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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF23-TOM1 (FusionGDB2 ID:64864)

Fusion Gene Summary for PHF23-TOM1

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF23-TOM1
Fusion gene ID: 64864
HgeneTgene
Gene symbol

PHF23

TOM1

Gene ID

79142

10043

Gene namePHD finger protein 23target of myb1 membrane trafficking protein
SynonymshJUNE-1b-
Cytomap

17p13.1

22q12.3

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 23PDH-containing protein JUNE-1PHD finger protein 23atarget of Myb protein 1target of myb 1
Modification date2020031320200313
UniProtAcc.

TOM1L2

Ensembl transtripts involved in fusion geneENST00000320316, ENST00000571362, 
ENST00000576955, ENST00000454255, 
ENST00000570753, 		ENST00000382034, 
ENST00000411850, ENST00000425375, 
ENST00000436462, ENST00000447733, 
ENST00000449058, 
Fusion gene scores* DoF score2 X 2 X 2=812 X 10 X 7=840
# samples 215
** MAII scorelog2(2/8*10)=1.32192809488736log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF23 [Title/Abstract] AND TOM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF23(7142565)-TOM1(35741718), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PHF23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TOM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-ZS-A9CD-01APHF23chr17

7142565

-TOM1chr22

35741718

+


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Fusion Gene ORF analysis for PHF23-TOM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000320316ENST00000382034PHF23chr17

7142565

-TOM1chr22

35741718

+
5CDS-3UTRENST00000571362ENST00000382034PHF23chr17

7142565

-TOM1chr22

35741718

+
5UTR-3CDSENST00000576955ENST00000411850PHF23chr17

7142565

-TOM1chr22

35741718

+
5UTR-3CDSENST00000576955ENST00000425375PHF23chr17

7142565

-TOM1chr22

35741718

+
5UTR-3CDSENST00000576955ENST00000436462PHF23chr17

7142565

-TOM1chr22

35741718

+
5UTR-3CDSENST00000576955ENST00000447733PHF23chr17

7142565

-TOM1chr22

35741718

+
5UTR-3CDSENST00000576955ENST00000449058PHF23chr17

7142565

-TOM1chr22

35741718

+
5UTR-3UTRENST00000576955ENST00000382034PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000320316ENST00000411850PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000320316ENST00000425375PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000320316ENST00000436462PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000320316ENST00000447733PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000320316ENST00000449058PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000571362ENST00000411850PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000571362ENST00000425375PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000571362ENST00000436462PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000571362ENST00000447733PHF23chr17

7142565

-TOM1chr22

35741718

+
In-frameENST00000571362ENST00000449058PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000454255ENST00000411850PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000454255ENST00000425375PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000454255ENST00000436462PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000454255ENST00000447733PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000454255ENST00000449058PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000570753ENST00000411850PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000570753ENST00000425375PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000570753ENST00000436462PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000570753ENST00000447733PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3CDSENST00000570753ENST00000449058PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3UTRENST00000454255ENST00000382034PHF23chr17

7142565

-TOM1chr22

35741718

+
intron-3UTRENST00000570753ENST00000382034PHF23chr17

7142565

-TOM1chr22

35741718

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000320316PHF23chr177142565-ENST00000447733TOM1chr2235741718+13022611107568179
ENST00000320316PHF23chr177142565-ENST00000449058TOM1chr2235741718+12942611104565179
ENST00000320316PHF23chr177142565-ENST00000425375TOM1chr2235741718+12992611104565179
ENST00000320316PHF23chr177142565-ENST00000411850TOM1chr2235741718+13022611107568179
ENST00000320316PHF23chr177142565-ENST00000436462TOM1chr2235741718+1005261538104144
ENST00000571362PHF23chr177142565-ENST00000447733TOM1chr2235741718+12351941040501179
ENST00000571362PHF23chr177142565-ENST00000449058TOM1chr2235741718+12271941037498179
ENST00000571362PHF23chr177142565-ENST00000425375TOM1chr2235741718+12321941037498179
ENST00000571362PHF23chr177142565-ENST00000411850TOM1chr2235741718+12351941040501179
ENST00000571362PHF23chr177142565-ENST00000436462TOM1chr2235741718+93819447137144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000320316ENST00000447733PHF23chr177142565-TOM1chr2235741718+0.308570560.69142944
ENST00000320316ENST00000449058PHF23chr177142565-TOM1chr2235741718+0.28141210.7185879
ENST00000320316ENST00000425375PHF23chr177142565-TOM1chr2235741718+0.29022190.70977813
ENST00000320316ENST00000411850PHF23chr177142565-TOM1chr2235741718+0.308570560.69142944
ENST00000320316ENST00000436462PHF23chr177142565-TOM1chr2235741718+0.387776230.61222374
ENST00000571362ENST00000447733PHF23chr177142565-TOM1chr2235741718+0.380479630.61952037
ENST00000571362ENST00000449058PHF23chr177142565-TOM1chr2235741718+0.51393930.48606065
ENST00000571362ENST00000425375PHF23chr177142565-TOM1chr2235741718+0.526172040.473828
ENST00000571362ENST00000411850PHF23chr177142565-TOM1chr2235741718+0.380479630.61952037
ENST00000571362ENST00000436462PHF23chr177142565-TOM1chr2235741718+0.68509930.3149007

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Fusion Genomic Features for PHF23-TOM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PHF23chr177142564-TOM1chr2235741717+3.45E-050.99996555
PHF23chr177142564-TOM1chr2235741717+3.45E-050.99996555

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PHF23-TOM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:7142565/chr22:35741718)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TOM1

TOM1L2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.507

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF23chr17:7142565chr22:35741718ENST00000320316-15248_26111404.0Compositional biasNote=Poly-Glu
HgenePHF23chr17:7142565chr22:35741718ENST00000320316-15339_38711404.0Zinc fingerNote=PHD-type
TgeneTOM1chr17:7142565chr22:35741718ENST00000411850111520_152408494.0DomainVHS
TgeneTOM1chr17:7142565chr22:35741718ENST000004118501115215_303408494.0DomainGAT
TgeneTOM1chr17:7142565chr22:35741718ENST00000425375101420_152363448.0DomainVHS
TgeneTOM1chr17:7142565chr22:35741718ENST000004253751014215_303363448.0DomainGAT
TgeneTOM1chr17:7142565chr22:35741718ENST00000447733111520_152375461.0DomainVHS
TgeneTOM1chr17:7142565chr22:35741718ENST000004477331115215_303375461.0DomainGAT
TgeneTOM1chr17:7142565chr22:35741718ENST00000449058111520_152408493.0DomainVHS
TgeneTOM1chr17:7142565chr22:35741718ENST000004490581115215_303408493.0DomainGAT


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Fusion Gene Sequence for PHF23-TOM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64864_64864_1_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000411850_length(transcript)=1302nt_BP=261nt
AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT
AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC
CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC
ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA
GGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGT
CCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGC
AGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCC
CCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGC
AGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGC
TGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACAC
TGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATG
GCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGTACGAAGCTGCAACTCTGCGC
GCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCCCTCCGCTGCCTTGCCCTCCA
TCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACTGGGAGAGGTGCCTTTTGTAT

>64864_64864_1_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000411850_length(amino acids)=179AA_BP=
MGLMRSRPLRAELQLRTWAAAAPQGASTPPHPTLSGQPKPWGPMQQSREGTRGSAEFPLWPASSQASTGSVGSEGLLGAWARSRVSLSEG

--------------------------------------------------------------
>64864_64864_2_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000425375_length(transcript)=1299nt_BP=261nt
AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT
AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC
CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC
ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA
GAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCC
CCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGCAGC
CCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCCCCT
TTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGCAGT
GGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGCTGG
CTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACACTGC
CAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATGGCT
TTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGTACGAAGCTGCAACTCTGCGCGCA
GTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCCCTCCGCTGCCTTGCCCTCCATCC
TTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACTGGGAGAGGTGCCTTTTGTATCCC

>64864_64864_2_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000425375_length(amino acids)=179AA_BP=
MGLMRSRPLRAELQLRTWAAAAPQGASTPPHPTLSGQPKPWGPMQQSREGTRGSAEFPLWPASSQASTGSVGSEGLLGAWARSRVSLSEG

--------------------------------------------------------------
>64864_64864_3_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000436462_length(transcript)=1005nt_BP=261nt
AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT
AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC
CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC
ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA
GAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCC
CCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGCAGC
CCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCCCCT
TTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGCAGT
GGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGCTGG
CTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACACTGC
CAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATGGCT

>64864_64864_3_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000436462_length(amino acids)=144AA_BP=1
MQGARPHTHKANSMSSSFSWVFFRGAGPDGGPGGPSAEGLERLGNRSAALARSSRNLSNSSLVTPLGSSASLPTSVDSHCSMSSMRQAWV

--------------------------------------------------------------
>64864_64864_4_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000447733_length(transcript)=1302nt_BP=261nt
AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT
AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC
CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC
ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA
GGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGT
CCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGC
AGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCC
CCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGC
AGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGC
TGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACAC
TGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATG
GCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGTACGAAGCTGCAACTCTGCGC
GCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCCCTCCGCTGCCTTGCCCTCCA
TCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACTGGGAGAGGTGCCTTTTGTAT

>64864_64864_4_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000447733_length(amino acids)=179AA_BP=
MGLMRSRPLRAELQLRTWAAAAPQGASTPPHPTLSGQPKPWGPMQQSREGTRGSAEFPLWPASSQASTGSVGSEGLLGAWARSRVSLSEG

--------------------------------------------------------------
>64864_64864_5_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000449058_length(transcript)=1294nt_BP=261nt
AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT
AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC
CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC
ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA
GAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCC
CCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGCAGC
CCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCCCCT
TTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGCAGT
GGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGCTGG
CTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACACTGC
CAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATGGCT
TTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGTACGAAGCTGCAACTCTGCGCGCA
GTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCCCTCCGCTGCCTTGCCCTCCATCC
TTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACTGGGAGAGGTGCCTTTTGTATCCC

>64864_64864_5_PHF23-TOM1_PHF23_chr17_7142565_ENST00000320316_TOM1_chr22_35741718_ENST00000449058_length(amino acids)=179AA_BP=
MGLMRSRPLRAELQLRTWAAAAPQGASTPPHPTLSGQPKPWGPMQQSREGTRGSAEFPLWPASSQASTGSVGSEGLLGAWARSRVSLSEG

--------------------------------------------------------------
>64864_64864_6_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000411850_length(transcript)=1235nt_BP=194nt
AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG
CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA
GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG
AGCCTAAGGGGGTCACCAGCGAAGGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCC
CCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTAT
GAGTGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCT
GCTTTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGA
ACTGGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGA
GGCCCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCC
AAGGAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCT
GCTCTGCTGCATGGGGCCCCATGGCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCA
GGTACGAAGCTGCAACTCTGCGCGCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTG
CCCCTCCGCTGCCTTGCCCTCCATCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGT

>64864_64864_6_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000411850_length(amino acids)=179AA_BP=
MGLMRSRPLRAELQLRTWAAAAPQGASTPPHPTLSGQPKPWGPMQQSREGTRGSAEFPLWPASSQASTGSVGSEGLLGAWARSRVSLSEG

--------------------------------------------------------------
>64864_64864_7_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000425375_length(transcript)=1232nt_BP=194nt
AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG
CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA
GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG
AGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCT
CAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAG
TGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCT
TTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACT
GGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGC
CCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAG
GAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCT
CTGCTGCATGGGGCCCCATGGCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGT
ACGAAGCTGCAACTCTGCGCGCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCC
CTCCGCTGCCTTGCCCTCCATCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACT

>64864_64864_7_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000425375_length(amino acids)=179AA_BP=
MGLMRSRPLRAELQLRTWAAAAPQGASTPPHPTLSGQPKPWGPMQQSREGTRGSAEFPLWPASSQASTGSVGSEGLLGAWARSRVSLSEG

--------------------------------------------------------------
>64864_64864_8_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000436462_length(transcript)=938nt_BP=194nt
AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG
CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA
GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG
AGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCT
CAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAG
TGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCT
TTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACT
GGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGC
CCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAG
GAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCT

>64864_64864_8_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000436462_length(amino acids)=144AA_BP=1
MQGARPHTHKANSMSSSFSWVFFRGAGPDGGPGGPSAEGLERLGNRSAALARSSRNLSNSSLVTPLGSSASLPTSVDSHCSMSSMRQAWV

--------------------------------------------------------------
>64864_64864_9_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000447733_length(transcript)=1235nt_BP=194nt
AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG
CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA
GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG
AGCCTAAGGGGGTCACCAGCGAAGGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCC
CCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTAT
GAGTGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCT
GCTTTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGA
ACTGGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGA
GGCCCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCC
AAGGAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCT
GCTCTGCTGCATGGGGCCCCATGGCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCA
GGTACGAAGCTGCAACTCTGCGCGCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTG
CCCCTCCGCTGCCTTGCCCTCCATCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGT

>64864_64864_9_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000447733_length(amino acids)=179AA_BP=
MGLMRSRPLRAELQLRTWAAAAPQGASTPPHPTLSGQPKPWGPMQQSREGTRGSAEFPLWPASSQASTGSVGSEGLLGAWARSRVSLSEG

--------------------------------------------------------------
>64864_64864_10_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000449058_length(transcript)=1227nt_BP=194nt
AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG
CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA
GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG
AGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCT
CAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAG
TGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCT
TTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACT
GGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGC
CCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAG
GAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCT
CTGCTGCATGGGGCCCCATGGCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGT
ACGAAGCTGCAACTCTGCGCGCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCC
CTCCGCTGCCTTGCCCTCCATCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACT

>64864_64864_10_PHF23-TOM1_PHF23_chr17_7142565_ENST00000571362_TOM1_chr22_35741718_ENST00000449058_length(amino acids)=179AA_BP=
MGLMRSRPLRAELQLRTWAAAAPQGASTPPHPTLSGQPKPWGPMQQSREGTRGSAEFPLWPASSQASTGSVGSEGLLGAWARSRVSLSEG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PHF23-TOM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF23-TOM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF23-TOM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource