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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIAS1-MAP2K5 (FusionGDB2 ID:65103)

Fusion Gene Summary for PIAS1-MAP2K5

check button Fusion gene summary
Fusion gene informationFusion gene name: PIAS1-MAP2K5
Fusion gene ID: 65103
HgeneTgene
Gene symbol

PIAS1

MAP2K5

Gene ID

8554

5607

Gene nameprotein inhibitor of activated STAT 1mitogen-activated protein kinase kinase 5
SynonymsDDXBP1|GBP|GU/RH-II|ZMIZ3HsT17454|MAPKK5|MEK5|PRKMK5
Cytomap

15q23

15q23

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase PIAS1AR interacting proteinDEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1DEAD/H box-binding protein 1E3 SUMO-protein transferase PIAS1RNA helicase II-binding proteingu-binding proteinprotein inhibitor of activated STAT prdual specificity mitogen-activated protein kinase kinase 5MAP kinase kinase 5MAP kinase kinase MEK5bMAPK/ERK kinase 5MAPKK 5MEK 5
Modification date2020031320200327
UniProtAcc.

Q13163

Ensembl transtripts involved in fusion geneENST00000249636, ENST00000545237, 
ENST00000567417, 		ENST00000340972, 
ENST00000354498, ENST00000395476, 
ENST00000560591, ENST00000178640, 
Fusion gene scores* DoF score13 X 12 X 7=109213 X 18 X 12=2808
# samples 1519
** MAII scorelog2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2808*10)=-3.88547161197361
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIAS1 [Title/Abstract] AND MAP2K5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP2K5(67950952)-PIAS1(68434628), # samples:1
PIAS1(68379088)-MAP2K5(67984817), # samples:1
Anticipated loss of major functional domain due to fusion event.MAP2K5-PIAS1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MAP2K5-PIAS1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
MAP2K5-PIAS1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIAS1

GO:0016925

protein sumoylation

18579533

HgenePIAS1

GO:0033235

positive regulation of protein sumoylation

17696781|21965678


check buttonFusion gene breakpoints across PIAS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP2K5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-RA-A741-01APIAS1chr15

68379088

-MAP2K5chr15

67984817

+


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Fusion Gene ORF analysis for PIAS1-MAP2K5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000249636ENST00000340972PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
5CDS-intronENST00000249636ENST00000354498PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
5CDS-intronENST00000249636ENST00000395476PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
5CDS-intronENST00000249636ENST00000560591PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
5CDS-intronENST00000545237ENST00000340972PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
5CDS-intronENST00000545237ENST00000354498PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
5CDS-intronENST00000545237ENST00000395476PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
5CDS-intronENST00000545237ENST00000560591PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
In-frameENST00000249636ENST00000178640PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
In-frameENST00000545237ENST00000178640PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
intron-3CDSENST00000567417ENST00000178640PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
intron-intronENST00000567417ENST00000340972PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
intron-intronENST00000567417ENST00000354498PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
intron-intronENST00000567417ENST00000395476PIAS1chr15

68379088

-MAP2K5chr15

67984817

+
intron-intronENST00000567417ENST00000560591PIAS1chr15

68379088

-MAP2K5chr15

67984817

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000249636PIAS1chr1568379088-ENST00000178640MAP2K5chr1567984817+14906171481116322
ENST00000545237PIAS1chr1568379088-ENST00000178640MAP2K5chr1567984817+208912167411715324

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000249636ENST00000178640PIAS1chr1568379088-MAP2K5chr1567984817+0.0111803130.98881966
ENST00000545237ENST00000178640PIAS1chr1568379088-MAP2K5chr1567984817+0.0090683590.99093163

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Fusion Genomic Features for PIAS1-MAP2K5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PIAS1-MAP2K5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:67950952/chr15:68434628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP2K5

Q13163

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-21411_45156652.0DomainSAP
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-21419_23156652.0MotifNote=LXXLL motif
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-21456_64156652.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214577_634156652.0Compositional biasNote=Ser-rich
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214124_288156652.0DomainPINIT
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214368_380156652.0MotifNuclear localization signal
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214462_473156652.0RegionSUMO1-binding
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214520_615156652.0RegionNote=4 X 4 AA repeats of N-T-S-L
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214520_523156652.0RepeatNote=1
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214557_560156652.0RepeatNote=2
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214598_601156652.0RepeatNote=3%3B approximate
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214612_615156652.0RepeatNote=4%3B approximate
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636-214320_397156652.0Zinc fingerSP-RING-type
TgeneMAP2K5chr15:68379088chr15:67984817ENST000001786401222166_409282449.0DomainProtein kinase
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640122218_109282449.0DomainPB1
TgeneMAP2K5chr15:68379088chr15:67984817ENST000003544981222166_409246413.0DomainProtein kinase
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498122218_109246413.0DomainPB1
TgeneMAP2K5chr15:68379088chr15:67984817ENST000003954761221166_409282439.0DomainProtein kinase
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476122118_109282439.0DomainPB1
TgeneMAP2K5chr15:68379088chr15:67984817ENST000001786401222172_180282449.0Nucleotide bindingATP
TgeneMAP2K5chr15:68379088chr15:67984817ENST000003544981222172_180246413.0Nucleotide bindingATP
TgeneMAP2K5chr15:68379088chr15:67984817ENST000003954761221172_180282439.0Nucleotide bindingATP


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Fusion Gene Sequence for PIAS1-MAP2K5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65103_65103_1_PIAS1-MAP2K5_PIAS1_chr15_68379088_ENST00000249636_MAP2K5_chr15_67984817_ENST00000178640_length(transcript)=1490nt_BP=617nt
GGGGCTTCGAGCGCCCTGAGCGGGGCGGAGGCTAGAGGCGGGCTGGGAAGGTGGAGGGGCGGGCCGGGGCGGGGCCAGGCCGGCTAGAGG
GGCGGGTCTAGCGGCGGCCCCCGGCGAAGTTCACTGCGCTTGCGCTGACAGACGCAAGATGGCGGACAGTGCGGAACTAAAGCAAATGGT
TATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGAAACAAGCACGGACGCAAACACGAACTTCTCACAAAAGC
CCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAGGAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGAC
GCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACTTTGTCTCCATCTACCATTCCACAACTCACTTACGATGG
TCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACATGAACTGGAACTCCCACATCTTACATCAGCTCTTCACCC
AGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGATGAACTGATAAAACCCACCAGTCTAGACGTGAAGCCCTC
CAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGT
TGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTAT
GGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGA
TGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAG
GCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGC
GCTGGAGGAGAGGCGGAGCCAGCAGGGGCCCCCGTGAGGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACCAAGGAGAACAACCCA
CCCGTCGCCCTTCTCCGTATGCTGCCTGCGCCAGAAGAGCTTTGCTGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGT
GGCCTTGCCTGGGGAGCCCCATGTGTGGCCCACCCCACCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGACACTGGCAGAGAGGT
AAAGGGTGGGGCATTGAGAATGGAGGCTCCCAGGGTCCCTGCCCACTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTC

>65103_65103_1_PIAS1-MAP2K5_PIAS1_chr15_68379088_ENST00000249636_MAP2K5_chr15_67984817_ENST00000178640_length(amino acids)=322AA_BP=155
MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPATLS
PSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLDVKPSNMLVNTRGQVKLCDFGVST
QLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFI

--------------------------------------------------------------
>65103_65103_2_PIAS1-MAP2K5_PIAS1_chr15_68379088_ENST00000545237_MAP2K5_chr15_67984817_ENST00000178640_length(transcript)=2089nt_BP=1216nt
TTGTTGTGGGCGCCTCTGGCGGGGGTGGCGGGGGAAGAGATAGGGAGTCCGGAGGTAGGGGCTGCAGCTGTCTCATGGGCTCGGCTTTTT
CACCTTCCAGTTAGCCTCCCTGCCCCCCATGGGGAGCTGGGGCTGGGGGCAGGGTGCTCTCGTAGGGGGGATTGGGAAAGCTCCCCGTGG
CCGCTTCCTCTTCCTCCTTTGCAGTCCCGGGCTCCTGTCAGGCGCTCTTCTCAGACCCCCGGGAACTTGGCTTCGGCCGCCCCGCCCCTC
CGTGGATCCCAGTAGCCCCCGCCCCGGACTCGGCTTTCCCCGGCTGCTCGCTTGTCAGGAAGCGCCTGGGGTGCCCCGCTTGTGGGAAGC
GCGATCCCGGGGCGATAGGGTGGGGATCTGGGGGAGAAGCTCTGGTAAAGTTTAGCGAGCCCCGGGCCGGCGTTGGGGTTCGGCTGAGAG
GTAGTGAGCGGGACGTTACTCTTTCTCTCTGATTCCGGGCAGCCGAGGGGAGAAACCCCCTCGAAGAGTGTGTCTTTGGAAGCAGTGTTG
GGAGGGGGGGATGCAGCTACCTCTCTCCCTTCTTTTGCCTTAGCTGGTGTGGAGGGTGAGAGGAGCCTTTGGGGGTCTCTGCACACACCA
TGATGGCGATGCTGTAGCTGATGGAGAACAACCAAATGCCAGATTTGATTCTGTAGAGTTTTTCCTGTGGAATATCCTCACCGAAAGAGC
TTTTCTCCTAATAACTTCACAATGTTTACACTCCAAGATTCGTATGTTAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTA
CTGTTGGGCTACGCCGGGAGAAACAAGCACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCT
GCTGTGCAAATGAAAATTAAGGAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACAT
TCAAGTCCTATGCCAGCAACTTTGTCTCCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTT
TCTCTTCTGGGACCTAAACATGAACTGGAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTA
CCATTTTATGATTTACTGGATGAACTGATAAAACCCACCAGTCTAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTT
AAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGG
ATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCT
CAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAG
TTCTCGGAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCG
TTCATCGTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGCGCTGGAGGAGAGGCGGAGCCAGCAGGGGCCC
CCGTGAGGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACCAAGGAGAACAACCCACCCGTCGCCCTTCTCCGTATGCTGCCTGCGC
CAGAAGAGCTTTGCTGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGTGGCCTTGCCTGGGGAGCCCCATGTGTGGCCC
ACCCCACCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGACACTGGCAGAGAGGTAAAGGGTGGGGCATTGAGAATGGAGGCTCCC
AGGGTCCCTGCCCACTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTCAGCATCACTGATGGGAATAAAAGTATTAATG

>65103_65103_2_PIAS1-MAP2K5_PIAS1_chr15_68379088_ENST00000545237_MAP2K5_chr15_67984817_ENST00000178640_length(amino acids)=324AA_BP=157
MFTLQDSYVKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPAT
LSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLDVKPSNMLVNTRGQVKLCDFGV
STQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVH

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Fusion Gene PPI Analysis for PIAS1-MAP2K5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640122264_68282.3333333333333449.0MAP3K2/MAP3K3
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498122264_68246.33333333333334413.0MAP3K2/MAP3K3
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476122164_68282.3333333333333439.0MAP3K2/MAP3K3
TgeneMAP2K5chr15:68379088chr15:67984817ENST000001786401222117_131282.3333333333333449.0MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640122218_25282.3333333333333449.0MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST000003544981222117_131246.33333333333334413.0MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498122218_25246.33333333333334413.0MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST000003954761221117_131282.3333333333333439.0MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476122118_25282.3333333333333439.0MAPK7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIAS1-MAP2K5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIAS1-MAP2K5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource