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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PI4KA-FAM19A5 (FusionGDB2 ID:65067)

Fusion Gene Summary for PI4KA-FAM19A5

Fusion gene summary

Fusion gene information	Fusion gene name: PI4KA-FAM19A5
	Fusion gene ID: 65067
		Hgene	Tgene
	Gene symbol	PI4KA	FAM19A5
	Gene ID	5297	25817
	Gene name	phosphatidylinositol 4-kinase alpha	TAFA chemokine like family member 5
	Synonyms	PI4K-ALPHA\|PIK4CA\|PMGYCHA\|pi4K230	FAM19A5\|QLLK5208\|TAFA-5\|UNQ5208
	Cytomap	22q11.21	22q13.32
	Type of gene	protein-coding	protein-coding
	Description	phosphatidylinositol 4-kinase alphaPI4-kinase alphaphosphatidylinositol 4-kinase 230phosphatidylinositol 4-kinase III alphaphosphatidylinositol 4-kinase IIII+/-phosphatidylinositol 4-kinase, catalytic, alphaphosphatidylinositol 4-kinase, type III, a	chemokine-like protein TAFA-5TAFA protein 5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5family with sequence similarity 19 member A5, C-C motif chemokine likeprotein FAM19A5
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000255882, ENST00000572273, ENST00000466162, ENST00000414196,	ENST00000406880, ENST00000473898, ENST00000358295, ENST00000402357,
Fusion gene scores	* DoF score	20 X 14 X 12=3360	10 X 7 X 6=420
	# samples	21	10
	** MAII score	log2(21/3360*10)=-4 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/420*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PI4KA [Title/Abstract] AND FAM19A5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PI4KA(21147481)-FAM19A5(49103529), # samples:3
Anticipated loss of major functional domain due to fusion event.	PI4KA-FAM19A5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PI4KA-FAM19A5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PI4KA-FAM19A5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PI4KA	GO:0016310	phosphorylation	25327288

Fusion gene breakpoints across PI4KA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM19A5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-C8-A12W-01A	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+

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Fusion Gene ORF analysis for PI4KA-FAM19A5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000255882	ENST00000406880	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
5CDS-3UTR	ENST00000255882	ENST00000473898	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
5CDS-3UTR	ENST00000572273	ENST00000406880	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
5CDS-3UTR	ENST00000572273	ENST00000473898	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
5UTR-3CDS	ENST00000466162	ENST00000358295	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
5UTR-3CDS	ENST00000466162	ENST00000402357	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
5UTR-3UTR	ENST00000466162	ENST00000406880	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
5UTR-3UTR	ENST00000466162	ENST00000473898	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
Frame-shift	ENST00000255882	ENST00000358295	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
Frame-shift	ENST00000255882	ENST00000402357	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
In-frame	ENST00000572273	ENST00000358295	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
In-frame	ENST00000572273	ENST00000402357	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
intron-3CDS	ENST00000414196	ENST00000358295	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
intron-3CDS	ENST00000414196	ENST00000402357	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
intron-3UTR	ENST00000414196	ENST00000406880	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+
intron-3UTR	ENST00000414196	ENST00000473898	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000572273

PI4KA

chr22

21147481

ENST00000402357

FAM19A5

chr22

49103529

3498

2385

2456

799

ENST00000572273

PI4KA

chr22

21147481

ENST00000358295

FAM19A5

chr22

49103529

4607

2385

2456

799

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000572273	ENST00000402357	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+	0.005821195	0.9941788
ENST00000572273	ENST00000358295	PI4KA	chr22	21147481	-	FAM19A5	chr22	49103529	+	0.00291558	0.99708444

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Fusion Genomic Features for PI4KA-FAM19A5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PI4KA	chr22	21147480	-	FAM19A5	chr22	49103528	+	1.79E-05	0.9999821
PI4KA	chr22	21147480	-	FAM19A5	chr22	49103528	+	1.79E-05	0.9999821

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PI4KA-FAM19A5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:21147481/chr22:49103529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PI4KA

chr22:21147481

chr22:49103529

ENST00000414196

1530_1718

855.0

Domain

PIK helical

Hgene

PI4KA

chr22:21147481

chr22:49103529

ENST00000414196

1846_2079

855.0

Domain

PI3K/PI4K

Hgene

PI4KA

chr22:21147481

chr22:49103529

ENST00000572273

1530_1718

718

2045.0

Domain

PIK helical

Hgene

PI4KA

chr22:21147481

chr22:49103529

ENST00000572273

1846_2079

718

2045.0

Domain

PI3K/PI4K

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Fusion Gene Sequence for PI4KA-FAM19A5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>65067_65067_1_PI4KA-FAM19A5_PI4KA_chr22_21147481_ENST00000572273_FAM19A5_chr22_49103529_ENST00000358295_length(transcript)=4607nt_BP=2385nt
GGGCGCTCGCGGGCCAGGAGCGGGGAGCCGGCGGGCAGCGCCGCGGCTCGTGAGGTGATGGCGGCGGCCCCGGCCCGGGGAGGCGGAGGC
GGAGGCGGAGGCGGCGGCGGCTGCTCCGGCTCCGGCTCCAGCGCCTCGCGGGGCTTCTATTTCAACACGGTCCTGTCACTGGCCCGCTCC
CTGGCGGTGCAGAGACCAGCATCCTTGGAGAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGAT
GAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTT
CGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTC
AGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTG
CATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCG
CGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAA
GAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTG
AAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTT
CACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCT
CCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAG
GAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGAC
CCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGAT
TTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTC
AAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAG
CTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGC
CTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTC
TACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTC
ATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTG
ACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTG
ATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTA
CAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATC
TATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGC
TATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATG
AACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCT
AGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCAAGAATCATCAAGACCAAGCAGTGGTGTGACATGCTTCCGTGTC
TGGAGGGGGAAGGCTGCGACTTGTTAATCAACCGGTCAGGCTGGACGTGCACGCAGCCCGGCGGGAGGATAAAGACCACCACGGTCTCCT
GACAAACACAGCCCCTGAGGGGCCCCGGGAGTGGCCTTGGCTCCCTGGAGAGCCCACGTCTCAGCCACAGTTCTCCACTCGCCTCGGACT
TCACCCGTTCTCTGCCGCCCGCCCACTCCGTTTCCCTGTGGTCCGTGAAGGACGGCCTCAGGCCTTGGCATCCTGAGCTTCGGTCTGTCC
AGCCGACCCGAGGAGGCCGGACTCAGACACATAGGCGGGGGGCGGCACCTGGCATCAGCAATACGCAGTCTGTGGGAGCCCGGCCGCGCC
CAGCCCCCGCCGACCGTGGCGTTGGCCCTGCTGTCCTCAGAGGAGGAGGAGGAGGAGGCAGCTCCGGCAGCCACAGAAGGCTGCAGCCCA
GCCCGCCTGAGACACGACGCCTGCCCCAGGGGACTGTCAGGCACAGAAGCGGCCTCCTCCCGTGCCCCAGACTGTCCGAATTGCTTTTAT
TTTCTTATACTTTCAGTATACTCCATAGACCAAAGAGCAAAATCTATCTGAACCTGGACGCACCCTCACTGTCAGGGTCCCTGGGGTCGC
TTGTGCGGGCGGGAGGGCAATGGTGGCAGAGACATGCTGGTGGCCCCGGCGGAGCGGAGAGGGCGGCCGTGGTGGAGGCCTCCACCCCAG
GAGCACCCCGCGCACCCTCGGAGGACGGGCTTCGGCTGCGCGGAGGCCGTGGCACACCTGCGGGAGGCAGCGACGGCCCCCACGCAGACG
CCGGGAACGCAGGCCGCTTTATTCCTCTGTACTTAGATCAACTTGACCGTACTAAAATCCCTTTCTGTTTTAACCAGTTAAACATGCCTC
TTCTACAGCTCCATTTTTGATAGTTGGATAATCCAGTATCTGCCAAGAGCATGTTGGGTCTCCCGTGACTGCTGCCTCATCGATACCCCA
TTTAGCTCCAGAAAGCAAAGAAAACTCGAGTAACACTTGTTTGAAAGAGATCATTAAATGTATTTTGCAAAGCCTAAAGTTATATATTTA
ACAGTTTTTATATGTTGTATATTTGTAGAAAATCCTATTTAACAATTAACGTGGCAGTCCCGGCCGTCCTGAGAGTCGGGCCGAGCCCCG
TGTGTTTCTGAAGACTCTGGGGGTGGGACACGGCGGGGAGGTGGTGCCCCGCGGACCCCGGGGTGCCAGGCACGGAAGGCGGGACTCTGG
GAGAAGCGTGCGGAGGACCGTGGCGTCGGCGTCCCGGATGTGTCGGTCGTGCCCGGGGAGGCCGGGTTCCCCTCGCTGCGGGCCAGGCTT
GGCTCCTGATTCCCTCTCTGGTCCCTGTATTGGTCAACACTTGAGCGTACAATATCTTGAACATGCTTCTTCCAATGGGTTTTGTTTCCC
ATTTCCTGCCCCTTTCGCCACTCACGGACCTTGAGGCCAGTTGACGGCCCTTCTCCCCACGCCTGTGTCCCCGCGTTCTGAGAAGTCCTC
TGTCTTCGTGTCACTAGGTCCAGAAAGTCGCGCCGGGCAGAGGCGCAGGCGGGGCCGGCAGGGCCGAGGAATAAGCGACAATTCTGGTTT
TTCTCCCCTGGCCGTCGTTCGCCAGCCTCCTTCATTTTCCTGAGTTCCCGCTGAAGTATATACTACCTATGAGTCCAATTAACATGAGTA
TTATGCTAGTTCTATCCTACTAAAAAAAACGTAAAAAAATAACTATATAGAAGCTGTTCCAGCAACCATAGACTGAAGATACGAAAGAAA
ATCCATTTATTTAAGACCTGTTCCGGTATCCATGAGGACATAATTTACCTTTCAGTCACCACAAATTTATAGGCATTTGTATCCTGGACT
AAAAGAAGGGGCTGAGGTTGGGTTTGTCATCACAGAGGGGGTGGGCCTGGAAAGGGTCCTTCCCAAGCTGCCCCGGCTCCGGCGGCCCGG
GCCGGCAGCCTCTGCCAGCCAGCGTCCTCACGGCCTCCCCCTCGCCTGTTTCTTTTGAAAGCAAGTGTAGACACCTTCGAGGGCAGAGAT
CGGGAGATTTAAGATGTTACAGCATATTTTTTTTTCTTGTTTTACAGTATTCAATTTTGTGTTGATTCAGCTAAATTATGAAAAATAAAG

>65067_65067_1_PI4KA-FAM19A5_PI4KA_chr22_21147481_ENST00000572273_FAM19A5_chr22_49103529_ENST00000358295_length(amino acids)=799AA_BP=776
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDL
QHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGM
PPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVK
DEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDT
PKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI

--------------------------------------------------------------
>65067_65067_2_PI4KA-FAM19A5_PI4KA_chr22_21147481_ENST00000572273_FAM19A5_chr22_49103529_ENST00000402357_length(transcript)=3498nt_BP=2385nt
GGGCGCTCGCGGGCCAGGAGCGGGGAGCCGGCGGGCAGCGCCGCGGCTCGTGAGGTGATGGCGGCGGCCCCGGCCCGGGGAGGCGGAGGC
GGAGGCGGAGGCGGCGGCGGCTGCTCCGGCTCCGGCTCCAGCGCCTCGCGGGGCTTCTATTTCAACACGGTCCTGTCACTGGCCCGCTCC
CTGGCGGTGCAGAGACCAGCATCCTTGGAGAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGAT
GAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTT
CGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTC
AGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTG
CATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCG
CGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAA
GAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTG
AAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTT
CACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCT
CCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAG
GAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGAC
CCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGAT
TTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTC
AAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAG
CTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGC
CTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTC
TACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTC
ATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTG
ACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTG
ATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTA
CAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATC
TATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGC
TATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATG
AACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCT
AGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCAAGAATCATCAAGACCAAGCAGTGGTGTGACATGCTTCCGTGTC
TGGAGGGGGAAGGCTGCGACTTGTTAATCAACCGGTCAGGCTGGACGTGCACGCAGCCCGGCGGGAGGATAAAGACCACCACGGTCTCCT
GACAAACACAGCCCCTGAGGGGCCCCGGGAGTGGCCTTGGCTCCCTGGAGAGCCCACGTCTCAGCCACAGTTCTCCACTCGCCTCGGACT
TCACCCGTTCTCTGCCGCCCGCCCACTCCGTTTCCCTGTGGTCCGTGAAGGACGGCCTCAGGCCTTGGCATCCTGAGCTTCGGTCTGTCC
AGCCGACCCGAGGAGGCCGGACTCAGACACATAGGCGGGGGGCGGCACCTGGCATCAGCAATACGCAGTCTGTGGGAGCCCGGCCGCGCC
CAGCCCCCGCCGACCGTGGCGTTGGCCCTGCTGTCCTCAGAGGAGGAGGAGGAGGAGGCAGCTCCGGCAGCCACAGAAGGCTGCAGCCCA
GCCCGCCTGAGACACGACGCCTGCCCCAGGGGACTGTCAGGCACAGAAGCGGCCTCCTCCCGTGCCCCAGACTGTCCGAATTGCTTTTAT
TTTCTTATACTTTCAGTATACTCCATAGACCAAAGAGCAAAATCTATCTGAACCTGGACGCACCCTCACTGTCAGGGTCCCTGGGGTCGC
TTGTGCGGGCGGGAGGGCAATGGTGGCAGAGACATGCTGGTGGCCCCGGCGGAGCGGAGAGGGCGGCCGTGGTGGAGGCCTCCACCCCAG
GAGCACCCCGCGCACCCTCGGAGGACGGGCTTCGGCTGCGCGGAGGCCGTGGCACACCTGCGGGAGGCAGCGACGGCCCCCACGCAGACG
CCGGGAACGCAGGCCGCTTTATTCCTCTGTACTTAGATCAACTTGACCGTACTAAAATCCCTTTCTGTTTTAACCAGTTAAACATGCCTC
TTCTACAGCTCCATTTTTGATAGTTGGATAATCCAGTATCTGCCAAGAGCATGTTGGGTCTCCCGTGACTGCTGCCTCATCGATACCCCA

>65067_65067_2_PI4KA-FAM19A5_PI4KA_chr22_21147481_ENST00000572273_FAM19A5_chr22_49103529_ENST00000402357_length(amino acids)=799AA_BP=776
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDL
QHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGM
PPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVK
DEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDT
PKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI

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Fusion Gene PPI Analysis for PI4KA-FAM19A5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PI4KA-FAM19A5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PI4KA-FAM19A5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source