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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PICK1-EIF4ENIF1 (FusionGDB2 ID:65169)

Fusion Gene Summary for PICK1-EIF4ENIF1

Fusion gene summary

Fusion gene information	Fusion gene name: PICK1-EIF4ENIF1
	Fusion gene ID: 65169
		Hgene	Tgene
	Gene symbol	PICK1	EIF4ENIF1
	Gene ID	9463	56478
	Gene name	protein interacting with PRKCA 1	eukaryotic translation initiation factor 4E nuclear import factor 1
	Synonyms	PICK\|PRKCABP	4E-T\|Clast4
	Cytomap	22q13.1	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	PRKCA-binding proteinprotein interacting with C kinase 1protein kinase C-alpha-binding protein	eukaryotic translation initiation factor 4E transporter2610509L04Rik4E-transportereIF4E transporter
	Modification date	20200313	20200327
	UniProtAcc	.	Q9NRA8
	Ensembl transtripts involved in fusion gene	ENST00000468288, ENST00000356976, ENST00000404072,	ENST00000330125, ENST00000344710, ENST00000382180, ENST00000397523, ENST00000397525, ENST00000441289,
Fusion gene scores	* DoF score	10 X 9 X 9=810	10 X 7 X 9=630
	# samples	11	11
	** MAII score	log2(11/810*10)=-2.88041838424733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PICK1 [Title/Abstract] AND EIF4ENIF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PICK1(38461137)-EIF4ENIF1(31851973), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PICK1	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	10623590
Hgene	PICK1	GO:0015844	monoamine transport	11343649

Fusion gene breakpoints across PICK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EIF4ENIF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-7821-01A	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-

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Fusion Gene ORF analysis for PICK1-EIF4ENIF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000468288	ENST00000330125	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
3UTR-3CDS	ENST00000468288	ENST00000344710	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
3UTR-3CDS	ENST00000468288	ENST00000382180	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
3UTR-3CDS	ENST00000468288	ENST00000397523	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
3UTR-3CDS	ENST00000468288	ENST00000397525	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
3UTR-intron	ENST00000468288	ENST00000441289	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
5CDS-intron	ENST00000356976	ENST00000441289	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
5CDS-intron	ENST00000404072	ENST00000441289	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000356976	ENST00000330125	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000356976	ENST00000344710	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000356976	ENST00000382180	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000356976	ENST00000397523	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000356976	ENST00000397525	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000404072	ENST00000330125	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000404072	ENST00000344710	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000404072	ENST00000382180	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000404072	ENST00000397523	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-
In-frame	ENST00000404072	ENST00000397525	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000404072	PICK1	chr22	38461137	-	ENST00000344710	EIF4ENIF1	chr22	31851973	-	3108	629	347	2590	747
ENST00000404072	PICK1	chr22	38461137	-	ENST00000397525	EIF4ENIF1	chr22	31851973	-	3137	629	347	2623	758
ENST00000404072	PICK1	chr22	38461137	-	ENST00000330125	EIF4ENIF1	chr22	31851973	-	3135	629	347	2623	758
ENST00000404072	PICK1	chr22	38461137	-	ENST00000397523	EIF4ENIF1	chr22	31851973	-	3059	629	347	2551	734
ENST00000404072	PICK1	chr22	38461137	-	ENST00000382180	EIF4ENIF1	chr22	31851973	-	2770	629	1869	2552	227
ENST00000356976	PICK1	chr22	38461137	-	ENST00000344710	EIF4ENIF1	chr22	31851973	-	2999	520	133	2481	782
ENST00000356976	PICK1	chr22	38461137	-	ENST00000397525	EIF4ENIF1	chr22	31851973	-	3028	520	133	2514	793
ENST00000356976	PICK1	chr22	38461137	-	ENST00000330125	EIF4ENIF1	chr22	31851973	-	3026	520	133	2514	793
ENST00000356976	PICK1	chr22	38461137	-	ENST00000397523	EIF4ENIF1	chr22	31851973	-	2950	520	133	2442	769
ENST00000356976	PICK1	chr22	38461137	-	ENST00000382180	EIF4ENIF1	chr22	31851973	-	2661	520	1760	2443	227

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000404072	ENST00000344710	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.003301617	0.9966983
ENST00000404072	ENST00000397525	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.002787109	0.99721295
ENST00000404072	ENST00000330125	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.002749509	0.9972505
ENST00000404072	ENST00000397523	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.003421068	0.9965789
ENST00000404072	ENST00000382180	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.08340673	0.9165932
ENST00000356976	ENST00000344710	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.004267266	0.9957327
ENST00000356976	ENST00000397525	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.003586514	0.9964135
ENST00000356976	ENST00000330125	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.003541261	0.9964587
ENST00000356976	ENST00000397523	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.004373595	0.99562633
ENST00000356976	ENST00000382180	PICK1	chr22	38461137	-	EIF4ENIF1	chr22	31851973	-	0.08995493	0.9100451

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Fusion Genomic Features for PICK1-EIF4ENIF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PICK1-EIF4ENIF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:38461137/chr22:31851973)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	EIF4ENIF1 Q9NRA8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250\|UniProtKB:Q9EST3, ECO:0000269\|PubMed:10856257, ECO:0000269\|PubMed:16157702, ECO:0000269\|PubMed:22966201, ECO:0000269\|PubMed:24335285, ECO:0000269\|PubMed:27342281, ECO:0000269\|PubMed:28216671, ECO:0000269\|PubMed:28487484, ECO:0000269\|PubMed:32354837}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000330125

438_447

321

986.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000330125

613_638

321

986.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000344710

195_211

158

812.0

Motif

Nuclear localization signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000344710

438_447

158

812.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000344710

613_638

158

812.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000397525

438_447

321

986.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000397525

613_638

321

986.0

Motif

Nuclear export signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000330125

664_693

321

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000330125

707_803

321

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000330125

922_953

321

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000344710

664_693

158

812.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000344710

707_803

158

812.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000344710

922_953

158

812.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000397525

664_693

321

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000397525

707_803

321

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000397525

922_953

321

986.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PICK1

chr22:38461137

chr22:31851973

ENST00000356976

382_388

416.0

Compositional bias

Note=Poly-Glu

Hgene

PICK1

chr22:38461137

chr22:31851973

ENST00000404072

382_388

416.0

Compositional bias

Note=Poly-Glu

Hgene

PICK1

chr22:38461137

chr22:31851973

ENST00000356976

144_357

416.0

Domain

Hgene

PICK1

chr22:38461137

chr22:31851973

ENST00000356976

22_105

416.0

Domain

PDZ

Hgene

PICK1

chr22:38461137

chr22:31851973

ENST00000404072

144_357

416.0

Domain

Hgene

PICK1

chr22:38461137

chr22:31851973

ENST00000404072

22_105

416.0

Domain

PDZ

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000330125

148_210

321

986.0

Compositional bias

Note=Arg-rich

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000344710

148_210

158

812.0

Compositional bias

Note=Arg-rich

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000397525

148_210

321

986.0

Compositional bias

Note=Arg-rich

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000330125

195_211

321

986.0

Motif

Nuclear localization signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000397525

195_211

321

986.0

Motif

Nuclear localization signal

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000330125

1_24

321

986.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000344710

1_24

158

812.0

Region

Disordered

Tgene

EIF4ENIF1

chr22:38461137

chr22:31851973

ENST00000397525

1_24

321

986.0

Region

Disordered

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Fusion Gene Sequence for PICK1-EIF4ENIF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>65169_65169_1_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000330125_length(transcript)=3026nt_BP=520nt
AATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGGCTGTGGGACCAACGCTTCCGGTGAGCG
ACAGAGGCAGCTCCCCAGGGCCTGGAGACCCGTGGGGCGGACTCTGGGATCTGAGCCTATCGCCCTGGCCTGGAGCCCCCCTTTGTACCT
ATTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACTTGGATTATGACATCGAAGA
GGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGATCAGCATTGGAGGAGGGGC
CCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGGCAGCTGGCGATGAGATCAC
CGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGATGATAGAAGATGTTTTGGG
AGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCAGCAGTCTTGGGTCAACACC
ACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATT
GGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGC
AAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTCTGAAGGGCTTGAAGGTTGA
CCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACAATCGACAACTGAAGAAAGA
CGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCAAAGTCAGCCGAAACCTTGA
AAGCCATTTGATGTCCCCTGCTGAGATTCCAGGCCAGCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGGGTCAACCAGTTCAGAGACC
TGCTTCTTCCAATCTTCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTC
ACAGGTGTTTCAAACTCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCACACCAGGACCACAGCAGCT
ACTCGGAGATCCATTCCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGA
AGGGCTGGCCTTGCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGA
TGGATTCAGAAACAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCAT
CACAAGCATGCTTTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATC
TGGAAAAGCAGCTCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGA
TCGAGACTCTTCTCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACAC
CAAAGAACAAGATTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGT
CCACCAAGTTCCCCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGG
AGTACATCCACAGCATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCC
CATCCTGGGTCAGCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGT
GCAACAGCAGCTACAGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGT
GCCCAGCCGGTCAGGCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATG
GTTTGGCTCAGATGTGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGG
GCAGGCAGACTCAACTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGG
AGCACTCTGTGTGAAGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGT
ACATTGTCTGAATACAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCT
CACCAAGAGGTGGCACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAACAACTTTTGTATATACAT
ATAGGATAGCTTTTTTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGTTTGGATTTTTTTCACTTG

>65169_65169_1_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000330125_length(amino acids)=793AA_BP=129
MGSEPIALAWSPPLYLFPIPLPSWAVSQPTPTLGTMFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDN
TPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAI
LSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHL
EETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLE
PTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAAN
FYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQK
ASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRP
AHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGS

--------------------------------------------------------------
>65169_65169_2_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000344710_length(transcript)=2999nt_BP=520nt
AATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGGCTGTGGGACCAACGCTTCCGGTGAGCG
ACAGAGGCAGCTCCCCAGGGCCTGGAGACCCGTGGGGCGGACTCTGGGATCTGAGCCTATCGCCCTGGCCTGGAGCCCCCCTTTGTACCT
ATTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACTTGGATTATGACATCGAAGA
GGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGATCAGCATTGGAGGAGGGGC
CCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGGCAGCTGGCGATGAGATCAC
CGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGATGATAGAAGATGTTTTGGG
AGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCAGCAGTCTTGGGTCAACACC
ACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATT
GGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGC
AAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTCTGAAGGGCTTGAAGGTTGA
CCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACAATCGACAACTGAAGAAAGA
CGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGCGAAACCTTGAAAGCCATTTGATGTCCCCTGCTGAGATTCCAGGCCA
GCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGGGTCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTCTGAGTGGCCTTATGGGGAG
CTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTCGAGCAGCCTCAGCTGACTA
CCTTCGCCCAAGAATACCATCACCAATTGGTTTCACACCAGGACCACAGCAGCTACTCGGAGATCCATTCCAAGGCATGCGCAAACCCAT
GAGCCCCATCACAGCCCAGCAGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGTACA
GGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAACAGGCAACAGCGAGTGACCAA
GTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCATCACAAGCATGCTTTCTCCTTCCTTTACCCCTAC
CTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGAGGA
TACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAAACT
GTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAACTGG
GAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCCTAT
GGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCTCCA
AACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTACCTGC
TGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGTTCTGCATCC
TCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCACATGCACTC
CCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCAACCCCTGCC
CTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGGACCTGTGGT
GGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGGTGGAACCCA
TGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCACAATGTTGTC
AATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCTCACCAAGAGGTGGCACCTAAGGGTTCTGAGGAA
ATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAACAACTTTTGTATATACATATAGGATAGCTTTTTTGAACTATACAGCTGTAC
ATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGTTTGGATTTTTTTCACTTGTACATTTGGGATTTTCTTTTGGTTGATTAAAAT

>65169_65169_2_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000344710_length(amino acids)=782AA_BP=129
MGSEPIALAWSPPLYLFPIPLPSWAVSQPTPTLGTMFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDN
TPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAI
LSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHL
EETLSAVTNNRQLKKDGDMTAFNKLVSTMKRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPS
PPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQV
DRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSS
VPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQR
MLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQT

--------------------------------------------------------------
>65169_65169_3_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000382180_length(transcript)=2661nt_BP=520nt
AATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGGCTGTGGGACCAACGCTTCCGGTGAGCG
ACAGAGGCAGCTCCCCAGGGCCTGGAGACCCGTGGGGCGGACTCTGGGATCTGAGCCTATCGCCCTGGCCTGGAGCCCCCCTTTGTACCT
ATTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACTTGGATTATGACATCGAAGA
GGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGATCAGCATTGGAGGAGGGGC
CCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGGCAGCTGGCGATGAGATCAC
CGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGTTCTGCATCCTCCAGGCTCT
GGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCACATGCACTCCCAGCTGGAG
CATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCAACCCCTGCCCTCCATGCCC
GCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGGACCTGTGGTGGCACACTGG
GCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGGTGGAACCCATGCATCTGGT
GTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCACAATGTTGTCGTGTGCTTCC
TCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCT
CTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGAAAACCTCCTGTCATCCAGCTCTGT
ACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGC
CAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTT
TCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGAT
GCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCTCCAAACTGCTTTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGA
TGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTG
AAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCATCACAAGCATGAT
GAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGG
TTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAACAGGTTTCACACCAGGACCACAGCAGCTACTCGGAGATCCATTCC
AAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGGAACTTCTGGGTCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTCTGAGTG
GCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTCGAGCAG
CCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTCTGA
AGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACAATC
GACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCAAAG
TCAGCGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAA
AGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGA
AAGCTATGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCC

>65169_65169_3_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000382180_length(amino acids)=227AA_BP=
MTLLYRQQTSTSLVLANHRWTEPEMDSETGFTPGPQQLLGDPFQGMRKPMSPITAQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRA
PSPPLSQVFQTRAASADYLRPRIPSPIAHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVS

--------------------------------------------------------------
>65169_65169_4_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000397523_length(transcript)=2950nt_BP=520nt
AATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGGCTGTGGGACCAACGCTTCCGGTGAGCG
ACAGAGGCAGCTCCCCAGGGCCTGGAGACCCGTGGGGCGGACTCTGGGATCTGAGCCTATCGCCCTGGCCTGGAGCCCCCCTTTGTACCT
ATTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACTTGGATTATGACATCGAAGA
GGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGATCAGCATTGGAGGAGGGGC
CCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGGCAGCTGGCGATGAGATCAC
CGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGATGATAGAAGATGTTTTGGG
AGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCAGCAGTCTTGGGTCAACACC
ACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATT
GGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGC
AAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTCTGAAGGGCTTGAAGGTTGA
CCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACAATCGACAACTGAAGAAAGA
CGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCAAAGTCAGCGAACTTCTGGG
TCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGC
ACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCAC
ACCAGGACCACAGCAGCTACTCGGAGATCCATTCCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGATGAGCCAGCTGGAGTT
GCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACA
GGTGGACAGAACCAGAGATGGATTCAGAAACAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCC
TGCCCCTGCTGCCTCCATCACAAGCATGCTTTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAG
CAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAG
CTCTGTACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTC
CCAGGCCAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAAC
ACCTTTTCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACA
GAGGATGCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTT
ACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACC
TCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCA
GACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCC
TGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGA
ATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTT
TATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTA
ACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGA
ATGAAGTGTTGGTGTCCTCACCAAGAGGTGGCACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAA
CAACTTTTGTATATACATATAGGATAGCTTTTTTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGT

>65169_65169_4_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000397523_length(amino acids)=769AA_BP=129
MGSEPIALAWSPPLYLFPIPLPSWAVSQPTPTLGTMFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDN
TPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAI
LSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHL
EETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAA
SADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQR
VTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTN
SKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPS
LLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPH

--------------------------------------------------------------
>65169_65169_5_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000397525_length(transcript)=3028nt_BP=520nt
AATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGGCTGTGGGACCAACGCTTCCGGTGAGCG
ACAGAGGCAGCTCCCCAGGGCCTGGAGACCCGTGGGGCGGACTCTGGGATCTGAGCCTATCGCCCTGGCCTGGAGCCCCCCTTTGTACCT
ATTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACTTGGATTATGACATCGAAGA
GGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGATCAGCATTGGAGGAGGGGC
CCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGGCAGCTGGCGATGAGATCAC
CGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGATGATAGAAGATGTTTTGGG
AGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCAGCAGTCTTGGGTCAACACC
ACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATT
GGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGC
AAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTCTGAAGGGCTTGAAGGTTGA
CCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACAATCGACAACTGAAGAAAGA
CGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCAAAGTCAGCCGAAACCTTGA
AAGCCATTTGATGTCCCCTGCTGAGATTCCAGGCCAGCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGGGTCAACCAGTTCAGAGACC
TGCTTCTTCCAATCTTCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTC
ACAGGTGTTTCAAACTCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCACACCAGGACCACAGCAGCT
ACTCGGAGATCCATTCCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGA
AGGGCTGGCCTTGCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGA
TGGATTCAGAAACAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCAT
CACAAGCATGCTTTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATC
TGGAAAAGCAGCTCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGA
TCGAGACTCTTCTCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACAC
CAAAGAACAAGATTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGT
CCACCAAGTTCCCCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGG
AGTACATCCACAGCATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCC
CATCCTGGGTCAGCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGT
GCAACAGCAGCTACAGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGT
GCCCAGCCGGTCAGGCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATG
GTTTGGCTCAGATGTGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGG
GCAGGCAGACTCAACTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGG
AGCACTCTGTGTGAAGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGT
ACATTGTCTGAATACAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCT
CACCAAGAGGTGGCACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAACAACTTTTGTATATACAT
ATAGGATAGCTTTTTTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGTTTGGATTTTTTTCACTTG

>65169_65169_5_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000356976_EIF4ENIF1_chr22_31851973_ENST00000397525_length(amino acids)=793AA_BP=129
MGSEPIALAWSPPLYLFPIPLPSWAVSQPTPTLGTMFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDN
TPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAI
LSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHL
EETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLE
PTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAAN
FYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQK
ASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRP
AHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGS

--------------------------------------------------------------
>65169_65169_6_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000330125_length(transcript)=3135nt_BP=629nt
GGCGGGGTTAGACGCTGTCAGCCTGTCCAGACCGTTCCTCTGTTTTCGCTTGTTCCTACTAACAGCGAGCTTCCGCCAATACTTGTTCTC
GTTCTTGGTTCCGAGCGTCCCGGGAGCCGGGAAGGGAAGGATTGTCTGCAGGGATTGGAGCAAATATCCAGTGGGGGGAAAGCCGGGACT
TCCGCGTCTTGCCGGAAGTGACGTGACAATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGG
CTGTGGGACCAACGCTTCCGTTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACT
TGGATTATGACATCGAAGAGGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGA
TCAGCATTGGAGGAGGGGCCCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGG
CAGCTGGCGATGAGATCACCGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGA
TGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCA
GCAGTCTTGGGTCAACACCACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATT
ACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTC
TTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTC
TGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACA
ATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCA
AAGTCAGCCGAAACCTTGAAAGCCATTTGATGTCCCCTGCTGAGATTCCAGGCCAGCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGG
GTCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAG
CACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCA
CACCAGGACCACAGCAGCTACTCGGAGATCCATTCCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGATGAGCCAGCTGGAGT
TGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCAC
AGGTGGACAGAACCAGAGATGGATTCAGAAACAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCC
CTGCCCCTGCTGCCTCCATCACAAGCATGCTTTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAA
GCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCA
GCTCTGTACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGT
CCCAGGCCAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAA
CACCTTTTCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTAC
AGAGGATGCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATT
TACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACAC
CTCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTC
AGACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCC
CTGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGG
AATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGT
TTATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTT
AACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTG
AATGAAGTGTTGGTGTCCTCACCAAGAGGTGGCACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAA
ACAACTTTTGTATATACATATAGGATAGCTTTTTTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAG

>65169_65169_6_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000330125_length(amino acids)=758AA_BP=94
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMI
QEVKMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKV
DLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTL
PSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPS
PIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRG
NSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSC
STPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGM
DLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQ

--------------------------------------------------------------
>65169_65169_7_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000344710_length(transcript)=3108nt_BP=629nt
GGCGGGGTTAGACGCTGTCAGCCTGTCCAGACCGTTCCTCTGTTTTCGCTTGTTCCTACTAACAGCGAGCTTCCGCCAATACTTGTTCTC
GTTCTTGGTTCCGAGCGTCCCGGGAGCCGGGAAGGGAAGGATTGTCTGCAGGGATTGGAGCAAATATCCAGTGGGGGGAAAGCCGGGACT
TCCGCGTCTTGCCGGAAGTGACGTGACAATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGG
CTGTGGGACCAACGCTTCCGTTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACT
TGGATTATGACATCGAAGAGGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGA
TCAGCATTGGAGGAGGGGCCCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGG
CAGCTGGCGATGAGATCACCGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGA
TGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCA
GCAGTCTTGGGTCAACACCACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATT
ACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTC
TTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTC
TGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACA
ATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGCGAAACCTTGAAAGCCATTTGATGTCCC
CTGCTGAGATTCCAGGCCAGCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGGGTCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTC
TGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTC
GAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCACACCAGGACCACAGCAGCTACTCGGAGATCCATTCC
AAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGCAGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGC
CACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAACA
GGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCATCACAAGCATGCTTT
CTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTC
TTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGATCGAGACTCTTCTC
CCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACACCAAAGAACAAGATT
ATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGTCCACCAAGTTCCCC
TTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGGAGTACATCCACAGC
ATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCAGC
CCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCTAC
AGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTCAG
GCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGATG
TGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTCAA
CTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGTGA
AGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAATA
CAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCTCACCAAGAGGTGGC
ACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAAACAACTTTTGTATATACATATAGGATAGCTTTT
TTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAGTTTGGATTTTTTTCACTTGTACATTTGGGATTT

>65169_65169_7_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000344710_length(amino acids)=747AA_BP=94
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMI
QEVKMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKV
DLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKRNLES
HLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLL
GDPFQGMRKPMSPITAQQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASI
TSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYT
KEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGP
ILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKW

--------------------------------------------------------------
>65169_65169_8_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000382180_length(transcript)=2770nt_BP=629nt
GGCGGGGTTAGACGCTGTCAGCCTGTCCAGACCGTTCCTCTGTTTTCGCTTGTTCCTACTAACAGCGAGCTTCCGCCAATACTTGTTCTC
GTTCTTGGTTCCGAGCGTCCCGGGAGCCGGGAAGGGAAGGATTGTCTGCAGGGATTGGAGCAAATATCCAGTGGGGGGAAAGCCGGGACT
TCCGCGTCTTGCCGGAAGTGACGTGACAATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGG
CTGTGGGACCAACGCTTCCGTTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACT
TGGATTATGACATCGAAGAGGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGA
TCAGCATTGGAGGAGGGGCCCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGG
CAGCTGGCGATGAGATCACCGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGT
TCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCA
CATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCA
ACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGG
ACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGG
TGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCAC
AATGTTGTCGTGTGCTTCCTCCTGGGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTAC
CTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGAAAACC
TCCTGTCATCCAGCTCTGTACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTT
CCACCCCACTGTCCCAGGCCAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCC
CAGTTCCTACAACACCTTTTCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACC
CAGGGTTGGTACAGAGGATGCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCTCCAAACTGCTTTCTCCTTCCTTTACCCCT
ACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGAG
GATACTCAGAAGGCCAGTGAAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCCCTGCCCCTGCTG
CCTCCATCACAAGCATGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGTACAGGCAG
CAAACTTCTACCAGCCTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAACAGGTTTCACACCAGGACCACAGCAG
CTACTCGGAGATCCATTCCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGGAACTTCTGGGTCAACCAGTTCAGAGACCTGCT
TCTTCCAATCTTCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAG
GTGTTTCAAACTCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGCACATTCAGGGGTTGTGCTTTCAGTGGAG
GAGGTAGAAGCAGGTCTGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTG
AGTGCCGTAACCAACAATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGGCAAGTGGGACT
TTGCCTTCTCAGCCCAAAGTCAGCGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATTACTTTGCTCCTATACCATTGG
AAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTCTTCTTTCCAGCCTTTCTGCAA
ATAAAGAAAAACTTAAAGAAAGCTATGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAAC

>65169_65169_8_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000382180_length(amino acids)=227AA_BP=
MTLLYRQQTSTSLVLANHRWTEPEMDSETGFTPGPQQLLGDPFQGMRKPMSPITAQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRA
PSPPLSQVFQTRAASADYLRPRIPSPIAHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVS

--------------------------------------------------------------
>65169_65169_9_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000397523_length(transcript)=3059nt_BP=629nt
GGCGGGGTTAGACGCTGTCAGCCTGTCCAGACCGTTCCTCTGTTTTCGCTTGTTCCTACTAACAGCGAGCTTCCGCCAATACTTGTTCTC
GTTCTTGGTTCCGAGCGTCCCGGGAGCCGGGAAGGGAAGGATTGTCTGCAGGGATTGGAGCAAATATCCAGTGGGGGGAAAGCCGGGACT
TCCGCGTCTTGCCGGAAGTGACGTGACAATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGG
CTGTGGGACCAACGCTTCCGTTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACT
TGGATTATGACATCGAAGAGGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGA
TCAGCATTGGAGGAGGGGCCCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGG
CAGCTGGCGATGAGATCACCGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGA
TGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCA
GCAGTCTTGGGTCAACACCACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATT
ACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTC
TTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTC
TGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACA
ATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCA
AAGTCAGCGAACTTCTGGGTCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACAT
CTTTACTGGGCCAAAGAGCACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATAC
CATCACCAATTGGTTTCACACCAGGACCACAGCAGCTACTCGGAGATCCATTCCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCC
AGATGAGCCAGCTGGAGTTGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGC
CTGGTTTTGGCAAACCACAGGTGGACAGAACCAGAGATGGATTCAGAAACAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATC
GAGGGAATTCCTCTTCCCCTGCCCCTGCTGCCTCCATCACAAGCATGCTTTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGT
ACGAGAGCAAAGAGAAAAGCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAG
AAAACCTCCTGTCATCCAGCTCTGTACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTT
CGTGTTCCACCCCACTGTCCCAGGCCAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGG
CATCCCCAGTTCCTACAACACCTTTTCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGC
TTCACCCAGGGTTGGTACAGAGGATGCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTG
GGATGGACTTGAGTCATTTACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAA
ACCCTCGTCCTGGAACACCTCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATG
CAGCAGCTGTCAGCGTTCAGACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCA
GCCAGAGGAGCAGCTCCCCTGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTA
TCAGTGTAGATGAATTGGAATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCT
GCTTCATCTCGGGTTGGTTTATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCA
TTATGATGGAAGGATCTTAACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTC
TTTTTTGTAAGATATGTGAATGAAGTGTTGGTGTCCTCACCAAGAGGTGGCACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTAT
GTACAGACCTGTGTATAAACAACTTTTGTATATACATATAGGATAGCTTTTTTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAG

>65169_65169_9_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000397523_length(amino acids)=734AA_BP=94
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMI
QEVKMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKV
DLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTL
PSQPKVSELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMS
PITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSV
IRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRK
TPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAAS
HPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDVLQQPLPSM

--------------------------------------------------------------
>65169_65169_10_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000397525_length(transcript)=3137nt_BP=629nt
GGCGGGGTTAGACGCTGTCAGCCTGTCCAGACCGTTCCTCTGTTTTCGCTTGTTCCTACTAACAGCGAGCTTCCGCCAATACTTGTTCTC
GTTCTTGGTTCCGAGCGTCCCGGGAGCCGGGAAGGGAAGGATTGTCTGCAGGGATTGGAGCAAATATCCAGTGGGGGGAAAGCCGGGACT
TCCGCGTCTTGCCGGAAGTGACGTGACAATCGCGGCCACCGCCAGGTGGAACGGCAGGTGGGTTCAGGTACCAGCCTGGCCGGGACCCGG
CTGTGGGACCAACGCTTCCGTTCCCCATTCCCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACTCTCGGAACCATGTTTGCAGACT
TGGATTATGACATCGAAGAGGATAAACTCGGAATCCCGACTGTGCCTGGGAAGGTGACCCTGCAGAAGGATGCTCAGAACCTGATCGGGA
TCAGCATTGGAGGAGGGGCCCAGTACTGTCCCTGCCTCTATATCGTCCAGGTATTTGACAACACCCCAGCAGCCTTGGACGGCACAGTGG
CAGCTGGCGATGAGATCACCGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGGAGGTGGCGAAGATGATTCAGGAGGTGAAGA
TGATAGAAGATGTTTTGGGAGAAGGGTCAGTCTCTGCCAGTCGGTTCAGTAGGTGGTTCTCTAACCCGAGCAGATCAGGAAGCCGATCCA
GCAGTCTTGGGTCAACACCACATGAAGAGCTAGAGAGACTTGCAGGTCTGGAGCAAGCCATCCTCTCTCCTGGACAGAACTCGGGGAATT
ACTTTGCTCCTATACCATTGGAAGACCATGCTGAAAATAAAGTGGATATTTTAGAAATGCTACAGAAAGCCAAAGTGGATTTGAAACCTC
TTCTTTCCAGCCTTTCTGCAAATAAAGAAAAACTTAAAGAAAGCTCACATTCAGGGGTTGTGCTTTCAGTGGAGGAGGTAGAAGCAGGTC
TGAAGGGCTTGAAGGTTGACCAGCAAGTGAAGAATTCAACTCCCTTCATGGCAGAACACCTAGAAGAGACCTTGAGTGCCGTAACCAACA
ATCGACAACTGAAGAAAGACGGAGACATGACTGCGTTCAACAAGCTAGTGAGCACAATGAAGGCAAGTGGGACTTTGCCTTCTCAGCCCA
AAGTCAGCCGAAACCTTGAAAGCCATTTGATGTCCCCTGCTGAGATTCCAGGCCAGCCTGTCCCTAAGAACATCCTGCAGGAACTTCTGG
GTCAACCAGTTCAGAGACCTGCTTCTTCCAATCTTCTGAGTGGCCTTATGGGGAGCTTGGAGCCTACAACATCTTTACTGGGCCAAAGAG
CACCCTCTCCTCCCTTGTCACAGGTGTTTCAAACTCGAGCAGCCTCAGCTGACTACCTTCGCCCAAGAATACCATCACCAATTGGTTTCA
CACCAGGACCACAGCAGCTACTCGGAGATCCATTCCAAGGCATGCGCAAACCCATGAGCCCCATCACAGCCCAGATGAGCCAGCTGGAGT
TGCAACAGGCAGCTTTAGAAGGGCTGGCCTTGCCACATGACCTTGCTGTACAGGCAGCAAACTTCTACCAGCCTGGTTTTGGCAAACCAC
AGGTGGACAGAACCAGAGATGGATTCAGAAACAGGCAACAGCGAGTGACCAAGTCACCAGCACCCGTGCATCGAGGGAATTCCTCTTCCC
CTGCCCCTGCTGCCTCCATCACAAGCATGCTTTCTCCTTCCTTTACCCCTACCTCAGTGATTCGTAAGATGTACGAGAGCAAAGAGAAAA
GCAAGGAGGAGCCAGCATCTGGAAAAGCAGCTCTTGGTGACAGTAAAGAGGATACTCAGAAGGCCAGTGAAGAAAACCTCCTGTCATCCA
GCTCTGTACCCAGTGCCGATCGAGACTCTTCTCCCACTACAAATTCCAAACTGTCAGCATTACAGAGGTCTTCGTGTTCCACCCCACTGT
CCCAGGCCAACCGTTACACCAAAGAACAAGATTATCGACCTAAAGCAACTGGGAGAAAAACACCCACCTTGGCATCCCCAGTTCCTACAA
CACCTTTTCTCCGCCCTGTCCACCAAGTTCCCCTTGTCCCCCATGTCCCTATGGTTAGGCCTGCTCACCAGCTTCACCCAGGGTTGGTAC
AGAGGATGCTGGCCCAGGGAGTACATCCACAGCATCTTCCAAGTTTGCTCCAAACTGGTGTGCTTCCTCCTGGGATGGACTTGAGTCATT
TACAGGGAATATCTGGCCCCATCCTGGGTCAGCCCTTTTACCCTTTACCTGCTGCTAGTCACCCTCTCTTAAACCCTCGTCCTGGAACAC
CTCTGCATCTGGCAATGGTGCAACAGCAGCTACAGCGCTCAGTTCTGCATCCTCCAGGCTCTGGTTCCCATGCAGCAGCTGTCAGCGTTC
AGACAACCCCTCAGAACGTGCCCAGCCGGTCAGGCCTGCCCCACATGCACTCCCAGCTGGAGCATCGCCCCAGCCAGAGGAGCAGCTCCC
CTGTGGGCCTTGCCAAATGGTTTGGCTCAGATGTGCTACAGCAACCCCTGCCCTCCATGCCCGCCAAAGTTATCAGTGTAGATGAATTGG
AATACCGACAGTGAGCAGGGCAGGCAGACTCAACTAAGCCCGGACCTGTGGTGGCACACTGGGCAGGACCCTGCTTCATCTCGGGTTGGT
TTATGGGCTTTTACTTTGGAGCACTCTGTGTGAAGCTGTTTGGTGGAACCCATGCATCTGGTGTGGTCCGCATTATGATGGAAGGATCTT
AACCAGTCGAGTGGAGTGTACATTGTCTGAATACAGGATGCACAATGTTGTCAATCCTGGAAATGGTCTTTCTTTTTTGTAAGATATGTG
AATGAAGTGTTGGTGTCCTCACCAAGAGGTGGCACCTAAGGGTTCTGAGGAAATAAATGTATAGACCCTTATGTACAGACCTGTGTATAA
ACAACTTTTGTATATACATATAGGATAGCTTTTTTGAACTATACAGCTGTACATAAAAGTAGCTGATATTAGTTAGGCCTGTGTCAACAG

>65169_65169_10_PICK1-EIF4ENIF1_PICK1_chr22_38461137_ENST00000404072_EIF4ENIF1_chr22_31851973_ENST00000397525_length(amino acids)=758AA_BP=94
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMI
QEVKMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKV
DLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTL
PSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPS
PIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRG
NSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSC
STPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGM
DLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQ

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Fusion Gene PPI Analysis for PICK1-EIF4ENIF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000344710		4	17	219_240	158.0	812.0	DDX6
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000330125		6	19	448_490	321.0	986.0	LSM14A
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000330125		6	19	940_985	321.0	986.0	LSM14A
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000344710		4	17	448_490	158.0	812.0	LSM14A
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000344710		4	17	940_985	158.0	812.0	LSM14A
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000397525		6	19	448_490	321.0	986.0	LSM14A
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000397525		6	19	940_985	321.0	986.0	LSM14A
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000330125		6	19	695_713	321.0	986.0	PATL1
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000344710		4	17	695_713	158.0	812.0	PATL1
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000397525		6	19	695_713	321.0	986.0	PATL1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000330125		6	19	131_161	321.0	986.0	CSDE1
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000344710		4	17	131_161	158.0	812.0	CSDE1
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000397525		6	19	131_161	321.0	986.0	CSDE1
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000330125		6	19	219_240	321.0	986.0	DDX6
Tgene	EIF4ENIF1	chr22:38461137	chr22:31851973	ENST00000397525		6	19	219_240	321.0	986.0	DDX6

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PICK1-EIF4ENIF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PICK1-EIF4ENIF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source