AGAAAACGAGGCAGACCCCCTTCCATAGCTCCTACTGCTGTGGATTCAAACTCTCAAACTTTGCAACCAATAACATTGGAACTGAGAAGA
AGGAAAATATCAAAAGGATGTGAAGTCCCATTAAAACGTCCTCGGCTTGACAAAAATTCATCCCAGGAAAAGTCAAAAAACTACTCGGAA
AACACTGACAAAGACTTATCGAGGAGACGTTCCTCCAGGCTGTCCACTAATGGGACCCATGAGATCCTAGATCCTGACTTGGTTGTATCA
GATTTGGTTGATACGGATCCTTTGCAAGACACGTTGTCTAGTACCAAGGAATCTGAAGAAGGTCAGTTGAAGTCTGCTTTGGAAGCTGGC
CAGGTCTCATCTGCACTGACTTGCCACTCCTTTGGGGATGGATCCGGGGCTGCAGGCTTGGAGTTGAACTGCCCATCAATGGGAGAAAAC
ACGATGAAAACAGAACCGACTTCTCCCCTTGTGGAATTACAAGAGATTTCGACTGTGGAAGTAACAAATACTTTTAAGAAAACAGATGAT
TTTGGGTCATCTAATGCACCAGCTGTCGACCTAGACCATAAGTTTAGATGCAAAGTTGTGGACTGTTTAAAATTTTTCCGCAAAGCCAAA
CTGTTGCACTATCACATGAAGTATTTCCATGGAATGGAGAAGTCACTGGAGCCAGAAGAGAGCCCGGGAAAGAGGCATGTCCAAACCAGG
GGCCCTTCAGCTTCAGACAAGCCCAGCCAGGAGACCCTGACCAGGAAGCGGGTCTCTGCCAGTTCCCCAACTACAAAAGACAAGGAAAAG
AATAAAGAGAAGAAATTCAAGGAGTTTGTGAGAGTGAAGCCAAAGAAGAAAAAGAAAAAGAAAAAGAAAACCAAACCTGAATGCCCCTGC
AGTGAGGAGATCAGTGACACCTCCCAGGAACCTTCTCCACCCAAGGCATTTGCTGTTACCAGGTGTGGGTCCTCACACAAGCCAGGGGTC
CATATGAGCCCGCAGCTTCATGGCCCAGAATCTGGACACCACAAAGGGAAAGTGAAAGCATTGGAGGAGGATAATTTGAGTGAGTCCTCT
TCTGAGAGCTTTCTCTGGAGTGATGATGAGTATGGCCAAGATGTGGATGTGACCACCAACCCAGATGAGGAACTTGATGGGGATGACCGC
TATGACTTCGAGGTGGTCCGCTGCATCTGTGAGGTCCAGGAGGAAAATGACTTCATGATTCAGTGTGAAGAGTGCCAGTGCTGGCAGCAT
GGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGCTTC
AAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCCAAG
AAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTGCAA
AGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCTGTC
ACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTGCCG
CGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTGGTG
GAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCTCTA
GACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAAGAA
GCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTGGAA
TCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATC
ATAGCCAGCACCTGGGCTCTGACGCCCACTCACTACCTCACCAAGCATGACGTGGAGAGACTAAAAGCCTCGCTGGATCGCCCTTTCACA
AATTTGGAATCTGCCTTCTACTCCATCGTGGGACTCAGCAGCCTTGGTGCTCAGGTGCCAGATGCAAAGAAAGCATGTACCTACATCAGA
TCTAACCTTGATCCCAGCAATGTGGATTCCCTCTTCTACGCTGCCCAGGCCAGCCAGGCCCTCTCAGGATGTGAGATCTCTATTTCAAAT
GAGACCAAAGATCTGCTTCTGGCAGCTGTCAGTGAGGACTCATCTGTTACCCAGATCTACCATGCAGTTGCAGCTCTAAGTGGCTTTGGC
CTTCCCTTGGCATCCCAAGAAGCACTCAGTGCCCTTACTGCTCGTCTCAGCAAGGAGGAGACTGTGCTGGCAACAGTCCAGGCTCTGCAG
ACAGCATCCCACCTGTCCCAGCAGGCTGACCTGAGGAGCATCGTGGAGGAGATTGAGGACCTTGTTGCTCGCCTGGATGAACTCGGGGGC
GTGTATCTCCAGTTTGAAGAAGGACTGGAAACAACAGCGTTATTTGTGGCTGCCACCTACAAGCTCATGGATCATGTGGGGACTGAGCCA
TCCATTAAGGAGGATCAGGTCATCCAGCTGATGAACGCGATCTTCAGCAAGAAGAACTTTGAGTCCCTCTCCGAAGCCTTCAGCGTGGCC
TCTGCAGCTGCTGTGCTCTCGCATAATCGCTACCACGTGCCAGTTGTGGTTGTGCCTGAGGGCTCTGCTTCCGACACTCATGAACAGGCT
ATCTTGCGGTTGCAAGTCACCAATGTTCTGTCTCAGCCTCTGACTCAGGCCACTGTTAAACTAGAACATGCTAAATCTGTTGCTTCCAGA
GCCACTGTCCTCCAGAAGACATCCTTCACCCCTGTAGGGGATGTTTTTGAACTAAATTTCATGAACGTCAAATTTTCCAGTGGTTATTAT
GACTTCCTTGTCGAAGTTGAAGGTGACAACCGGTATATTGCAAATACCGTAGAGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACA
AATGTTGATCTTTCCACCGTGGATAAGGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTC
ATCGCAGACAGCCACCAGAACTTCGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTC
CGACTCCATAACCAGAAGACTGGCCAGGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCT
GAAAGAAAGATTGAATTTGACTCTGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGG
AATGTGGCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATT
CAGCACCTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTC
TTCGCTCTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATG
CTGGGACTCATGTATGTCTACTGGACTCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCT
GGCAATCGGATGCTGGCCCAGCAGGCAGTCAAGAGAACAGCACATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGA
AAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATA
CTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTG

>64825_64825_3_PHF20-RPN2_PHF20_chr20_34528969_ENST00000374012_RPN2_chr20_35812583_ENST00000237530_length(amino acids)=1594AA_BP=967
MKMTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQ
INEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKK
DKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAP
TAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDT
LSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDL
DHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVR
VKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKVKALEEDNLSESSSESFLWSDDEY
GQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSR
GHMHGLAFLEENYSHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPS
YRTLNGAVEKPRPLALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDP
KPGSPKVKEYVSKKALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDGSSTVFLLALTIIASTWALTPTH
YLTKHDVERLKASLDRPFTNLESAFYSIVGLSSLGAQVPDAKKACTYIRSNLDPSNVDSLFYAAQASQALSGCEISISNETKDLLLAAVS
EDSSVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLATVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLET
TALFVAATYKLMDHVGTEPSIKEDQVIQLMNAIFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLS
QPLTQATVKLEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEVEGDNRYIANTVELRVKISTEVGITNVDLSTVDKDQ
SIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASG
TYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANV

--------------------------------------------------------------
>64825_64825_4_PHF20-RPN2_PHF20_chr20_34528969_ENST00000374012_RPN2_chr20_35812583_ENST00000373622_length(transcript)=5164nt_BP=3025nt
ATACGCTGGGCGCGTCCCGGGGGTCACGTGGTGCAGAGCACGCAGAGTCCTTCTGTCGGTTGGTCCTGGAGCGGCGCAGCCGGAGTGGGG
CCGTGAGGAGAATAAAGGCAGCCCCGTTGATGACTGAAAATGACAAAGCATCCACCTAACAGACGAGGAATCAGCTTTGAAGTGGGAGCC
CAGTTGGAAGCCCGGGACCGTTTAAAAAACTGGTATCCAGCTCACATAGAAGACATTGACTACGAGGAAGGAAAAGTACTCATCCATTTC
AAGCGTTGGAACCATCGTTATGATGAGTGGTTCTGCTGGGACAGTCCTTATTTACGCCCTTTAGAGAAAATACAGCTGAGGAAAGAGGGC
TTGCATGAAGAGGATGGATCTTCTGAATTTCAAATAAATGAGCAGGTCCTTGCTTGCTGGTCTGATTGTCGTTTTTACCCGGCCAAAGTC
ACTGCTGTTAACAAGGATGGTACTTACACTGTGAAATTTTATGATGGAGTAGTTCAGACTGTCAAACATATTCATGTCAAAGCTTTTTCC
AAAGATCAGAATATTGTGGGTAATGCTAGGCCTAAAGAAACAGATCACAAAAGTCTTTCATCATCTCCTGATAAACGAGAGAAGTTTAAA
GAACAGAGAAAAGCAACAGTGAATGTGAAGAAAGACAAAGAAGATAAACCCTTAAAGACAGAAAAGCGACCCAAGCAGCCTGATAAAGAA
GGAAAGTTAATCTGTTCTGAAAAGGGGAAAGTGTCAGAGAAAAGTCTTCCCAAGAACGAGAAGGAAGACAAGGAAAACATTTCCGAAAAT
GACAGAGAGTATTCTGGAGATGCCCAAGTGGATAAGAAACCTGAAAATGACATTGTGAAGAGTCCACAAGAAAACTTGAGGGAACCCAAA
AGAAAACGAGGCAGACCCCCTTCCATAGCTCCTACTGCTGTGGATTCAAACTCTCAAACTTTGCAACCAATAACATTGGAACTGAGAAGA
AGGAAAATATCAAAAGGATGTGAAGTCCCATTAAAACGTCCTCGGCTTGACAAAAATTCATCCCAGGAAAAGTCAAAAAACTACTCGGAA
AACACTGACAAAGACTTATCGAGGAGACGTTCCTCCAGGCTGTCCACTAATGGGACCCATGAGATCCTAGATCCTGACTTGGTTGTATCA
GATTTGGTTGATACGGATCCTTTGCAAGACACGTTGTCTAGTACCAAGGAATCTGAAGAAGGTCAGTTGAAGTCTGCTTTGGAAGCTGGC
CAGGTCTCATCTGCACTGACTTGCCACTCCTTTGGGGATGGATCCGGGGCTGCAGGCTTGGAGTTGAACTGCCCATCAATGGGAGAAAAC
ACGATGAAAACAGAACCGACTTCTCCCCTTGTGGAATTACAAGAGATTTCGACTGTGGAAGTAACAAATACTTTTAAGAAAACAGATGAT
TTTGGGTCATCTAATGCACCAGCTGTCGACCTAGACCATAAGTTTAGATGCAAAGTTGTGGACTGTTTAAAATTTTTCCGCAAAGCCAAA
CTGTTGCACTATCACATGAAGTATTTCCATGGAATGGAGAAGTCACTGGAGCCAGAAGAGAGCCCGGGAAAGAGGCATGTCCAAACCAGG
GGCCCTTCAGCTTCAGACAAGCCCAGCCAGGAGACCCTGACCAGGAAGCGGGTCTCTGCCAGTTCCCCAACTACAAAAGACAAGGAAAAG
AATAAAGAGAAGAAATTCAAGGAGTTTGTGAGAGTGAAGCCAAAGAAGAAAAAGAAAAAGAAAAAGAAAACCAAACCTGAATGCCCCTGC
AGTGAGGAGATCAGTGACACCTCCCAGGAACCTTCTCCACCCAAGGCATTTGCTGTTACCAGGTGTGGGTCCTCACACAAGCCAGGGGTC
CATATGAGCCCGCAGCTTCATGGCCCAGAATCTGGACACCACAAAGGGAAAGTGAAAGCATTGGAGGAGGATAATTTGAGTGAGTCCTCT
TCTGAGAGCTTTCTCTGGAGTGATGATGAGTATGGCCAAGATGTGGATGTGACCACCAACCCAGATGAGGAACTTGATGGGGATGACCGC
TATGACTTCGAGGTGGTCCGCTGCATCTGTGAGGTCCAGGAGGAAAATGACTTCATGATTCAGTGTGAAGAGTGCCAGTGCTGGCAGCAT
GGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGCTTC
AAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCCAAG
AAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTGCAA
AGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCTGTC
ACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTGCCG
CGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTGGTG
GAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCTCTA
GACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAAGAA
GCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTGGAA
TCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATC
ATAGCCAGCACCTGGGCTCTGACGCCCACTCACTACCTCACCAAGCATGACGTGGAGAGACTAAAAGCCTCGCTGGATCGCCCTTTCACA
AATTTGGAATCTGCCTTCTACTCCATCGTGGGACTCAGCAGCCTTGGTGCTCAGGTGCCAGATGCAAAGATCTCTATTTCAAATGAGACC
AAAGATCTGCTTCTGGCAGCTGTCAGTGAGGACTCATCTGTTACCCAGATCTACCATGCAGTTGCAGCTCTAAGTGGCTTTGGCCTTCCC
TTGGCATCCCAAGAAGCACTCAGTGCCCTTACTGCTCGTCTCAGCAAGGAGGAGACTGTGCTGGCAACAGTCCAGGCTCTGCAGACAGCA
TCCCACCTGTCCCAGCAGGCTGACCTGAGGAGCATCGTGGAGGAGATTGAGGACCTTGTTGCTCGCCTGGATGAACTCGGGGGCGTGTAT
CTCCAGTTTGAAGAAGGACTGGAAACAACAGCGTTATTTGTGGCTGCCACCTACAAGCTCATGGATCATGTGGGGACTGAGCCATCCATT
AAGGAGGATCAGGTCATCCAGCTGATGAACGCGATCTTCAGCAAGAAGAACTTTGAGTCCCTCTCCGAAGCCTTCAGCGTGGCCTCTGCA
GCTGCTGTGCTCTCGCATAATCGCTACCACGTGCCAGTTGTGGTTGTGCCTGAGGGCTCTGCTTCCGACACTCATGAACAGGCTATCTTG
CGGTTGCAAGTCACCAATGTTCTGTCTCAGCCTCTGACTCAGGCCACTGTTAAACTAGAACATGCTAAATCTGTTGCTTCCAGAGCCACT
GTCCTCCAGAAGACATCCTTCACCCCTGTAGGGGATGTTTTTGAACTAAATTTCATGAACGTCAAATTTTCCAGTGGTTATTATGACTTC
CTTGTCGAAGTTGAAGGTGACAACCGGTATATTGCAAATACCGTAGAGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTT
GATCTTTCCACCGTGGATAAGGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCA
GACAGCCACCAGAACTTCGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTC
CATAACCAGAAGACTGGCCAGGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGA
AAGATTGAATTTGACTCTGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTG
GCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCAC
CTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCT
CTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGA
CTCATGTATGTCTACTGGACTCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAAT
CGGATGCTGGCCCAGCAGGCAGTCAAGAGGATCGCTGCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAG
TTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAA
AAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGA
GCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTGCTTTTGAAAAGTTGAAATGTGT

>64825_64825_4_PHF20-RPN2_PHF20_chr20_34528969_ENST00000374012_RPN2_chr20_35812583_ENST00000373622_length(amino acids)=1578AA_BP=967
MKMTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQ
INEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKK
DKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAP
TAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDT
LSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDL
DHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVR
VKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKVKALEEDNLSESSSESFLWSDDEY
GQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSR
GHMHGLAFLEENYSHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPS
YRTLNGAVEKPRPLALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDP
KPGSPKVKEYVSKKALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDGSSTVFLLALTIIASTWALTPTH
YLTKHDVERLKASLDRPFTNLESAFYSIVGLSSLGAQVPDAKISISNETKDLLLAAVSEDSSVTQIYHAVAALSGFGLPLASQEALSALT
ARLSKEETVLATVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQLMNA
IFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPLTQATVKLEHAKSVASRATVLQKTSFTPVG
DVFELNFMNVKFSSGYYDFLVEVEGDNRYIANTVELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQ
LVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEE
APSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNM

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Fusion Gene PPI Analysis for PHF20-RPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF20-RPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF20-RPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource