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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PID1-CHMP3 (FusionGDB2 ID:65181)

Fusion Gene Summary for PID1-CHMP3

check button Fusion gene summary
Fusion gene informationFusion gene name: PID1-CHMP3
Fusion gene ID: 65181
HgeneTgene
Gene symbol

PID1

CHMP3

Gene ID

55022

100526767

Gene namephosphotyrosine interaction domain containing 1RNF103-CHMP3 readthrough
SynonymsHMFN2073|NYGGF4|P-CLI1|PCLI1CGI149|CHMP3|NEDF|RNF103-VPS24|VPS24|hVps24
Cytomap

2q36.3

2p11.2

Type of geneprotein-codingprotein-coding
DescriptionPTB-containing, cubilin and LRP1-interacting proteinphosphotyrosine interaction domain-containing protein 1RNF103-CHMP3 proteinCharged multivesicular body protein 3Chromatin-modifying protein 3Neuroendocrine differentiation factorRNF103-CHMP3 read-throughRNF103-VPS24 readthroughVacuolar protein sorting-associated protein 24
Modification date2020031320200313
UniProtAcc.

Q9Y3E7

Ensembl transtripts involved in fusion geneENST00000354069, ENST00000392054, 
ENST00000392055, ENST00000482518, 
ENST00000409462, 		ENST00000494623, 
ENST00000409225, ENST00000409727, 
ENST00000439940, ENST00000263856, 
Fusion gene scores* DoF score9 X 9 X 4=3245 X 3 X 3=45
# samples 106
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/45*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PID1 [Title/Abstract] AND CHMP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPID1(230020533)-CHMP3(86737602), # samples:1
Anticipated loss of major functional domain due to fusion event.PID1-CHMP3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePID1

GO:0001933

negative regulation of protein phosphorylation

19079291

HgenePID1

GO:0045444

fat cell differentiation

16815647

HgenePID1

GO:0046325

negative regulation of glucose import

19079291

HgenePID1

GO:0046627

negative regulation of insulin receptor signaling pathway

19079291

HgenePID1

GO:0070346

positive regulation of fat cell proliferation

16815647

HgenePID1

GO:1903077

negative regulation of protein localization to plasma membrane

19079291


check buttonFusion gene breakpoints across PID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHMP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6455PID1chr2

230020533

-CHMP3chr2

86737602

-


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Fusion Gene ORF analysis for PID1-CHMP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000354069ENST00000494623PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-5UTRENST00000392054ENST00000494623PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-5UTRENST00000392055ENST00000494623PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000354069ENST00000409225PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000354069ENST00000409727PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000354069ENST00000439940PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000392054ENST00000409225PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000392054ENST00000409727PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000392054ENST00000439940PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000392055ENST00000409225PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000392055ENST00000409727PID1chr2

230020533

-CHMP3chr2

86737602

-
5CDS-intronENST00000392055ENST00000439940PID1chr2

230020533

-CHMP3chr2

86737602

-
5UTR-3CDSENST00000482518ENST00000263856PID1chr2

230020533

-CHMP3chr2

86737602

-
5UTR-5UTRENST00000482518ENST00000494623PID1chr2

230020533

-CHMP3chr2

86737602

-
5UTR-intronENST00000482518ENST00000409225PID1chr2

230020533

-CHMP3chr2

86737602

-
5UTR-intronENST00000482518ENST00000409727PID1chr2

230020533

-CHMP3chr2

86737602

-
5UTR-intronENST00000482518ENST00000439940PID1chr2

230020533

-CHMP3chr2

86737602

-
Frame-shiftENST00000354069ENST00000263856PID1chr2

230020533

-CHMP3chr2

86737602

-
Frame-shiftENST00000392055ENST00000263856PID1chr2

230020533

-CHMP3chr2

86737602

-
In-frameENST00000392054ENST00000263856PID1chr2

230020533

-CHMP3chr2

86737602

-
intron-3CDSENST00000409462ENST00000263856PID1chr2

230020533

-CHMP3chr2

86737602

-
intron-5UTRENST00000409462ENST00000494623PID1chr2

230020533

-CHMP3chr2

86737602

-
intron-intronENST00000409462ENST00000409225PID1chr2

230020533

-CHMP3chr2

86737602

-
intron-intronENST00000409462ENST00000409727PID1chr2

230020533

-CHMP3chr2

86737602

-
intron-intronENST00000409462ENST00000439940PID1chr2

230020533

-CHMP3chr2

86737602

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392054PID1chr2230020533-ENST00000263856CHMP3chr286737602-3366610199654151

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392054ENST00000263856PID1chr2230020533-CHMP3chr286737602-0.489927560.51007247

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Fusion Genomic Features for PID1-CHMP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PID1-CHMP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:230020533/chr2:86737602)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHMP3

Q9Y3E7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:15707591, ECO:0000269|PubMed:16740483, ECO:0000269|PubMed:17331679, ECO:0000269|PubMed:18076377}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHMP3chr2:230020533chr2:86737602ENST0000026385626141_22295223.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP3chr2:230020533chr2:86737602ENST0000040922515141_22229157.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP3chr2:230020533chr2:86737602ENST0000040972706141_2220183.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP3chr2:230020533chr2:86737602ENST000004097270622_540183.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP3chr2:230020533chr2:86737602ENST0000043994048141_222124252.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP3chr2:230020533chr2:86737602ENST0000026385626201_21195223.0MotifNote=MIT-interacting motif
TgeneCHMP3chr2:230020533chr2:86737602ENST0000040922515201_21129157.0MotifNote=MIT-interacting motif
TgeneCHMP3chr2:230020533chr2:86737602ENST0000040972706201_2110183.0MotifNote=MIT-interacting motif
TgeneCHMP3chr2:230020533chr2:86737602ENST0000043994048201_211124252.0MotifNote=MIT-interacting motif
TgeneCHMP3chr2:230020533chr2:86737602ENST000004092251559_6429157.0RegionNote=Important for autoinhibitory function
TgeneCHMP3chr2:230020533chr2:86737602ENST000004097270659_640183.0RegionNote=Important for autoinhibitory function

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePID1chr2:230020533chr2:86737602ENST00000354069-2393_25092251.0DomainPID
HgenePID1chr2:230020533chr2:86737602ENST00000392054-3493_25090249.0DomainPID
HgenePID1chr2:230020533chr2:86737602ENST00000392055-2393_25059218.0DomainPID
HgenePID1chr2:230020533chr2:86737602ENST00000409462-1293_2500169.0DomainPID
TgeneCHMP3chr2:230020533chr2:86737602ENST000002638562622_5495223.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP3chr2:230020533chr2:86737602ENST000004092251522_5429157.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP3chr2:230020533chr2:86737602ENST000004399404822_54124252.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP3chr2:230020533chr2:86737602ENST000002638562659_6495223.0RegionNote=Important for autoinhibitory function
TgeneCHMP3chr2:230020533chr2:86737602ENST000004399404859_64124252.0RegionNote=Important for autoinhibitory function


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Fusion Gene Sequence for PID1-CHMP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65181_65181_1_PID1-CHMP3_PID1_chr2_230020533_ENST00000392054_CHMP3_chr2_86737602_ENST00000263856_length(transcript)=3366nt_BP=610nt
AGGACAGCCGGCGCGCGGCCGTGCCCACAAGTTGCCGGCAGCTGAGCGCCGCGCCTCCTCCTGCTCGCAGCCCCCTACGCCCACCCGGCG
GCGGTGGCCAGCGCCAGGACGCACATCCCGCGGACACCGACCCCAGATGTAAAGCGGGACCCCAGCCCCTCGCCCCCCGGCGCGATCGAC
AGTCTCGCCAGCGTCTCCTCTGCCAAAACCCAGGGCTGGAAGATGTGGCAGCCGGCCACGGAGCGCCTGCAGGAGAGATTTGCAGACACA
GAAGCGGCACAGAGAAGGCCATTGTGAAGATCAAGGCAGAAACCGGAGTTATGGCATCATAAGCCAAGGAATGCCAAGGATTGCTGGCAA
CCACCTGATGTTAGAAGAGTCGAGGACATGTTCTTCTCCAGAGCTTTTGGATGGTGTGTGGCCCTGCCAACCTTTACATTTTGGACTTCC
AGCCTCCGAAATGCACTTTCAGACCATGCTGAAGTCTAAATTGAATGTCTTAACACTGAAAAAGGAACCTCTCCCAGCGGTCATCTTCCA
TGAGCCGGAGGCCATTGAGCTGTGCACGACCACACCGCTGATGAAGACAAGGACTCACAGTGGCTGCAAGCGGTCTTGCGAGTGGCTGGT
TCCCTGCAGAAGAGCACAGAAGTGATGAAGGCCATGCAAAGTCTTGTGAAGATTCCAGAGATTCAGGCCACCATGAGGGAGTTGTCCAAA
GAAATGATGAAGGCTGGGATCATAGAGGAGATGTTAGAGGACACTTTTGAAAGCATGGACGATCAGGAAGAAATGGAGGAAGAAGCAGAA
ATGGAAATTGACAGAATTCTCTTTGAAATTACAGCAGGGGCCTTGGGCAAAGCACCCAGTAAAGTGACTGATGCCCTTCCAGAGCCAGAA
CCTCCAGGAGCGATGGCTGCCTCAGAGGATGAGGAGGAGGAGGAAGAGGCTCTGGAGGCCATGCAGTCCCGGCTGGCCACACTCCGCAGC
TAGGGGCTGCCTACCCCGCTGGGTGTGCACACACTCCTCTCAAGAGCTGCCATTTTATGTGTCTCTTGCACTACACCTCTGTTGTGAGGA
CTACCATTTTGGAGAAGGTTCTGTTTGTCTCTTTTCATTCTCTGCCCAGGTTTTGGGATCGCAAAGGGATTGTTCTTATAAAAGTGGCAT
AAATAAATGCATCATTTTTAGGAGTATAGACAGATATATCTTATTGTGGGGAGGGGAAAGAAATCCATCTGCTCATGAAGCACTTCTGAA
AATATAGGTGATTGCCTGAATGTCGAAGACTCTACTTTTGTCTATAAAACACTATATAAATGAATTTTAATAAATTTTTGCTTTAGCACT
TGGCCCCATTGTAGATTGCCCTGTGCAGTAAACTTTCAAGGTGTCGGCTGCCCCAGATTGCTTCATTTGCTGGGTGTGGAAAGAGTTGCT
ATGGCCAGGCATATGGGATTTGGAAGCTCAGCAGAAGTGACTTCTGCTCTGTGGTTGCTGCTCCCCGGCTTTCACAGACATGGTATGGCA
GCCATTCTTTTATCTATTTAACCAAGAGGATGCTGGGGAATTGTGCTGCTTGTCCTGTTGGCTGGTGGCTGCATTATGTCCTGGGGTGTG
CATGTGGGTCTATTTAGAGCTTCTGTCCCTTCCTTCCCATTGCAAGTTGCACCCAGATGAGACAGCTGTAGTACTAGGTCTCTTTCACCT
CTCATTGCCTGTCCCTGCTTCGAGCTGGTTGTCTTGTGCGTGGGACATGGGCCTTCCTATCTGTGTTTTCTCAAAGTCAGGAGCTGACCA
GGAGCACACTAAGGTGTGGTCATGCATCATAACCAACATTCACTCATCTGGGACATTCTTAAGATACATTTATAAATCATTTCAGCAGTA
GTACTTTGTATGTGTTGAGAGTTTACAGAGCTCTTTGACATACGCGATCTTAGTCTTTACAAATAAGGAAAACAGCTCAGTTTGGGAAGT
ATCAGAGATGGGATTCAAACCCAGATCCTCTGGTCCAAGTTGTATGTGCACTGAACTAATCAGGCAGGAAAAAAGCCCAGCCACTGTCTC
ACAGATTGTTTTTTGTATATTGTAGCAAAATCCTGAAACAATGGGGTCCTTCCAGTCTCATCATACAAAATGGCAATCTTGGCTGGGTGC
GGTGGTTCATGCCTATAATCCCAGTGCTTTACAAGGCTGAGGCAGGAGGCTCTCTTGAGAATAGGAGTTCAAGACCAGCCTGGGCAACAT
AGCAAGATCCTGTCTCTCCAAAAAAAAAAAAAAAAAAAAAAAAAAATTTCATTTTTGAGTCCAGAGGACCCTCCTATTACTCTTGATTTC
ATCTTCAGAGTGTAGTTAAAAAATTATTTTAAATAATTATTTTTTTAAATCAGTTGTAGGTTCACAGCAAAAGTGGACAAAAAGAAATTT
CTCATATATCCCCTGCCCTCACACATGCATAGCCTCCCACCACTATCAGTATCCCACACCAGAGTGGTACATTTGTTACAATCAATAAAC
CTCCATTGACACATCATTATCACCCAAAGTCCATAGTTTACATGAAGATTCACTCTGGTGTTGTACATTGTATGGGCTTAGACAAATGTA
TGATGATATCTACAATTATAGAATCATACAGAATAGTTTCACTGCCCTAAAACTTCTCTATGCTTCACCTGTTCATCCCTTTCTTCCCTA
ATCCCCTGGCAACCACTTTAAAAAAAAAATTAGGTTCAGGGGGTACATGTGCAGGTAAACTCGTGACAAGGGGGTTTGTTATACAGATTA
TTTAGTGACCCAGGTACTAAGCCTAGTACCCAATAGTTACTTTTCTGGTCCTGTCCCTTTTCCCACCCTCCACCCTCAGGTAGGCCCCAG
TATGTTATTCCTTTGTGTCCATGTTATTTCACTCCCACTTGTGAGAACATGGAATATTTGGTTTCCTGTTCCTATGTTAGTTTGTTAAGG
ATAATGGCCTCCAGCCCCATCCATGTTCCTGCAAAGGACATGATCTTTCTTTGGCAACCACTTTTTACTGTCGCCATAGTTCTTCCTTTT
CTAGAATGTCATATTGGAATCATATAGTATGTAGCCTTTTCAGACTGGCTTCTTTCACTTAATAATATGCAATTAAGGTTCCTCCATGTC
ATTTCATGGCTTAATAGTGCATTTATTTTTAGCACTGAATAATACTCCATTGTCTAGATGAATAGTTTATCCATTCACCTATTGAAAGAC
TTCTTGGTGGTTTCCAAGTTTTGGCAATTATGAATAAAGCTGTTGTAAACATCTTTGTGCAGGTTTTTCTATGGGCATGTTTTTAATTCA

>65181_65181_1_PID1-CHMP3_PID1_chr2_230020533_ENST00000392054_CHMP3_chr2_86737602_ENST00000263856_length(amino acids)=151AA_BP=
MPKPRAGRCGSRPRSACRRDLQTQKRHREGHCEDQGRNRSYGIISQGMPRIAGNHLMLEESRTCSSPELLDGVWPCQPLHFGLPASEMHF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PID1-CHMP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCHMP3chr2:230020533chr2:86737602ENST0000026385626203_20795.33333333333333223.0STAMBP
TgeneCHMP3chr2:230020533chr2:86737602ENST0000040922515203_20729.333333333333332157.0STAMBP
TgeneCHMP3chr2:230020533chr2:86737602ENST0000040972706203_2070183.0STAMBP
TgeneCHMP3chr2:230020533chr2:86737602ENST0000043994048203_207124.33333333333333252.0STAMBP
TgeneCHMP3chr2:230020533chr2:86737602ENST0000026385626151_22295.33333333333333223.0VPS4A
TgeneCHMP3chr2:230020533chr2:86737602ENST0000040922515151_22229.333333333333332157.0VPS4A
TgeneCHMP3chr2:230020533chr2:86737602ENST0000040972706151_2220183.0VPS4A
TgeneCHMP3chr2:230020533chr2:86737602ENST0000043994048151_222124.33333333333333252.0VPS4A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PID1-CHMP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PID1-CHMP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource