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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHLDB1-TAGLN (FusionGDB2 ID:64967)

Fusion Gene Summary for PHLDB1-TAGLN

check button Fusion gene summary
Fusion gene informationFusion gene name: PHLDB1-TAGLN
Fusion gene ID: 64967
HgeneTgene
Gene symbol

PHLDB1

TAGLN

Gene ID

23187

6876

Gene namepleckstrin homology like domain family B member 1transgelin
SynonymsLL5ASM22|SM22-alpha|SMCC|TAGLN1|WS3-10
Cytomap

11q23.3

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology-like domain family B member 1LL5alphapleckstrin homology-like domain family B member 1 variant 3pleckstrin homology-like domain family B member 1 variant 4protein LL5-alphatransgelin22 kDa actin-binding proteinepididymis secretory sperm binding proteinsmooth muscle protein 22-alphatransgelin variant 2
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000534672, ENST00000356063, 
ENST00000361417, ENST00000524713, 
ENST00000527898, 		ENST00000392951, 
ENST00000530649, ENST00000532870, 
Fusion gene scores* DoF score12 X 11 X 8=105610 X 10 X 5=500
# samples 1211
** MAII scorelog2(12/1056*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/500*10)=-2.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHLDB1 [Title/Abstract] AND TAGLN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHLDB1(118527495)-TAGLN(117074987), # samples:1
Anticipated loss of major functional domain due to fusion event.PHLDB1-TAGLN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PHLDB1-TAGLN seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAGLN

GO:0030855

epithelial cell differentiation

21492153


check buttonFusion gene breakpoints across PHLDB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TAGLN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW352228PHLDB1chr11

118527495

+TAGLNchr11

117074987

+


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Fusion Gene ORF analysis for PHLDB1-TAGLN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000534672ENST00000392951PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
3UTR-3CDSENST00000534672ENST00000530649PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
3UTR-3CDSENST00000534672ENST00000532870PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
Frame-shiftENST00000356063ENST00000392951PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
Frame-shiftENST00000356063ENST00000530649PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
Frame-shiftENST00000356063ENST00000532870PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
Frame-shiftENST00000361417ENST00000392951PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
Frame-shiftENST00000361417ENST00000530649PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
Frame-shiftENST00000361417ENST00000532870PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
Frame-shiftENST00000524713ENST00000532870PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
Frame-shiftENST00000527898ENST00000532870PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
In-frameENST00000524713ENST00000392951PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
In-frameENST00000524713ENST00000530649PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
In-frameENST00000527898ENST00000392951PHLDB1chr11

118527495

+TAGLNchr11

117074987

+
In-frameENST00000527898ENST00000530649PHLDB1chr11

118527495

+TAGLNchr11

117074987

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000527898PHLDB1chr11118527495+ENST00000392951TAGLNchr11117074987+196216762971652451
ENST00000527898PHLDB1chr11118527495+ENST00000530649TAGLNchr11117074987+218116762971652451
ENST00000524713PHLDB1chr11118527495+ENST00000392951TAGLNchr11117074987+17741488431464473
ENST00000524713PHLDB1chr11118527495+ENST00000530649TAGLNchr11117074987+19931488431464473

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000527898ENST00000392951PHLDB1chr11118527495+TAGLNchr11117074987+0.0437530060.95624703
ENST00000527898ENST00000530649PHLDB1chr11118527495+TAGLNchr11117074987+0.0358826440.9641174
ENST00000524713ENST00000392951PHLDB1chr11118527495+TAGLNchr11117074987+0.079928530.9200715
ENST00000524713ENST00000530649PHLDB1chr11118527495+TAGLNchr11117074987+0.080218930.91978115

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Fusion Genomic Features for PHLDB1-TAGLN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHLDB1-TAGLN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:118527495/chr11:117074987)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTAGLNchr11:118527495chr11:117074987ENST000003929510524_1370202.0DomainCalponin-homology (CH)
TgeneTAGLNchr11:118527495chr11:117074987ENST000005306490524_1370202.0DomainCalponin-homology (CH)
TgeneTAGLNchr11:118527495chr11:117074987ENST000005328700424_1370202.0DomainCalponin-homology (CH)
TgeneTAGLNchr11:118527495chr11:117074987ENST0000039295105175_2000202.0RepeatNote=Calponin-like
TgeneTAGLNchr11:118527495chr11:117074987ENST0000053064905175_2000202.0RepeatNote=Calponin-like
TgeneTAGLNchr11:118527495chr11:117074987ENST0000053287004175_2000202.0RepeatNote=Calponin-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHLDB1chr11:118527495chr11:117074987ENST00000356063+1211144_120801320.0Coiled coilOntology_term=ECO:0000255
HgenePHLDB1chr11:118527495chr11:117074987ENST00000356063+121683_80901320.0Coiled coilOntology_term=ECO:0000255
HgenePHLDB1chr11:118527495chr11:117074987ENST00000361417+1241144_120801378.0Coiled coilOntology_term=ECO:0000255
HgenePHLDB1chr11:118527495chr11:117074987ENST00000361417+124683_80901378.0Coiled coilOntology_term=ECO:0000255
HgenePHLDB1chr11:118527495chr11:117074987ENST00000356063+1211256_137001320.0DomainPH
HgenePHLDB1chr11:118527495chr11:117074987ENST00000356063+12164_12501320.0DomainNote=FHA
HgenePHLDB1chr11:118527495chr11:117074987ENST00000361417+1241256_137001378.0DomainPH
HgenePHLDB1chr11:118527495chr11:117074987ENST00000361417+12464_12501378.0DomainNote=FHA


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Fusion Gene Sequence for PHLDB1-TAGLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64967_64967_1_PHLDB1-TAGLN_PHLDB1_chr11_118527495_ENST00000524713_TAGLN_chr11_117074987_ENST00000392951_length(transcript)=1774nt_BP=1488nt
CTCTTATATTCCCTCCTGCGTCTGGCCTTGCTCCAAGTACGTGATGCTTGAGCAGCTAAAGGTGATGCGGGGCACCTCGCCCATGCCCCC
AGCCCCTGTGCCAGGCCTTTCTCCCTGGGCCTCCGCCTCCCGGGACCTGGTTCCCACCACCTGCCTTCCTCCCATGCTGCCCTCCTCCTC
GTTCGCTTCCATCACGCCTTCACCTAAGATGGAGAAGCTGCTGCTCCCTGCTGTAGACTTAGAGCAGTGGTACCAGGAGCTGATGGCCGG
GCTGGGGACTGGCCCCGCTGCAGCCTCCCCTCACTCTTCTCCCCCGCCTCTGCCCGCCAAAGCTTCCCGTCAGCTGCAGGTTTACCGCTC
CAAGATGGATGGCGAGGCCACCAGCCCCCTTCCCCGGACCCGCAGCGGCCCCCTCCCCTCCTCCTCTGGCTCTTCCTCCTCCTCCTCCCA
GCTCAGCGTGGCTACCCTGGGGCGTAGCCCCTCCCCAAAGAGCGCTCTACTCACCCAGAATGGCACGGGCAGCCTTCCTCGCAACCTGGC
AGCCACACTGCAGGACATCGAGACCAAGCGCCAACTAGCTCTGCAGCAGAAGGGACAACAAGTGATTGAAGAGCAGCGGCGGCGACTGGC
TGAGCTGAAGCAGAAAGCGGCAGCTGAGGCACAGTGCCAGTGGGATGCCCTTCACGGGGCAGCACCCTTCCCAGCGGGCCCCTCGGGCTT
CCCCCCTCTCATGCACCACTCTATCCTACACCACCTGCCTGCGGGGCGGGAGCGTGGGGAGGAGGGTGAGCACGCCTATGATACGCTGAG
TCTGGAGAGCTCTGACAGCATGGAGACCAGCATCTCCACCGGGGGCAACTCGGCCTGCTCCCCTGACAACATGTCCAGCGCGAGTGGTCT
GGACATGGGGAAGATCGAGGAGATGGAGAAGATGCTGAAAGAGGCTCATGCAGAGAAGAACCGGCTCATGGAGTCGAGGGAGCGGGAGAT
GGAGCTGCGGCGGCAGGCCCTGGAGGAGGAGCGGCGGAGGCGTGAGCAGGTAGAACGGAGGCTGCAGAGTGAGAGTGCCCGGAGGCAGCA
GCTGGTCGAGAAGGAGGTCAAGATGCGGGAGAAACAATTTTCCCAGGCACGACCCCTGACCCGCTACCTGCCAATCCGGAAGGAGGACTT
TGACCTGAAGACACATATTGAGTCATCGGGCCATGGTGTTGATACCTGCCTGCACGTGGTGCTCAGCAGCAAGGTCTGCCGTGGCTACTT
GGTCAAGATGGGCGGCAAGATTAAATCATGGAAGAAGCGCTGGTTTGTCTTCGACCGGCTCAAGCGCACCCTTTCCTATTATGTGGACAA
GCATGAGACGAAGCTGAAGGGAGTCATCTATTTCCAGGCCATTGAGGAAGTGTACTACGACCACCTGCGCAGTGCAGCCAAGTCACAGGG
GCTGAGGGCTACACTCAGTTCATGAACTAACTGCCGTGGGCCTCCTGGTGTCATTGGCCTTCAGATGGGCAGCAACAGAGGGGCCTCCCA
GGCCGGCATGACAGGCTACGGACGACCTCGGCAGATCATCAGTTAGAGCGGAGAGGGCTAGCCCTGAGCCCGGCCCTCCCCCAGCTCCTT
GGCTGCAGCCATCCCGCTTAGCCTGCCTCACCCACACCCGTGTGGTACCTTCAGCCCTGGCCAAGCTTTGAGGCTCTGTCACTGAGCAAT

>64967_64967_1_PHLDB1-TAGLN_PHLDB1_chr11_118527495_ENST00000524713_TAGLN_chr11_117074987_ENST00000392951_length(amino acids)=473AA_BP=
MLEQLKVMRGTSPMPPAPVPGLSPWASASRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSP
PPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI

--------------------------------------------------------------
>64967_64967_2_PHLDB1-TAGLN_PHLDB1_chr11_118527495_ENST00000524713_TAGLN_chr11_117074987_ENST00000530649_length(transcript)=1993nt_BP=1488nt
CTCTTATATTCCCTCCTGCGTCTGGCCTTGCTCCAAGTACGTGATGCTTGAGCAGCTAAAGGTGATGCGGGGCACCTCGCCCATGCCCCC
AGCCCCTGTGCCAGGCCTTTCTCCCTGGGCCTCCGCCTCCCGGGACCTGGTTCCCACCACCTGCCTTCCTCCCATGCTGCCCTCCTCCTC
GTTCGCTTCCATCACGCCTTCACCTAAGATGGAGAAGCTGCTGCTCCCTGCTGTAGACTTAGAGCAGTGGTACCAGGAGCTGATGGCCGG
GCTGGGGACTGGCCCCGCTGCAGCCTCCCCTCACTCTTCTCCCCCGCCTCTGCCCGCCAAAGCTTCCCGTCAGCTGCAGGTTTACCGCTC
CAAGATGGATGGCGAGGCCACCAGCCCCCTTCCCCGGACCCGCAGCGGCCCCCTCCCCTCCTCCTCTGGCTCTTCCTCCTCCTCCTCCCA
GCTCAGCGTGGCTACCCTGGGGCGTAGCCCCTCCCCAAAGAGCGCTCTACTCACCCAGAATGGCACGGGCAGCCTTCCTCGCAACCTGGC
AGCCACACTGCAGGACATCGAGACCAAGCGCCAACTAGCTCTGCAGCAGAAGGGACAACAAGTGATTGAAGAGCAGCGGCGGCGACTGGC
TGAGCTGAAGCAGAAAGCGGCAGCTGAGGCACAGTGCCAGTGGGATGCCCTTCACGGGGCAGCACCCTTCCCAGCGGGCCCCTCGGGCTT
CCCCCCTCTCATGCACCACTCTATCCTACACCACCTGCCTGCGGGGCGGGAGCGTGGGGAGGAGGGTGAGCACGCCTATGATACGCTGAG
TCTGGAGAGCTCTGACAGCATGGAGACCAGCATCTCCACCGGGGGCAACTCGGCCTGCTCCCCTGACAACATGTCCAGCGCGAGTGGTCT
GGACATGGGGAAGATCGAGGAGATGGAGAAGATGCTGAAAGAGGCTCATGCAGAGAAGAACCGGCTCATGGAGTCGAGGGAGCGGGAGAT
GGAGCTGCGGCGGCAGGCCCTGGAGGAGGAGCGGCGGAGGCGTGAGCAGGTAGAACGGAGGCTGCAGAGTGAGAGTGCCCGGAGGCAGCA
GCTGGTCGAGAAGGAGGTCAAGATGCGGGAGAAACAATTTTCCCAGGCACGACCCCTGACCCGCTACCTGCCAATCCGGAAGGAGGACTT
TGACCTGAAGACACATATTGAGTCATCGGGCCATGGTGTTGATACCTGCCTGCACGTGGTGCTCAGCAGCAAGGTCTGCCGTGGCTACTT
GGTCAAGATGGGCGGCAAGATTAAATCATGGAAGAAGCGCTGGTTTGTCTTCGACCGGCTCAAGCGCACCCTTTCCTATTATGTGGACAA
GCATGAGACGAAGCTGAAGGGAGTCATCTATTTCCAGGCCATTGAGGAAGTGTACTACGACCACCTGCGCAGTGCAGCCAAGTCACAGGG
GCTGAGGGCTACACTCAGTTCATGAACTAACTGCCGTGGGCCTCCTGGTGTCATTGGCCTTCAGATGGGCAGCAACAGAGGGGCCTCCCA
GGCCGGCATGACAGGCTACGGACGACCTCGGCAGATCATCAGTTAGAGCGGAGAGGGCTAGCCCTGAGCCCGGCCCTCCCCCAGCTCCTT
GGCTGCAGCCATCCCGCTTAGCCTGCCTCACCCACACCCGTGTGGTACCTTCAGCCCTGGCCAAGCTTTGAGGCTCTGTCACTGAGCAAT
GGTAACTGCACCTGGGCAGCTCCTCCCTGTGCCCCCAGCCTCAGCCCAACTTCTTACCCGAAAGCATCACTGCCTTGGCCCCTCCCTCCC
GGCTGCCCCCATCACCTCTACTGTCTCCTCCCTGGGCTAAGCAGGGGAGAAGCGGGCTGGGGGTAGCCTGGATGTGGGCCAAGTCCACTG
TCCTCCTTGGCGGCAAAAGCCCATTGAAGAAGAACCAGCCCAGCCTGCCCCCTATCTTGTCCTGGAATATTTTTGGGGTTGGAACTCAAA

>64967_64967_2_PHLDB1-TAGLN_PHLDB1_chr11_118527495_ENST00000524713_TAGLN_chr11_117074987_ENST00000530649_length(amino acids)=473AA_BP=
MLEQLKVMRGTSPMPPAPVPGLSPWASASRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSP
PPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI

--------------------------------------------------------------
>64967_64967_3_PHLDB1-TAGLN_PHLDB1_chr11_118527495_ENST00000527898_TAGLN_chr11_117074987_ENST00000392951_length(transcript)=1962nt_BP=1676nt
AGTGTCTCTAGGCTTTGGGACCCATTGGTTGTAGGGTAAGGGAAGGGAGATTTGAGGATCTGAGTGGTGTGCCTAATGGCACAGGGGTCA
TTGGTCAAGGGAGGGAGGGAGGCCCGAGGGAAGGAGCCCACATGGCAGCCTGTTTTCTTAGGGTGAGTTGAGGCCAAGCAGAAGAGCTGG
TTGATCCCCTTCACCTGAGCCTTGAGTGTCTGGGCAGGAGAGCCAGCTAGTTCTCACCTTGGGCTCAGCCCTGTCTCCCCAGGGCCTGAT
CAACCACCCCATCTCCTTTAGGAGCGCCTGGCCATCCTGGACAGTCAGGCTGGGCAGATCCGGGCTCAGGCCGTGCAGGAATCAGAACGC
CTGGCCCGGGACAAGAATGCCTCCTTACAGCTGCTGCAAAAGGAGAAGGAGAAGCTGACTGTGCTGGAAAGGAGATACCACTCACTCACA
GGGGGCAGGCCTTTCCCGAAGACCACATCGACCCTCAAAGAGGTTTACCGCTCCAAGATGGATGGCGAGGCCACCAGCCCCCTTCCCCGG
ACCCGCAGCGGCCCCCTCCCCTCCTCCTCTGGCTCTTCCTCCTCCTCCTCCCAGCTCAGCGTGGCTACCCTGGGGCGTAGCCCCTCCCCA
AAGAGCGCTCTACTCACCCAGAATGGCACGGGCAGCCTTCCTCGCAACCTGGCAGCCACACTGCAGGACATCGAGACCAAGCGCCAACTA
GCTCTGCAGCAGAAGGTCGAGTCGCTTCCCGCCGAGCCCCTCCCAACCGACGACCCAGCAGGACAACAAGTGATTGAAGAGCAGCGGCGG
CGACTGGCTGAGCTGAAGCAGAAAGCGGCAGCTGAGGCACAGTGCCAGTGGGATGCCCTTCACGGGGCAGCACCCTTCCCAGCGGGCCCC
TCGGGCTTCCCCCCTCTCATGCACCACTCTATCCTACACCACCTGCCTGCGGGGCGGGAGCGTGGGGAGGAGGGTGAGCACGCCTATGAT
ACGCTGAGTCTGGAGAGCTCTGACAGCATGGAGACCAGCATCTCCACCGGGGGCAACTCGGCCTGCTCCCCTGACAACATGTCCAGCGCG
AGTGGTCTGGACATGGGGAAGATCGAGGAGATGGAGAAGATGCTGAAAGAGGCTCATGCAGAGAAGAACCGGCTCATGGAGTCGAGGGAG
CGGGAGATGGAGCTGCGGCGGCAGGCCCTGGAGGAGGAGCGGCGGAGGCGTGAGCAGGTAGAACGGAGGCTGCAGAGTGAGAGTGCCCGG
AGGCAGCAGCTGGTCGAGAAGGAGGTCAAGATGCGGGAGAAACAATTTTCCCAGGCACGACCCCTGACCCGCTACCTGCCAATCCGGAAG
GAGGACTTTGACCTGAAGACACATATTGAGTCATCGGGCCATGGTGTTGATACCTGCCTGCACGTGGTGCTCAGCAGCAAGGTCTGCCGT
GGCTACTTGGTCAAGATGGGCGGCAAGATTAAATCATGGAAGAAGCGCTGGTTTGTCTTCGACCGGCTCAAGCGCACCCTTTCCTATTAT
GTGGACAAGCATGAGACGAAGCTGAAGGGAGTCATCTATTTCCAGGCCATTGAGGAAGTGTACTACGACCACCTGCGCAGTGCAGCCAAG
TCACAGGGGCTGAGGGCTACACTCAGTTCATGAACTAACTGCCGTGGGCCTCCTGGTGTCATTGGCCTTCAGATGGGCAGCAACAGAGGG
GCCTCCCAGGCCGGCATGACAGGCTACGGACGACCTCGGCAGATCATCAGTTAGAGCGGAGAGGGCTAGCCCTGAGCCCGGCCCTCCCCC
AGCTCCTTGGCTGCAGCCATCCCGCTTAGCCTGCCTCACCCACACCCGTGTGGTACCTTCAGCCCTGGCCAAGCTTTGAGGCTCTGTCAC

>64967_64967_3_PHLDB1-TAGLN_PHLDB1_chr11_118527495_ENST00000527898_TAGLN_chr11_117074987_ENST00000392951_length(amino acids)=451AA_BP=
MAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSS
SGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRRRLAELKQKA
AAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE
EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHI
ESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSQGLRATLS

--------------------------------------------------------------
>64967_64967_4_PHLDB1-TAGLN_PHLDB1_chr11_118527495_ENST00000527898_TAGLN_chr11_117074987_ENST00000530649_length(transcript)=2181nt_BP=1676nt
AGTGTCTCTAGGCTTTGGGACCCATTGGTTGTAGGGTAAGGGAAGGGAGATTTGAGGATCTGAGTGGTGTGCCTAATGGCACAGGGGTCA
TTGGTCAAGGGAGGGAGGGAGGCCCGAGGGAAGGAGCCCACATGGCAGCCTGTTTTCTTAGGGTGAGTTGAGGCCAAGCAGAAGAGCTGG
TTGATCCCCTTCACCTGAGCCTTGAGTGTCTGGGCAGGAGAGCCAGCTAGTTCTCACCTTGGGCTCAGCCCTGTCTCCCCAGGGCCTGAT
CAACCACCCCATCTCCTTTAGGAGCGCCTGGCCATCCTGGACAGTCAGGCTGGGCAGATCCGGGCTCAGGCCGTGCAGGAATCAGAACGC
CTGGCCCGGGACAAGAATGCCTCCTTACAGCTGCTGCAAAAGGAGAAGGAGAAGCTGACTGTGCTGGAAAGGAGATACCACTCACTCACA
GGGGGCAGGCCTTTCCCGAAGACCACATCGACCCTCAAAGAGGTTTACCGCTCCAAGATGGATGGCGAGGCCACCAGCCCCCTTCCCCGG
ACCCGCAGCGGCCCCCTCCCCTCCTCCTCTGGCTCTTCCTCCTCCTCCTCCCAGCTCAGCGTGGCTACCCTGGGGCGTAGCCCCTCCCCA
AAGAGCGCTCTACTCACCCAGAATGGCACGGGCAGCCTTCCTCGCAACCTGGCAGCCACACTGCAGGACATCGAGACCAAGCGCCAACTA
GCTCTGCAGCAGAAGGTCGAGTCGCTTCCCGCCGAGCCCCTCCCAACCGACGACCCAGCAGGACAACAAGTGATTGAAGAGCAGCGGCGG
CGACTGGCTGAGCTGAAGCAGAAAGCGGCAGCTGAGGCACAGTGCCAGTGGGATGCCCTTCACGGGGCAGCACCCTTCCCAGCGGGCCCC
TCGGGCTTCCCCCCTCTCATGCACCACTCTATCCTACACCACCTGCCTGCGGGGCGGGAGCGTGGGGAGGAGGGTGAGCACGCCTATGAT
ACGCTGAGTCTGGAGAGCTCTGACAGCATGGAGACCAGCATCTCCACCGGGGGCAACTCGGCCTGCTCCCCTGACAACATGTCCAGCGCG
AGTGGTCTGGACATGGGGAAGATCGAGGAGATGGAGAAGATGCTGAAAGAGGCTCATGCAGAGAAGAACCGGCTCATGGAGTCGAGGGAG
CGGGAGATGGAGCTGCGGCGGCAGGCCCTGGAGGAGGAGCGGCGGAGGCGTGAGCAGGTAGAACGGAGGCTGCAGAGTGAGAGTGCCCGG
AGGCAGCAGCTGGTCGAGAAGGAGGTCAAGATGCGGGAGAAACAATTTTCCCAGGCACGACCCCTGACCCGCTACCTGCCAATCCGGAAG
GAGGACTTTGACCTGAAGACACATATTGAGTCATCGGGCCATGGTGTTGATACCTGCCTGCACGTGGTGCTCAGCAGCAAGGTCTGCCGT
GGCTACTTGGTCAAGATGGGCGGCAAGATTAAATCATGGAAGAAGCGCTGGTTTGTCTTCGACCGGCTCAAGCGCACCCTTTCCTATTAT
GTGGACAAGCATGAGACGAAGCTGAAGGGAGTCATCTATTTCCAGGCCATTGAGGAAGTGTACTACGACCACCTGCGCAGTGCAGCCAAG
TCACAGGGGCTGAGGGCTACACTCAGTTCATGAACTAACTGCCGTGGGCCTCCTGGTGTCATTGGCCTTCAGATGGGCAGCAACAGAGGG
GCCTCCCAGGCCGGCATGACAGGCTACGGACGACCTCGGCAGATCATCAGTTAGAGCGGAGAGGGCTAGCCCTGAGCCCGGCCCTCCCCC
AGCTCCTTGGCTGCAGCCATCCCGCTTAGCCTGCCTCACCCACACCCGTGTGGTACCTTCAGCCCTGGCCAAGCTTTGAGGCTCTGTCAC
TGAGCAATGGTAACTGCACCTGGGCAGCTCCTCCCTGTGCCCCCAGCCTCAGCCCAACTTCTTACCCGAAAGCATCACTGCCTTGGCCCC
TCCCTCCCGGCTGCCCCCATCACCTCTACTGTCTCCTCCCTGGGCTAAGCAGGGGAGAAGCGGGCTGGGGGTAGCCTGGATGTGGGCCAA
GTCCACTGTCCTCCTTGGCGGCAAAAGCCCATTGAAGAAGAACCAGCCCAGCCTGCCCCCTATCTTGTCCTGGAATATTTTTGGGGTTGG

>64967_64967_4_PHLDB1-TAGLN_PHLDB1_chr11_118527495_ENST00000527898_TAGLN_chr11_117074987_ENST00000530649_length(amino acids)=451AA_BP=
MAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSS
SGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRRRLAELKQKA
AAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE
EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHI
ESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSQGLRATLS

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Fusion Gene PPI Analysis for PHLDB1-TAGLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHLDB1-TAGLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHLDB1-TAGLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource