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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARID5A-CNNM4 (FusionGDB2 ID:6492)

Fusion Gene Summary for ARID5A-CNNM4

Fusion gene summary

Fusion gene information	Fusion gene name: ARID5A-CNNM4
	Fusion gene ID: 6492
		Hgene	Tgene
	Gene symbol	ARID5A	CNNM4
	Gene ID	10865	26504
	Gene name	AT-rich interaction domain 5A	cyclin and CBS domain divalent metal cation transport mediator 4
	Synonyms	MRF-1\|MRF1\|RP11-363D14	ACDP4
	Cytomap	2q11.2	2q11.2
	Type of gene	protein-coding	protein-coding
	Description	AT-rich interactive domain-containing protein 5AARID domain-containing protein 5AAT rich interactive domain 5A (MRF1-like)RFVG5814modulator recognition factor 1modulator recognition factor I	metal transporter CNNM4ancient conserved domain protein 4ancient conserved domain-containing protein 4cyclin-M4
	Modification date	20200320	20200313
	UniProtAcc	Q03989	Q6P4Q7
	Ensembl transtripts involved in fusion gene	ENST00000357485, ENST00000454558,	ENST00000496186, ENST00000540067, ENST00000377075,
Fusion gene scores	* DoF score	4 X 3 X 3=36	4 X 5 X 2=40
	# samples	4	5
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ARID5A [Title/Abstract] AND CNNM4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARID5A(97202567)-CNNM4(97462749), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARID5A	GO:0000122	negative regulation of transcription by RNA polymerase II	15941852
Hgene	ARID5A	GO:0071391	cellular response to estrogen stimulus	15941852
Tgene	CNNM4	GO:0055065	metal ion homeostasis	15840172

Fusion gene breakpoints across ARID5A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CNNM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AM-5820-01A	ARID5A	chr2	97202567	+	CNNM4	chr2	97462749	+
ChimerDB4	COAD	TCGA-AM-5820	ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+

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Fusion Gene ORF analysis for ARID5A-CNNM4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000357485	ENST00000496186	ARID5A	chr2	97202567	+	CNNM4	chr2	97462749	+
5CDS-3UTR	ENST00000357485	ENST00000496186	ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+
5CDS-5UTR	ENST00000357485	ENST00000540067	ARID5A	chr2	97202567	+	CNNM4	chr2	97462749	+
5CDS-5UTR	ENST00000357485	ENST00000540067	ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+
In-frame	ENST00000357485	ENST00000377075	ARID5A	chr2	97202567	+	CNNM4	chr2	97462749	+
In-frame	ENST00000357485	ENST00000377075	ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+
intron-3CDS	ENST00000454558	ENST00000377075	ARID5A	chr2	97202567	+	CNNM4	chr2	97462749	+
intron-3CDS	ENST00000454558	ENST00000377075	ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+
intron-3UTR	ENST00000454558	ENST00000496186	ARID5A	chr2	97202567	+	CNNM4	chr2	97462749	+
intron-3UTR	ENST00000454558	ENST00000496186	ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+
intron-5UTR	ENST00000454558	ENST00000540067	ARID5A	chr2	97202567	+	CNNM4	chr2	97462749	+
intron-5UTR	ENST00000454558	ENST00000540067	ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000357485

ARID5A

chr2

97202567

ENST00000377075

CNNM4

chr2

97462749

3382

1007

309

ENST00000357485

ARID5A

chr2

97202567

ENST00000377075

CNNM4

chr2

97462748

3382

1007

309

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000357485	ENST00000377075	ARID5A	chr2	97202567	+	CNNM4	chr2	97462749	+	0.002848439	0.99715155
ENST00000357485	ENST00000377075	ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+	0.002848439	0.99715155

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Fusion Genomic Features for ARID5A-CNNM4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+	2.84E-06	0.99999714
ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+	2.84E-06	0.99999714
ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+	2.84E-06	0.99999714
ARID5A	chr2	97202567	+	CNNM4	chr2	97462748	+	2.84E-06	0.99999714

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARID5A-CNNM4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:97202567/chr2:97462749)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARID5A Q03989	CNNM4 Q6P4Q7
FUNCTION: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). {ECO:0000250\|UniProtKB:Q3U108, ECO:0000269\|PubMed:15941852, ECO:0000269\|PubMed:8649988}.	FUNCTION: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269\|PubMed:19200525, ECO:0000269\|PubMed:19200527}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARID5A

chr2:97202567

chr2:97462748

ENST00000357485

55_147

595.0

Domain

ARID

Hgene

ARID5A

chr2:97202567

chr2:97462749

ENST00000357485

55_147

595.0

Domain

ARID

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

178_358

467

776.0

Domain

CNNM transmembrane

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

377_438

467

776.0

Domain

CBS 1

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

445_511

467

776.0

Domain

CBS 2

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

178_358

467

776.0

Domain

CNNM transmembrane

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

377_438

467

776.0

Domain

CBS 1

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

445_511

467

776.0

Domain

CBS 2

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

241_261

467

776.0

Intramembrane

Helical

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

241_261

467

776.0

Intramembrane

Helical

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

1_178

467

776.0

Topological domain

Extracellular

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

200_240

467

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

262_264

467

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

286_293

467

776.0

Topological domain

Extracellular

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

317_775

467

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

1_178

467

776.0

Topological domain

Extracellular

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

200_240

467

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

262_264

467

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

286_293

467

776.0

Topological domain

Extracellular

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

317_775

467

776.0

Topological domain

Cytoplasmic

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

179_199

467

776.0

Transmembrane

Helical

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

265_285

467

776.0

Transmembrane

Helical

Tgene

CNNM4

chr2:97202567

chr2:97462748

ENST00000377075

294_316

467

776.0

Transmembrane

Helical

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

179_199

467

776.0

Transmembrane

Helical

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

265_285

467

776.0

Transmembrane

Helical

Tgene

CNNM4

chr2:97202567

chr2:97462749

ENST00000377075

294_316

467

776.0

Transmembrane

Helical

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Fusion Gene Sequence for ARID5A-CNNM4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>6492_6492_1_ARID5A-CNNM4_ARID5A_chr2_97202567_ENST00000357485_CNNM4_chr2_97462748_ENST00000377075_length(transcript)=3382nt_BP=82nt
AGTATCTCAGAGAGCGCGGGGTCCGGACAGCCGCGCGCTGAGGGTCTCGGGGCGGGCGCCGCGGGACCTCTCCGGGCCATGGGGAAGTCC
CACCTGGCCATCGTGCAGAAGGTAAACAACGAGGGTGAGGGTGACCCCTTCTACGAGGTCCTGGGCCTGGTCACCCTGGAGGACGTGATC
GAGGAGATCATCAAGTCGGAGATCCTGGACGAGTCCGACATGTACACTGACAACCGAAGCCGGAAGCGGGTGTCTGAGAAGAACAAGCGT
GACTTCTCTGCCTTCAAGGATGCGGACAATGAGCTCAAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCCGCTCATCGCTTCCTAGCCACA
GAGGTCTCTCAGTTTAGCCCCTCCCTGATATCAGAGAAGATCCTGCTGCGGCTACTCAAGTACCCAGATGTCATTCAGGAACTCAAGTTT
GACGAGCACAATAAGTACTACGCCCGCCATTACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATCCTGCAGGGGAAGGTG
GAGGTGGAGGCAGGGAAGGAGAACATGAAGTTTGAGACGGGCGCCTTCTCCTACTATGGGACTATGGCCCTGACCTCGGTCCCCTCCGAC
CGTTCCCCAGCACACCCCACCCCACTCAGCCGCTCAGCCTCCCTCAGTTACCCAGACCGCACAGACGTCTCAACTGCAGCAACCTTGGCA
GGCAGCAGCAACCAGTTTGGCAGCTCTGTCCTGGGCCAGTACATCTCTGACTTCAGCGTCCGGGCACTCGTGGACTTGCAGTACATCAAG
ATCACTCGGCAGCAGTACCAGAACGGGCTGCTGGCTTCTCGCATGGAGAACAGCCCTCAGTTTCCCATAGACGGGTGCACCACCCACATG
GAGAACTTGGCCGAGAAGTCTGAGCTGCCTGTGGTGGACGAGACCACAACTCTTCTCAACGAGCGTAACTCCTTGCTGCACAAAGCCTCC
CACGAGAATGCCATCTGACAGGAGGGCCCGGGGCCCCCTGCCCACCCTGCGGGGGCCTCCCCAGTGGGCCCACATGAAGAGAGGGAACCT
GTTAGTCCAGAAAGGATACGGATAGATAGCCTGTCTGACTGAACAGCCAGATGGCCCCCAGCCTATGGGGGATCTGGCCTCTGCCAGGGA
CCTCTGAGTAGCTCTGAGGTGGCACTGTCCAGCCCTGGATAGGGGGGGCAGTGGGCCAGCTACCGTAAGCAAAGGCTGTTTTTTACTGAG
AGAATTTCTAAAGTAGGCTCATCACTTTTTTTTAAATATCATTTTGGGAAGGGAAGACAGGGTTAAGGAACTTTATTTAAAAAAAAAATA
TTTTTTTCCTAAAAACTATAAAAGAGGAAGGGTTTCTTGTCCCGGGAAGCAACGGACATAATCTGTTCCCAGCCATGGCCTTCCAGCTTG
TGTCCCTGATTCAGGGAGCTCTCCCTTCCTCCTCCTCCTCCTCCTCCGGAGGTGGGATCCCAGAGCCTGCCAGTGGAGGCTTATCTGTTG
GGAGGAAGACAGCTCTTCACAGAAGCAAAGAACAAAATGGCATGGAGATCAGCTGCCTGAGCACCTGCGCTGTAGCTTATCTGACAACGC
TGAGGCCACGAGCTCCTGGGTAGCTGTGATCAGGGACATGATAATCTGAGCTATGCAGAGGAGCACATCTGTTGTCAACTGCTGTACCCA
GAAATCTAGAACTCTGCCGACAGCCTCTCCTGGTGAGTCGGGACTCAGCTGAGGACACATCCCCACCCTGCCTCCCATCTGGCCCTTTGG
ACAACTGGCCCTTTGTGACAGGGCTGACTCAAGTGTTAGGCAGGGTCTCAGGCCTTTGATTGCTCACCCCTGCTCCCCAGGCCCTGCCCT
CACTTTTACCAAAGGTTCTCCCTCGGCGGGAGGGCATCTGTGTTGGAGGTGATTTGTCTGGGTTCTTCCTTTTGGTTCCAGAAGGAACTG
TCAGTCATCAGCATCTGCGTTGTTAGCAGTCAGTACCACCCCCGCCCCACAATGACAGTCAAGGCTGACTTGTTGACTGAAGCCTTTTTC
CCAGACCCCTTATTTCGAATCCCCAAGCTTCAGTCCCTCTTGGGGGTGGAGACAAGAGGACATGTGGGAAGCCACGGAAGCAGGTTCTTT
ATGTCCTCTCCTCTGTGGCTGGCAAGGCTCACCTGGCCTTATCCACCCACTTATGGAACCTCAGGAGAGGAGGGCTCCTCCTAAAGGCAT
GCAGCTTGCAGCCCCTCTTTCTCACACGTGTGATCCTAGCGTGAGAGGTCATCCTGCCCTTGCTGAAGTTAGTAGTACTGTACTAAGAGC
TCTGCCCTCATGTGAATTCCTGCCCTGGCGCCTCTTCCCTGGGGCTGAATCAGGCCCTGCTGCAAAACTCCAGGCTTCCCAGGGTTGGGG
AGGCTGTGGGACCAAGGTCCATGTTGGTCCTTCCACTGGGTGCAGCAGGAGCTGGGTCCCGAGAGCCTGGCAGGTGAAACTCTGCAGGCC
TTCCGCCTGATTATTATTTATTCACTCCTTTCCTCACCCCAAGTGCCCTGCTCTCCAGGTGCCTAGAGTATCCTAACTCTTAGGACCAGG
GATTGTCTTGCACCAAGTATGCCTACCCCTGGCCAGTCTGAGGTCTCCTAGCCATAGAACTGACTCCTGGAAGCCTGGAGAGAAGGTGGT
GACACCCATGGGTTCTCAACTGTAAGGAAAAAAGACACCAGACTTTTGTTCCCTAGTGGGGGAAAGCCCTTAGTCTTGTACAGGAGCAGC
TTGCTCCCAAGTCCTTTTGGAAGCTGGCAGAGCTATATTCCTGACAGCCCTGACTGCCAGGTAGAGCAAAAGACATTGGTGGGGGTATGT
GAAGCAAAAGGGGCAGGTGCACACACCTCCACAGTGACCTCTGTGCACACGGTTACCACCAACTGGCTGGCCCTCCTCCTCTTCCCTGGC
CCATTGATCATCCCTTCTCACAGAGGGTCATCATTATTTCCAAATATTGTTTGTCTGATGACTTCCTCTTCCCAGTGCAATTTTTCCCTT
CCTATTTCAACCTCTGGTTCCTGGGATGAGCCATACCCTGGAACTGGCCCACCCACTGTGTCTTCCACGTAAGGGAGACCTTTGCAAAGG
GCATCCAAATGGGTAGGCAGGTGACAGCCGCCGTATTTATTTTGCATAATATTTTAATTTGTATATTTTTGTGATTTATTTTGGCGTTAT
GAGTTTGACTCTCGGGGAGTTTTGTTGTTATGACTCTTGTGTCTTTTGTCACAAAACAATGATATTTGCTAAACGATATATGGAATTTAT

>6492_6492_1_ARID5A-CNNM4_ARID5A_chr2_97202567_ENST00000357485_CNNM4_chr2_97462748_ENST00000377075_length(amino acids)=309AA_BP=1
MGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHR
FLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTS
VPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGC

--------------------------------------------------------------
>6492_6492_2_ARID5A-CNNM4_ARID5A_chr2_97202567_ENST00000357485_CNNM4_chr2_97462749_ENST00000377075_length(transcript)=3382nt_BP=82nt
AGTATCTCAGAGAGCGCGGGGTCCGGACAGCCGCGCGCTGAGGGTCTCGGGGCGGGCGCCGCGGGACCTCTCCGGGCCATGGGGAAGTCC
CACCTGGCCATCGTGCAGAAGGTAAACAACGAGGGTGAGGGTGACCCCTTCTACGAGGTCCTGGGCCTGGTCACCCTGGAGGACGTGATC
GAGGAGATCATCAAGTCGGAGATCCTGGACGAGTCCGACATGTACACTGACAACCGAAGCCGGAAGCGGGTGTCTGAGAAGAACAAGCGT
GACTTCTCTGCCTTCAAGGATGCGGACAATGAGCTCAAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCCGCTCATCGCTTCCTAGCCACA
GAGGTCTCTCAGTTTAGCCCCTCCCTGATATCAGAGAAGATCCTGCTGCGGCTACTCAAGTACCCAGATGTCATTCAGGAACTCAAGTTT
GACGAGCACAATAAGTACTACGCCCGCCATTACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATCCTGCAGGGGAAGGTG
GAGGTGGAGGCAGGGAAGGAGAACATGAAGTTTGAGACGGGCGCCTTCTCCTACTATGGGACTATGGCCCTGACCTCGGTCCCCTCCGAC
CGTTCCCCAGCACACCCCACCCCACTCAGCCGCTCAGCCTCCCTCAGTTACCCAGACCGCACAGACGTCTCAACTGCAGCAACCTTGGCA
GGCAGCAGCAACCAGTTTGGCAGCTCTGTCCTGGGCCAGTACATCTCTGACTTCAGCGTCCGGGCACTCGTGGACTTGCAGTACATCAAG
ATCACTCGGCAGCAGTACCAGAACGGGCTGCTGGCTTCTCGCATGGAGAACAGCCCTCAGTTTCCCATAGACGGGTGCACCACCCACATG
GAGAACTTGGCCGAGAAGTCTGAGCTGCCTGTGGTGGACGAGACCACAACTCTTCTCAACGAGCGTAACTCCTTGCTGCACAAAGCCTCC
CACGAGAATGCCATCTGACAGGAGGGCCCGGGGCCCCCTGCCCACCCTGCGGGGGCCTCCCCAGTGGGCCCACATGAAGAGAGGGAACCT
GTTAGTCCAGAAAGGATACGGATAGATAGCCTGTCTGACTGAACAGCCAGATGGCCCCCAGCCTATGGGGGATCTGGCCTCTGCCAGGGA
CCTCTGAGTAGCTCTGAGGTGGCACTGTCCAGCCCTGGATAGGGGGGGCAGTGGGCCAGCTACCGTAAGCAAAGGCTGTTTTTTACTGAG
AGAATTTCTAAAGTAGGCTCATCACTTTTTTTTAAATATCATTTTGGGAAGGGAAGACAGGGTTAAGGAACTTTATTTAAAAAAAAAATA
TTTTTTTCCTAAAAACTATAAAAGAGGAAGGGTTTCTTGTCCCGGGAAGCAACGGACATAATCTGTTCCCAGCCATGGCCTTCCAGCTTG
TGTCCCTGATTCAGGGAGCTCTCCCTTCCTCCTCCTCCTCCTCCTCCGGAGGTGGGATCCCAGAGCCTGCCAGTGGAGGCTTATCTGTTG
GGAGGAAGACAGCTCTTCACAGAAGCAAAGAACAAAATGGCATGGAGATCAGCTGCCTGAGCACCTGCGCTGTAGCTTATCTGACAACGC
TGAGGCCACGAGCTCCTGGGTAGCTGTGATCAGGGACATGATAATCTGAGCTATGCAGAGGAGCACATCTGTTGTCAACTGCTGTACCCA
GAAATCTAGAACTCTGCCGACAGCCTCTCCTGGTGAGTCGGGACTCAGCTGAGGACACATCCCCACCCTGCCTCCCATCTGGCCCTTTGG
ACAACTGGCCCTTTGTGACAGGGCTGACTCAAGTGTTAGGCAGGGTCTCAGGCCTTTGATTGCTCACCCCTGCTCCCCAGGCCCTGCCCT
CACTTTTACCAAAGGTTCTCCCTCGGCGGGAGGGCATCTGTGTTGGAGGTGATTTGTCTGGGTTCTTCCTTTTGGTTCCAGAAGGAACTG
TCAGTCATCAGCATCTGCGTTGTTAGCAGTCAGTACCACCCCCGCCCCACAATGACAGTCAAGGCTGACTTGTTGACTGAAGCCTTTTTC
CCAGACCCCTTATTTCGAATCCCCAAGCTTCAGTCCCTCTTGGGGGTGGAGACAAGAGGACATGTGGGAAGCCACGGAAGCAGGTTCTTT
ATGTCCTCTCCTCTGTGGCTGGCAAGGCTCACCTGGCCTTATCCACCCACTTATGGAACCTCAGGAGAGGAGGGCTCCTCCTAAAGGCAT
GCAGCTTGCAGCCCCTCTTTCTCACACGTGTGATCCTAGCGTGAGAGGTCATCCTGCCCTTGCTGAAGTTAGTAGTACTGTACTAAGAGC
TCTGCCCTCATGTGAATTCCTGCCCTGGCGCCTCTTCCCTGGGGCTGAATCAGGCCCTGCTGCAAAACTCCAGGCTTCCCAGGGTTGGGG
AGGCTGTGGGACCAAGGTCCATGTTGGTCCTTCCACTGGGTGCAGCAGGAGCTGGGTCCCGAGAGCCTGGCAGGTGAAACTCTGCAGGCC
TTCCGCCTGATTATTATTTATTCACTCCTTTCCTCACCCCAAGTGCCCTGCTCTCCAGGTGCCTAGAGTATCCTAACTCTTAGGACCAGG
GATTGTCTTGCACCAAGTATGCCTACCCCTGGCCAGTCTGAGGTCTCCTAGCCATAGAACTGACTCCTGGAAGCCTGGAGAGAAGGTGGT
GACACCCATGGGTTCTCAACTGTAAGGAAAAAAGACACCAGACTTTTGTTCCCTAGTGGGGGAAAGCCCTTAGTCTTGTACAGGAGCAGC
TTGCTCCCAAGTCCTTTTGGAAGCTGGCAGAGCTATATTCCTGACAGCCCTGACTGCCAGGTAGAGCAAAAGACATTGGTGGGGGTATGT
GAAGCAAAAGGGGCAGGTGCACACACCTCCACAGTGACCTCTGTGCACACGGTTACCACCAACTGGCTGGCCCTCCTCCTCTTCCCTGGC
CCATTGATCATCCCTTCTCACAGAGGGTCATCATTATTTCCAAATATTGTTTGTCTGATGACTTCCTCTTCCCAGTGCAATTTTTCCCTT
CCTATTTCAACCTCTGGTTCCTGGGATGAGCCATACCCTGGAACTGGCCCACCCACTGTGTCTTCCACGTAAGGGAGACCTTTGCAAAGG
GCATCCAAATGGGTAGGCAGGTGACAGCCGCCGTATTTATTTTGCATAATATTTTAATTTGTATATTTTTGTGATTTATTTTGGCGTTAT
GAGTTTGACTCTCGGGGAGTTTTGTTGTTATGACTCTTGTGTCTTTTGTCACAAAACAATGATATTTGCTAAACGATATATGGAATTTAT

>6492_6492_2_ARID5A-CNNM4_ARID5A_chr2_97202567_ENST00000357485_CNNM4_chr2_97462749_ENST00000377075_length(amino acids)=309AA_BP=1
MGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHR
FLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTS
VPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGC

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Fusion Gene PPI Analysis for ARID5A-CNNM4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ARID5A	chr2:97202567	chr2:97462748	ENST00000357485	+	1	7	1_300	1.3333333333333333	595.0	SOX9
Hgene	ARID5A	chr2:97202567	chr2:97462749	ENST00000357485	+	1	7	1_300	1.3333333333333333	595.0	SOX9

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARID5A-CNNM4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARID5A-CNNM4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source