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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF21A-CAMK1D (FusionGDB2 ID:64842)

Fusion Gene Summary for PHF21A-CAMK1D

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF21A-CAMK1D
Fusion gene ID: 64842
HgeneTgene
Gene symbol

PHF21A

CAMK1D

Gene ID

51317

57118

Gene namePHD finger protein 21Acalcium/calmodulin dependent protein kinase ID
SynonymsBHC80|BM-006|IDDBCS|NEDMSCKLiK|CaM-K1|CaMKID
Cytomap

11p11.2

10p13

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta
Modification date2020032720200313
UniProtAcc.

Q8IU85

Ensembl transtripts involved in fusion geneENST00000257821, ENST00000323180, 
ENST00000418153, ENST00000527753, 
ENST00000378845, ENST00000487696, 
ENST00000378847, 
Fusion gene scores* DoF score19 X 13 X 12=296416 X 18 X 6=1728
# samples 2219
** MAII scorelog2(22/2964*10)=-3.75197001878117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1728*10)=-3.18503189383252
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF21A [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF21A(46098305)-CAMK1D(12811672), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAMK1D

GO:0032793

positive regulation of CREB transcription factor activity

16324104


check buttonFusion gene breakpoints across PHF21A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAMK1D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09D-01APHF21Achr11

46098305

-CAMK1Dchr10

12811672

+


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Fusion Gene ORF analysis for PHF21A-CAMK1D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257821ENST00000378845PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
5CDS-intronENST00000257821ENST00000487696PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
5CDS-intronENST00000323180ENST00000378845PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
5CDS-intronENST00000323180ENST00000487696PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
5CDS-intronENST00000418153ENST00000378845PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
5CDS-intronENST00000418153ENST00000487696PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
In-frameENST00000257821ENST00000378847PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
In-frameENST00000323180ENST00000378847PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
In-frameENST00000418153ENST00000378847PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
intron-3CDSENST00000527753ENST00000378847PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
intron-intronENST00000527753ENST00000378845PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+
intron-intronENST00000527753ENST00000487696PHF21Achr11

46098305

-CAMK1Dchr10

12811672

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257821PHF21Achr1146098305-ENST00000378847CAMK1Dchr1012811672+81567776241496290
ENST00000323180PHF21Achr1146098305-ENST00000378847CAMK1Dchr1012811672+79005213681240290
ENST00000418153PHF21Achr1146098305-ENST00000378847CAMK1Dchr1012811672+77323532001072290

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257821ENST00000378847PHF21Achr1146098305-CAMK1Dchr1012811672+0.0030096810.9969903
ENST00000323180ENST00000378847PHF21Achr1146098305-CAMK1Dchr1012811672+0.00304030.9969597
ENST00000418153ENST00000378847PHF21Achr1146098305-CAMK1Dchr1012811672+0.0028188070.9971812

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Fusion Genomic Features for PHF21A-CAMK1D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PHF21Achr1146098304-CAMK1Dchr1012811671+2.95E-081
PHF21Achr1146098304-CAMK1Dchr1012811671+2.95E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PHF21A-CAMK1D


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46098305/chr10:12811672)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAMK1D

Q8IU85

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCAMK1Dchr11:46098305chr10:12811672ENST00000378845310326_364146358.0Compositional biasNote=Ser-rich
TgeneCAMK1Dchr11:46098305chr10:12811672ENST00000378847311326_364146386.0Compositional biasNote=Ser-rich
TgeneCAMK1Dchr11:46098305chr10:12811672ENST00000378845310318_324146358.0MotifNuclear export signal
TgeneCAMK1Dchr11:46098305chr10:12811672ENST00000378847311318_324146386.0MotifNuclear export signal
TgeneCAMK1Dchr11:46098305chr10:12811672ENST00000378845310279_319146358.0RegionAutoinhibitory domain
TgeneCAMK1Dchr11:46098305chr10:12811672ENST00000378845310299_320146358.0RegionCalmodulin-binding
TgeneCAMK1Dchr11:46098305chr10:12811672ENST00000378847311279_319146386.0RegionAutoinhibitory domain
TgeneCAMK1Dchr11:46098305chr10:12811672ENST00000378847311299_320146386.0RegionCalmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF21Achr11:46098305chr10:12811672ENST00000257821-518558_60351682.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:46098305chr10:12811672ENST00000323180-518558_60351635.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:46098305chr10:12811672ENST00000418153-518558_60351681.0Coiled coilOntology_term=ECO:0000255
HgenePHF21Achr11:46098305chr10:12811672ENST00000257821-5184_10851682.0Compositional biasNote=Gln-rich
HgenePHF21Achr11:46098305chr10:12811672ENST00000323180-5184_10851635.0Compositional biasNote=Gln-rich
HgenePHF21Achr11:46098305chr10:12811672ENST00000418153-5184_10851681.0Compositional biasNote=Gln-rich
HgenePHF21Achr11:46098305chr10:12811672ENST00000257821-518425_43751682.0DNA bindingNote=A.T hook
HgenePHF21Achr11:46098305chr10:12811672ENST00000323180-518425_43751635.0DNA bindingNote=A.T hook
HgenePHF21Achr11:46098305chr10:12811672ENST00000418153-518425_43751681.0DNA bindingNote=A.T hook
HgenePHF21Achr11:46098305chr10:12811672ENST00000257821-518486_68051682.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:46098305chr10:12811672ENST00000323180-518486_68051635.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:46098305chr10:12811672ENST00000418153-518486_68051681.0RegionNote=Required for transcriptional repression
HgenePHF21Achr11:46098305chr10:12811672ENST00000257821-518488_53551682.0Zinc fingerPHD-type
HgenePHF21Achr11:46098305chr10:12811672ENST00000323180-518488_53551635.0Zinc fingerPHD-type
HgenePHF21Achr11:46098305chr10:12811672ENST00000418153-518488_53551681.0Zinc fingerPHD-type
TgeneCAMK1Dchr11:46098305chr10:12811672ENST0000037884531023_279146358.0DomainProtein kinase
TgeneCAMK1Dchr11:46098305chr10:12811672ENST0000037884731123_279146386.0DomainProtein kinase
TgeneCAMK1Dchr11:46098305chr10:12811672ENST0000037884531029_37146358.0Nucleotide bindingATP
TgeneCAMK1Dchr11:46098305chr10:12811672ENST0000037884731129_37146386.0Nucleotide bindingATP


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Fusion Gene Sequence for PHF21A-CAMK1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64842_64842_1_PHF21A-CAMK1D_PHF21A_chr11_46098305_ENST00000257821_CAMK1D_chr10_12811672_ENST00000378847_length(transcript)=8156nt_BP=777nt
GGTGAATGGGCTGGTGGTGCTCGCTGCTGCTGCTGAGAGGAGGAGGAGGATGAAGAGTTGGGCTTGTTTGTCTCCTACAGTTTCTCTCCT
GCTGCTCTGATTCCCCCCTCCCGATTCCGGCCCGGGGCCTGTGTGTGTCCCTCCTGGAGGAGGAGGAGGATCCAGTTCCTCCCCCCAACC
CCCTCCTCCCCACCCCCCCTTGCCTGGGGAAGAGGAGGAAAGAAACAGCCCAGAGAGAGAGAGAGAGAGAGAGTGAGTGAGAGAGAGAGG
AGAGGAGAGGAGGAGGAGGAGGAGGGAGAAGGGAACAACCTACCATCTTAACACACTAATATCTAAAAAGTGCGAGAGGCCCAGAGCAGC
AGCAGAAGCAGCAGCAGCAGCTCCAGCTTCTTCCCTCCCTCCCCATGAAGAAGAGTTCCCTCCTCCTCCTCCTCCTGCTTCTCCTGCTCA
GAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCTGAAGGAGAGCCAGTTTCCCCAAAATT
GCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGAGAAAGTGGAGAAGGTAGAGGATGGAG
TTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAATGCTGAC
TTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGCCCGAAAATCTCTTGTACTACAGTCAAGATGAG
GAGTCCAAAATAATGATCAGTGACTTTGGATTGTCAAAAATGGAGGGCAAAGGAGATGTGATGTCCACTGCCTGTGGAACTCCAGGCTAT
GTCGCTCCTGAAGTCCTCGCCCAGAAACCTTACAGCAAAGCCGTTGACTGCTGGTCCATCGGAGTGATTGCCTACATCTTGCTCTGCGGC
TACCCTCCTTTTTATGATGAAAATGACTCCAAGCTCTTTGAGCAGATCCTCAAGGCGGAATATGAGTTTGACTCTCCCTACTGGGATGAC
ATCTCCGACTCTGCAAAAGACTTCATTCGGAACCTGATGGAGAAGGACCCGAATAAAAGATACACGTGTGAGCAGGCAGCTCGGCACCCA
TGGATCGCTGGTGACACAGCCCTCAACAAAAACATCCACGAGTCCGTCAGCGCCCAGATCCGGAAAAACTTTGCCAAGAGCAAATGGAGA
CAAGCATTTAATGCCACGGCCGTCGTCAGACATATGAGAAAACTACACCTCGGCAGCAGCCTGGACAGTTCAAATGCAAGTGTTTCGAGC
AGCCTCAGTTTGGCCAGCCAAAAAGACTGTCTGGCACCTTCCACGCTCTGTAGTTTCATTTCTTCTTCGTCGGGGGTCTCAGGAGTTGGA
GCCGAGCGGAGACCCAGGCCCACCACTGTGACGGCAGTGCACTCTGGAAGCAAGTGACTGGCCCTGGAGGTGGGGCCCGGGGTCGGGGCT
GGGGAAGGGGAGCCCCAGGGTCGCCAGAGCCGCGAGCCACTCCAGCGAGACCCCACCTTGCATGGTGCCCCTTCCTGCATAGGACTGGAA
GACCGAAGTTTTTTTATGGCCATATTTTCTACTGCAATTCTGAAGTGTTCATTTCTCACAAACTGTACTGACTCGAGGGGCGCTGATTTC
ATAGGATCTGGTGCTGTATATACGAATCTTGCAAAGCTCTAACTGAACGGACCTTCTTATTCCTCTCCCCTAACACCATCGTTTCCACTC
TTCTCAGTGTAGGTAACCGTCTATGGTGTGTTTTTTCATTAATGACAAAAAAAAAAAGGTTTCAACTGGATTATTTAAATATTGGTAAAT
ATTGTGCATTAGGGTTTGTTTTTCCTTTTAAGAAGTATGTCCTTTGTATCTCTAAGTTACATGACCTATATCTTTTCCTCTTTAATAGTA
GTTTTATGTTAACCTTTAAGAGATTTGTTTTTCCTCAAAGGAGAATTTAAAGGTATTTTTTAAAATTCTAATAAGAGGATCAGCCGGGTG
CAATGACTCATGCCTGTAATCCCAGCACGTTGGGAGGCCAAGTCGGGCGGATCACAAGGTCAGGAGATCAAGGCCATCCTGGCCAACATG
GTGAAACCCCACGTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCACACACCTGTAGTCCCGGCTACTCGGGAGGCTGAGGCAG
GAGAATTGCTTGAACCCGGGAGACGGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTC
TCAAAAAAAAAAAAAAAAATTCTAACAAGAGGATCATGAATCTGTCTCCAAGGCTAAGAGTGCCCTTCACCTCTACTCCTTCTGTTTCTC
TCCCCTTCCCCAGGAGGAGGGGCCCCTCAGTTCTGCGAGGCTCTCTTCTCTGCGGGGGACTTTGGTAGAGAATCTGCACAGAGCCTTTGC
TGGCAACCCATCCAGCAGAACCCACACCCACCAGAGACCCTAGAGGCCTCTTGCCATCAGCAACCAGAAATAAGCCTGCTCCCCCGAGAC
GCAGGGCTCAGCTTCACAGGCCAGACTTGCTGTGAGTGAGATGCCCACACTGCAGAGATGCAGGACCCTCCCTTGCAAAAGGAACCAGCT
GCCATGTTGCTGAAAGTGGGCCCACACACAACCCTCATTTCTCACGAGAGCTAACAGATGAAAGCTCAGCTATGCAGTGTTAAAATTCAT
CTCTTTCTCTGTGGTTTTTAAAAAAATGCATTTCTAATCTTACACTTCACGTGGCCTCCAACACAAAGTTCTTTCTCCACATTTTTACCC
TCTTCTCACATGAATGTTTTCCAAGGGAAGGAAGGGAGGGAAGCAGCCTTGGGAAAGGATCCATTTCTGGTGGTAAGGAGAGGGGGCCCT
GCCAGGCTAATGGGACTTCAGCCACCACAGAGATGACCAAAGACCACCTCCGCCAGGCCCAGCCAGTGCTTGCAGCCCTCCCATTGGTCA
GGGGAGTCTAAAATCAAAGATACATGGTGGTAGGGTCACCAAACGTCCCATTTGCCCGAGACTGAAGGATTTCTCAGGCTGTGGACATTT
AATGCCAAAACCAGGAATATCCGGGGCAAAGCAGGCTGTGTTGTTCGCCTTTGTGGAGCCAGGCAGTGTGTGGCCCAGGGAAAGCTGCGT
TTCATGGAGGCTTCCAGGAGGCTGCCCTGTAAAGCCAGGCAGGTGGCTTCAAGTGCCATTCCTGCAAGTGCCCCTGCTTCAGCTCTCAGG
CCCATCCAATGCCTCGAGCCCACGGGGGTGTCCCGGCAGGTCTGCGTCATCACGACCCAGTAACGCTGCTGGCTGTGTCCTCATGCCCTC
TTCCTCTGGCTGGCCAGTCATGGGAAGTCCTGTTGGTTGAGTCATCTTTGTCACTTCTACACCTTTGAGTATGTACAGGCTGAATGTTGA
GTGATGCCCCCCCACCCTCTCAATAAACACACACACACACACACACACACACACACACACACACAATGTTATTAGGCACAGCAGCTCCAT
CCTGCTCCCTGAGAATGGCAGTGCAGGCACAGAGAAGAGCAGTTGGGAAGACAGGCAGCTGGTCTACCCTGTCCCCGCACACTTCACAGG
CACTCCACTGCTTGGCAGGAATTCTGCATGGCATCTGCCACGCATGCTCACAGGGTGAAAAATCAAGCTGTCACTCTGCAAAATCTAAAA
ACCCTGGAAAGGTCTATAAGATGACATTAGACCCAGTTAAGAAGCAAGTGTCACCTGAGTTGGCCATGCAATGAATGAATATTATAAGCA
GTATTGGAGAACTAGGCGGTTGCTTACTAAGAAGTGTCTTGGAAACATTCGAGTTCATACAGTGCATGACAAAGTAATAGAAGGCTGCAA
GCGCTGAAAATGCACCCGAATCTGGTACCTAGGATGAGTACATGAATAGTGATGAATAGCCCTTTGTGCTGTGTGCTATATACAACCATT
TGCATTCAGAAAGCAGCATTTGAAGCTGAGTTCCATTACTGGTGATTGAAGTATTTTCAGGAGCAGATACATGTGGTGCATGTTATATGC
ACTTAGTTTGAAAGTATCCCTCACCCAAAAAGTGCAGAACCTCTGAAAGGTGAGCCGTGGTGCAGGTGCCCCCCTCGCTGTTCGGGTCAG
TTCTTGGCCATGCTTGGCCTGTCACACGCCGGGTCTCAACAACATCGTGCGAGGAGACAGTGACTGGTTTCAGCCCAAGAGTCAACTGTT
GAGCATGACATCAGGAAGCCTGTACTGTCCTGATCCCACCAGGCTTGGGTTAATTTCCTATTGCTTCAGAGAAAGAGAGGCGCTCTTGTG
CTTTTGAGAGAGCTCTCATGTTAAAAAGAGGTTGTCTTTGCACTGCGCTTGGTATGATTTGTTTTCTTATAAAACAGGAAGAGAACCTAG
AATGTGCCTTTCGTGAAGGTCTGACAAATGGGGTCTCAGAGTCCTAGGACCCGCACCAAGGTCAGAGTCCACCTGTAGAGGCTGAGCATT
TCTACATGCACCCAGGGTGCTGGGCTGAGGCTAAGGGTGGACGCGTAGACCCCATCACAGGCTTCCTTCCTGAGCCCAAGTCCCCCATTT
GGTCACTATCCCTTCTCAGAGCAAGTGGATTCTCTTTTCCTCACTTGGAGTATTCAATGTTGAAGTAGTGGCCTGGAGTGGCCTTTCCCT
CAGCTGCCTGTCTGGGCCTCCCTGGCTTCCCGGATCTTCATCTCATACGTGAGGCAATAGGAGGAGTTTCTATTCATTGAGACAAACAGT
GAGCGGGCACCAACAGGCCAGCAGCTTGGCCCTTTTCACAGAGGTGGCCTTGGAGTCTGGAGTCTGGGCAGCTGTCTGCCTCTCTACGGC
TCTGCTTCCCAGCGGGCACACGGGTCCGGAGCCTCAGAATGAAGTGGTGCAGAGGCGCAGGGCACACCTAGGAGAAGCTCAATGACCACC
AAAGCCCTTGAGGAGAGACGGGGTTTGCTGTGTTAGAGAAATGGCAACCCCCAGGACCATGCACGGCTCTGGCAGTGCACAGTGGCTGAT
TTTCACCAGTTCCTCCTACCCCTGCCTCTGTCGGAGACTAGAAAACATTCTACCCCTTCAGGTCTTCTTTTAAAAGAAAAGAGCTATGGC
AAAGCGTGCCATACAAAGTTAAAAAAAGGAAGAGTGGCTTTGCGTTCTTGACCATGGCCACAATTCTGGTCACTTCTAGCATCTGACCTT
GAGAACGGTGTAGAGTCTCTGAGCCACCGCTGGCCTTTGAGAGAGTCTCACTCTCCAGCTAGCTCTTTGTGTAGTGTCCAGGGCCCCGGC
AGTCAGGATAGAGCGAGCAAAAGAAGATGGACAGTGGACAGGGCGCAGTGGCTCACGCCTGTAATCCCAGCGCTTTGGGAGAGCGAGGCG
GGCAGATCACAAGGTCAAGAGATCAAGACCATTCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAATTAGCTGGGCATG
GTGGTGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGAT
CGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAGATGGCCATGCTGGCCAAGGCTGGGCTCATAGGAAATA
TCTGTAGTAGGATGAAAGGAATCTGGCCTAGGGAGCCCCGGACTCGGTTTACCTACCCCGTACTCATCCCACTCATCTGTCTACCCTAGT
GTCCATCATGCCCTGGATGAATCGTAGGTGGGAGGGACAGAAGCCGAGAACACCAGGCACACGGGGTGGGGGGAATGGGGGGAGCCCAGG
TGATCCCCTTTGGAAAGTGGATTGATCCTCTCCCCTGTGGAATGACAGCTTAACCTGATTAACCCACTGGGGCTTGCTATTTTATGAGCA
TTTTTAAACAGAAAGGAAAGATGATATCCCAGTGCAGGTAGACTTTATTTTTGAAAGCATCGTGGCCCCTCACCTCTCCCTCTCCCCCAG
AACCTTGGCCAGAATTGAGTCTTCGCGTTGGGGAGGCCACGCTGGAACCATTGCTCTAGGGCTGAAGGTGGAAGTAGGGCCACTGCCGCA
GCTTCAGCCAGAGCCCTCGCTGCTTCGCAGAATTTAACAAGCACACGACTGGGATTCCTTTGGATATGAGAAAGGAAGGCAAGTGCGGGC
AAAGGGAAGCTCCTCCCGTTTTTCATAAACAGAAGTAAGATGTCCTCTTTCCCAGGTTTGCACAATCACTTCTGGCAAATTAATTGAAGG
TCCTTGAATTCAGCCAGTGCACGAAACCTTTGCATGTTCTTCTGAAACTGTACTTCTTCCCTATTCTGTCTACCCACACTCTGCGAACTT
TGCCTTTTCCTTAAACACATTCCAGACCAAACACTGTTCAGTTTGTTAAAAAAAAAAAAAAAAAAAAAAGATGTATATACCTGTATGTGA
TCCACCACCCTTTTGAGGGGCACCTGGTCCTCGGTTGGGGCTGCAGGTGTGCCTGACATTTGCAAAAGATATTCCAGTCTTTCGATGTTC
AGAATTGAAAATGTGGAGATAGAAAAGCTCAAACAGACTCCTAAAAGGAGGGTTTCTTTCCTGAAGACTCCAAGAAAATGAGTGTGCAGA
TGAGTTAGCTTGACAACCTCAACTCTGGGGAGCAGGCAGGCGGTCTGAGGAAGATAAGGGCCCACGCCCCACTCACCTGGCACCTGTTCG
GTGGTCCCGGGGCATCATGGTCTGCAGCTCTGGGCCCCCAGCCCCACTGTGAAGTCAGTCCTGCATGCTGGCCGAGGCCCGGCCACCTCC
CGATGCCTCCAGAGTCAGTGGGAAGGAGTCAGCCCTTCCCAGACTTCCCCGCCACCTCCAGCAGGAGCAGCTCAGTTTGTGGCTCTGGGA
GCTCCGCTTTTGCAAACCCAAAAAGGCTGTGCATTTGGAAGCCAAACGCTCAGCATGCGGCTGCCGAGTCTGGTTTTGTGGACAAAGCAA
ACTGTGGAATGGCTTCTCGGTGTCTGTATAAAGGGACAAACGGTTGCATTCACCCTTTGTACTATAACACCGCTTCTGCATTCGCCATAT
CCGTTTTTTAACCTTTTTGTCTCCGGGGAACTTCTCATTCGATTATTATGTCTTCTGATGATTTGCCATGTTATTTTAAAGGTGATTTTA
TTTTCTTATGGACAGGAAAAAAGAAAATGAGGAGGAGTTGGTTTTACTCTTAGAGATAAGACTTCAGCAGGGGCTCAGAAACCCCAAACT
CTAGTTAAATTGCTTCTCGGAGGAAAATCTTAATCTAGACAGATTCAGATTCCCAGGCTCTCCTGGAAGCCCTGCACTTCAGGGCACAGG
GGCCCTGGGACGTGGTTGGCAGCCAGGCTGCGAGAGAGCTAAAAAGGAACAAGAACATCAGCTCGGATGTTTGTCTCTCAGCCCTGACAC
CTGCCACTCTCCTTCCCGGGGCACTTGGCCCTATCAGAGGGACATGAAATGCTGTCCGAATGGTGGCAGAAATGCAGCGACATTGCATGC
AGCAGAGTCTTTGCTTCGAAAGATGGGGCGCCATGTTTCAGAGAACATTTATCTTAGTCCCACGTTCAGGTGAGAAGACCTCAAAGGTAC
CCTCTGTCCAGAATAAACATTGGAACAATCTCTCAATTGGCTTTTGTCACTACACATAATGTAATCTCCCTTCTTTCAGCTCCCCCAACA
GTGAGCATGCTTCCCAAAAAATTACAACATCAAAACCAGGAATGTCCCCGCATCTACTATTACCAGGCTTGCAATTGGTTCAATTTTCCC
ATAAAAACATGTTTGTCCAAAAGAAGGGAAACTGTGAATTTATTCCATGCATGTAATAAACTCTGCAAGAAGTTTAACCCACATAGGTTT
GCGGCACTGCAAAATTGTTCATGGGTCTATGTAGCAAATGATTCTCTGCCTTGACAATCATGTATACATATCAAGATTTCTATCATAATG

>64842_64842_1_PHF21A-CAMK1D_PHF21A_chr11_46098305_ENST00000257821_CAMK1D_chr10_12811672_ENST00000378847_length(amino acids)=290AA_BP=51
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP
GYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAAR
HPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSG

--------------------------------------------------------------
>64842_64842_2_PHF21A-CAMK1D_PHF21A_chr11_46098305_ENST00000323180_CAMK1D_chr10_12811672_ENST00000378847_length(transcript)=7900nt_BP=521nt
GTGAGAGAGAGAGGAGAGGAGAGGAGGAGGAGGAGGAGGGAGAAGGGAACAACCTACCATCTTAACACACTAATATCTAAAAAGTGCGAG
AGGCCCAGAGCAGCAGCAGAAGCAGCAGCAGCAGCTCCAGCTTCTTCCCTCCCTCCCCATGAAGAAGAGTTCCCTCCTCCTCCTCCTCCT
GCTTCTCCTGCTCAGAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCTGAAGGAGAGCCA
GTTTCCCCAAAATTGCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGAGAAAGTGGAGAA
GGTAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATC
CACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGCCCGAAAATCTCTTGTACT
ACAGTCAAGATGAGGAGTCCAAAATAATGATCAGTGACTTTGGATTGTCAAAAATGGAGGGCAAAGGAGATGTGATGTCCACTGCCTGTG
GAACTCCAGGCTATGTCGCTCCTGAAGTCCTCGCCCAGAAACCTTACAGCAAAGCCGTTGACTGCTGGTCCATCGGAGTGATTGCCTACA
TCTTGCTCTGCGGCTACCCTCCTTTTTATGATGAAAATGACTCCAAGCTCTTTGAGCAGATCCTCAAGGCGGAATATGAGTTTGACTCTC
CCTACTGGGATGACATCTCCGACTCTGCAAAAGACTTCATTCGGAACCTGATGGAGAAGGACCCGAATAAAAGATACACGTGTGAGCAGG
CAGCTCGGCACCCATGGATCGCTGGTGACACAGCCCTCAACAAAAACATCCACGAGTCCGTCAGCGCCCAGATCCGGAAAAACTTTGCCA
AGAGCAAATGGAGACAAGCATTTAATGCCACGGCCGTCGTCAGACATATGAGAAAACTACACCTCGGCAGCAGCCTGGACAGTTCAAATG
CAAGTGTTTCGAGCAGCCTCAGTTTGGCCAGCCAAAAAGACTGTCTGGCACCTTCCACGCTCTGTAGTTTCATTTCTTCTTCGTCGGGGG
TCTCAGGAGTTGGAGCCGAGCGGAGACCCAGGCCCACCACTGTGACGGCAGTGCACTCTGGAAGCAAGTGACTGGCCCTGGAGGTGGGGC
CCGGGGTCGGGGCTGGGGAAGGGGAGCCCCAGGGTCGCCAGAGCCGCGAGCCACTCCAGCGAGACCCCACCTTGCATGGTGCCCCTTCCT
GCATAGGACTGGAAGACCGAAGTTTTTTTATGGCCATATTTTCTACTGCAATTCTGAAGTGTTCATTTCTCACAAACTGTACTGACTCGA
GGGGCGCTGATTTCATAGGATCTGGTGCTGTATATACGAATCTTGCAAAGCTCTAACTGAACGGACCTTCTTATTCCTCTCCCCTAACAC
CATCGTTTCCACTCTTCTCAGTGTAGGTAACCGTCTATGGTGTGTTTTTTCATTAATGACAAAAAAAAAAAGGTTTCAACTGGATTATTT
AAATATTGGTAAATATTGTGCATTAGGGTTTGTTTTTCCTTTTAAGAAGTATGTCCTTTGTATCTCTAAGTTACATGACCTATATCTTTT
CCTCTTTAATAGTAGTTTTATGTTAACCTTTAAGAGATTTGTTTTTCCTCAAAGGAGAATTTAAAGGTATTTTTTAAAATTCTAATAAGA
GGATCAGCCGGGTGCAATGACTCATGCCTGTAATCCCAGCACGTTGGGAGGCCAAGTCGGGCGGATCACAAGGTCAGGAGATCAAGGCCA
TCCTGGCCAACATGGTGAAACCCCACGTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCACACACCTGTAGTCCCGGCTACTCG
GGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGACGGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAG
AGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAATTCTAACAAGAGGATCATGAATCTGTCTCCAAGGCTAAGAGTGCCCTTCACCTCTAC
TCCTTCTGTTTCTCTCCCCTTCCCCAGGAGGAGGGGCCCCTCAGTTCTGCGAGGCTCTCTTCTCTGCGGGGGACTTTGGTAGAGAATCTG
CACAGAGCCTTTGCTGGCAACCCATCCAGCAGAACCCACACCCACCAGAGACCCTAGAGGCCTCTTGCCATCAGCAACCAGAAATAAGCC
TGCTCCCCCGAGACGCAGGGCTCAGCTTCACAGGCCAGACTTGCTGTGAGTGAGATGCCCACACTGCAGAGATGCAGGACCCTCCCTTGC
AAAAGGAACCAGCTGCCATGTTGCTGAAAGTGGGCCCACACACAACCCTCATTTCTCACGAGAGCTAACAGATGAAAGCTCAGCTATGCA
GTGTTAAAATTCATCTCTTTCTCTGTGGTTTTTAAAAAAATGCATTTCTAATCTTACACTTCACGTGGCCTCCAACACAAAGTTCTTTCT
CCACATTTTTACCCTCTTCTCACATGAATGTTTTCCAAGGGAAGGAAGGGAGGGAAGCAGCCTTGGGAAAGGATCCATTTCTGGTGGTAA
GGAGAGGGGGCCCTGCCAGGCTAATGGGACTTCAGCCACCACAGAGATGACCAAAGACCACCTCCGCCAGGCCCAGCCAGTGCTTGCAGC
CCTCCCATTGGTCAGGGGAGTCTAAAATCAAAGATACATGGTGGTAGGGTCACCAAACGTCCCATTTGCCCGAGACTGAAGGATTTCTCA
GGCTGTGGACATTTAATGCCAAAACCAGGAATATCCGGGGCAAAGCAGGCTGTGTTGTTCGCCTTTGTGGAGCCAGGCAGTGTGTGGCCC
AGGGAAAGCTGCGTTTCATGGAGGCTTCCAGGAGGCTGCCCTGTAAAGCCAGGCAGGTGGCTTCAAGTGCCATTCCTGCAAGTGCCCCTG
CTTCAGCTCTCAGGCCCATCCAATGCCTCGAGCCCACGGGGGTGTCCCGGCAGGTCTGCGTCATCACGACCCAGTAACGCTGCTGGCTGT
GTCCTCATGCCCTCTTCCTCTGGCTGGCCAGTCATGGGAAGTCCTGTTGGTTGAGTCATCTTTGTCACTTCTACACCTTTGAGTATGTAC
AGGCTGAATGTTGAGTGATGCCCCCCCACCCTCTCAATAAACACACACACACACACACACACACACACACACACACACAATGTTATTAGG
CACAGCAGCTCCATCCTGCTCCCTGAGAATGGCAGTGCAGGCACAGAGAAGAGCAGTTGGGAAGACAGGCAGCTGGTCTACCCTGTCCCC
GCACACTTCACAGGCACTCCACTGCTTGGCAGGAATTCTGCATGGCATCTGCCACGCATGCTCACAGGGTGAAAAATCAAGCTGTCACTC
TGCAAAATCTAAAAACCCTGGAAAGGTCTATAAGATGACATTAGACCCAGTTAAGAAGCAAGTGTCACCTGAGTTGGCCATGCAATGAAT
GAATATTATAAGCAGTATTGGAGAACTAGGCGGTTGCTTACTAAGAAGTGTCTTGGAAACATTCGAGTTCATACAGTGCATGACAAAGTA
ATAGAAGGCTGCAAGCGCTGAAAATGCACCCGAATCTGGTACCTAGGATGAGTACATGAATAGTGATGAATAGCCCTTTGTGCTGTGTGC
TATATACAACCATTTGCATTCAGAAAGCAGCATTTGAAGCTGAGTTCCATTACTGGTGATTGAAGTATTTTCAGGAGCAGATACATGTGG
TGCATGTTATATGCACTTAGTTTGAAAGTATCCCTCACCCAAAAAGTGCAGAACCTCTGAAAGGTGAGCCGTGGTGCAGGTGCCCCCCTC
GCTGTTCGGGTCAGTTCTTGGCCATGCTTGGCCTGTCACACGCCGGGTCTCAACAACATCGTGCGAGGAGACAGTGACTGGTTTCAGCCC
AAGAGTCAACTGTTGAGCATGACATCAGGAAGCCTGTACTGTCCTGATCCCACCAGGCTTGGGTTAATTTCCTATTGCTTCAGAGAAAGA
GAGGCGCTCTTGTGCTTTTGAGAGAGCTCTCATGTTAAAAAGAGGTTGTCTTTGCACTGCGCTTGGTATGATTTGTTTTCTTATAAAACA
GGAAGAGAACCTAGAATGTGCCTTTCGTGAAGGTCTGACAAATGGGGTCTCAGAGTCCTAGGACCCGCACCAAGGTCAGAGTCCACCTGT
AGAGGCTGAGCATTTCTACATGCACCCAGGGTGCTGGGCTGAGGCTAAGGGTGGACGCGTAGACCCCATCACAGGCTTCCTTCCTGAGCC
CAAGTCCCCCATTTGGTCACTATCCCTTCTCAGAGCAAGTGGATTCTCTTTTCCTCACTTGGAGTATTCAATGTTGAAGTAGTGGCCTGG
AGTGGCCTTTCCCTCAGCTGCCTGTCTGGGCCTCCCTGGCTTCCCGGATCTTCATCTCATACGTGAGGCAATAGGAGGAGTTTCTATTCA
TTGAGACAAACAGTGAGCGGGCACCAACAGGCCAGCAGCTTGGCCCTTTTCACAGAGGTGGCCTTGGAGTCTGGAGTCTGGGCAGCTGTC
TGCCTCTCTACGGCTCTGCTTCCCAGCGGGCACACGGGTCCGGAGCCTCAGAATGAAGTGGTGCAGAGGCGCAGGGCACACCTAGGAGAA
GCTCAATGACCACCAAAGCCCTTGAGGAGAGACGGGGTTTGCTGTGTTAGAGAAATGGCAACCCCCAGGACCATGCACGGCTCTGGCAGT
GCACAGTGGCTGATTTTCACCAGTTCCTCCTACCCCTGCCTCTGTCGGAGACTAGAAAACATTCTACCCCTTCAGGTCTTCTTTTAAAAG
AAAAGAGCTATGGCAAAGCGTGCCATACAAAGTTAAAAAAAGGAAGAGTGGCTTTGCGTTCTTGACCATGGCCACAATTCTGGTCACTTC
TAGCATCTGACCTTGAGAACGGTGTAGAGTCTCTGAGCCACCGCTGGCCTTTGAGAGAGTCTCACTCTCCAGCTAGCTCTTTGTGTAGTG
TCCAGGGCCCCGGCAGTCAGGATAGAGCGAGCAAAAGAAGATGGACAGTGGACAGGGCGCAGTGGCTCACGCCTGTAATCCCAGCGCTTT
GGGAGAGCGAGGCGGGCAGATCACAAGGTCAAGAGATCAAGACCATTCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAA
ATTAGCTGGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTG
CAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAGATGGCCATGCTGGCCAAGGCTGG
GCTCATAGGAAATATCTGTAGTAGGATGAAAGGAATCTGGCCTAGGGAGCCCCGGACTCGGTTTACCTACCCCGTACTCATCCCACTCAT
CTGTCTACCCTAGTGTCCATCATGCCCTGGATGAATCGTAGGTGGGAGGGACAGAAGCCGAGAACACCAGGCACACGGGGTGGGGGGAAT
GGGGGGAGCCCAGGTGATCCCCTTTGGAAAGTGGATTGATCCTCTCCCCTGTGGAATGACAGCTTAACCTGATTAACCCACTGGGGCTTG
CTATTTTATGAGCATTTTTAAACAGAAAGGAAAGATGATATCCCAGTGCAGGTAGACTTTATTTTTGAAAGCATCGTGGCCCCTCACCTC
TCCCTCTCCCCCAGAACCTTGGCCAGAATTGAGTCTTCGCGTTGGGGAGGCCACGCTGGAACCATTGCTCTAGGGCTGAAGGTGGAAGTA
GGGCCACTGCCGCAGCTTCAGCCAGAGCCCTCGCTGCTTCGCAGAATTTAACAAGCACACGACTGGGATTCCTTTGGATATGAGAAAGGA
AGGCAAGTGCGGGCAAAGGGAAGCTCCTCCCGTTTTTCATAAACAGAAGTAAGATGTCCTCTTTCCCAGGTTTGCACAATCACTTCTGGC
AAATTAATTGAAGGTCCTTGAATTCAGCCAGTGCACGAAACCTTTGCATGTTCTTCTGAAACTGTACTTCTTCCCTATTCTGTCTACCCA
CACTCTGCGAACTTTGCCTTTTCCTTAAACACATTCCAGACCAAACACTGTTCAGTTTGTTAAAAAAAAAAAAAAAAAAAAAAGATGTAT
ATACCTGTATGTGATCCACCACCCTTTTGAGGGGCACCTGGTCCTCGGTTGGGGCTGCAGGTGTGCCTGACATTTGCAAAAGATATTCCA
GTCTTTCGATGTTCAGAATTGAAAATGTGGAGATAGAAAAGCTCAAACAGACTCCTAAAAGGAGGGTTTCTTTCCTGAAGACTCCAAGAA
AATGAGTGTGCAGATGAGTTAGCTTGACAACCTCAACTCTGGGGAGCAGGCAGGCGGTCTGAGGAAGATAAGGGCCCACGCCCCACTCAC
CTGGCACCTGTTCGGTGGTCCCGGGGCATCATGGTCTGCAGCTCTGGGCCCCCAGCCCCACTGTGAAGTCAGTCCTGCATGCTGGCCGAG
GCCCGGCCACCTCCCGATGCCTCCAGAGTCAGTGGGAAGGAGTCAGCCCTTCCCAGACTTCCCCGCCACCTCCAGCAGGAGCAGCTCAGT
TTGTGGCTCTGGGAGCTCCGCTTTTGCAAACCCAAAAAGGCTGTGCATTTGGAAGCCAAACGCTCAGCATGCGGCTGCCGAGTCTGGTTT
TGTGGACAAAGCAAACTGTGGAATGGCTTCTCGGTGTCTGTATAAAGGGACAAACGGTTGCATTCACCCTTTGTACTATAACACCGCTTC
TGCATTCGCCATATCCGTTTTTTAACCTTTTTGTCTCCGGGGAACTTCTCATTCGATTATTATGTCTTCTGATGATTTGCCATGTTATTT
TAAAGGTGATTTTATTTTCTTATGGACAGGAAAAAAGAAAATGAGGAGGAGTTGGTTTTACTCTTAGAGATAAGACTTCAGCAGGGGCTC
AGAAACCCCAAACTCTAGTTAAATTGCTTCTCGGAGGAAAATCTTAATCTAGACAGATTCAGATTCCCAGGCTCTCCTGGAAGCCCTGCA
CTTCAGGGCACAGGGGCCCTGGGACGTGGTTGGCAGCCAGGCTGCGAGAGAGCTAAAAAGGAACAAGAACATCAGCTCGGATGTTTGTCT
CTCAGCCCTGACACCTGCCACTCTCCTTCCCGGGGCACTTGGCCCTATCAGAGGGACATGAAATGCTGTCCGAATGGTGGCAGAAATGCA
GCGACATTGCATGCAGCAGAGTCTTTGCTTCGAAAGATGGGGCGCCATGTTTCAGAGAACATTTATCTTAGTCCCACGTTCAGGTGAGAA
GACCTCAAAGGTACCCTCTGTCCAGAATAAACATTGGAACAATCTCTCAATTGGCTTTTGTCACTACACATAATGTAATCTCCCTTCTTT
CAGCTCCCCCAACAGTGAGCATGCTTCCCAAAAAATTACAACATCAAAACCAGGAATGTCCCCGCATCTACTATTACCAGGCTTGCAATT
GGTTCAATTTTCCCATAAAAACATGTTTGTCCAAAAGAAGGGAAACTGTGAATTTATTCCATGCATGTAATAAACTCTGCAAGAAGTTTA
ACCCACATAGGTTTGCGGCACTGCAAAATTGTTCATGGGTCTATGTAGCAAATGATTCTCTGCCTTGACAATCATGTATACATATCAAGA

>64842_64842_2_PHF21A-CAMK1D_PHF21A_chr11_46098305_ENST00000323180_CAMK1D_chr10_12811672_ENST00000378847_length(amino acids)=290AA_BP=51
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP
GYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAAR
HPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSG

--------------------------------------------------------------
>64842_64842_3_PHF21A-CAMK1D_PHF21A_chr11_46098305_ENST00000418153_CAMK1D_chr10_12811672_ENST00000378847_length(transcript)=7732nt_BP=353nt
CCTCCTCCTCCTGCTTCTCCTGCTCAGAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCT
GAAGGAGAGCCAGTTTCCCCAAAATTGCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGA
GAAAGTGGAGAAGGTAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAA
TGAAGCAGGATCCACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGCCCGAAA
ATCTCTTGTACTACAGTCAAGATGAGGAGTCCAAAATAATGATCAGTGACTTTGGATTGTCAAAAATGGAGGGCAAAGGAGATGTGATGT
CCACTGCCTGTGGAACTCCAGGCTATGTCGCTCCTGAAGTCCTCGCCCAGAAACCTTACAGCAAAGCCGTTGACTGCTGGTCCATCGGAG
TGATTGCCTACATCTTGCTCTGCGGCTACCCTCCTTTTTATGATGAAAATGACTCCAAGCTCTTTGAGCAGATCCTCAAGGCGGAATATG
AGTTTGACTCTCCCTACTGGGATGACATCTCCGACTCTGCAAAAGACTTCATTCGGAACCTGATGGAGAAGGACCCGAATAAAAGATACA
CGTGTGAGCAGGCAGCTCGGCACCCATGGATCGCTGGTGACACAGCCCTCAACAAAAACATCCACGAGTCCGTCAGCGCCCAGATCCGGA
AAAACTTTGCCAAGAGCAAATGGAGACAAGCATTTAATGCCACGGCCGTCGTCAGACATATGAGAAAACTACACCTCGGCAGCAGCCTGG
ACAGTTCAAATGCAAGTGTTTCGAGCAGCCTCAGTTTGGCCAGCCAAAAAGACTGTCTGGCACCTTCCACGCTCTGTAGTTTCATTTCTT
CTTCGTCGGGGGTCTCAGGAGTTGGAGCCGAGCGGAGACCCAGGCCCACCACTGTGACGGCAGTGCACTCTGGAAGCAAGTGACTGGCCC
TGGAGGTGGGGCCCGGGGTCGGGGCTGGGGAAGGGGAGCCCCAGGGTCGCCAGAGCCGCGAGCCACTCCAGCGAGACCCCACCTTGCATG
GTGCCCCTTCCTGCATAGGACTGGAAGACCGAAGTTTTTTTATGGCCATATTTTCTACTGCAATTCTGAAGTGTTCATTTCTCACAAACT
GTACTGACTCGAGGGGCGCTGATTTCATAGGATCTGGTGCTGTATATACGAATCTTGCAAAGCTCTAACTGAACGGACCTTCTTATTCCT
CTCCCCTAACACCATCGTTTCCACTCTTCTCAGTGTAGGTAACCGTCTATGGTGTGTTTTTTCATTAATGACAAAAAAAAAAAGGTTTCA
ACTGGATTATTTAAATATTGGTAAATATTGTGCATTAGGGTTTGTTTTTCCTTTTAAGAAGTATGTCCTTTGTATCTCTAAGTTACATGA
CCTATATCTTTTCCTCTTTAATAGTAGTTTTATGTTAACCTTTAAGAGATTTGTTTTTCCTCAAAGGAGAATTTAAAGGTATTTTTTAAA
ATTCTAATAAGAGGATCAGCCGGGTGCAATGACTCATGCCTGTAATCCCAGCACGTTGGGAGGCCAAGTCGGGCGGATCACAAGGTCAGG
AGATCAAGGCCATCCTGGCCAACATGGTGAAACCCCACGTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCACACACCTGTAGT
CCCGGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGACGGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAG
CCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAATTCTAACAAGAGGATCATGAATCTGTCTCCAAGGCTAAGAGTGCC
CTTCACCTCTACTCCTTCTGTTTCTCTCCCCTTCCCCAGGAGGAGGGGCCCCTCAGTTCTGCGAGGCTCTCTTCTCTGCGGGGGACTTTG
GTAGAGAATCTGCACAGAGCCTTTGCTGGCAACCCATCCAGCAGAACCCACACCCACCAGAGACCCTAGAGGCCTCTTGCCATCAGCAAC
CAGAAATAAGCCTGCTCCCCCGAGACGCAGGGCTCAGCTTCACAGGCCAGACTTGCTGTGAGTGAGATGCCCACACTGCAGAGATGCAGG
ACCCTCCCTTGCAAAAGGAACCAGCTGCCATGTTGCTGAAAGTGGGCCCACACACAACCCTCATTTCTCACGAGAGCTAACAGATGAAAG
CTCAGCTATGCAGTGTTAAAATTCATCTCTTTCTCTGTGGTTTTTAAAAAAATGCATTTCTAATCTTACACTTCACGTGGCCTCCAACAC
AAAGTTCTTTCTCCACATTTTTACCCTCTTCTCACATGAATGTTTTCCAAGGGAAGGAAGGGAGGGAAGCAGCCTTGGGAAAGGATCCAT
TTCTGGTGGTAAGGAGAGGGGGCCCTGCCAGGCTAATGGGACTTCAGCCACCACAGAGATGACCAAAGACCACCTCCGCCAGGCCCAGCC
AGTGCTTGCAGCCCTCCCATTGGTCAGGGGAGTCTAAAATCAAAGATACATGGTGGTAGGGTCACCAAACGTCCCATTTGCCCGAGACTG
AAGGATTTCTCAGGCTGTGGACATTTAATGCCAAAACCAGGAATATCCGGGGCAAAGCAGGCTGTGTTGTTCGCCTTTGTGGAGCCAGGC
AGTGTGTGGCCCAGGGAAAGCTGCGTTTCATGGAGGCTTCCAGGAGGCTGCCCTGTAAAGCCAGGCAGGTGGCTTCAAGTGCCATTCCTG
CAAGTGCCCCTGCTTCAGCTCTCAGGCCCATCCAATGCCTCGAGCCCACGGGGGTGTCCCGGCAGGTCTGCGTCATCACGACCCAGTAAC
GCTGCTGGCTGTGTCCTCATGCCCTCTTCCTCTGGCTGGCCAGTCATGGGAAGTCCTGTTGGTTGAGTCATCTTTGTCACTTCTACACCT
TTGAGTATGTACAGGCTGAATGTTGAGTGATGCCCCCCCACCCTCTCAATAAACACACACACACACACACACACACACACACACACACAC
AATGTTATTAGGCACAGCAGCTCCATCCTGCTCCCTGAGAATGGCAGTGCAGGCACAGAGAAGAGCAGTTGGGAAGACAGGCAGCTGGTC
TACCCTGTCCCCGCACACTTCACAGGCACTCCACTGCTTGGCAGGAATTCTGCATGGCATCTGCCACGCATGCTCACAGGGTGAAAAATC
AAGCTGTCACTCTGCAAAATCTAAAAACCCTGGAAAGGTCTATAAGATGACATTAGACCCAGTTAAGAAGCAAGTGTCACCTGAGTTGGC
CATGCAATGAATGAATATTATAAGCAGTATTGGAGAACTAGGCGGTTGCTTACTAAGAAGTGTCTTGGAAACATTCGAGTTCATACAGTG
CATGACAAAGTAATAGAAGGCTGCAAGCGCTGAAAATGCACCCGAATCTGGTACCTAGGATGAGTACATGAATAGTGATGAATAGCCCTT
TGTGCTGTGTGCTATATACAACCATTTGCATTCAGAAAGCAGCATTTGAAGCTGAGTTCCATTACTGGTGATTGAAGTATTTTCAGGAGC
AGATACATGTGGTGCATGTTATATGCACTTAGTTTGAAAGTATCCCTCACCCAAAAAGTGCAGAACCTCTGAAAGGTGAGCCGTGGTGCA
GGTGCCCCCCTCGCTGTTCGGGTCAGTTCTTGGCCATGCTTGGCCTGTCACACGCCGGGTCTCAACAACATCGTGCGAGGAGACAGTGAC
TGGTTTCAGCCCAAGAGTCAACTGTTGAGCATGACATCAGGAAGCCTGTACTGTCCTGATCCCACCAGGCTTGGGTTAATTTCCTATTGC
TTCAGAGAAAGAGAGGCGCTCTTGTGCTTTTGAGAGAGCTCTCATGTTAAAAAGAGGTTGTCTTTGCACTGCGCTTGGTATGATTTGTTT
TCTTATAAAACAGGAAGAGAACCTAGAATGTGCCTTTCGTGAAGGTCTGACAAATGGGGTCTCAGAGTCCTAGGACCCGCACCAAGGTCA
GAGTCCACCTGTAGAGGCTGAGCATTTCTACATGCACCCAGGGTGCTGGGCTGAGGCTAAGGGTGGACGCGTAGACCCCATCACAGGCTT
CCTTCCTGAGCCCAAGTCCCCCATTTGGTCACTATCCCTTCTCAGAGCAAGTGGATTCTCTTTTCCTCACTTGGAGTATTCAATGTTGAA
GTAGTGGCCTGGAGTGGCCTTTCCCTCAGCTGCCTGTCTGGGCCTCCCTGGCTTCCCGGATCTTCATCTCATACGTGAGGCAATAGGAGG
AGTTTCTATTCATTGAGACAAACAGTGAGCGGGCACCAACAGGCCAGCAGCTTGGCCCTTTTCACAGAGGTGGCCTTGGAGTCTGGAGTC
TGGGCAGCTGTCTGCCTCTCTACGGCTCTGCTTCCCAGCGGGCACACGGGTCCGGAGCCTCAGAATGAAGTGGTGCAGAGGCGCAGGGCA
CACCTAGGAGAAGCTCAATGACCACCAAAGCCCTTGAGGAGAGACGGGGTTTGCTGTGTTAGAGAAATGGCAACCCCCAGGACCATGCAC
GGCTCTGGCAGTGCACAGTGGCTGATTTTCACCAGTTCCTCCTACCCCTGCCTCTGTCGGAGACTAGAAAACATTCTACCCCTTCAGGTC
TTCTTTTAAAAGAAAAGAGCTATGGCAAAGCGTGCCATACAAAGTTAAAAAAAGGAAGAGTGGCTTTGCGTTCTTGACCATGGCCACAAT
TCTGGTCACTTCTAGCATCTGACCTTGAGAACGGTGTAGAGTCTCTGAGCCACCGCTGGCCTTTGAGAGAGTCTCACTCTCCAGCTAGCT
CTTTGTGTAGTGTCCAGGGCCCCGGCAGTCAGGATAGAGCGAGCAAAAGAAGATGGACAGTGGACAGGGCGCAGTGGCTCACGCCTGTAA
TCCCAGCGCTTTGGGAGAGCGAGGCGGGCAGATCACAAGGTCAAGAGATCAAGACCATTCTGGCCAACATGGTGAAACCCTGTTTCTACT
AAAAATACAAAAATTAGCTGGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGG
AGGCAGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAGATGGCCATGCT
GGCCAAGGCTGGGCTCATAGGAAATATCTGTAGTAGGATGAAAGGAATCTGGCCTAGGGAGCCCCGGACTCGGTTTACCTACCCCGTACT
CATCCCACTCATCTGTCTACCCTAGTGTCCATCATGCCCTGGATGAATCGTAGGTGGGAGGGACAGAAGCCGAGAACACCAGGCACACGG
GGTGGGGGGAATGGGGGGAGCCCAGGTGATCCCCTTTGGAAAGTGGATTGATCCTCTCCCCTGTGGAATGACAGCTTAACCTGATTAACC
CACTGGGGCTTGCTATTTTATGAGCATTTTTAAACAGAAAGGAAAGATGATATCCCAGTGCAGGTAGACTTTATTTTTGAAAGCATCGTG
GCCCCTCACCTCTCCCTCTCCCCCAGAACCTTGGCCAGAATTGAGTCTTCGCGTTGGGGAGGCCACGCTGGAACCATTGCTCTAGGGCTG
AAGGTGGAAGTAGGGCCACTGCCGCAGCTTCAGCCAGAGCCCTCGCTGCTTCGCAGAATTTAACAAGCACACGACTGGGATTCCTTTGGA
TATGAGAAAGGAAGGCAAGTGCGGGCAAAGGGAAGCTCCTCCCGTTTTTCATAAACAGAAGTAAGATGTCCTCTTTCCCAGGTTTGCACA
ATCACTTCTGGCAAATTAATTGAAGGTCCTTGAATTCAGCCAGTGCACGAAACCTTTGCATGTTCTTCTGAAACTGTACTTCTTCCCTAT
TCTGTCTACCCACACTCTGCGAACTTTGCCTTTTCCTTAAACACATTCCAGACCAAACACTGTTCAGTTTGTTAAAAAAAAAAAAAAAAA
AAAAAGATGTATATACCTGTATGTGATCCACCACCCTTTTGAGGGGCACCTGGTCCTCGGTTGGGGCTGCAGGTGTGCCTGACATTTGCA
AAAGATATTCCAGTCTTTCGATGTTCAGAATTGAAAATGTGGAGATAGAAAAGCTCAAACAGACTCCTAAAAGGAGGGTTTCTTTCCTGA
AGACTCCAAGAAAATGAGTGTGCAGATGAGTTAGCTTGACAACCTCAACTCTGGGGAGCAGGCAGGCGGTCTGAGGAAGATAAGGGCCCA
CGCCCCACTCACCTGGCACCTGTTCGGTGGTCCCGGGGCATCATGGTCTGCAGCTCTGGGCCCCCAGCCCCACTGTGAAGTCAGTCCTGC
ATGCTGGCCGAGGCCCGGCCACCTCCCGATGCCTCCAGAGTCAGTGGGAAGGAGTCAGCCCTTCCCAGACTTCCCCGCCACCTCCAGCAG
GAGCAGCTCAGTTTGTGGCTCTGGGAGCTCCGCTTTTGCAAACCCAAAAAGGCTGTGCATTTGGAAGCCAAACGCTCAGCATGCGGCTGC
CGAGTCTGGTTTTGTGGACAAAGCAAACTGTGGAATGGCTTCTCGGTGTCTGTATAAAGGGACAAACGGTTGCATTCACCCTTTGTACTA
TAACACCGCTTCTGCATTCGCCATATCCGTTTTTTAACCTTTTTGTCTCCGGGGAACTTCTCATTCGATTATTATGTCTTCTGATGATTT
GCCATGTTATTTTAAAGGTGATTTTATTTTCTTATGGACAGGAAAAAAGAAAATGAGGAGGAGTTGGTTTTACTCTTAGAGATAAGACTT
CAGCAGGGGCTCAGAAACCCCAAACTCTAGTTAAATTGCTTCTCGGAGGAAAATCTTAATCTAGACAGATTCAGATTCCCAGGCTCTCCT
GGAAGCCCTGCACTTCAGGGCACAGGGGCCCTGGGACGTGGTTGGCAGCCAGGCTGCGAGAGAGCTAAAAAGGAACAAGAACATCAGCTC
GGATGTTTGTCTCTCAGCCCTGACACCTGCCACTCTCCTTCCCGGGGCACTTGGCCCTATCAGAGGGACATGAAATGCTGTCCGAATGGT
GGCAGAAATGCAGCGACATTGCATGCAGCAGAGTCTTTGCTTCGAAAGATGGGGCGCCATGTTTCAGAGAACATTTATCTTAGTCCCACG
TTCAGGTGAGAAGACCTCAAAGGTACCCTCTGTCCAGAATAAACATTGGAACAATCTCTCAATTGGCTTTTGTCACTACACATAATGTAA
TCTCCCTTCTTTCAGCTCCCCCAACAGTGAGCATGCTTCCCAAAAAATTACAACATCAAAACCAGGAATGTCCCCGCATCTACTATTACC
AGGCTTGCAATTGGTTCAATTTTCCCATAAAAACATGTTTGTCCAAAAGAAGGGAAACTGTGAATTTATTCCATGCATGTAATAAACTCT
GCAAGAAGTTTAACCCACATAGGTTTGCGGCACTGCAAAATTGTTCATGGGTCTATGTAGCAAATGATTCTCTGCCTTGACAATCATGTA

>64842_64842_3_PHF21A-CAMK1D_PHF21A_chr11_46098305_ENST00000418153_CAMK1D_chr10_12811672_ENST00000378847_length(amino acids)=290AA_BP=51
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP
GYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAAR
HPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSG

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Fusion Gene PPI Analysis for PHF21A-CAMK1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF21A-CAMK1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF21A-CAMK1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource