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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIAS3-BZRAP1 (FusionGDB2 ID:65119)

Fusion Gene Summary for PIAS3-BZRAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PIAS3-BZRAP1
Fusion gene ID: 65119
HgeneTgene
Gene symbol

PIAS3

BZRAP1

Gene ID

10401

9256

Gene nameprotein inhibitor of activated STAT 3TSPO associated protein 1
SynonymsZMIZ5BZRAP1|PBR-IP|PRAX-1|PRAX1|RIM-BP1|RIMBP1
Cytomap

1q21.1

17q22

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase PIAS3E3 SUMO-protein transferase PIAS3protein inhibitor of activated STAT protein 3zinc finger, MIZ-type containing 5peripheral-type benzodiazepine receptor-associated protein 1RIMS-binding protein 1benzodiazapine receptor peripheral-associated protein 1benzodiazepine receptor (peripheral) associated protein 1peripheral benzodiazepine receptor-interacting protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000369298, ENST00000393045, 
ENST00000369299, 		ENST00000268893, 
ENST00000343736, ENST00000355701, 
Fusion gene scores* DoF score5 X 6 X 3=901 X 1 X 1=1
# samples 61
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: PIAS3 [Title/Abstract] AND BZRAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIAS3(145584836)-BZRAP1(56384329), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIAS3

GO:0033234

negative regulation of protein sumoylation

24651376

HgenePIAS3

GO:0033235

positive regulation of protein sumoylation

17696781|21965678


check buttonFusion gene breakpoints across PIAS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BZRAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB3A-01APIAS3chr1

145584836

-BZRAP1chr17

56384329

-


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Fusion Gene ORF analysis for PIAS3-BZRAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000369298ENST00000268893PIAS3chr1

145584836

-BZRAP1chr17

56384329

-
In-frameENST00000369298ENST00000343736PIAS3chr1

145584836

-BZRAP1chr17

56384329

-
In-frameENST00000369298ENST00000355701PIAS3chr1

145584836

-BZRAP1chr17

56384329

-
In-frameENST00000393045ENST00000268893PIAS3chr1

145584836

-BZRAP1chr17

56384329

-
In-frameENST00000393045ENST00000343736PIAS3chr1

145584836

-BZRAP1chr17

56384329

-
In-frameENST00000393045ENST00000355701PIAS3chr1

145584836

-BZRAP1chr17

56384329

-
intron-3CDSENST00000369299ENST00000268893PIAS3chr1

145584836

-BZRAP1chr17

56384329

-
intron-3CDSENST00000369299ENST00000343736PIAS3chr1

145584836

-BZRAP1chr17

56384329

-
intron-3CDSENST00000369299ENST00000355701PIAS3chr1

145584836

-BZRAP1chr17

56384329

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393045PIAS3chr1145584836-ENST00000268893BZRAP1chr1756384329-35501710662300744
ENST00000393045PIAS3chr1145584836-ENST00000355701BZRAP1chr1756384329-34821710662450794
ENST00000393045PIAS3chr1145584836-ENST00000343736BZRAP1chr1756384329-25101710662300744
ENST00000369298PIAS3chr1145584836-ENST00000268893BZRAP1chr1756384329-34101570312160709
ENST00000369298PIAS3chr1145584836-ENST00000355701BZRAP1chr1756384329-33421570312310759
ENST00000369298PIAS3chr1145584836-ENST00000343736BZRAP1chr1756384329-23701570312160709

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393045ENST00000268893PIAS3chr1145584836-BZRAP1chr1756384329-0.0038338580.9961661
ENST00000393045ENST00000355701PIAS3chr1145584836-BZRAP1chr1756384329-0.0031914470.99680847
ENST00000393045ENST00000343736PIAS3chr1145584836-BZRAP1chr1756384329-0.0052633880.9947366
ENST00000369298ENST00000268893PIAS3chr1145584836-BZRAP1chr1756384329-0.0072192140.99278075
ENST00000369298ENST00000355701PIAS3chr1145584836-BZRAP1chr1756384329-0.0062862790.9937137
ENST00000369298ENST00000343736PIAS3chr1145584836-BZRAP1chr1756384329-0.0090788750.99092114

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Fusion Genomic Features for PIAS3-BZRAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PIAS3-BZRAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:145584836/chr17:56384329)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIAS3chr1:145584836chr17:56384329ENST00000393045-131481_133540629.0Compositional biasNote=Pro-rich
HgenePIAS3chr1:145584836chr17:56384329ENST00000393045-1314115_280540629.0DomainPINIT
HgenePIAS3chr1:145584836chr17:56384329ENST00000393045-131411_45540629.0DomainSAP
HgenePIAS3chr1:145584836chr17:56384329ENST00000393045-131419_23540629.0MotifNote=LXXLL motif
HgenePIAS3chr1:145584836chr17:56384329ENST00000393045-1314450_460540629.0RegionSUMO1-binding
HgenePIAS3chr1:145584836chr17:56384329ENST00000393045-1314303_380540629.0Zinc fingerSP-RING-type
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000026889322311625_169316011797.3333333333333DomainSH3 2
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000026889322311764_183116011797.3333333333333DomainSH3 3
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000034373623321764_183116611736.0DomainSH3 3
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000035570123311764_183116611908.0DomainSH3 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000026889322311071_115016011797.3333333333333Compositional biasNote=Pro-rich
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000026889322311262_127416011797.3333333333333Compositional biasNote=Poly-Glu
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000026889322311334_134616011797.3333333333333Compositional biasNote=Poly-Glu
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000034373623321071_115016611736.0Compositional biasNote=Pro-rich
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000034373623321262_127416611736.0Compositional biasNote=Poly-Glu
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000034373623321334_134616611736.0Compositional biasNote=Poly-Glu
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000035570123311071_115016611908.0Compositional biasNote=Pro-rich
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000035570123311262_127416611908.0Compositional biasNote=Poly-Glu
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000035570123311334_134616611908.0Compositional biasNote=Poly-Glu
TgeneBZRAP1chr1:145584836chr17:56384329ENST000002688932231653_72016011797.3333333333333DomainSH3 1
TgeneBZRAP1chr1:145584836chr17:56384329ENST000002688932231791_88216011797.3333333333333DomainFibronectin type-III 1
TgeneBZRAP1chr1:145584836chr17:56384329ENST000002688932231884_97616011797.3333333333333DomainFibronectin type-III 2
TgeneBZRAP1chr1:145584836chr17:56384329ENST000002688932231981_108116011797.3333333333333DomainFibronectin type-III 3
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000034373623321625_169316611736.0DomainSH3 2
TgeneBZRAP1chr1:145584836chr17:56384329ENST000003437362332653_72016611736.0DomainSH3 1
TgeneBZRAP1chr1:145584836chr17:56384329ENST000003437362332791_88216611736.0DomainFibronectin type-III 1
TgeneBZRAP1chr1:145584836chr17:56384329ENST000003437362332884_97616611736.0DomainFibronectin type-III 2
TgeneBZRAP1chr1:145584836chr17:56384329ENST000003437362332981_108116611736.0DomainFibronectin type-III 3
TgeneBZRAP1chr1:145584836chr17:56384329ENST0000035570123311625_169316611908.0DomainSH3 2
TgeneBZRAP1chr1:145584836chr17:56384329ENST000003557012331653_72016611908.0DomainSH3 1
TgeneBZRAP1chr1:145584836chr17:56384329ENST000003557012331791_88216611908.0DomainFibronectin type-III 1
TgeneBZRAP1chr1:145584836chr17:56384329ENST000003557012331884_97616611908.0DomainFibronectin type-III 2
TgeneBZRAP1chr1:145584836chr17:56384329ENST000003557012331981_108116611908.0DomainFibronectin type-III 3


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Fusion Gene Sequence for PIAS3-BZRAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65119_65119_1_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000369298_BZRAP1_chr17_56384329_ENST00000268893_length(transcript)=3410nt_BP=1570nt
GCCGGTCCCTGGGCCTGAGCTCCGGCTCCGGCTGGGGCGCCTGCGATGTCTCAAGATGGCGGAGCTGGGCGAATTAAAGCACATGGTGAT
GAGTTTCCGGGTGTCTGAGCTCCAGGTGCTTCTTGGCTTTGCTGGCCGGAACAAGAGTGGACGGAAGCACGAGCTCCTGGCCAAGGCTCT
GCACCTCCTGAAGTCCAGCTGTGCCCCTAGTGTCCAGATGAAGATCAAAGAGCTTTACCGACGACGCTTTCCCCGGAAGACCCTGGGGCC
CTCTGATCTCTCCCTTCTCTCTTTGCCCCCTGGCACCTCTCCTCCTGTGCACCCTGATGTCACCATGAAACCATTGCCCTTCTATGAAGT
CTATGGGGAGCTCATCCGGCCCACCACCCTTGCATCCACTTCTAGCCAGCGGTTTGAGGAAGCGCACTTTACCTTTGCCCTCACACCCCA
GCAAGTGCAGCAGATTCTTACATCCAGAGAGGTTCTGCCAGGAGCCAAATGTGATTATACCATACAGGTGCAGCTAAGGTTCTGTCTCTG
TGAGACCAGCTGCCCCCAGGAAGATTATTTTCCCCCCAACCTCTTTGTCAAGGTCAATGGGAAACTGTGCCCCCTGCCGGGTTACCTTCC
CCCAACCAAGAATGGGGCCGAGCCCAAGAGGCCCAGCCGCCCCATCAACATCACACCCCTGGCTCGACTCTCAGCCACTGTTCCCAACAC
CATTGTGGTCAATTGGTCATCTGAGTTCGGACGGAATTACTCCTTGTCTGTGTACCTGGTGAGGCAGTTGACTGCAGGAACCCTTCTACA
AAAACTCAGAGCAAAGGGTATCCGGAACCCAGACCACTCGCGGGCACTGATCAAGGAGAAATTGACTGCTGACCCTGACAGTGAGGTGGC
CACTACAAGTCTCCGGGTGTCACTCATGTGCCCGCTAGGGAAGATGCGCCTGACTGTCCCTTGTCGTGCCCTCACCTGCGCCCACCTGCA
GAGCTTCGATGCTGCCCTTTATCTACAGATGAATGAGAAGAAGCCTACATGGACATGTCCTGTGTGTGACAAGAAGGCTCCCTATGAATC
TCTTATCATTGATGGTTTATTTATGGAGATTCTTAGTTCCTGTTCAGATTGTGATGAGATCCAATTCATGGAAGATGGATCCTGGTGCCC
AATGAAACCCAAGAAGGAGGCATCTGAGGTTTGCCCCCCGCCAGGGTATGGGCTGGATGGCCTCCAGTACAGCCCAGTCCAGGGGGGAGA
TCCATCAGAGAATAAGAAGAAGGTCGAAGTTATTGACTTGACAATAGAAAGCTCATCAGATGAGGAGGATCTGCCCCCTACCAAGAAGCA
CTGTTCTGTCACCTCAGCTGCCATCCCGGCCCTACCTGGAAGCAAAGGAGTCCTGACATCTGGCCACCAGCCATCCTCGGTGCTAAGGAG
CCCTGCTATGGGCACGTTGGGTGGGGATTTCCTGTCCAGTCTCCCACTACATGAGTACCCACCTGCCTTCCCACTGGGAGCCGACATCCA
AGGTTTAGATTTATTTTCATTTCTTCAGACAGAGAGTCAGGTGTTTGGGGACAAGGATGCCGATGGCTTCTACCAGGGCGAAGGTGGGGG
CCGGACAGGCTACATTCCCTGCAACATGGTGGCTGAGGTGGCTGTGGACAGCCCTGCTGGGAGACAGCAACTGCTCCAGCGGGGTTATTT
GTCCCCAGATATTCTCCTTGAGGGCTCAGGGAATGGTCCGTTTGTGTACTCCACAGCCCACACAACTGGGCCTCCTCCCAAGCCCCGCCG
CTCCAAGAAAGCTGAGTCGGAAGGCCCTGCCCAGCCCTGTCCAGGCCCCCCTAAGCTGGTCCCCTCTGCTGACCTGAAAGCTCCCCACTC
CATGGTGGCTGCATTTGACTACAACCCCCAGGAGAGTTCCCCCAATATGGACGTGGAGGCAGAGCTGCCCTTCCGGGCAGGGGATGTCAT
TACTGTGTTTGGGGGCATGGACGATGACGGTTTCTACTATGGGGAATTAAATGGACAAAGGGGCCTGGTTCCATCCAACTTCCTGGAGGG
CCCTGGGCCTGAGGCAGGCGGCCTGGACAGGGAACCCAGGACACCCCAGGCTGAGAGTCAGAGAACGAGGAGGAGAAGAGTCCAGTGCTA
GATGGAGATAGATATATGTAGAGAGAGCAACATGACTGGGGCTGCACCACACAAGGGTCCCCAGGGCCCCCAGGTGGGCCTTGTACCCCC
AGCTCTGGCAGCGCCCCCAGGATTGAACGTGGGGAGCCCCAGGGCAGAAGCGAGAAGGTGTGGGGTTTCTTCTCCAAGGGGAAGCAGCTC
CTCAGGAGGCTGGGCTCTGGGAAGAAGGAGTGAAGCTGTGGCCCATCCTGCAGGCAGAAGAGGCCCTGAGAGGCCCCCAGATCACTGTCT
CTGCTGAGCAGGGAAGGCTCAGACTGGGCCCAGAGCCCCCGTTCTTCTGCGTTAACACTGTGGCATTCAGAGGGAATCAAAGAGCCTTGG
TGAAGGTCAGAGCTAAATGGCTCCTTAAGGATGAACTCTCTAGAGAAGCACCTTCCTCCTACAGGAGGGGAAACTGAGCCCACAGTGAGT
ATGTAACTTGACCAAGGTCACTGAGCCAGGACTGGACCCAGGACCCTCGCGTCCTGGTCCACCCACCTCGTCTACTAGTGTCCCACAGTG
CTGCGCTAGTCCCTTCTGCCACCCTTCCCAGTCCCAGGACGGGCCCTGGAGGGAGAAAGGAGCCTGTGCCCCCTGATGGCTCTGGCTGTC
CTGATCCTGTCTTCCCTCCCCTGAAGGAAAGTTTGCACTGGATTTTATTGGAGCCCCATCTCCCCAGCGGGCAGGCGGGCGGAGCCTGTA
TATATGTATATACTCAGTGCCTCAGTTCAGCTTCCTCCACCTCGCTTCCACTGCACAGGCCCAGGAAGGAGAAAGGCCAAGCCAAAGTGG
GCCCCACCCTGCCCCCGTCGTGCTCCATCCTTCCCTGCCGGGGCCTGCTGGCCCCTGTAAGGTCCCGCCCCCAAAGACCCTGGGGCCAGC
GGGGCCGAAAGCGGAGTTGGGTTTGCCTTATTTTGCTCATTGGATTCAAGTTCTTTTGCATAGTTTTCTTCTAACCCCTGTTGGAGTCCA
GGGGCTGGAGAAAAGGACAGATTTATGCAGCTATTTTCATACATTCCCTGTTCAGAGTGGGGTAGGGGTTCTCCGCCGTTACCCGATCCA
CTCCATCCCCCACCCTCTGAGGGGTGAGTGTGTCTTTGCATGTTTCCTTTGCTGTGGTGGGAGATAGTTTGACTGAACCCCCACCTTGAC

>65119_65119_1_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000369298_BZRAP1_chr17_56384329_ENST00000268893_length(amino acids)=709AA_BP=512
MGRLRCLKMAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPP
GTSPPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYF
PPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP
DHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEI
LSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPA
LPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQVFGDKDADGFYQGEGGGRTGYIPCNMV
AEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQ

--------------------------------------------------------------
>65119_65119_2_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000369298_BZRAP1_chr17_56384329_ENST00000343736_length(transcript)=2370nt_BP=1570nt
GCCGGTCCCTGGGCCTGAGCTCCGGCTCCGGCTGGGGCGCCTGCGATGTCTCAAGATGGCGGAGCTGGGCGAATTAAAGCACATGGTGAT
GAGTTTCCGGGTGTCTGAGCTCCAGGTGCTTCTTGGCTTTGCTGGCCGGAACAAGAGTGGACGGAAGCACGAGCTCCTGGCCAAGGCTCT
GCACCTCCTGAAGTCCAGCTGTGCCCCTAGTGTCCAGATGAAGATCAAAGAGCTTTACCGACGACGCTTTCCCCGGAAGACCCTGGGGCC
CTCTGATCTCTCCCTTCTCTCTTTGCCCCCTGGCACCTCTCCTCCTGTGCACCCTGATGTCACCATGAAACCATTGCCCTTCTATGAAGT
CTATGGGGAGCTCATCCGGCCCACCACCCTTGCATCCACTTCTAGCCAGCGGTTTGAGGAAGCGCACTTTACCTTTGCCCTCACACCCCA
GCAAGTGCAGCAGATTCTTACATCCAGAGAGGTTCTGCCAGGAGCCAAATGTGATTATACCATACAGGTGCAGCTAAGGTTCTGTCTCTG
TGAGACCAGCTGCCCCCAGGAAGATTATTTTCCCCCCAACCTCTTTGTCAAGGTCAATGGGAAACTGTGCCCCCTGCCGGGTTACCTTCC
CCCAACCAAGAATGGGGCCGAGCCCAAGAGGCCCAGCCGCCCCATCAACATCACACCCCTGGCTCGACTCTCAGCCACTGTTCCCAACAC
CATTGTGGTCAATTGGTCATCTGAGTTCGGACGGAATTACTCCTTGTCTGTGTACCTGGTGAGGCAGTTGACTGCAGGAACCCTTCTACA
AAAACTCAGAGCAAAGGGTATCCGGAACCCAGACCACTCGCGGGCACTGATCAAGGAGAAATTGACTGCTGACCCTGACAGTGAGGTGGC
CACTACAAGTCTCCGGGTGTCACTCATGTGCCCGCTAGGGAAGATGCGCCTGACTGTCCCTTGTCGTGCCCTCACCTGCGCCCACCTGCA
GAGCTTCGATGCTGCCCTTTATCTACAGATGAATGAGAAGAAGCCTACATGGACATGTCCTGTGTGTGACAAGAAGGCTCCCTATGAATC
TCTTATCATTGATGGTTTATTTATGGAGATTCTTAGTTCCTGTTCAGATTGTGATGAGATCCAATTCATGGAAGATGGATCCTGGTGCCC
AATGAAACCCAAGAAGGAGGCATCTGAGGTTTGCCCCCCGCCAGGGTATGGGCTGGATGGCCTCCAGTACAGCCCAGTCCAGGGGGGAGA
TCCATCAGAGAATAAGAAGAAGGTCGAAGTTATTGACTTGACAATAGAAAGCTCATCAGATGAGGAGGATCTGCCCCCTACCAAGAAGCA
CTGTTCTGTCACCTCAGCTGCCATCCCGGCCCTACCTGGAAGCAAAGGAGTCCTGACATCTGGCCACCAGCCATCCTCGGTGCTAAGGAG
CCCTGCTATGGGCACGTTGGGTGGGGATTTCCTGTCCAGTCTCCCACTACATGAGTACCCACCTGCCTTCCCACTGGGAGCCGACATCCA
AGGTTTAGATTTATTTTCATTTCTTCAGACAGAGAGTCAGGTGTTTGGGGACAAGGATGCCGATGGCTTCTACCAGGGCGAAGGTGGGGG
CCGGACAGGCTACATTCCCTGCAACATGGTGGCTGAGGTGGCTGTGGACAGCCCTGCTGGGAGACAGCAACTGCTCCAGCGGGGTTATTT
GTCCCCAGATATTCTCCTTGAGGGCTCAGGGAATGGTCCGTTTGTGTACTCCACAGCCCACACAACTGGGCCTCCTCCCAAGCCCCGCCG
CTCCAAGAAAGCTGAGTCGGAAGGCCCTGCCCAGCCCTGTCCAGGCCCCCCTAAGCTGGTCCCCTCTGCTGACCTGAAAGCTCCCCACTC
CATGGTGGCTGCATTTGACTACAACCCCCAGGAGAGTTCCCCCAATATGGACGTGGAGGCAGAGCTGCCCTTCCGGGCAGGGGATGTCAT
TACTGTGTTTGGGGGCATGGACGATGACGGTTTCTACTATGGGGAATTAAATGGACAAAGGGGCCTGGTTCCATCCAACTTCCTGGAGGG
CCCTGGGCCTGAGGCAGGCGGCCTGGACAGGGAACCCAGGACACCCCAGGCTGAGAGTCAGAGAACGAGGAGGAGAAGAGTCCAGTGCTA
GATGGAGATAGATATATGTAGAGAGAGCAACATGACTGGGGCTGCACCACACAAGGGTCCCCAGGGCCCCCAGGTGGGCCTTGTACCCCC
AGCTCTGGCAGCGCCCCCAGGATTGAACGTGGGGAGCCCCAGGGCAGAAGCGAGAAGGTGTGGGGTTTCTTCTCCAAGGGGAAGCAGCTC

>65119_65119_2_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000369298_BZRAP1_chr17_56384329_ENST00000343736_length(amino acids)=709AA_BP=512
MGRLRCLKMAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPP
GTSPPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYF
PPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP
DHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEI
LSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPA
LPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQVFGDKDADGFYQGEGGGRTGYIPCNMV
AEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQ

--------------------------------------------------------------
>65119_65119_3_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000369298_BZRAP1_chr17_56384329_ENST00000355701_length(transcript)=3342nt_BP=1570nt
GCCGGTCCCTGGGCCTGAGCTCCGGCTCCGGCTGGGGCGCCTGCGATGTCTCAAGATGGCGGAGCTGGGCGAATTAAAGCACATGGTGAT
GAGTTTCCGGGTGTCTGAGCTCCAGGTGCTTCTTGGCTTTGCTGGCCGGAACAAGAGTGGACGGAAGCACGAGCTCCTGGCCAAGGCTCT
GCACCTCCTGAAGTCCAGCTGTGCCCCTAGTGTCCAGATGAAGATCAAAGAGCTTTACCGACGACGCTTTCCCCGGAAGACCCTGGGGCC
CTCTGATCTCTCCCTTCTCTCTTTGCCCCCTGGCACCTCTCCTCCTGTGCACCCTGATGTCACCATGAAACCATTGCCCTTCTATGAAGT
CTATGGGGAGCTCATCCGGCCCACCACCCTTGCATCCACTTCTAGCCAGCGGTTTGAGGAAGCGCACTTTACCTTTGCCCTCACACCCCA
GCAAGTGCAGCAGATTCTTACATCCAGAGAGGTTCTGCCAGGAGCCAAATGTGATTATACCATACAGGTGCAGCTAAGGTTCTGTCTCTG
TGAGACCAGCTGCCCCCAGGAAGATTATTTTCCCCCCAACCTCTTTGTCAAGGTCAATGGGAAACTGTGCCCCCTGCCGGGTTACCTTCC
CCCAACCAAGAATGGGGCCGAGCCCAAGAGGCCCAGCCGCCCCATCAACATCACACCCCTGGCTCGACTCTCAGCCACTGTTCCCAACAC
CATTGTGGTCAATTGGTCATCTGAGTTCGGACGGAATTACTCCTTGTCTGTGTACCTGGTGAGGCAGTTGACTGCAGGAACCCTTCTACA
AAAACTCAGAGCAAAGGGTATCCGGAACCCAGACCACTCGCGGGCACTGATCAAGGAGAAATTGACTGCTGACCCTGACAGTGAGGTGGC
CACTACAAGTCTCCGGGTGTCACTCATGTGCCCGCTAGGGAAGATGCGCCTGACTGTCCCTTGTCGTGCCCTCACCTGCGCCCACCTGCA
GAGCTTCGATGCTGCCCTTTATCTACAGATGAATGAGAAGAAGCCTACATGGACATGTCCTGTGTGTGACAAGAAGGCTCCCTATGAATC
TCTTATCATTGATGGTTTATTTATGGAGATTCTTAGTTCCTGTTCAGATTGTGATGAGATCCAATTCATGGAAGATGGATCCTGGTGCCC
AATGAAACCCAAGAAGGAGGCATCTGAGGTTTGCCCCCCGCCAGGGTATGGGCTGGATGGCCTCCAGTACAGCCCAGTCCAGGGGGGAGA
TCCATCAGAGAATAAGAAGAAGGTCGAAGTTATTGACTTGACAATAGAAAGCTCATCAGATGAGGAGGATCTGCCCCCTACCAAGAAGCA
CTGTTCTGTCACCTCAGCTGCCATCCCGGCCCTACCTGGAAGCAAAGGAGTCCTGACATCTGGCCACCAGCCATCCTCGGTGCTAAGGAG
CCCTGCTATGGGCACGTTGGGTGGGGATTTCCTGTCCAGTCTCCCACTACATGAGTACCCACCTGCCTTCCCACTGGGAGCCGACATCCA
AGGTTTAGATTTATTTTCATTTCTTCAGACAGAGAGTCAGGTGTTTGGGGACAAGGATGCCGATGGCTTCTACCAGGGCGAAGGTGGGGG
CCGGACAGGCTACATTCCCTGCAACATGGTGGCTGAGGTGGCTGTGGACAGCCCTGCTGGGAGACAGCAACTGCTCCAGCGGGGTTATTT
GTCCCCAGATATTCTCCTTGAGGGCTCAGGGAATGGTCCGTTTGTGTACTCCACAGCCCACACAACTGGGCCTCCTCCCAAGCCCCGCCG
CTCCAAGAAAGCTGAGTCGGAAGGCCCTGCCCAGCCCTGTCCAGGCCCCCCTAAGCTGGTCCCCTCTGCTGACCTGAAAGCTCCCCACTC
CATGGTGGCTGCATTTGACTACAACCCCCAGGAGAGTTCCCCCAATATGGACGTGGAGGCAGAGCTGCCCTTCCGGGCAGGGGATGTCAT
TACTGTGTTTGGGGGCATGGACGATGACGGTTTCTACTATGGGGAATTAAATGGACAAAGGGGCCTGGTTCCATCCAACTTCCTGGAGGG
CCCTGGGCCTGAGGCAGGCGGCCTGGACAGGGAACCCAGGACACCCCAGGCTGAGAGTCAGGACTGGGGCTGCACCACACAAGGGTCCCC
AGGGCCCCCAGGTGGGCCTTGTACCCCCAGCTCTGGCAGCGCCCCCAGGATTGAACGTGGGGAGCCCCAGGGCAGAAGCGAGAAGGTGTG
GGGTTTCTTCTCCAAGGGGAAGCAGCTCCTCAGGAGGCTGGGCTCTGGGAAGAAGGAGTGAAGCTGTGGCCCATCCTGCAGGCAGAAGAG
GCCCTGAGAGGCCCCCAGATCACTGTCTCTGCTGAGCAGGGAAGGCTCAGACTGGGCCCAGAGCCCCCGTTCTTCTGCGTTAACACTGTG
GCATTCAGAGGGAATCAAAGAGCCTTGGTGAAGGTCAGAGCTAAATGGCTCCTTAAGGATGAACTCTCTAGAGAAGCACCTTCCTCCTAC
AGGAGGGGAAACTGAGCCCACAGTGAGTATGTAACTTGACCAAGGTCACTGAGCCAGGACTGGACCCAGGACCCTCGCGTCCTGGTCCAC
CCACCTCGTCTACTAGTGTCCCACAGTGCTGCGCTAGTCCCTTCTGCCACCCTTCCCAGTCCCAGGACGGGCCCTGGAGGGAGAAAGGAG
CCTGTGCCCCCTGATGGCTCTGGCTGTCCTGATCCTGTCTTCCCTCCCCTGAAGGAAAGTTTGCACTGGATTTTATTGGAGCCCCATCTC
CCCAGCGGGCAGGCGGGCGGAGCCTGTATATATGTATATACTCAGTGCCTCAGTTCAGCTTCCTCCACCTCGCTTCCACTGCACAGGCCC
AGGAAGGAGAAAGGCCAAGCCAAAGTGGGCCCCACCCTGCCCCCGTCGTGCTCCATCCTTCCCTGCCGGGGCCTGCTGGCCCCTGTAAGG
TCCCGCCCCCAAAGACCCTGGGGCCAGCGGGGCCGAAAGCGGAGTTGGGTTTGCCTTATTTTGCTCATTGGATTCAAGTTCTTTTGCATA
GTTTTCTTCTAACCCCTGTTGGAGTCCAGGGGCTGGAGAAAAGGACAGATTTATGCAGCTATTTTCATACATTCCCTGTTCAGAGTGGGG
TAGGGGTTCTCCGCCGTTACCCGATCCACTCCATCCCCCACCCTCTGAGGGGTGAGTGTGTCTTTGCATGTTTCCTTTGCTGTGGTGGGA
GATAGTTTGACTGAACCCCCACCTTGACCTTGGTCTCCAGGGGTGTGGAATGGTGGGGGAATTTGTTTAAAAAGACATTTTATTATAATA

>65119_65119_3_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000369298_BZRAP1_chr17_56384329_ENST00000355701_length(amino acids)=759AA_BP=512
MGRLRCLKMAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPP
GTSPPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYF
PPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP
DHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEI
LSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPA
LPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQVFGDKDADGFYQGEGGGRTGYIPCNMV
AEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQ
ESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQDWGCTTQGSPGPPGGPCTPS

--------------------------------------------------------------
>65119_65119_4_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000393045_BZRAP1_chr17_56384329_ENST00000268893_length(transcript)=3550nt_BP=1710nt
GCATTTGCGGCCGGCGCCAGGGTGGAGAGTTGTGCGCCGGTCCCTGGGCCTGAGCTCCGGCTCCGGCTGGGGCGCCTGCGATGTCTCAAG
ATGGCGGAGCTGGGCGAATTAAAGCACATGGTGATGAGTTTCCGGGTGTCTGAGCTCCAGGTGCTTCTTGGCTTTGCTGGCCGGAACAAG
AGTGGACGGAAGCACGAGCTCCTGGCCAAGGCTCTGCACCTCCTGAAGTCCAGCTGTGCCCCTAGTGTCCAGATGAAGATCAAAGAGCTT
TACCGACGACGCTTTCCCCGGAAGACCCTGGGGCCCTCTGATCTCTCCCTTCTCTCTTTGCCCCCTGGCACCTCTCCTGTAGGCTCCCCT
GGTCCTCTAGCTCCCATTCCCCCAACGCTGTTGGCCCCTGGCACCCTGCTGGGCCCCAAGCGTGAGGTGGACATGCACCCCCCTCTGCCC
CAGCCTGTGCACCCTGATGTCACCATGAAACCATTGCCCTTCTATGAAGTCTATGGGGAGCTCATCCGGCCCACCACCCTTGCATCCACT
TCTAGCCAGCGGTTTGAGGAAGCGCACTTTACCTTTGCCCTCACACCCCAGCAAGTGCAGCAGATTCTTACATCCAGAGAGGTTCTGCCA
GGAGCCAAATGTGATTATACCATACAGGTGCAGCTAAGGTTCTGTCTCTGTGAGACCAGCTGCCCCCAGGAAGATTATTTTCCCCCCAAC
CTCTTTGTCAAGGTCAATGGGAAACTGTGCCCCCTGCCGGGTTACCTTCCCCCAACCAAGAATGGGGCCGAGCCCAAGAGGCCCAGCCGC
CCCATCAACATCACACCCCTGGCTCGACTCTCAGCCACTGTTCCCAACACCATTGTGGTCAATTGGTCATCTGAGTTCGGACGGAATTAC
TCCTTGTCTGTGTACCTGGTGAGGCAGTTGACTGCAGGAACCCTTCTACAAAAACTCAGAGCAAAGGGTATCCGGAACCCAGACCACTCG
CGGGCACTGATCAAGGAGAAATTGACTGCTGACCCTGACAGTGAGGTGGCCACTACAAGTCTCCGGGTGTCACTCATGTGCCCGCTAGGG
AAGATGCGCCTGACTGTCCCTTGTCGTGCCCTCACCTGCGCCCACCTGCAGAGCTTCGATGCTGCCCTTTATCTACAGATGAATGAGAAG
AAGCCTACATGGACATGTCCTGTGTGTGACAAGAAGGCTCCCTATGAATCTCTTATCATTGATGGTTTATTTATGGAGATTCTTAGTTCC
TGTTCAGATTGTGATGAGATCCAATTCATGGAAGATGGATCCTGGTGCCCAATGAAACCCAAGAAGGAGGCATCTGAGGTTTGCCCCCCG
CCAGGGTATGGGCTGGATGGCCTCCAGTACAGCCCAGTCCAGGGGGGAGATCCATCAGAGAATAAGAAGAAGGTCGAAGTTATTGACTTG
ACAATAGAAAGCTCATCAGATGAGGAGGATCTGCCCCCTACCAAGAAGCACTGTTCTGTCACCTCAGCTGCCATCCCGGCCCTACCTGGA
AGCAAAGGAGTCCTGACATCTGGCCACCAGCCATCCTCGGTGCTAAGGAGCCCTGCTATGGGCACGTTGGGTGGGGATTTCCTGTCCAGT
CTCCCACTACATGAGTACCCACCTGCCTTCCCACTGGGAGCCGACATCCAAGGTTTAGATTTATTTTCATTTCTTCAGACAGAGAGTCAG
GTGTTTGGGGACAAGGATGCCGATGGCTTCTACCAGGGCGAAGGTGGGGGCCGGACAGGCTACATTCCCTGCAACATGGTGGCTGAGGTG
GCTGTGGACAGCCCTGCTGGGAGACAGCAACTGCTCCAGCGGGGTTATTTGTCCCCAGATATTCTCCTTGAGGGCTCAGGGAATGGTCCG
TTTGTGTACTCCACAGCCCACACAACTGGGCCTCCTCCCAAGCCCCGCCGCTCCAAGAAAGCTGAGTCGGAAGGCCCTGCCCAGCCCTGT
CCAGGCCCCCCTAAGCTGGTCCCCTCTGCTGACCTGAAAGCTCCCCACTCCATGGTGGCTGCATTTGACTACAACCCCCAGGAGAGTTCC
CCCAATATGGACGTGGAGGCAGAGCTGCCCTTCCGGGCAGGGGATGTCATTACTGTGTTTGGGGGCATGGACGATGACGGTTTCTACTAT
GGGGAATTAAATGGACAAAGGGGCCTGGTTCCATCCAACTTCCTGGAGGGCCCTGGGCCTGAGGCAGGCGGCCTGGACAGGGAACCCAGG
ACACCCCAGGCTGAGAGTCAGAGAACGAGGAGGAGAAGAGTCCAGTGCTAGATGGAGATAGATATATGTAGAGAGAGCAACATGACTGGG
GCTGCACCACACAAGGGTCCCCAGGGCCCCCAGGTGGGCCTTGTACCCCCAGCTCTGGCAGCGCCCCCAGGATTGAACGTGGGGAGCCCC
AGGGCAGAAGCGAGAAGGTGTGGGGTTTCTTCTCCAAGGGGAAGCAGCTCCTCAGGAGGCTGGGCTCTGGGAAGAAGGAGTGAAGCTGTG
GCCCATCCTGCAGGCAGAAGAGGCCCTGAGAGGCCCCCAGATCACTGTCTCTGCTGAGCAGGGAAGGCTCAGACTGGGCCCAGAGCCCCC
GTTCTTCTGCGTTAACACTGTGGCATTCAGAGGGAATCAAAGAGCCTTGGTGAAGGTCAGAGCTAAATGGCTCCTTAAGGATGAACTCTC
TAGAGAAGCACCTTCCTCCTACAGGAGGGGAAACTGAGCCCACAGTGAGTATGTAACTTGACCAAGGTCACTGAGCCAGGACTGGACCCA
GGACCCTCGCGTCCTGGTCCACCCACCTCGTCTACTAGTGTCCCACAGTGCTGCGCTAGTCCCTTCTGCCACCCTTCCCAGTCCCAGGAC
GGGCCCTGGAGGGAGAAAGGAGCCTGTGCCCCCTGATGGCTCTGGCTGTCCTGATCCTGTCTTCCCTCCCCTGAAGGAAAGTTTGCACTG
GATTTTATTGGAGCCCCATCTCCCCAGCGGGCAGGCGGGCGGAGCCTGTATATATGTATATACTCAGTGCCTCAGTTCAGCTTCCTCCAC
CTCGCTTCCACTGCACAGGCCCAGGAAGGAGAAAGGCCAAGCCAAAGTGGGCCCCACCCTGCCCCCGTCGTGCTCCATCCTTCCCTGCCG
GGGCCTGCTGGCCCCTGTAAGGTCCCGCCCCCAAAGACCCTGGGGCCAGCGGGGCCGAAAGCGGAGTTGGGTTTGCCTTATTTTGCTCAT
TGGATTCAAGTTCTTTTGCATAGTTTTCTTCTAACCCCTGTTGGAGTCCAGGGGCTGGAGAAAAGGACAGATTTATGCAGCTATTTTCAT
ACATTCCCTGTTCAGAGTGGGGTAGGGGTTCTCCGCCGTTACCCGATCCACTCCATCCCCCACCCTCTGAGGGGTGAGTGTGTCTTTGCA
TGTTTCCTTTGCTGTGGTGGGAGATAGTTTGACTGAACCCCCACCTTGACCTTGGTCTCCAGGGGTGTGGAATGGTGGGGGAATTTGTTT

>65119_65119_4_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000393045_BZRAP1_chr17_56384329_ENST00000268893_length(amino acids)=744AA_BP=547
MGRLRCLKMAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPP
GTSPVGSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQI
LTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNW
SSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAA
LYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENK
KKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLF
SFLQTESQVFGDKDADGFYQGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAE
SEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEA

--------------------------------------------------------------
>65119_65119_5_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000393045_BZRAP1_chr17_56384329_ENST00000343736_length(transcript)=2510nt_BP=1710nt
GCATTTGCGGCCGGCGCCAGGGTGGAGAGTTGTGCGCCGGTCCCTGGGCCTGAGCTCCGGCTCCGGCTGGGGCGCCTGCGATGTCTCAAG
ATGGCGGAGCTGGGCGAATTAAAGCACATGGTGATGAGTTTCCGGGTGTCTGAGCTCCAGGTGCTTCTTGGCTTTGCTGGCCGGAACAAG
AGTGGACGGAAGCACGAGCTCCTGGCCAAGGCTCTGCACCTCCTGAAGTCCAGCTGTGCCCCTAGTGTCCAGATGAAGATCAAAGAGCTT
TACCGACGACGCTTTCCCCGGAAGACCCTGGGGCCCTCTGATCTCTCCCTTCTCTCTTTGCCCCCTGGCACCTCTCCTGTAGGCTCCCCT
GGTCCTCTAGCTCCCATTCCCCCAACGCTGTTGGCCCCTGGCACCCTGCTGGGCCCCAAGCGTGAGGTGGACATGCACCCCCCTCTGCCC
CAGCCTGTGCACCCTGATGTCACCATGAAACCATTGCCCTTCTATGAAGTCTATGGGGAGCTCATCCGGCCCACCACCCTTGCATCCACT
TCTAGCCAGCGGTTTGAGGAAGCGCACTTTACCTTTGCCCTCACACCCCAGCAAGTGCAGCAGATTCTTACATCCAGAGAGGTTCTGCCA
GGAGCCAAATGTGATTATACCATACAGGTGCAGCTAAGGTTCTGTCTCTGTGAGACCAGCTGCCCCCAGGAAGATTATTTTCCCCCCAAC
CTCTTTGTCAAGGTCAATGGGAAACTGTGCCCCCTGCCGGGTTACCTTCCCCCAACCAAGAATGGGGCCGAGCCCAAGAGGCCCAGCCGC
CCCATCAACATCACACCCCTGGCTCGACTCTCAGCCACTGTTCCCAACACCATTGTGGTCAATTGGTCATCTGAGTTCGGACGGAATTAC
TCCTTGTCTGTGTACCTGGTGAGGCAGTTGACTGCAGGAACCCTTCTACAAAAACTCAGAGCAAAGGGTATCCGGAACCCAGACCACTCG
CGGGCACTGATCAAGGAGAAATTGACTGCTGACCCTGACAGTGAGGTGGCCACTACAAGTCTCCGGGTGTCACTCATGTGCCCGCTAGGG
AAGATGCGCCTGACTGTCCCTTGTCGTGCCCTCACCTGCGCCCACCTGCAGAGCTTCGATGCTGCCCTTTATCTACAGATGAATGAGAAG
AAGCCTACATGGACATGTCCTGTGTGTGACAAGAAGGCTCCCTATGAATCTCTTATCATTGATGGTTTATTTATGGAGATTCTTAGTTCC
TGTTCAGATTGTGATGAGATCCAATTCATGGAAGATGGATCCTGGTGCCCAATGAAACCCAAGAAGGAGGCATCTGAGGTTTGCCCCCCG
CCAGGGTATGGGCTGGATGGCCTCCAGTACAGCCCAGTCCAGGGGGGAGATCCATCAGAGAATAAGAAGAAGGTCGAAGTTATTGACTTG
ACAATAGAAAGCTCATCAGATGAGGAGGATCTGCCCCCTACCAAGAAGCACTGTTCTGTCACCTCAGCTGCCATCCCGGCCCTACCTGGA
AGCAAAGGAGTCCTGACATCTGGCCACCAGCCATCCTCGGTGCTAAGGAGCCCTGCTATGGGCACGTTGGGTGGGGATTTCCTGTCCAGT
CTCCCACTACATGAGTACCCACCTGCCTTCCCACTGGGAGCCGACATCCAAGGTTTAGATTTATTTTCATTTCTTCAGACAGAGAGTCAG
GTGTTTGGGGACAAGGATGCCGATGGCTTCTACCAGGGCGAAGGTGGGGGCCGGACAGGCTACATTCCCTGCAACATGGTGGCTGAGGTG
GCTGTGGACAGCCCTGCTGGGAGACAGCAACTGCTCCAGCGGGGTTATTTGTCCCCAGATATTCTCCTTGAGGGCTCAGGGAATGGTCCG
TTTGTGTACTCCACAGCCCACACAACTGGGCCTCCTCCCAAGCCCCGCCGCTCCAAGAAAGCTGAGTCGGAAGGCCCTGCCCAGCCCTGT
CCAGGCCCCCCTAAGCTGGTCCCCTCTGCTGACCTGAAAGCTCCCCACTCCATGGTGGCTGCATTTGACTACAACCCCCAGGAGAGTTCC
CCCAATATGGACGTGGAGGCAGAGCTGCCCTTCCGGGCAGGGGATGTCATTACTGTGTTTGGGGGCATGGACGATGACGGTTTCTACTAT
GGGGAATTAAATGGACAAAGGGGCCTGGTTCCATCCAACTTCCTGGAGGGCCCTGGGCCTGAGGCAGGCGGCCTGGACAGGGAACCCAGG
ACACCCCAGGCTGAGAGTCAGAGAACGAGGAGGAGAAGAGTCCAGTGCTAGATGGAGATAGATATATGTAGAGAGAGCAACATGACTGGG
GCTGCACCACACAAGGGTCCCCAGGGCCCCCAGGTGGGCCTTGTACCCCCAGCTCTGGCAGCGCCCCCAGGATTGAACGTGGGGAGCCCC

>65119_65119_5_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000393045_BZRAP1_chr17_56384329_ENST00000343736_length(amino acids)=744AA_BP=547
MGRLRCLKMAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPP
GTSPVGSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQI
LTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNW
SSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAA
LYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENK
KKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLF
SFLQTESQVFGDKDADGFYQGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAE
SEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEA

--------------------------------------------------------------
>65119_65119_6_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000393045_BZRAP1_chr17_56384329_ENST00000355701_length(transcript)=3482nt_BP=1710nt
GCATTTGCGGCCGGCGCCAGGGTGGAGAGTTGTGCGCCGGTCCCTGGGCCTGAGCTCCGGCTCCGGCTGGGGCGCCTGCGATGTCTCAAG
ATGGCGGAGCTGGGCGAATTAAAGCACATGGTGATGAGTTTCCGGGTGTCTGAGCTCCAGGTGCTTCTTGGCTTTGCTGGCCGGAACAAG
AGTGGACGGAAGCACGAGCTCCTGGCCAAGGCTCTGCACCTCCTGAAGTCCAGCTGTGCCCCTAGTGTCCAGATGAAGATCAAAGAGCTT
TACCGACGACGCTTTCCCCGGAAGACCCTGGGGCCCTCTGATCTCTCCCTTCTCTCTTTGCCCCCTGGCACCTCTCCTGTAGGCTCCCCT
GGTCCTCTAGCTCCCATTCCCCCAACGCTGTTGGCCCCTGGCACCCTGCTGGGCCCCAAGCGTGAGGTGGACATGCACCCCCCTCTGCCC
CAGCCTGTGCACCCTGATGTCACCATGAAACCATTGCCCTTCTATGAAGTCTATGGGGAGCTCATCCGGCCCACCACCCTTGCATCCACT
TCTAGCCAGCGGTTTGAGGAAGCGCACTTTACCTTTGCCCTCACACCCCAGCAAGTGCAGCAGATTCTTACATCCAGAGAGGTTCTGCCA
GGAGCCAAATGTGATTATACCATACAGGTGCAGCTAAGGTTCTGTCTCTGTGAGACCAGCTGCCCCCAGGAAGATTATTTTCCCCCCAAC
CTCTTTGTCAAGGTCAATGGGAAACTGTGCCCCCTGCCGGGTTACCTTCCCCCAACCAAGAATGGGGCCGAGCCCAAGAGGCCCAGCCGC
CCCATCAACATCACACCCCTGGCTCGACTCTCAGCCACTGTTCCCAACACCATTGTGGTCAATTGGTCATCTGAGTTCGGACGGAATTAC
TCCTTGTCTGTGTACCTGGTGAGGCAGTTGACTGCAGGAACCCTTCTACAAAAACTCAGAGCAAAGGGTATCCGGAACCCAGACCACTCG
CGGGCACTGATCAAGGAGAAATTGACTGCTGACCCTGACAGTGAGGTGGCCACTACAAGTCTCCGGGTGTCACTCATGTGCCCGCTAGGG
AAGATGCGCCTGACTGTCCCTTGTCGTGCCCTCACCTGCGCCCACCTGCAGAGCTTCGATGCTGCCCTTTATCTACAGATGAATGAGAAG
AAGCCTACATGGACATGTCCTGTGTGTGACAAGAAGGCTCCCTATGAATCTCTTATCATTGATGGTTTATTTATGGAGATTCTTAGTTCC
TGTTCAGATTGTGATGAGATCCAATTCATGGAAGATGGATCCTGGTGCCCAATGAAACCCAAGAAGGAGGCATCTGAGGTTTGCCCCCCG
CCAGGGTATGGGCTGGATGGCCTCCAGTACAGCCCAGTCCAGGGGGGAGATCCATCAGAGAATAAGAAGAAGGTCGAAGTTATTGACTTG
ACAATAGAAAGCTCATCAGATGAGGAGGATCTGCCCCCTACCAAGAAGCACTGTTCTGTCACCTCAGCTGCCATCCCGGCCCTACCTGGA
AGCAAAGGAGTCCTGACATCTGGCCACCAGCCATCCTCGGTGCTAAGGAGCCCTGCTATGGGCACGTTGGGTGGGGATTTCCTGTCCAGT
CTCCCACTACATGAGTACCCACCTGCCTTCCCACTGGGAGCCGACATCCAAGGTTTAGATTTATTTTCATTTCTTCAGACAGAGAGTCAG
GTGTTTGGGGACAAGGATGCCGATGGCTTCTACCAGGGCGAAGGTGGGGGCCGGACAGGCTACATTCCCTGCAACATGGTGGCTGAGGTG
GCTGTGGACAGCCCTGCTGGGAGACAGCAACTGCTCCAGCGGGGTTATTTGTCCCCAGATATTCTCCTTGAGGGCTCAGGGAATGGTCCG
TTTGTGTACTCCACAGCCCACACAACTGGGCCTCCTCCCAAGCCCCGCCGCTCCAAGAAAGCTGAGTCGGAAGGCCCTGCCCAGCCCTGT
CCAGGCCCCCCTAAGCTGGTCCCCTCTGCTGACCTGAAAGCTCCCCACTCCATGGTGGCTGCATTTGACTACAACCCCCAGGAGAGTTCC
CCCAATATGGACGTGGAGGCAGAGCTGCCCTTCCGGGCAGGGGATGTCATTACTGTGTTTGGGGGCATGGACGATGACGGTTTCTACTAT
GGGGAATTAAATGGACAAAGGGGCCTGGTTCCATCCAACTTCCTGGAGGGCCCTGGGCCTGAGGCAGGCGGCCTGGACAGGGAACCCAGG
ACACCCCAGGCTGAGAGTCAGGACTGGGGCTGCACCACACAAGGGTCCCCAGGGCCCCCAGGTGGGCCTTGTACCCCCAGCTCTGGCAGC
GCCCCCAGGATTGAACGTGGGGAGCCCCAGGGCAGAAGCGAGAAGGTGTGGGGTTTCTTCTCCAAGGGGAAGCAGCTCCTCAGGAGGCTG
GGCTCTGGGAAGAAGGAGTGAAGCTGTGGCCCATCCTGCAGGCAGAAGAGGCCCTGAGAGGCCCCCAGATCACTGTCTCTGCTGAGCAGG
GAAGGCTCAGACTGGGCCCAGAGCCCCCGTTCTTCTGCGTTAACACTGTGGCATTCAGAGGGAATCAAAGAGCCTTGGTGAAGGTCAGAG
CTAAATGGCTCCTTAAGGATGAACTCTCTAGAGAAGCACCTTCCTCCTACAGGAGGGGAAACTGAGCCCACAGTGAGTATGTAACTTGAC
CAAGGTCACTGAGCCAGGACTGGACCCAGGACCCTCGCGTCCTGGTCCACCCACCTCGTCTACTAGTGTCCCACAGTGCTGCGCTAGTCC
CTTCTGCCACCCTTCCCAGTCCCAGGACGGGCCCTGGAGGGAGAAAGGAGCCTGTGCCCCCTGATGGCTCTGGCTGTCCTGATCCTGTCT
TCCCTCCCCTGAAGGAAAGTTTGCACTGGATTTTATTGGAGCCCCATCTCCCCAGCGGGCAGGCGGGCGGAGCCTGTATATATGTATATA
CTCAGTGCCTCAGTTCAGCTTCCTCCACCTCGCTTCCACTGCACAGGCCCAGGAAGGAGAAAGGCCAAGCCAAAGTGGGCCCCACCCTGC
CCCCGTCGTGCTCCATCCTTCCCTGCCGGGGCCTGCTGGCCCCTGTAAGGTCCCGCCCCCAAAGACCCTGGGGCCAGCGGGGCCGAAAGC
GGAGTTGGGTTTGCCTTATTTTGCTCATTGGATTCAAGTTCTTTTGCATAGTTTTCTTCTAACCCCTGTTGGAGTCCAGGGGCTGGAGAA
AAGGACAGATTTATGCAGCTATTTTCATACATTCCCTGTTCAGAGTGGGGTAGGGGTTCTCCGCCGTTACCCGATCCACTCCATCCCCCA
CCCTCTGAGGGGTGAGTGTGTCTTTGCATGTTTCCTTTGCTGTGGTGGGAGATAGTTTGACTGAACCCCCACCTTGACCTTGGTCTCCAG

>65119_65119_6_PIAS3-BZRAP1_PIAS3_chr1_145584836_ENST00000393045_BZRAP1_chr17_56384329_ENST00000355701_length(amino acids)=794AA_BP=547
MGRLRCLKMAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPP
GTSPVGSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQI
LTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNW
SSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAA
LYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENK
KKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLF
SFLQTESQVFGDKDADGFYQGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAE
SEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEA

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Fusion Gene PPI Analysis for PIAS3-BZRAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePIAS3chr1:145584836chr17:56384329ENST00000393045-13141_200540.0629.0CCAR2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIAS3-BZRAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIAS3-BZRAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource