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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARIH2-DLG2 (FusionGDB2 ID:6531)

Fusion Gene Summary for ARIH2-DLG2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARIH2-DLG2
Fusion gene ID: 6531
HgeneTgene
Gene symbol

ARIH2

DLG2

Gene ID

10425

4355

Gene nameariadne RBR E3 ubiquitin protein ligase 2membrane palmitoylated protein 2
SynonymsARI2|TRIAD1DLG2
Cytomap

3p21.31

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ARIH2RING-type E3 ubiquitin transferase ARIH2all-trans retinoic acid inducible RING fingerariadne homolog 2protein ariadne-2 homologMAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Modification date2020031320200313
UniProtAcc

O95376

Q15700

Ensembl transtripts involved in fusion geneENST00000356401, ENST00000449376, 
ENST00000490095, 		ENST00000280241, 
ENST00000330014, ENST00000376104, 
ENST00000376106, ENST00000398301, 
ENST00000398304, ENST00000398309, 
ENST00000404783, ENST00000418306, 
ENST00000426717, ENST00000472545, 
ENST00000524982, ENST00000530800, 
ENST00000531015, ENST00000532653, 
ENST00000537455, ENST00000543673, 
Fusion gene scores* DoF score10 X 9 X 7=63045 X 44 X 9=17820
# samples 1248
** MAII scorelog2(12/630*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/17820*10)=-5.21431912080077
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARIH2 [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARIH2(48975635)-DLG2(83753495), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARIH2

GO:0000209

protein polyubiquitination

16118314|19340006

HgeneARIH2

GO:0006511

ubiquitin-dependent protein catabolic process

16118314

HgeneARIH2

GO:0016567

protein ubiquitination

24076655

HgeneARIH2

GO:0048588

developmental cell growth

19340006

HgeneARIH2

GO:0070534

protein K63-linked ubiquitination

19340006

HgeneARIH2

GO:0070936

protein K48-linked ubiquitination

16118314|19340006

HgeneARIH2

GO:0071425

hematopoietic stem cell proliferation

16118314|19340006


check buttonFusion gene breakpoints across ARIH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DLG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AFN068512ARIH2chr3

48975635

+DLG2chr11

83753495

-


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Fusion Gene ORF analysis for ARIH2-DLG2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356401ENST00000280241ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000330014ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000376104ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000376106ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000398301ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000398304ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000398309ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000404783ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000418306ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000426717ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000472545ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000524982ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000530800ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000531015ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000532653ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000537455ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000356401ENST00000543673ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000280241ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000330014ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000376104ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000376106ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000398301ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000398304ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000398309ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000404783ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000418306ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000426717ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000472545ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000524982ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000530800ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000531015ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000532653ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000537455ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000449376ENST00000543673ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000280241ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000330014ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000376104ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000376106ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000398301ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000398304ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000398309ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000404783ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000418306ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000426717ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000472545ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000524982ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000530800ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000531015ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000532653ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000537455ARIH2chr3

48975635

+DLG2chr11

83753495

-
intron-intronENST00000490095ENST00000543673ARIH2chr3

48975635

+DLG2chr11

83753495

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARIH2-DLG2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARIH2-DLG2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48975635/:83753495)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARIH2

O95376

DLG2

Q15700

FUNCTION: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000250|UniProtKB:Q9Y4X5, ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655}.FUNCTION: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARIH2-DLG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARIH2-DLG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARIH2-DLG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARIH2-DLG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource