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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PID1-DNER (FusionGDB2 ID:65182)

Fusion Gene Summary for PID1-DNER

Fusion gene summary

Fusion gene information	Fusion gene name: PID1-DNER
	Fusion gene ID: 65182
		Hgene	Tgene
	Gene symbol	PID1	DNER
	Gene ID	55022	92737
	Gene name	phosphotyrosine interaction domain containing 1	delta/notch like EGF repeat containing
	Synonyms	HMFN2073\|NYGGF4\|P-CLI1\|PCLI1	UNQ26\|bet
	Cytomap	2q36.3	2q36.3
	Type of gene	protein-coding	protein-coding
	Description	PTB-containing, cubilin and LRP1-interacting proteinphosphotyrosine interaction domain-containing protein 1	delta and Notch-like epidermal growth factor-related receptorH_NH0150O02.1WUGSC:H_NH0150O02.1delta-notch-like EGF repeat-containing transmembrane
	Modification date	20200313	20200313
	UniProtAcc	.	Q8NFT8
	Ensembl transtripts involved in fusion gene	ENST00000354069, ENST00000392054, ENST00000392055, ENST00000482518, ENST00000409462,	ENST00000482831, ENST00000341772,
Fusion gene scores	* DoF score	9 X 9 X 4=324	5 X 3 X 4=60
	# samples	10	7
	** MAII score	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PID1 [Title/Abstract] AND DNER [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PID1(230020534)-DNER(230456604), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PID1	GO:0001933	negative regulation of protein phosphorylation	19079291
Hgene	PID1	GO:0045444	fat cell differentiation	16815647
Hgene	PID1	GO:0046325	negative regulation of glucose import	19079291
Hgene	PID1	GO:0046627	negative regulation of insulin receptor signaling pathway	19079291
Hgene	PID1	GO:0070346	positive regulation of fat cell proliferation	16815647
Hgene	PID1	GO:1903077	negative regulation of protein localization to plasma membrane	19079291

Fusion gene breakpoints across PID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DNER (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-44-5643-01A	PID1	chr2	230020534	-	DNER	chr2	230456604	-

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Fusion Gene ORF analysis for PID1-DNER

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000354069	ENST00000482831	PID1	chr2	230020534	-	DNER	chr2	230456604	-
5CDS-intron	ENST00000392054	ENST00000482831	PID1	chr2	230020534	-	DNER	chr2	230456604	-
5CDS-intron	ENST00000392055	ENST00000482831	PID1	chr2	230020534	-	DNER	chr2	230456604	-
5UTR-3CDS	ENST00000482518	ENST00000341772	PID1	chr2	230020534	-	DNER	chr2	230456604	-
5UTR-intron	ENST00000482518	ENST00000482831	PID1	chr2	230020534	-	DNER	chr2	230456604	-
Frame-shift	ENST00000392054	ENST00000341772	PID1	chr2	230020534	-	DNER	chr2	230456604	-
In-frame	ENST00000354069	ENST00000341772	PID1	chr2	230020534	-	DNER	chr2	230456604	-
In-frame	ENST00000392055	ENST00000341772	PID1	chr2	230020534	-	DNER	chr2	230456604	-
intron-3CDS	ENST00000409462	ENST00000341772	PID1	chr2	230020534	-	DNER	chr2	230456604	-
intron-intron	ENST00000409462	ENST00000482831	PID1	chr2	230020534	-	DNER	chr2	230456604	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000392055	PID1	chr2	230020534	-	ENST00000341772	DNER	chr2	230456604	-	3268	419	80	2356	758
ENST00000354069	PID1	chr2	230020534	-	ENST00000341772	DNER	chr2	230456604	-	3156	307	10	2244	744

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392055	ENST00000341772	PID1	chr2	230020534	-	DNER	chr2	230456604	-	0.001835372	0.9981646
ENST00000354069	ENST00000341772	PID1	chr2	230020534	-	DNER	chr2	230456604	-	0.000854412	0.9991456

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Fusion Genomic Features for PID1-DNER

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PID1-DNER

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:230020534/chr2:230456604)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DNER Q8NFT8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

309_348

738.0

Domain

EGF-like 3

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

349_390

738.0

Domain

EGF-like 4

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

392_428

738.0

Domain

EGF-like 5

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

430_466

738.0

Domain

EGF-like 6

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

468_503

738.0

Domain

EGF-like 7

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

505_541

738.0

Domain

EGF-like 8%3B calcium-binding

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

543_579

738.0

Domain

EGF-like 9

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

546_568

738.0

Domain

Note=Follistatin-like

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

581_617

738.0

Domain

EGF-like 10%3B calcium-binding

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

94_133

738.0

Domain

EGF-like 2

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

662_737

738.0

Topological domain

Cytoplasmic

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

641_661

738.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PID1

chr2:230020534

chr2:230456604

ENST00000354069

93_250

251.0

Domain

PID

Hgene

PID1

chr2:230020534

chr2:230456604

ENST00000392054

93_250

249.0

Domain

PID

Hgene

PID1

chr2:230020534

chr2:230456604

ENST00000392055

93_250

218.0

Domain

PID

Hgene

PID1

chr2:230020534

chr2:230456604

ENST00000409462

93_250

169.0

Domain

PID

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

44_92

738.0

Domain

EGF-like 1

Tgene

DNER

chr2:230020534

chr2:230456604

ENST00000341772

35_640

738.0

Topological domain

Extracellular

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Fusion Gene Sequence for PID1-DNER

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>65182_65182_1_PID1-DNER_PID1_chr2_230020534_ENST00000354069_DNER_chr2_230456604_ENST00000341772_length(transcript)=3156nt_BP=307nt
ATGAAAAGCCTTGTACAAGAGGCTTCGTGCCATGTTCAGCCTGCCCCTTAGCCTTCCACTGTGTGAGGACACAGCATTCCTTCCTTCCAA
GTGCTGCAGCTCTCACAAGACAATCAAACAAGCCCGCACCTTGATCATGATCTTCCTAGCCTCCGGAACGCACTTTCAGACCATGCTGAA
GTCTAAATTGAATGTCTTAACACTGAAAAAGGAACCTCTCCCAGCGGTCATCTTCCATGAGCCGGAGGCCATTGAGCTGTGCACGACCAC
ACCGCTGATGAAGACAAGGACTCACAGTGGCTGCAAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCATGGCAACTGCAGCAG
CAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCC
AGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCA
GGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATAT
TGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCA
AGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGACGAAGTGTGACCCC
CCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTGAATGATTCTGTGAC
TAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTC
AGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGGCAACTTTTTCCTGTACCTGTGAGGAGCAGTACGTGGGTACTTTCTGTGAAGAATA
CGATGCTTGCCAGAGGAAACCTTGCCAAAACAACGCGAGCTGTATTGATGCAAATGAAAAGCAAGATGGGAGCAATTTCACCTGTGTTTG
CCTTCCTGGTTATACTGGAGAGCTTTGCCAGTCCAAGATTGATTACTGCATCCTAGACCCATGCAGAAATGGAGCAACATGCATTTCCAG
TCTCAGTGGATTCACCTGCCAGTGTCCAGAAGGATACTTCGGATCTGCTTGTGAAGAAAAGGTGGACCCCTGCGCCTCGTCTCCGTGCCA
GAACAACGGCACCTGCTATGTGGACGGGGTACACTTTACCTGCAACTGCAGCCCGGGCTTCACAGGGCCGACCTGTGCCCAGCTTATTGA
CTTCTGTGCCCTCAGCCCCTGTGCTCATGGCACGTGCCGCAGCGTGGGCACCAGCTACAAATGCCTCTGTGATCCAGGTTACCATGGCCT
CTACTGTGAGGAGGAATATAATGAGTGCCTCTCCGCTCCATGCCTGAATGCAGCCACCTGCAGGGACCTCGTTAATGGCTATGAGTGTGT
GTGCCTGGCAGAATACAAAGGAACACACTGTGAATTGTACAAGGATCCCTGCGCTAACGTCAGCTGTCTGAACGGAGCCACCTGTGACAG
CGACGGCCTGAATGGCACGTGCATCTGTGCACCCGGGTTTACAGGTGAAGAGTGCGACATTGACATAAATGAATGTGACAGTAACCCCTG
CCACCATGGTGGGAGCTGCCTGGACCAGCCCAATGGTTATAACTGCCACTGCCCGCATGGTTGGGTGGGAGCAAACTGTGAGATCCACCT
CCAATGGAAGTCCGGGCACATGGCGGAGAGCCTCACCAACATGCCACGGCACTCCCTCTACATCATCATTGGAGCCCTCTGCGTGGCCTT
CATCCTTATGCTGATCATCCTGATCGTGGGGATTTGCCGCATCAGCCGCATTGAATACCAGGGTTCTTCCAGGCCAGCCTATGAGGAGTT
CTACAACTGCCGCAGCATCGACAGCGAGTTCAGCAATGCCATTGCATCCATCCGGCATGCCAGGTTTGGAAAGAAATCCCGGCCTGCAAT
GTATGATGTGAGCCCCATCGCCTATGAAGATTACAGTCCTGATGACAAACCCTTGGTCACACTGATTAAAACTAAAGATTTGTAATCTTT
TTTTGGATTATTTTTCAAAAAGATGAGATACTACACTCATTTAAATATTTTTAAGAAAATAAAAAGCTTAAGAAATTTAAAATGCTAGCT
GCTCAAGAGTTTTCAGTAGAATATTTAAGAACTAATTTTCTGCAGCTTTTAGTTTGGAAAAAATATTTTAAAAACAAAATTTGTGAAACC
TATAGACGATGTTTTAATGTACCTTCAGCTCTCTAAACTGTGTGCTTCTACTAGTGTGTGCTCTTTTCACTGTAGACACTATCACGAGAC
CCAGATTAATTTCTGTGGTTGTTACAGAATAAGTCTAATCAAGGAGAAGTTTCTGTTTGACGTTTGAGTGCCGGCTTTCTGAGTAGAGTT
AGGAAAACCACGTAACGTAGCATATGATGTATAATAGAGTATACCCGTTACTTAAAAAGAAGTCTGAAATGTTCGTTTTGTGGAAAAGAA
ACTAGTTAAATTTACTATTCCTAACCCGAATGAAATTAGCCTTTGCCTTATTCTGTGCATGGGTAAGTAACTTATTTCTGCACTGTTTTG
TTGAACTTTGTGGAAACATTCTTTCGAGTTTGTTTTTGTCATTTTCGTAACAGTCGTCGAACTAGGCCTCAAAAACATACGTAACGAAAA
GGCCTAGCGAGGCAAATTCTGATTGATTTGAATCTATATTTTTCTTTAAAAAGTCAAGGGTTCTATATTGTGAGTAAATTAAATTTACAT
TTGAGTTGTTTGTTGCTAAGAGGTAGTAAATGTAAGAGAGTACTGGTTCCTTCAGTAGTGAGTATTTCTCATAGTGCAGCTTTATTTATC
TCCAGGATGTTTTTGTGGCTGTATTTGATTGATATGTGCTTCTTCTGATTCTTGCTAATTTCCAACCATATTGAATAAATGTGATCAAGT

>65182_65182_1_PID1-DNER_PID1_chr2_230020534_ENST00000354069_DNER_chr2_230456604_ENST00000341772_length(amino acids)=744AA_BP=99
MYKRLRAMFSLPLSLPLCEDTAFLPSKCCSSHKTIKQARTLIMIFLASGTHFQTMLKSKLNVLTLKKEPLPAVIFHEPEAIELCTTTPLM
KTRTHSGCKLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATV
TLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQA
SGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDAC
QRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNG
TCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLA
EYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWK
SGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDV

--------------------------------------------------------------
>65182_65182_2_PID1-DNER_PID1_chr2_230020534_ENST00000392055_DNER_chr2_230456604_ENST00000341772_length(transcript)=3268nt_BP=419nt
AGTCCTCTCGCAGCTGCGCCAGGACAGCCGGCGCGCGGCCGTGCCCACAAGTTGCCGGCAGCTGAGCGCCGCGCCTCCTCCTGCTCGCAG
CCCCCTACGCCCACCCGGCGGCGGTGGCCAGCGCCAGGACGCACATCCCGCGGACACCGACCCCAGATGTAAAGCGGGACCCCAGCCCCT
CGCCCCCCGGCGCGATCGACAGTCTCGCCAGCGTCTCCTCTGCCAAAACCCAGGGCTGGAAGATGTGGCAGCCGGCCACGGAGCGCCTGC
AGCACTTTCAGACCATGCTGAAGTCTAAATTGAATGTCTTAACACTGAAAAAGGAACCTCTCCCAGCGGTCATCTTCCATGAGCCGGAGG
CCATTGAGCTGTGCACGACCACACCGCTGATGAAGACAAGGACTCACAGTGGCTGCAAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTT
GTCACCATGGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTG
AACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTG
ACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATC
AAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGA
ACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCA
TAGATGGACGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTG
GTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTC
ACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGGCAACTTTTTCCTGTACCTGTGAGGAGCAGTACG
TGGGTACTTTCTGTGAAGAATACGATGCTTGCCAGAGGAAACCTTGCCAAAACAACGCGAGCTGTATTGATGCAAATGAAAAGCAAGATG
GGAGCAATTTCACCTGTGTTTGCCTTCCTGGTTATACTGGAGAGCTTTGCCAGTCCAAGATTGATTACTGCATCCTAGACCCATGCAGAA
ATGGAGCAACATGCATTTCCAGTCTCAGTGGATTCACCTGCCAGTGTCCAGAAGGATACTTCGGATCTGCTTGTGAAGAAAAGGTGGACC
CCTGCGCCTCGTCTCCGTGCCAGAACAACGGCACCTGCTATGTGGACGGGGTACACTTTACCTGCAACTGCAGCCCGGGCTTCACAGGGC
CGACCTGTGCCCAGCTTATTGACTTCTGTGCCCTCAGCCCCTGTGCTCATGGCACGTGCCGCAGCGTGGGCACCAGCTACAAATGCCTCT
GTGATCCAGGTTACCATGGCCTCTACTGTGAGGAGGAATATAATGAGTGCCTCTCCGCTCCATGCCTGAATGCAGCCACCTGCAGGGACC
TCGTTAATGGCTATGAGTGTGTGTGCCTGGCAGAATACAAAGGAACACACTGTGAATTGTACAAGGATCCCTGCGCTAACGTCAGCTGTC
TGAACGGAGCCACCTGTGACAGCGACGGCCTGAATGGCACGTGCATCTGTGCACCCGGGTTTACAGGTGAAGAGTGCGACATTGACATAA
ATGAATGTGACAGTAACCCCTGCCACCATGGTGGGAGCTGCCTGGACCAGCCCAATGGTTATAACTGCCACTGCCCGCATGGTTGGGTGG
GAGCAAACTGTGAGATCCACCTCCAATGGAAGTCCGGGCACATGGCGGAGAGCCTCACCAACATGCCACGGCACTCCCTCTACATCATCA
TTGGAGCCCTCTGCGTGGCCTTCATCCTTATGCTGATCATCCTGATCGTGGGGATTTGCCGCATCAGCCGCATTGAATACCAGGGTTCTT
CCAGGCCAGCCTATGAGGAGTTCTACAACTGCCGCAGCATCGACAGCGAGTTCAGCAATGCCATTGCATCCATCCGGCATGCCAGGTTTG
GAAAGAAATCCCGGCCTGCAATGTATGATGTGAGCCCCATCGCCTATGAAGATTACAGTCCTGATGACAAACCCTTGGTCACACTGATTA
AAACTAAAGATTTGTAATCTTTTTTTGGATTATTTTTCAAAAAGATGAGATACTACACTCATTTAAATATTTTTAAGAAAATAAAAAGCT
TAAGAAATTTAAAATGCTAGCTGCTCAAGAGTTTTCAGTAGAATATTTAAGAACTAATTTTCTGCAGCTTTTAGTTTGGAAAAAATATTT
TAAAAACAAAATTTGTGAAACCTATAGACGATGTTTTAATGTACCTTCAGCTCTCTAAACTGTGTGCTTCTACTAGTGTGTGCTCTTTTC
ACTGTAGACACTATCACGAGACCCAGATTAATTTCTGTGGTTGTTACAGAATAAGTCTAATCAAGGAGAAGTTTCTGTTTGACGTTTGAG
TGCCGGCTTTCTGAGTAGAGTTAGGAAAACCACGTAACGTAGCATATGATGTATAATAGAGTATACCCGTTACTTAAAAAGAAGTCTGAA
ATGTTCGTTTTGTGGAAAAGAAACTAGTTAAATTTACTATTCCTAACCCGAATGAAATTAGCCTTTGCCTTATTCTGTGCATGGGTAAGT
AACTTATTTCTGCACTGTTTTGTTGAACTTTGTGGAAACATTCTTTCGAGTTTGTTTTTGTCATTTTCGTAACAGTCGTCGAACTAGGCC
TCAAAAACATACGTAACGAAAAGGCCTAGCGAGGCAAATTCTGATTGATTTGAATCTATATTTTTCTTTAAAAAGTCAAGGGTTCTATAT
TGTGAGTAAATTAAATTTACATTTGAGTTGTTTGTTGCTAAGAGGTAGTAAATGTAAGAGAGTACTGGTTCCTTCAGTAGTGAGTATTTC
TCATAGTGCAGCTTTATTTATCTCCAGGATGTTTTTGTGGCTGTATTTGATTGATATGTGCTTCTTCTGATTCTTGCTAATTTCCAACCA

>65182_65182_2_PID1-DNER_PID1_chr2_230020534_ENST00000392055_DNER_chr2_230456604_ENST00000341772_length(amino acids)=758AA_BP=113
MLAAPYAHPAAVASARTHIPRTPTPDVKRDPSPSPPGAIDSLASVSSAKTQGWKMWQPATERLQHFQTMLKSKLNVLTLKKEPLPAVIFH
EPEAIELCTTTPLMKTRTHSGCKLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPAT
QEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQ
CSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCE
EQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEE
KVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAAT
CRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPH
GWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRH

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Fusion Gene PPI Analysis for PID1-DNER

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	DNER	chr2:230020534	chr2:230456604	ENST00000341772		0	13	677_680	92.0	738.0	AP1G1 and somatodendritic targeting

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	DNER	chr2:230020534	chr2:230456604	ENST00000341772		0	13	44_133	92.0	738.0	NOTCH1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PID1-DNER

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PID1-DNER

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source