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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PIH1D1-KPNB1 (FusionGDB2 ID:65333) |
Fusion Gene Summary for PIH1D1-KPNB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIH1D1-KPNB1 | Fusion gene ID: 65333 | Hgene | Tgene | Gene symbol | PIH1D1 | KPNB1 | Gene ID | 55011 | 3837 |
| Gene name | PIH1 domain containing 1 | karyopherin subunit beta 1 | |
| Synonyms | MOT48|NOP17|Pih1 | IMB1|IPO1|IPOB|Impnb|NTF97 | |
| Cytomap | 19q13.33 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PIH1 domain-containing protein 1nucleolar protein 17 homolog | importin subunit beta-1PTAC97importin 1importin 90importin beta-1 subunitkaryopherin (importin) beta 1nuclear factor p97pore targeting complex 97 kDa subunit | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q14974 | |
| Ensembl transtripts involved in fusion gene | ENST00000262265, ENST00000596049, ENST00000602226, | ENST00000577918, ENST00000290158, ENST00000535458, ENST00000537679, ENST00000540627, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 14 X 17 X 8=1904 |
| # samples | 3 | 17 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(17/1904*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PIH1D1 [Title/Abstract] AND KPNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PIH1D1(49954741)-KPNB1(45757385), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PIH1D1-KPNB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIH1D1 | GO:0031334 | positive regulation of protein complex assembly | 24036451 |
| Tgene | KPNB1 | GO:0006606 | protein import into nucleus | 7615630|15964792 |
| Tgene | KPNB1 | GO:0006610 | ribosomal protein import into nucleus | 9687515 |
| Fusion gene breakpoints across PIH1D1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KPNB1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-Z6-A9VB | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
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Fusion Gene ORF analysis for PIH1D1-KPNB1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000262265 | ENST00000577918 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| 5CDS-intron | ENST00000596049 | ENST00000577918 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| Frame-shift | ENST00000262265 | ENST00000290158 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| Frame-shift | ENST00000262265 | ENST00000535458 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| Frame-shift | ENST00000262265 | ENST00000537679 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| Frame-shift | ENST00000262265 | ENST00000540627 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| In-frame | ENST00000596049 | ENST00000290158 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| In-frame | ENST00000596049 | ENST00000535458 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| In-frame | ENST00000596049 | ENST00000537679 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| In-frame | ENST00000596049 | ENST00000540627 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| intron-3CDS | ENST00000602226 | ENST00000290158 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| intron-3CDS | ENST00000602226 | ENST00000535458 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| intron-3CDS | ENST00000602226 | ENST00000537679 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| intron-3CDS | ENST00000602226 | ENST00000540627 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| intron-intron | ENST00000602226 | ENST00000577918 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000596049 | PIH1D1 | chr19 | 49954741 | - | ENST00000535458 | KPNB1 | chr17 | 45757385 | + | 703 | 196 | 658 | 269 | 129 |
| ENST00000596049 | PIH1D1 | chr19 | 49954741 | - | ENST00000290158 | KPNB1 | chr17 | 45757385 | + | 3575 | 196 | 658 | 269 | 129 |
| ENST00000596049 | PIH1D1 | chr19 | 49954741 | - | ENST00000540627 | KPNB1 | chr17 | 45757385 | + | 750 | 196 | 658 | 269 | 129 |
| ENST00000596049 | PIH1D1 | chr19 | 49954741 | - | ENST00000537679 | KPNB1 | chr17 | 45757385 | + | 750 | 196 | 658 | 269 | 129 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000596049 | ENST00000535458 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + | 0.041004766 | 0.9589953 |
| ENST00000596049 | ENST00000290158 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + | 0.05638837 | 0.9436116 |
| ENST00000596049 | ENST00000540627 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + | 0.045689728 | 0.9543103 |
| ENST00000596049 | ENST00000537679 | PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + | 0.045689728 | 0.9543103 |
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Fusion Genomic Features for PIH1D1-KPNB1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + | 0.60430455 | 0.3956954 |
| PIH1D1 | chr19 | 49954741 | - | KPNB1 | chr17 | 45757385 | + | 0.60430455 | 0.3956954 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PIH1D1-KPNB1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49954741/chr17:45757385) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | KPNB1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. {ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:9687515}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 786_829 | 784 | 877.0 | Repeat | HEAT 18 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 831_873 | 784 | 877.0 | Repeat | HEAT 19 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 337_341 | 784 | 877.0 | Compositional bias | Note=Poly-Asp | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 21_101 | 784 | 877.0 | Domain | Importin N-terminal | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 329_342 | 784 | 877.0 | Region | Note=IAB-binding | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 334_419 | 784 | 877.0 | Region | Note=Ran-GTP binding | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 129_160 | 784 | 877.0 | Repeat | HEAT 4 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 170_202 | 784 | 877.0 | Repeat | HEAT 5 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 212_247 | 784 | 877.0 | Repeat | HEAT 6 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 253_302 | 784 | 877.0 | Repeat | HEAT 7 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 2_31 | 784 | 877.0 | Repeat | HEAT 1 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 314_360 | 784 | 877.0 | Repeat | HEAT 8 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 33_65 | 784 | 877.0 | Repeat | HEAT 2 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 364_394 | 784 | 877.0 | Repeat | HEAT 9 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 402_438 | 784 | 877.0 | Repeat | HEAT 10 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 449_485 | 784 | 877.0 | Repeat | HEAT 11 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 500_537 | 784 | 877.0 | Repeat | HEAT 12 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 544_592 | 784 | 877.0 | Repeat | HEAT 13 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 600_639 | 784 | 877.0 | Repeat | HEAT 14 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 644_681 | 784 | 877.0 | Repeat | HEAT 15 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 686_724 | 784 | 877.0 | Repeat | HEAT 16 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 732_776 | 784 | 877.0 | Repeat | HEAT 17 | |
| Tgene | KPNB1 | chr19:49954741 | chr17:45757385 | ENST00000290158 | 18 | 22 | 85_123 | 784 | 877.0 | Repeat | HEAT 3 |
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Fusion Gene Sequence for PIH1D1-KPNB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >65333_65333_1_PIH1D1-KPNB1_PIH1D1_chr19_49954741_ENST00000596049_KPNB1_chr17_45757385_ENST00000290158_length(transcript)=3575nt_BP=196nt GGACTCCCCGCGAAAAACCGGGCGCCCAGGCCTGGGGAACGCAGCGAGCAGCGCCGGCCGGGCAGACTCTCACCAGTGCGCATGCGTGGC TCTCCGGCACCGGGCCATGGCGAACCCGAAGCTGCTGGGAATGGGGCTAAGCGAGGCGGAGGCGATCGGTGCTGATTCGGCGCGATTTGA GGAGCTGCTGCTGCAGCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGAT CACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCT AGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTG AGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTG GAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCC ACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGG AAAAGAGAAAAACAATGGAGTTACTTATTTAAAAAAAAAGAAAGAAAGTTATCTCTTCCCAGGAGAGGCTAGAAGTAGCTTTTCTGTCTT TTGGCCAGTGCCGAGTGGAATGCCTGGTTTGGGGGAGGAGGAGGGACTGGGTTCAGCTGTGGTGCTTTGTTGTAAAAGGCAGCCTGGCCT TTGCTACTGAGGAGAAAGATGGAGCCTGGGTCTCAAGCCCACCTTCGCTGTACCTTTGCCACATGGTACTGTATGCTTGCCAGCTAGAAG GAGGGTCAGGGATTTTTTACAGTCTGAGAATGAGTGTGTGTGAGTGAGGCGGTATCCACATTTTCAACTTCAAGTCATTGCAGTTTCTTT TTCCCAGAAAACAAGGGGTTAGATGTTGCATTTCATAAAACTAACCGAAGTTTTGTTTACTGATGCAGCACAAGAGATGTAAAAAAAAAA AAAAAAAAAAAAAAAAAAACACACACACAGAGGAAAGACGCTCTTTAGGTTTTGTTTTGTTTTTTTTTTTTGGTTTTGTTTTTTGTTTTT TTTACTCTAGGGAAAACACTGACGAATGGTCAGAGCTCCTATCCTGATCTTTTCATCAAGGCGCCTTTCCTAATAATATGGTTCAACTGT GAATGTAGAAGTGGGGGGGAGGGGGGAGAAAAAGAAAACTCTGGCGTTAGAGGATATAGAAAAATATAAGTACAATTGTTACAAATAACG CAGACTTCAAAAACAAAAAAATCACAACCCAAACAAACCAAAATTTAAATGATCAGAATTGGCAGCACAAAGAAAACGCCCTCTCCTGAC TTGTATTGTGGCAGTCTGAACGCCCCCAGAAAATTGTGCCAAAGAGTTTAGAAAAATAAATATACAATAAAAGTAAACACATACACACAA AACAGCAAACTTCAGGTAACTATTTTGGATTGCAAACAGGATAAATTAAATGTTCAAACAATCTGATAAAATAACCATTTGGAAACTGCT TGGCCTTCTGTTCTTTTATTTGATTGACTACAATGCGGTATTGGTCTCTTGCTGCACTTCAAAAGCAACCAACAAAACAAAAACAAAAAA AAGTGTGTGTTGTGTGAATACACACACACACTAACTAGAAGTCTTGTGATGAAAATGGCACTTGGAAAAGGTTTTATTTTTCCACTGAAG TTGAAGGTTAATAAAATGGTGTCAAACGTCCCCTGGTCACACACTTGAATATTTTTTTAGAAGTGTGATGTGGTATGATTACCATAAATC AGACTTAATTATTTTCCCTTTTACAAGGGAACAGGGCATCCTGAATTTTAGAGCCTTTCAGCAATAAGAAGGGATGTTGGTGAGCTTTGA TCCTCTTTTGGTTTTGCAGTTGTTAGGAGTTTTTGCTGGCATTTTGAATATGCTGCTTTCAGAAAAACCAAGGAAGTTTTAAAATTGCTT CCTGGTCCTTAGAGGACTAAAAACAAGACCCTCATTCCCACTTTCATTTCCACTCTAGCAAAAACTGGGCTTGCGTTTTTCTCCAACTCC TCGTTTATATCCTCCCTTCCATGTCCAAGCCTTCCATTCCTAAGTGGGATTGGCTCAGTTTTGCCCATCCATATGGCAGCATCTCTAATA GCTCTTGTACAGGGTATCAGATATTGTGCCTTTTGGTGCCAGGTTCAAAGTCAAGTGCCGATCTATGAACCAGTGTACAAAAAAAAAAAA ATCCAGGTATTTGAAGGAGAGACGCTCCATTGTGAATAAAGAGCTCATACCAGCTCCTAAGCCCTATTAAGAAGAGGCCTGGTCCTCTAA TGCCTTGTTTCCATTTCAGTTGTTCTTTGAGAGACAGAATGATGTACTAACCATTCGTGATTATTAAGATAGGGTTGGGTCAGGGCTTAG GGAGGGGGCAGAAATATTGGGGATAGAAAAAAAATCTGATCATTCCTCAGTGCTACCCATTTCTGTCCTGTGTGGGCTGCTTAGCTAGAC AGCAGGAGAATAAAGTACACCGAGAACCATAATGAAAAAACCTTCCGTGTGTTTTGTCATGTTTTGTTCCAGGGAAGCAGTTGATGAGTG CTGTTACTAATGCTTTCTCCCAGATCCATTCAGTGGTGGAGAGGAGGAAAATGGGCTGGTTGGATGTGGTCTTGGTGCCTTGCAGTTACT CTGCACTGGTTATGCATTTAATTCTCCTCTTTTCTAGTTAACCTTTTGCCAGTGGGTTTTCCATAGTCTGGGTATTTGTCCTTATATCAG TTATACCACCTAAGGCAACTGGGTGCAAAATGCATTCTGTTCACTCACTGTCTGGGCCTTCCCCACCCTAGTCTTGGCACATTCCTTCAA GAATGTAGTTACCGTCTGCTTGGGAAGATGTCAGTGCAAATGTGAAGATAATGGGCATCGGACTAGGCTTTGGTTTGCCACAAGTGGCAG CTGCCTGTATCAATTACATTTATTAATTTTGCTTTTCATTTTTCCCAGTTCTCCTCACCCCCCCTTTGTTGAAATGTTGGACTTGCTGTC AGAGGCAACTGTAATATTGCCTTAGGGACTTGTGGAGAAGGGGAATTGCTCAGTGTAGTGTTTTAACTTTCAGAACCAAGCAATCTATTT ACTCTTACAAATATTTAAGAAGTGTGTTAGTCCAACTTTAAGAAAAATCCAAACTCATCAGCTTTTGATAGCATCTTGGTTTTTGAAACA ACTTCAATCTGTAATTGGCATTCAGAATGCCCTTGGCATGCCAGTCTGTGATGGCATTTAAGACCTGTAAAACACTTGAGCCCAACTCGA >65333_65333_1_PIH1D1-KPNB1_PIH1D1_chr19_49954741_ENST00000596049_KPNB1_chr17_45757385_ENST00000290158_length(amino acids)=129AA_BP= MLLAAAAAAVAGFSMWCVFKPHSLILSFPNIQHPCTLLTSRFFKRWEISSGGPQVIIPMVTDQAWFFSFLSSFVAHVARVFALLVFDLRP -------------------------------------------------------------- >65333_65333_2_PIH1D1-KPNB1_PIH1D1_chr19_49954741_ENST00000596049_KPNB1_chr17_45757385_ENST00000535458_length(transcript)=703nt_BP=196nt GGACTCCCCGCGAAAAACCGGGCGCCCAGGCCTGGGGAACGCAGCGAGCAGCGCCGGCCGGGCAGACTCTCACCAGTGCGCATGCGTGGC TCTCCGGCACCGGGCCATGGCGAACCCGAAGCTGCTGGGAATGGGGCTAAGCGAGGCGGAGGCGATCGGTGCTGATTCGGCGCGATTTGA GGAGCTGCTGCTGCAGCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGAT CACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCT AGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTG AGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTG GAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCC >65333_65333_2_PIH1D1-KPNB1_PIH1D1_chr19_49954741_ENST00000596049_KPNB1_chr17_45757385_ENST00000535458_length(amino acids)=129AA_BP= MLLAAAAAAVAGFSMWCVFKPHSLILSFPNIQHPCTLLTSRFFKRWEISSGGPQVIIPMVTDQAWFFSFLSSFVAHVARVFALLVFDLRP -------------------------------------------------------------- >65333_65333_3_PIH1D1-KPNB1_PIH1D1_chr19_49954741_ENST00000596049_KPNB1_chr17_45757385_ENST00000537679_length(transcript)=750nt_BP=196nt GGACTCCCCGCGAAAAACCGGGCGCCCAGGCCTGGGGAACGCAGCGAGCAGCGCCGGCCGGGCAGACTCTCACCAGTGCGCATGCGTGGC TCTCCGGCACCGGGCCATGGCGAACCCGAAGCTGCTGGGAATGGGGCTAAGCGAGGCGGAGGCGATCGGTGCTGATTCGGCGCGATTTGA GGAGCTGCTGCTGCAGCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGAT CACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCT AGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTG AGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTG GAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCC ACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGG >65333_65333_3_PIH1D1-KPNB1_PIH1D1_chr19_49954741_ENST00000596049_KPNB1_chr17_45757385_ENST00000537679_length(amino acids)=129AA_BP= MLLAAAAAAVAGFSMWCVFKPHSLILSFPNIQHPCTLLTSRFFKRWEISSGGPQVIIPMVTDQAWFFSFLSSFVAHVARVFALLVFDLRP -------------------------------------------------------------- >65333_65333_4_PIH1D1-KPNB1_PIH1D1_chr19_49954741_ENST00000596049_KPNB1_chr17_45757385_ENST00000540627_length(transcript)=750nt_BP=196nt GGACTCCCCGCGAAAAACCGGGCGCCCAGGCCTGGGGAACGCAGCGAGCAGCGCCGGCCGGGCAGACTCTCACCAGTGCGCATGCGTGGC TCTCCGGCACCGGGCCATGGCGAACCCGAAGCTGCTGGGAATGGGGCTAAGCGAGGCGGAGGCGATCGGTGCTGATTCGGCGCGATTTGA GGAGCTGCTGCTGCAGCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGAT CACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCT AGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTG AGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTG GAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCC ACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGG >65333_65333_4_PIH1D1-KPNB1_PIH1D1_chr19_49954741_ENST00000596049_KPNB1_chr17_45757385_ENST00000540627_length(amino acids)=129AA_BP= MLLAAAAAAVAGFSMWCVFKPHSLILSFPNIQHPCTLLTSRFFKRWEISSGGPQVIIPMVTDQAWFFSFLSSFVAHVARVFALLVFDLRP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PIH1D1-KPNB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PIH1D1-KPNB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PIH1D1-KPNB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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