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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PHLDB2-CD96 (FusionGDB2 ID:64971)

Fusion Gene Summary for PHLDB2-CD96

Fusion gene summary

Fusion gene information	Fusion gene name: PHLDB2-CD96
	Fusion gene ID: 64971
		Hgene	Tgene
	Gene symbol	PHLDB2	CD96
	Gene ID	90102	10225
	Gene name	pleckstrin homology like domain family B member 2	CD96 molecule
	Synonyms	LL5b\|LL5beta	TACTILE
	Cytomap	3q13.2	3q13.13-q13.2
	Type of gene	protein-coding	protein-coding
	Description	pleckstrin homology-like domain family B member 2LL5 betaprotein LL5-beta	T-cell surface protein tactileT cell activation, increased late expressioncell surface antigen CD96t cell-activated increased late expression protein
	Modification date	20200313	20200329
	UniProtAcc	.	P40200
	Ensembl transtripts involved in fusion gene	ENST00000393923, ENST00000393925, ENST00000412622, ENST00000431670, ENST00000470699, ENST00000477695, ENST00000478922, ENST00000481953, ENST00000495180,	ENST00000438817, ENST00000283285, ENST00000352690,
Fusion gene scores	* DoF score	12 X 11 X 7=924	6 X 7 X 6=252
	# samples	15	9
	** MAII score	log2(15/924*10)=-2.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PHLDB2 [Title/Abstract] AND CD96 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PHLDB2(111564782)-CD96(111366389), # samples:2 PHLDB2(111451550)-CD96(111384374), # samples:2 PHLDB2(111564782)-CD96(111366390), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CD96	GO:0007160	cell-matrix adhesion	17847009

Fusion gene breakpoints across PHLDB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CD96 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-BA-5555-01A	PHLDB2	chr3	111564782	-	CD96	chr3	111366390	+
ChimerDB4	HNSC	TCGA-BA-5555	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
ChimerDB4	HNSC	TCGA-BA-5555	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
ChimerDB4	HNSC	TCGA-CQ-A4CI	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
ChimerDB4	LUSC	TCGA-34-5236	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
ChimerDB4	LUSC	TCGA-51-6867-01A	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
ChimerDB4	UCS	TCGA-N8-A56S	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
ChimerDB4	UCS	TCGA-N8-A56S	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+

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Fusion Gene ORF analysis for PHLDB2-CD96

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000393923	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
5CDS-intron	ENST00000393923	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
5CDS-intron	ENST00000393923	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
5UTR-3CDS	ENST00000393923	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
5UTR-3CDS	ENST00000393923	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
5UTR-3CDS	ENST00000393923	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
5UTR-3CDS	ENST00000393923	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
5UTR-intron	ENST00000393923	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
5UTR-intron	ENST00000393923	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
5UTR-intron	ENST00000393923	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
5UTR-intron	ENST00000393923	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
5UTR-intron	ENST00000393923	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
In-frame	ENST00000393923	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
In-frame	ENST00000393923	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
In-frame	ENST00000393923	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
In-frame	ENST00000393923	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
In-frame	ENST00000393923	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
In-frame	ENST00000393923	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000393925	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000393925	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000393925	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000393925	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000393925	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000393925	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000393925	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000393925	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000393925	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000393925	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000412622	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000412622	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000412622	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000412622	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000412622	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000412622	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000412622	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000412622	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000412622	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000412622	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000431670	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000431670	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000431670	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000431670	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000431670	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000431670	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000431670	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000431670	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000431670	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000431670	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000470699	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000470699	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000470699	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000470699	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000470699	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000470699	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000470699	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000470699	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000470699	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000470699	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000477695	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000477695	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000477695	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000477695	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000477695	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000477695	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000477695	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000477695	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000477695	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000477695	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000478922	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000478922	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000478922	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000478922	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000478922	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000478922	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000478922	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000478922	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000478922	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000478922	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000481953	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000481953	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000481953	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000481953	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000481953	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000481953	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000481953	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000481953	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000481953	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000481953	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000495180	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000495180	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000495180	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000495180	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000495180	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-3CDS	ENST00000495180	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-3CDS	ENST00000495180	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-3CDS	ENST00000495180	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-3CDS	ENST00000495180	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-3CDS	ENST00000495180	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-intron	ENST00000393925	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000393925	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000393925	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-intron	ENST00000393925	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-intron	ENST00000393925	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000393925	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-intron	ENST00000393925	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-intron	ENST00000393925	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-intron	ENST00000412622	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000412622	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000412622	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-intron	ENST00000412622	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-intron	ENST00000412622	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000412622	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-intron	ENST00000412622	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-intron	ENST00000412622	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-intron	ENST00000431670	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000431670	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000431670	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-intron	ENST00000431670	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-intron	ENST00000431670	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000431670	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-intron	ENST00000431670	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-intron	ENST00000431670	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-intron	ENST00000470699	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000470699	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000470699	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-intron	ENST00000470699	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-intron	ENST00000470699	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000470699	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-intron	ENST00000470699	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-intron	ENST00000470699	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-intron	ENST00000477695	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000477695	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000477695	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-intron	ENST00000477695	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-intron	ENST00000477695	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000477695	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-intron	ENST00000477695	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-intron	ENST00000477695	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-intron	ENST00000478922	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000478922	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000478922	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-intron	ENST00000478922	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-intron	ENST00000478922	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000478922	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-intron	ENST00000478922	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-intron	ENST00000478922	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-intron	ENST00000481953	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000481953	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000481953	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-intron	ENST00000481953	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-intron	ENST00000481953	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000481953	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-intron	ENST00000481953	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-intron	ENST00000481953	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+
intron-intron	ENST00000495180	ENST00000283285	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000495180	ENST00000352690	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000495180	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+
intron-intron	ENST00000495180	ENST00000438817	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+
intron-intron	ENST00000495180	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111384374	+
intron-intron	ENST00000495180	ENST00000438817	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+
intron-intron	ENST00000495180	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+
intron-intron	ENST00000495180	ENST00000438817	PHLDB2	chr3	111451550	+	CD96	chr3	111342601	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393923	PHLDB2	chr3	111564782	+	ENST00000352690	CD96	chr3	111366389	+	3121	322	1056	673	127
ENST00000393923	PHLDB2	chr3	111564782	+	ENST00000283285	CD96	chr3	111366389	+	2990	322	1056	673	127
ENST00000393923	PHLDB2	chr3	111564782	+	ENST00000352690	CD96	chr3	111366390	+	3121	322	1056	673	127
ENST00000393923	PHLDB2	chr3	111564782	+	ENST00000283285	CD96	chr3	111366390	+	2990	322	1056	673	127
ENST00000393923	PHLDB2	chr3	111564782	-	ENST00000352690	CD96	chr3	111342601	+	3418	322	252	851	199
ENST00000393923	PHLDB2	chr3	111564782	-	ENST00000283285	CD96	chr3	111342601	+	3287	322	252	851	199

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393923	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+	0.03423453	0.9657655
ENST00000393923	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+	0.07814615	0.92185384
ENST00000393923	ENST00000352690	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+	0.03423453	0.9657655
ENST00000393923	ENST00000283285	PHLDB2	chr3	111564782	+	CD96	chr3	111366390	+	0.07814615	0.92185384
ENST00000393923	ENST00000352690	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+	0.003455011	0.996545
ENST00000393923	ENST00000283285	PHLDB2	chr3	111564782	-	CD96	chr3	111342601	+	0.003733604	0.9962664

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Fusion Genomic Features for PHLDB2-CD96

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+	0.000381245	0.99961877
PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+	5.90E-06	0.99999404
PHLDB2	chr3	111451550	+	CD96	chr3	111342600	+	0.000381245	0.99961877
PHLDB2	chr3	111564782	+	CD96	chr3	111366389	+	5.90E-06	0.99999404

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PHLDB2-CD96

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:111564782/chr3:111366389)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CD96 P40200
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000283285

554_563

409

586.0

Compositional bias

Note=Pro-rich

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000352690

554_563

393

570.0

Compositional bias

Note=Pro-rich

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000283285

554_563

508

586.0

Compositional bias

Note=Pro-rich

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000352690

554_563

492

570.0

Compositional bias

Note=Pro-rich

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000283285

554_563

508

586.0

Compositional bias

Note=Pro-rich

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000352690

554_563

492

570.0

Compositional bias

Note=Pro-rich

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000283285

541_585

409

586.0

Topological domain

Cytoplasmic

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000352690

541_585

393

570.0

Topological domain

Cytoplasmic

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000283285

541_585

508

586.0

Topological domain

Cytoplasmic

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000352690

541_585

492

570.0

Topological domain

Cytoplasmic

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000283285

541_585

508

586.0

Topological domain

Cytoplasmic

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000352690

541_585

492

570.0

Topological domain

Cytoplasmic

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000283285

520_540

409

586.0

Transmembrane

Helical

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000352690

520_540

393

570.0

Transmembrane

Helical

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000283285

520_540

508

586.0

Transmembrane

Helical

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000352690

520_540

492

570.0

Transmembrane

Helical

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000283285

520_540

508

586.0

Transmembrane

Helical

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000352690

520_540

492

570.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000393923

1032_1098

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000393923

584_696

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000393923

722_807

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000393925

1032_1098

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000393925

584_696

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000393925

722_807

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000412622

1032_1098

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000412622

584_696

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000412622

722_807

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000431670

1032_1098

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000431670

584_696

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000431670

722_807

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000481953

1032_1098

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000481953

584_696

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000481953

722_807

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000393923

1032_1098

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000393923

584_696

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000393923

722_807

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000393925

1032_1098

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000393925

584_696

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000393925

722_807

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000412622

1032_1098

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000412622

584_696

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000412622

722_807

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000431670

1032_1098

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000431670

584_696

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000431670

722_807

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000481953

1032_1098

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000481953

584_696

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000481953

722_807

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000393923

1032_1098

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000393923

584_696

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000393923

722_807

1238.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000393925

1032_1098

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000393925

584_696

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000393925

722_807

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000412622

1032_1098

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000412622

584_696

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000412622

722_807

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000431670

1032_1098

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000431670

584_696

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000431670

722_807

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000481953

1032_1098

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000481953

584_696

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000481953

722_807

1211.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000393923

1143_1246

1238.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000393925

1143_1246

1254.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000412622

1143_1246

1211.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000431670

1143_1246

1254.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111342601

ENST00000481953

1143_1246

1211.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000393923

1143_1246

1238.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000393925

1143_1246

1254.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000412622

1143_1246

1211.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000431670

1143_1246

1254.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366389

ENST00000481953

1143_1246

1211.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000393923

1143_1246

1238.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000393925

1143_1246

1254.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000412622

1143_1246

1211.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000431670

1143_1246

1254.0

Domain

Hgene

PHLDB2

chr3:111564782

chr3:111366390

ENST00000481953

1143_1246

1211.0

Domain

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000283285

370_502

409

586.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000352690

370_502

393

570.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000283285

370_502

508

586.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000352690

370_502

492

570.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000283285

370_502

508

586.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000352690

370_502

492

570.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000283285

156_238

409

586.0

Domain

Note=Ig-like V-type 2

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000283285

269_375

409

586.0

Domain

Note=Ig-like C2-type

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000283285

38_125

409

586.0

Domain

Note=Ig-like V-type 1

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000352690

156_238

393

570.0

Domain

Note=Ig-like V-type 2

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000352690

269_375

393

570.0

Domain

Note=Ig-like C2-type

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000352690

38_125

393

570.0

Domain

Note=Ig-like V-type 1

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000283285

156_238

508

586.0

Domain

Note=Ig-like V-type 2

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000283285

269_375

508

586.0

Domain

Note=Ig-like C2-type

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000283285

38_125

508

586.0

Domain

Note=Ig-like V-type 1

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000352690

156_238

492

570.0

Domain

Note=Ig-like V-type 2

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000352690

269_375

492

570.0

Domain

Note=Ig-like C2-type

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000352690

38_125

492

570.0

Domain

Note=Ig-like V-type 1

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000283285

156_238

508

586.0

Domain

Note=Ig-like V-type 2

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000283285

269_375

508

586.0

Domain

Note=Ig-like C2-type

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000283285

38_125

508

586.0

Domain

Note=Ig-like V-type 1

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000352690

156_238

492

570.0

Domain

Note=Ig-like V-type 2

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000352690

269_375

492

570.0

Domain

Note=Ig-like C2-type

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000352690

38_125

492

570.0

Domain

Note=Ig-like V-type 1

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000283285

22_519

409

586.0

Topological domain

Extracellular

Tgene

CD96

chr3:111564782

chr3:111342601

ENST00000352690

22_519

393

570.0

Topological domain

Extracellular

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000283285

22_519

508

586.0

Topological domain

Extracellular

Tgene

CD96

chr3:111564782

chr3:111366389

ENST00000352690

22_519

492

570.0

Topological domain

Extracellular

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000283285

22_519

508

586.0

Topological domain

Extracellular

Tgene

CD96

chr3:111564782

chr3:111366390

ENST00000352690

22_519

492

570.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for PHLDB2-CD96

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>64971_64971_1_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111342601_ENST00000283285_length(transcript)=3287nt_BP=322nt
TGACCACAGTCTGCAGAGGCCAGAGAGAGCAGGAAAGGAAATGGAAAGGAACCTCACCTTCATGCTTGGGGAAAAGGAGAAACCTGTGTT
AATGTGTCTTCCCAACATCCCACTCTCTTCAGCAATCGCTGGAACAGCCATGGGCCATCCCTGCTGAGTCAGGAAAGAAGCTGAGGGAAG
AGTCGGGATTGAAAAGCAGCAGACAAGGCTGGCACTGATCCCAGTTTATCCTTTGAGATTCAGCAGAAGATCCTGATGGAGGAGGAGGAT
ACCAAGAGAGAGGTGCCCAAGGAAGATGGAGTTGGTGATGTGCAACATTTCGGATATCCAGCTACATCTTCAGTGACCCTTGTAGATGTG
AGTGCCTTGAGGCCAAACACCACTCCTCAACCCAGCAATTCCAGTATGACTACCCGAGGCTTCAACTATCCCTGGACCTCCAGTGGGACA
GATACCAAAAAATCAGTTTCACGGATACCTAGTGAAACATACAGTTCATCCCCGTCAGGTGCAGGCTCAACACTTCATGACAATGTCTTT
ACCAGCACAGCCAGAGCATTTTCAGAAGTCCCCACAACTGCCAATGGATCTACGAAAACTAATCACGTCCATATCACTGGTATTGTGGTC
AATAAGCCCAAAGATGGAATGTCCTGGCCAGTGATTGTAGCAGCTTTACTCTTTTGCTGCATGATATTGTTTGGTCTTGGAGTGAGAAAA
TGGTGTCAGTACCAAAAAGAAATAATGGAAAGACCTCCACCTTTCAAGCCACCACCACCTCCCATCAAGTACACTTGCATTCAAGAGCCC
AACGAAAGTGATCTGCCTTATCATGAGATGGAGACCCTCTAGTCTCGTGAGACTTTGCCCCATGGCAGAACTCTGCTGGAATCCTATTGA
GAAGGTAGACATTGTGCTTTATTAATATAGTCGCTCTTCAGCCATGCCTTTGCTGCAGCTGAAATGGAAGTCAGAAGTGAGTGACCTGTT
TTCCCAGCAACTCACCCTCTTCCATCTCCAAACGCCTGAAGCTTAACCAAGAGTGAGAGGATATGTCATGTTCACACTCAATGCAATTCG
TAGTGGTTTTCTTGCTTATGTAAGAAGTACATATTAGTCTGCCATCTTTAAAAAAAAATACAGTATTTTCATTTAAATTCTCTGATGGAG
GGACAACAATGGTTTCAACTGTATGCCCATGCCTGATCCTCTTATTTGAACATCTATCAACATTGTAAACTCTTTGCCAAAATCCTGGGG
CTTTGCTGCATTCCCTAAGATAATTACAGGAAAAAGAAAATGTAAAAGTGCTAACAAGGCTGCCAAGTAATGGAGAAGTATGGTTAGTCT
TCATATTGAAATTCTGTTGCTTATTTTCATGGAAGGAAACAGAATACTTTGCACAGGAACCACATTTTCAATCCTCCTTCACTGTCTTCC
TACCATGTTCAGCCCAGACTCCTGCCACATGGACCAGGATGAAGAGGGATCAAAGAGATAATTAGCCAAAAACCCAGTAGCCTAGAAGAT
ACAAAACTCCACTGGCCTCTAAAATTATATTAGCCAAGAGTGGTTTCATTTGAGTGCCTTCGTGTGTATGTCCATCAAACTGGAACCAAA
CTGTTTTGTAAGTAAACAGGCAGCCTAAGCCCAACCCTACTTTCTAATTCCAGTTATTCTCTTTTTCATCTGGGGATTTACCTGTTCATT
TAATCTGCCTGTTTTGATCTGTTTTGAAAAAGATAAAGAGCCTCAAATCAGACCAGCACTGATTAATTAACCCTGCTCCTACCAATCTTT
TTTAAAGCAGTTGAAGCAGAATGTATAGGTGTCAGAGAAGAAACCTAGTCAGCCAGACGTGCTCTGTATTCAGCAATAGTTTGTGAATGA
ATAAATTACTAATCCTCCTTGTCGCTTGAAACCTTCCCACACTCCCTGCTCCAGGAGGGAAAAACAGATGTTGTTGACAGATAGAGTGAT
AGGCAAATTCTGTGTGGACTTTAGTCCCAAAAGGAAACTTTAGTTCACTTGCAGTATGCTTATCCTTGACTGCACATGAGAATGCCTTGT
GCAGAGTTATTTGGAGATTATGTCTTTTTCTTAAACACCATGGCTGTCACACTTCAGTTCAATTAAATCAGAATGTCTGAGGAGTGAGAC
ACAGGCATCAACACTCTCAAATGATTCACATGTTCAGCCAAAGTTGAGAACCATCGAGCCTGTGGAAGTTCTTTCTCATGGCTCAGAATC
TTAGGTAGGTGCTTAACTCTTGTGGTGGCCAGCCTCCAAGATGAGCCCCAGTGTTCTTGCCTCCTACTATTCACATCTTTATGTGGTCCC
CTCCAATGCTGAATACAGATGATTTGTGTAACCTGAGGCCAGGATTAAGGGGAGGCAATCAATGCACCTAGGGAAAAAATTTAAGGAGGT
ATTCACACTCAGGGTCATGCACTTGCACAATGTTGAGAATGAGTACCACTCTCACCATTGGTATAGCCAAAAAAGCTTGGAAGTGACCAA
GGCTAGGTCACAAAATACACTGTGGCTTCTTCTTTGATCTCTCTTTGACCATACTGACACTGGGAAAAGCCCATTCCCATGCCATGAAGA
CACCAAGGCAGCCCTATTGAGAAATCTACCTGTCGTGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTG
GGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGT
GGTGTCGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAAGGGTGGGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGA
TTGTGCCACTGCACACTCCAATCTGGGTGAAAGACCGAGACTCCGCCTCAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAAAT
CTACCTGTCAAGGAACTAAGGTATTTTGCTAACAAGCACCAACTTGCCAGCCATGTAAGGGAGCCATCTTGGAAGCAGATCCTCCAGCCT
CCAGTCAAGTCTTCAGATAATTGCAACTTCAGTTGATCTTTTGACCAAGACCTCAAGAGAGCCAGAACTACCCAGCTAAGCCTTTTACTA
AATTTCTGAACTTCTAACACTATTAGATAATAAGTGCTTATTGTTTAACACCATTAATTTTGAGTATAATTTGTTACATAGCGACAGATA

>64971_64971_1_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111342601_ENST00000283285_length(amino acids)=199AA_BP=23
MMEEEDTKREVPKEDGVGDVQHFGYPATSSVTLVDVSALRPNTTPQPSNSSMTTRGFNYPWTSSGTDTKKSVSRIPSETYSSSPSGAGST
LHDNVFTSTARAFSEVPTTANGSTKTNHVHITGIVVNKPKDGMSWPVIVAALLFCCMILFGLGVRKWCQYQKEIMERPPPFKPPPPPIKY

--------------------------------------------------------------
>64971_64971_2_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111342601_ENST00000352690_length(transcript)=3418nt_BP=322nt
TGACCACAGTCTGCAGAGGCCAGAGAGAGCAGGAAAGGAAATGGAAAGGAACCTCACCTTCATGCTTGGGGAAAAGGAGAAACCTGTGTT
AATGTGTCTTCCCAACATCCCACTCTCTTCAGCAATCGCTGGAACAGCCATGGGCCATCCCTGCTGAGTCAGGAAAGAAGCTGAGGGAAG
AGTCGGGATTGAAAAGCAGCAGACAAGGCTGGCACTGATCCCAGTTTATCCTTTGAGATTCAGCAGAAGATCCTGATGGAGGAGGAGGAT
ACCAAGAGAGAGGTGCCCAAGGAAGATGGAGTTGGTGATGTGCAACATTTCGGATATCCAGCTACATCTTCAGTGACCCTTGTAGATGTG
AGTGCCTTGAGGCCAAACACCACTCCTCAACCCAGCAATTCCAGTATGACTACCCGAGGCTTCAACTATCCCTGGACCTCCAGTGGGACA
GATACCAAAAAATCAGTTTCACGGATACCTAGTGAAACATACAGTTCATCCCCGTCAGGTGCAGGCTCAACACTTCATGACAATGTCTTT
ACCAGCACAGCCAGAGCATTTTCAGAAGTCCCCACAACTGCCAATGGATCTACGAAAACTAATCACGTCCATATCACTGGTATTGTGGTC
AATAAGCCCAAAGATGGAATGTCCTGGCCAGTGATTGTAGCAGCTTTACTCTTTTGCTGCATGATATTGTTTGGTCTTGGAGTGAGAAAA
TGGTGTCAGTACCAAAAAGAAATAATGGAAAGACCTCCACCTTTCAAGCCACCACCACCTCCCATCAAGTACACTTGCATTCAAGAGCCC
AACGAAAGTGATCTGCCTTATCATGAGATGGAGACCCTCTAGTCTCGTGAGACTTTGCCCCATGGCAGAACTCTGCTGGAATCCTATTGA
GAAGGTAGACATTGTGCTTTATTAATATAGTCGCTCTTCAGCCATGCCTTTGCTGCAGCTGAAATGGAAGTCAGAAGTGAGTGACCTGTT
TTCCCAGCAACTCACCCTCTTCCATCTCCAAACGCCTGAAGCTTAACCAAGAGTGAGAGGATATGTCATGTTCACACTCAATGCAATTCG
TAGTGGTTTTCTTGCTTATGTAAGAAGTACATATTAGTCTGCCATCTTTAAAAAAAAATACAGTATTTTCATTTAAATTCTCTGATGGAG
GGACAACAATGGTTTCAACTGTATGCCCATGCCTGATCCTCTTATTTGAACATCTATCAACATTGTAAACTCTTTGCCAAAATCCTGGGG
CTTTGCTGCATTCCCTAAGATAATTACAGGAAAAAGAAAATGTAAAAGTGCTAACAAGGCTGCCAAGTAATGGAGAAGTATGGTTAGTCT
TCATATTGAAATTCTGTTGCTTATTTTCATGGAAGGAAACAGAATACTTTGCACAGGAACCACATTTTCAATCCTCCTTCACTGTCTTCC
TACCATGTTCAGCCCAGACTCCTGCCACATGGACCAGGATGAAGAGGGATCAAAGAGATAATTAGCCAAAAACCCAGTAGCCTAGAAGAT
ACAAAACTCCACTGGCCTCTAAAATTATATTAGCCAAGAGTGGTTTCATTTGAGTGCCTTCGTGTGTATGTCCATCAAACTGGAACCAAA
CTGTTTTGTAAGTAAACAGGCAGCCTAAGCCCAACCCTACTTTCTAATTCCAGTTATTCTCTTTTTCATCTGGGGATTTACCTGTTCATT
TAATCTGCCTGTTTTGATCTGTTTTGAAAAAGATAAAGAGCCTCAAATCAGACCAGCACTGATTAATTAACCCTGCTCCTACCAATCTTT
TTTAAAGCAGTTGAAGCAGAATGTATAGGTGTCAGAGAAGAAACCTAGTCAGCCAGACGTGCTCTGTATTCAGCAATAGTTTGTGAATGA
ATAAATTACTAATCCTCCTTGTCGCTTGAAACCTTCCCACACTCCCTGCTCCAGGAGGGAAAAACAGATGTTGTTGACAGATAGAGTGAT
AGGCAAATTCTGTGTGGACTTTAGTCCCAAAAGGAAACTTTAGTTCACTTGCAGTATGCTTATCCTTGACTGCACATGAGAATGCCTTGT
GCAGAGTTATTTGGAGATTATGTCTTTTTCTTAAACACCATGGCTGTCACACTTCAGTTCAATTAAATCAGAATGTCTGAGGAGTGAGAC
ACAGGCATCAACACTCTCAAATGATTCACATGTTCAGCCAAAGTTGAGAACCATCGAGCCTGTGGAAGTTCTTTCTCATGGCTCAGAATC
TTAGGTAGGTGCTTAACTCTTGTGGTGGCCAGCCTCCAAGATGAGCCCCAGTGTTCTTGCCTCCTACTATTCACATCTTTATGTGGTCCC
CTCCAATGCTGAATACAGATGATTTGTGTAACCTGAGGCCAGGATTAAGGGGAGGCAATCAATGCACCTAGGGAAAAAATTTAAGGAGGT
ATTCACACTCAGGGTCATGCACTTGCACAATGTTGAGAATGAGTACCACTCTCACCATTGGTATAGCCAAAAAAGCTTGGAAGTGACCAA
GGCTAGGTCACAAAATACACTGTGGCTTCTTCTTTGATCTCTCTTTGACCATACTGACACTGGGAAAAGCCCATTCCCATGCCATGAAGA
CACCAAGGCAGCCCTATTGAGAAATCTACCTGTCGTGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTG
GGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGT
GGTGTCGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAAGGGTGGGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGA
TTGTGCCACTGCACACTCCAATCTGGGTGAAAGACCGAGACTCCGCCTCAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAAAT
CTACCTGTCAAGGAACTAAGGTATTTTGCTAACAAGCACCAACTTGCCAGCCATGTAAGGGAGCCATCTTGGAAGCAGATCCTCCAGCCT
CCAGTCAAGTCTTCAGATAATTGCAACTTCAGTTGATCTTTTGACCAAGACCTCAAGAGAGCCAGAACTACCCAGCTAAGCCTTTTACTA
AATTTCTGAACTTCTAACACTATTAGATAATAAGTGCTTATTGTTTAACACCATTAATTTTGAGTATAATTTGTTACATAGCGACAGATA
ACTATACAGCTCAACAACTAGAAAAATAAACTGTTTACCTGCCTTAATTATTTATCTTTAGTTCCTTATTAGTTCTCAAGAAACAAATGC

>64971_64971_2_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111342601_ENST00000352690_length(amino acids)=199AA_BP=23
MMEEEDTKREVPKEDGVGDVQHFGYPATSSVTLVDVSALRPNTTPQPSNSSMTTRGFNYPWTSSGTDTKKSVSRIPSETYSSSPSGAGST
LHDNVFTSTARAFSEVPTTANGSTKTNHVHITGIVVNKPKDGMSWPVIVAALLFCCMILFGLGVRKWCQYQKEIMERPPPFKPPPPPIKY

--------------------------------------------------------------
>64971_64971_3_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111366389_ENST00000283285_length(transcript)=2990nt_BP=322nt
TGACCACAGTCTGCAGAGGCCAGAGAGAGCAGGAAAGGAAATGGAAAGGAACCTCACCTTCATGCTTGGGGAAAAGGAGAAACCTGTGTT
AATGTGTCTTCCCAACATCCCACTCTCTTCAGCAATCGCTGGAACAGCCATGGGCCATCCCTGCTGAGTCAGGAAAGAAGCTGAGGGAAG
AGTCGGGATTGAAAAGCAGCAGACAAGGCTGGCACTGATCCCAGTTTATCCTTTGAGATTCAGCAGAAGATCCTGATGGAGGAGGAGGAT
ACCAAGAGAGAGGTGCCCAAGGAAGATGGAGTTGGTGATGTGCAACATTTCGGTATTGTGGTCAATAAGCCCAAAGATGGAATGTCCTGG
CCAGTGATTGTAGCAGCTTTACTCTTTTGCTGCATGATATTGTTTGGTCTTGGAGTGAGAAAATGGTGTCAGTACCAAAAAGAAATAATG
GAAAGACCTCCACCTTTCAAGCCACCACCACCTCCCATCAAGTACACTTGCATTCAAGAGCCCAACGAAAGTGATCTGCCTTATCATGAG
ATGGAGACCCTCTAGTCTCGTGAGACTTTGCCCCATGGCAGAACTCTGCTGGAATCCTATTGAGAAGGTAGACATTGTGCTTTATTAATA
TAGTCGCTCTTCAGCCATGCCTTTGCTGCAGCTGAAATGGAAGTCAGAAGTGAGTGACCTGTTTTCCCAGCAACTCACCCTCTTCCATCT
CCAAACGCCTGAAGCTTAACCAAGAGTGAGAGGATATGTCATGTTCACACTCAATGCAATTCGTAGTGGTTTTCTTGCTTATGTAAGAAG
TACATATTAGTCTGCCATCTTTAAAAAAAAATACAGTATTTTCATTTAAATTCTCTGATGGAGGGACAACAATGGTTTCAACTGTATGCC
CATGCCTGATCCTCTTATTTGAACATCTATCAACATTGTAAACTCTTTGCCAAAATCCTGGGGCTTTGCTGCATTCCCTAAGATAATTAC
AGGAAAAAGAAAATGTAAAAGTGCTAACAAGGCTGCCAAGTAATGGAGAAGTATGGTTAGTCTTCATATTGAAATTCTGTTGCTTATTTT
CATGGAAGGAAACAGAATACTTTGCACAGGAACCACATTTTCAATCCTCCTTCACTGTCTTCCTACCATGTTCAGCCCAGACTCCTGCCA
CATGGACCAGGATGAAGAGGGATCAAAGAGATAATTAGCCAAAAACCCAGTAGCCTAGAAGATACAAAACTCCACTGGCCTCTAAAATTA
TATTAGCCAAGAGTGGTTTCATTTGAGTGCCTTCGTGTGTATGTCCATCAAACTGGAACCAAACTGTTTTGTAAGTAAACAGGCAGCCTA
AGCCCAACCCTACTTTCTAATTCCAGTTATTCTCTTTTTCATCTGGGGATTTACCTGTTCATTTAATCTGCCTGTTTTGATCTGTTTTGA
AAAAGATAAAGAGCCTCAAATCAGACCAGCACTGATTAATTAACCCTGCTCCTACCAATCTTTTTTAAAGCAGTTGAAGCAGAATGTATA
GGTGTCAGAGAAGAAACCTAGTCAGCCAGACGTGCTCTGTATTCAGCAATAGTTTGTGAATGAATAAATTACTAATCCTCCTTGTCGCTT
GAAACCTTCCCACACTCCCTGCTCCAGGAGGGAAAAACAGATGTTGTTGACAGATAGAGTGATAGGCAAATTCTGTGTGGACTTTAGTCC
CAAAAGGAAACTTTAGTTCACTTGCAGTATGCTTATCCTTGACTGCACATGAGAATGCCTTGTGCAGAGTTATTTGGAGATTATGTCTTT
TTCTTAAACACCATGGCTGTCACACTTCAGTTCAATTAAATCAGAATGTCTGAGGAGTGAGACACAGGCATCAACACTCTCAAATGATTC
ACATGTTCAGCCAAAGTTGAGAACCATCGAGCCTGTGGAAGTTCTTTCTCATGGCTCAGAATCTTAGGTAGGTGCTTAACTCTTGTGGTG
GCCAGCCTCCAAGATGAGCCCCAGTGTTCTTGCCTCCTACTATTCACATCTTTATGTGGTCCCCTCCAATGCTGAATACAGATGATTTGT
GTAACCTGAGGCCAGGATTAAGGGGAGGCAATCAATGCACCTAGGGAAAAAATTTAAGGAGGTATTCACACTCAGGGTCATGCACTTGCA
CAATGTTGAGAATGAGTACCACTCTCACCATTGGTATAGCCAAAAAAGCTTGGAAGTGACCAAGGCTAGGTCACAAAATACACTGTGGCT
TCTTCTTTGATCTCTCTTTGACCATACTGACACTGGGAAAAGCCCATTCCCATGCCATGAAGACACCAAGGCAGCCCTATTGAGAAATCT
ACCTGTCGTGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGATCGAG
ACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGTCGGGCACCTGTAGTCCCAGCTA
CTCAGGAGGCTGAGGCAGGAGAAGGGTGGGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACACTCCAATCTGGG
TGAAAGACCGAGACTCCGCCTCAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAAATCTACCTGTCAAGGAACTAAGGTATTTT
GCTAACAAGCACCAACTTGCCAGCCATGTAAGGGAGCCATCTTGGAAGCAGATCCTCCAGCCTCCAGTCAAGTCTTCAGATAATTGCAAC
TTCAGTTGATCTTTTGACCAAGACCTCAAGAGAGCCAGAACTACCCAGCTAAGCCTTTTACTAAATTTCTGAACTTCTAACACTATTAGA
TAATAAGTGCTTATTGTTTAACACCATTAATTTTGAGTATAATTTGTTACATAGCGACAGATAACTATACAGCTCAACAACTAGAAAAAT

>64971_64971_3_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111366389_ENST00000283285_length(amino acids)=127AA_BP=
MKTNHTSPLLGSLVSTFTFSFSCNYLRECSKAPGFWQRVYNVDRCSNKRIRHGHTVETIVVPPSENLNENTVFFFKDGRLICTSYISKKT

--------------------------------------------------------------
>64971_64971_4_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111366389_ENST00000352690_length(transcript)=3121nt_BP=322nt
TGACCACAGTCTGCAGAGGCCAGAGAGAGCAGGAAAGGAAATGGAAAGGAACCTCACCTTCATGCTTGGGGAAAAGGAGAAACCTGTGTT
AATGTGTCTTCCCAACATCCCACTCTCTTCAGCAATCGCTGGAACAGCCATGGGCCATCCCTGCTGAGTCAGGAAAGAAGCTGAGGGAAG
AGTCGGGATTGAAAAGCAGCAGACAAGGCTGGCACTGATCCCAGTTTATCCTTTGAGATTCAGCAGAAGATCCTGATGGAGGAGGAGGAT
ACCAAGAGAGAGGTGCCCAAGGAAGATGGAGTTGGTGATGTGCAACATTTCGGTATTGTGGTCAATAAGCCCAAAGATGGAATGTCCTGG
CCAGTGATTGTAGCAGCTTTACTCTTTTGCTGCATGATATTGTTTGGTCTTGGAGTGAGAAAATGGTGTCAGTACCAAAAAGAAATAATG
GAAAGACCTCCACCTTTCAAGCCACCACCACCTCCCATCAAGTACACTTGCATTCAAGAGCCCAACGAAAGTGATCTGCCTTATCATGAG
ATGGAGACCCTCTAGTCTCGTGAGACTTTGCCCCATGGCAGAACTCTGCTGGAATCCTATTGAGAAGGTAGACATTGTGCTTTATTAATA
TAGTCGCTCTTCAGCCATGCCTTTGCTGCAGCTGAAATGGAAGTCAGAAGTGAGTGACCTGTTTTCCCAGCAACTCACCCTCTTCCATCT
CCAAACGCCTGAAGCTTAACCAAGAGTGAGAGGATATGTCATGTTCACACTCAATGCAATTCGTAGTGGTTTTCTTGCTTATGTAAGAAG
TACATATTAGTCTGCCATCTTTAAAAAAAAATACAGTATTTTCATTTAAATTCTCTGATGGAGGGACAACAATGGTTTCAACTGTATGCC
CATGCCTGATCCTCTTATTTGAACATCTATCAACATTGTAAACTCTTTGCCAAAATCCTGGGGCTTTGCTGCATTCCCTAAGATAATTAC
AGGAAAAAGAAAATGTAAAAGTGCTAACAAGGCTGCCAAGTAATGGAGAAGTATGGTTAGTCTTCATATTGAAATTCTGTTGCTTATTTT
CATGGAAGGAAACAGAATACTTTGCACAGGAACCACATTTTCAATCCTCCTTCACTGTCTTCCTACCATGTTCAGCCCAGACTCCTGCCA
CATGGACCAGGATGAAGAGGGATCAAAGAGATAATTAGCCAAAAACCCAGTAGCCTAGAAGATACAAAACTCCACTGGCCTCTAAAATTA
TATTAGCCAAGAGTGGTTTCATTTGAGTGCCTTCGTGTGTATGTCCATCAAACTGGAACCAAACTGTTTTGTAAGTAAACAGGCAGCCTA
AGCCCAACCCTACTTTCTAATTCCAGTTATTCTCTTTTTCATCTGGGGATTTACCTGTTCATTTAATCTGCCTGTTTTGATCTGTTTTGA
AAAAGATAAAGAGCCTCAAATCAGACCAGCACTGATTAATTAACCCTGCTCCTACCAATCTTTTTTAAAGCAGTTGAAGCAGAATGTATA
GGTGTCAGAGAAGAAACCTAGTCAGCCAGACGTGCTCTGTATTCAGCAATAGTTTGTGAATGAATAAATTACTAATCCTCCTTGTCGCTT
GAAACCTTCCCACACTCCCTGCTCCAGGAGGGAAAAACAGATGTTGTTGACAGATAGAGTGATAGGCAAATTCTGTGTGGACTTTAGTCC
CAAAAGGAAACTTTAGTTCACTTGCAGTATGCTTATCCTTGACTGCACATGAGAATGCCTTGTGCAGAGTTATTTGGAGATTATGTCTTT
TTCTTAAACACCATGGCTGTCACACTTCAGTTCAATTAAATCAGAATGTCTGAGGAGTGAGACACAGGCATCAACACTCTCAAATGATTC
ACATGTTCAGCCAAAGTTGAGAACCATCGAGCCTGTGGAAGTTCTTTCTCATGGCTCAGAATCTTAGGTAGGTGCTTAACTCTTGTGGTG
GCCAGCCTCCAAGATGAGCCCCAGTGTTCTTGCCTCCTACTATTCACATCTTTATGTGGTCCCCTCCAATGCTGAATACAGATGATTTGT
GTAACCTGAGGCCAGGATTAAGGGGAGGCAATCAATGCACCTAGGGAAAAAATTTAAGGAGGTATTCACACTCAGGGTCATGCACTTGCA
CAATGTTGAGAATGAGTACCACTCTCACCATTGGTATAGCCAAAAAAGCTTGGAAGTGACCAAGGCTAGGTCACAAAATACACTGTGGCT
TCTTCTTTGATCTCTCTTTGACCATACTGACACTGGGAAAAGCCCATTCCCATGCCATGAAGACACCAAGGCAGCCCTATTGAGAAATCT
ACCTGTCGTGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGATCGAG
ACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGTCGGGCACCTGTAGTCCCAGCTA
CTCAGGAGGCTGAGGCAGGAGAAGGGTGGGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACACTCCAATCTGGG
TGAAAGACCGAGACTCCGCCTCAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAAATCTACCTGTCAAGGAACTAAGGTATTTT
GCTAACAAGCACCAACTTGCCAGCCATGTAAGGGAGCCATCTTGGAAGCAGATCCTCCAGCCTCCAGTCAAGTCTTCAGATAATTGCAAC
TTCAGTTGATCTTTTGACCAAGACCTCAAGAGAGCCAGAACTACCCAGCTAAGCCTTTTACTAAATTTCTGAACTTCTAACACTATTAGA
TAATAAGTGCTTATTGTTTAACACCATTAATTTTGAGTATAATTTGTTACATAGCGACAGATAACTATACAGCTCAACAACTAGAAAAAT
AAACTGTTTACCTGCCTTAATTATTTATCTTTAGTTCCTTATTAGTTCTCAAGAAACAAATGCTAGCTTCATATGTATGGCTGTTGCTTT

>64971_64971_4_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111366389_ENST00000352690_length(amino acids)=127AA_BP=
MKTNHTSPLLGSLVSTFTFSFSCNYLRECSKAPGFWQRVYNVDRCSNKRIRHGHTVETIVVPPSENLNENTVFFFKDGRLICTSYISKKT

--------------------------------------------------------------
>64971_64971_5_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111366390_ENST00000283285_length(transcript)=2990nt_BP=322nt
TGACCACAGTCTGCAGAGGCCAGAGAGAGCAGGAAAGGAAATGGAAAGGAACCTCACCTTCATGCTTGGGGAAAAGGAGAAACCTGTGTT
AATGTGTCTTCCCAACATCCCACTCTCTTCAGCAATCGCTGGAACAGCCATGGGCCATCCCTGCTGAGTCAGGAAAGAAGCTGAGGGAAG
AGTCGGGATTGAAAAGCAGCAGACAAGGCTGGCACTGATCCCAGTTTATCCTTTGAGATTCAGCAGAAGATCCTGATGGAGGAGGAGGAT
ACCAAGAGAGAGGTGCCCAAGGAAGATGGAGTTGGTGATGTGCAACATTTCGGTATTGTGGTCAATAAGCCCAAAGATGGAATGTCCTGG
CCAGTGATTGTAGCAGCTTTACTCTTTTGCTGCATGATATTGTTTGGTCTTGGAGTGAGAAAATGGTGTCAGTACCAAAAAGAAATAATG
GAAAGACCTCCACCTTTCAAGCCACCACCACCTCCCATCAAGTACACTTGCATTCAAGAGCCCAACGAAAGTGATCTGCCTTATCATGAG
ATGGAGACCCTCTAGTCTCGTGAGACTTTGCCCCATGGCAGAACTCTGCTGGAATCCTATTGAGAAGGTAGACATTGTGCTTTATTAATA
TAGTCGCTCTTCAGCCATGCCTTTGCTGCAGCTGAAATGGAAGTCAGAAGTGAGTGACCTGTTTTCCCAGCAACTCACCCTCTTCCATCT
CCAAACGCCTGAAGCTTAACCAAGAGTGAGAGGATATGTCATGTTCACACTCAATGCAATTCGTAGTGGTTTTCTTGCTTATGTAAGAAG
TACATATTAGTCTGCCATCTTTAAAAAAAAATACAGTATTTTCATTTAAATTCTCTGATGGAGGGACAACAATGGTTTCAACTGTATGCC
CATGCCTGATCCTCTTATTTGAACATCTATCAACATTGTAAACTCTTTGCCAAAATCCTGGGGCTTTGCTGCATTCCCTAAGATAATTAC
AGGAAAAAGAAAATGTAAAAGTGCTAACAAGGCTGCCAAGTAATGGAGAAGTATGGTTAGTCTTCATATTGAAATTCTGTTGCTTATTTT
CATGGAAGGAAACAGAATACTTTGCACAGGAACCACATTTTCAATCCTCCTTCACTGTCTTCCTACCATGTTCAGCCCAGACTCCTGCCA
CATGGACCAGGATGAAGAGGGATCAAAGAGATAATTAGCCAAAAACCCAGTAGCCTAGAAGATACAAAACTCCACTGGCCTCTAAAATTA
TATTAGCCAAGAGTGGTTTCATTTGAGTGCCTTCGTGTGTATGTCCATCAAACTGGAACCAAACTGTTTTGTAAGTAAACAGGCAGCCTA
AGCCCAACCCTACTTTCTAATTCCAGTTATTCTCTTTTTCATCTGGGGATTTACCTGTTCATTTAATCTGCCTGTTTTGATCTGTTTTGA
AAAAGATAAAGAGCCTCAAATCAGACCAGCACTGATTAATTAACCCTGCTCCTACCAATCTTTTTTAAAGCAGTTGAAGCAGAATGTATA
GGTGTCAGAGAAGAAACCTAGTCAGCCAGACGTGCTCTGTATTCAGCAATAGTTTGTGAATGAATAAATTACTAATCCTCCTTGTCGCTT
GAAACCTTCCCACACTCCCTGCTCCAGGAGGGAAAAACAGATGTTGTTGACAGATAGAGTGATAGGCAAATTCTGTGTGGACTTTAGTCC
CAAAAGGAAACTTTAGTTCACTTGCAGTATGCTTATCCTTGACTGCACATGAGAATGCCTTGTGCAGAGTTATTTGGAGATTATGTCTTT
TTCTTAAACACCATGGCTGTCACACTTCAGTTCAATTAAATCAGAATGTCTGAGGAGTGAGACACAGGCATCAACACTCTCAAATGATTC
ACATGTTCAGCCAAAGTTGAGAACCATCGAGCCTGTGGAAGTTCTTTCTCATGGCTCAGAATCTTAGGTAGGTGCTTAACTCTTGTGGTG
GCCAGCCTCCAAGATGAGCCCCAGTGTTCTTGCCTCCTACTATTCACATCTTTATGTGGTCCCCTCCAATGCTGAATACAGATGATTTGT
GTAACCTGAGGCCAGGATTAAGGGGAGGCAATCAATGCACCTAGGGAAAAAATTTAAGGAGGTATTCACACTCAGGGTCATGCACTTGCA
CAATGTTGAGAATGAGTACCACTCTCACCATTGGTATAGCCAAAAAAGCTTGGAAGTGACCAAGGCTAGGTCACAAAATACACTGTGGCT
TCTTCTTTGATCTCTCTTTGACCATACTGACACTGGGAAAAGCCCATTCCCATGCCATGAAGACACCAAGGCAGCCCTATTGAGAAATCT
ACCTGTCGTGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGATCGAG
ACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGTCGGGCACCTGTAGTCCCAGCTA
CTCAGGAGGCTGAGGCAGGAGAAGGGTGGGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACACTCCAATCTGGG
TGAAAGACCGAGACTCCGCCTCAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAAATCTACCTGTCAAGGAACTAAGGTATTTT
GCTAACAAGCACCAACTTGCCAGCCATGTAAGGGAGCCATCTTGGAAGCAGATCCTCCAGCCTCCAGTCAAGTCTTCAGATAATTGCAAC
TTCAGTTGATCTTTTGACCAAGACCTCAAGAGAGCCAGAACTACCCAGCTAAGCCTTTTACTAAATTTCTGAACTTCTAACACTATTAGA
TAATAAGTGCTTATTGTTTAACACCATTAATTTTGAGTATAATTTGTTACATAGCGACAGATAACTATACAGCTCAACAACTAGAAAAAT

>64971_64971_5_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111366390_ENST00000283285_length(amino acids)=127AA_BP=
MKTNHTSPLLGSLVSTFTFSFSCNYLRECSKAPGFWQRVYNVDRCSNKRIRHGHTVETIVVPPSENLNENTVFFFKDGRLICTSYISKKT

--------------------------------------------------------------
>64971_64971_6_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111366390_ENST00000352690_length(transcript)=3121nt_BP=322nt
TGACCACAGTCTGCAGAGGCCAGAGAGAGCAGGAAAGGAAATGGAAAGGAACCTCACCTTCATGCTTGGGGAAAAGGAGAAACCTGTGTT
AATGTGTCTTCCCAACATCCCACTCTCTTCAGCAATCGCTGGAACAGCCATGGGCCATCCCTGCTGAGTCAGGAAAGAAGCTGAGGGAAG
AGTCGGGATTGAAAAGCAGCAGACAAGGCTGGCACTGATCCCAGTTTATCCTTTGAGATTCAGCAGAAGATCCTGATGGAGGAGGAGGAT
ACCAAGAGAGAGGTGCCCAAGGAAGATGGAGTTGGTGATGTGCAACATTTCGGTATTGTGGTCAATAAGCCCAAAGATGGAATGTCCTGG
CCAGTGATTGTAGCAGCTTTACTCTTTTGCTGCATGATATTGTTTGGTCTTGGAGTGAGAAAATGGTGTCAGTACCAAAAAGAAATAATG
GAAAGACCTCCACCTTTCAAGCCACCACCACCTCCCATCAAGTACACTTGCATTCAAGAGCCCAACGAAAGTGATCTGCCTTATCATGAG
ATGGAGACCCTCTAGTCTCGTGAGACTTTGCCCCATGGCAGAACTCTGCTGGAATCCTATTGAGAAGGTAGACATTGTGCTTTATTAATA
TAGTCGCTCTTCAGCCATGCCTTTGCTGCAGCTGAAATGGAAGTCAGAAGTGAGTGACCTGTTTTCCCAGCAACTCACCCTCTTCCATCT
CCAAACGCCTGAAGCTTAACCAAGAGTGAGAGGATATGTCATGTTCACACTCAATGCAATTCGTAGTGGTTTTCTTGCTTATGTAAGAAG
TACATATTAGTCTGCCATCTTTAAAAAAAAATACAGTATTTTCATTTAAATTCTCTGATGGAGGGACAACAATGGTTTCAACTGTATGCC
CATGCCTGATCCTCTTATTTGAACATCTATCAACATTGTAAACTCTTTGCCAAAATCCTGGGGCTTTGCTGCATTCCCTAAGATAATTAC
AGGAAAAAGAAAATGTAAAAGTGCTAACAAGGCTGCCAAGTAATGGAGAAGTATGGTTAGTCTTCATATTGAAATTCTGTTGCTTATTTT
CATGGAAGGAAACAGAATACTTTGCACAGGAACCACATTTTCAATCCTCCTTCACTGTCTTCCTACCATGTTCAGCCCAGACTCCTGCCA
CATGGACCAGGATGAAGAGGGATCAAAGAGATAATTAGCCAAAAACCCAGTAGCCTAGAAGATACAAAACTCCACTGGCCTCTAAAATTA
TATTAGCCAAGAGTGGTTTCATTTGAGTGCCTTCGTGTGTATGTCCATCAAACTGGAACCAAACTGTTTTGTAAGTAAACAGGCAGCCTA
AGCCCAACCCTACTTTCTAATTCCAGTTATTCTCTTTTTCATCTGGGGATTTACCTGTTCATTTAATCTGCCTGTTTTGATCTGTTTTGA
AAAAGATAAAGAGCCTCAAATCAGACCAGCACTGATTAATTAACCCTGCTCCTACCAATCTTTTTTAAAGCAGTTGAAGCAGAATGTATA
GGTGTCAGAGAAGAAACCTAGTCAGCCAGACGTGCTCTGTATTCAGCAATAGTTTGTGAATGAATAAATTACTAATCCTCCTTGTCGCTT
GAAACCTTCCCACACTCCCTGCTCCAGGAGGGAAAAACAGATGTTGTTGACAGATAGAGTGATAGGCAAATTCTGTGTGGACTTTAGTCC
CAAAAGGAAACTTTAGTTCACTTGCAGTATGCTTATCCTTGACTGCACATGAGAATGCCTTGTGCAGAGTTATTTGGAGATTATGTCTTT
TTCTTAAACACCATGGCTGTCACACTTCAGTTCAATTAAATCAGAATGTCTGAGGAGTGAGACACAGGCATCAACACTCTCAAATGATTC
ACATGTTCAGCCAAAGTTGAGAACCATCGAGCCTGTGGAAGTTCTTTCTCATGGCTCAGAATCTTAGGTAGGTGCTTAACTCTTGTGGTG
GCCAGCCTCCAAGATGAGCCCCAGTGTTCTTGCCTCCTACTATTCACATCTTTATGTGGTCCCCTCCAATGCTGAATACAGATGATTTGT
GTAACCTGAGGCCAGGATTAAGGGGAGGCAATCAATGCACCTAGGGAAAAAATTTAAGGAGGTATTCACACTCAGGGTCATGCACTTGCA
CAATGTTGAGAATGAGTACCACTCTCACCATTGGTATAGCCAAAAAAGCTTGGAAGTGACCAAGGCTAGGTCACAAAATACACTGTGGCT
TCTTCTTTGATCTCTCTTTGACCATACTGACACTGGGAAAAGCCCATTCCCATGCCATGAAGACACCAAGGCAGCCCTATTGAGAAATCT
ACCTGTCGTGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGATCGAG
ACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGTCGGGCACCTGTAGTCCCAGCTA
CTCAGGAGGCTGAGGCAGGAGAAGGGTGGGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGTGCCACTGCACACTCCAATCTGGG
TGAAAGACCGAGACTCCGCCTCAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAAATCTACCTGTCAAGGAACTAAGGTATTTT
GCTAACAAGCACCAACTTGCCAGCCATGTAAGGGAGCCATCTTGGAAGCAGATCCTCCAGCCTCCAGTCAAGTCTTCAGATAATTGCAAC
TTCAGTTGATCTTTTGACCAAGACCTCAAGAGAGCCAGAACTACCCAGCTAAGCCTTTTACTAAATTTCTGAACTTCTAACACTATTAGA
TAATAAGTGCTTATTGTTTAACACCATTAATTTTGAGTATAATTTGTTACATAGCGACAGATAACTATACAGCTCAACAACTAGAAAAAT
AAACTGTTTACCTGCCTTAATTATTTATCTTTAGTTCCTTATTAGTTCTCAAGAAACAAATGCTAGCTTCATATGTATGGCTGTTGCTTT

>64971_64971_6_PHLDB2-CD96_PHLDB2_chr3_111564782_ENST00000393923_CD96_chr3_111366390_ENST00000352690_length(amino acids)=127AA_BP=
MKTNHTSPLLGSLVSTFTFSFSCNYLRECSKAPGFWQRVYNVDRCSNKRIRHGHTVETIVVPPSENLNENTVFFFKDGRLICTSYISKKT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PHLDB2-CD96

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PHLDB2-CD96

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PHLDB2-CD96

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source