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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHF2-MRGPRF (FusionGDB2 ID:64870)

Fusion Gene Summary for PHF2-MRGPRF

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF2-MRGPRF
Fusion gene ID: 64870
HgeneTgene
Gene symbol

PHF2

MRGPRF

Gene ID

5253

116535

Gene namePHD finger protein 2MAS related GPR family member F
SynonymsCENP-35|GRC5|JHDM1E|KDM7CGPR140|GPR168|MRGF|RTA
Cytomap

9q22.31

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase PHF2centromere protein 35jumonji C domain-containing histone demethylase 1Emas-related G-protein coupled receptor member FG protein-coupled receptor MrgFG-protein coupled receptor 140G-protein coupled receptor 168MAS-related GPR, member FMas-related G protein-coupled receptor Fmas-related G protein-coupled MRGFmas-related
Modification date2020031320200313
UniProtAcc.

Q96AM1

Ensembl transtripts involved in fusion geneENST00000359246, ENST00000375376, 
ENST00000320913, ENST00000309099, 
ENST00000441623, 
Fusion gene scores* DoF score10 X 6 X 6=3604 X 3 X 4=48
# samples 104
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF2 [Title/Abstract] AND MRGPRF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHF2(96435888)-MRGPRF(68772803), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHF2

GO:0006482

protein demethylation

21532585


check buttonFusion gene breakpoints across PHF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRGPRF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AFN057836PHF2chr9

96435888

+MRGPRFchr11

68772803

+


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Fusion Gene ORF analysis for PHF2-MRGPRF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000359246ENST00000320913PHF2chr9

96435888

+MRGPRFchr11

68772803

+
In-frameENST00000359246ENST00000309099PHF2chr9

96435888

+MRGPRFchr11

68772803

+
In-frameENST00000359246ENST00000441623PHF2chr9

96435888

+MRGPRFchr11

68772803

+
intron-3CDSENST00000375376ENST00000309099PHF2chr9

96435888

+MRGPRFchr11

68772803

+
intron-3CDSENST00000375376ENST00000441623PHF2chr9

96435888

+MRGPRFchr11

68772803

+
intron-intronENST00000375376ENST00000320913PHF2chr9

96435888

+MRGPRFchr11

68772803

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359246PHF2chr996435888+ENST00000441623MRGPRFchr1168772803+391229711782883901
ENST00000359246PHF2chr996435888+ENST00000309099MRGPRFchr1168772803+390929711782883901

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359246ENST00000441623PHF2chr996435888+MRGPRFchr1168772803+0.0026596620.9973404
ENST00000359246ENST00000309099PHF2chr996435888+MRGPRFchr1168772803+0.0026242750.9973757

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Fusion Genomic Features for PHF2-MRGPRF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHF2-MRGPRF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:96435888/chr11:68772803)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MRGPRF

Q96AM1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903105_1230344.0Topological domainExtracellular
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903145_1600344.0Topological domainCytoplasmic
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903182_1980344.0Topological domainExtracellular
TgeneMRGPRFchr9:96435888chr11:68772803ENST00000309099031_440344.0Topological domainExtracellular
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903221_2410344.0Topological domainCytoplasmic
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903264_2730344.0Topological domainExtracellular
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903295_3430344.0Topological domainCytoplasmic
TgeneMRGPRFchr9:96435888chr11:68772803ENST000003090990367_820344.0Topological domainCytoplasmic
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303105_1230344.0Topological domainExtracellular
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303145_1600344.0Topological domainCytoplasmic
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303182_1980344.0Topological domainExtracellular
TgeneMRGPRFchr9:96435888chr11:68772803ENST00000441623031_440344.0Topological domainExtracellular
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303221_2410344.0Topological domainCytoplasmic
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303264_2730344.0Topological domainExtracellular
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303295_3430344.0Topological domainCytoplasmic
TgeneMRGPRFchr9:96435888chr11:68772803ENST000004416230367_820344.0Topological domainCytoplasmic
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903124_1440344.0TransmembraneHelical%3B Name%3D3
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903161_1810344.0TransmembraneHelical%3B Name%3D4
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903199_2200344.0TransmembraneHelical%3B Name%3D5
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903242_2630344.0TransmembraneHelical%3B Name%3D6
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000030909903274_2940344.0TransmembraneHelical%3B Name%3D7
TgeneMRGPRFchr9:96435888chr11:68772803ENST000003090990345_660344.0TransmembraneHelical%3B Name%3D1
TgeneMRGPRFchr9:96435888chr11:68772803ENST000003090990383_1040344.0TransmembraneHelical%3B Name%3D2
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303124_1440344.0TransmembraneHelical%3B Name%3D3
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303161_1810344.0TransmembraneHelical%3B Name%3D4
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303199_2200344.0TransmembraneHelical%3B Name%3D5
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303242_2630344.0TransmembraneHelical%3B Name%3D6
TgeneMRGPRFchr9:96435888chr11:68772803ENST0000044162303274_2940344.0TransmembraneHelical%3B Name%3D7
TgeneMRGPRFchr9:96435888chr11:68772803ENST000004416230345_660344.0TransmembraneHelical%3B Name%3D1
TgeneMRGPRFchr9:96435888chr11:68772803ENST000004416230383_1040344.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHF2chr9:96435888chr11:68772803ENST00000359246+122472_51801097.0Compositional biasNote=Pro-rich
HgenePHF2chr9:96435888chr11:68772803ENST00000359246+122487_64801097.0Compositional biasNote=Lys-rich
HgenePHF2chr9:96435888chr11:68772803ENST00000359246+122960_102001097.0Compositional biasNote=Ser/Thr-rich
HgenePHF2chr9:96435888chr11:68772803ENST00000359246+122197_35301097.0DomainJmjC
HgenePHF2chr9:96435888chr11:68772803ENST00000359246+1225_5601097.0Zinc fingerPHD-type


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Fusion Gene Sequence for PHF2-MRGPRF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64870_64870_1_PHF2-MRGPRF_PHF2_chr9_96435888_ENST00000359246_MRGPRF_chr11_68772803_ENST00000309099_length(transcript)=3909nt_BP=2971nt
GGCCGCTCGGCGGCCGGGGGTCCCTTCGGTGGGGCCGCGGCTCCCCGCCCGCCGCCCCCGCGCGTCCATTCCCTTTTGTGTCCCGCGCGC
GGCCCGTCCCCCGCGCACACTAGCGCCCTGAGCCCCGCGGGCCGGCGGGCGGCTCCCGGCGCGGCCCCTCCAGCCAGCGCGCCCGGCATT
GTGTGGACGCGCCTGGCCGGGAGCGCGCGCGGGGGCTGTCGTGCGCCCCCGTCCCCGTCCCCTCCCGGCCGCGGCGCCGCCTGCGCCCCG
CCGCCCCCGCCGCCCCCGCGCGGCCCGGCCCCCGGCCCGGCCCGGACCGACCCGGGCAGCGCAGCGGCGGGGCCGAGCGGCGGCGCGGCG
CGGCAACATGGCGACGGTGCCCGTGTACTGCGTCTGCCGGCTCCCCTACGACGTTACCCGCTTCATGATCGAGTGCGACGCCTGCAAGGA
CTGGTTCCACGGCAGCTGTGTTGGGGTGGAAGAGGAGGAGGCGCCCGACATCGACATATACCACTGCCCAAACTGTGAGAAAACCCATGG
GAAGTCCACCTTAAAGAAGAAGCGGACCTGGCACAAACACGGCCCGGGGCAAGCGCCTGACGTCAAGCCCGTGCAGAATGGCAGCCAGCT
CTTCATCAAGGAGCTGCGGAGCCGGACCTTTCCCAGTGCTGAAGACGTGGTGGCCCGTGTGCCAGGAAGTCAGCTCACGCTGGGCTACAT
GGAGGAGCACGGCTTCACCGAGCCCATCCTCGTCCCTAAGAAAGACGGGCTGGGTCTGGCTGTCCCGGCCCCCACGTTCTATGTCAGTGA
CGTCGAGAACTACGTGGGGCCGGAACGGAGTGTGGATGTGACAGATGTCACCAAGCAGAAGGACTGCAAGATGAAGCTGAAGGAGTTTGT
GGACTATTACTACAGCACCAACCGCAAGCGGGTCCTCAACGTCACCAACCTCGAGTTCTCTGACACCCGAATGTCCAGCTTCGTGGAGCC
ACCTGACATTGTAAAGAAACTGTCATGGGTAGAAAACTACTGGCCAGATGATGCATTGCTGGCCAAGCCCAAAGTGACCAAGTACTGCCT
AATCTGCGTGAAGGACAGTTACACCGACTTCCACATCGACTCTGGGGGCGCCTCTGCCTGGTACCACGTGCTCAAGGGGGAGAAGACCTT
CTATCTCATCAGGCCGGCCTCGGCCAACATCTCCCTGTATGAGCGCTGGCGGTCTGCCTCTAACCACAGCGAGATGTTCTTTGCTGACCA
GGTCGACAAATGCTACAAGTGCATCGTCAAGCAGGGCCAGACCCTCTTCATCCCCTCAGGCTGGATCTACGCCACACTCACCCCTGTGGA
CTGCCTGGCCTTCGCGGGACATTTCCTCCACAGCCTGAGTGTGGAGATGCAGATGAGAGCATATGAAGTGGAAAGGAGGTTGAAACTGGG
CAGCCTGACTCAGTTTCCCAACTTTGAAACTGCGTGCTGGTACATGGGGAAGCACCTGCTGGAGGCATTCAAAGGCTCTCACAAATCTGG
GAAGCAGCTGCCCCCTCATCTAGTCCAAGGAGCTAAAATTCTCAATGGTGCTTTCCGATCGTGGACGAAGAAGCAGGCTTTGGCAGAGCA
TGAGGACGAGCTCCCGGAGCACTTCAAACCTTCACAGCTAATCAAAGACCTGGCCAAAGAGATCCGGCTCAGTGAGAATGCCTCCAAAGC
CGTCCGACCGGAAGTGAATACTGTCGCCTCGTCAGATGAGGTGTGTGACGGGGACCGGGAGAAGGAGGAGCCCCCGTCTCCCATTGAGGC
CACCCCGCCTCAATCCCTCCTGGAGAAAGTGTCCAAAAAAAAGACTCCCAAAACTGTGAAGATGCCCAAGCCATCCAAAATCCCCAAGCC
CCCGAAGCCCCCTAAGCCCCCAAGGCCCCCCAAAACGCTGAAGCTCAAAGATGGAGGCAAGAAGAAAGGGAAGAAGTCCCGGGAGTCAGC
CTCACCCACCATCCCCAACCTGGACCTGCTCGAAGCCCACACCAAGGAGGCACTGACCAAGATGGAGCCGCCCAAGAAGGGCAAGGCCAC
AAAGAGTGTCCTGAGTGTGCCCAACAAAGATGTGGTTCACATGCAGAATGATGTGGAGAGGCTGGAAATTCGAGAGCAAACCAAGAGCAA
GTCAGAGGCCAAGTGGAAGTACAAGAACAGCAAACCTGACTCCTTACTGAAGATGGAAGAGGAGCAGAAGCTAGAGAAGTCGCCTCTAGC
TGGAAACAAAGACAATAAGTTCTCTTTTTCTTTCTCCAACAAGAAACTCCTCGGCTCCAAGGCTCTCAGGCCCCCGACGAGCCCTGGTGT
GTTCGGGGCCTTGCAGAACTTCAAGGAGGACAAGCCCAAGCCCGTGCGGGATGAGTATGAGTACGTGTCGGATGACGGTGAGCTCAAGAT
CGACGAGTTTCCCATCAGGAGGAAGAAAAACGCCCCGAAAAGGGACTTGTCCTTCTTGTTGGATAAGAAGGCTGTGCTGCCCACGCCTGT
CACGAAGCCAAAGCTGGACTCGGCAGCGTACAAGAGTGATGACTCCTCGGACGAGGGTTCGCTGCACATCGACACAGACACCAAGCCCGG
CCGCAATGCCAGAGTCAAGAAGGAGAGTGGGAGCTCGGCAGCTGGCATCTTGGACCTGCTGCAGGCCAGTGAGGAGGTTGGCGCGCTGGA
GTACAACCCCAGCAGACACAGGAAGCCATTCAGGGAATGCTGTCCATGGCCAACCTGCAGGCCTCCGACTCCTGCCTGCAGACCACGTGG
GGAGCTGGCCAGGCCAAGGGGAGCTCGCTGGCTGCCCATGGTGCCCGGAAGAATGGGGGTGGCAGTGGCAAGAGTGCAGGCAAACGACTG
CTGAAGAGGGCTGCCAAGAACAGTGTCGACCTGGACGACTACGAGGAAGAGCAGGACCACCTGGATGCCTGCTTCAAGGACTCAGACTAC
GCAGCACGCCCAACACAGTCACCATGGAGATGCAGTGTCCCCCGGGGAACGCCTCCTGAGACTCCAGCGCCTGGAGGAGGCAGGGGCAGG
AAGCGGCCTCCAAGACCCTTCGCCTTGGGACAGGAATGGGCACCTGCTTCTGAGTCCATACAGGAGAAGAAAGATCTGTTTCCTCTCCTC
GGGCCTCCTTCTCCCTGGGCTGGGGACTCCAGGGGTGGCTGGGAGACTGGGCAGCCACCAGCAAACAGACCCTGTGGCCCCTGCCCGGCT
CCCCCACCCATTCTGCTCCCCTAGAGACCTCTTGTACAGAAGTTGCCCCCAGGTGGTGGGGCCCCTCCTTGCCCTAGGCTGGTTGGTAAA
AGAGAGGAGGTCAACACCCAGCCTAGCCACCTCTGCCTCTTGGGTCAGCCCTCCTTGACTGTGTCCCAGCCAGCACCAGGCCAGCAGCCT
CATCCCTGCCATTCAGGGCTGTTCCAGAGATTCGATCCTCTTAAGGCATTATCAGTGAGCAAATGTGAAGGAAATGGTGTCTGGAAGAAA
GTTCTGGTTCACATGCCTTGTAGCTAAGTCTTTCTGCAAACAACCTCCCTTCCCCCCGTCGAGTCATTTGGTGACTTTGATGGGGGGATT
TCTGGTTATGTCAAGGCTCTGGAGACAGGAAGGGCCTTTGGCCGCCTTGGGTAGTTGACCTGCCTTTTCTGACTCCGGGACGAGCCAGTC
CTAGGCTGCCTCCGGGAGCACTTGAGGTATCCCGCAGGCCATGAGGACCCACTGGGCAGCTCCTGGACAGCCTCTTGGCTCCAGCCCCCA
CCCGAAAGTGGACACTGGCTCCGCCCTGGCCACCTGGGGACTGGCACTGTGGTGCACAGTGGCCCAATGTGGCCAACGGAAGTTTTATAA

>64870_64870_1_PHF2-MRGPRF_PHF2_chr9_96435888_ENST00000359246_MRGPRF_chr11_68772803_ENST00000309099_length(amino acids)=901AA_BP=
MCGRAWPGARAGAVVRPRPRPLPAAAPPAPRRPRRPRAARPPARPGPTRAAQRRGRAAARRGNMATVPVYCVCRLPYDVTRFMIECDACK
DWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGY
MEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVE
PPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFAD
QVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKS
GKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIE
ATPPQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGKA
TKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPG
VFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKP
GRNARVKKESGSSAAGILDLLQASEEVGALEYNPSRHRKPFRECCPWPTCRPPTPACRPRGELARPRGARWLPMVPGRMGVAVARVQAND

--------------------------------------------------------------
>64870_64870_2_PHF2-MRGPRF_PHF2_chr9_96435888_ENST00000359246_MRGPRF_chr11_68772803_ENST00000441623_length(transcript)=3912nt_BP=2971nt
GGCCGCTCGGCGGCCGGGGGTCCCTTCGGTGGGGCCGCGGCTCCCCGCCCGCCGCCCCCGCGCGTCCATTCCCTTTTGTGTCCCGCGCGC
GGCCCGTCCCCCGCGCACACTAGCGCCCTGAGCCCCGCGGGCCGGCGGGCGGCTCCCGGCGCGGCCCCTCCAGCCAGCGCGCCCGGCATT
GTGTGGACGCGCCTGGCCGGGAGCGCGCGCGGGGGCTGTCGTGCGCCCCCGTCCCCGTCCCCTCCCGGCCGCGGCGCCGCCTGCGCCCCG
CCGCCCCCGCCGCCCCCGCGCGGCCCGGCCCCCGGCCCGGCCCGGACCGACCCGGGCAGCGCAGCGGCGGGGCCGAGCGGCGGCGCGGCG
CGGCAACATGGCGACGGTGCCCGTGTACTGCGTCTGCCGGCTCCCCTACGACGTTACCCGCTTCATGATCGAGTGCGACGCCTGCAAGGA
CTGGTTCCACGGCAGCTGTGTTGGGGTGGAAGAGGAGGAGGCGCCCGACATCGACATATACCACTGCCCAAACTGTGAGAAAACCCATGG
GAAGTCCACCTTAAAGAAGAAGCGGACCTGGCACAAACACGGCCCGGGGCAAGCGCCTGACGTCAAGCCCGTGCAGAATGGCAGCCAGCT
CTTCATCAAGGAGCTGCGGAGCCGGACCTTTCCCAGTGCTGAAGACGTGGTGGCCCGTGTGCCAGGAAGTCAGCTCACGCTGGGCTACAT
GGAGGAGCACGGCTTCACCGAGCCCATCCTCGTCCCTAAGAAAGACGGGCTGGGTCTGGCTGTCCCGGCCCCCACGTTCTATGTCAGTGA
CGTCGAGAACTACGTGGGGCCGGAACGGAGTGTGGATGTGACAGATGTCACCAAGCAGAAGGACTGCAAGATGAAGCTGAAGGAGTTTGT
GGACTATTACTACAGCACCAACCGCAAGCGGGTCCTCAACGTCACCAACCTCGAGTTCTCTGACACCCGAATGTCCAGCTTCGTGGAGCC
ACCTGACATTGTAAAGAAACTGTCATGGGTAGAAAACTACTGGCCAGATGATGCATTGCTGGCCAAGCCCAAAGTGACCAAGTACTGCCT
AATCTGCGTGAAGGACAGTTACACCGACTTCCACATCGACTCTGGGGGCGCCTCTGCCTGGTACCACGTGCTCAAGGGGGAGAAGACCTT
CTATCTCATCAGGCCGGCCTCGGCCAACATCTCCCTGTATGAGCGCTGGCGGTCTGCCTCTAACCACAGCGAGATGTTCTTTGCTGACCA
GGTCGACAAATGCTACAAGTGCATCGTCAAGCAGGGCCAGACCCTCTTCATCCCCTCAGGCTGGATCTACGCCACACTCACCCCTGTGGA
CTGCCTGGCCTTCGCGGGACATTTCCTCCACAGCCTGAGTGTGGAGATGCAGATGAGAGCATATGAAGTGGAAAGGAGGTTGAAACTGGG
CAGCCTGACTCAGTTTCCCAACTTTGAAACTGCGTGCTGGTACATGGGGAAGCACCTGCTGGAGGCATTCAAAGGCTCTCACAAATCTGG
GAAGCAGCTGCCCCCTCATCTAGTCCAAGGAGCTAAAATTCTCAATGGTGCTTTCCGATCGTGGACGAAGAAGCAGGCTTTGGCAGAGCA
TGAGGACGAGCTCCCGGAGCACTTCAAACCTTCACAGCTAATCAAAGACCTGGCCAAAGAGATCCGGCTCAGTGAGAATGCCTCCAAAGC
CGTCCGACCGGAAGTGAATACTGTCGCCTCGTCAGATGAGGTGTGTGACGGGGACCGGGAGAAGGAGGAGCCCCCGTCTCCCATTGAGGC
CACCCCGCCTCAATCCCTCCTGGAGAAAGTGTCCAAAAAAAAGACTCCCAAAACTGTGAAGATGCCCAAGCCATCCAAAATCCCCAAGCC
CCCGAAGCCCCCTAAGCCCCCAAGGCCCCCCAAAACGCTGAAGCTCAAAGATGGAGGCAAGAAGAAAGGGAAGAAGTCCCGGGAGTCAGC
CTCACCCACCATCCCCAACCTGGACCTGCTCGAAGCCCACACCAAGGAGGCACTGACCAAGATGGAGCCGCCCAAGAAGGGCAAGGCCAC
AAAGAGTGTCCTGAGTGTGCCCAACAAAGATGTGGTTCACATGCAGAATGATGTGGAGAGGCTGGAAATTCGAGAGCAAACCAAGAGCAA
GTCAGAGGCCAAGTGGAAGTACAAGAACAGCAAACCTGACTCCTTACTGAAGATGGAAGAGGAGCAGAAGCTAGAGAAGTCGCCTCTAGC
TGGAAACAAAGACAATAAGTTCTCTTTTTCTTTCTCCAACAAGAAACTCCTCGGCTCCAAGGCTCTCAGGCCCCCGACGAGCCCTGGTGT
GTTCGGGGCCTTGCAGAACTTCAAGGAGGACAAGCCCAAGCCCGTGCGGGATGAGTATGAGTACGTGTCGGATGACGGTGAGCTCAAGAT
CGACGAGTTTCCCATCAGGAGGAAGAAAAACGCCCCGAAAAGGGACTTGTCCTTCTTGTTGGATAAGAAGGCTGTGCTGCCCACGCCTGT
CACGAAGCCAAAGCTGGACTCGGCAGCGTACAAGAGTGATGACTCCTCGGACGAGGGTTCGCTGCACATCGACACAGACACCAAGCCCGG
CCGCAATGCCAGAGTCAAGAAGGAGAGTGGGAGCTCGGCAGCTGGCATCTTGGACCTGCTGCAGGCCAGTGAGGAGGTTGGCGCGCTGGA
GTACAACCCCAGCAGACACAGGAAGCCATTCAGGGAATGCTGTCCATGGCCAACCTGCAGGCCTCCGACTCCTGCCTGCAGACCACGTGG
GGAGCTGGCCAGGCCAAGGGGAGCTCGCTGGCTGCCCATGGTGCCCGGAAGAATGGGGGTGGCAGTGGCAAGAGTGCAGGCAAACGACTG
CTGAAGAGGGCTGCCAAGAACAGTGTCGACCTGGACGACTACGAGGAAGAGCAGGACCACCTGGATGCCTGCTTCAAGGACTCAGACTAC
GCAGCACGCCCAACACAGTCACCATGGAGATGCAGTGTCCCCCGGGGAACGCCTCCTGAGACTCCAGCGCCTGGAGGAGGCAGGGGCAGG
AAGCGGCCTCCAAGACCCTTCGCCTTGGGACAGGAATGGGCACCTGCTTCTGAGTCCATACAGGAGAAGAAAGATCTGTTTCCTCTCCTC
GGGCCTCCTTCTCCCTGGGCTGGGGACTCCAGGGGTGGCTGGGAGACTGGGCAGCCACCAGCAAACAGACCCTGTGGCCCCTGCCCGGCT
CCCCCACCCATTCTGCTCCCCTAGAGACCTCTTGTACAGAAGTTGCCCCCAGGTGGTGGGGCCCCTCCTTGCCCTAGGCTGGTTGGTAAA
AGAGAGGAGGTCAACACCCAGCCTAGCCACCTCTGCCTCTTGGGTCAGCCCTCCTTGACTGTGTCCCAGCCAGCACCAGGCCAGCAGCCT
CATCCCTGCCATTCAGGGCTGTTCCAGAGATTCGATCCTCTTAAGGCATTATCAGTGAGCAAATGTGAAGGAAATGGTGTCTGGAAGAAA
GTTCTGGTTCACATGCCTTGTAGCTAAGTCTTTCTGCAAACAACCTCCCTTCCCCCCGTCGAGTCATTTGGTGACTTTGATGGGGGGATT
TCTGGTTATGTCAAGGCTCTGGAGACAGGAAGGGCCTTTGGCCGCCTTGGGTAGTTGACCTGCCTTTTCTGACTCCGGGACGAGCCAGTC
CTAGGCTGCCTCCGGGAGCACTTGAGGTATCCCGCAGGCCATGAGGACCCACTGGGCAGCTCCTGGACAGCCTCTTGGCTCCAGCCCCCA
CCCGAAAGTGGACACTGGCTCCGCCCTGGCCACCTGGGGACTGGCACTGTGGTGCACAGTGGCCCAATGTGGCCAACGGAAGTTTTATAA

>64870_64870_2_PHF2-MRGPRF_PHF2_chr9_96435888_ENST00000359246_MRGPRF_chr11_68772803_ENST00000441623_length(amino acids)=901AA_BP=
MCGRAWPGARAGAVVRPRPRPLPAAAPPAPRRPRRPRAARPPARPGPTRAAQRRGRAAARRGNMATVPVYCVCRLPYDVTRFMIECDACK
DWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGY
MEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVE
PPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFAD
QVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKS
GKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIE
ATPPQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGKA
TKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPG
VFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKP
GRNARVKKESGSSAAGILDLLQASEEVGALEYNPSRHRKPFRECCPWPTCRPPTPACRPRGELARPRGARWLPMVPGRMGVAVARVQAND

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Fusion Gene PPI Analysis for PHF2-MRGPRF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHF2-MRGPRF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHF2-MRGPRF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource