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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PIAS4-ZFR2 (FusionGDB2 ID:65129)

Fusion Gene Summary for PIAS4-ZFR2

check button Fusion gene summary
Fusion gene informationFusion gene name: PIAS4-ZFR2
Fusion gene ID: 65129
HgeneTgene
Gene symbol

PIAS4

ZFR2

Gene ID

51588

23217

Gene nameprotein inhibitor of activated STAT 4zinc finger RNA binding protein 2
SynonymsPIAS-gamma|PIASY|Piasg|ZMIZ6KIAA1086
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase PIAS4RING-type E3 ubiquitin transferase PIAS4protein inhibitor of activated STAT protein 4protein inhibitor of activated STAT protein PIASyprotein inhibitor of activated STAT protein gammazinc finger, MIZ-type containing 6zinc finger RNA-binding protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262971, ENST00000596144, 
ENST00000439086, ENST00000591712, 
ENST00000591965, ENST00000592398, 
ENST00000262961, 
Fusion gene scores* DoF score7 X 6 X 5=2104 X 4 X 3=48
# samples 95
** MAII scorelog2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PIAS4 [Title/Abstract] AND ZFR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPIAS4(4013347)-ZFR2(3823401), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIAS4

GO:0016925

protein sumoylation

18579533

HgenePIAS4

GO:0033235

positive regulation of protein sumoylation

17696781|21965678

HgenePIAS4

GO:0045892

negative regulation of transcription, DNA-templated

11248056


check buttonFusion gene breakpoints across PIAS4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZFR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-A5RC-01APIAS4chr19

4013347

-ZFR2chr19

3823401

-
ChimerDB4LGGTCGA-HT-A5RC-01APIAS4chr19

4013347

+ZFR2chr19

3823401

-
ChimerDB4LGGTCGA-HT-A5RCPIAS4chr19

4013347

+ZFR2chr19

3823401

-
ChimerDB4LGGTCGA-HT-A5RCPIAS4chr19

4013347

+ZFR2chr19

3825405

-


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Fusion Gene ORF analysis for PIAS4-ZFR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262971ENST00000439086PIAS4chr19

4013347

+ZFR2chr19

3823401

-
5CDS-intronENST00000262971ENST00000439086PIAS4chr19

4013347

+ZFR2chr19

3825405

-
5CDS-intronENST00000262971ENST00000591712PIAS4chr19

4013347

+ZFR2chr19

3823401

-
5CDS-intronENST00000262971ENST00000591712PIAS4chr19

4013347

+ZFR2chr19

3825405

-
5CDS-intronENST00000262971ENST00000591965PIAS4chr19

4013347

+ZFR2chr19

3823401

-
5CDS-intronENST00000262971ENST00000591965PIAS4chr19

4013347

+ZFR2chr19

3825405

-
5CDS-intronENST00000262971ENST00000592398PIAS4chr19

4013347

+ZFR2chr19

3823401

-
5CDS-intronENST00000262971ENST00000592398PIAS4chr19

4013347

+ZFR2chr19

3825405

-
Frame-shiftENST00000262971ENST00000262961PIAS4chr19

4013347

+ZFR2chr19

3825405

-
In-frameENST00000262971ENST00000262961PIAS4chr19

4013347

+ZFR2chr19

3823401

-
intron-3CDSENST00000596144ENST00000262961PIAS4chr19

4013347

+ZFR2chr19

3823401

-
intron-3CDSENST00000596144ENST00000262961PIAS4chr19

4013347

+ZFR2chr19

3825405

-
intron-intronENST00000596144ENST00000439086PIAS4chr19

4013347

+ZFR2chr19

3823401

-
intron-intronENST00000596144ENST00000439086PIAS4chr19

4013347

+ZFR2chr19

3825405

-
intron-intronENST00000596144ENST00000591712PIAS4chr19

4013347

+ZFR2chr19

3823401

-
intron-intronENST00000596144ENST00000591712PIAS4chr19

4013347

+ZFR2chr19

3825405

-
intron-intronENST00000596144ENST00000591965PIAS4chr19

4013347

+ZFR2chr19

3823401

-
intron-intronENST00000596144ENST00000591965PIAS4chr19

4013347

+ZFR2chr19

3825405

-
intron-intronENST00000596144ENST00000592398PIAS4chr19

4013347

+ZFR2chr19

3823401

-
intron-intronENST00000596144ENST00000592398PIAS4chr19

4013347

+ZFR2chr19

3825405

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262971PIAS4chr194013347+ENST00000262961ZFR2chr193823401-41015691032175690

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262971ENST00000262961PIAS4chr194013347+ZFR2chr193823401-0.0089558530.99104416

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Fusion Genomic Features for PIAS4-ZFR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PIAS4-ZFR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:4013347/chr19:3823401)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIAS4chr19:4013347chr19:3823401ENST00000262971+21112_46151511.0DomainSAP
HgenePIAS4chr19:4013347chr19:3823401ENST00000262971+21120_24151511.0MotifLXXLL motif
TgeneZFR2chr19:4013347chr19:3823401ENST00000262961619516_549404940.0Coiled coilOntology_term=ECO:0000255
TgeneZFR2chr19:4013347chr19:3823401ENST0000043908602516_549071.0Coiled coilOntology_term=ECO:0000255
TgeneZFR2chr19:4013347chr19:3823401ENST0000043908602187_265071.0Compositional biasNote=Pro-rich
TgeneZFR2chr19:4013347chr19:3823401ENST00000262961619570_935404940.0DomainDZF
TgeneZFR2chr19:4013347chr19:3823401ENST0000043908602570_935071.0DomainDZF

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIAS4chr19:4013347chr19:3823401ENST00000262971+211464_492151511.0Compositional biasNote=Asp/Glu-rich (acidic)
HgenePIAS4chr19:4013347chr19:3823401ENST00000262971+211119_279151511.0DomainPINIT
HgenePIAS4chr19:4013347chr19:3823401ENST00000262971+211311_388151511.0Zinc fingerSP-RING-type
TgeneZFR2chr19:4013347chr19:3823401ENST00000262961619187_265404940.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for PIAS4-ZFR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65129_65129_1_PIAS4-ZFR2_PIAS4_chr19_4013347_ENST00000262971_ZFR2_chr19_3823401_ENST00000262961_length(transcript)=4101nt_BP=569nt
GGAGGAGCGCGCGCGGGTGCTAATTGGCCCGGGCGGCGGCCCCGCCCGCGAGTGGTGAGCGGTCACGTGACGCGACGGCTGGGGGCTCCC
GGCGCGGGGGACGCTGGTGACCAAGATGGCGGCGGAGCTGGTGGAGGCCAAAAACATGGTGATGAGTTTTCGAGTCTCCGACCTTCAGAT
GCTCCTGGGTTTCGTGGGCCGGAGTAAGAGTGGACTGAAGCACGAGCTCGTCACCAGGGCCCTCCAGCTGGTGCAGTTTGACTGTAGCCC
TGAGCTGTTCAAGAAGATCAAGGAGCTGTACGAGACCCGCTACGCCAAGAAGAACTCGGAGCCTGCCCCACAGCCGCACCGGCCCCTGGA
CCCCCTGACCATGCACTCCACCTACGACCGGGCCGGCGCTGTGCCCAGGACTCCGCTGGCAGGCCCCAATATTGACTACCCCGTGCTCTA
CGGAAAGTACTTAAACGGACTGGGACGGTTGCCCGCCAAGACCCTCAAGCCAGAAGTCCGCCTGGTGAAGCTGCCGTTCTTTAATATGCT
GGATGAGCTGCTGAAGCCCACCGAATTAGGGCCTCCTGAGCCACAGGCAGCAGGCTGCAGACCCCAGTGGGGGAAACCAGCCCAACCTAA
ATTAGAGGGTCCCGGAGCACCTACCCAAGGAGGCTCAAAGGAAGCTCCCGCGGGCTGCTCTGATGCGCAGCCGGTGGGCCCGGAATATGT
GGAGGAGGTGTTCAGCGACGAAGGGCGAGTGCTTCGCTTCCACTGCAAGCTGTGCGAGTGCAGTTTCAACGACCTTAACGCGAAGGACCT
GCACGTGAGGGGGCGGCGGCACCGGCTGCAGTACCGGAAGAAAGTGAACCCGGACCTTCCCATTGCCACGGAGCCCAGCAGCCGGGCTCG
GAAGGTCCTGGAGGAGCGCATGAGGAAGCAGCGGCACCTGGCGGAGGAGCGGCTGGAGCAGCTGCGGCGCTGGCACGCGGAGAGGAGGCG
GCTGGAGGAGGAGCCACCCCAGGACGTGCCGCCCCACGCGCCGCCCGACTGGGCCCAGCCTCTGCTCATGGGCAGGCCGGAGTCACCCGC
CAGCGCCCCACTCCAGCCCGGGCGGCGGCCGGCGTCCAGCGACGACCGGCACGTCATGTGCAAGCACGCCACCATCTACCCCACGGAGCA
GGAGCTCCTGGCCGTGCAGAGGGCCGTGTCCCACGCAGAGCGGGCCCTCAAGCTGGTGTCCGACACACTGGCCGAGGAGGACCGGGGCCG
CCGAGAGGAAGAGGGTGACAAGCGCAGCAGCGTTGCCCCCCAGACTCGGGTCCTGAAAGGCGTCATGCGAGTAGGCATCCTGGCGAAAGG
CCTCCTCCTGCGTGGGGACAGGAACGTGCGCCTCGCTCTGCTCTGCTCCGAGAAGCCCACGCACAGCCTGCTGCGGAGGATCGCCCAGCA
GCTGCCCCGGCAGCTCCAGATGGTGACCGAGGATGAGTATGAGGTCTCCTCCGACCCTGAAGCCAACATTGTCATCTCCTCCTGTGAGGA
GCCCAGGATGCAGGTCACCATATCTGTCACCTCACCTCTGATGCGGGAGGACCCCTCCACAGACCCAGGTGTGGAGGAGCCTCAGGCTGA
TGCAGGTGATGTCCTGAGCCCCAAGAAGTGCCTCGAGTCCCTGGCCGCCCTCCGTCATGCCAGGTGGTTTCAGGCTCGAGCCAGCGGCCT
GCAGCCATGCGTGATCGTCATCAGGGTCCTGAGGGACCTCTGCCGGCGTGTGCCCACCTGGGGGGCCCTGCCAGCCTGGGCCATGGAGCT
GCTGGTGGAGAAGGCTGTGAGCAGTGCGGCTGGGCCCCTGGGCCCCGGGGATGCAGTCAGGCGAGTCCTGGAGTGCGTGGCCACAGGGAC
GCTCCTGACAGACGGGCCCGGGCTCCAGGATCCCTGCGAGAGAGACCAGACAGATGCCCTCGAGCCCATGACCCTCCAAGAGCGGGAAGA
CGTGACCGCCAGCGCCCAGCACGCCCTGCGAATGCTGGCCTTCCGGCAGACCCACAAGGTCCTGGGCATGGATCTCCTGCCGCCCAGACA
CCGGCTGGGGGCCCGCTTCCGGAAGAGGCAACGGGGACCTGGCGAGGGAGAGGAGGGCGCAGGGGAGAAGAAGCGGGGCCGGCGGGGCGG
AGAGGGGCTCGTGTGAGCCGCCTACCTCCCCCACCTGCGGGCCTTTGCATCCCTGCACTCCTGGACGTGTGCGCGCCGACCAATGGCTGC
TTCATCCCCGACGTTGGACAATGGTCATTTCCTTTTGAGTAACGCTCTGTAGGTTTCCTTTAAAACACCTGTGCTTCAGACCGGGCACTG
TGGCTCATGCCTTTAATCCCAGCACTTTGGGAGGCTGAGTTGCTTGAGCCTGAGAGTTCAAGGCCAGCCCAGACAACAGAGTGAGACCCC
CATCTCTCCAAAATATTTTTAAAAATCAGCTTGGCATGGTTGGTGGCCAGGCGCGGTGATTCACGCCTGTAATCCCAGCACTTTGAGAGG
CCGAGGTGGGCAGATCGCCTGAGGTCAGGAGTTCGAGACCGGCCTGGTCAACATGGTGAAACCCTGTCTCTAGTAAAAAACACAACAATT
AGCCTGGCGTGGTGGTGTGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGTCCGGAGCCTTGAGGCCAGGAGGGCAGTGAGCTGTGATT
GCACCGTGACACTCCAGCCTGGGCAACAGAAGAAGACTTTGTCACTTAAAAGAAATGTTTTTTAACATTTGTGCTTAAATTGTTACAGAA
ATGACACCATCCAGCCCTGGGAGTGGCACCCCTTCCTCGAGGGCCCCATCCCCCACAGCCAGGGGGGCCAGCAGTACAGCAAGCAGATTC
TAAACTCGGGGGCATCTTGCTGGCTCTAAACTCACCTCGTGGTACAGGAAGGGGTTTTAAAATACTTCCTCTGGGCTGCGCATGGTGGCT
CACACCTATAATCCCAGCACTTTGGGAGGCCAAGCTTGGTGGATCGCTTGAGCCCAGCGGTTTAAGATCAGTCTGGGCAATATGGTGACA
CCCCATCTCTACAAAAAATTAGCCAGTTGTGGTGGCCCAAGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCCGTAGGATCCCTTGAGC
CCAGGAGTTCGAGGCTGCAGCGAGCCGAGATTGCGCTACTGAACTCCAGCCTGGGTTACAGAGCGAGACCCTGTCTCAAAGAAACAAACA
AACAAACAAACAAACAAACAAAACTTTCTTTGGATGCGGCTGCGGCATGGATTTGAAATCACGTGGGCAGGCCCTGTTCTGGGGCCCCAC
CACATGTGCAGGACAAGCCCAGGGGAGCTCCCAGCCGGCATCCCCACGCCCCCAGCCCAGCCTGCTCCAAACAGACCCCCCACCCACCTC
CACAGCCAGGATGTCAGCAGGGCCTGAGCCAGGCTCGTCCCCTGTGGGGAGAGCCACAGGGCCAGGTGGACACGCCGACGGGCGATGAGG
ATCCTGGCTGGGCCTCCCCCGGGAACAGCTGTGCTGGACAGTCAGACCCGGAGCCCAGAGGCACCCCCACCCACCCCCCGCCCCGAGCCC
TGTACCACTGAGTGCCTTTCACAGAGAAAACCCACTCTGCCATGTGTCACTGAGGCCTGGATTTGAGCTTCCGTCCTTCCTTCCTCCCTC
TCTCCCTGATGTAGGCCTTGGCTGGCCCTGAGGCAGGGGGTCCCCAATCCCCCCTTGTGGTAGCAGGGCCCGGGACCCGTGCCTGGGGGA
CCCGGGGAGGGGCCGCCGTCTTGTGGATGCTGGCCATGGTGGGCAGGCGCCTCCTGGCACTGATGGATGTGGGGGCACCCCCTTCTGAGT
CCCCACCCCAACCTGTTCAAACCTTCCGCTTGGTCAGTTTTTTTTTCTTTGGCCAGCTGCCCAGTGGCATTGAATGAGAAAAGTCCACCT
TTGGGCAGATGTGATCTCCAGCCAGTGGCTCAGTTTTGTTTCTCTGTGTTTGAAGGACAGCCTGCATGTGGCTCTGTCTGAATGTCTTTG

>65129_65129_1_PIAS4-ZFR2_PIAS4_chr19_4013347_ENST00000262971_ZFR2_chr19_3823401_ENST00000262961_length(amino acids)=690AA_BP=155
MVTKMAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKNSEPAPQPHRPLDPLTM
HSTYDRAGAVPRTPLAGPNIDYPVLYGKYLNGLGRLPAKTLKPEVRLVKLPFFNMLDELLKPTELGPPEPQAAGCRPQWGKPAQPKLEGP
GAPTQGGSKEAPAGCSDAQPVGPEYVEEVFSDEGRVLRFHCKLCECSFNDLNAKDLHVRGRRHRLQYRKKVNPDLPIATEPSSRARKVLE
ERMRKQRHLAEERLEQLRRWHAERRRLEEEPPQDVPPHAPPDWAQPLLMGRPESPASAPLQPGRRPASSDDRHVMCKHATIYPTEQELLA
VQRAVSHAERALKLVSDTLAEEDRGRREEEGDKRSSVAPQTRVLKGVMRVGILAKGLLLRGDRNVRLALLCSEKPTHSLLRRIAQQLPRQ
LQMVTEDEYEVSSDPEANIVISSCEEPRMQVTISVTSPLMREDPSTDPGVEEPQADAGDVLSPKKCLESLAALRHARWFQARASGLQPCV
IVIRVLRDLCRRVPTWGALPAWAMELLVEKAVSSAAGPLGPGDAVRRVLECVATGTLLTDGPGLQDPCERDQTDALEPMTLQEREDVTAS

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Fusion Gene PPI Analysis for PIAS4-ZFR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PIAS4-ZFR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PIAS4-ZFR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource