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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PHYHD1-LRRC8A (FusionGDB2 ID:65029)

Fusion Gene Summary for PHYHD1-LRRC8A

check button Fusion gene summary
Fusion gene informationFusion gene name: PHYHD1-LRRC8A
Fusion gene ID: 65029
HgeneTgene
Gene symbol

PHYHD1

LRRC8A

Gene ID

254295

56262

Gene namephytanoyl-CoA dioxygenase domain containing 1leucine rich repeat containing 8 VRAC subunit A
Synonyms-AGM5|LRRC8|SWELL1
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionphytanoyl-CoA dioxygenase domain-containing protein 1volume-regulated anion channel subunit LRRC8Aleucine rich repeat containing 8 family member Aleucine-rich repeat-containing protein 8Aswelling protein 1
Modification date2020031320200329
UniProtAcc.

Q8IWT6

Ensembl transtripts involved in fusion geneENST00000308941, ENST00000353176, 
ENST00000372592, ENST00000421063, 
ENST00000487504, 		ENST00000492784, 
ENST00000259324, ENST00000372599, 
ENST00000372600, 
Fusion gene scores* DoF score2 X 3 X 2=124 X 3 X 4=48
# samples 35
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PHYHD1 [Title/Abstract] AND LRRC8A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPHYHD1(131689475)-LRRC8A(131678375), # samples:2
Anticipated loss of major functional domain due to fusion event.PHYHD1-LRRC8A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PHYHD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC8A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0XU-01APHYHD1chr9

131689475

-LRRC8Achr9

131678375

+
ChimerDB4BRCATCGA-AN-A0XU-01APHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
ChiTaRS5.0N/AAI879160PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+


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Fusion Gene ORF analysis for PHYHD1-LRRC8A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000308941ENST00000492784PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
5CDS-3UTRENST00000353176ENST00000492784PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
5CDS-3UTRENST00000372592ENST00000492784PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
5CDS-3UTRENST00000421063ENST00000492784PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
5CDS-5UTRENST00000308941ENST00000259324PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000308941ENST00000372599PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000308941ENST00000372600PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000353176ENST00000259324PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000353176ENST00000372599PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000353176ENST00000372600PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000372592ENST00000259324PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000372592ENST00000372599PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000372592ENST00000372600PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000421063ENST00000259324PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000421063ENST00000372599PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-5UTRENST00000421063ENST00000372600PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-intronENST00000308941ENST00000492784PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-intronENST00000353176ENST00000492784PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-intronENST00000372592ENST00000492784PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
5CDS-intronENST00000421063ENST00000492784PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
Frame-shiftENST00000308941ENST00000259324PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
Frame-shiftENST00000353176ENST00000259324PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
Frame-shiftENST00000372592ENST00000259324PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
Frame-shiftENST00000421063ENST00000259324PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
In-frameENST00000308941ENST00000372599PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
In-frameENST00000308941ENST00000372600PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
In-frameENST00000353176ENST00000372599PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
In-frameENST00000353176ENST00000372600PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
In-frameENST00000372592ENST00000372599PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
In-frameENST00000372592ENST00000372600PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
In-frameENST00000421063ENST00000372599PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
In-frameENST00000421063ENST00000372600PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
intron-3CDSENST00000487504ENST00000259324PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
intron-3CDSENST00000487504ENST00000372599PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
intron-3CDSENST00000487504ENST00000372600PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
intron-3UTRENST00000487504ENST00000492784PHYHD1chr9

131689475

+LRRC8Achr9

131678375

+
intron-5UTRENST00000487504ENST00000259324PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
intron-5UTRENST00000487504ENST00000372599PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
intron-5UTRENST00000487504ENST00000372600PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+
intron-intronENST00000487504ENST00000492784PHYHD1chr9

131689477

+LRRC8Achr9

131669434

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PHYHD1-LRRC8A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PHYHD1chr9131689475+LRRC8Achr9131678374+4.95E-121
PHYHD1chr9131689475+LRRC8Achr9131669435+2.93E-101
PHYHD1chr9131689475+LRRC8Achr9131678374+4.95E-121
PHYHD1chr9131689475+LRRC8Achr9131669435+2.93E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PHYHD1-LRRC8A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131689475/chr9:131678375)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRRC8A

Q8IWT6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:29769723, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:30095067, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:33171122). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (PubMed:33171122). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:31270356, PubMed:33139539). {ECO:0000250|UniProtKB:Q80WG5, ECO:0000269|PubMed:14660746, ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:29371604, ECO:0000269|PubMed:29769723, ECO:0000269|PubMed:30095067, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:33139539, ECO:0000269|PubMed:33171122}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424732_753719811.0RepeatLRR 15
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424754_776719811.0RepeatLRR 16
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424778_801719811.0RepeatLRR 17
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913732_753719811.0RepeatLRR 15
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913754_776719811.0RepeatLRR 16
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913778_801719811.0RepeatLRR 17
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024732_753719811.0RepeatLRR 15
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024754_776719811.0RepeatLRR 16
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024778_801719811.0RepeatLRR 17

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHYHD1chr9:131689475chr9:131678375ENST00000308941+412156_15864298.0RegionAlpha-ketoglutarate binding
HgenePHYHD1chr9:131689475chr9:131678375ENST00000353176+412156_15864271.0RegionAlpha-ketoglutarate binding
HgenePHYHD1chr9:131689475chr9:131678375ENST00000372592+413156_15864292.0RegionAlpha-ketoglutarate binding
HgenePHYHD1chr9:131689475chr9:131678375ENST00000421063+210156_15864271.0RegionAlpha-ketoglutarate binding
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424399_422719811.0RepeatLRR 1
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424423_445719811.0RepeatLRR 2
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424447_468719811.0RepeatLRR 3
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424469_492719811.0RepeatLRR 4
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424493_515719811.0RepeatLRR 5
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424518_542719811.0RepeatLRR 6
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424543_565719811.0RepeatLRR 7
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424567_589719811.0RepeatLRR 8
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424590_613719811.0RepeatLRR 9
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424615_637719811.0RepeatLRR 10
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424639_661719811.0RepeatLRR 11
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424662_684719811.0RepeatLRR 12
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424686_707719811.0RepeatLRR 13
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424708_730719811.0RepeatLRR 14
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913399_422719811.0RepeatLRR 1
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913423_445719811.0RepeatLRR 2
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913447_468719811.0RepeatLRR 3
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913469_492719811.0RepeatLRR 4
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913493_515719811.0RepeatLRR 5
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913518_542719811.0RepeatLRR 6
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913543_565719811.0RepeatLRR 7
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913567_589719811.0RepeatLRR 8
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913590_613719811.0RepeatLRR 9
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913615_637719811.0RepeatLRR 10
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913639_661719811.0RepeatLRR 11
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913662_684719811.0RepeatLRR 12
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913686_707719811.0RepeatLRR 13
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913708_730719811.0RepeatLRR 14
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024399_422719811.0RepeatLRR 1
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024423_445719811.0RepeatLRR 2
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024447_468719811.0RepeatLRR 3
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024469_492719811.0RepeatLRR 4
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024493_515719811.0RepeatLRR 5
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024518_542719811.0RepeatLRR 6
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024543_565719811.0RepeatLRR 7
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024567_589719811.0RepeatLRR 8
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024590_613719811.0RepeatLRR 9
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024615_637719811.0RepeatLRR 10
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024639_661719811.0RepeatLRR 11
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024662_684719811.0RepeatLRR 12
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024686_707719811.0RepeatLRR 13
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024708_730719811.0RepeatLRR 14
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424145_258719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST00000259324241_22719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424287_314719811.0Topological domainExtracellular
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424346_810719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST000002593242449_119719811.0Topological domainExtracellular
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913145_258719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST00000372599131_22719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913287_314719811.0Topological domainExtracellular
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913346_810719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST000003725991349_119719811.0Topological domainExtracellular
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024145_258719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST00000372600241_22719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024287_314719811.0Topological domainExtracellular
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024346_810719811.0Topological domainCytoplasmic
TgeneLRRC8Achr9:131689475chr9:131678375ENST000003726002449_119719811.0Topological domainExtracellular
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424120_144719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST000002593242423_48719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424259_286719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000025932424315_345719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913120_144719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST000003725991323_48719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913259_286719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037259913315_345719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024120_144719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST000003726002423_48719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024259_286719811.0TransmembraneHelical
TgeneLRRC8Achr9:131689475chr9:131678375ENST0000037260024315_345719811.0TransmembraneHelical


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Fusion Gene Sequence for PHYHD1-LRRC8A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PHYHD1-LRRC8A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PHYHD1-LRRC8A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PHYHD1-LRRC8A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource