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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PHKB-VRK2 (FusionGDB2 ID:64944)

Fusion Gene Summary for PHKB-VRK2

Fusion gene summary

Fusion gene information	Fusion gene name: PHKB-VRK2
	Fusion gene ID: 64944
		Hgene	Tgene
	Gene symbol	PHKB	VRK2
	Gene ID	5257	7444
	Gene name	phosphorylase kinase regulatory subunit beta	VRK serine/threonine kinase 2
	Synonyms	-	-
	Cytomap	16q12.1	2p16.1
	Type of gene	protein-coding	protein-coding
	Description	phosphorylase b kinase regulatory subunit betaphosphorylase kinase beta-subunitphosphorylase kinase subunit betaphosphorylase kinase, beta	serine/threonine-protein kinase VRK2vaccinia related kinase 2vaccinia virus B1R-related kinase 2
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000567402, ENST00000299167, ENST00000323584, ENST00000455779, ENST00000566044,	ENST00000417641, ENST00000435505, ENST00000340157, ENST00000412104, ENST00000440705, ENST00000478687,
Fusion gene scores	* DoF score	11 X 11 X 8=968	4 X 3 X 3=36
	# samples	11	4
	** MAII score	log2(11/968*10)=-3.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PHKB [Title/Abstract] AND VRK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PHKB(47531399)-VRK2(58313473), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	VRK2	GO:0046777	protein autophosphorylation	14645249\|16704422

Fusion gene breakpoints across PHKB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-IG-A51D	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+

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Fusion Gene ORF analysis for PHKB-VRK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000567402	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
3UTR-3CDS	ENST00000567402	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
3UTR-intron	ENST00000567402	ENST00000340157	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
3UTR-intron	ENST00000567402	ENST00000412104	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
3UTR-intron	ENST00000567402	ENST00000440705	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
3UTR-intron	ENST00000567402	ENST00000478687	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000299167	ENST00000340157	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000299167	ENST00000412104	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000299167	ENST00000440705	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000299167	ENST00000478687	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000323584	ENST00000340157	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000323584	ENST00000412104	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000323584	ENST00000440705	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000323584	ENST00000478687	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000455779	ENST00000340157	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000455779	ENST00000412104	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000455779	ENST00000440705	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000455779	ENST00000478687	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000566044	ENST00000340157	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000566044	ENST00000412104	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000566044	ENST00000440705	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
5CDS-intron	ENST00000566044	ENST00000478687	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
In-frame	ENST00000299167	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
In-frame	ENST00000299167	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
In-frame	ENST00000323584	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
In-frame	ENST00000323584	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
In-frame	ENST00000455779	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
In-frame	ENST00000455779	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
In-frame	ENST00000566044	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+
In-frame	ENST00000566044	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000566044	PHKB	chr16	47531399	+	ENST00000435505	VRK2	chr2	58313473	+	1779	334	189	1604	471
ENST00000566044	PHKB	chr16	47531399	+	ENST00000417641	VRK2	chr2	58313473	+	1832	334	189	1268	359
ENST00000455779	PHKB	chr16	47531399	+	ENST00000435505	VRK2	chr2	58313473	+	1775	330	185	1600	471
ENST00000455779	PHKB	chr16	47531399	+	ENST00000417641	VRK2	chr2	58313473	+	1828	330	185	1264	359
ENST00000299167	PHKB	chr16	47531399	+	ENST00000435505	VRK2	chr2	58313473	+	1636	191	25	1461	478
ENST00000299167	PHKB	chr16	47531399	+	ENST00000417641	VRK2	chr2	58313473	+	1689	191	25	1125	366
ENST00000323584	PHKB	chr16	47531399	+	ENST00000435505	VRK2	chr2	58313473	+	1635	190	24	1460	478
ENST00000323584	PHKB	chr16	47531399	+	ENST00000417641	VRK2	chr2	58313473	+	1688	190	24	1124	366

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000566044	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	0.000246341	0.99975365
ENST00000566044	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	0.000296211	0.9997037
ENST00000455779	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	0.000246306	0.99975365
ENST00000455779	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	0.000291917	0.9997081
ENST00000299167	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	0.000326847	0.9996731
ENST00000299167	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	0.000363251	0.99963677
ENST00000323584	ENST00000435505	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	0.00032527	0.9996748
ENST00000323584	ENST00000417641	PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	0.000361352	0.9996387

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Fusion Genomic Features for PHKB-VRK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	3.09E-05	0.999969
PHKB	chr16	47531399	+	VRK2	chr2	58313473	+	3.09E-05	0.999969

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHKB-VRK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:47531399/chr2:58313473)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000299167

7_29

1094.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000323584

7_29

1094.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000455779

7_29

1087.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000566044

7_29

1087.0

Region

Calmodulin-binding

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000340157

487_507

509.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000412104

487_507

511.6666666666667

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000417641

487_507

508.3333333333333

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000435505

487_507

509.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000440705

487_507

486.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000299167

768_795

1094.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000299167

920_951

1094.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000323584

768_795

1094.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000323584

920_951

1094.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000455779

768_795

1087.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000455779

920_951

1087.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000566044

768_795

1087.0

Region

Calmodulin-binding

Hgene

PHKB

chr16:47531399

chr2:58313473

ENST00000566044

920_951

1087.0

Region

Calmodulin-binding

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000340157

29_319

509.0

Domain

Protein kinase

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000412104

29_319

511.6666666666667

Domain

Protein kinase

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000417641

29_319

508.3333333333333

Domain

Protein kinase

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000435505

29_319

509.0

Domain

Protein kinase

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000440705

29_319

486.0

Domain

Protein kinase

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000340157

35_43

509.0

Nucleotide binding

ATP

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000412104

35_43

511.6666666666667

Nucleotide binding

ATP

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000417641

35_43

508.3333333333333

Nucleotide binding

ATP

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000435505

35_43

509.0

Nucleotide binding

ATP

Tgene

VRK2

chr16:47531399

chr2:58313473

ENST00000440705

35_43

486.0

Nucleotide binding

ATP

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Fusion Gene Sequence for PHKB-VRK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64944_64944_1_PHKB-VRK2_PHKB_chr16_47531399_ENST00000299167_VRK2_chr2_58313473_ENST00000417641_length(transcript)=1689nt_BP=191nt
TGGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTGGAAGGTCTTGGAGCGAAGAGCTCGGAC
CAAGCGCTCAGGCTCAGTTTATGAACCTCTTAAAAGCATTAATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTA
TTACAGAATTGTCAAAAAGTGGATAGAACGCAAACAACTTGATTATTTAGGAATTCCTCTGTTTTATGGATCTGGTCTGACTGAATTCAA
GGGAAGAAGTTACAGATTTATGGTAATGGAAAGACTAGGAATAGATTTACAGAAGATCTCAGGCCAGAATGGTACCTTTAAAAAGTCAAC
TGTCCTGCAATTAGGTATCCGAATGTTGGATGTACTGGAATATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCT
ACTTTTGGGTTACAAAAATCCAGACCAGGTTTATCTTGCAGATTATGGACTTTCCTACAGATATTGTCCCAATGGGAACCACAAACAGTA
TCAGGAAAATCCTAGAAAAGGCCATAATGGGACAATAGAGTTTACCAGCTTGGATGCCCACAAGGGAGTAGCCTTGTCCAGACGAAGTGA
CGTTGAGATCCTCGGCTACTGCATGCTGCGGTGGTTGTGTGGGAAACTTCCCTGGGAACAGAACCTGAAGGACCCTGTGGCTGTGCAGAC
TGCTAAAACAAATCTGTTGGACGAGCTCCCCCAGTCAGTGCTTAAATGGGCTCCTTCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTT
GGTATGTGCTCATAGTTTAGCATATGATGAAAAGCCAAACTATCAAGCCCTCAAGAAAATTTTGAACCCTCATGGAATACCTTTAGGACC
ACTGGACTTTTCCACAAAAGGACAGAGTATAAATGTCCATACTCCAAACAGTCAAAAAGTTGATTCACAAAAGGCTGCAACAAAGCAAGT
CAACAAGGCACACAATAGGTTAATCGAAAAAAAAGTCCACAGTGAGAGAAGCGCTGAGTCCTGTGCAACATGGAAAGTGCAGAAAGAGGA
GAAACTGATTGGATTGATGAACAATGAAGCAGCTCAGTTTAGGTAGAAGCTTAGGCTATTGATTTGAACCCACTATTTTTTCTAATGAAA
GCACAAGGAGAAGACAGAAATATCAAGAGTCTCAAGAACCTTTGAATGAAGTAAACAGTTTCCCACAAAAAATCAGCTATACACAATTCC
CAAACTCATTTTATGAGCCTCATCAAGATTTTACCAGTCCAGATATATTCAAGAAGTCAAGATCTCCATCTTGGTATAAATACACTTCCA
CAGTCAGCACGGGGATCACAGACTTAGAAAGTTCAACTGGACTTTGGCCTACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAACGCAG
ATGTTTATTATTATCGCATCATCATACCTGTCCTTTTGATGTTAGTATTTCTTGCTTTATTTTTTCTCTGAAGATGATACCAAAATTCCT
TTTGATAATTTTTTAAGTTTCCAGCTCTTCACCGAAATGTTGTATTCTTATTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAATTGGCT

>64944_64944_1_PHKB-VRK2_PHKB_chr16_47531399_ENST00000299167_VRK2_chr2_58313473_ENST00000417641_length(amino acids)=366AA_BP=55
MAGAAGLTAEVSWKVLERRARTKRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGH
NGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNN

--------------------------------------------------------------
>64944_64944_2_PHKB-VRK2_PHKB_chr16_47531399_ENST00000299167_VRK2_chr2_58313473_ENST00000435505_length(transcript)=1636nt_BP=191nt
TGGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTGGAAGGTCTTGGAGCGAAGAGCTCGGAC
CAAGCGCTCAGGCTCAGTTTATGAACCTCTTAAAAGCATTAATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTA
TTACAGAATTGTCAAAAAGTGGATAGAACGCAAACAACTTGATTATTTAGGAATTCCTCTGTTTTATGGATCTGGTCTGACTGAATTCAA
GGGAAGAAGTTACAGATTTATGGTAATGGAAAGACTAGGAATAGATTTACAGAAGATCTCAGGCCAGAATGGTACCTTTAAAAAGTCAAC
TGTCCTGCAATTAGGTATCCGAATGTTGGATGTACTGGAATATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCT
ACTTTTGGGTTACAAAAATCCAGACCAGGTTTATCTTGCAGATTATGGACTTTCCTACAGATATTGTCCCAATGGGAACCACAAACAGTA
TCAGGAAAATCCTAGAAAAGGCCATAATGGGACAATAGAGTTTACCAGCTTGGATGCCCACAAGGGAGTAGCCTTGTCCAGACGAAGTGA
CGTTGAGATCCTCGGCTACTGCATGCTGCGGTGGTTGTGTGGGAAACTTCCCTGGGAACAGAACCTGAAGGACCCTGTGGCTGTGCAGAC
TGCTAAAACAAATCTGTTGGACGAGCTCCCCCAGTCAGTGCTTAAATGGGCTCCTTCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTT
GGTATGTGCTCATAGTTTAGCATATGATGAAAAGCCAAACTATCAAGCCCTCAAGAAAATTTTGAACCCTCATGGAATACCTTTAGGACC
ACTGGACTTTTCCACAAAAGGACAGAGTATAAATGTCCATACTCCAAACAGTCAAAAAGTTGATTCACAAAAGGCTGCAACAAAGCAAGT
CAACAAGGCACACAATAGGTTAATCGAAAAAAAAGTCCACAGTGAGAGAAGCGCTGAGTCCTGTGCAACATGGAAAGTGCAGAAAGAGGA
GAAACTGATTGGATTGATGAACAATGAAGCAGCTCAGGAAAGCACAAGGAGAAGACAGAAATATCAAGAGTCTCAAGAACCTTTGAATGA
AGTAAACAGTTTCCCACAAAAAATCAGCTATACACAATTCCCAAACTCATTTTATGAGCCTCATCAAGATTTTACCAGTCCAGATATATT
CAAGAAGTCAAGATCTCCATCTTGGTATAAATACACTTCCACAGTCAGCACGGGGATCACAGACTTAGAAAGTTCAACTGGACTTTGGCC
TACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAACGCAGATGTTTATTATTATCGCATCATCATACCTGTCCTTTTGATGTTAGTATT
TCTTGCTTTATTTTTTCTCTGAAGATGATACCAAAATTCCTTTTGATAATTTTTTAAGTTTCCAGCTCTTCACCGAAATGTTGTATTCTT
ATTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAATTGGCTTTAAAAAGAGAACATATTTTAACAAAGTTTGTGGACACTCTAAAAAATA

>64944_64944_2_PHKB-VRK2_PHKB_chr16_47531399_ENST00000299167_VRK2_chr2_58313473_ENST00000435505_length(amino acids)=478AA_BP=55
MAGAAGLTAEVSWKVLERRARTKRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGH
NGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNN
EAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS

--------------------------------------------------------------
>64944_64944_3_PHKB-VRK2_PHKB_chr16_47531399_ENST00000323584_VRK2_chr2_58313473_ENST00000417641_length(transcript)=1688nt_BP=190nt
GGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTGGAAGGTCTTGGAGCGAAGAGCTCGGACC
AAGCGCTCAGGCTCAGTTTATGAACCTCTTAAAAGCATTAATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTAT
TACAGAATTGTCAAAAAGTGGATAGAACGCAAACAACTTGATTATTTAGGAATTCCTCTGTTTTATGGATCTGGTCTGACTGAATTCAAG
GGAAGAAGTTACAGATTTATGGTAATGGAAAGACTAGGAATAGATTTACAGAAGATCTCAGGCCAGAATGGTACCTTTAAAAAGTCAACT
GTCCTGCAATTAGGTATCCGAATGTTGGATGTACTGGAATATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCTA
CTTTTGGGTTACAAAAATCCAGACCAGGTTTATCTTGCAGATTATGGACTTTCCTACAGATATTGTCCCAATGGGAACCACAAACAGTAT
CAGGAAAATCCTAGAAAAGGCCATAATGGGACAATAGAGTTTACCAGCTTGGATGCCCACAAGGGAGTAGCCTTGTCCAGACGAAGTGAC
GTTGAGATCCTCGGCTACTGCATGCTGCGGTGGTTGTGTGGGAAACTTCCCTGGGAACAGAACCTGAAGGACCCTGTGGCTGTGCAGACT
GCTAAAACAAATCTGTTGGACGAGCTCCCCCAGTCAGTGCTTAAATGGGCTCCTTCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTTG
GTATGTGCTCATAGTTTAGCATATGATGAAAAGCCAAACTATCAAGCCCTCAAGAAAATTTTGAACCCTCATGGAATACCTTTAGGACCA
CTGGACTTTTCCACAAAAGGACAGAGTATAAATGTCCATACTCCAAACAGTCAAAAAGTTGATTCACAAAAGGCTGCAACAAAGCAAGTC
AACAAGGCACACAATAGGTTAATCGAAAAAAAAGTCCACAGTGAGAGAAGCGCTGAGTCCTGTGCAACATGGAAAGTGCAGAAAGAGGAG
AAACTGATTGGATTGATGAACAATGAAGCAGCTCAGTTTAGGTAGAAGCTTAGGCTATTGATTTGAACCCACTATTTTTTCTAATGAAAG
CACAAGGAGAAGACAGAAATATCAAGAGTCTCAAGAACCTTTGAATGAAGTAAACAGTTTCCCACAAAAAATCAGCTATACACAATTCCC
AAACTCATTTTATGAGCCTCATCAAGATTTTACCAGTCCAGATATATTCAAGAAGTCAAGATCTCCATCTTGGTATAAATACACTTCCAC
AGTCAGCACGGGGATCACAGACTTAGAAAGTTCAACTGGACTTTGGCCTACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAACGCAGA
TGTTTATTATTATCGCATCATCATACCTGTCCTTTTGATGTTAGTATTTCTTGCTTTATTTTTTCTCTGAAGATGATACCAAAATTCCTT
TTGATAATTTTTTAAGTTTCCAGCTCTTCACCGAAATGTTGTATTCTTATTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAATTGGCTT

>64944_64944_3_PHKB-VRK2_PHKB_chr16_47531399_ENST00000323584_VRK2_chr2_58313473_ENST00000417641_length(amino acids)=366AA_BP=55
MAGAAGLTAEVSWKVLERRARTKRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGH
NGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNN

--------------------------------------------------------------
>64944_64944_4_PHKB-VRK2_PHKB_chr16_47531399_ENST00000323584_VRK2_chr2_58313473_ENST00000435505_length(transcript)=1635nt_BP=190nt
GGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTGGAAGGTCTTGGAGCGAAGAGCTCGGACC
AAGCGCTCAGGCTCAGTTTATGAACCTCTTAAAAGCATTAATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTAT
TACAGAATTGTCAAAAAGTGGATAGAACGCAAACAACTTGATTATTTAGGAATTCCTCTGTTTTATGGATCTGGTCTGACTGAATTCAAG
GGAAGAAGTTACAGATTTATGGTAATGGAAAGACTAGGAATAGATTTACAGAAGATCTCAGGCCAGAATGGTACCTTTAAAAAGTCAACT
GTCCTGCAATTAGGTATCCGAATGTTGGATGTACTGGAATATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCTA
CTTTTGGGTTACAAAAATCCAGACCAGGTTTATCTTGCAGATTATGGACTTTCCTACAGATATTGTCCCAATGGGAACCACAAACAGTAT
CAGGAAAATCCTAGAAAAGGCCATAATGGGACAATAGAGTTTACCAGCTTGGATGCCCACAAGGGAGTAGCCTTGTCCAGACGAAGTGAC
GTTGAGATCCTCGGCTACTGCATGCTGCGGTGGTTGTGTGGGAAACTTCCCTGGGAACAGAACCTGAAGGACCCTGTGGCTGTGCAGACT
GCTAAAACAAATCTGTTGGACGAGCTCCCCCAGTCAGTGCTTAAATGGGCTCCTTCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTTG
GTATGTGCTCATAGTTTAGCATATGATGAAAAGCCAAACTATCAAGCCCTCAAGAAAATTTTGAACCCTCATGGAATACCTTTAGGACCA
CTGGACTTTTCCACAAAAGGACAGAGTATAAATGTCCATACTCCAAACAGTCAAAAAGTTGATTCACAAAAGGCTGCAACAAAGCAAGTC
AACAAGGCACACAATAGGTTAATCGAAAAAAAAGTCCACAGTGAGAGAAGCGCTGAGTCCTGTGCAACATGGAAAGTGCAGAAAGAGGAG
AAACTGATTGGATTGATGAACAATGAAGCAGCTCAGGAAAGCACAAGGAGAAGACAGAAATATCAAGAGTCTCAAGAACCTTTGAATGAA
GTAAACAGTTTCCCACAAAAAATCAGCTATACACAATTCCCAAACTCATTTTATGAGCCTCATCAAGATTTTACCAGTCCAGATATATTC
AAGAAGTCAAGATCTCCATCTTGGTATAAATACACTTCCACAGTCAGCACGGGGATCACAGACTTAGAAAGTTCAACTGGACTTTGGCCT
ACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAACGCAGATGTTTATTATTATCGCATCATCATACCTGTCCTTTTGATGTTAGTATTT
CTTGCTTTATTTTTTCTCTGAAGATGATACCAAAATTCCTTTTGATAATTTTTTAAGTTTCCAGCTCTTCACCGAAATGTTGTATTCTTA
TTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAATTGGCTTTAAAAAGAGAACATATTTTAACAAAGTTTGTGGACACTCTAAAAAATAA

>64944_64944_4_PHKB-VRK2_PHKB_chr16_47531399_ENST00000323584_VRK2_chr2_58313473_ENST00000435505_length(amino acids)=478AA_BP=55
MAGAAGLTAEVSWKVLERRARTKRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGH
NGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNN
EAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS

--------------------------------------------------------------
>64944_64944_5_PHKB-VRK2_PHKB_chr16_47531399_ENST00000455779_VRK2_chr2_58313473_ENST00000417641_length(transcript)=1828nt_BP=330nt
ATTGCTGACAGGCGGCCCCGGGGGCGGTGGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTG
GAAGGTCTTGGAGCGAAGAGCTCGGACCAAGCGCTCAGTTTTAAAATTGCTATAGCTTAGCCTGCGACGCTTATGATTAGAGCCAACAAT
TTGAAATGGCCTGCTCACCTGATGCAGTCGTCTCTCCGTCTTCCGCTTTCTTAAGGTCTGGCTCAGTTTATGAACCTCTTAAAAGCATTA
ATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTATTACAGAATTGTCAAAAAGTGGATAGAACGCAAACAACTTG
ATTATTTAGGAATTCCTCTGTTTTATGGATCTGGTCTGACTGAATTCAAGGGAAGAAGTTACAGATTTATGGTAATGGAAAGACTAGGAA
TAGATTTACAGAAGATCTCAGGCCAGAATGGTACCTTTAAAAAGTCAACTGTCCTGCAATTAGGTATCCGAATGTTGGATGTACTGGAAT
ATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCTACTTTTGGGTTACAAAAATCCAGACCAGGTTTATCTTGCAG
ATTATGGACTTTCCTACAGATATTGTCCCAATGGGAACCACAAACAGTATCAGGAAAATCCTAGAAAAGGCCATAATGGGACAATAGAGT
TTACCAGCTTGGATGCCCACAAGGGAGTAGCCTTGTCCAGACGAAGTGACGTTGAGATCCTCGGCTACTGCATGCTGCGGTGGTTGTGTG
GGAAACTTCCCTGGGAACAGAACCTGAAGGACCCTGTGGCTGTGCAGACTGCTAAAACAAATCTGTTGGACGAGCTCCCCCAGTCAGTGC
TTAAATGGGCTCCTTCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTTGGTATGTGCTCATAGTTTAGCATATGATGAAAAGCCAAACT
ATCAAGCCCTCAAGAAAATTTTGAACCCTCATGGAATACCTTTAGGACCACTGGACTTTTCCACAAAAGGACAGAGTATAAATGTCCATA
CTCCAAACAGTCAAAAAGTTGATTCACAAAAGGCTGCAACAAAGCAAGTCAACAAGGCACACAATAGGTTAATCGAAAAAAAAGTCCACA
GTGAGAGAAGCGCTGAGTCCTGTGCAACATGGAAAGTGCAGAAAGAGGAGAAACTGATTGGATTGATGAACAATGAAGCAGCTCAGTTTA
GGTAGAAGCTTAGGCTATTGATTTGAACCCACTATTTTTTCTAATGAAAGCACAAGGAGAAGACAGAAATATCAAGAGTCTCAAGAACCT
TTGAATGAAGTAAACAGTTTCCCACAAAAAATCAGCTATACACAATTCCCAAACTCATTTTATGAGCCTCATCAAGATTTTACCAGTCCA
GATATATTCAAGAAGTCAAGATCTCCATCTTGGTATAAATACACTTCCACAGTCAGCACGGGGATCACAGACTTAGAAAGTTCAACTGGA
CTTTGGCCTACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAACGCAGATGTTTATTATTATCGCATCATCATACCTGTCCTTTTGATG
TTAGTATTTCTTGCTTTATTTTTTCTCTGAAGATGATACCAAAATTCCTTTTGATAATTTTTTAAGTTTCCAGCTCTTCACCGAAATGTT
GTATTCTTATTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAATTGGCTTTAAAAAGAGAACATATTTTAACAAAGTTTGTGGACACTCT

>64944_64944_5_PHKB-VRK2_PHKB_chr16_47531399_ENST00000455779_VRK2_chr2_58313473_ENST00000417641_length(amino acids)=359AA_BP=48
MACSPDAVVSPSSAFLRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGID
LQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFT
SLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ

--------------------------------------------------------------
>64944_64944_6_PHKB-VRK2_PHKB_chr16_47531399_ENST00000455779_VRK2_chr2_58313473_ENST00000435505_length(transcript)=1775nt_BP=330nt
ATTGCTGACAGGCGGCCCCGGGGGCGGTGGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTG
GAAGGTCTTGGAGCGAAGAGCTCGGACCAAGCGCTCAGTTTTAAAATTGCTATAGCTTAGCCTGCGACGCTTATGATTAGAGCCAACAAT
TTGAAATGGCCTGCTCACCTGATGCAGTCGTCTCTCCGTCTTCCGCTTTCTTAAGGTCTGGCTCAGTTTATGAACCTCTTAAAAGCATTA
ATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTATTACAGAATTGTCAAAAAGTGGATAGAACGCAAACAACTTG
ATTATTTAGGAATTCCTCTGTTTTATGGATCTGGTCTGACTGAATTCAAGGGAAGAAGTTACAGATTTATGGTAATGGAAAGACTAGGAA
TAGATTTACAGAAGATCTCAGGCCAGAATGGTACCTTTAAAAAGTCAACTGTCCTGCAATTAGGTATCCGAATGTTGGATGTACTGGAAT
ATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCTACTTTTGGGTTACAAAAATCCAGACCAGGTTTATCTTGCAG
ATTATGGACTTTCCTACAGATATTGTCCCAATGGGAACCACAAACAGTATCAGGAAAATCCTAGAAAAGGCCATAATGGGACAATAGAGT
TTACCAGCTTGGATGCCCACAAGGGAGTAGCCTTGTCCAGACGAAGTGACGTTGAGATCCTCGGCTACTGCATGCTGCGGTGGTTGTGTG
GGAAACTTCCCTGGGAACAGAACCTGAAGGACCCTGTGGCTGTGCAGACTGCTAAAACAAATCTGTTGGACGAGCTCCCCCAGTCAGTGC
TTAAATGGGCTCCTTCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTTGGTATGTGCTCATAGTTTAGCATATGATGAAAAGCCAAACT
ATCAAGCCCTCAAGAAAATTTTGAACCCTCATGGAATACCTTTAGGACCACTGGACTTTTCCACAAAAGGACAGAGTATAAATGTCCATA
CTCCAAACAGTCAAAAAGTTGATTCACAAAAGGCTGCAACAAAGCAAGTCAACAAGGCACACAATAGGTTAATCGAAAAAAAAGTCCACA
GTGAGAGAAGCGCTGAGTCCTGTGCAACATGGAAAGTGCAGAAAGAGGAGAAACTGATTGGATTGATGAACAATGAAGCAGCTCAGGAAA
GCACAAGGAGAAGACAGAAATATCAAGAGTCTCAAGAACCTTTGAATGAAGTAAACAGTTTCCCACAAAAAATCAGCTATACACAATTCC
CAAACTCATTTTATGAGCCTCATCAAGATTTTACCAGTCCAGATATATTCAAGAAGTCAAGATCTCCATCTTGGTATAAATACACTTCCA
CAGTCAGCACGGGGATCACAGACTTAGAAAGTTCAACTGGACTTTGGCCTACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAACGCAG
ATGTTTATTATTATCGCATCATCATACCTGTCCTTTTGATGTTAGTATTTCTTGCTTTATTTTTTCTCTGAAGATGATACCAAAATTCCT
TTTGATAATTTTTTAAGTTTCCAGCTCTTCACCGAAATGTTGTATTCTTATTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAATTGGCT

>64944_64944_6_PHKB-VRK2_PHKB_chr16_47531399_ENST00000455779_VRK2_chr2_58313473_ENST00000435505_length(amino acids)=471AA_BP=48
MACSPDAVVSPSSAFLRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGID
LQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFT
SLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ
ALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQEST
RRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADV

--------------------------------------------------------------
>64944_64944_7_PHKB-VRK2_PHKB_chr16_47531399_ENST00000566044_VRK2_chr2_58313473_ENST00000417641_length(transcript)=1832nt_BP=334nt
CGGCATTGCTGACAGGCGGCCCCGGGGGCGGTGGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGA
GCTGGAAGGTCTTGGAGCGAAGAGCTCGGACCAAGCGCTCAGTTTTAAAATTGCTATAGCTTAGCCTGCGACGCTTATGATTAGAGCCAA
CAATTTGAAATGGCCTGCTCACCTGATGCAGTCGTCTCTCCGTCTTCCGCTTTCTTAAGGTCTGGCTCAGTTTATGAACCTCTTAAAAGC
ATTAATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTATTACAGAATTGTCAAAAAGTGGATAGAACGCAAACAA
CTTGATTATTTAGGAATTCCTCTGTTTTATGGATCTGGTCTGACTGAATTCAAGGGAAGAAGTTACAGATTTATGGTAATGGAAAGACTA
GGAATAGATTTACAGAAGATCTCAGGCCAGAATGGTACCTTTAAAAAGTCAACTGTCCTGCAATTAGGTATCCGAATGTTGGATGTACTG
GAATATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCTACTTTTGGGTTACAAAAATCCAGACCAGGTTTATCTT
GCAGATTATGGACTTTCCTACAGATATTGTCCCAATGGGAACCACAAACAGTATCAGGAAAATCCTAGAAAAGGCCATAATGGGACAATA
GAGTTTACCAGCTTGGATGCCCACAAGGGAGTAGCCTTGTCCAGACGAAGTGACGTTGAGATCCTCGGCTACTGCATGCTGCGGTGGTTG
TGTGGGAAACTTCCCTGGGAACAGAACCTGAAGGACCCTGTGGCTGTGCAGACTGCTAAAACAAATCTGTTGGACGAGCTCCCCCAGTCA
GTGCTTAAATGGGCTCCTTCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTTGGTATGTGCTCATAGTTTAGCATATGATGAAAAGCCA
AACTATCAAGCCCTCAAGAAAATTTTGAACCCTCATGGAATACCTTTAGGACCACTGGACTTTTCCACAAAAGGACAGAGTATAAATGTC
CATACTCCAAACAGTCAAAAAGTTGATTCACAAAAGGCTGCAACAAAGCAAGTCAACAAGGCACACAATAGGTTAATCGAAAAAAAAGTC
CACAGTGAGAGAAGCGCTGAGTCCTGTGCAACATGGAAAGTGCAGAAAGAGGAGAAACTGATTGGATTGATGAACAATGAAGCAGCTCAG
TTTAGGTAGAAGCTTAGGCTATTGATTTGAACCCACTATTTTTTCTAATGAAAGCACAAGGAGAAGACAGAAATATCAAGAGTCTCAAGA
ACCTTTGAATGAAGTAAACAGTTTCCCACAAAAAATCAGCTATACACAATTCCCAAACTCATTTTATGAGCCTCATCAAGATTTTACCAG
TCCAGATATATTCAAGAAGTCAAGATCTCCATCTTGGTATAAATACACTTCCACAGTCAGCACGGGGATCACAGACTTAGAAAGTTCAAC
TGGACTTTGGCCTACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAACGCAGATGTTTATTATTATCGCATCATCATACCTGTCCTTTT
GATGTTAGTATTTCTTGCTTTATTTTTTCTCTGAAGATGATACCAAAATTCCTTTTGATAATTTTTTAAGTTTCCAGCTCTTCACCGAAA
TGTTGTATTCTTATTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAATTGGCTTTAAAAAGAGAACATATTTTAACAAAGTTTGTGGACA

>64944_64944_7_PHKB-VRK2_PHKB_chr16_47531399_ENST00000566044_VRK2_chr2_58313473_ENST00000417641_length(amino acids)=359AA_BP=48
MACSPDAVVSPSSAFLRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGID
LQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFT
SLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ

--------------------------------------------------------------
>64944_64944_8_PHKB-VRK2_PHKB_chr16_47531399_ENST00000566044_VRK2_chr2_58313473_ENST00000435505_length(transcript)=1779nt_BP=334nt
CGGCATTGCTGACAGGCGGCCCCGGGGGCGGTGGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGA
GCTGGAAGGTCTTGGAGCGAAGAGCTCGGACCAAGCGCTCAGTTTTAAAATTGCTATAGCTTAGCCTGCGACGCTTATGATTAGAGCCAA
CAATTTGAAATGGCCTGCTCACCTGATGCAGTCGTCTCTCCGTCTTCCGCTTTCTTAAGGTCTGGCTCAGTTTATGAACCTCTTAAAAGC
ATTAATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTATTACAGAATTGTCAAAAAGTGGATAGAACGCAAACAA
CTTGATTATTTAGGAATTCCTCTGTTTTATGGATCTGGTCTGACTGAATTCAAGGGAAGAAGTTACAGATTTATGGTAATGGAAAGACTA
GGAATAGATTTACAGAAGATCTCAGGCCAGAATGGTACCTTTAAAAAGTCAACTGTCCTGCAATTAGGTATCCGAATGTTGGATGTACTG
GAATATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCTACTTTTGGGTTACAAAAATCCAGACCAGGTTTATCTT
GCAGATTATGGACTTTCCTACAGATATTGTCCCAATGGGAACCACAAACAGTATCAGGAAAATCCTAGAAAAGGCCATAATGGGACAATA
GAGTTTACCAGCTTGGATGCCCACAAGGGAGTAGCCTTGTCCAGACGAAGTGACGTTGAGATCCTCGGCTACTGCATGCTGCGGTGGTTG
TGTGGGAAACTTCCCTGGGAACAGAACCTGAAGGACCCTGTGGCTGTGCAGACTGCTAAAACAAATCTGTTGGACGAGCTCCCCCAGTCA
GTGCTTAAATGGGCTCCTTCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTTGGTATGTGCTCATAGTTTAGCATATGATGAAAAGCCA
AACTATCAAGCCCTCAAGAAAATTTTGAACCCTCATGGAATACCTTTAGGACCACTGGACTTTTCCACAAAAGGACAGAGTATAAATGTC
CATACTCCAAACAGTCAAAAAGTTGATTCACAAAAGGCTGCAACAAAGCAAGTCAACAAGGCACACAATAGGTTAATCGAAAAAAAAGTC
CACAGTGAGAGAAGCGCTGAGTCCTGTGCAACATGGAAAGTGCAGAAAGAGGAGAAACTGATTGGATTGATGAACAATGAAGCAGCTCAG
GAAAGCACAAGGAGAAGACAGAAATATCAAGAGTCTCAAGAACCTTTGAATGAAGTAAACAGTTTCCCACAAAAAATCAGCTATACACAA
TTCCCAAACTCATTTTATGAGCCTCATCAAGATTTTACCAGTCCAGATATATTCAAGAAGTCAAGATCTCCATCTTGGTATAAATACACT
TCCACAGTCAGCACGGGGATCACAGACTTAGAAAGTTCAACTGGACTTTGGCCTACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAAC
GCAGATGTTTATTATTATCGCATCATCATACCTGTCCTTTTGATGTTAGTATTTCTTGCTTTATTTTTTCTCTGAAGATGATACCAAAAT
TCCTTTTGATAATTTTTTAAGTTTCCAGCTCTTCACCGAAATGTTGTATTCTTATTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAATT

>64944_64944_8_PHKB-VRK2_PHKB_chr16_47531399_ENST00000566044_VRK2_chr2_58313473_ENST00000435505_length(amino acids)=471AA_BP=48
MACSPDAVVSPSSAFLRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGID
LQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFT
SLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ
ALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQEST
RRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PHKB-VRK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PHKB-VRK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PHKB-VRK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source